Motif ID: NKX3-2.p2

Z-value: 1.608


Transcription factors associated with NKX3-2.p2:

Gene SymbolEntrez IDGene Name
NKX3-2 579 NK3 homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX3-2chr4_-_131551350.175.2e-01Click!


Activity profile for motif NKX3-2.p2.

activity profile for motif NKX3-2.p2


Sorted Z-values histogram for motif NKX3-2.p2

Sorted Z-values for motif NKX3-2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX3-2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_225973845 1.366 NM_020864
KIAA1486
KIAA1486
chr3_-_188936941 1.286 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chr10_+_4995453 1.198 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr2_-_162717159 1.196 NM_002054
GCG
glucagon
chr2_+_218790109 1.159 NM_152862
ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr13_+_75232797 1.139 NM_015842
LMO7
LIM domain 7
chr2_+_218790159 1.126 ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr2_-_109728958 1.084 NM_144710
NM_178584
SEPT10

septin 10

chr2_+_228386800 1.084 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr8_+_32905027 1.080


chr14_+_30098079 1.056 NM_017769
G2E3
G2/M-phase specific E3 ubiquitin protein ligase
chr8_-_122722674 1.037 NM_005328
HAS2
hyaluronan synthase 2
chr6_+_117910472 1.022 NM_173674
DCBLD1
discoidin, CUB and LCCL domain containing 1
chr2_+_109729176 1.015 NM_023016
ANKRD57
ankyrin repeat domain 57
chr8_+_120289735 1.013 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr2_+_54638957 1.007 NM_178313
SPTBN1
spectrin, beta, non-erythrocytic 1
chr2_+_218790364 0.936 NM_005731
ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr10_+_98582648 0.923 NM_032440
LCOR
ligand dependent nuclear receptor corepressor
chr14_-_22610610 0.910 NM_001164816
NM_001164817
ACIN1

apoptotic chromatin condensation inducer 1

chr13_+_25726755 0.910 NM_001260
CDK8
cyclin-dependent kinase 8
chr2_+_171280944 0.863 SP5
Sp5 transcription factor
chr20_+_56904042 0.858 GNAS
GNAS complex locus
chr1_-_7998265 0.843 ERRFI1
ERBB receptor feedback inhibitor 1
chr2_+_219141761 0.839 NM_005444
RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr3_+_69216747 0.838 NM_006407
ARL6IP5
ADP-ribosylation-like factor 6 interacting protein 5
chr17_-_7996409 0.830 NM_002616
PER1
period homolog 1 (Drosophila)
chr9_+_6318348 0.824 NM_001001874
NM_001001875
NM_033516
TPD52L3


tumor protein D52-like 3


chr14_-_22610572 0.807 ACIN1
apoptotic chromatin condensation inducer 1
chr16_+_55963899 0.802 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr3_+_138159396 0.802 NM_144717
IL20RB
interleukin 20 receptor beta
chr2_-_37727472 0.780 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr3_-_192063158 0.778 NM_001146686
GEMC1
geminin coiled-coil domain-containing protein 1
chr16_+_55963883 0.774 CX3CL1
chemokine (C-X3-C motif) ligand 1
chr3_+_134978615 0.774 TF
transferrin
chr12_+_79995927 0.762 NM_024560
ACSS3
acyl-CoA synthetase short-chain family member 3
chr2_+_86521939 0.761 KDM3A
lysine (K)-specific demethylase 3A
chr2_+_201099093 0.756 NM_001160033
NM_001160046
NM_152524
SGOL2


shugoshin-like 2 (S. pombe)


chr2_+_17585462 0.749 VSNL1
visinin-like 1
chr16_-_80602546 0.746 NM_145168
SDR42E1
short chain dehydrogenase/reductase family 42E, member 1
chr2_+_28828332 0.746 PPP1CB
protein phosphatase 1, catalytic subunit, beta isozyme
chr6_+_131190237 0.741 NM_001195597
LOC285733
hypothetical LOC285733
chr2_+_86521999 0.736 NM_001146688
KDM3A
lysine (K)-specific demethylase 3A
chr2_+_207215386 0.736 NM_001102659
LOC200726
hCG1657980
chr17_+_64020120 0.725 NM_002734
NM_212472
PRKAR1A

protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)

chr3_+_112273352 0.721 PVRL3
poliovirus receptor-related 3
chr14_+_38714111 0.708 NM_002687
PNN
pinin, desmosome associated protein
chr16_+_55523526 0.705 HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr17_+_64020155 0.703 PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
chr5_+_38882017 0.703 OSMR
oncostatin M receptor
chr2_-_148495642 0.696 NM_181742
ORC4
origin recognition complex, subunit 4
chr4_-_163304567 0.691 NM_001128427
NM_001128428
NM_020116
FSTL5


follistatin-like 5


chr5_+_96297101 0.687 NM_005575
LNPEP
leucyl/cystinyl aminopeptidase
chr17_+_64020159 0.683 PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
chr3_-_188935363 0.683 NM_001134738
BCL6
B-cell CLL/lymphoma 6
chr2_-_21079145 0.675 APOB
apolipoprotein B (including Ag(x) antigen)
chr21_-_26345294 0.668


chr9_+_89302239 0.662 DAPK1
death-associated protein kinase 1
chr8_+_123863169 0.661 ZHX2
zinc fingers and homeoboxes 2
chr10_-_98311813 0.660 TM9SF3
transmembrane 9 superfamily member 3
chr3_+_61522922 0.657 PTPRG
protein tyrosine phosphatase, receptor type, G
chr6_-_123999640 0.652 NM_006073
TRDN
triadin
chr2_-_74460933 0.647 NM_001135040
NM_001190837
NM_004082
DCTN1


dynactin 1


chr4_+_95592067 0.645 PDLIM5
PDZ and LIM domain 5
chr2_+_187163232 0.639 ITGAV
integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
chr2_+_37282516 0.639 LOC100505876
hypothetical LOC100505876
chr14_-_23878871 0.639 NM_006871
RIPK3
receptor-interacting serine-threonine kinase 3
chr20_+_61622985 0.635 PPDPF
pancreatic progenitor cell differentiation and proliferation factor homolog (zebrafish)
chr3_+_187813538 0.626 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr14_-_24115268 0.624 NM_001911
CTSG
cathepsin G
chr22_+_27994216 0.624 EWSR1
Ewing sarcoma breakpoint region 1
chr14_+_34831294 0.623 NM_002791
PSMA6
proteasome (prosome, macropain) subunit, alpha type, 6
chr3_+_48482213 0.622 NM_016381
NM_033629
TREX1

three prime repair exonuclease 1

chr8_+_123863075 0.617 NM_014943
ZHX2
zinc fingers and homeoboxes 2
chr10_-_90702490 0.615 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr20_+_2309553 0.612 NM_198994
TGM6
transglutaminase 6
chr12_+_67426225 0.612 SLC35E3
solute carrier family 35, member E3
chr2_+_228064531 0.612 AGFG1
ArfGAP with FG repeats 1
chr10_+_123862430 0.609 TACC2
transforming, acidic coiled-coil containing protein 2
chr14_+_34831355 0.605 PSMA6
proteasome (prosome, macropain) subunit, alpha type, 6
chr1_+_35507197 0.599 ZMYM4
zinc finger, MYM-type 4
chr14_+_69303614 0.595 SRSF5
serine/arginine-rich splicing factor 5
chr7_+_94130752 0.591 PEG10
paternally expressed 10
chr16_+_31105579 0.588


chr2_+_196229715 0.588 NM_001127257
SLC39A10
solute carrier family 39 (zinc transporter), member 10
chr1_+_107485071 0.588 NTNG1
netrin G1
chr9_+_2612052 0.586 VLDLR
very low density lipoprotein receptor
chr4_+_95592030 0.583 NM_001011513
NM_001011515
NM_001011516
NM_006457
PDLIM5



