Motif ID: PITX1..3.p2

Z-value: 4.385


Transcription factors associated with PITX1..3.p2:

Gene SymbolEntrez IDGene Name
PITX1 5307 paired-like homeodomain 1
PITX2 5308 paired-like homeodomain 2
PITX3 5309 paired-like homeodomain 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PITX1chr5_-_1343974700.439.5e-02Click!
PITX2chr4_-_1117636550.332.1e-01Click!
PITX3chr10_-_103991219-0.155.9e-01Click!


Activity profile for motif PITX1..3.p2.

activity profile for motif PITX1..3.p2


Sorted Z-values histogram for motif PITX1..3.p2

Sorted Z-values for motif PITX1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PITX1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_116196505 4.077 NM_030767
AKNA
AT-hook transcription factor
chr19_-_10152056 3.925


chr17_-_1037312 3.853 NM_001159746
ABR
active BCR-related gene
chr22_-_36305883 3.587 NM_006498
LGALS2
lectin, galactoside-binding, soluble, 2
chr22_+_40372957 3.575 XRCC6
X-ray repair complementing defective repair in Chinese hamster cells 6
chr7_+_74962234 3.552 NM_001099435
SPDYE5
speedy homolog E5 (Xenopus laevis)
chr3_+_50259329 3.480 NM_001166425
GNAI2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
chr19_+_53656317 3.447 NM_170720
KCNJ14
potassium inwardly-rectifying channel, subfamily J, member 14
chr17_-_10500189 3.421 NM_002470
MYH3
myosin, heavy chain 3, skeletal muscle, embryonic
chr17_+_29707583 3.392 NM_005408
CCL13
chemokine (C-C motif) ligand 13
chr11_+_35154775 3.333 CD44
CD44 molecule (Indian blood group)
chr19_-_2036227 3.298 MOBKL2A
MOB1, Mps One Binder kinase activator-like 2A (yeast)
chr16_+_48879323 3.246 NM_001114
ADCY7
adenylate cyclase 7
chr19_+_50287999 3.207 LRRC68
leucine rich repeat containing 68
chr19_-_5821546 3.191 NM_002034
FUT5
fucosyltransferase 5 (alpha (1,3) fucosyltransferase)
chr12_-_55042793 3.163 NM_001638
APOF
apolipoprotein F
chr17_-_30838870 3.021 NM_001195790
SLFN12L
schlafen family member 12-like
chr19_+_52532210 2.997 NM_018485
GPR77
G protein-coupled receptor 77
chr19_-_43926953 2.967 NM_144691
CAPN12
calpain 12
chr19_-_2207415 2.955 NM_144616
JSRP1
junctional sarcoplasmic reticulum protein 1
chr5_-_145503190 2.871 LARS
leucyl-tRNA synthetase
chr19_+_10083196 2.868 NM_002566
P2RY11
purinergic receptor P2Y, G-protein coupled, 11
chr6_+_31706345 2.866 PRRC2A
proline-rich coiled-coil 2A
chr17_-_71995401 2.857 NM_001005498
RHBDF2
rhomboid 5 homolog 2 (Drosophila)
chr1_-_154536051 2.778 NM_001004319
VHLL
von Hippel-Lindau tumor suppressor-like
chr12_-_131882616 2.769


