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Motif ID: NKX6-1,2.p2

Z-value: 1.259

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr9_-_21375258	2.631	NM_000605	IFNA2	interferon, alpha 2
chr5_-_58331515	2.270	NM_001197223	PDE4D	phosphodiesterase 4D, cAMP-specific
chr3_-_79899748	1.861	NM_002941	ROBO1	roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr14_+_62740878	1.638	NM_020663	RHOJ	ras homolog gene family, member J
chr13_+_23042722	1.516	NM_148957	TNFRSF19	tumor necrosis factor receptor superfamily, member 19
chr6_-_128263868	1.452	NM_001010923 NM_001164685	THEMIS	thymocyte selection associated
chr4_+_70928718	1.204	NM_000200	HTN3	histatin 3
chr8_-_82769761	1.181	NM_001010893	SLC10A5	solute carrier family 10 (sodium/bile acid cotransporter family), member 5
chr15_+_34720097	1.147	NM_032499	C15orf41	chromosome 15 open reading frame 41
chr20_+_23293020	1.115	NM_022482	GZF1	GDNF-inducible zinc finger protein 1
chr2_+_191222077	1.051	NM_005966	NAB1	NGFI-A binding protein 1 (EGR1 binding protein 1)
chr12_+_32546243	1.044	NM_139241	FGD4	FYVE, RhoGEF and PH domain containing 4
chr3_+_130014957	1.033		RAB7A	RAB7A, member RAS oncogene family
chr3_-_121065112	0.995
chr1_+_245835478	0.991	NM_001001914	OR2G3	olfactory receptor, family 2, subfamily G, member 3
chr6_-_66346417	0.988	NM_198283	EYS	eyes shut homolog (Drosophila)
chr14_-_63076155	0.975		PPP2R5E	protein phosphatase 2, regulatory subunit B', epsilon isoform
chr20_+_11846536	0.966	NM_014962	BTBD3	BTB (POZ) domain containing 3
chr12_-_131816604	0.958		ANKLE2	ankyrin repeat and LEM domain containing 2
chr6_+_118976134	0.956	NM_002667	PLN	phospholamban
chr2_+_228064531	0.920		AGFG1	ArfGAP with FG repeats 1
chr20_-_51633042	0.920	NM_006526	ZNF217	zinc finger protein 217
chr12_-_44919818	0.913		SLC38A1	solute carrier family 38, member 1
chr8_-_13018123	0.890	NM_001164271	DLC1	deleted in liver cancer 1
chr11_-_5964790	0.889	NM_001005173	OR52L1	olfactory receptor, family 52, subfamily L, member 1
chr6_+_88026338	0.878		ZNF292	zinc finger protein 292
chr6_-_138935359	0.850	NM_020464	NHSL1	NHS-like 1
chr15_+_47502666	0.842	NM_002009	FGF7	fibroblast growth factor 7
chr1_+_185064654	0.839	NM_024420	PLA2G4A	phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr2_+_108751033	0.832		RANBP2	RAN binding protein 2
chr18_-_49944986	0.822		MBD2	methyl-CpG binding domain protein 2
chr17_+_55269974	0.820
chr21_+_30937053	0.810	NM_001128077	KRTAP20-3	keratin associated protein 20-3
chr2_-_178495768	0.803	NM_001077358	PDE11A	phosphodiesterase 11A
chr2_-_144711375	0.795	NM_024659	GTDC1	glycosyltransferase-like domain containing 1
chr6_-_138862271	0.769	NM_001144060	NHSL1	NHS-like 1
chr8_-_66863841	0.768	NM_002603	PDE7A	phosphodiesterase 7A
chr6_+_153113624	0.764	NM_003381 NM_194435	VIP	vasoactive intestinal peptide
chr9_-_28709302	0.751	NM_152570	LINGO2	leucine rich repeat and Ig domain containing 2
chr8_+_11225904	0.738	NM_054028	AMAC1L2	acyl-malonyl condensing enzyme 1-like 2
chr12_-_11106159	0.737	NM_176887	TAS2R46	taste receptor, type 2, member 46
chr11_+_101488380	0.735	NM_001195045	YAP1	Yes-associated protein 1
chr1_+_78858675	0.731	NM_006820	IFI44L	interferon-induced protein 44-like