PDZ and LIM domain 5



chr13_+_25726238 0.582 CDK8
cyclin-dependent kinase 8
chr14_+_69303563 0.580 SRSF5
serine/arginine-rich splicing factor 5
chr14_+_69303556 0.579 SRSF5
serine/arginine-rich splicing factor 5
chr2_-_191724169 0.579 NM_003151
STAT4
signal transducer and activator of transcription 4
chr5_+_72179749 0.576 TNPO1
transportin 1
chr20_+_45564063 0.575 NCOA3
nuclear receptor coactivator 3
chr14_+_69303615 0.575 SRSF5
serine/arginine-rich splicing factor 5
chr2_+_28828112 0.573 NM_206876
NM_002709
PPP1CB

protein phosphatase 1, catalytic subunit, beta isozyme

chr4_+_109761170 0.570 NM_000995
NM_033625
RPL34

ribosomal protein L34

chr3_+_187813405 0.569 AHSG
alpha-2-HS-glycoprotein
chr2_+_218790143 0.569 ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr14_+_69303633 0.569 SRSF5
serine/arginine-rich splicing factor 5
chr14_+_23633101 0.564 NM_001018073
NM_004563
PCK2

phosphoenolpyruvate carboxykinase 2 (mitochondrial)

chr14_+_69303565 0.564 NM_001039465
NM_006925
SRSF5

serine/arginine-rich splicing factor 5

chr11_-_2113297 0.563 IGF2
insulin-like growth factor 2 (somatomedin A)
chr12_+_99391870 0.563 NR1H4
nuclear receptor subfamily 1, group H, member 4
chr5_+_146594718 0.563 NM_001112724
NM_145001
STK32A

serine/threonine kinase 32A

chr6_+_7052798 0.553 NM_001168344
RREB1
ras responsive element binding protein 1
chr6_+_160068598 0.552 NM_152857
WTAP
Wilms tumor 1 associated protein
chr3_+_120375053 0.548 NM_006952
UPK1B
uroplakin 1B
chr10_+_42953886 0.547 NM_018590
CSGALNACT2
chondroitin sulfate N-acetylgalactosaminyltransferase 2
chr14_+_61653827 0.546 FLJ43390
hypothetical LOC646113
chr13_+_40783340 0.545 NM_001110798
NM_024561
NM_018527
NAA16


N(alpha)-acetyltransferase 16, NatA auxiliary subunit


chr21_-_26294332 0.544 APP
amyloid beta (A4) precursor protein
chr5_+_56507029 0.542 NM_001127235
GPBP1
GC-rich promoter binding protein 1
chr7_+_77004686 0.539 NM_002835
PTPN12
protein tyrosine phosphatase, non-receptor type 12
chr16_-_69271428 0.538 MTSS1L
metastasis suppressor 1-like
chr2_-_109728693 0.537 SEPT10
septin 10
chr7_+_94130673 0.535 PEG10
paternally expressed 10
chr7_-_102000072 0.534 POLR2J2
POLR2J3
polymerase (RNA) II (DNA directed) polypeptide J2
polymerase (RNA) II (DNA directed) polypeptide J3
chr22_+_27993997 0.533 NM_001163285
NM_001163286
NM_001163287
NM_005243
NM_013986
EWSR1




Ewing sarcoma breakpoint region 1




chr14_-_23874083 0.531 NM_001198568
NM_001198592
NM_139247
ADCY4


adenylate cyclase 4


chr22_-_27993933 0.531 RHBDD3
rhomboid domain containing 3
chr3_+_187813553 0.530 AHSG
alpha-2-HS-glycoprotein
chr5_+_52812236 0.527 NM_006350
NM_013409
FST

follistatin

chr13_-_110066694 0.526


chr2_+_200879040 0.525 NM_001100422
NM_001100424
NM_001100423
SPATS2L


spermatogenesis associated, serine-rich 2-like


chr2_-_21084077 0.524 APOB
apolipoprotein B (including Ag(x) antigen)
chr3_+_50101428 0.523 RBM5
RNA binding motif protein 5
chr17_+_8279860 0.521 NM_001025579
NM_030808
NDEL1

