• All motifs sorted by activity significance
• All samples sorted alphabetically
• Mean activities

• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
• Download the whole report

Motif ID: PAX2.p2

Z-value: 1.204

---

Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr18_+_9126742	2.110	NM_001083625 NM_015208	ANKRD12	ankyrin repeat domain 12
chr6_+_127629677	1.607	NM_030963	RNF146	ring finger protein 146
chr5_-_133734616	1.454		CDKL3	cyclin-dependent kinase-like 3
chr5_+_133734768	1.405	NM_003337	UBE2B	ubiquitin-conjugating enzyme E2B (RAD6 homolog)
chr15_+_41597097	0.901	NM_002373	MAP1A	microtubule-associated protein 1A
chr17_+_55052060	0.894		CLTC	clathrin, heavy chain (Hc)
chr17_+_55051818	0.890	NM_004859	CLTC	clathrin, heavy chain (Hc)
chr2_+_46779827	0.890	NM_144949	SOCS5	suppressor of cytokine signaling 5
chr6_+_89847019	0.878	NM_006813	PNRC1	proline-rich nuclear receptor coactivator 1
chr6_+_87921980	0.876	NM_015021	ZNF292	zinc finger protein 292
chr6_+_89847183	0.875		PNRC1	proline-rich nuclear receptor coactivator 1
chr18_+_30875297	0.869	NM_014268	MAPRE2	microtubule-associated protein, RP/EB family, member 2
chr15_+_41871809	0.845		SERF2-C15ORF63 SERF2	SERF2-C15orf63 read-through transcript small EDRK-rich factor 2
chr20_+_46971618	0.843	NM_006420	ARFGEF2	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
chr17_+_55052046	0.838		CLTC	clathrin, heavy chain (Hc)
chr3_+_19963534	0.819	NM_004162	RAB5A	RAB5A, member RAS oncogene family
chr15_+_41871768	0.816	NM_001018108	SERF2	small EDRK-rich factor 2
chr1_-_152459697	0.795	NM_001098616 NM_015449 NM_138740	C1orf43	chromosome 1 open reading frame 43
chr2_+_46779553	0.791	NM_014011	SOCS5	suppressor of cytokine signaling 5
chr17_+_55052065	0.785		CLTC	clathrin, heavy chain (Hc)
chr11_+_120399966	0.779	NM_001130047 NM_152715	TBCEL	tubulin folding cofactor E-like
chr9_-_99724559	0.762	NM_016481	C9orf156	chromosome 9 open reading frame 156
chr6_+_89848229	0.761		PNRC1	proline-rich nuclear receptor coactivator 1
chr1_-_152459506	0.747		C1orf43	chromosome 1 open reading frame 43
chr1_-_152459667	0.717		C1orf43	chromosome 1 open reading frame 43
chr19_-_10625449	0.707		LOC147727	hypothetical LOC147727
chr4_+_144325533	0.696		USP38	ubiquitin specific peptidase 38
chr17_+_33761234	0.686	NM_014598	SOCS7	suppressor of cytokine signaling 7
chr9_+_116389918	0.684		ATP6V1G1	ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
chr17_+_55052185	0.680
chr4_+_144654005	0.678	NM_003601	SMARCA5	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
chr4_+_144325502	0.639	NM_032557	USP38	ubiquitin specific peptidase 38
chr14_-_64040072	0.632	NM_006977	ZBTB25	zinc finger and BTB domain containing 25
chr9_+_116389814	0.628	NM_004888	ATP6V1G1	ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
chr19_+_10625896	0.620	NM_001137673 NM_004516 NM_012218 NM_017620 NM_153464	ILF3	interleukin enhancer binding factor 3, 90kDa
chr9_+_70978970	0.617		TJP2	tight junction protein 2 (zona occludens 2)
chr12_+_15926681	0.609		STRAP	serine/threonine kinase receptor associated protein
chr9_+_70978790	0.604	NM_001170630 NM_004817 NM_201629	TJP2	tight junction protein 2 (zona occludens 2)
chr5_+_60663842	0.598	NM_020928	ZSWIM6	zinc finger, SWIM-type containing 6
chr12_+_15926554	0.595	NM_007178	STRAP	serine/threonine kinase receptor associated protein
chr2_+_105320440	0.573	NM_024093	C2orf49	chromosome 2 open reading frame 49
chr1_-_11788666	0.573	NM_005957	MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)
