Motif ID: POU3F1..4.p2

Z-value: 1.158


Transcription factors associated with POU3F1..4.p2:

Gene SymbolEntrez IDGene Name
POU3F1 5453 POU class 3 homeobox 1
POU3F2 5454 POU class 3 homeobox 2
POU3F3 5455 POU class 3 homeobox 3
POU3F4 5456 POU class 3 homeobox 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
POU3F1chr1_-_38285033-0.332.1e-01Click!
POU3F3chr2_+_1048381770.292.7e-01Click!
POU3F2chr6_+_993893180.263.4e-01Click!
POU3F4chrX_+_82649924-0.039.1e-01Click!


Activity profile for motif POU3F1..4.p2.

activity profile for motif POU3F1..4.p2


Sorted Z-values histogram for motif POU3F1..4.p2

Sorted Z-values for motif POU3F1..4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU3F1..4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_13018123 1.444 NM_001164271
DLC1
deleted in liver cancer 1
chr13_+_42253685 1.213 NM_182508
C13orf30
chromosome 13 open reading frame 30
chr13_-_59485299 1.041 NM_030932
DIAPH3
diaphanous homolog 3 (Drosophila)
chr1_-_172228673 0.994 NM_172071
RC3H1
ring finger and CCCH-type domains 1
chr2_+_166137091 0.980 NM_024969
CSRNP3
cysteine-serine-rich nuclear protein 3
chr3_+_150065732 0.955 NM_001870
CPA3
carboxypeptidase A3 (mast cell)
chr2_-_47969350 0.948 NM_025133
FBXO11
F-box protein 11
chr7_-_11838260 0.943 NM_015204
THSD7A
thrombospondin, type I, domain containing 7A
chr9_-_21999270 0.919 NM_004936
NM_078487
CDKN2B

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

chr3_-_115380539 0.891 NM_000796
NM_033663
DRD3

dopamine receptor D3

chr3_+_12367993 0.832 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chr7_+_20621769 0.817 NM_001163941
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr6_-_138862273 0.804


chr2_+_114390975 0.789 ACTR3
ARP3 actin-related protein 3 homolog (yeast)
chr13_-_25687062 0.775 RNF6
ring finger protein (C3H2C3 type) 6
chr6_-_76027286 0.748 TMEM30A
transmembrane protein 30A
chr2_-_162717159 0.746 NM_002054
GCG
glucagon
chr6_+_7347878 0.732 NM_153005
RIOK1
RIO kinase 1 (yeast)
chr18_+_59593591 0.731 NM_003784
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr10_-_16604009 0.716 NM_001010908
C1QL3
complement component 1, q subcomponent-like 3
chr19_+_41872141 0.703 NM_152603
ZNF567
zinc finger protein 567
chr13_+_78068246 0.682 LOC780529
hypothetical LOC780529
chr1_-_242073094 0.670 NM_005465
NM_181690
AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

chr7_-_122627235 0.662 NM_022444
SLC13A1
solute carrier family 13 (sodium/sulfate symporters), member 1
chr2_-_37397669 0.654 NM_005813
PRKD3
protein kinase D3
chr9_-_106407728 0.647 NM_001004481
OR13C2
olfactory receptor, family 13, subfamily C, member 2
chr11_+_33306652 0.646 HIPK3
homeodomain interacting protein kinase 3
chr21_-_30855478 0.637 NM_181614
KRTAP19-7
keratin associated protein 19-7
chr7_+_57513824 0.634 NM_001159279
ZNF716
zinc finger protein 716
chr2_+_214984705 0.632 NM_001080500
VWC2L
von Willebrand factor C domain containing protein 2-like
chr6_-_114490701 0.619 NM_153612
HS3ST5
heparan sulfate (glucosamine) 3-O-sulfotransferase 5
chr19_+_59820413 0.615 NM_006669
LILRB1
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
chr5_-_86739683 0.613 CCNH
cyclin H
chr3_+_101316463 0.605 NM_001167924
C3orf26
chromosome 3 open reading frame 26
chr18_+_59705918 0.597 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr7_-_83116414 0.593 NM_012431
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr19_+_49147219 0.572 NM_013359
ZNF221
zinc finger protein 221
chr3_+_190372456 0.563 NM_198485
TPRG1
tumor protein p63 regulated 1
chrX_+_96025562 0.552 NM_013347
RPA4
replication protein A4, 30kDa
chrX_+_87888881 0.549 NM_001184771
NM_033048
CPXCR1

