Motif ID: POU6F1.p2

Z-value: 0.877


Transcription factors associated with POU6F1.p2:

Gene SymbolEntrez IDGene Name
POU6F1 5463 POU class 6 homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
POU6F1chr12_-_49897743-0.401.3e-01Click!


Activity profile for motif POU6F1.p2.

activity profile for motif POU6F1.p2


Sorted Z-values histogram for motif POU6F1.p2

Sorted Z-values for motif POU6F1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU6F1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_13018123 1.895 NM_001164271
DLC1
deleted in liver cancer 1
chr3_-_121117647 1.157 GSK3B
glycogen synthase kinase 3 beta
chr2_-_72224696 0.946 CYP26B1
cytochrome P450, family 26, subfamily B, polypeptide 1
chr9_-_106420305 0.909 NM_001001956
OR13C9
olfactory receptor, family 13, subfamily C, member 9
chr4_+_42590038 0.909 NM_001080476
GRXCR1
glutaredoxin, cysteine rich 1
chr14_-_60022487 0.868 NM_174978
C14orf39
chromosome 14 open reading frame 39
chr18_+_59295123 0.814 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr3_+_99350859 0.760 NM_001005514
OR5H14
olfactory receptor, family 5, subfamily H, member 14
chr9_+_80134302 0.759 PSAT1
phosphoserine aminotransferase 1
chr4_+_95595419 0.736 PDLIM5
PDZ and LIM domain 5
chr13_-_25687062 0.731 RNF6
ring finger protein (C3H2C3 type) 6
chr3_-_191650291 0.699 NM_207316
TMEM207
transmembrane protein 207
chr21_-_26269298 0.696 APP
amyloid beta (A4) precursor protein
chr10_+_96433240 0.696 NM_000772
NM_001128925
CYP2C18

cytochrome P450, family 2, subfamily C, polypeptide 18

chr9_+_19280748 0.661 NM_017925
DENND4C
DENN/MADD domain containing 4C
chr6_-_47362102 0.644 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr2_-_225073357 0.617 CUL3
cullin 3
chr5_-_27074407 0.614 NM_016279
CDH9
cadherin 9, type 2 (T1-cadherin)
chr3_-_18455207 0.604 NM_001131010
SATB1
SATB homeobox 1
chr8_+_17440664 0.604 NM_001164771
NM_003046
SLC7A2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

chr5_+_139869819 0.580


chr8_-_67253234 0.576 NM_000756
CRH
corticotropin releasing hormone
chr14_+_38719462 0.558 PNN
pinin, desmosome associated protein
chr11_-_26550243 0.547 NM_001135091
NM_001135092
NM_145650
MUC15


