Motif ID: NKX6-1,2.p2

Z-value: 1.259


Transcription factors associated with NKX6-1,2.p2:

Gene SymbolEntrez IDGene Name
NKX6-1 4825 NK6 homeobox 1
NKX6-2 84504 NK6 homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX6-2chr10_-_134449467-0.312.5e-01Click!
NKX6-1chr4_-_856384100.214.4e-01Click!


Activity profile for motif NKX6-1,2.p2.

activity profile for motif NKX6-1,2.p2


Sorted Z-values histogram for motif NKX6-1,2.p2

Sorted Z-values for motif NKX6-1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX6-1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_21375258 2.631 NM_000605
IFNA2
interferon, alpha 2
chr5_-_58331515 2.270 NM_001197223
PDE4D
phosphodiesterase 4D, cAMP-specific
chr3_-_79899748 1.861 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr14_+_62740878 1.638 NM_020663
RHOJ
ras homolog gene family, member J
chr13_+_23042722 1.516 NM_148957
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr6_-_128263868 1.452 NM_001010923
NM_001164685
THEMIS

thymocyte selection associated

chr4_+_70928718 1.204 NM_000200
HTN3
histatin 3
chr8_-_82769761 1.181 NM_001010893
SLC10A5
solute carrier family 10 (sodium/bile acid cotransporter family), member 5
chr15_+_34720097 1.147 NM_032499
C15orf41
chromosome 15 open reading frame 41
chr20_+_23293020 1.115 NM_022482
GZF1
GDNF-inducible zinc finger protein 1
chr2_+_191222077 1.051 NM_005966
NAB1
NGFI-A binding protein 1 (EGR1 binding protein 1)
chr12_+_32546243 1.044 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr3_+_130014957 1.033 RAB7A
RAB7A, member RAS oncogene family
chr3_-_121065112 0.995


chr1_+_245835478 0.991 NM_001001914
OR2G3
olfactory receptor, family 2, subfamily G, member 3
chr6_-_66346417 0.988 NM_198283
EYS
eyes shut homolog (Drosophila)
chr14_-_63076155 0.975 PPP2R5E
protein phosphatase 2, regulatory subunit B', epsilon isoform
chr20_+_11846536 0.966 NM_014962
BTBD3
BTB (POZ) domain containing 3
chr12_-_131816604 0.958 ANKLE2
ankyrin repeat and LEM domain containing 2
chr6_+_118976134 0.956 NM_002667
PLN
phospholamban
chr2_+_228064531 0.920 AGFG1
ArfGAP with FG repeats 1
chr20_-_51633042 0.920 NM_006526
ZNF217
zinc finger protein 217
chr12_-_44919818 0.913 SLC38A1
solute carrier family 38, member 1
chr8_-_13018123 0.890 NM_001164271
DLC1
deleted in liver cancer 1
chr11_-_5964790 0.889 NM_001005173
OR52L1
olfactory receptor, family 52, subfamily L, member 1
chr6_+_88026338 0.878 ZNF292
zinc finger protein 292
chr6_-_138935359 0.850 NM_020464
NHSL1
NHS-like 1
chr15_+_47502666 0.842 NM_002009
FGF7
fibroblast growth factor 7
chr1_+_185064654 0.839 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr2_+_108751033 0.832 RANBP2
RAN binding protein 2
chr18_-_49944986 0.822 MBD2
methyl-CpG binding domain protein 2
chr17_+_55269974 0.820


chr21_+_30937053 0.810 NM_001128077
KRTAP20-3
keratin associated protein 20-3
chr2_-_178495768 0.803 NM_001077358
PDE11A
phosphodiesterase 11A
chr2_-_144711375 0.795 NM_024659
GTDC1
glycosyltransferase-like domain containing 1
chr6_-_138862271 0.769 NM_001144060
NHSL1
NHS-like 1
chr8_-_66863841 0.768 NM_002603
PDE7A
phosphodiesterase 7A
chr6_+_153113624 0.764 NM_003381
NM_194435
VIP