chr8_+_79591074	0.706		PKIA	protein kinase (cAMP-dependent, catalytic) inhibitor alpha
chr9_+_87745876	0.705	NM_024635	NAA35	N(alpha)-acetyltransferase 35, NatC auxiliary subunit
chr1_-_152394215	0.699	NM_001159484 NM_207308	NUP210L	nucleoporin 210kDa-like
chr4_-_170314382	0.696		SH3RF1	SH3 domain containing ring finger 1
chr3_+_150065732	0.689	NM_001870	CPA3	carboxypeptidase A3 (mast cell)
chr14_-_60185659	0.679	NM_005982	SIX1	SIX homeobox 1
chr6_-_50039776	0.671	NM_001037499	DEFB114	defensin, beta 114
chr20_-_1298493	0.646		FKBP1A	FK506 binding protein 1A, 12kDa
chr8_-_131483395	0.643	NM_018482	ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
chr8_+_104900591	0.643	NM_014677	RIMS2	regulating synaptic membrane exocytosis 2
chr21_-_30614477	0.629	NM_203405	KRTAP26-1	keratin associated protein 26-1
chr7_+_132588359	0.627	NM_001037126 NM_021807	EXOC4	exocyst complex component 4
chr11_+_103412517	0.623	NM_001001711	DDI1	DNA-damage inducible 1 homolog 1 (S. cerevisiae)
chr12_-_10464308	0.619	NM_002261 NM_007333	KLRC3	killer cell lectin-like receptor subfamily C, member 3
chr12_-_11041740	0.614	NM_176889	TAS2R20	taste receptor, type 2, member 20
chr17_+_63367052	0.607		BPTF	bromodomain PHD finger transcription factor
chr10_+_28918672	0.596		WAC	WW domain containing adaptor with coiled-coil
chr6_-_138862273	0.596
chr10_-_98311813	0.595		TM9SF3	transmembrane 9 superfamily member 3
chr4_-_23500706	0.593	NM_013261	PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr9_-_106407728	0.589	NM_001004481	OR13C2	olfactory receptor, family 13, subfamily C, member 2
chr18_+_30544193	0.588	NM_001198941 NM_032978	DTNA	dystrobrevin, alpha
chr13_+_49487390	0.585	NM_173605 NM_199464	TRIM13 KCNRG	tripartite motif containing 13 potassium channel regulator
chr10_+_31650069	0.577	NM_001128128 NM_001174094	ZEB1	zinc finger E-box binding homeobox 1
chr11_-_36576352	0.567	NM_000536	RAG2	recombination activating gene 2
chr16_+_68238460	0.563		NFAT5	nuclear factor of activated T-cells 5, tonicity-responsive
chr16_-_3783475	0.561		CREBBP	CREB binding protein
chr17_-_36403910	0.559	NM_033185	KRTAP3-3	keratin associated protein 3-3
chr2_+_223433919	0.555	NM_004457 NM_203372	ACSL3	acyl-CoA synthetase long-chain family member 3
chr4_-_152368492	0.555		SH3D19	SH3 domain containing 19
chr22_+_29696662	0.554
chr4_-_2200755	0.552	NM_181808	POLN	polymerase (DNA directed) nu
chr3_+_51550635	0.550	NM_015106	RAD54L2	RAD54-like 2 (S. cerevisiae)
chr7_-_22518200	0.550		EEF1A1	eukaryotic translation elongation factor 1 alpha 1
chr12_+_9871343	0.544	NM_016523	KLRF1	killer cell lectin-like receptor subfamily F, member 1
chr20_+_16676997	0.537	NM_020157	OTOR	otoraplin
chr1_-_115071195	0.532		CSDE1	cold shock domain containing E1, RNA-binding
chr13_+_51496679	0.531	NM_021645	ALG11 UTP14C	asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast) UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)
chr17_+_58625086	0.530		TANC2	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr8_+_24354387	0.527	NM_003817	ADAM7	ADAM metallopeptidase domain 7
chrX_-_102973762	0.525	NM_016370	RAB9B	RAB9B, member RAS oncogene family
chr6_+_132901119	0.524	NM_175057	TAAR9	trace amine associated receptor 9 (gene/pseudogene)
chr12_-_44644216	0.517
