Motif ID: NKX2-2,8.p2

Z-value: 2.217


Transcription factors associated with NKX2-2,8.p2:

Gene SymbolEntrez IDGene Name
NKX2-2 4821 NK2 homeobox 2
NKX2-8 26257 NK2 homeobox 8

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-2chr20_-_21442663-0.332.1e-01Click!
NKX2-8chr14_-_361215360.048.9e-01Click!


Activity profile for motif NKX2-2,8.p2.

activity profile for motif NKX2-2,8.p2


Sorted Z-values histogram for motif NKX2-2,8.p2

Sorted Z-values for motif NKX2-2,8.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-2,8.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_88573949 3.438 NM_001001323
NM_001682
ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

chr10_-_98326435 3.060 TM9SF3
transmembrane 9 superfamily member 3
chr2_+_228064531 2.910 AGFG1
ArfGAP with FG repeats 1
chr4_+_95595419 2.767 PDLIM5
PDZ and LIM domain 5
chr7_+_111879348 2.723 NM_001197079
IFRD1
interferon-related developmental regulator 1
chr2_-_225078931 2.663 CUL3
cullin 3
chr17_-_26648375 2.559 NM_002544
OMG
oligodendrocyte myelin glycoprotein
chr3_-_153541468 2.346 NM_001123228
TMEM14E
transmembrane protein 14E
chr1_+_213245507 2.224 NM_001017424
KCNK2
potassium channel, subfamily K, member 2
chr13_-_40454188 2.201 ELF1
E74-like factor 1 (ets domain transcription factor)
chr9_+_122923864 2.002 CEP110
centrosomal protein 110kDa
chr12_+_63090008 1.954 XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chr8_+_32698892 1.922 NM_001159996
NRG1
neuregulin 1
chr18_-_65766068 1.876 CD226
CD226 molecule
chr12_-_44877769 1.838 SLC38A1
solute carrier family 38, member 1
chr3_+_190990142 1.807 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr1_+_169747788 1.780 PRRC2C
proline-rich coiled-coil 2C
chr1_+_84402962 1.767 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr11_+_12917369 1.736 TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr3_+_160473784 1.689 SCHIP1
schwannomin interacting protein 1
chr16_+_24475129 1.635 RBBP6
retinoblastoma binding protein 6
chr2_-_40593074 1.626 NM_001112802
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr4_-_153523113 1.594 NM_001013415
FBXW7
F-box and WD repeat domain containing 7
chr9_-_21472311 1.584 NM_176891
IFNE
interferon, epsilon
chr4_+_69996780 1.571 NM_001074
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr6_-_88095714 1.547 NM_198568
GJB7
gap junction protein, beta 7, 25kDa
chr3_+_160473729 1.544 NM_001197107
NM_001197108
NM_014575
SCHIP1


schwannomin interacting protein 1


chr1_+_144198658 1.533 LIX1L
Lix1 homolog (mouse)-like
chr10_+_102285562 1.526 NM_017902
HIF1AN
hypoxia inducible factor 1, alpha subunit inhibitor
chr7_+_141265085 1.500 NM_001001656
OR9A4
olfactory receptor, family 9, subfamily A, member 4
chr20_-_1298493 1.499 FKBP1A
FK506 binding protein 1A, 12kDa
chr1_-_214963279 1.497 NM_001438
ESRRG
estrogen-related receptor gamma
chr9_+_95273241 1.472 FAM120A
family with sequence similarity 120A
chr12_-_10846435 1.464 NM_023919
TAS2R7
taste receptor, type 2, member 7
chr11_-_26700121 1.454 NM_178498
SLC5A12
solute carrier family 5 (sodium/glucose cotransporter), member 12
chr5_+_159781413 1.443 NM_004219
PTTG1
pituitary tumor-transforming 1
chr5_+_159781454 1.431 PTTG1
pituitary tumor-transforming 1
chr15_-_53996597 1.418 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr8_+_118216517 1.399 NM_001172814
NM_173851
SLC30A8

solute carrier family 30 (zinc transporter), member 8

chr7_+_69869099 1.376 AUTS2
autism susceptibility candidate 2
chr4_-_170314382 1.367 SH3RF1
SH3 domain containing ring finger 1
chr11_+_58967192 1.361 NM_001004728
OR5A1
olfactory receptor, family 5, subfamily A, member 1
chr16_+_55373241 1.338 NUP93
nucleoporin 93kDa
chr12_-_10870134 1.338 NM_023921
TAS2R10
taste receptor, type 2, member 10
chr17_+_50333021 1.334 NM_005486
TOM1L1
target of myb1 (chicken)-like 1
chr1_-_161379606 1.327 RGS5
regulator of G-protein signaling 5
chr5_+_54491702 1.326 NM_001008397
GPX8
glutathione peroxidase 8 (putative)
chr5_-_160044844 1.320 ATP10B
ATPase, class V, type 10B
chr17_+_3324096 1.279 NM_001128085
ASPA
aspartoacylase
chr7_+_113853790 1.278 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr3_-_121065112 1.261