CPX chromosome region, candidate 1

chr14_-_80477783 0.541 C14orf145
chromosome 14 open reading frame 145
chr9_-_103187082 0.541 NM_001701
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr1_+_245818284 0.541 NM_001001915
OR2G2
olfactory receptor, family 2, subfamily G, member 2
chr14_-_94677807 0.527 NM_030621
DICER1
dicer 1, ribonuclease type III
chr3_-_161584137 0.513 NM_001190242
IFT80
intraflagellar transport 80 homolog (Chlamydomonas)
chrX_-_105169370 0.507 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr15_-_50051239 0.501 NM_138792
LEO1
Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr7_+_143437539 0.501 NM_001005480
OR2A2
olfactory receptor, family 2, subfamily A, member 2
chr2_+_190723216 0.498 NM_001042520
C2orf88
chromosome 2 open reading frame 88
chr11_-_77730573 0.496 NM_012296
GAB2
GRB2-associated binding protein 2
chr15_-_77994652 0.490 NM_001100879
ST20
suppressor of tumorigenicity 20
chr11_-_5037432 0.484 NM_001005164
OR52E2
olfactory receptor, family 52, subfamily E, member 2
chr2_+_48698440 0.479 NM_001193487
NM_006872
GTF2A1L

general transcription factor IIA, 1-like

chr13_-_59223074 0.469


chrX_-_15530112 0.464 NM_021804
ACE2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr8_+_104900591 0.464 NM_014677
RIMS2
regulating synaptic membrane exocytosis 2
chr11_-_35235325 0.455 SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr5_-_150306298 0.449 ZNF300P1
zinc finger protein 300 pseudogene 1
chr4_-_153523113 0.448 NM_001013415
FBXW7
F-box and WD repeat domain containing 7
chr18_+_65219114 0.444 NM_152721
DOK6
docking protein 6
chr5_-_41249270 0.444 NM_000065
C6
complement component 6
chr6_-_133008834 0.442 NM_138327
TAAR1
trace amine associated receptor 1
chr19_+_41418723 0.441 ZNF146
zinc finger protein 146
chr11_-_48330574 0.440 NM_001005513
OR4C45
olfactory receptor, family 4, subfamily C, member 45
chr7_-_83108682 0.438 NM_001178129
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr2_+_183289205 0.434 NM_018981
DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr7_+_91762227 0.432


chr10_-_81698840 0.430 NM_003019
SFTPD
surfactant protein D
chr18_+_52575442 0.427 WDR7
WD repeat domain 7
chr3_+_123095860 0.427 NM_001145998
NM_021082
SLC15A2

solute carrier family 15 (H+/peptide transporter), member 2

chr5_+_34720368 0.422 NM_001145521
NM_001145525
RAI14

retinoic acid induced 14

chr7_+_12217343 0.421 NM_001134232
NM_018374
TMEM106B

transmembrane protein 106B

chr1_+_157246305 0.417 NM_005531
IFI16
interferon, gamma-inducible protein 16
chr9_+_95273241 0.417 FAM120A
family with sequence similarity 120A
chr4_-_87247829 0.415 NM_138981
MAPK10
mitogen-activated protein kinase 10
chr8_-_66863841 0.413 NM_002603
PDE7A
phosphodiesterase 7A
chr13_+_40783340 0.410 NM_001110798
NM_024561
NM_018527
NAA16


