Motif ID: PAX2.p2

Z-value: 1.204


Transcription factors associated with PAX2.p2:

Gene SymbolEntrez IDGene Name
PAX2 5076 paired box 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PAX2chr10_+_102495327-0.712.0e-03Click!


Activity profile for motif PAX2.p2.

activity profile for motif PAX2.p2


Sorted Z-values histogram for motif PAX2.p2

Sorted Z-values for motif PAX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PAX2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_+_9126742 2.110 NM_001083625
NM_015208
ANKRD12

ankyrin repeat domain 12

chr6_+_127629677 1.607 NM_030963
RNF146
ring finger protein 146
chr5_-_133734616 1.454 CDKL3
cyclin-dependent kinase-like 3
chr5_+_133734768 1.405 NM_003337
UBE2B
ubiquitin-conjugating enzyme E2B (RAD6 homolog)
chr15_+_41597097 0.901 NM_002373
MAP1A
microtubule-associated protein 1A
chr17_+_55052060 0.894 CLTC
clathrin, heavy chain (Hc)
chr17_+_55051818 0.890 NM_004859
CLTC
clathrin, heavy chain (Hc)
chr2_+_46779827 0.890 NM_144949
SOCS5
suppressor of cytokine signaling 5
chr6_+_89847019 0.878 NM_006813
PNRC1
proline-rich nuclear receptor coactivator 1
chr6_+_87921980 0.876 NM_015021
ZNF292
zinc finger protein 292
chr6_+_89847183 0.875 PNRC1
proline-rich nuclear receptor coactivator 1
chr18_+_30875297 0.869 NM_014268
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr15_+_41871809 0.845 SERF2-C15ORF63
SERF2
SERF2-C15orf63 read-through transcript
small EDRK-rich factor 2
chr20_+_46971618 0.843 NM_006420
ARFGEF2
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
chr17_+_55052046 0.838 CLTC
clathrin, heavy chain (Hc)
chr3_+_19963534 0.819 NM_004162
RAB5A
RAB5A, member RAS oncogene family
chr15_+_41871768 0.816 NM_001018108
SERF2
small EDRK-rich factor 2
chr1_-_152459697 0.795 NM_001098616
NM_015449
NM_138740
C1orf43


chromosome 1 open reading frame 43


chr2_+_46779553 0.791 NM_014011
SOCS5
suppressor of cytokine signaling 5
chr17_+_55052065 0.785 CLTC
clathrin, heavy chain (Hc)
chr11_+_120399966 0.779 NM_001130047
NM_152715
TBCEL

tubulin folding cofactor E-like

chr9_-_99724559 0.762 NM_016481
C9orf156
chromosome 9 open reading frame 156
chr6_+_89848229 0.761 PNRC1
proline-rich nuclear receptor coactivator 1
chr1_-_152459506 0.747 C1orf43
chromosome 1 open reading frame 43
chr1_-_152459667 0.717 C1orf43
chromosome 1 open reading frame 43
chr19_-_10625449 0.707 LOC147727
hypothetical LOC147727
chr4_+_144325533 0.696 USP38
ubiquitin specific peptidase 38
chr17_+_33761234 0.686 NM_014598
SOCS7
suppressor of cytokine signaling 7
chr9_+_116389918 0.684 ATP6V1G1
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
chr17_+_55052185 0.680


chr4_+_144654005 0.678 NM_003601
SMARCA5
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
chr4_+_144325502 0.639 NM_032557
USP38
ubiquitin specific peptidase 38
chr14_-_64040072 0.632 NM_006977
ZBTB25
zinc finger and BTB domain containing 25
chr9_+_116389814 0.628 NM_004888
ATP6V1G1
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
chr19_+_10625896 0.620 NM_001137673
NM_004516
NM_012218
NM_017620
NM_153464
ILF3




interleukin enhancer binding factor 3, 90kDa




chr9_+_70978970 0.617 TJP2
tight junction protein 2 (zona occludens 2)
chr12_+_15926681 0.609 STRAP
serine/threonine kinase receptor associated protein
chr9_+_70978790 0.604 NM_001170630
NM_004817
NM_201629
TJP2


tight junction protein 2 (zona occludens 2)


chr5_+_60663842 0.598 NM_020928
ZSWIM6
zinc finger, SWIM-type containing 6
chr12_+_15926554 0.595 NM_007178
STRAP
serine/threonine kinase receptor associated protein
chr2_+_105320440 0.573 NM_024093
C2orf49
chromosome 2 open reading frame 49
chr1_-_11788666 0.573 NM_005957
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr2_+_42249896 0.573 NM_001145076
NM_019063
EML4