chr19_+_11837843 1.258 NM_152262
ZNF439
zinc finger protein 439
chr17_+_55098280 1.254 CLTC
clathrin, heavy chain (Hc)
chr14_+_66901237 1.248 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr2_-_37727472 1.244 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr7_+_115650240 1.227 NM_152829
TES
testis derived transcript (3 LIM domains)
chr14_-_94677807 1.216 NM_030621
DICER1
dicer 1, ribonuclease type III
chr12_+_32578513 1.212 FGD4
FYVE, RhoGEF and PH domain containing 4
chr15_+_22778233 1.211 SNRPN
small nuclear ribonucleoprotein polypeptide N
chr3_-_33675484 1.196 CLASP2
cytoplasmic linker associated protein 2
chr10_+_90336489 1.193 NM_001010939
LIPJ
lipase, family member J
chr3_+_153499883 1.178 NM_207293
NM_207294
NM_207295
NM_207296
NM_207297
MBNL1




muscleblind-like (Drosophila)




chr11_-_57728228 1.173 NM_001004459
OR1S2
olfactory receptor, family 1, subfamily S, member 2
chr3_-_115380539 1.163 NM_000796
NM_033663
DRD3

dopamine receptor D3

chr6_-_138862271 1.145 NM_001144060
NHSL1
NHS-like 1
chr5_+_147754467 1.123 FBXO38
F-box protein 38
chr2_-_162717159 1.114 NM_002054
GCG
glucagon
chr11_+_22646229 1.104 NM_177553
GAS2
growth arrest-specific 2
chr12_+_84792203 1.100 NM_006183
NTS
neurotensin
chr12_+_54106304 1.098 NM_001005183
OR6C76
olfactory receptor, family 6, subfamily C, member 76
chr1_-_21288259 1.095 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr6_+_55147029 1.091 NM_001526
HCRTR2
hypocretin (orexin) receptor 2
chr6_+_142552320 1.070 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr14_-_44046202 1.069 NM_032135
FSCB
fibrous sheath CABYR binding protein
chr21_+_34112456 1.051 ITSN1
intersectin 1 (SH3 domain protein)
chr3_-_152449591 1.049 NM_001081455
P2RY14
purinergic receptor P2Y, G-protein coupled, 14
chr12_-_85756766 1.048 NM_013244
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr18_-_62422195 1.043 NM_021153
CDH19
cadherin 19, type 2
chr11_+_93916653 1.028 NM_002033
PIWIL4
FUT4
piwi-like 4 (Drosophila)
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chr20_+_56659693 1.028 NM_001001433
NM_001134772
NM_001134773
NM_003763
STX16



syntaxin 16



chr21_-_30786145 1.026 NM_181609
KRTAP19-3
keratin associated protein 19-3
chr4_+_91375204 1.022 NM_207491
FAM190A
family with sequence similarity 190, member A
chr12_-_44919818 1.017 SLC38A1
solute carrier family 38, member 1
chr2_+_170742900 1.015 NM_001083615
NM_001171642
NM_138995
MYO3B


myosin IIIB


chr5_-_58331515 1.013 NM_001197223
PDE4D
phosphodiesterase 4D, cAMP-specific
chr14_+_95915774 1.006 NM_016472
C14orf129
chromosome 14 open reading frame 129
chr4_+_114433551 1.000 ANK2
ankyrin 2, neuronal
chr2_-_225086564 0.997 CUL3
cullin 3
chr3_+_37415971 0.996 NM_178339
NM_178342
C3orf35

chromosome 3 open reading frame 35

chr1_-_156816312 0.989 NM_001004477
OR10X1
olfactory receptor, family 10, subfamily X, member 1
chr2_+_183290912 0.981 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr1_-_108536885 0.973 NM_213651
SLC25A24
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
chr5_-_37220702 0.963 C5orf42
chromosome 5 open reading frame 42
chr20_+_56919233 0.948 GNAS
GNAS complex locus
chr5_-_58607673 0.933 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr17_-_1195096 0.929 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr1_-_242073094 0.929 NM_005465
NM_181690
AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