vasoactive intestinal peptide

chr9_-_28709302 0.751 NM_152570
LINGO2
leucine rich repeat and Ig domain containing 2
chr8_+_11225904 0.738 NM_054028
AMAC1L2
acyl-malonyl condensing enzyme 1-like 2
chr12_-_11106159 0.737 NM_176887
TAS2R46
taste receptor, type 2, member 46
chr11_+_101488380 0.735 NM_001195045
YAP1
Yes-associated protein 1
chr1_+_78858675 0.731 NM_006820
IFI44L
interferon-induced protein 44-like
chr8_+_79591074 0.706 PKIA
protein kinase (cAMP-dependent, catalytic) inhibitor alpha
chr9_+_87745876 0.705 NM_024635
NAA35
N(alpha)-acetyltransferase 35, NatC auxiliary subunit
chr1_-_152394215 0.699 NM_001159484
NM_207308
NUP210L

nucleoporin 210kDa-like

chr4_-_170314382 0.696 SH3RF1
SH3 domain containing ring finger 1
chr3_+_150065732 0.689 NM_001870
CPA3
carboxypeptidase A3 (mast cell)
chr14_-_60185659 0.679 NM_005982
SIX1
SIX homeobox 1
chr6_-_50039776 0.671 NM_001037499
DEFB114
defensin, beta 114
chr20_-_1298493 0.646 FKBP1A
FK506 binding protein 1A, 12kDa
chr8_-_131483395 0.643 NM_018482
ASAP1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
chr8_+_104900591 0.643 NM_014677
RIMS2
regulating synaptic membrane exocytosis 2
chr21_-_30614477 0.629 NM_203405
KRTAP26-1
keratin associated protein 26-1
chr7_+_132588359 0.627 NM_001037126
NM_021807
EXOC4

exocyst complex component 4

chr11_+_103412517 0.623 NM_001001711
DDI1
DNA-damage inducible 1 homolog 1 (S. cerevisiae)
chr12_-_10464308 0.619 NM_002261
NM_007333
KLRC3

killer cell lectin-like receptor subfamily C, member 3

chr12_-_11041740 0.614 NM_176889
TAS2R20
taste receptor, type 2, member 20
chr17_+_63367052 0.607 BPTF
bromodomain PHD finger transcription factor
chr10_+_28918672 0.596 WAC
WW domain containing adaptor with coiled-coil
chr6_-_138862273 0.596


chr10_-_98311813 0.595 TM9SF3
transmembrane 9 superfamily member 3
chr4_-_23500706 0.593 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr9_-_106407728 0.589 NM_001004481
OR13C2
olfactory receptor, family 13, subfamily C, member 2
chr18_+_30544193 0.588 NM_001198941
NM_032978
DTNA

dystrobrevin, alpha

chr13_+_49487390 0.585 NM_173605
NM_199464
TRIM13
KCNRG

tripartite motif containing 13
potassium channel regulator

chr10_+_31650069 0.577 NM_001128128
NM_001174094
ZEB1

zinc finger E-box binding homeobox 1

chr11_-_36576352 0.567 NM_000536
RAG2
recombination activating gene 2
chr16_+_68238460 0.563 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr16_-_3783475 0.561 CREBBP
CREB binding protein
chr17_-_36403910 0.559 NM_033185
KRTAP3-3
keratin associated protein 3-3
chr2_+_223433919 0.555 NM_004457
NM_203372
ACSL3

acyl-CoA synthetase long-chain family member 3

chr4_-_152368492 0.555 SH3D19
SH3 domain containing 19
chr22_+_29696662 0.554


chr4_-_2200755 0.552 NM_181808
POLN
polymerase (DNA directed) nu
chr3_+_51550635 0.550 NM_015106
RAD54L2
RAD54-like 2 (S. cerevisiae)
chr7_-_22518200 0.550 EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr12_+_9871343 0.544 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr20_+_16676997 0.537 NM_020157
OTOR
otoraplin
chr1_-_115071195 0.532 CSDE1
cold shock domain containing E1, RNA-binding
chr13_+_51496679 0.531 NM_021645
ALG11
UTP14C
asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast)
UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)
chr17_+_58625086 0.530 TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr8_+_24354387 0.527 NM_003817
ADAM7
ADAM metallopeptidase domain 7
chrX_-_102973762 0.525 NM_016370
RAB9B
RAB9B, member RAS oncogene family
chr6_+_132901119 0.524 NM_175057
TAAR9
trace amine associated receptor 9 (gene/pseudogene)
chr12_-_44644216 0.517