echinoderm microtubule associated protein like 4

chr19_+_10625987 0.559 ILF3
interleukin enhancer binding factor 3, 90kDa
chr5_+_133735004 0.559 UBE2B
ubiquitin-conjugating enzyme E2B (RAD6 homolog)
chr5_-_141372721 0.542 NM_005471
GNPDA1
glucosamine-6-phosphate deaminase 1
chr12_+_104025675 0.537 KIAA1033
KIAA1033
chr10_+_102662675 0.533 FAM178A
family with sequence similarity 178, member A
chr12_+_15926743 0.517 STRAP
serine/threonine kinase receptor associated protein
chr1_+_11788793 0.516 NM_001286
NM_021735
NM_021736
NM_021737
CLCN6



chloride channel 6



chr3_+_19963865 0.512 RAB5A
RAB5A, member RAS oncogene family
chr2_+_105320247 0.507 C2orf49
chromosome 2 open reading frame 49
chr11_+_64948860 0.506 NEAT1
nuclear paraspeckle assembly transcript 1 (non-protein coding)
chr10_+_128583984 0.503 NM_001380
DOCK1
dedicator of cytokinesis 1
chr1_+_11788827 0.502 CLCN6
chloride channel 6
chr12_+_104025667 0.496 KIAA1033
KIAA1033
chr5_+_14493905 0.487 TRIO
triple functional domain (PTPRF interacting)
chr6_+_64403685 0.484 PHF3
PHD finger protein 3
chr6_+_64403631 0.482 PHF3
PHD finger protein 3
chr2_+_228045053 0.482 AGFG1
ArfGAP with FG repeats 1
chr12_-_104025540 0.480 LOC414300
hypothetical LOC414300
chr1_+_152459918 0.480 NM_014847
UBAP2L
ubiquitin associated protein 2-like
chr1_+_11788889 0.477 CLCN6
chloride channel 6
chr2_+_28828332 0.465 PPP1CB
protein phosphatase 1, catalytic subunit, beta isozyme
chr12_+_104025686 0.462


chr2_+_228045121 0.459 NM_001135187
NM_001135188
NM_001135189
NM_004504
AGFG1



ArfGAP with FG repeats 1



chr12_+_104025578 0.459 NM_015275
KIAA1033
KIAA1033
chr6_+_64403936 0.458 PHF3
PHD finger protein 3
chr1_-_11788550 0.458 MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr5_+_65476418 0.449 NM_139168
SREK1
splicing regulatory glutamine/lysine-rich protein 1
chr17_+_36642240 0.447 NM_031962
KRTAP9-9
KRTAP9-3
keratin associated protein 9-9
keratin associated protein 9-3
chr15_-_71712711 0.439 NM_001161363
NM_001161364
NM_012428
NM_017455
NPTN



neuroplastin



chr6_+_139497933 0.438 NM_016217
HECA
headcase homolog (Drosophila)
chr6_+_160310118 0.434 NM_000876
IGF2R
insulin-like growth factor 2 receptor
chr5_+_41940216 0.426 NM_175921
C5orf51
chromosome 5 open reading frame 51
chr12_-_88573949 0.425 NM_001001323
NM_001682
ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

chr6_+_64403668 0.424 PHF3
PHD finger protein 3
chr4_+_120029426 0.423 NM_001128933
NM_001128934
NM_133477
SYNPO2


synaptopodin 2


chr5_+_67622242 0.422 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr7_+_98084531 0.421 NM_002523
NPTX2
neuronal pentraxin II
chr16_+_24458349 0.421 NM_006910
NM_018703
NM_032626
RBBP6


retinoblastoma binding protein 6


chr10_+_23768203 0.421 NM_001145373
OTUD1
OTU domain containing 1
chr16_+_66676833 0.419 NFATC3
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
chr18_+_75967902 0.417 NM_014913
ADNP2
ADNP homeobox 2
chrX_+_77246430 0.414 PGK1
phosphoglycerate kinase 1
chr16_+_66676851 0.412 NM_004555
NM_173163
NM_173164
NM_173165
NFATC3



nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3



chr4_-_39199527 0.412 UGDH
UDP-glucose 6-dehydrogenase
chr10_+_111959978 0.409 NM_001008541
MXI1
MAX interactor 1
chr10_+_29006425 0.406 NM_012342
BAMBI
BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)
chr2_+_135392857 0.405 NM_001241
NM_058241
CCNT2

cyclin T2

chr2_+_27659396 0.405 NM_032434
ZNF512
zinc finger protein 512
chr15_+_39739864 0.403 NM_001080541
NM_001164273
MGA

