Motif ID: NKX2-3_NKX2-5.p2

Z-value: 1.105


Transcription factors associated with NKX2-3_NKX2-5.p2:

Gene SymbolEntrez IDGene Name
NKX2-3 159296 NK2 transcription factor related, locus 3 (Drosophila)
NKX2-5 1482 NK2 transcription factor related, locus 5 (Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-5chr5_-_1725946910.253.5e-01Click!
NKX2-3chr10_+_1012826790.136.4e-01Click!


Activity profile for motif NKX2-3_NKX2-5.p2.

activity profile for motif NKX2-3_NKX2-5.p2


Sorted Z-values histogram for motif NKX2-3_NKX2-5.p2

Sorted Z-values for motif NKX2-3_NKX2-5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-3_NKX2-5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_13992351 3.565 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr17_-_71285992 2.629 H3F3B
H3 histone, family 3B (H3.3B)
chr9_+_117955890 2.014 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr12_-_120725210 1.876 LOC338799
hypothetical LOC338799
chr7_-_27171673 1.802 NM_152739
HOXA9
homeobox A9
chr7_-_27171648 1.723 HOXA9
homeobox A9
chr7_-_27171600 1.647 HOXA9
homeobox A9
chr12_+_52696908 1.625 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr6_+_50789215 1.596 NM_172238
TFAP2D
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chr6_+_155579788 1.341 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr20_+_62266217 1.256 MYT1
myelin transcription factor 1
chr4_+_3341521 1.241 NM_198227
RGS12
regulator of G-protein signaling 12
chr1_+_50342168 1.207 NM_001144776
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr5_+_175041069 1.203 NM_022304
HRH2
histamine receptor H2
chr5_-_88155360 1.197 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr20_+_62266270 1.162 NM_004535
MYT1
myelin transcription factor 1
chr17_+_7682355 1.161


chr3_+_16191159 1.109 NM_054110
GALNTL2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 2
chr20_-_62052922 1.094 NM_001193379
UCKL1
uridine-cytidine kinase 1-like 1
chr22_+_38903825 1.090 NM_001162501
NM_015088
TNRC6B

trinucleotide repeat containing 6B

chr3_-_127810087 1.086 NM_001039783
TXNRD3IT1
thioredoxin reductase 3 intronic transcript 1
chr1_-_149681265 1.082 NM_207171
POGZ
pogo transposable element with ZNF domain
chr19_-_46504831 1.008


chr12_-_28016182 0.995 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr1_+_556968 0.991


chr17_-_36209672 0.987 NM_181535
KRT28
keratin 28
chr22_-_36836620 0.984 NM_025045
BAIAP2L2
BAI1-associated protein 2-like 2
chr13_-_93929719 0.964 NM_001129889
NM_001922
DCT

dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)

chr2_+_171280046 0.957 NM_001003845
SP5
Sp5 transcription factor
chr16_+_10878539 0.948 NM_000246
CIITA
class II, major histocompatibility complex, transactivator
chr6_-_33862690 0.890 NM_001143944
LEMD2
LEM domain containing 2
chr12_+_52697160 0.876 HOXC5
HOXC6
homeobox C5
homeobox C6
chr6_-_46401174 0.875 RCAN2
regulator of calcineurin 2
chr9_+_129900637 0.875 NM_052901
NM_001006643
SLC25A25

solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25

chr2_+_171280182 0.873


chr9_+_129900590 0.869 SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr4_-_38710376 0.863 NM_024943
TMEM156
transmembrane protein 156
chr14_+_91858677 0.849 NM_153648
SLC24A4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr22_-_36836478 0.815 BAIAP2L2
BAI1-associated protein 2-like 2
chr12_-_51233001 0.803 NM_033448
KRT71
keratin 71
chr13_-_35327798 0.797 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr14_-_100105883 0.786 NM_020836
BEGAIN
brain-enriched guanylate kinase-associated homolog (rat)
chr3_+_46894239 0.776 NM_000316
PTH1R
parathyroid hormone 1 receptor
chr15_-_64108718 0.773