chr19_-_5797465 2.734 FUT3
fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
chr19_+_16115454 2.701 HSH2D
hematopoietic SH2 domain containing
chr4_+_114330 2.688 ZNF718
zinc finger protein 718
chr16_+_30118036 2.662 NM_001017390
NM_177552
SULT1A4
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr19_+_50234135 2.636 NM_007056
CLASRP
CLK4-associating serine/arginine rich protein
chr22_-_27787793 2.608 NM_015370
C22orf31
chromosome 22 open reading frame 31
chr7_+_44007012 2.591 NM_175064
SPDYE1
speedy homolog E1 (Xenopus laevis)
chr19_-_8473473 2.562 NM_032152
PRAM1
PML-RARA regulated adaptor molecule 1
chr4_-_1185144 2.561 LOC100130872
hypothetical LOC100130872
chr1_-_226679648 2.520 NM_003493
HIST3H3
histone cluster 3, H3
chr19_-_54857003 2.500 IRF3
interferon regulatory factor 3
chr12_+_108149558 2.488 ACACB
acetyl-CoA carboxylase beta
chr19_-_50506883 2.465 CKM
creatine kinase, muscle
chr1_-_9040141 2.428 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr16_+_56230707 2.422 NM_001145774
GPR56
G protein-coupled receptor 56
chr22_+_19248733 2.414 MED15
mediator complex subunit 15
chr15_+_83160914 2.414 NM_020778
ALPK3
alpha-kinase 3
chr1_+_207668787 2.407 NM_001104548
LOC642587
NPC-A-5
chrX_-_70243362 2.400 NM_001025265
CXorf65
chromosome X open reading frame 65
chr11_+_65403859 2.333 NM_001335
CTSW
cathepsin W
chr17_+_69875140 2.323 NM_181790
GPR142
G protein-coupled receptor 142
chr9_+_6710862 2.319 NM_001146696
KDM4C
lysine (K)-specific demethylase 4C
chr3_+_188222337 2.301 NM_003032
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr7_+_5886952 2.266 NM_001097622
OCM
oncomodulin
chr19_-_5790702 2.252 NM_000150
NM_001040701
FUT6

fucosyltransferase 6 (alpha (1,3) fucosyltransferase)

chr19_+_49894260 2.229 NM_001039213
CEACAM16
carcinoembryonic antigen-related cell adhesion molecule 16
chr12_+_50568010 2.227 NM_001130015
NM_182608
ANKRD33

ankyrin repeat domain 33

chrX_+_102852492 2.209 NM_182541
TMEM31
transmembrane protein 31
chr17_-_44400952 2.200 NM_004123
GIP
gastric inhibitory polypeptide
chr19_+_14460757 2.189 NM_001146693
LOC100130932
small nuclear ribonucleoprotein G-like protein
chr4_+_1864306 2.162 NM_007331
NM_133330
NM_133331
NM_133335
WHSC1



Wolf-Hirschhorn syndrome candidate 1



chr4_+_6693282 2.161 NM_033296
MRFAP1
Morf4 family associated protein 1
chr19_-_17793312 2.149 NM_005543
INSL3
insulin-like 3 (Leydig cell)
chrX_-_18600108 2.116 NM_000330
RS1
retinoschisin 1
chr1_+_158387975 2.083 NM_144699
ATP1A4
ATPase, Na+/K+ transporting, alpha 4 polypeptide
chrX_-_114158388 2.081 NM_000640
IL13RA2
interleukin 13 receptor, alpha 2
chrX_-_129099695 2.080 NM_001130846
AIFM1
apoptosis-inducing factor, mitochondrion-associated, 1
chr19_+_49972965 2.079 NM_001130852
NM_012116
CBLC

Cas-Br-M (murine) ecotropic retroviral transforming sequence c

chr16_+_3499894 2.077 NM_024793
CLUAP1
clusterin associated protein 1
chr19_-_47638890 2.034 NM_198477
CXCL17
chemokine (C-X-C motif) ligand 17
chr8_-_124322764 2.026 NM_032847
C8orf76
chromosome 8 open reading frame 76
chr17_+_37340401 1.990 NM_031421
TTC25
tetratricopeptide repeat domain 25
chr1_-_159474503 1.986 NM_001077469
NM_001077470
NM_001077471
NM_001077472
NM_001077473
NM_001077474
NM_001077475
NM_001077476
NM_001077477
NM_001077478
NM_001077479
NM_001077480
NM_001077481
NM_001077482
NM_005122
NR1I3














nuclear receptor subfamily 1, group I, member 3














chr1_+_36409277 1.974 MAP7D1
MAP7 domain containing 1
chr11_+_118561375 1.973 NM_001168468
NM_024791
PDZD3