chr2_+_108360798	0.514	NM_006588	SULT1C4	sulfotransferase family, cytosolic, 1C, member 4
chr10_+_50557689	0.513	NM_001042427 NM_182554	C10orf53	chromosome 10 open reading frame 53
chr3_-_194579207	0.511	NM_198505	ATP13A5	ATPase type 13A5
chr11_-_7684516	0.506	NM_198185	OVCH2	ovochymase 2 (gene/pseudogene)
chr11_+_93916653	0.496	NM_002033	PIWIL4 FUT4	piwi-like 4 (Drosophila) fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chr13_+_96726415	0.494		MBNL2	muscleblind-like 2 (Drosophila)
chr14_-_94669547	0.488	NM_001195573	DICER1	dicer 1, ribonuclease type III
chr1_+_144188375	0.488	NM_153713	LIX1L	Lix1 homolog (mouse)-like
chr6_-_132064233	0.487	NM_030908	OR2A4	olfactory receptor, family 2, subfamily A, member 4
chr3_-_25654659	0.482		TOP2B	topoisomerase (DNA) II beta 180kDa
chr13_-_45323757	0.480	NM_198849	SIAH3	seven in absentia homolog 3 (Drosophila)
chr15_+_32048380	0.476	NM_012125	CHRM5	cholinergic receptor, muscarinic 5
chr10_+_124135574	0.474	NM_001195608	PLEKHA1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr11_-_57964221	0.474	NM_001004733	OR5B12	olfactory receptor, family 5, subfamily B, member 12
chr4_-_17415918	0.470		DCAF16	DDB1 and CUL4 associated factor 16
chr1_-_246857051	0.470	NM_001001964	OR2T11	olfactory receptor, family 2, subfamily T, member 11
chr19_-_53912025	0.468	NM_182574	MAMSTR	MEF2 activating motif and SAP domain containing transcriptional regulator
chr1_+_115198977	0.468	NM_003176	SYCP1	synaptonemal complex protein 1
chr14_-_23727826	0.467		IPO4	importin 4
chr5_+_166644420	0.467	NM_001122679	ODZ2	odz, odd Oz/ten-m homolog 2 (Drosophila)
chr2_-_183095308	0.458	NM_005019 NM_001003683	PDE1A	phosphodiesterase 1A, calmodulin-dependent
chr8_+_79590890	0.453	NM_006823 NM_181839	PKIA	protein kinase (cAMP-dependent, catalytic) inhibitor alpha
chr3_+_99592199	0.452	NM_001005516	OR5K3	olfactory receptor, family 5, subfamily K, member 3
chr4_+_53975597	0.452		FIP1L1	FIP1 like 1 (S. cerevisiae)
chr4_-_87593306	0.440	NM_002753	MAPK10	mitogen-activated protein kinase 10
chr17_-_36376663	0.438	NM_213656	KRT39	keratin 39
chrX_-_34060348	0.434	NM_203408	FAM47A	family with sequence similarity 47, member A
chr14_-_23727850	0.430	NM_024658	IPO4	importin 4
chr19_+_60962318	0.428	NM_001145014	RFPL4A	ret finger protein-like 4A
chr8_-_91164100	0.427	NM_004929	CALB1	calbindin 1, 28kDa
chr11_-_55815113	0.427	NM_001005199	OR8H1	olfactory receptor, family 8, subfamily H, member 1
chr13_-_102517196	0.426	NM_000452	SLC10A2	solute carrier family 10 (sodium/bile acid cotransporter family), member 2
chr2_-_65447267	0.425		SPRED2	sprouty-related, EVH1 domain containing 2
chr4_-_146315341	0.414	NM_017493	OTUD4	OTU domain containing 4
chr3_+_175641340	0.412		NAALADL2	N-acetylated alpha-linked acidic dipeptidase-like 2
chrX_+_102727068	0.405	NM_001006935 NM_001006937 NM_024863	TCEAL4	transcription elongation factor A (SII)-like 4
chr18_+_59705918	0.404	NM_001143818 NM_002575	SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2
chr15_-_74091817	0.403	NM_138573	NRG4	neuregulin 4
chr4_-_90978469	0.403	NM_001146055	SNCA	synuclein, alpha (non A4 component of amyloid precursor)
chr2_+_183316574	0.401		DNAJC10	DnaJ (Hsp40) homolog, subfamily C, member 10