chr3_+_101911083 0.928 TFG
TRK-fused gene
chr18_+_54039730 0.922 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr5_-_63293715 0.922 HTR1A
5-hydroxytryptamine (serotonin) receptor 1A
chr7_+_93373755 0.921 NM_021955
GNGT1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr4_+_75393053 0.915 NM_001013442
EPGN
epithelial mitogen homolog (mouse)
chr1_-_21310462 0.897 NM_003760
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr2_-_61566477 0.897 XPO1
exportin 1 (CRM1 homolog, yeast)
chr12_+_76749199 0.896 NM_014903
NAV3
neuron navigator 3
chr1_-_103269356 0.894 COL11A1
collagen, type XI, alpha 1
chr11_-_62753574 0.890 NM_199352
SLC22A25
solute carrier family 22, member 25
chr6_+_88021644 0.888 ZNF292
zinc finger protein 292
chr15_-_23204887 0.886 NM_000462
UBE3A
ubiquitin protein ligase E3A
chr6_+_45404031 0.877 NM_001015051
NM_001024630
RUNX2

runt-related transcription factor 2

chr11_+_65023038 0.876 MALAT1
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr17_-_2943039 0.866 NM_002548
OR1D2
olfactory receptor, family 1, subfamily D, member 2
chr7_-_92686773 0.864 NM_198151
HEPACAM2
HEPACAM family member 2
chr10_+_129237602 0.854 NM_001030013
NPS
neuropeptide S
chr21_-_26175068 0.851 APP
amyloid beta (A4) precursor protein
chr4_+_53975597 0.842 FIP1L1
FIP1 like 1 (S. cerevisiae)
chr13_-_40454360 0.842 NM_001145353
ELF1
E74-like factor 1 (ets domain transcription factor)
chr3_-_113701073 0.841 NM_001085357
NM_181780
BTLA

B and T lymphocyte associated

chr5_-_58688428 0.834 NM_001197219
PDE4D
phosphodiesterase 4D, cAMP-specific
chr12_-_73889777 0.831 NM_139136
NM_139137
NM_153748
KCNC2


potassium voltage-gated channel, Shaw-related subfamily, member 2


chr1_-_74971679 0.822 NM_001130042
NM_001130043
NM_001134759
NM_001889
CRYZ



crystallin, zeta (quinone reductase)



chr11_+_35154775 0.805 CD44
CD44 molecule (Indian blood group)
chr15_-_75135496 0.801 TSPAN3
tetraspanin 3
chr6_+_154373323 0.792 NM_001145279
NM_001145280
NM_001145281
OPRM1


opioid receptor, mu 1


chr1_+_67168470 0.785 NM_001077701
NM_001077704
MIER1

mesoderm induction early response 1 homolog (Xenopus laevis)

chr3_+_129124591 0.785 NM_207335
KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr14_-_60022487 0.782 NM_174978
C14orf39
chromosome 14 open reading frame 39
chr10_-_37931864 0.777 NM_001190489
MTRNR2L7
MT-RNR2-like 7
chr10_+_63478974 0.774 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr3_-_57301749 0.773 NM_001142733
ASB14
ankyrin repeat and SOCS box containing 14
chr13_-_60887655 0.769 NM_022843
PCDH20
protocadherin 20
chr18_+_54039779 0.767 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr11_+_57714481 0.767 NM_001005283
OR9Q2
olfactory receptor, family 9, subfamily Q, member 2
chr2_-_210888010 0.765 NM_079420
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr5_-_39306465 0.764 FYB
FYN binding protein
chr14_-_20969706 0.763 NM_001170629
CHD8
chromodomain helicase DNA binding protein 8
chr18_+_54039818 0.760 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr12_+_70618892 0.759 NM_173353
TPH2
tryptophan hydroxylase 2
chr4_-_279943 0.756 NM_001137608
ZNF732
zinc finger protein 732
chr3_+_101911051 0.751 NM_001195478
TFG
TRK-fused gene
chr4_-_83566045 0.751


chr10_+_28918672 0.750 WAC
WW domain containing adaptor with coiled-coil
chr10_+_24537725 0.749 NM_001098501
NM_019590
KIAA1217