nudE nuclear distribution gene E homolog (A. nidulans)-like 1

chr22_+_33983444 0.520 NM_001003681
HMGXB4
HMG box domain containing 4
chr15_+_65145248 0.520 NM_005902
SMAD3
SMAD family member 3
chr20_+_45564007 0.519 NM_001174087
NM_001174088
NM_006534
NM_181659
NCOA3



nuclear receptor coactivator 3



chr17_+_11864841 0.519 NM_003010
MAP2K4
mitogen-activated protein kinase kinase 4
chr16_-_45562840 0.518 DNAJA2
DnaJ (Hsp40) homolog, subfamily A, member 2
chr11_+_34894688 0.516 PDHX
pyruvate dehydrogenase complex, component X
chr16_+_73739890 0.516 NM_153688
ZFP1
zinc finger protein 1 homolog (mouse)
chr14_+_54238581 0.509 SAMD4A
sterile alpha motif domain containing 4A
chr12_+_12857516 0.507 NM_016355
NM_201224
DDX47

DEAD (Asp-Glu-Ala-Asp) box polypeptide 47

chr20_-_1486303 0.505 NM_178460
SIRPD
signal-regulatory protein delta
chr15_+_65145215 0.505 SMAD3
SMAD family member 3
chr11_-_10630408 0.504 NM_001098579
MRVI1
murine retrovirus integration site 1 homolog
chr4_+_74520796 0.504 NM_001134
AFP
alpha-fetoprotein
chr10_+_5126589 0.501 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr16_+_49139694 0.500 NM_033119
NKD1
naked cuticle homolog 1 (Drosophila)
chr17_+_43082273 0.500 NM_002265
KPNB1
karyopherin (importin) beta 1
chr14_-_23117614 0.498 JPH4
junctophilin 4
chr3_+_58452560 0.497 NM_001128214
KCTD6
potassium channel tetramerisation domain containing 6
chr3_+_48482625 0.497 TREX1
three prime repair exonuclease 1
chr2_-_197499584 0.497 NM_024989
PGAP1
post-GPI attachment to proteins 1
chr14_+_54104383 0.497 NM_001161576
NM_015589
SAMD4A

sterile alpha motif domain containing 4A

chr14_+_75687997 0.496 NM_017926
NM_017972
C14orf118

chromosome 14 open reading frame 118

chr8_-_125785611 0.494 MTSS1
metastasis suppressor 1
chr6_+_160068544 0.489 WTAP
Wilms tumor 1 associated protein
chr11_+_65023218 0.489


chr3_+_50101355 0.488 NM_005778
RBM5
RNA binding motif protein 5
chr14_+_52243645 0.486 NM_002806
PSMC6
proteasome (prosome, macropain) 26S subunit, ATPase, 6
chr20_+_33750645 0.484 NM_080748
ROMO1
reactive oxygen species modulator 1
chr2_-_191723978 0.483 STAT4
signal transducer and activator of transcription 4
chr2_-_241903657 0.483 HDLBP
high density lipoprotein binding protein
chr2_-_238861830 0.483 NM_022817
PER2
period homolog 2 (Drosophila)
chr16_+_2746363 0.481


chr20_+_56903595 0.480 GNAS
GNAS complex locus
chr1_+_93070202 0.475 RPL5
ribosomal protein L5
chr14_+_22305570 0.475 NM_005015
OXA1L
oxidase (cytochrome c) assembly 1-like
chr6_-_128263868 0.475 NM_001010923
NM_001164685
THEMIS

thymocyte selection associated

chr12_+_68150332 0.474 NM_001042555
NM_006654
FRS2

fibroblast growth factor receptor substrate 2

chr1_-_94779727 0.473 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr2_+_148495043 0.473 NM_018328
MBD5
methyl-CpG binding domain protein 5
chr1_+_93070186 0.472 RPL5
ribosomal protein L5
chr1_-_31251315 0.472 PUM1
pumilio homolog 1 (Drosophila)
chr3_+_113180517 0.471 NM_018394
ABHD10
abhydrolase domain containing 10
chr20_+_52525538 0.471 NM_018431
DOK5
docking protein 5
chr13_+_96797290 0.470