mucin 15, cell surface associated


chr12_-_11106159 0.540 NM_176887
TAS2R46
taste receptor, type 2, member 46
chr7_+_18296569 0.535 HDAC9
histone deacetylase 9
chr2_-_215953818 0.533 FN1
fibronectin 1
chr5_-_160211623 0.531 NM_025153
ATP10B
ATPase, class V, type 10B
chr20_+_86121 0.528 NM_139074
DEFB127
defensin, beta 127
chr7_+_94135384 0.522 PEG10
paternally expressed 10
chr6_+_127940011 0.518 NM_001010905
C6orf58
chromosome 6 open reading frame 58
chr3_-_114047479 0.516 NM_001008784
CD200R1L
CD200 receptor 1-like
chr13_+_42253685 0.512 NM_182508
C13orf30
chromosome 13 open reading frame 30
chr14_-_56342097 0.506 NM_172337
OTX2
orthodenticle homeobox 2
chr8_-_125252884 0.504 C8orf78
chromosome 8 open reading frame 78
chr9_+_21399132 0.492 NM_002170
IFNA8
interferon, alpha 8
chr16_-_57309625 0.485 GOT2
glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)
chr5_-_95794416 0.469 NM_000439
PCSK1
proprotein convertase subtilisin/kexin type 1
chr2_+_166034402 0.467 NM_001172173
CSRNP3
cysteine-serine-rich nuclear protein 3
chr15_+_47502666 0.467 NM_002009
FGF7
fibroblast growth factor 7
chr18_+_45342398 0.466 NM_006033
LIPG
lipase, endothelial
chr3_-_56673113 0.463 NM_015224
C3orf63
chromosome 3 open reading frame 63
chrX_+_28515479 0.462 NM_014271
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr5_-_86739683 0.462 CCNH
cyclin H
chr3_+_174598937 0.455 NM_014932
NLGN1
neuroligin 1
chr6_+_53991672 0.453 NM_138569
C6orf142
chromosome 6 open reading frame 142
chr6_-_127822227 0.452 NM_014702
KIAA0408
KIAA0408
chr4_+_146250978 0.451 ABCE1
ATP-binding cassette, sub-family E (OABP), member 1
chr18_-_55136673 0.450 NM_181654
CPLX4
complexin 4
chr17_-_10313600 0.450 NM_017533
MYH4
myosin, heavy chain 4, skeletal muscle
chr22_-_38619739 0.448 NM_152512
ENTHD1
ENTH domain containing 1
chr8_-_101384633 0.447 NM_015435
RNF19A
ring finger protein 19A
chr14_-_94669547 0.443 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr14_+_19473606 0.435 NM_001004063
OR4K1
olfactory receptor, family 4, subfamily K, member 1
chr6_+_54281161 0.435 NM_014464
TINAG
tubulointerstitial nephritis antigen
chr1_-_191422346 0.418 NM_003783
B3GALT2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr6_-_123999640 0.418 NM_006073
TRDN
triadin
chr10_+_4995685 0.412 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr14_-_106270497 0.410 IGHG3
immunoglobulin heavy constant gamma 3 (G3m marker)
chr4_-_45820686 0.409 NM_173536
GABRG1
gamma-aminobutyric acid (GABA) A receptor, gamma 1
chr3_-_121065112 0.406


chr8_-_59575249 0.404 NM_000780
CYP7A1
cytochrome P450, family 7, subfamily A, polypeptide 1
chr3_+_129124591 0.404 NM_207335
KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr3_+_99288706 0.404 NM_054106
OR5AC2
olfactory receptor, family 5, subfamily AC, member 2
chr7_-_38915306 0.401 NM_014396
NM_080631
VPS41

vacuolar protein sorting 41 homolog (S. cerevisiae)

chr6_-_47361921 0.401 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr8_-_93144039 0.396


chr9_-_16717887 0.393 BNC2
basonuclin 2
chr4_-_145281237 0.392 NM_002099
GYPA
glycophorin A (MNS blood group)
chrX_+_56772391 0.369 LOC550643
hypothetical LOC550643
chr1_+_74473672 0.365 NM_015978
TNNI3K
TNNI3 interacting kinase
chr6_+_144654565 0.364 NM_007124
UTRN
utrophin
chr17_-_10265991 0.363 NM_002472
MYH8
myosin, heavy chain 8, skeletal muscle, perinatal
chr12_+_20854904 0.358 NM_019844
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr2_-_215949566 0.357 FN1
fibronectin 1
chr4_+_70896236 0.355 NM_001009181
NM_003154
STATH

statherin

chr13_-_102209422 0.352 NM_001146197
C13orf40
chromosome 13 open reading frame 40
chr17_-_36232366 0.351 NM_000421
KRT10
keratin 10
chr1_-_89437098 0.350 NM_052941
GBP4
guanylate binding protein 4
chr14_-_105524207 0.349 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr4_-_152368492 0.347 SH3D19
SH3 domain containing 19
chr11_+_55799604 0.346 NM_001004745
OR5T1
olfactory receptor, family 5, subfamily T, member 1
chr7_+_93373755 0.342 NM_021955
GNGT1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr21_-_26345294 0.340