chr2_+_42249896	0.573	NM_001145076 NM_019063	EML4	echinoderm microtubule associated protein like 4
chr19_+_10625987	0.559		ILF3	interleukin enhancer binding factor 3, 90kDa
chr5_+_133735004	0.559		UBE2B	ubiquitin-conjugating enzyme E2B (RAD6 homolog)
chr5_-_141372721	0.542	NM_005471	GNPDA1	glucosamine-6-phosphate deaminase 1
chr12_+_104025675	0.537		KIAA1033	KIAA1033
chr10_+_102662675	0.533		FAM178A	family with sequence similarity 178, member A
chr12_+_15926743	0.517		STRAP	serine/threonine kinase receptor associated protein
chr1_+_11788793	0.516	NM_001286 NM_021735 NM_021736 NM_021737	CLCN6	chloride channel 6
chr3_+_19963865	0.512		RAB5A	RAB5A, member RAS oncogene family
chr2_+_105320247	0.507		C2orf49	chromosome 2 open reading frame 49
chr11_+_64948860	0.506		NEAT1	nuclear paraspeckle assembly transcript 1 (non-protein coding)
chr10_+_128583984	0.503	NM_001380	DOCK1	dedicator of cytokinesis 1
chr1_+_11788827	0.502		CLCN6	chloride channel 6
chr12_+_104025667	0.496		KIAA1033	KIAA1033
chr5_+_14493905	0.487		TRIO	triple functional domain (PTPRF interacting)
chr6_+_64403685	0.484		PHF3	PHD finger protein 3
chr6_+_64403631	0.482		PHF3	PHD finger protein 3
chr2_+_228045053	0.482		AGFG1	ArfGAP with FG repeats 1
chr12_-_104025540	0.480		LOC414300	hypothetical LOC414300
chr1_+_152459918	0.480	NM_014847	UBAP2L	ubiquitin associated protein 2-like
chr1_+_11788889	0.477		CLCN6	chloride channel 6
chr2_+_28828332	0.465		PPP1CB	protein phosphatase 1, catalytic subunit, beta isozyme
chr12_+_104025686	0.462
chr2_+_228045121	0.459	NM_001135187 NM_001135188 NM_001135189 NM_004504	AGFG1	ArfGAP with FG repeats 1
chr12_+_104025578	0.459	NM_015275	KIAA1033	KIAA1033
chr6_+_64403936	0.458		PHF3	PHD finger protein 3
chr1_-_11788550	0.458		MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)
chr5_+_65476418	0.449	NM_139168	SREK1	splicing regulatory glutamine/lysine-rich protein 1
chr17_+_36642240	0.447	NM_031962	KRTAP9-9 KRTAP9-3	keratin associated protein 9-9 keratin associated protein 9-3
chr15_-_71712711	0.439	NM_001161363 NM_001161364 NM_012428 NM_017455	NPTN	neuroplastin
chr6_+_139497933	0.438	NM_016217	HECA	headcase homolog (Drosophila)
chr6_+_160310118	0.434	NM_000876	IGF2R	insulin-like growth factor 2 receptor
chr5_+_41940216	0.426	NM_175921	C5orf51	chromosome 5 open reading frame 51
chr12_-_88573949	0.425	NM_001001323 NM_001682	ATP2B1	ATPase, Ca++ transporting, plasma membrane 1
chr6_+_64403668	0.424		PHF3	PHD finger protein 3
chr4_+_120029426	0.423	NM_001128933 NM_001128934 NM_133477	SYNPO2	synaptopodin 2
chr5_+_67622242	0.422	NM_181504	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr7_+_98084531	0.421	NM_002523	NPTX2	neuronal pentraxin II
chr16_+_24458349	0.421	NM_006910 NM_018703 NM_032626	RBBP6	retinoblastoma binding protein 6
chr10_+_23768203	0.421	NM_001145373	OTUD1	OTU domain containing 1
chr16_+_66676833	0.419		NFATC3	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
chr18_+_75967902	0.417	NM_014913	ADNP2	ADNP homeobox 2
chrX_+_77246430	0.414		PGK1	phosphoglycerate kinase 1
chr16_+_66676851	0.412	NM_004555 NM_173163 NM_173164 NM_173165	NFATC3	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
chr4_-_39199527	0.412		UGDH	UDP-glucose 6-dehydrogenase
chr10_+_111959978	0.409	NM_001008541	MXI1	MAX interactor 1
chr10_+_29006425	0.406	NM_012342	BAMBI	BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)
chr2_+_135392857	0.405	NM_001241 NM_058241	CCNT2	cyclin T2
chr2_+_27659396	0.405	NM_032434	ZNF512	zinc finger protein 512