PDZ domain containing 3

chr15_+_40484249 1.947 NM_173089
NM_173090
CAPN3

calpain 3, (p94)

chr22_+_37747063 1.946 NM_152426
APOBEC3D
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D
chr19_+_4134350 1.945 NM_133475
ANKRD24
ankyrin repeat domain 24
chr22_+_19248810 1.942 MED15
mediator complex subunit 15
chr12_-_47464143 1.940 NM_015270
ADCY6
adenylate cyclase 6
chr19_+_55571493 1.925 NM_007121
NR1H2
nuclear receptor subfamily 1, group H, member 2
chrX_-_71413804 1.924 NM_001007
RPS4X
ribosomal protein S4, X-linked
chr13_+_26896614 1.922 NM_002097
GTF3A
general transcription factor IIIA
chr19_+_13719677 1.920 NM_030818
CCDC130
coiled-coil domain containing 130
chr12_-_122160927 1.919 NM_020845
PITPNM2
phosphatidylinositol transfer protein, membrane-associated 2
chr22_-_16060485 1.918 NM_177405
CECR1
cat eye syndrome chromosome region, candidate 1
chr2_+_96566190 1.896 NM_212481
ARID5A
AT rich interactive domain 5A (MRF1-like)
chr3_-_197422653 1.893 NM_001039617
ZDHHC19
zinc finger, DHHC-type containing 19
chr1_-_226357663 1.888 C1orf35
chromosome 1 open reading frame 35
chr16_-_2710552 1.878 NM_031948
PRSS27
protease, serine 27
chr19_+_3679373 1.876 NM_014428
TJP3
tight junction protein 3 (zona occludens 3)
chr16_+_65558878 1.873 NM_001185176
CES3
carboxylesterase 3
chr15_-_63199228 1.861 PDCD7
programmed cell death 7
chr17_+_38412267 1.853 NM_005533
IFI35
interferon-induced protein 35
chr10_+_70172257 1.836 CCAR1
cell division cycle and apoptosis regulator 1
chr7_-_98643024 1.825 NM_001145715
KPNA7
karyopherin alpha 7 (importin alpha 8)
chr17_+_17548888 1.813


chr19_-_18763077 1.810 NM_000095
COMP
cartilage oligomeric matrix protein
chr1_-_17180659 1.801 NM_001135247
NM_017459
MFAP2

microfibrillar-associated protein 2

chr11_-_62218759 1.800 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr19_+_2340768 1.795 NM_182973
TMPRSS9
transmembrane protease, serine 9
chr19_+_24061717 1.786 NM_203282
ZNF254
zinc finger protein 254
chr22_-_16070778 1.783 NM_017424
CECR1
cat eye syndrome chromosome region, candidate 1
chr22_-_23318829 1.770 NM_207644
C22orf36
chromosome 22 open reading frame 36
chr22_+_34443863 1.754 NM_030642
APOL5
apolipoprotein L, 5
chr5_-_16791346 1.754 MYO10
myosin X
chr22_+_36412277 1.748 NM_024313
NOL12
nucleolar protein 12
chr6_+_31538934 1.746 NM_006674
HCP5
HLA complex P5
chr14_-_49932366 1.709 NM_004196
CDKL1
cyclin-dependent kinase-like 1 (CDC2-related kinase)
chr19_+_59705824 1.709 NM_002288
NM_021270
LAIR2

leukocyte-associated immunoglobulin-like receptor 2

chr7_+_156435163 1.708 NM_138400
NOM1
nucleolar protein with MIF4G domain 1
chr1_+_111573855 1.702 NM_001025199
CHI3L2
chitinase 3-like 2
chr19_-_56026559 1.685 NM_017509
NM_138563
NM_138564
KLK15


kallikrein-related peptidase 15


chr19_-_51889002 1.680 PRKD2
protein kinase D2
chr19_+_5641270 1.659 NM_033643
RPL36
ribosomal protein L36
chr11_+_68124400 1.652 PPP6R3
protein phosphatase 6, regulatory subunit 3
chr19_-_60241424 1.650 NM_001083899
NM_016363
GP6

glycoprotein VI (platelet)

chr1_-_172228673 1.645 NM_172071
RC3H1
ring finger and CCCH-type domains 1
chr7_-_6557591 1.637 NM_001145118
GRID2IP
glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein
chr22_-_16026176 1.637 NM_017829
CECR5
cat eye syndrome chromosome region, candidate 5
chr11_-_66092534 1.636 NM_003793
CTSF
cathepsin F
chr1_+_6191506 1.628 RNF207
ring finger protein 207
chr1_+_10432362 1.623 NM_001302
CORT
cortistatin
chr15_+_41906403 1.611 NM_001167941
NM_024908
WDR76