chr6_+_16251260 0.767 MYLIP
myosin regulatory light chain interacting protein
chr1_+_203503214 0.748 TMCC2
transmembrane and coiled-coil domain family 2
chr17_-_1211263 0.741 YWHAE
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
chr17_-_76064842 0.736 NM_002522
NPTX1
neuronal pentraxin I
chr4_+_140806536 0.721 MGST2
microsomal glutathione S-transferase 2
chr3_-_152517204 0.706 NM_023915
GPR87
G protein-coupled receptor 87
chr5_+_169713458 0.693 NM_001034838
KCNIP1
Kv channel interacting protein 1
chr13_+_97856148 0.685


chr17_-_19290745 0.683


chr16_+_7322751 0.678 NM_145891
NM_145892
NM_145893
RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr3_+_69895651 0.676 NM_006722
MITF
microphthalmia-associated transcription factor
chr12_-_89922888 0.673 NM_004950
EPYC
epiphycan
chrX_-_18600108 0.670 NM_000330
RS1
retinoschisin 1
chr20_+_9146036 0.669 NM_182797
PLCB4
phospholipase C, beta 4
chr4_-_83566045 0.655


chr12_-_10173947 0.651 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr20_-_43163021 0.645 NM_002251
KCNS1
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1
chr11_+_7574992 0.644 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr2_+_161980865 0.643 NM_006593
TBR1
T-box, brain, 1
chr17_+_56843893 0.637 NM_203425
C17orf82
chromosome 17 open reading frame 82
chr1_-_149004852 0.633 CTSS
cathepsin S
chr4_+_9094611 0.633 NM_001040071
LOC650293
seven transmembrane helix receptor
chr4_-_153493133 0.630 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr22_-_43987010 0.627 NM_015264
KIAA0930
KIAA0930
chr6_+_134800533 0.626 LOC154092
hypothetical LOC154092
chr1_+_17817397 0.622 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr14_+_31868229 0.614 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr7_-_115458047 0.609 TFEC
transcription factor EC
chr16_-_21571463 0.609 NM_005849
IGSF6
immunoglobulin superfamily, member 6
chrX_-_19598912 0.600 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr13_+_26896614 0.600 NM_002097
GTF3A
general transcription factor IIIA
chr4_-_83566246 0.588 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr11_+_91724909 0.583 NM_001008781
FAT3
FAT tumor suppressor homolog 3 (Drosophila)
chr16_-_21571409 0.582 IGSF6
immunoglobulin superfamily, member 6
chr12_-_51200347 0.582 NM_000424
KRT5
keratin 5
chr7_+_113842284 0.573 NM_001172766
NM_014491
NM_148898
NM_148900
FOXP2



forkhead box P2



chr19_-_13925192 0.571 NM_001146254
NM_001146255
PODNL1

podocan-like 1

chr8_-_102029997 0.569 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr20_+_31713750 0.567 NM_080825
C20orf144
chromosome 20 open reading frame 144
chr1_+_166516901 0.565 NM_005149
TBX19
T-box 19
chr10_-_32707549 0.561 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr9_+_130909926 0.545


chr6_-_86407875 0.536 NM_001159675
NM_001159676
SYNCRIP

synaptotagmin binding, cytoplasmic RNA interacting protein

chr2_+_158559936 0.536 NM_001135098
UPP2
uridine phosphorylase 2
chr6_-_74284522 0.533 EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr7_-_75794919 0.533 YWHAG
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
chr19_+_50100843 0.530 NM_000041
APOE
apolipoprotein E
chr13_-_37070862 0.529 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr2_-_20375497 0.527 PUM2
pumilio homolog 2 (Drosophila)
chr18_+_71051713 0.525 NM_005786
TSHZ1
teashirt zinc finger homeobox 1
chr6_+_50894397 0.525 NM_003221
TFAP2B
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
chr2_-_215953818 0.524 FN1
fibronectin 1
chr7_-_115458010 0.523 NM_001018058
NM_012252
TFEC