chr3_+_99555387 0.339 NM_001005517
OR5K4
olfactory receptor, family 5, subfamily K, member 4
chr13_+_108046500 0.333 NM_015011
MYO16
myosin XVI
chr14_-_100420936 0.328 NM_001134888
RTL1
retrotransposon-like 1
chr4_-_44348414 0.324 NM_182592
YIPF7
Yip1 domain family, member 7
chr4_-_87247829 0.322 NM_138981
MAPK10
mitogen-activated protein kinase 10
chr11_-_57927457 0.322 NM_001005469
OR5B3
olfactory receptor, family 5, subfamily B, member 3
chr5_+_140200995 0.318 NM_018911
NM_031856
PCDHA8

protocadherin alpha 8

chr6_+_72983183 0.316 NM_001168410
RIMS1
regulating synaptic membrane exocytosis 1
chr1_+_213245507 0.312 NM_001017424
KCNK2
potassium channel, subfamily K, member 2
chr10_+_104493701 0.310 C10orf26
chromosome 10 open reading frame 26
chr3_-_57301749 0.309 NM_001142733
ASB14
ankyrin repeat and SOCS box containing 14
chr15_-_100280784 0.296 NM_001004195
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr4_+_90252990 0.292 NM_145715
TIGD2
tigger transposable element derived 2
chr5_-_145232723 0.292 NM_001080516
GRXCR2
glutaredoxin, cysteine rich 2
chr9_+_5440455 0.289 NM_014143
CD274
CD274 molecule
chr2_+_88966170 0.288


chr12_-_44919818 0.287 SLC38A1
solute carrier family 38, member 1
chr12_-_16652202 0.282 NM_001001395
LMO3
LIM domain only 3 (rhombotin-like 2)
chr10_+_104493621 0.282 C10orf26
chromosome 10 open reading frame 26
chr2_-_21081694 0.280 APOB
apolipoprotein B (including Ag(x) antigen)
chr2_+_166137091 0.274 NM_024969
CSRNP3
cysteine-serine-rich nuclear protein 3
chr12_-_11041740 0.272 NM_176889
TAS2R20
taste receptor, type 2, member 20
chr6_-_50045296 0.271 NM_001037729
DEFB113
defensin, beta 113
chr12_-_14024187 0.268 NM_000834
GRIN2B
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
chr7_+_119700924 0.268 NM_012281
KCND2
potassium voltage-gated channel, Shal-related subfamily, member 2
chr3_+_162697289 0.267 NM_001080440
OTOL1
otolin 1 homolog (zebrafish)
chr11_-_59390518 0.265 NM_001062
TCN1
transcobalamin I (vitamin B12 binding protein, R binder family)
chr5_+_161207262 0.264 NM_001127643
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr11_-_16454493 0.262 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chr14_-_57030227 0.260 NM_018168
C14orf105
chromosome 14 open reading frame 105
chr12_-_11075272 0.260 NM_176885
TAS2R31
taste receptor, type 2, member 31
chr1_+_185064654 0.260 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chrX_-_77801480 0.256 NM_152694
ZCCHC5
zinc finger, CCHC domain containing 5
chr7_+_113853790 0.250 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr2_+_210152399 0.250 MAP2
microtubule-associated protein 2
chr11_-_27637771 0.246 NM_001143816
NM_170735
BDNF

brain-derived neurotrophic factor

chr5_+_147775652 0.242 FBXO38
F-box protein 38
chr13_-_45577144 0.233 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr8_+_32698892 0.229 NM_001159996
NRG1
neuregulin 1
chr6_+_72653126 0.227 RIMS1
regulating synaptic membrane exocytosis 1
chr10_+_4995453 0.226 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr17_-_37794017 0.226 NM_003150
NM_139276
STAT3

signal transducer and activator of transcription 3 (acute-phase response factor)

chr3_-_112796855 0.225 NM_024508
ZBED2
zinc finger, BED-type containing 2
chr6_+_7524691 0.223 DSP
desmoplakin
chr19_+_61624 0.223 NM_001005240
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chrX_+_41468351 0.222 NM_080817
GPR82
G protein-coupled receptor 82
chr1_+_103999663 0.221 NM_001008221
AMY1A
amylase, alpha 1A (salivary)
chr3_+_70068440 0.221 NM_000248
NM_001184968
NM_198158
NM_198178
MITF