chr15_+_39739864	0.403	NM_001080541 NM_001164273	MGA	MAX gene associated
chr12_+_52696908	0.402	NM_014620 NM_153693	HOXC4 HOXC6	homeobox C4 homeobox C6
chr12_+_54396118	0.402		BLOC1S1	biogenesis of lysosomal organelles complex-1, subunit 1
chr9_+_27514311	0.400	NM_020124	IFNK	interferon, kappa
chr7_-_95789204	0.400	NM_001160210 NM_014251	SLC25A13	solute carrier family 25, member 13 (citrin)
chr3_+_12573513	0.397	NM_014160	MKRN2	makorin ring finger protein 2
chr19_+_10626106	0.397		ILF3	interleukin enhancer binding factor 3, 90kDa
chr14_+_22860511	0.397		PABPN1	poly(A) binding protein, nuclear 1
chr9_-_14769530	0.396	NM_001177704	FREM1	FRAS1 related extracellular matrix 1
chr10_+_97794139	0.394
chr16_-_4837266	0.392	NM_032569	GLYR1	glyoxylate reductase 1 homolog (Arabidopsis)
chr1_+_36462625	0.391		THRAP3	thyroid hormone receptor associated protein 3
chr4_+_56414565	0.389	NM_001024924 NM_018261 NM_178237	EXOC1	exocyst complex component 1
chr2_+_62787534	0.384	NM_001142614	EHBP1	EH domain binding protein 1
chr14_+_64040979	0.384	NM_001123329 NM_014950	ZBTB1	zinc finger and BTB domain containing 1
chr12_+_22669275	0.384	NM_001039481 NM_018638	ETNK1	ethanolamine kinase 1
chr22_+_38903825	0.383	NM_001162501 NM_015088	TNRC6B	trinucleotide repeat containing 6B
chr3_-_121550767	0.380	NM_001099678	LRRC58	leucine rich repeat containing 58
chr10_+_69314347	0.379	NM_012238	SIRT1	sirtuin 1
chr14_-_23968570	0.378	NM_001039771	CBLN3	cerebellin 3 precursor
chr12_+_54396086	0.378	NM_001487	BLOC1S1	biogenesis of lysosomal organelles complex-1, subunit 1
chr15_+_39739933	0.374		MGA	MAX gene associated
chr1_+_78243181	0.374	NM_007034	DNAJB4	DnaJ (Hsp40) homolog, subfamily B, member 4
chr5_+_110102639	0.373	NM_138773	SLC25A46	solute carrier family 25, member 46
chr20_+_37024383	0.373	NM_001190809 NM_021931	DHX35	DEAH (Asp-Glu-Ala-His) box polypeptide 35
chr12_+_54396099	0.371		BLOC1S1-RDH5 BLOC1S1	BLOC1S1-RDH5 read-through transcript biogenesis of lysosomal organelles complex-1, subunit 1
chr12_+_79634820	0.370	NM_005593	MYF5	myogenic factor 5
chr12_+_22669352	0.364		ETNK1	ethanolamine kinase 1
chr17_+_45617676	0.364
chr5_+_156819782	0.362		NIPAL4	NIPA-like domain containing 4
chr1_+_40399642	0.360		RLF	rearranged L-myc fusion
chr1_-_171286634	0.359	NM_005092	TNFSF18	tumor necrosis factor (ligand) superfamily, member 18
chr2_+_177785667	0.358	NM_194247	HNRNPA3P1 HNRNPA3	heterogeneous nuclear ribonucleoprotein A3 pseudogene 1 heterogeneous nuclear ribonucleoprotein A3
chr18_+_58533597	0.357	NM_194449	PHLPP1	PH domain and leucine rich repeat protein phosphatase 1
chr6_+_116939500	0.351	NM_153711	FAM26E	family with sequence similarity 26, member E
chr5_+_110102607	0.350		SLC25A46	solute carrier family 25, member 46
chr1_+_40399618	0.348	NM_012421	RLF	rearranged L-myc fusion
chr11_+_64946820	0.347		NEAT1	nuclear paraspeckle assembly transcript 1 (non-protein coding)
chr13_+_48582389	0.342	NM_014923	FNDC3A	fibronectin type III domain containing 3A
chr10_+_29006530	0.342		BAMBI	BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)
chr11_-_11600118	0.341	NM_198516	GALNTL4	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 4
chr2_+_233270286	0.331		GIGYF2	GRB10 interacting GYF protein 2
chr3_+_23962518	0.331	NM_001145425	NR1D2	nuclear receptor subfamily 1, group D, member 2
chr16_+_51722285	0.329		CHD9	chromodomain helicase DNA binding protein 9
chr18_+_75968133	0.329		ADNP2	ADNP homeobox 2