N(alpha)-acetyltransferase 16, NatA auxiliary subunit


chr3_+_28406990 0.409 NM_001040432
ZCWPW2
zinc finger, CW type with PWWP domain 2
chr9_-_4142182 0.409 NM_152629
GLIS3
GLIS family zinc finger 3
chr1_-_229071957 0.409 NM_001136494
C1orf198
chromosome 1 open reading frame 198
chr13_-_48008118 0.397 RCBTB2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr2_-_201930311 0.397 NM_001127391
NM_139163
ALS2CR12

amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12

chr13_+_108046500 0.397 NM_015011
MYO16
myosin XVI
chr8_-_20084892 0.397 NM_001135691
NM_001142324
NM_001142325
NM_003053
SLC18A1



solute carrier family 18 (vesicular monoamine), member 1



chr15_-_74091817 0.395 NM_138573
NRG4
neuregulin 4
chr13_+_47948586 0.390 RB1
retinoblastoma 1
chr17_+_54997667 0.388 NM_001166301
NM_024612
DHX40

DEAH (Asp-Glu-Ala-His) box polypeptide 40

chr11_-_55661769 0.388 NM_001004064
OR8J3
olfactory receptor, family 8, subfamily J, member 3
chr3_-_126136261 0.386 NM_033049
MUC13
mucin 13, cell surface associated
chr9_+_74956601 0.382 ANXA1
annexin A1
chr15_-_53996597 0.379 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr11_-_19038803 0.376 NM_054030
MRGPRX2
MAS-related GPR, member X2
chr9_+_83733162 0.375 NM_001145197
FAM75D4
family with sequence similarity 75, member D4
chr8_-_93099040 0.375 NM_175636
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr10_+_93673544 0.374 NM_003972
BTAF1
BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae)
chr7_-_22518200 0.372 EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr11_+_108040983 0.372 NM_004398
DDX10
DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
chr5_-_58331515 0.372 NM_001197223
PDE4D
phosphodiesterase 4D, cAMP-specific
chr9_-_36365965 0.370 RNF38
ring finger protein 38
chr3_+_189425886 0.367 NM_001167671
LPP
LIM domain containing preferred translocation partner in lipoma
chr12_+_102859354 0.364 HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr10_-_113923507 0.363 GPAM
glycerol-3-phosphate acyltransferase, mitochondrial
chr20_+_11819364 0.358 NM_181443
BTBD3
BTB (POZ) domain containing 3
chr9_-_32516164 0.358 NM_014314
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr5_+_159781413 0.357 NM_004219
PTTG1
pituitary tumor-transforming 1
chr15_-_48626193 0.354 NM_203494
USP50
ubiquitin specific peptidase 50
chr17_-_36165050 0.354 NM_181534
KRT25
keratin 25
chr17_-_2943039 0.352 NM_002548
OR1D2
olfactory receptor, family 1, subfamily D, member 2
chr5_+_43645018 0.349 NNT
nicotinamide nucleotide transhydrogenase
chr2_-_206790871 0.347 NM_001098199
NM_005279
GPR1

G protein-coupled receptor 1

chr12_+_54172413 0.346 NM_001005519
OR6C68
olfactory receptor, family 6, subfamily C, member 68
chr1_-_108536885 0.345 NM_213651
SLC25A24
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
chr5_+_134331494 0.344 NM_178019
CATSPER3
cation channel, sperm associated 3
chr9_-_85773899 0.344 HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr4_+_71096830 0.344 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr21_-_26294332 0.340 APP
amyloid beta (A4) precursor protein
chr6_-_131333173 0.340 EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr12_-_51153788 0.336 NM_173086
KRT6C
keratin 6C
chr8_-_146173531 0.336 ZNF252
zinc finger protein 252
chr8_+_107807415 0.331 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr1_+_185064654 0.326 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr2_-_113526910 0.325 NM_014438
NM_173178
IL1F8

interleukin 1 family, member 8 (eta)

chr17_-_36376663 0.324 NM_213656
KRT39
keratin 39
chr1_+_169549996 0.323 NM_002022
FMO4
flavin containing monooxygenase 4
chr9_+_74956494 0.320 NM_000700
ANXA1
annexin A1
chr17_-_4113777 0.320 NM_016376
NM_020740
ANKFY1

