Motif ID: PDX1.p2

Z-value: 0.430


Transcription factors associated with PDX1.p2:

Gene SymbolEntrez IDGene Name
PDX1 3651 pancreatic and duodenal homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PDX1chr13_+_27392136-0.107.1e-01Click!


Activity profile for motif PDX1.p2.

activity profile for motif PDX1.p2


Sorted Z-values histogram for motif PDX1.p2

Sorted Z-values for motif PDX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PDX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_21767819 0.788 NM_024697
ZNF385D
zinc finger protein 385D
chr10_+_63478974 0.768 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr1_+_62835759 0.614 NM_014495
ANGPTL3
angiopoietin-like 3
chr15_+_46285789 0.517 NM_000338
NM_001184832
SLC12A1

solute carrier family 12 (sodium/potassium/chloride transporters), member 1

chr11_+_55899675 0.450 NM_001005204
NM_001013356
OR8U1
OR8U8
olfactory receptor, family 8, subfamily U, member 1
olfactory receptor, family 8, subfamily U, member 8
chr2_-_158008763 0.408 NM_004288
CYTIP
cytohesin 1 interacting protein
chr4_+_109033868 0.399 NM_001136257
NM_152621
SGMS2

sphingomyelin synthase 2

chr3_+_101720753 0.398 TMEM45A
transmembrane protein 45A
chr11_+_22652957 0.294 GAS2
growth arrest-specific 2
chr4_+_86615275 0.282 NM_001025616
ARHGAP24
Rho GTPase activating protein 24
chr6_+_130381408 0.273 NM_001007102
NM_032438
L3MBTL3

l(3)mbt-like 3 (Drosophila)

chr21_-_30781537 0.256 NM_181608
KRTAP19-2
keratin associated protein 19-2
chr11_-_123182266 0.252 NM_001005325
OR6M1
olfactory receptor, family 6, subfamily M, member 1
chr11_+_22652894 0.219 NM_005256
GAS2
growth arrest-specific 2
chr2_-_165768798 0.213 NM_001081676
NM_001081677
NM_006922
SCN3A


sodium channel, voltage-gated, type III, alpha subunit


chr5_+_34720368 0.204 NM_001145521
NM_001145525
RAI14

retinoic acid induced 14

chr19_+_41872141 0.195 NM_152603
ZNF567
zinc finger protein 567
chr4_-_69116839 0.190 NM_001077
UGT2B17
UDP glucuronosyltransferase 2 family, polypeptide B17
chr1_+_157246305 0.181 NM_005531
IFI16
interferon, gamma-inducible protein 16
chr5_+_147628567 0.174 NM_001040129
SPINK13
serine peptidase inhibitor, Kazal type 13 (putative)
chr17_-_36725470 0.170 NM_031964
KRTAP17-1
keratin associated protein 17-1
chr15_-_42756377 0.162 NM_001145112
PATL2
protein associated with topoisomerase II homolog 2 (yeast)
chr8_+_76614757 0.153 NM_004133
HNF4G
hepatocyte nuclear factor 4, gamma
chr4_+_95595419 0.150 PDLIM5
PDZ and LIM domain 5
chr9_+_33016482 0.150 DNAJA1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr1_+_36409277 0.142 MAP7D1
MAP7 domain containing 1
chr9_+_33614214 0.136 ANXA2P2
annexin A2 pseudogene 2
chr9_-_8723893 0.132 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
PTPRD




protein tyrosine phosphatase, receptor type, D




chr10_+_118177371 0.129 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chr11_-_5130174 0.121 NM_012375
OR52A1
olfactory receptor, family 52, subfamily A, member 1
chr4_+_123380569 0.120 KIAA1109
KIAA1109
chr1_-_156657279 0.119 NM_001004476
OR10K2
olfactory receptor, family 10, subfamily K, member 2
chr11_-_4924905 0.119 NM_001005329
OR51A4
olfactory receptor, family 51, subfamily A, member 4
chr8_-_17624304 0.119 NM_001166393
MTUS1
microtubule associated tumor suppressor 1
chr6_-_55848346 0.119 BMP5
bone morphogenetic protein 5
chr16_-_21078262 0.116 NM_017539
DNAH3
dynein, axonemal, heavy chain 3
chr17_-_36409632 0.114 NM_031959
KRTAP3-2
keratin associated protein 3-2
chr14_-_46882144 0.114 NM_182830
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr9_+_124416768 0.111 NM_012364
OR1Q1
olfactory receptor, family 1, subfamily Q, member 1
chr12_-_52306348 0.109 NM_001130060
NM_006856
ATF7