chr1_+_152460381	0.328		UBAP2L	ubiquitin associated protein 2-like
chr1_+_26671488	0.327	NM_005517	HMGN2	high-mobility group nucleosomal binding domain 2
chr1_+_100276238	0.326		HIAT1	hippocampus abundant transcript 1
chr12_+_49185011	0.325	NM_173602	DIP2B	DIP2 disco-interacting protein 2 homolog B (Drosophila)
chr2_-_21081694	0.325		APOB	apolipoprotein B (including Ag(x) antigen)
chr6_+_7053183	0.323		RREB1	ras responsive element binding protein 1
chr6_+_64340388	0.323		PTP4A1	protein tyrosine phosphatase type IVA, member 1
chr12_+_49185035	0.323		DIP2B	DIP2 disco-interacting protein 2 homolog B (Drosophila)
chr16_+_55523526	0.318		HERPUD1	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr2_+_177965617	0.317	NM_003659	AGPS	alkylglycerone phosphate synthase
chrX_+_77246409	0.317		PGK1	phosphoglycerate kinase 1
chr4_+_106287391	0.316	NM_001127208 NM_017628	TET2	tet oncogene family member 2
chr1_+_52294554	0.316		BTF3L4	basic transcription factor 3-like 4
chr1_+_100276242	0.314	NM_033055	HIAT1	hippocampus abundant transcript 1
chr8_+_98725670	0.314		MTDH	metadherin
chr10_+_102662315	0.311	NM_001136123 NM_018121	FAM178A	family with sequence similarity 178, member A
chr11_+_12652427	0.311	NM_021961	TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr12_+_68923477	0.307		CNOT2	CCR4-NOT transcription complex, subunit 2
chr1_+_159550789	0.307	NM_001035511 NM_001035512 NM_001035513 NM_003001	SDHC	succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
chr12_+_63958949	0.307	NM_001193461	MSRB3	methionine sulfoxide reductase B3
chr2_+_233270275	0.305		GIGYF2	GRB10 interacting GYF protein 2
chr12_+_70434927	0.304		RAB21	RAB21, member RAS oncogene family
chr9_+_131937163	0.304		GPR107	G protein-coupled receptor 107
chr3_+_180348818	0.304	NM_006218	PIK3CA	phosphoinositide-3-kinase, catalytic, alpha polypeptide
chr12_-_56432375	0.303		CDK4	cyclin-dependent kinase 4
chr2_+_177965734	0.303		AGPS	alkylglycerone phosphate synthase
chr12_-_56432377	0.303		CDK4	cyclin-dependent kinase 4
chr8_+_109525010	0.302	NM_014673	TTC35	tetratricopeptide repeat domain 35
chr22_-_27993823	0.302	NM_012265	RHBDD3	rhomboid domain containing 3
chr15_-_68781662	0.302	NM_001008224	UACA	uveal autoantigen with coiled-coil domains and ankyrin repeats
chrX_+_77246368	0.302		PGK1	phosphoglycerate kinase 1
chr1_+_36462583	0.301	NM_005119	THRAP3	thyroid hormone receptor associated protein 3
chr5_+_10406802	0.301	NM_005885	MARCH6	membrane-associated ring finger (C3HC4) 6
chr6_-_119712596	0.300	NM_005907	MAN1A1	mannosidase, alpha, class 1A, member 1
chr2_+_28828112	0.300	NM_206876 NM_002709	PPP1CB	protein phosphatase 1, catalytic subunit, beta isozyme
chr22_+_27993997	0.299	NM_001163285 NM_001163286 NM_001163287 NM_005243 NM_013986	EWSR1	Ewing sarcoma breakpoint region 1
chr15_-_71712605	0.299		NPTN	neuroplastin
chr2_+_64604940	0.298	NM_001002243 NM_017657 NM_203437	AFTPH	aftiphilin
chr20_+_57948803	0.298	NM_001190827 NM_022106	C20orf177	chromosome 20 open reading frame 177
chr1_+_52294563	0.298		BTF3L4	basic transcription factor 3-like 4
chr17_+_25467948	0.297	NM_032141	CCDC55	coiled-coil domain containing 55
chr3_+_114948550	0.296	NM_001690	ATP6V1A	ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr12_+_99185289	0.296		SCYL2	SCY1-like 2 (S. cerevisiae)
chr2_+_233270241	0.296	NM_001103146 NM_001103147 NM_001103148 NM_015575	GIGYF2	GRB10 interacting GYF protein 2
chr2_+_135392879	0.295		CCNT2	cyclin T2
chr15_+_39363442	0.294		LOC729082	hypothetical LOC729082