ankyrin repeat and FYVE domain containing 1

chr5_+_147754467 0.317 FBXO38
F-box protein 38
chr11_+_104986009 0.315 NM_000829
NM_001077243
NM_001077244
GRIA4


glutamate receptor, ionotrophic, AMPA 4


chr1_-_152445432 0.315 NM_001010979
C1orf189
chromosome 1 open reading frame 189
chr3_-_153541468 0.314 NM_001123228
TMEM14E
transmembrane protein 14E
chr12_-_52939636 0.312 NM_001127321
CBX5
chromobox homolog 5
chr8_-_125252884 0.311 C8orf78
chromosome 8 open reading frame 78
chr1_-_143786993 0.309 NM_022359
PDE4DIP
phosphodiesterase 4D interacting protein
chr1_-_152394215 0.307 NM_001159484
NM_207308
NUP210L

nucleoporin 210kDa-like

chr1_+_239882202 0.304 NM_144625
WDR64
WD repeat domain 64
chrX_-_123925343 0.299 NM_001163278
NM_001163279
NM_014253
ODZ1


odz, odd Oz/ten-m homolog 1(Drosophila)


chr10_+_124141808 0.299 NM_021622
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chrX_+_47752113 0.298 NM_001079900
SPACA5
SPACA5B
sperm acrosome associated 5
sperm acrosome associated 5B
chr9_-_110815542 0.297 NM_003798
CTNNAL1
catenin (cadherin-associated protein), alpha-like 1
chr6_-_138862271 0.295 NM_001144060
NHSL1
NHS-like 1
chr3_+_100840129 0.295 NM_001850
NM_020351
COL8A1

collagen, type VIII, alpha 1

chr20_-_9767406 0.295 NM_020341
NM_177990
PAK7

p21 protein (Cdc42/Rac)-activated kinase 7

chr12_+_54106304 0.294 NM_001005183
OR6C76
olfactory receptor, family 6, subfamily C, member 76
chr16_+_68238460 0.292 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr1_-_156078115 0.291 NM_005894
CD5L
CD5 molecule-like
chr15_-_54175954 0.290 RFX7
regulatory factor X, 7
chr1_+_78243181 0.289 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr14_+_74353417 0.287 YLPM1
YLP motif containing 1
chr12_+_70618892 0.286 NM_173353
TPH2
tryptophan hydroxylase 2
chr1_-_167663278 0.286 NM_021179
C1orf114
chromosome 1 open reading frame 114
chr5_+_55276278 0.285 RPL41P5
ribosomal protein L41 pseudogene 5
chr7_-_99219639 0.284 NM_017460
CYP3A4
cytochrome P450, family 3, subfamily A, polypeptide 4
chr14_-_62638336 0.281 NM_172376
KCNH5
potassium voltage-gated channel, subfamily H (eag-related), member 5
chr3_+_70068440 0.280 NM_000248
NM_001184968
NM_198158
NM_198178
MITF



microphthalmia-associated transcription factor



chr11_+_71580816 0.278 NM_016729
FOLR1
folate receptor 1 (adult)
chr9_+_74956614 0.277 ANXA1
annexin A1
chr12_-_60872814 0.276 NM_178539
FAM19A2
family with sequence similarity 19 (chemokine (C-C motif)-like), member A2
chr12_-_10846435 0.276 NM_023919
TAS2R7
taste receptor, type 2, member 7
chr14_+_95915774 0.275 NM_016472
C14orf129
chromosome 14 open reading frame 129
chr10_-_51678318 0.271 NM_001143974
NM_019893
ASAH2