transcription factor EC

chr1_-_180624380 0.522 GLUL
glutamate-ammonia ligase
chr20_+_31287462 0.517 NM_016583
NM_130852
PLUNC

palate, lung and nasal epithelium associated

chrX_+_70682204 0.517 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr10_+_44726635 0.514 NM_001123376
TMEM72
transmembrane protein 72
chr6_+_12824873 0.508 PHACTR1
phosphatase and actin regulator 1
chr17_-_36346240 0.507 KRT23
keratin 23 (histone deacetylase inducible)
chr6_+_12825022 0.502 PHACTR1
phosphatase and actin regulator 1
chr2_+_173394560 0.496 NM_001100397
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr12_-_51173238 0.495 NM_005554
KRT6A
keratin 6A
chr6_-_2580296 0.487 NM_152554
C6orf195
chromosome 6 open reading frame 195
chr4_+_71713324 0.485 NM_031889
ENAM
enamelin
chr17_+_72065440 0.482 LOC100507246
hypothetical LOC100507246
chr10_+_80743769 0.481 ZMIZ1
zinc finger, MIZ-type containing 1
chr7_-_41709191 0.478 NM_002192
INHBA
inhibin, beta A
chr11_+_20001130 0.462 NM_001111019
NAV2
neuron navigator 2
chr10_+_124660206 0.461 NM_001029888
FAM24A
family with sequence similarity 24, member A
chr1_+_149299490 0.456 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr10_+_71833920 0.455 EIF4EBP2
eukaryotic translation initiation factor 4E binding protein 2
chr7_+_141054621 0.453 NM_001105558
WEE2
WEE1 homolog 2 (S. pombe)
chr1_+_938709 0.449 NM_005101
ISG15
ISG15 ubiquitin-like modifier
chr9_-_205892 0.447 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr15_+_91244563 0.446 CHD2
chromodomain helicase DNA binding protein 2
chr18_-_13905534 0.445 NM_000529
MC2R
melanocortin 2 receptor (adrenocorticotropic hormone)
chr6_-_169395847 0.444 THBS2
thrombospondin 2
chr17_+_72982919 0.437 NM_001113495
SEPT9
septin 9
chr8_-_17624009 0.436 NM_001001931
MTUS1
microtubule associated tumor suppressor 1
chr9_-_133574928 0.435 NM_198679
RAPGEF1
Rap guanine nucleotide exchange factor (GEF) 1
chr20_-_49747397 0.434 ATP9A
ATPase, class II, type 9A
chr1_-_53972464 0.433 NM_147193
GLIS1
GLIS family zinc finger 1
chr15_+_97990705 0.431 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr1_+_154449389 0.431 NM_007221
PMF1-BGLAP
PMF1
PMF1-BGLAP read-through transcript
polyamine-modulated factor 1
chrX_+_21960841 0.430 NM_000444
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr2_-_190635566 0.429 NM_005259
MSTN
myostatin
chr8_-_72436519 0.428 EYA1
eyes absent homolog 1 (Drosophila)
chr6_-_52882419 0.423 NM_000847
GSTA3
glutathione S-transferase alpha 3
chr22_-_16127520 0.421 CECR3
cat eye syndrome chromosome region, candidate 3
chr7_-_104696678 0.419 NM_182691
SRPK2
SRSF protein kinase 2
chr2_+_161981138 0.417 TBR1
T-box, brain, 1
chr4_+_155703581 0.415 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr16_-_20246309 0.415 NM_001007240
NM_001007241
NM_001007242
NM_001502
GP2



glycoprotein 2 (zymogen granule membrane)