WD repeat domain 76

chr12_-_44919818 1.611 SLC38A1
solute carrier family 38, member 1
chr17_+_7279485 1.606 NM_178518
TMEM102
transmembrane protein 102
chr19_+_15765760 1.606 NM_001004466
OR10H5
olfactory receptor, family 10, subfamily H, member 5
chr1_+_24713396 1.594 RCAN3
RCAN family member 3
chr2_-_27469947 1.594 FTH1P3
ferritin, heavy polypeptide 1 pseudogene 3
chr16_+_65552600 1.589 NM_001185177
NM_024922
CES3

carboxylesterase 3

chr11_-_117718532 1.588 NM_000732
NM_001040651
CD3D

CD3d molecule, delta (CD3-TCR complex)

chr19_+_17253453 1.587 NM_152363
ANKLE1
ankyrin repeat and LEM domain containing 1
chr6_+_167658563 1.580 NM_031949
TTLL2
tubulin tyrosine ligase-like family, member 2
chr19_-_3551576 1.572 TBXA2R
thromboxane A2 receptor
chrX_+_48915127 1.566 NM_002668
PLP2
proteolipid protein 2 (colonic epithelium-enriched)
chr7_+_1536847 1.563 NM_002360
MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr19_+_17723285 1.561 NM_001161359
NM_015122
FCHO1

FCH domain only 1

chr7_-_91632525 1.559 NM_001161528
LOC401387
leucine-rich repeat and death domain-containing protein
chr9_+_129962292 1.546 NM_024112
C9orf16
chromosome 9 open reading frame 16
chr19_-_44497815 1.543 NM_020862
LRFN1
leucine rich repeat and fibronectin type III domain containing 1
chr7_-_99899829 1.537 NM_001004323
C7orf61
chromosome 7 open reading frame 61
chr5_+_176744037 1.536 NM_001167579
NM_003052
SLC34A1

solute carrier family 34 (sodium phosphate), member 1

chr19_+_951295 1.532 NM_138690
GRIN3B
glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
chr7_-_5787776 1.527 NM_207111
NM_207116
RNF216

ring finger protein 216

chr1_-_17253073 1.525 NM_003000
SDHB
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
chr19_+_7410573 1.520 NM_001130955
ARHGEF18
Rho/Rac guanine nucleotide exchange factor (GEF) 18
chr1_-_16006779 1.519 NM_001089591
UQCRHL
ubiquinol-cytochrome c reductase hinge protein-like
chr7_+_100169184 1.517 NM_003386
NM_173059
ZAN

zonadhesin

chr8_-_37847095 1.515 RAB11FIP1
RAB11 family interacting protein 1 (class I)
chr17_-_24062998 1.507 NM_152465
PROCA1
protein interacting with cyclin A1
chr5_-_139993469 1.501 NM_001040021
NM_001174104
NM_001174105
CD14


CD14 molecule


chrX_+_153101278 1.477 NM_000513
NM_001048181
OPN1MW
OPN1MW2
opsin 1 (cone pigments), medium-wave-sensitive
opsin 1 (cone pigments), medium-wave-sensitive 2
chr5_+_139907366 1.471 NM_003732
EIF4EBP3
eukaryotic translation initiation factor 4E binding protein 3
chr15_-_87565813 1.466 NM_000326
RLBP1
retinaldehyde binding protein 1
chr3_-_127810087 1.464 NM_001039783
TXNRD3IT1
thioredoxin reductase 3 intronic transcript 1
chr8_-_33544184 1.460 NM_024787
RNF122
ring finger protein 122
chr19_+_53770804 1.460 NM_004605
SULT2B1
sulfotransferase family, cytosolic, 2B, member 1
chr16_+_70599987 1.457 NM_001361
DHODH
dihydroorotate dehydrogenase
chr22_-_48835181 1.453 NM_001080447
TTLL8
tubulin tyrosine ligase-like family, member 8
chr16_-_2254318 1.451 RNPS1
RNA binding protein S1, serine-rich domain
chr7_+_101978777 1.451 NM_001166339
NM_001031618
SPDYE2L
SPDYE2
WBSCR19-like protein 3
speedy homolog E2 (Xenopus laevis)
chr1_+_154297588 1.448 NM_020387
RAB25
RAB25, member RAS oncogene family
chrX_-_48866963 1.445 NM_015698
GPKOW
G patch domain and KOW motifs
chr9_-_134271985 1.437 NM_007344
TTF1
transcription termination factor, RNA polymerase I
chr1_-_109201228 1.432 NM_152763
AKNAD1
AKNA domain containing 1
chr1_-_226357552 1.426 NM_024319
C1orf35
chromosome 1 open reading frame 35
chr2_-_46988449 1.421 MCFD2
multiple coagulation factor deficiency 2
chr17_-_76897590 1.418 NM_178519
C17orf55
chromosome 17 open reading frame 55
chr1_-_142309117 1.417