N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2

chr9_-_92444886 0.271 NM_017594
DIRAS2
DIRAS family, GTP-binding RAS-like 2
chr8_+_50147455 0.270 NM_001007176
C8orf22
chromosome 8 open reading frame 22
chr1_+_169326641 0.269 NM_001002294
NM_006894
FMO3

flavin containing monooxygenase 3

chr9_-_114814286 0.269 NM_001101338
ZNF883
zinc finger protein 883
chr11_-_5964790 0.266 NM_001005173
OR52L1
olfactory receptor, family 52, subfamily L, member 1
chr17_+_65582981 0.265 NM_018658
NM_170741
KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr1_-_89364273 0.262 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chr14_+_19365447 0.261 NM_001004723
OR4N2
olfactory receptor, family 4, subfamily N, member 2
chr8_-_15140162 0.261 NM_139167
SGCZ
sarcoglycan, zeta
chr15_-_68781662 0.259 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr4_+_70928718 0.259 NM_000200
HTN3
histatin 3
chr2_-_74235860 0.258


chr3_+_171112053 0.255 NM_182610
SAMD7
sterile alpha motif domain containing 7
chr7_-_87180499 0.253 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr12_+_10015274 0.252 NM_138337
NM_201623
CLEC12A

C-type lectin domain family 12, member A

chr9_+_4829763 0.251 RCL1
RNA terminal phosphate cyclase-like 1
chr1_+_196392513 0.248 NM_133494
NEK7
NIMA (never in mitosis gene a)-related kinase 7
chr1_-_156937065 0.248 NM_001005279
OR6K2
olfactory receptor, family 6, subfamily K, member 2
chr6_+_49575629 0.248 NM_001010904
GLYATL3
glycine-N-acyltransferase-like 3
chr9_-_124370576 0.246 NM_001004454
OR1L8
olfactory receptor, family 1, subfamily L, member 8
chr4_+_100957003 0.244 NM_014395
DAPP1
dual adaptor of phosphotyrosine and 3-phosphoinositides
chr5_+_113797125 0.241 NM_170775
KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr12_-_44877769 0.240 SLC38A1
solute carrier family 38, member 1
chr1_-_91260357 0.238 ZNF644
zinc finger protein 644
chr5_-_156935283 0.238


chr6_+_121798443 0.238 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr21_-_14677310 0.237 NM_006948
HSPA13
heat shock protein 70kDa family, member 13
chr3_+_44667504 0.235 ZNF35
zinc finger protein 35
chr20_+_764710 0.234 NM_207121
FAM110A
family with sequence similarity 110, member A
chr12_+_50342814 0.234 NM_001177984
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr11_+_55776251 0.233 NM_001004747
OR5T3
olfactory receptor, family 5, subfamily T, member 3
chr9_-_5958367 0.233


chr8_-_62764839 0.232 NM_001164750
NM_001164751
NM_001164752
NM_001164753
NM_020164
NM_032467
NM_032468
ASPH






aspartate beta-hydroxylase






chrX_+_114734074 0.231 NM_001136025
NM_001172335
PLS3

plastin 3

chr19_-_59495949 0.229 NM_001172654
NM_006865
LILRB2
LILRA3

LILRA6
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3

leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
chr8_-_124613557 0.229 NM_148177
FBXO32
F-box protein 32
chr5_+_112101454 0.228 NM_000038
NM_001127510
APC

adenomatous polyposis coli

chr3_-_194579207 0.228 NM_198505
ATP13A5
ATPase type 13A5
chr1_+_195179533 0.228 NM_005666
CFHR2
complement factor H-related 2
chr12_+_94391952 0.226 NM_006838
METAP2
methionyl aminopeptidase 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.01 3.96e-11 GO:0007606 sensory perception of chemical stimulus
3.03 6.58e-10 GO:0007608 sensory perception of smell
2.22 7.13e-08 GO:0007600 sensory perception
1.73 2.50e-06 GO:0003008 system process
1.79 1.54e-05 GO:0050877 neurological system process
1.27 3.46e-04 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.42 1.45e-07 GO:0071944 cell periphery
1.41 4.21e-07 GO:0005886 plasma membrane
1.16 3.33e-02 GO:0016020 membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.17 2.26e-11 GO:0004984 olfactory receptor activity
2.34 1.33e-10 GO:0004930 G-protein coupled receptor activity
1.74 1.86e-07 GO:0004872 receptor activity
1.86 4.60e-07 GO:0004888 transmembrane receptor activity
1.58 9.56e-06 GO:0004871 signal transducer activity
1.58 9.56e-06 GO:0060089 molecular transducer activity