chr8_+_55691179 0.413 NM_006269
RP1
retinitis pigmentosa 1 (autosomal dominant)
chr10_+_71833905 0.410 EIF4EBP2
eukaryotic translation initiation factor 4E binding protein 2
chr11_-_2108035 0.409 IGF2
insulin-like growth factor 2 (somatomedin A)
chr17_+_54587882 0.408 PRR11
proline rich 11
chr1_+_208568218 0.407 NM_001122834
NM_001170564
HHAT

hedgehog acyltransferase

chr1_+_149299530 0.406 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr6_+_37081387 0.405 NM_173558
FGD2
FYVE, RhoGEF and PH domain containing 2
chr11_-_46364681 0.404 NM_000741
CHRM4
cholinergic receptor, muscarinic 4
chr3_-_55489973 0.404 WNT5A
wingless-type MMTV integration site family, member 5A
chr2_+_161981046 0.402 TBR1
T-box, brain, 1
chr5_+_174084137 0.402 NM_002449
MSX2
msh homeobox 2
chr12_-_9913199 0.402 CLEC2B
C-type lectin domain family 2, member B
chr16_+_20682812 0.398 NM_005622
NM_202000
ACSM3

acyl-CoA synthetase medium-chain family member 3

chr1_+_559129 0.397


chr20_-_7869068 0.395 NM_017545
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr7_+_129771865 0.393 NM_001127441
NM_001127442
NM_080385
CPA5


carboxypeptidase A5


chr4_-_176970895 0.393 GPM6A
glycoprotein M6A
chr17_-_10393664 0.391 NM_001100112
NM_017534
MYH2

myosin, heavy chain 2, skeletal muscle, adult

chr20_-_1921451 0.390 NM_001190892
PDYN
prodynorphin
chr12_-_88269884 0.386 DUSP6
dual specificity phosphatase 6
chr1_+_149299504 0.386 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr6_-_46401363 0.385 NM_005822
RCAN2
regulator of calcineurin 2
chrX_+_68752635 0.383 NM_001005609
NM_001005610
NM_001005612
NM_001005613
NM_001399
EDA




ectodysplasin A




chr2_-_178681311 0.382 NM_001077197
PDE11A
phosphodiesterase 11A
chr11_+_65023218 0.380


chr8_-_122722674 0.380 NM_005328
HAS2
hyaluronan synthase 2
chr14_+_99633570 0.379 EVL
Enah/Vasp-like
chr10_+_111755715 0.378 NM_019903
ADD3
adducin 3 (gamma)
chr11_+_128067598 0.378 NM_001167681
FLI1
Friend leukemia virus integration 1
chr4_+_71418886 0.373 NM_212557
AMTN
amelotin
chr6_+_158653679 0.372 NM_001007466
NM_020245
TULP4

tubby like protein 4

chrX_+_90976314 0.372 NM_014522
NM_032968
NM_032969
PCDH11X


protocadherin 11 X-linked


chr6_+_152168500 0.371 NM_001122741
ESR1
estrogen receptor 1
chr4_+_71142893 0.368 NM_005212
CSN3
casein kappa
chr3_-_188935363 0.366 NM_001134738
BCL6
B-cell CLL/lymphoma 6
chr16_+_79829794 0.366 NM_017429
BCMO1
beta-carotene 15,15'-monooxygenase 1
chr3_+_160269836 0.363 IQCJ
IQ motif containing J
chr3_+_8750485 0.362 NM_033337
NM_001234
CAV3

caveolin 3

chr20_+_43691797 0.361 NM_080753
WFDC10A
WAP four-disulfide core domain 10A
chr12_+_12829807 0.361 NM_030817
APOLD1
apolipoprotein L domain containing 1
chr12_+_48443232 0.359 TMBIM6
transmembrane BAX inhibitor motif containing 6
chr5_+_71538456 0.359 MAP1B
microtubule-associated protein 1B
chr5_+_1278469 0.357 NM_182632
SLC6A18
solute carrier family 6, member 18
chr17_-_64649608 0.356 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr3_-_11585264 0.354 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr20_+_19863716 0.350 RIN2
Ras and Rab interactor 2
chr11_+_65026382 0.350


chr17_+_38412267 0.350 NM_005533
IFI35
interferon-induced protein 35
chr10_-_105835609 0.347 NM_000494
COL17A1
collagen, type XVII, alpha 1
chr3_+_160269734 0.347 NM_001197113
NM_001197114
NM_001042705
NM_001042706
NM_001197100
IQCJ-SCHIP1