MAX gene associated

chr12_+_52696908 0.402 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr12_+_54396118 0.402 BLOC1S1
biogenesis of lysosomal organelles complex-1, subunit 1
chr9_+_27514311 0.400 NM_020124
IFNK
interferon, kappa
chr7_-_95789204 0.400 NM_001160210
NM_014251
SLC25A13

solute carrier family 25, member 13 (citrin)

chr3_+_12573513 0.397 NM_014160
MKRN2
makorin ring finger protein 2
chr19_+_10626106 0.397 ILF3
interleukin enhancer binding factor 3, 90kDa
chr14_+_22860511 0.397 PABPN1
poly(A) binding protein, nuclear 1
chr9_-_14769530 0.396 NM_001177704
FREM1
FRAS1 related extracellular matrix 1
chr10_+_97794139 0.394


chr16_-_4837266 0.392 NM_032569
GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr1_+_36462625 0.391 THRAP3
thyroid hormone receptor associated protein 3
chr4_+_56414565 0.389 NM_001024924
NM_018261
NM_178237
EXOC1


exocyst complex component 1


chr2_+_62787534 0.384 NM_001142614
EHBP1
EH domain binding protein 1
chr14_+_64040979 0.384 NM_001123329
NM_014950
ZBTB1

zinc finger and BTB domain containing 1

chr12_+_22669275 0.384 NM_001039481
NM_018638
ETNK1

ethanolamine kinase 1

chr22_+_38903825 0.383 NM_001162501
NM_015088
TNRC6B

trinucleotide repeat containing 6B

chr3_-_121550767 0.380 NM_001099678
LRRC58
leucine rich repeat containing 58
chr10_+_69314347 0.379 NM_012238
SIRT1
sirtuin 1
chr14_-_23968570 0.378 NM_001039771
CBLN3
cerebellin 3 precursor
chr12_+_54396086 0.378 NM_001487
BLOC1S1
biogenesis of lysosomal organelles complex-1, subunit 1
chr15_+_39739933 0.374 MGA
MAX gene associated
chr1_+_78243181 0.374 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr5_+_110102639 0.373 NM_138773
SLC25A46
solute carrier family 25, member 46
chr20_+_37024383 0.373 NM_001190809
NM_021931
DHX35

DEAH (Asp-Glu-Ala-His) box polypeptide 35

chr12_+_54396099 0.371 BLOC1S1-RDH5
BLOC1S1
BLOC1S1-RDH5 read-through transcript
biogenesis of lysosomal organelles complex-1, subunit 1
chr12_+_79634820 0.370 NM_005593
MYF5
myogenic factor 5
chr12_+_22669352 0.364 ETNK1
ethanolamine kinase 1
chr17_+_45617676 0.364


chr5_+_156819782 0.362 NIPAL4
NIPA-like domain containing 4
chr1_+_40399642 0.360 RLF
rearranged L-myc fusion
chr1_-_171286634 0.359 NM_005092
TNFSF18
tumor necrosis factor (ligand) superfamily, member 18
chr2_+_177785667 0.358 NM_194247
HNRNPA3P1
HNRNPA3
heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
heterogeneous nuclear ribonucleoprotein A3
chr18_+_58533597 0.357 NM_194449
PHLPP1
PH domain and leucine rich repeat protein phosphatase 1
chr6_+_116939500 0.351 NM_153711
FAM26E
family with sequence similarity 26, member E
chr5_+_110102607 0.350 SLC25A46
solute carrier family 25, member 46
chr1_+_40399618 0.348 NM_012421
RLF
rearranged L-myc fusion
chr11_+_64946820 0.347 NEAT1
nuclear paraspeckle assembly transcript 1 (non-protein coding)
chr13_+_48582389 0.342 NM_014923
FNDC3A
fibronectin type III domain containing 3A
chr10_+_29006530 0.342 BAMBI
BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)
chr11_-_11600118 0.341 NM_198516
GALNTL4
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 4
chr2_+_233270286 0.331 GIGYF2
GRB10 interacting GYF protein 2
chr3_+_23962518 0.331 NM_001145425
NR1D2
nuclear receptor subfamily 1, group D, member 2
chr16_+_51722285 0.329 CHD9
chromodomain helicase DNA binding protein 9
chr18_+_75968133 0.329 ADNP2
ADNP homeobox 2
chr1_+_152460381 0.328 UBAP2L
ubiquitin associated protein 2-like
chr1_+_26671488 0.327 NM_005517
HMGN2
high-mobility group nucleosomal binding domain 2
chr1_+_100276238 0.326 HIAT1
hippocampus abundant transcript 1
chr12_+_49185011 0.325 NM_173602
DIP2B
DIP2 disco-interacting protein 2 homolog B (Drosophila)
chr2_-_21081694 0.325 APOB
apolipoprotein B (including Ag(x) antigen)
chr6_+_7053183 0.323 RREB1
ras responsive element binding protein 1
chr6_+_64340388 0.323 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr12_+_49185035 0.323 DIP2B
DIP2 disco-interacting protein 2 homolog B (Drosophila)
chr16_+_55523526 0.318 HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr2_+_177965617 0.317 NM_003659
AGPS
alkylglycerone phosphate synthase
chrX_+_77246409 0.317 PGK1
phosphoglycerate kinase 1
chr4_+_106287391 0.316 NM_001127208
NM_017628
TET2