chr2_+_108360798 0.514 NM_006588
SULT1C4
sulfotransferase family, cytosolic, 1C, member 4
chr10_+_50557689 0.513 NM_001042427
NM_182554
C10orf53

chromosome 10 open reading frame 53

chr3_-_194579207 0.511 NM_198505
ATP13A5
ATPase type 13A5
chr11_-_7684516 0.506 NM_198185
OVCH2
ovochymase 2 (gene/pseudogene)
chr11_+_93916653 0.496 NM_002033
PIWIL4
FUT4
piwi-like 4 (Drosophila)
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chr13_+_96726415 0.494 MBNL2
muscleblind-like 2 (Drosophila)
chr14_-_94669547 0.488 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr1_+_144188375 0.488 NM_153713
LIX1L
Lix1 homolog (mouse)-like
chr6_-_132064233 0.487 NM_030908
OR2A4
olfactory receptor, family 2, subfamily A, member 4
chr3_-_25654659 0.482 TOP2B
topoisomerase (DNA) II beta 180kDa
chr13_-_45323757 0.480 NM_198849
SIAH3
seven in absentia homolog 3 (Drosophila)
chr15_+_32048380 0.476 NM_012125
CHRM5
cholinergic receptor, muscarinic 5
chr10_+_124135574 0.474 NM_001195608
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr11_-_57964221 0.474 NM_001004733
OR5B12
olfactory receptor, family 5, subfamily B, member 12
chr4_-_17415918 0.470 DCAF16
DDB1 and CUL4 associated factor 16
chr1_-_246857051 0.470 NM_001001964
OR2T11
olfactory receptor, family 2, subfamily T, member 11
chr19_-_53912025 0.468 NM_182574
MAMSTR
MEF2 activating motif and SAP domain containing transcriptional regulator
chr1_+_115198977 0.468 NM_003176
SYCP1
synaptonemal complex protein 1
chr14_-_23727826 0.467 IPO4
importin 4
chr5_+_166644420 0.467 NM_001122679
ODZ2
odz, odd Oz/ten-m homolog 2 (Drosophila)
chr2_-_183095308 0.458 NM_005019
NM_001003683
PDE1A

phosphodiesterase 1A, calmodulin-dependent

chr8_+_79590890 0.453 NM_006823
NM_181839
PKIA

protein kinase (cAMP-dependent, catalytic) inhibitor alpha

chr3_+_99592199 0.452 NM_001005516
OR5K3
olfactory receptor, family 5, subfamily K, member 3
chr4_+_53975597 0.452 FIP1L1
FIP1 like 1 (S. cerevisiae)
chr4_-_87593306 0.440 NM_002753
MAPK10
mitogen-activated protein kinase 10
chr17_-_36376663 0.438 NM_213656
KRT39
keratin 39
chrX_-_34060348 0.434 NM_203408
FAM47A
family with sequence similarity 47, member A
chr14_-_23727850 0.430 NM_024658
IPO4
importin 4
chr19_+_60962318 0.428 NM_001145014
RFPL4A
ret finger protein-like 4A
chr8_-_91164100 0.427 NM_004929
CALB1
calbindin 1, 28kDa
chr11_-_55815113 0.427 NM_001005199
OR8H1
olfactory receptor, family 8, subfamily H, member 1
chr13_-_102517196 0.426 NM_000452
SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter family), member 2
chr2_-_65447267 0.425 SPRED2
sprouty-related, EVH1 domain containing 2
chr4_-_146315341 0.414 NM_017493
OTUD4
OTU domain containing 4
chr3_+_175641340 0.412 NAALADL2
N-acetylated alpha-linked acidic dipeptidase-like 2
chrX_+_102727068 0.405 NM_001006935
NM_001006937
NM_024863
TCEAL4