IQCJ


IQCJ-SCHIP1 readthrough

IQ motif containing J


chr2_+_220017617 0.346 SPEG
SPEG complex locus
chr1_-_180624494 0.344 GLUL
glutamate-ammonia ligase
chr10_-_97190885 0.343 NM_001034954
NM_001034955
NM_001034956
NM_001034957
NM_006434
SORBS1




sorbin and SH3 domain containing 1




chr20_-_21442663 0.343 NM_002509
NKX2-2
NK2 homeobox 2
chr1_-_109957195 0.342 NM_005272
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr2_-_160764819 0.340 NM_000888
ITGB6
integrin, beta 6
chr10_+_71833866 0.340 NM_004096
EIF4EBP2
eukaryotic translation initiation factor 4E binding protein 2
chr9_-_135379888 0.337 NM_001080483
TMEM8C
transmembrane protein 8C
chr2_+_157822355 0.336 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr1_+_557269 0.336


chr10_-_64246129 0.334 NM_000399
NM_001136177
NM_001136179
EGR2


early growth response 2


chr6_-_169395972 0.333 NM_003247
THBS2
thrombospondin 2
chr3_-_139960874 0.332 NM_006219
PIK3CB
phosphoinositide-3-kinase, catalytic, beta polypeptide

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.41 4.36e-11 GO:0032501 multicellular organismal process
1.43 2.83e-06 GO:0007275 multicellular organismal development
1.40 3.70e-06 GO:0032502 developmental process
1.48 4.94e-06 GO:0048731 system development
1.44 8.44e-06 GO:0048856 anatomical structure development
1.59 6.54e-05 GO:0007166 cell surface receptor linked signaling pathway
1.55 1.95e-04 GO:0048513 organ development
1.34 6.24e-04 GO:0023052 signaling
1.31 1.58e-03 GO:0051716 cellular response to stimulus
1.35 1.60e-03 GO:0007165 signal transduction
1.75 5.74e-03 GO:0009888 tissue development
1.22 6.78e-03 GO:0050896 response to stimulus
3.82 7.28e-03 GO:0048706 embryonic skeletal system development
1.17 7.53e-03 GO:0065007 biological regulation
2.67 1.09e-02 GO:0007517 muscle organ development
1.76 1.86e-02 GO:0007267 cell-cell signaling
5.39 2.10e-02 GO:0071363 cellular response to growth factor stimulus
1.18 2.46e-02 GO:0050794 regulation of cellular process
4.44 2.47e-02 GO:0070848 response to growth factor stimulus
1.51 2.50e-02 GO:0009653 anatomical structure morphogenesis
1.46 2.70e-02 GO:0003008 system process
11.80 4.70e-02 GO:0007603 phototransduction, visible light

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.54 5.63e-06 GO:0005576 extracellular region
1.80 6.43e-06 GO:0044421 extracellular region part
1.83 1.22e-04 GO:0005615 extracellular space
1.24 1.55e-02 GO:0071944 cell periphery
1.24 2.01e-02 GO:0005886 plasma membrane
3.99 2.24e-02 GO:0031983 vesicle lumen

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.84 1.14e-03 GO:0043565 sequence-specific DNA binding
2.73 5.58e-03 GO:0008083 growth factor activity
1.61 7.82e-03 GO:0030528 transcription regulator activity
1.58 2.14e-02 GO:0001071 nucleic acid binding transcription factor activity
1.58 2.14e-02 GO:0003700 sequence-specific DNA binding transcription factor activity
3.78 3.05e-02 GO:0035591 signaling adaptor activity