tet oncogene family member 2

chr1_+_52294554 0.316 BTF3L4
basic transcription factor 3-like 4
chr1_+_100276242 0.314 NM_033055
HIAT1
hippocampus abundant transcript 1
chr8_+_98725670 0.314 MTDH
metadherin
chr10_+_102662315 0.311 NM_001136123
NM_018121
FAM178A

family with sequence similarity 178, member A

chr11_+_12652427 0.311 NM_021961
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr12_+_68923477 0.307 CNOT2
CCR4-NOT transcription complex, subunit 2
chr1_+_159550789 0.307 NM_001035511
NM_001035512
NM_001035513
NM_003001
SDHC



succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa



chr12_+_63958949 0.307 NM_001193461
MSRB3
methionine sulfoxide reductase B3
chr2_+_233270275 0.305 GIGYF2
GRB10 interacting GYF protein 2
chr12_+_70434927 0.304 RAB21
RAB21, member RAS oncogene family
chr9_+_131937163 0.304 GPR107
G protein-coupled receptor 107
chr3_+_180348818 0.304 NM_006218
PIK3CA
phosphoinositide-3-kinase, catalytic, alpha polypeptide
chr12_-_56432375 0.303 CDK4
cyclin-dependent kinase 4
chr2_+_177965734 0.303 AGPS
alkylglycerone phosphate synthase
chr12_-_56432377 0.303 CDK4
cyclin-dependent kinase 4
chr8_+_109525010 0.302 NM_014673
TTC35
tetratricopeptide repeat domain 35
chr22_-_27993823 0.302 NM_012265
RHBDD3
rhomboid domain containing 3
chr15_-_68781662 0.302 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chrX_+_77246368 0.302 PGK1
phosphoglycerate kinase 1
chr1_+_36462583 0.301 NM_005119
THRAP3
thyroid hormone receptor associated protein 3
chr5_+_10406802 0.301 NM_005885
MARCH6
membrane-associated ring finger (C3HC4) 6
chr6_-_119712596 0.300 NM_005907
MAN1A1
mannosidase, alpha, class 1A, member 1
chr2_+_28828112 0.300 NM_206876
NM_002709
PPP1CB

protein phosphatase 1, catalytic subunit, beta isozyme

chr22_+_27993997 0.299 NM_001163285
NM_001163286
NM_001163287
NM_005243
NM_013986
EWSR1




Ewing sarcoma breakpoint region 1




chr15_-_71712605 0.299 NPTN
neuroplastin
chr2_+_64604940 0.298 NM_001002243
NM_017657
NM_203437
AFTPH


aftiphilin


chr20_+_57948803 0.298 NM_001190827
NM_022106
C20orf177

chromosome 20 open reading frame 177

chr1_+_52294563 0.298 BTF3L4
basic transcription factor 3-like 4
chr17_+_25467948 0.297 NM_032141
CCDC55
coiled-coil domain containing 55
chr3_+_114948550 0.296 NM_001690
ATP6V1A
ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr12_+_99185289 0.296 SCYL2
SCY1-like 2 (S. cerevisiae)
chr2_+_233270241 0.296 NM_001103146
NM_001103147
NM_001103148
NM_015575
GIGYF2