transcription elongation factor A (SII)-like 4


chr18_+_59705918 0.404 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr15_-_74091817 0.403 NM_138573
NRG4
neuregulin 4
chr4_-_90978469 0.403 NM_001146055
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr2_+_183316574 0.401 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr2_-_165768798 0.401 NM_001081676
NM_001081677
NM_006922
SCN3A


sodium channel, voltage-gated, type III, alpha subunit


chr9_+_115303527 0.401 NM_130795
RGS3
regulator of G-protein signaling 3
chr2_-_65447370 0.394 NM_001128210
SPRED2
sprouty-related, EVH1 domain containing 2
chr6_-_87861492 0.393 NM_000735
CGA
glycoprotein hormones, alpha polypeptide
chr4_-_70760381 0.392 NM_005420
SULT1E1
sulfotransferase family 1E, estrogen-preferring, member 1
chr5_+_161427225 0.391 NM_000816
NM_198903
NM_198904
GABRG2


gamma-aminobutyric acid (GABA) A receptor, gamma 2


chr2_+_118288724 0.391 NM_006773
DDX18
DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
chr2_-_210876560 0.389 NM_079422
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr9_-_21340885 0.387 NM_021002
IFNA6
interferon, alpha 6
chr2_+_118288754 0.385 DDX18
DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
chr2_-_121964373 0.385 CLASP1
cytoplasmic linker associated protein 1
chr2_-_210726539 0.384 C2orf67
chromosome 2 open reading frame 67
chr3_+_45902999 0.384 NM_006641
NM_031200
CCR9

chemokine (C-C motif) receptor 9

chr2_+_118288753 0.383 DDX18
DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
chr10_-_69661860 0.383 NM_145178
ATOH7
atonal homolog 7 (Drosophila)
chr8_-_52884456 0.383 NM_144651
PXDNL
peroxidasin homolog (Drosophila)-like
chr8_-_82522175 0.381 NM_002677
PMP2
peripheral myelin protein 2
chr17_+_36228869 0.381 NM_001195387
NM_145274
NM_001195386
TMEM99


transmembrane protein 99


chr15_-_74941339 0.379 NM_001145923
SCAPER
S-phase cyclin A-associated protein in the ER
chr11_-_27637771 0.375 NM_001143816
NM_170735
BDNF

brain-derived neurotrophic factor

chr11_-_57883117 0.374 NM_001005489
OR5B17
olfactory receptor, family 5, subfamily B, member 17
chr9_-_72673753 0.371 NM_001007470
NM_020952
NM_024971
NM_206944
NM_206945
NM_206946
NM_206947
NM_206948
TRPM3







transient receptor potential cation channel, subfamily M, member 3







chr7_+_72034735 0.370 POM121
POM121 membrane glycoprotein
chr12_+_63090008 0.366 XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chr1_+_84402962 0.366 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr20_+_56455866 0.366 VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr7_-_122627235 0.364 NM_022444
SLC13A1
solute carrier family 13 (sodium/sulfate symporters), member 1
chr10_+_86121526 0.360 FAM190B
family with sequence similarity 190, member B
chr2_+_224530361 0.360 NM_022915
MRPL44
mitochondrial ribosomal protein L44
chr7_-_26198673 0.359 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr12_-_53664722 0.356 NM_001136030
KIAA0748
KIAA0748
chr3_-_197726587 0.355 NM_001077657
C3orf43
chromosome 3 open reading frame 43
chr14_-_56342097 0.355 NM_172337
OTX2
orthodenticle homeobox 2
chr9_-_13240313 0.348 NM_003829
MPDZ
multiple PDZ domain protein
chrX_-_138114100 0.348 FGF13
fibroblast growth factor 13
chr2_-_37397669 0.347 NM_005813
PRKD3
protein kinase D3
chr4_+_22608252 0.346