chr2_-_165768798	0.401	NM_001081676 NM_001081677 NM_006922	SCN3A	sodium channel, voltage-gated, type III, alpha subunit
chr9_+_115303527	0.401	NM_130795	RGS3	regulator of G-protein signaling 3
chr2_-_65447370	0.394	NM_001128210	SPRED2	sprouty-related, EVH1 domain containing 2
chr6_-_87861492	0.393	NM_000735	CGA	glycoprotein hormones, alpha polypeptide
chr4_-_70760381	0.392	NM_005420	SULT1E1	sulfotransferase family 1E, estrogen-preferring, member 1
chr5_+_161427225	0.391	NM_000816 NM_198903 NM_198904	GABRG2	gamma-aminobutyric acid (GABA) A receptor, gamma 2
chr2_+_118288724	0.391	NM_006773	DDX18	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
chr2_-_210876560	0.389	NM_079422	MYL1	myosin, light chain 1, alkali; skeletal, fast
chr9_-_21340885	0.387	NM_021002	IFNA6	interferon, alpha 6
chr2_+_118288754	0.385		DDX18	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
chr2_-_121964373	0.385		CLASP1	cytoplasmic linker associated protein 1
chr2_-_210726539	0.384		C2orf67	chromosome 2 open reading frame 67
chr3_+_45902999	0.384	NM_006641 NM_031200	CCR9	chemokine (C-C motif) receptor 9
chr2_+_118288753	0.383		DDX18	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
chr10_-_69661860	0.383	NM_145178	ATOH7	atonal homolog 7 (Drosophila)
chr8_-_52884456	0.383	NM_144651	PXDNL	peroxidasin homolog (Drosophila)-like
chr8_-_82522175	0.381	NM_002677	PMP2	peripheral myelin protein 2
chr17_+_36228869	0.381	NM_001195387 NM_145274 NM_001195386	TMEM99	transmembrane protein 99
chr15_-_74941339	0.379	NM_001145923	SCAPER	S-phase cyclin A-associated protein in the ER
chr11_-_27637771	0.375	NM_001143816 NM_170735	BDNF	brain-derived neurotrophic factor
chr11_-_57883117	0.374	NM_001005489	OR5B17	olfactory receptor, family 5, subfamily B, member 17
chr9_-_72673753	0.371	NM_001007470 NM_020952 NM_024971 NM_206944 NM_206945 NM_206946 NM_206947 NM_206948	TRPM3	transient receptor potential cation channel, subfamily M, member 3
chr7_+_72034735	0.370		POM121	POM121 membrane glycoprotein
chr12_+_63090008	0.366		XPOT	exportin, tRNA (nuclear export receptor for tRNAs)
chr1_+_84402962	0.366		PRKACB	protein kinase, cAMP-dependent, catalytic, beta
chr20_+_56455866	0.366		VAPB	VAMP (vesicle-associated membrane protein)-associated protein B and C
chr7_-_122627235	0.364	NM_022444	SLC13A1	solute carrier family 13 (sodium/sulfate symporters), member 1
chr10_+_86121526	0.360		FAM190B	family with sequence similarity 190, member B
chr2_+_224530361	0.360	NM_022915	MRPL44	mitochondrial ribosomal protein L44
chr7_-_26198673	0.359		HNRNPA2B1	heterogeneous nuclear ribonucleoprotein A2/B1
chr12_-_53664722	0.356	NM_001136030	KIAA0748	KIAA0748
chr3_-_197726587	0.355	NM_001077657	C3orf43	chromosome 3 open reading frame 43
chr14_-_56342097	0.355	NM_172337	OTX2	orthodenticle homeobox 2
chr9_-_13240313	0.348	NM_003829	MPDZ	multiple PDZ domain protein
chrX_-_138114100	0.348		FGF13	fibroblast growth factor 13
chr2_-_37397669	0.347	NM_005813	PRKD3	protein kinase D3
chr4_+_22608252	0.346
chr6_+_53991672	0.345	NM_138569	C6orf142	chromosome 6 open reading frame 142
chr7_-_107667728	0.344	NM_001037132	NRCAM	neuronal cell adhesion molecule
chr21_-_30786145	0.342	NM_181609	KRTAP19-3	keratin associated protein 19-3
chr3_-_166397142	0.341	NM_014926	SLITRK3	SLIT and NTRK-like family, member 3