GRB10 interacting GYF protein 2



chr2_+_135392879 0.295 CCNT2
cyclin T2
chr15_+_39363442 0.294 LOC729082
hypothetical LOC729082
chr6_+_44463265 0.293 NM_001253
CDC5L
CDC5 cell division cycle 5-like (S. pombe)
chr8_+_109525050 0.292 TTC35
tetratricopeptide repeat domain 35
chr16_+_55523248 0.292 NM_001010989
NM_001010990
NM_014685
HERPUD1


homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1


chr17_+_7289086 0.291 NM_000747
CHRNB1
cholinergic receptor, nicotinic, beta 1 (muscle)
chr19_+_8415594 0.291 HNRNPM
heterogeneous nuclear ribonucleoprotein M
chr12_+_51686504 0.289 EIF4B
eukaryotic translation initiation factor 4B
chr15_+_43667050 0.288 PLDN
pallidin homolog (mouse)
chr8_+_67201684 0.288 NM_033058
NM_184085
NM_184086
NM_184087
TRIM55



tripartite motif containing 55



chr3_+_140545528 0.287 NM_020191
MRPS22
mitochondrial ribosomal protein S22
chr12_-_75477692 0.285 NM_001003712
NM_020841
OSBPL8

oxysterol binding protein-like 8

chr10_-_99436889 0.285 NM_021732
AVPI1
arginine vasopressin-induced 1
chr2_-_85683268 0.283 NM_001031738
TMEM150A
transmembrane protein 150A
chr11_+_105453501 0.283 NM_015423
AASDHPPT
aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
chr1_-_155374756 0.283 ETV3
ets variant 3
chr6_-_151754337 0.282 NM_020861
ZBTB2
zinc finger and BTB domain containing 2
chr17_+_40580466 0.281 NM_006460
HEXIM1
hexamethylene bis-acetamide inducible 1
chr6_-_84994032 0.281 NM_014895
KIAA1009
KIAA1009
chr21_-_37367259 0.280 NM_153682
PIGP
phosphatidylinositol glycan anchor biosynthesis, class P

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.27 9.40e-04 GO:0090304 nucleic acid metabolic process
1.08 1.07e-03 GO:0009987 cellular process
1.47 1.84e-03 GO:0046907 intracellular transport
1.16 3.00e-03 GO:0043170 macromolecule metabolic process
1.34 4.13e-03 GO:0033036 macromolecule localization
1.17 5.08e-03 GO:0044260 cellular macromolecule metabolic process
1.22 5.17e-03 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.29 6.08e-03 GO:0016070 RNA metabolic process
1.27 1.49e-02 GO:0010467 gene expression
1.32 2.89e-02 GO:0051641 cellular localization
1.39 2.96e-02 GO:0008219 cell death
1.90 3.61e-02 GO:0006913 nucleocytoplasmic transport
1.39 3.95e-02 GO:0016265 death
1.61 4.59e-02 GO:0044419 interspecies interaction between organisms

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.11 6.49e-11 GO:0044424 intracellular part
1.10 3.99e-10 GO:0005622 intracellular
1.14 5.93e-09 GO:0005737 cytoplasm
1.11 3.29e-07 GO:0043229 intracellular organelle
1.11 4.66e-07 GO:0043226 organelle
1.11 6.37e-06 GO:0043231 intracellular membrane-bounded organelle
1.11 8.82e-06 GO:0043227 membrane-bounded organelle
1.16 3.21e-05 GO:0044422 organelle part
1.15 6.54e-05 GO:0044446 intracellular organelle part
1.15 1.54e-04 GO:0005634 nucleus
1.20 2.62e-04 GO:0032991 macromolecular complex
1.26 3.01e-04 GO:0044428 nuclear part
1.34 5.25e-04 GO:0005654 nucleoplasm
1.21 8.90e-04 GO:0043234 protein complex
1.13 1.29e-03 GO:0044444 cytoplasmic part
1.24 5.00e-03 GO:0005829 cytosol
1.23 3.12e-02 GO:0031981 nuclear lumen
1.20 3.68e-02 GO:0043233 organelle lumen

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.17 9.12e-11 GO:0005515 protein binding
1.66 8.44e-04 GO:0000988 protein binding transcription factor activity
1.66 8.44e-04 GO:0000989 transcription factor binding transcription factor activity
1.07 8.86e-04 GO:0005488 binding
1.65 1.43e-03 GO:0003712 transcription cofactor activity
1.77 1.25e-02 GO:0003713 transcription coactivator activity
2.59 2.61e-02 GO:0004879 ligand-dependent nuclear receptor activity
2.61 3.73e-02 GO:0003707 steroid hormone receptor activity