microphthalmia-associated transcription factor



chr11_+_48284350 0.220 NM_001004725
OR4S1
olfactory receptor, family 4, subfamily S, member 1
chr6_+_163904564 0.217 QKI
quaking homolog, KH domain RNA binding (mouse)
chr15_+_52092392 0.216 NM_001080534
UNC13C
unc-13 homolog C (C. elegans)
chr16_+_14201687 0.215 MKL2
MKL/myocardin-like 2
chr2_-_138762909 0.213


chr1_-_214963279 0.211 NM_001438
ESRRG
estrogen-related receptor gamma
chr10_-_128199986 0.210 NM_001004298
C10orf90
chromosome 10 open reading frame 90
chr10_+_4995597 0.210 AKR1C1
AKR1C3
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr17_-_2943039 0.208 NM_002548
OR1D2
olfactory receptor, family 1, subfamily D, member 2
chr2_+_200878848 0.207 NM_015535
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr6_-_29163027 0.201 NM_001005226
OR2B3
olfactory receptor, family 2, subfamily B, member 3
chr17_-_46479127 0.201 SPAG9
sperm associated antigen 9
chrX_+_78087484 0.199 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr4_-_145159889 0.198 NM_002100
GYPB
glycophorin B (MNS blood group)
chr8_+_17874128 0.198 PCM1
pericentriolar material 1
chr12_+_98565663 0.198 NM_153364
FAM71C
family with sequence similarity 71, member C
chr1_-_178100204 0.197


chr3_+_35658852 0.196 NM_016300
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr7_+_94130673 0.194 PEG10
paternally expressed 10
chr17_-_10362583 0.192 NM_005963
MYH1
myosin, heavy chain 1, skeletal muscle, adult
chr3_-_110517929 0.191 NM_138815
DPPA2
developmental pluripotency associated 2
chr14_-_105589467 0.189 LOC100126583
IGHA1
IGHG1
IGHG2
IGHM
hypothetical LOC100126583
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 2 (G2m marker)
immunoglobulin heavy constant mu
chr16_-_31347151 0.189 NM_005205
COX6A2
cytochrome c oxidase subunit VIa polypeptide 2
chr5_+_76284435 0.189 NM_001882
CRHBP
corticotropin releasing hormone binding protein
chr15_+_38082041 0.188 EIF2AK4
eukaryotic translation initiation factor 2 alpha kinase 4
chr4_-_164614335 0.187 NM_032136
TKTL2
transketolase-like 2
chr4_+_176076083 0.187 NM_001130703
NM_001130704
NM_001130705
NM_014269
ADAM29



ADAM metallopeptidase domain 29



chr6_+_64414389 0.187 NM_015153
PHF3
PHD finger protein 3
chr14_-_106289751 0.187 IGHA1
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr9_-_124981125 0.186 STRBP
spermatid perinuclear RNA binding protein
chr12_+_16391342 0.186 NM_145792
MGST1
microsomal glutathione S-transferase 1
chr20_-_218957 0.185 C20orf96
chromosome 20 open reading frame 96
chr17_-_36276987 0.184 NM_000223
KRT12
keratin 12
chr3_-_153470022 0.183 LOC401093
hypothetical LOC401093
chr11_-_55661769 0.183 NM_001004064
OR8J3
olfactory receptor, family 8, subfamily J, member 3
chr1_-_196776697 0.180 NM_133262
NM_133326
ATP6V1G3

ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3

chr6_-_132980901 0.179 NM_014626
TAAR2
trace amine associated receptor 2
chr3_-_115380539 0.177 NM_000796
NM_033663
DRD3

dopamine receptor D3

chr1_+_58899 0.177 NM_001005484
OR4F4
OR4F5
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 5
chr2_-_121964373 0.176 CLASP1
cytoplasmic linker associated protein 1
chr20_+_71230 0.176 NM_030931
DEFB126
defensin, beta 126
chr14_-_105523735 0.175 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chrX_+_135058402 0.175 NM_001159700
FHL1
four and a half LIM domains 1
chr17_-_36294962 0.173 NM_019010
KRT20
keratin 20
chrX_+_46938215 0.173 UBA1
ubiquitin-like modifier activating enzyme 1
chr11_+_19328846 0.169 NM_001111018
NAV2
neuron navigator 2
chr2_-_231697999 0.169 NM_000867
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B
chr11_-_57173823 0.168 NM_145008
YPEL4
yippee-like 4 (Drosophila)
chr15_+_49988882 0.168 TMOD3
tropomodulin 3 (ubiquitous)
chr2_+_183290912 0.167 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr17_-_15914485 0.166 NCOR1
nuclear receptor corepressor 1
chr1_+_93830106 0.165 LOC100129046
hypothetical LOC100129046
chr7_+_91762227 0.164


chr4_+_74825138 0.158 NM_000584
IL8
interleukin 8
chr2_-_27215781 0.156 NM_178553
C2orf53
chromosome 2 open reading frame 53
chr8_-_93177057 0.155 NM_001198625
NM_001198626
NM_001198627
NM_001198631
NM_001198634
NM_001198679
RUNX1T1





runt-related transcription factor 1; translocated to, 1 (cyclin D-related)





chr14_-_106119742 0.154 IGLJ3
IGHG1
immunoglobulin lambda joining 3
immunoglobulin heavy constant gamma 1 (G1m marker)
chr10_+_90474280 0.153 NM_001080518
LIPK
lipase, family member K
chr11_-_58736897 0.152 NM_001039396
MPEG1
macrophage expressed 1
chr3_+_100840129 0.152 NM_001850
NM_020351
COL8A1

collagen, type VIII, alpha 1

chr14_-_105862080 0.152 IGHV4-31
IGHA1
IGHD
IGHG1
IGHG2
IGHG3
IGHM
SCFV
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 2 (G2m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
single-chain Fv fragment
chr2_+_128009782 0.151 NM_001080527
MYO7B
myosin VIIB
chr8_+_36760999 0.151 NM_001031836
KCNU1
potassium channel, subfamily U, member 1
chr8_-_114518194 0.150 NM_052900
NM_198123
CSMD3

CUB and Sushi multiple domains 3

chr6_-_138231006 0.150


chr2_-_127817143 0.149 NM_006609
MAP3K2
mitogen-activated protein kinase kinase kinase 2
chrX_+_55760774 0.149 NM_006064
NM_016656
RRAGB

Ras-related GTP binding B

chr2_-_225078931 0.149 CUL3
cullin 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
4.04 3.72e-14 GO:0007606 sensory perception of chemical stimulus
3.88 2.95e-11 GO:0007608 sensory perception of smell
2.83 1.85e-10 GO:0007600 sensory perception
2.30 1.04e-09 GO:0050877 neurological system process
2.12 1.95e-09 GO:0003008 system process
1.47 1.54e-07 GO:0032501 multicellular organismal process
1.28 8.97e-03 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.53 7.65e-08 GO:0071944 cell periphery
1.52 3.02e-07 GO:0005886 plasma membrane
1.27 1.75e-03 GO:0044425 membrane part
1.52 1.46e-02 GO:0005576 extracellular region
1.26 2.40e-02 GO:0016021 integral to membrane
1.19 3.03e-02 GO:0016020 membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.91 1.75e-12 GO:0004930 G-protein coupled receptor activity
3.97 6.43e-12 GO:0004984 olfactory receptor activity
2.34 2.41e-10 GO:0004888 transmembrane receptor activity
2.07 1.88e-09 GO:0004872 receptor activity
1.86 8.34e-08 GO:0004871 signal transducer activity
1.86 8.34e-08 GO:0060089 molecular transducer activity
6.17 3.99e-02 GO:0003823 antigen binding