Motif ID: NKX2-3_NKX2-5.p2

Z-value: 1.105


Transcription factors associated with NKX2-3_NKX2-5.p2:

Gene SymbolEntrez IDGene Name
NKX2-3 159296 NK2 transcription factor related, locus 3 (Drosophila)
NKX2-5 1482 NK2 transcription factor related, locus 5 (Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-5chr5_-_1725946910.253.5e-01Click!
NKX2-3chr10_+_1012826790.136.4e-01Click!


Activity profile for motif NKX2-3_NKX2-5.p2.

activity profile for motif NKX2-3_NKX2-5.p2


Sorted Z-values histogram for motif NKX2-3_NKX2-5.p2

Sorted Z-values for motif NKX2-3_NKX2-5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-3_NKX2-5.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_13992351 3.565 NM_001163150
NM_001163151
NM_001163152
 ETV1


ets variant 1


chr17_-_71285992 2.629 H3F3B
H3 histone, family 3B (H3.3B)
chr9_+_117955890 2.014 NM_002581
 PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr12_-_120725210 1.876 LOC338799
hypothetical LOC338799
chr7_-_27171673 1.802 NM_152739
 HOXA9
homeobox A9
chr7_-_27171648 1.723 HOXA9
homeobox A9
chr7_-_27171600 1.647 HOXA9
homeobox A9
chr12_+_52696908 1.625 NM_014620
NM_153693
 HOXC4
HOXC6
homeobox C4
homeobox C6
chr6_+_50789215 1.596 NM_172238
 TFAP2D
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chr6_+_155579788 1.341 NM_001010927
 TIAM2
T-cell lymphoma invasion and metastasis 2
chr20_+_62266217 1.256 MYT1
myelin transcription factor 1
chr4_+_3341521 1.241 NM_198227
 RGS12
regulator of G-protein signaling 12
chr1_+_50342168 1.207 NM_001144776
 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr5_+_175041069 1.203 NM_022304
 HRH2
histamine receptor H2
chr5_-_88155360 1.197 NM_001193348
NM_001193349
 MEF2C

myocyte enhancer factor 2C

chr20_+_62266270 1.162 NM_004535
 MYT1
myelin transcription factor 1
chr17_+_7682355 1.161


chr3_+_16191159 1.109 NM_054110
 GALNTL2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 2
chr20_-_62052922 1.094 NM_001193379
 UCKL1
uridine-cytidine kinase 1-like 1
chr22_+_38903825 1.090 NM_001162501
NM_015088
 TNRC6B

trinucleotide repeat containing 6B


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 22 entries
enrichment   p-value GO term description
11.80 4.70e-02 GO:0007603 phototransduction, visible light
5.39 2.10e-02 GO:0071363 cellular response to growth factor stimulus
4.44 2.47e-02 GO:0070848 response to growth factor stimulus
3.82 7.28e-03 GO:0048706 embryonic skeletal system development
2.67 1.09e-02 GO:0007517 muscle organ development
1.76 1.86e-02 GO:0007267 cell-cell signaling
1.75 5.74e-03 GO:0009888 tissue development
1.59 6.54e-05 GO:0007166 cell surface receptor linked signaling pathway
1.55 1.95e-04 GO:0048513 organ development
1.51 2.50e-02 GO:0009653 anatomical structure morphogenesis
1.48 4.94e-06 GO:0048731 system development
1.46 2.70e-02 GO:0003008 system process
1.44 8.44e-06 GO:0048856 anatomical structure development
1.43 2.83e-06 GO:0007275 multicellular organismal development
1.41 4.36e-11 GO:0032501 multicellular organismal process
1.40 3.70e-06 GO:0032502 developmental process
1.35 1.60e-03 GO:0007165 signal transduction
1.34 6.24e-04 GO:0023052 signaling
1.31 1.58e-03 GO:0051716 cellular response to stimulus
1.22 6.78e-03 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

Showing 1 to 6 of 6 entries
enrichment   p-value GO term description
3.99 2.24e-02 GO:0031983 vesicle lumen
1.83 1.22e-04 GO:0005615 extracellular space
1.80 6.43e-06 GO:0044421 extracellular region part
1.54 5.63e-06 GO:0005576 extracellular region
1.24 1.55e-02 GO:0071944 cell periphery
1.24 2.01e-02 GO:0005886 plasma membrane

Gene overrepresentation in function category:

Showing 1 to 6 of 6 entries
enrichment   p-value GO term description
3.78 3.05e-02 GO:0035591 signaling adaptor activity
2.73 5.58e-03 GO:0008083 growth factor activity
1.84 1.14e-03 GO:0043565 sequence-specific DNA binding
1.61 7.82e-03 GO:0030528 transcription regulator activity
1.58 2.14e-02 GO:0001071 nucleic acid binding transcription factor activity
1.58 2.14e-02 GO:0003700 sequence-specific DNA binding transcription factor activity