activating transcription factor 7

chr1_+_28637247 0.109 NM_023923
PHACTR4
phosphatase and actin regulator 4
chr16_+_18986417 0.108 NM_016138
COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr12_-_52305900 0.105 ATF7
activating transcription factor 7
chr17_-_36403910 0.104 NM_033185
KRTAP3-3
keratin associated protein 3-3
chr13_-_109236897 0.103 NM_003749
IRS2
insulin receptor substrate 2
chr12_-_119938667 0.101 NM_022895
C12orf43
chromosome 12 open reading frame 43
chr8_+_32698892 0.101 NM_001159996
NRG1
neuregulin 1
chr17_+_7900926 0.101


chr14_+_100365162 0.100 MEG3
maternally expressed 3 (non-protein coding)
chr3_-_145049853 0.098 NM_173653
SLC9A9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr6_+_147566559 0.097 STXBP5
syntaxin binding protein 5 (tomosyn)
chr6_-_52060327 0.097 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr4_+_74500748 0.096 ALB
albumin
chr1_+_69998445 0.094 NM_020794
LRRC7
leucine rich repeat containing 7
chr6_-_131333173 0.091 EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr18_-_49944986 0.088 MBD2
methyl-CpG binding domain protein 2
chr13_-_40491491 0.088 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr10_+_116687904 0.087 NM_139169
TRUB1
TruB pseudouridine (psi) synthase homolog 1 (E. coli)
chr21_-_44824907 0.086 NM_198694
KRTAP10-5
keratin associated protein 10-5
chr3_+_35697432 0.086 NM_198399
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr14_+_20580224 0.083 NM_032572
RNASE7
ribonuclease, RNase A family, 7
chr2_-_218516950 0.082 NM_022648
TNS1
tensin 1
chr2_+_227900471 0.081 NM_020194
MFF
mitochondrial fission factor
chr12_-_119938593 0.081 C12orf43
chromosome 12 open reading frame 43
chr7_+_129057152 0.081 NM_001040110
NRF1
nuclear respiratory factor 1
chr3_+_116824840 0.080 NM_001130064
NM_002045
GAP43

growth associated protein 43

chr6_-_55848317 0.078 NM_021073
BMP5
bone morphogenetic protein 5
chr4_+_53975597 0.076 FIP1L1
FIP1 like 1 (S. cerevisiae)
chr14_-_76958984 0.076 NM_138791
NM_001113475
C14orf148

chromosome 14 open reading frame 148

chr3_+_176059763 0.075 NM_207015
NAALADL2
N-acetylated alpha-linked acidic dipeptidase-like 2
chr16_+_18986459 0.075 COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr21_-_30666417 0.074 NM_181621
KRTAP13-2
keratin associated protein 13-2
chr5_+_140698537 0.074 NM_018915
NM_032009
PCDHGA2

protocadherin gamma subfamily A, 2

chr1_-_230717850 0.072 NM_020808
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr17_+_32807040 0.071 NM_173625
C17orf78
chromosome 17 open reading frame 78
chr12_+_74071145 0.069 NM_152436
GLIPR1L2
GLI pathogenesis-related 1 like 2
chr2_-_199922047 0.068 SATB2
SATB homeobox 2
chr3_+_35658852 0.068 NM_016300
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr11_+_111294810 0.066 NM_080659
C11orf52
chromosome 11 open reading frame 52
chr4_+_74825138 0.066 NM_000584
IL8
interleukin 8
chr10_-_108448990 0.065 SORCS1
sortilin-related VPS10 domain containing receptor 1
chr7_-_11643113 0.065 THSD7A
thrombospondin, type I, domain containing 7A
chr12_+_45896511 0.065 FAM113B
family with sequence similarity 113, member B
chr4_-_39199527 0.060 UGDH
UDP-glucose 6-dehydrogenase
chr12_+_79362256 0.059 NM_001145026
PTPRQ
protein tyrosine phosphatase, receptor type, Q
chr2_-_99412694 0.059 REV1
REV1 homolog (S. cerevisiae)
chr12_-_10853940 0.059 NM_023917
TAS2R9
taste receptor, type 2, member 9
chr1_-_31251315 0.058 PUM1
pumilio homolog 1 (Drosophila)
chr11_-_57883117 0.058 NM_001005489
OR5B17
olfactory receptor, family 5, subfamily B, member 17
chr17_-_39499527 0.056 LSM12
LSM12 homolog (S. cerevisiae)
chr11_+_55297489 0.056 NM_001001967
OR5D13
olfactory receptor, family 5, subfamily D, member 13
chr6_-_123999640 0.056 NM_006073
TRDN
triadin
chr7_+_116182676 0.053