chr6_+_44463265	0.293	NM_001253	CDC5L	CDC5 cell division cycle 5-like (S. pombe)
chr8_+_109525050	0.292		TTC35	tetratricopeptide repeat domain 35
chr16_+_55523248	0.292	NM_001010989 NM_001010990 NM_014685	HERPUD1	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr17_+_7289086	0.291	NM_000747	CHRNB1	cholinergic receptor, nicotinic, beta 1 (muscle)
chr19_+_8415594	0.291		HNRNPM	heterogeneous nuclear ribonucleoprotein M
chr12_+_51686504	0.289		EIF4B	eukaryotic translation initiation factor 4B
chr15_+_43667050	0.288		PLDN	pallidin homolog (mouse)
chr8_+_67201684	0.288	NM_033058 NM_184085 NM_184086 NM_184087	TRIM55	tripartite motif containing 55
chr3_+_140545528	0.287	NM_020191	MRPS22	mitochondrial ribosomal protein S22
chr12_-_75477692	0.285	NM_001003712 NM_020841	OSBPL8	oxysterol binding protein-like 8
chr10_-_99436889	0.285	NM_021732	AVPI1	arginine vasopressin-induced 1
chr2_-_85683268	0.283	NM_001031738	TMEM150A	transmembrane protein 150A
chr11_+_105453501	0.283	NM_015423	AASDHPPT	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
chr1_-_155374756	0.283		ETV3	ets variant 3
chr6_-_151754337	0.282	NM_020861	ZBTB2	zinc finger and BTB domain containing 2
chr17_+_40580466	0.281	NM_006460	HEXIM1	hexamethylene bis-acetamide inducible 1
chr6_-_84994032	0.281	NM_014895	KIAA1009	KIAA1009
chr21_-_37367259	0.280	NM_153682	PIGP	phosphatidylinositol glycan anchor biosynthesis, class P

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.27	9.40e-04	GO:0090304	nucleic acid metabolic process
1.08	1.07e-03	GO:0009987	cellular process
1.47	1.84e-03	GO:0046907	intracellular transport
1.16	3.00e-03	GO:0043170	macromolecule metabolic process
1.34	4.13e-03	GO:0033036	macromolecule localization
1.17	5.08e-03	GO:0044260	cellular macromolecule metabolic process
1.22	5.17e-03	GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.29	6.08e-03	GO:0016070	RNA metabolic process
1.27	1.49e-02	GO:0010467	gene expression
1.32	2.89e-02	GO:0051641	cellular localization
1.39	2.96e-02	GO:0008219	cell death
1.90	3.61e-02	GO:0006913	nucleocytoplasmic transport
1.39	3.95e-02	GO:0016265	death
1.61	4.59e-02	GO:0044419	interspecies interaction between organisms

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.11	6.49e-11	GO:0044424	intracellular part
1.10	3.99e-10	GO:0005622	intracellular
1.14	5.93e-09	GO:0005737	cytoplasm
1.11	3.29e-07	GO:0043229	intracellular organelle
1.11	4.66e-07	GO:0043226	organelle
1.11	6.37e-06	GO:0043231	intracellular membrane-bounded organelle
1.11	8.82e-06	GO:0043227	membrane-bounded organelle
1.16	3.21e-05	GO:0044422	organelle part
1.15	6.54e-05	GO:0044446	intracellular organelle part
1.15	1.54e-04	GO:0005634	nucleus
1.20	2.62e-04	GO:0032991	macromolecular complex
1.26	3.01e-04	GO:0044428	nuclear part
1.34	5.25e-04	GO:0005654	nucleoplasm
1.21	8.90e-04	GO:0043234	protein complex
1.13	1.29e-03	GO:0044444	cytoplasmic part
1.24	5.00e-03	GO:0005829	cytosol
1.23	3.12e-02	GO:0031981	nuclear lumen
1.20	3.68e-02	GO:0043233	organelle lumen

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.17	9.12e-11	GO:0005515	protein binding
1.66	8.44e-04	GO:0000988	protein binding transcription factor activity
1.66	8.44e-04	GO:0000989	transcription factor binding transcription factor activity
1.07	8.86e-04	GO:0005488	binding
1.65	1.43e-03	GO:0003712	transcription cofactor activity
1.77	1.25e-02	GO:0003713	transcription coactivator activity
2.59	2.61e-02	GO:0004879	ligand-dependent nuclear receptor activity
2.61	3.73e-02	GO:0003707	steroid hormone receptor activity