Motif ID: REST.p3

Z-value: 2.613


Transcription factors associated with REST.p3:

Gene SymbolEntrez IDGene Name
REST 5978 RE1-silencing transcription factor

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RESTchr4_+_57468847-0.591.7e-02Click!


Activity profile for motif REST.p3.

activity profile for motif REST.p3


Sorted Z-values histogram for motif REST.p3

Sorted Z-values for motif REST.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of REST.p3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 157 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_134447795 10.622 NM_020064
 BARHL1
BarH-like homeobox 1
chr8_-_145530639 7.313 NM_031309
 SCRT1
scratch homolog 1, zinc finger protein (Drosophila)
chr15_+_65904994 7.176 NM_001031807
 SKOR1
SKI family transcriptional corepressor 1
chr12_+_46133 5.712 NM_001170738
 IQSEC3
IQ motif and Sec7 domain 3
chr10_+_99599984 5.105 NM_001010917
 GOLGA7B
golgin A7 family, member B
chr4_+_8633116 4.246 NM_080819
 GPR78
G protein-coupled receptor 78
chr4_+_158361185 4.078 NM_000826
NM_001083619
NM_001083620
 GRIA2


glutamate receptor, ionotropic, AMPA 2


chr9_+_139153409 3.890 NM_000832
NM_001185090
NM_001185091
NM_007327
NM_021569
 GRIN1




glutamate receptor, ionotropic, N-methyl D-aspartate 1




chrX_-_152794592 3.538 NM_000425
NM_001143963
NM_024003
 L1CAM


L1 cell adhesion molecule


chr20_+_30019465 3.485 NM_001011718
 XKR7
XK, Kell blood group complex subunit-related family, member 7
chr7_+_154943466 3.391 NM_001427
 EN2
engrailed homeobox 2
chr20_-_60228665 3.370 NM_007232
 HRH3
histamine receptor H3
chr17_-_24357014 3.332 NM_001098635
NM_178860
 SEZ6

seizure related 6 homolog (mouse)

chr14_-_73962557 3.290 NM_001105579
 TMEM90A
transmembrane protein 90A
chrX_-_152794478 3.173 L1CAM
L1 cell adhesion molecule
chr2_-_27384617 3.071 NM_003353
 UCN
urocortin
chr16_+_2959362 3.006 PAQR4
progestin and adipoQ receptor family member IV
chr11_+_627268 2.995 NM_000797
 DRD4
dopamine receptor D4
chr5_+_33972247 2.991 NM_016568
 RXFP3
relaxin/insulin-like family peptide receptor 3
chr3_+_9720509 2.942 NM_153635
 CPNE9
copine family member IX

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 51 entries
enrichment   p-value GO term description
43.00 2.62e-02 GO:0032225 regulation of synaptic transmission, dopaminergic
39.42 3.47e-02 GO:0032413 negative regulation of ion transmembrane transporter activity
36.39 4.50e-02 GO:0051954 positive regulation of amine transport
28.67 6.79e-03 GO:0014073 response to tropane
28.67 6.79e-03 GO:0042220 response to cocaine
26.28 9.76e-03 GO:0060078 regulation of postsynaptic membrane potential
24.26 1.36e-02 GO:0050433 regulation of catecholamine secretion
23.36 1.59e-02 GO:0045776 negative regulation of blood pressure
21.31 2.29e-03 GO:0051952 regulation of amine transport
12.72 3.00e-02 GO:0007269 neurotransmitter secretion
11.95 4.06e-02 GO:0007631 feeding behavior
11.60 4.69e-02 GO:0030534 adult behavior
10.88 1.24e-02 GO:0001505 regulation of neurotransmitter levels
10.42 3.25e-03 GO:0003001 generation of a signal involved in cell-cell signaling
10.42 3.25e-03 GO:0023061 signal release
10.37 1.41e-04 GO:0031644 regulation of neurological system process
10.18 7.92e-04 GO:0051969 regulation of transmission of nerve impulse
10.18 1.82e-02 GO:0007626 locomotory behavior
9.37 2.90e-02 GO:0006836 neurotransmitter transport
9.19 3.24e-02 GO:0008217 regulation of blood pressure

Gene overrepresentation in compartment category:

Showing 1 to 20 of 32 entries
enrichment   p-value GO term description
78.83 3.14e-02 GO:0032590 dendrite membrane
24.53 1.65e-06 GO:0030672 synaptic vesicle membrane
14.85 8.44e-06 GO:0030665 clathrin coated vesicle membrane
14.67 9.26e-06 GO:0008021 synaptic vesicle
10.98 8.88e-05 GO:0030662 coated vesicle membrane
9.56 5.16e-03 GO:0019717 synaptosome
8.88 1.05e-04 GO:0030136 clathrin-coated vesicle
8.31 1.83e-04 GO:0043025 neuronal cell body
8.07 2.33e-04 GO:0044297 cell body
7.70 4.74e-07 GO:0044456 synapse part
7.25 5.64e-04 GO:0030135 coated vesicle
6.70 9.93e-05 GO:0030659 cytoplasmic vesicle membrane
6.53 3.61e-07 GO:0045202 synapse
6.48 1.39e-04 GO:0012506 vesicle membrane
6.40 4.73e-02 GO:0045211 postsynaptic membrane
6.17 2.52e-06 GO:0043005 neuron projection
5.85 2.64e-02 GO:0030425 dendrite
5.57 6.05e-04 GO:0044433 cytoplasmic vesicle part
3.89 1.85e-03 GO:0030054 cell junction
3.46 3.57e-03 GO:0016023 cytoplasmic membrane-bounded vesicle

Gene overrepresentation in function category:

Showing 1 to 11 of 11 entries
enrichment   p-value GO term description
105.10 1.68e-02 GO:0001591 dopamine receptor activity, coupled via Gi/Go
78.83 3.35e-02 GO:0016933 extracellular-glycine-gated ion channel activity
78.83 3.35e-02 GO:0016934 extracellular-glycine-gated chloride channel activity
36.39 9.56e-03 GO:0016594 glycine binding
22.53 4.28e-02 GO:0005184 neuropeptide hormone activity
20.13 6.89e-05 GO:0005231 excitatory extracellular ligand-gated ion channel activity
13.15 8.82e-04 GO:0005230 extracellular ligand-gated ion channel activity
7.70 1.85e-02 GO:0043176 amine binding
7.58 2.02e-02 GO:0015276 ligand-gated ion channel activity
7.58 2.02e-02 GO:0022834 ligand-gated channel activity
2.64 1.25e-02 GO:0005215 transporter activity