chr9_-_21218132 0.048 NM_021268
IFNA17
interferon, alpha 17
chr16_-_70339666 0.047 AP1G1
adaptor-related protein complex 1, gamma 1 subunit
chr1_-_150328153 0.047 NM_001008536
TCHHL1
trichohyalin-like 1
chr10_+_90474280 0.045 NM_001080518
LIPK
lipase, family member K
chr17_-_36418869 0.043 NM_031958
KRTAP3-1
keratin associated protein 3-1
chr12_-_102968044 0.043 NM_031302
GLT8D2
glycosyltransferase 8 domain containing 2
chr5_+_179934143 0.043 CNOT6
CCR4-NOT transcription complex, subunit 6
chr2_+_185171480 0.042 ZNF804A
zinc finger protein 804A
chr16_+_18986721 0.042 NM_001190983
COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr3_+_99350859 0.042 NM_001005514
OR5H14
olfactory receptor, family 5, subfamily H, member 14
chr12_+_10351683 0.041 NM_002262
NM_007334
KLRD1

killer cell lectin-like receptor subfamily D, member 1

chr1_-_246869181 0.041 NM_001001827
OR2T35
olfactory receptor, family 2, subfamily T, member 35
chr17_-_7023378 0.040 NM_001197216
NM_001671
ASGR1

asialoglycoprotein receptor 1

chr12_+_74071116 0.040 GLIPR1L2
GLI pathogenesis-related 1 like 2
chr1_-_202402043 0.040 NM_000537
REN
renin
chr10_-_56230953 0.039 NM_001142763
NM_001142764
NM_001142765
NM_001142766
NM_001142767
NM_001142768
NM_001142769
NM_001142770
NM_001142771
NM_001142772
NM_001142773
NM_033056
PCDH15











protocadherin-related 15











chr3_-_47909001 0.039 MAP4
microtubule-associated protein 4
chr18_-_28247193 0.039


chr8_+_11877238 0.038 NM_001033017
DEFB135
defensin, beta 135
chr3_-_110155237 0.038 NM_005459
GUCA1C
guanylate cyclase activator 1C
chr8_-_20084892 0.036 NM_001135691
NM_001142324
NM_001142325
NM_003053
SLC18A1



solute carrier family 18 (vesicular monoamine), member 1



chr4_+_169250281 0.035 NM_007193
ANXA10
annexin A10
chr2_+_203763649 0.035 RPL12
ribosomal protein L12
chr18_+_29573152 0.034 ASXL3
additional sex combs like 3 (Drosophila)
chr2_-_121964373 0.032 CLASP1
cytoplasmic linker associated protein 1
chr8_+_26569709 0.032 DPYSL2
dihydropyrimidinase-like 2
chr17_-_45629401 0.032


chr1_-_161379606 0.032 RGS5
regulator of G-protein signaling 5
chr7_+_104468614 0.031 MLL5
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
chr1_-_159786441 0.031 NM_000569
NM_001127592
FCGR3A