KIAA1217

chr8_-_66863841 0.748 NM_002603
PDE7A
phosphodiesterase 7A
chr6_-_138862273 0.744


chr10_+_57028755 0.739 NM_001190478
MTRNR2L5
MT-RNR2-like 5
chr2_-_189363075 0.737 NM_052952
DIRC1
disrupted in renal carcinoma 1
chr6_-_7334940 0.732 NM_001170692
NM_001170693
NM_205864
CAGE1


cancer antigen 1


chr7_+_91762227 0.731


chr6_-_50039776 0.730 NM_001037499
DEFB114
defensin, beta 114
chr4_+_100714995 0.730 MTTP
microsomal triglyceride transfer protein
chr2_+_108751033 0.729 RANBP2
RAN binding protein 2
chr9_-_113561613 0.729 NM_001080551
C9orf84
chromosome 9 open reading frame 84
chr3_-_122862447 0.720 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr10_+_97749837 0.718 NM_001001732
NM_001159747
CC2D2B

coiled-coil and C2 domain containing 2B

chr11_-_82460518 0.712 RAB30
RAB30, member RAS oncogene family
chr6_-_123999640 0.710 NM_006073
TRDN
triadin
chr10_+_98730977 0.710 NM_015652
C10orf12
chromosome 10 open reading frame 12
chr12_+_61645361 0.708 RPL14
ribosomal protein L14
chr19_-_44920451 0.701 NM_001828
CLC
Charcot-Leyden crystal protein
chr14_-_106184988 0.700 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr11_-_82460531 0.697 NM_014488
RAB30
RAB30, member RAS oncogene family
chr5_-_95044415 0.697 NM_031952
SPATA9
spermatogenesis associated 9
chr2_+_170074457 0.695 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr12_-_73889481 0.692 KCNC2
potassium voltage-gated channel, Shaw-related subfamily, member 2
chr13_-_106018445 0.686 NM_018011
ARGLU1
arginine and glutamate rich 1
chr9_+_91115924 0.673 NM_001827
CKS2
CDC28 protein kinase regulatory subunit 2
chr14_-_74669864 0.673 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr3_+_63613383 0.666 NM_001080537
SNTN
sentan, cilia apical structure protein
chr2_-_37397669 0.666 NM_005813
PRKD3
protein kinase D3
chr4_-_170770111 0.664 NM_012224
NEK1
NIMA (never in mitosis gene a)-related kinase 1
chr9_-_74735669 0.662 ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr1_+_92405196 0.662 NM_015237
KIAA1107
KIAA1107
chr7_-_83108682 0.662 NM_001178129
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr1_+_110361634 0.661 AHCYL1
adenosylhomocysteinase-like 1
chr1_+_185064654 0.659 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr18_+_3443771 0.659 NM_173211
TGIF1
TGFB-induced factor homeobox 1
chr7_+_80145461 0.657 CD36
CD36 molecule (thrombospondin receptor)
chr6_-_133008834 0.654 NM_138327
TAAR1
trace amine associated receptor 1
chr15_+_49988882 0.649 TMOD3
tropomodulin 3 (ubiquitous)
chr7_+_111908143 0.647 NM_001134468
NM_182597
C7orf53

chromosome 7 open reading frame 53

chr1_-_177106702 0.647 NM_004673
ANGPTL1
angiopoietin-like 1
chr10_+_35496449 0.646 NM_182771
NM_182772
CREM

cAMP responsive element modulator

chr18_+_59295123 0.645 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr10_+_74323344 0.636 NM_152635
OIT3
oncoprotein induced transcript 3
chr8_+_17874128 0.635 PCM1
pericentriolar material 1
chr3_-_99236520 0.633 NM_001105580
GABRR3
gamma-aminobutyric acid (GABA) receptor, rho 3
chr3_+_51550635 0.633 NM_015106
RAD54L2
RAD54-like 2 (S. cerevisiae)
chr13_+_81162030 0.628


chr8_-_13018123 0.627 NM_001164271
DLC1
deleted in liver cancer 1
chr14_+_38719462 0.626 PNN
pinin, desmosome associated protein
chr1_+_57093030 0.617 NM_000562
C8A
complement component 8, alpha polypeptide
chr1_+_176577228 0.616 NM_004841
RASAL2
RAS protein activator like 2
chr22_-_39587944 0.615 NM_145174
DNAJB7
DnaJ (Hsp40) homolog, subfamily B, member 7
chrX_-_39921525 0.611 NM_001123383
NM_001123384
BCOR

BCL6 corepressor

chr12_-_11230809 0.610 NM_181429
TAS2R42
taste receptor, type 2, member 42
chr10_+_86121526 0.608 FAM190B
family with sequence similarity 190, member B
chr13_-_45323757 0.605 NM_198849
SIAH3
seven in absentia homolog 3 (Drosophila)
chr12_-_21649019 0.597 NM_021957
GYS2
glycogen synthase 2 (liver)
chr20_-_33783409 0.594 RBM39
RNA binding motif protein 39

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.23 1.93e-02 GO:0032501 multicellular organismal process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.64 1.36e-02 GO:0005626 insoluble fraction
1.44 2.38e-02 GO:0005856 cytoskeleton

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.68 9.38e-03 GO:0004930 G-protein coupled receptor activity