chr21_-_31332665	0.341	NM_001099219	KRTAP19-8	keratin associated protein 19-8
chr3_+_99484421	0.338	NM_001005482	OR5H2	olfactory receptor, family 5, subfamily H, member 2
chr2_+_137464931	0.337	NM_001080427	THSD7B	thrombospondin, type I, domain containing 7B
chr19_+_12036513	0.335	NM_001136501	ZNF844	zinc finger protein 844
chr20_-_18425811	0.334	NM_006606	RBBP9	retinoblastoma binding protein 9
chr5_-_43326922	0.334		HMGCS1	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr18_-_29882555	0.333	NM_001198549	NOL4	nucleolar protein 4
chr14_+_59628381	0.333	NM_022495	C14orf135	chromosome 14 open reading frame 135
chr1_+_85300580	0.333	NM_145172	WDR63	WD repeat domain 63
chr12_-_11075272	0.332	NM_176885	TAS2R31	taste receptor, type 2, member 31
chrX_-_76824726	0.330		ATRX	alpha thalassemia/mental retardation syndrome X-linked
chr12_+_49155798	0.330		LARP4	La ribonucleoprotein domain family, member 4
chr11_+_55799604	0.330	NM_001004745	OR5T1	olfactory receptor, family 5, subfamily T, member 1
chr9_-_106420305	0.329	NM_001001956	OR13C9	olfactory receptor, family 13, subfamily C, member 9
chr7_+_142053693	0.327	NM_001190487	MTRNR2L6	MT-RNR2-like 6
chr3_+_12367993	0.327	NM_015869	PPARG	peroxisome proliferator-activated receptor gamma
chr8_+_133060353	0.326		EFR3A	EFR3 homolog A (S. cerevisiae)
chr1_+_103898844	0.325	NM_020978	AMY2B	amylase, alpha 2B (pancreatic)
chr21_-_30781537	0.325	NM_181608	KRTAP19-2	keratin associated protein 19-2
chr1_-_245988330	0.325	NM_012353	OR1C1	olfactory receptor, family 1, subfamily C, member 1
chr2_+_37282516	0.324		LOC100505876	hypothetical LOC100505876
chr17_+_36636404	0.322	NM_031961	KRTAP9-2	keratin associated protein 9-2
chr5_-_150707281	0.320	NM_181776	SLC36A2	solute carrier family 36 (proton/amino acid symporter), member 2
chr3_+_39346200	0.319	NM_005201	CCR8	chemokine (C-C motif) receptor 8
chr4_+_71283383	0.318	NM_006685	SMR3B	submaxillary gland androgen regulated protein 3B
chr3_-_51912376	0.316	NM_152397	IQCF1	IQ motif containing F1
chr3_+_63859114	0.316	NM_001177387	ATXN7	ataxin 7
chr2_-_37150876	0.316		HEATR5B	HEAT repeat containing 5B
chr10_-_33264491	0.314	NM_033668	ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
chr14_-_19867372	0.314	NM_182852 NM_182851	CCNB1IP1	cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
chr1_+_61642287	0.313		NFIA	nuclear factor I/A
chr5_+_161207517	0.313	NM_001127644	GABRA1	gamma-aminobutyric acid (GABA) A receptor, alpha 1
chrX_+_85404626	0.313	NM_001139515	DACH2	dachshund homolog 2 (Drosophila)

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
2.39	1.50e-07	GO:0007606	sensory perception of chemical stimulus
2.30	1.47e-05	GO:0007608	sensory perception of smell
1.83	9.63e-05	GO:0007600	sensory perception
1.52	4.04e-04	GO:0003008	system process
1.57	1.12e-03	GO:0050877	neurological system process
1.19	2.39e-02	GO:0050896	response to stimulus

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
2.20	4.45e-02	GO:0045111	intermediate filament cytoskeleton

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
2.32	4.65e-06	GO:0004984	olfactory receptor activity
1.72	4.26e-04	GO:0004930	G-protein coupled receptor activity
1.49	7.53e-03	GO:0004888	transmembrane receptor activity