chr5_+_132460779 1.416 HSPA4
heat shock 70kDa protein 4
chr11_-_66431910 1.413 NM_022172
PC
pyruvate carboxylase
chr19_+_8335010 1.410 NM_001039667
NM_139314
ANGPTL4

angiopoietin-like 4

chrX_-_2892288 1.406 NM_000047
ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr7_+_72486044 1.404 NM_003508
FZD9
frizzled homolog 9 (Drosophila)
chr22_+_29122932 1.402 NM_012429
NM_033382
SEC14L2

SEC14-like 2 (S. cerevisiae)

chr3_+_9666184 1.401 MTMR14
myotubularin related protein 14
chr11_-_73397929 1.392 NM_003356
NM_022803
UCP3

uncoupling protein 3 (mitochondrial, proton carrier)

chr19_+_48912053 1.391 NM_019612
IRGC
immunity-related GTPase family, cinema
chr10_+_126140330 1.390 NM_001167880
NM_022126
LHPP

phospholysine phosphohistidine inorganic pyrophosphate phosphatase

chr15_-_28472854 1.382 NM_139320
NM_148911
CHRFAM7A

CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion

chr8_-_27997306 1.380 NM_001010906
C8orf80
chromosome 8 open reading frame 80
chr1_+_3658821 1.376 NM_152492
CCDC27
coiled-coil domain containing 27
chr17_+_17931924 1.355 NM_001388
DRG2
developmentally regulated GTP binding protein 2
chr10_+_135057597 1.342 NM_138384
MTG1
mitochondrial GTPase 1 homolog (S. cerevisiae)
chr1_+_159032551 1.340 NM_001033667
NM_002348
LY9

lymphocyte antigen 9

chr6_-_31960735 1.338 EHMT2
euchromatic histone-lysine N-methyltransferase 2
chr2_+_96365190 1.337 NM_015341
NCAPH
non-SMC condensin I complex, subunit H
chr4_-_40212670 1.337 NM_019027
RBM47
RNA binding motif protein 47
chrX_-_138875342 1.335 NM_001013403
CXorf66
chromosome X open reading frame 66
chr3_+_9666198 1.331 MTMR14
myotubularin related protein 14
chr1_+_40486159 1.327 NM_001008740
TMCO2
transmembrane and coiled-coil domains 2
chr4_-_38710376 1.327 NM_024943
TMEM156
transmembrane protein 156
chr6_-_143874463 1.323 NM_032020
FUCA2
fucosidase, alpha-L- 2, plasma
chr19_-_3431514 1.322 NM_001136503
C19orf77
chromosome 19 open reading frame 77
chr1_+_234748187 1.321 NM_201545
LGALS8
lectin, galactoside-binding, soluble, 8
chr1_-_148959945 1.321 NM_032132
HORMAD1
HORMA domain containing 1
chr2_-_97016027 1.314 NM_001122646
FAM178B
family with sequence similarity 178, member B
chr3_+_52212969 1.307 ALAS1
aminolevulinate, delta-, synthase 1
chr12_-_6535481 1.302 NM_001039670
NM_001193457
NM_080730
IFFO1


intermediate filament family orphan 1


chr10_-_69957589 1.296 NM_152707
SLC25A16
solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16
chr4_-_77081118 1.291 NM_001042402
NM_014435
NAAA

N-acylethanolamine acid amidase

chr3_-_130600931 1.289 RPL32P3
ribosomal protein L32 pseudogene 3
chr10_-_125843092 1.288 CHST15
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
chr12_-_116021473 1.272 NM_001168325
NM_017899
TESC

tescalcin


Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.