chr3_-_79899748 0.470 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr14_-_22515725 0.469 JUB
jub, ajuba homolog (Xenopus laevis)
chr5_+_38881716 0.468 NM_001168355
OSMR
oncostatin M receptor
chr12_-_42231990 0.468 NM_025003
ADAMTS20
ADAM metallopeptidase with thrombospondin type 1 motif, 20
chr16_+_18903009 0.468 NM_001160364
TMC7
transmembrane channel-like 7
chr2_-_241903787 0.467 HDLBP
high density lipoprotein binding protein
chr10_+_96152262 0.467 TBC1D12
TBC1 domain family, member 12
chr5_+_36912656 0.466 NIPBL
Nipped-B homolog (Drosophila)
chr7_+_29200636 0.466 NM_004067
CHN2
chimerin (chimaerin) 2
chr3_+_106568430 0.465 ALCAM
activated leukocyte cell adhesion molecule
chr20_+_32045541 0.465 RALY
RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse))
chr14_+_75688025 0.465 C14orf118
chromosome 14 open reading frame 118
chr2_+_241903395 0.464 NM_001008491
NM_006155
SEPT2

septin 2

chr10_+_5126556 0.464 NM_003739
AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr1_+_93070120 0.462 NM_000969
RPL5
ribosomal protein L5
chr20_+_42273013 0.461 LOC100505783
hypothetical LOC100505783
chr2_-_241903925 0.457 NM_005336
HDLBP
high density lipoprotein binding protein
chr3_-_192531018 0.457 NM_198152
UTS2D
urotensin 2 domain containing
chr14_+_36200867 0.456 PAX9
paired box 9
chr2_+_241904024 0.456 SEPT2
septin 2
chr2_+_171493870 0.456 NM_015530
GORASP2
golgi reassembly stacking protein 2, 55kDa
chr14_-_49848538 0.455 NM_024884
L2HGDH
L-2-hydroxyglutarate dehydrogenase
chr20_+_32045347 0.455 RALY
RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse))
chr5_-_38881636 0.454


chr2_+_186311599 0.453 NM_173651
FSIP2
fibrous sheath interacting protein 2
chr1_+_70459686 0.451 SRSF11
serine/arginine-rich splicing factor 11
chr6_+_110406890 0.450 NM_005284
GPR6
G protein-coupled receptor 6
chr5_+_38881719 0.450 NM_003999
OSMR
oncostatin M receptor
chr14_+_36200815 0.449 PAX9
paired box 9

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.48 6.77e-03 GO:0042060 wound healing
1.37 1.53e-02 GO:0016265 death
1.21 1.65e-02 GO:0048519 negative regulation of biological process
1.37 1.69e-02 GO:0008219 cell death
1.22 2.17e-02 GO:0048523 negative regulation of cellular process
1.32 2.72e-02 GO:0010646 regulation of cell communication
1.14 3.20e-02 GO:0044260 cellular macromolecule metabolic process
1.40 3.25e-02 GO:0006915 apoptosis
1.22 3.46e-02 GO:0048869 cellular developmental process
1.06 3.95e-02 GO:0009987 cellular process
1.35 4.12e-02 GO:0009611 response to wounding
1.39 4.95e-02 GO:0012501 programmed cell death

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.08 1.52e-06 GO:0044424 intracellular part
1.08 2.57e-06 GO:0005622 intracellular
1.10 6.09e-05 GO:0005737 cytoplasm
1.08 2.39e-03 GO:0043231 intracellular membrane-bounded organelle
1.07 3.11e-03 GO:0043226 organelle
1.08 3.18e-03 GO:0043227 membrane-bounded organelle
1.07 3.33e-03 GO:0043229 intracellular organelle
1.79 6.21e-03 GO:0031252 cell leading edge
2.26 2.92e-02 GO:0031256 leading edge membrane
1.03 2.97e-02 GO:0005623 cell
1.03 3.68e-02 GO:0044464 cell part
1.10 4.49e-02 GO:0044444 cytoplasmic part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.15 1.36e-09 GO:0005515 protein binding
1.07 2.20e-05 GO:0005488 binding