Fc fragment of IgG, low affinity IIIa, receptor (CD16a)

chr1_+_161305188 0.031 NM_005613
RGS4
regulator of G-protein signaling 4
chr2_+_105799354 0.031 NCK2
NCK adaptor protein 2
chr12_+_4569504 0.030 NM_003845
DYRK4
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr11_+_123639909 0.030 NM_001005198
OR8G5
olfactory receptor, family 8, subfamily G, member 5
chr7_+_93373755 0.029 NM_021955
GNGT1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chrX_-_131375217 0.028 NM_001170701
NM_001170702
NM_001170703
MBNL3


muscleblind-like 3 (Drosophila)


chrX_+_123307812 0.028 NM_001114937
NM_002351
SH2D1A

SH2 domain containing 1A

chr2_+_169634330 0.027 DHRS9
dehydrogenase/reductase (SDR family) member 9
chrX_+_118592879 0.027 UBE2A
ubiquitin-conjugating enzyme E2A (RAD6 homolog)
chr6_+_144654565 0.027 NM_007124
UTRN
utrophin
chr10_+_126620681 0.026 NM_017580
ZRANB1
zinc finger, RAN-binding domain containing 1
chr17_-_36444626 0.026 NM_030966
KRTAP1-3
keratin associated protein 1-3
chr7_+_156128431 0.026 NM_001184997
RNF32
ring finger protein 32
chr14_-_57133361 0.026 NM_001080455
SLC35F4
solute carrier family 35, member F4
chr6_-_26151863 0.026 NM_021062
HIST1H2BB
histone cluster 1, H2bb
chrX_+_118592568 0.026 UBE2A
ubiquitin-conjugating enzyme E2A (RAD6 homolog)
chr11_+_6823458 0.026 NM_178168
OR10A5
olfactory receptor, family 10, subfamily A, member 5
chr12_+_21417068 0.025 NM_000415
IAPP
islet amyloid polypeptide
chr11_+_88550687 0.025 NM_000372
TYR
tyrosinase (oculocutaneous albinism IA)
chr3_+_149930656 0.025 NM_032049
AGTR1
angiotensin II receptor, type 1
chr4_+_187424336 0.024 F11
coagulation factor XI
chr12_-_101835510 0.024 NM_000277
PAH
phenylalanine hydroxylase
chr10_-_62002672 0.024 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chrX_-_62697473 0.023 LOC92249
hypothetical LOC92249
chr12_+_45896318 0.022 NM_138371
FAM113B
family with sequence similarity 113, member B
chr2_+_24660849 0.022 NM_003743
NM_147223
NM_147233
NCOA1


nuclear receptor coactivator 1


chr8_+_110443881 0.022 NM_177531
PKHD1L1
polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1
chr8_-_7331313 0.021 NM_152251
NM_001040704
DEFB106A
DEFB106B
defensin, beta 106A
defensin, beta 106B
chr2_+_38746742 0.021 GALM
galactose mutarotase (aldose 1-epimerase)
chr11_-_55661769 0.021 NM_001004064
OR8J3
olfactory receptor, family 8, subfamily J, member 3
chr2_+_17861266 0.019 NM_001105569
MSGN1
mesogenin 1
chr18_+_27152049 0.018 NM_001942
DSG1
desmoglein 1
chr21_-_30631882 0.018 NM_001077711
KRTAP27-1
keratin associated protein 27-1
chr1_-_150463292 0.018 NM_001009931
HRNR
hornerin
chr17_-_39499463 0.018 LSM12
LSM12 homolog (S. cerevisiae)
chr11_-_5178505 0.018 NM_001004760
OR51V1
olfactory receptor, family 51, subfamily V, member 1
chr4_+_77575276 0.017 NM_020859
SHROOM3
shroom family member 3
chr11_+_123945102 0.017 NM_001005194
OR8A1
olfactory receptor, family 8, subfamily A, member 1
chr19_-_55539769 0.017 NAPSB
napsin B aspartic peptidase pseudogene
chr1_-_245942679 0.017 NM_001005286
OR6F1
olfactory receptor, family 6, subfamily F, member 1
chr17_-_36559579 0.016 NM_033188
KRTAP4-5
keratin associated protein 4-5
chr8_-_17599438 0.015 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr1_-_33613729 0.015 NM_198040
PHC2
polyhomeotic homolog 2 (Drosophila)
chr3_+_49522871 0.015 DAG1
dystroglycan 1 (dystrophin-associated glycoprotein 1)
chr2_-_183095308 0.015 NM_005019
NM_001003683
PDE1A

