Motif ID: NKX3-2.p2

Z-value: 1.608


Transcription factors associated with NKX3-2.p2:

Gene SymbolEntrez IDGene Name
NKX3-2 579 NK3 homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX3-2chr4_-_131551350.175.2e-01Click!


Activity profile for motif NKX3-2.p2.

activity profile for motif NKX3-2.p2


Sorted Z-values histogram for motif NKX3-2.p2

Sorted Z-values for motif NKX3-2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX3-2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_225973845 1.366 NM_020864
 KIAA1486
KIAA1486
chr3_-_188936941 1.286 NM_001130845
 BCL6
B-cell CLL/lymphoma 6
chr10_+_4995453 1.198 NM_001353
 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr2_-_162717159 1.196 NM_002054
 GCG
glucagon
chr2_+_218790109 1.159 NM_152862
 ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr13_+_75232797 1.139 NM_015842
 LMO7
LIM domain 7
chr2_+_218790159 1.126 ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr2_-_109728958 1.084 NM_144710
NM_178584
 SEPT10

septin 10

chr2_+_228386800 1.084 NM_001130046
NM_004591
 CCL20

chemokine (C-C motif) ligand 20

chr8_+_32905027 1.080


chr14_+_30098079 1.056 NM_017769
 G2E3
G2/M-phase specific E3 ubiquitin protein ligase
chr8_-_122722674 1.037 NM_005328
 HAS2
hyaluronan synthase 2
chr6_+_117910472 1.022 NM_173674
 DCBLD1
discoidin, CUB and LCCL domain containing 1
chr2_+_109729176 1.015 NM_023016
 ANKRD57
ankyrin repeat domain 57
chr8_+_120289735 1.013 NM_052886
 MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr2_+_54638957 1.007 NM_178313
 SPTBN1
spectrin, beta, non-erythrocytic 1
chr2_+_218790364 0.936 NM_005731
 ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr10_+_98582648 0.923 NM_032440
 LCOR
ligand dependent nuclear receptor corepressor
chr14_-_22610610 0.910 NM_001164816
NM_001164817
 ACIN1

apoptotic chromatin condensation inducer 1

chr13_+_25726755 0.910 NM_001260
 CDK8
cyclin-dependent kinase 8

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 12 of 12 entries
enrichment   p-value GO term description
1.48 6.77e-03 GO:0042060 wound healing
1.40 3.25e-02 GO:0006915 apoptosis
1.39 4.95e-02 GO:0012501 programmed cell death
1.37 1.53e-02 GO:0016265 death
1.37 1.69e-02 GO:0008219 cell death
1.35 4.12e-02 GO:0009611 response to wounding
1.32 2.72e-02 GO:0010646 regulation of cell communication
1.22 2.17e-02 GO:0048523 negative regulation of cellular process
1.22 3.46e-02 GO:0048869 cellular developmental process
1.21 1.65e-02 GO:0048519 negative regulation of biological process
1.14 3.20e-02 GO:0044260 cellular macromolecule metabolic process
1.06 3.95e-02 GO:0009987 cellular process

Gene overrepresentation in compartment category:

Showing 1 to 12 of 12 entries
enrichment   p-value GO term description
2.26 2.92e-02 GO:0031256 leading edge membrane
1.79 6.21e-03 GO:0031252 cell leading edge
1.10 6.09e-05 GO:0005737 cytoplasm
1.10 4.49e-02 GO:0044444 cytoplasmic part
1.08 1.52e-06 GO:0044424 intracellular part
1.08 2.57e-06 GO:0005622 intracellular
1.08 2.39e-03 GO:0043231 intracellular membrane-bounded organelle
1.08 3.18e-03 GO:0043227 membrane-bounded organelle
1.07 3.11e-03 GO:0043226 organelle
1.07 3.33e-03 GO:0043229 intracellular organelle
1.03 2.97e-02 GO:0005623 cell
1.03 3.68e-02 GO:0044464 cell part

Gene overrepresentation in function category:

Showing 1 to 2 of 2 entries
enrichment   p-value GO term description
1.15 1.36e-09 GO:0005515 protein binding
1.07 2.20e-05 GO:0005488 binding