chr6_+_53991672 0.345 NM_138569
C6orf142
chromosome 6 open reading frame 142
chr7_-_107667728 0.344 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr21_-_30786145 0.342 NM_181609
KRTAP19-3
keratin associated protein 19-3
chr3_-_166397142 0.341 NM_014926
SLITRK3
SLIT and NTRK-like family, member 3
chr21_-_31332665 0.341 NM_001099219
KRTAP19-8
keratin associated protein 19-8
chr3_+_99484421 0.338 NM_001005482
OR5H2
olfactory receptor, family 5, subfamily H, member 2
chr2_+_137464931 0.337 NM_001080427
THSD7B
thrombospondin, type I, domain containing 7B
chr19_+_12036513 0.335 NM_001136501
ZNF844
zinc finger protein 844
chr20_-_18425811 0.334 NM_006606
RBBP9
retinoblastoma binding protein 9
chr5_-_43326922 0.334 HMGCS1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr18_-_29882555 0.333 NM_001198549
NOL4
nucleolar protein 4
chr14_+_59628381 0.333 NM_022495
C14orf135
chromosome 14 open reading frame 135
chr1_+_85300580 0.333 NM_145172
WDR63
WD repeat domain 63
chr12_-_11075272 0.332 NM_176885
TAS2R31
taste receptor, type 2, member 31
chrX_-_76824726 0.330 ATRX
alpha thalassemia/mental retardation syndrome X-linked
chr12_+_49155798 0.330 LARP4
La ribonucleoprotein domain family, member 4
chr11_+_55799604 0.330 NM_001004745
OR5T1
olfactory receptor, family 5, subfamily T, member 1
chr9_-_106420305 0.329 NM_001001956
OR13C9
olfactory receptor, family 13, subfamily C, member 9
chr7_+_142053693 0.327 NM_001190487
MTRNR2L6
MT-RNR2-like 6
chr3_+_12367993 0.327 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chr8_+_133060353 0.326 EFR3A
EFR3 homolog A (S. cerevisiae)
chr1_+_103898844 0.325 NM_020978
AMY2B
amylase, alpha 2B (pancreatic)
chr21_-_30781537 0.325 NM_181608
KRTAP19-2
keratin associated protein 19-2
chr1_-_245988330 0.325 NM_012353
OR1C1
olfactory receptor, family 1, subfamily C, member 1
chr2_+_37282516 0.324 LOC100505876
hypothetical LOC100505876
chr17_+_36636404 0.322 NM_031961
KRTAP9-2
keratin associated protein 9-2
chr5_-_150707281 0.320 NM_181776
SLC36A2
solute carrier family 36 (proton/amino acid symporter), member 2
chr3_+_39346200 0.319 NM_005201
CCR8
chemokine (C-C motif) receptor 8
chr4_+_71283383 0.318 NM_006685
SMR3B
submaxillary gland androgen regulated protein 3B
chr3_-_51912376 0.316 NM_152397
IQCF1
IQ motif containing F1
chr3_+_63859114 0.316 NM_001177387
ATXN7
ataxin 7
chr2_-_37150876 0.316 HEATR5B
HEAT repeat containing 5B
chr10_-_33264491 0.314 NM_033668
ITGB1
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
chr14_-_19867372 0.314 NM_182852
NM_182851
CCNB1IP1

cyclin B1 interacting protein 1, E3 ubiquitin protein ligase

chr1_+_61642287 0.313 NFIA
nuclear factor I/A
chr5_+_161207517 0.313 NM_001127644
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chrX_+_85404626 0.313 NM_001139515
DACH2
dachshund homolog 2 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.39 1.50e-07 GO:0007606 sensory perception of chemical stimulus
2.30 1.47e-05 GO:0007608 sensory perception of smell
1.83 9.63e-05 GO:0007600 sensory perception
1.52 4.04e-04 GO:0003008 system process
1.57 1.12e-03 GO:0050877 neurological system process
1.19 2.39e-02 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.20 4.45e-02 GO:0045111 intermediate filament cytoskeleton

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.32 4.65e-06 GO:0004984 olfactory receptor activity
1.72 4.26e-04 GO:0004930 G-protein coupled receptor activity
1.49 7.53e-03 GO:0004888 transmembrane receptor activity