phosphodiesterase 1A, calmodulin-dependent

chr7_+_142459538 0.014 NM_001001667
OR6V1
olfactory receptor, family 6, subfamily V, member 1
chr4_-_155753249 0.013 FGG
fibrinogen gamma chain
chr11_+_89458765 0.013 NM_001143975
UBTFL1
upstream binding transcription factor, RNA polymerase I-like 1
chr11_-_55684368 0.013 NM_001004058
OR8K5
olfactory receptor, family 8, subfamily K, member 5
chr9_+_81377419 0.012 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr1_-_159867781 0.012 NM_000570
FCGR3B
Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
chr18_+_19286784 0.011 NM_003831
RIOK3
RIO kinase 3 (yeast)
chr14_+_57964462 0.011 NM_014749
KIAA0586
KIAA0586
chr4_+_187424111 0.011 NM_000128
F11
coagulation factor XI
chr9_+_96561750 0.010 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr1_+_161305558 0.010 NM_001113381
RGS4
regulator of G-protein signaling 4
chr11_-_116168316 0.010 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr3_+_110024234 0.010 NM_016388
TRAT1
T cell receptor associated transmembrane adaptor 1
chr17_-_39500512 0.009 NM_152344
LSM12
LSM12 homolog (S. cerevisiae)
chr4_-_170314382 0.007 SH3RF1
SH3 domain containing ring finger 1
chr6_-_41362370 0.007 NM_018643
TREM1
triggering receptor expressed on myeloid cells 1
chr18_+_59374372 0.006 NM_080474
SERPINB12
serpin peptidase inhibitor, clade B (ovalbumin), member 12
chr1_+_184532027 0.006 NM_001127708
NM_001127709
NM_001127710
NM_005807
PRG4



proteoglycan 4



chr12_-_48902692 0.005 NM_001113547
LIMA1
LIM domain and actin binding 1
chr8_-_17624009 0.005 NM_001001931
MTUS1
microtubule associated tumor suppressor 1
chr21_-_30460841 0.005 NM_012131
CLDN17
claudin 17
chr4_-_140280031 0.004 NM_201999
ELF2
E74-like factor 2 (ets domain transcription factor)
chrX_+_99786044 0.003 SRPX2
sushi-repeat containing protein, X-linked 2
chr11_-_66201894 0.003 RBM4B
RNA binding motif protein 4B
chr14_+_38653177 0.002 NM_001009182
NM_001009183
NM_003616
SIP1


survival of motor neuron protein interacting protein 1


chr1_+_84382575 0.001 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr12_+_10074542 0.001 NM_207345
CLEC9A
C-type lectin domain family 9, member A
chr9_+_140226457 0.001 NM_001145249
FAM157B
family with sequence similarity 157, member B
chr5_-_142795269 0.001 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr17_-_26665213 0.001 EVI2B
ecotropic viral integration site 2B
chr8_+_92330691 0.000 NM_052832
NM_134266
SLC26A7

solute carrier family 26, member 7


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
4.87 7.80e-06 GO:0007608 sensory perception of smell
4.59 8.62e-06 GO:0007606 sensory perception of chemical stimulus
3.17 3.12e-04 GO:0007600 sensory perception
2.21 4.90e-03 GO:0003008 system process
2.35 8.05e-03 GO:0050877 neurological system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
5.71 5.46e-04 GO:0045111 intermediate filament cytoskeleton
6.00 9.89e-04 GO:0005882 intermediate filament
1.62 2.88e-03 GO:0071944 cell periphery
2.08 1.33e-02 GO:0005856 cytoskeleton
1.56 1.47e-02 GO:0005886 plasma membrane
7.52 2.15e-02 GO:0045095 keratin filament
2.30 2.36e-02 GO:0044430 cytoskeletal part

Gene overrepresentation in function category:

enrichment   p-value GO term description
5.11 8.52e-07 GO:0004984 olfactory receptor activity
2.81 1.65e-03 GO:0004930 G-protein coupled receptor activity
2.09 4.85e-03 GO:0004872 receptor activity
1.92 9.56e-03 GO:0004871 signal transducer activity
1.92 9.56e-03 GO:0060089 molecular transducer activity
2.11 4.44e-02 GO:0004888 transmembrane receptor activity