Motif ID: REST.p3

Z-value: 2.613


Transcription factors associated with REST.p3:

Gene SymbolEntrez IDGene Name
REST 5978 RE1-silencing transcription factor

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RESTchr4_+_57468847-0.591.7e-02Click!


Activity profile for motif REST.p3.

activity profile for motif REST.p3


Sorted Z-values histogram for motif REST.p3

Sorted Z-values for motif REST.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of REST.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_134447795 10.622 NM_020064
BARHL1
BarH-like homeobox 1
chr8_-_145530639 7.313 NM_031309
SCRT1
scratch homolog 1, zinc finger protein (Drosophila)
chr15_+_65904994 7.176 NM_001031807
SKOR1
SKI family transcriptional corepressor 1
chr12_+_46133 5.712 NM_001170738
IQSEC3
IQ motif and Sec7 domain 3
chr10_+_99599984 5.105 NM_001010917
GOLGA7B
golgin A7 family, member B
chr4_+_8633116 4.246 NM_080819
GPR78
G protein-coupled receptor 78
chr4_+_158361185 4.078 NM_000826
NM_001083619
NM_001083620
GRIA2


glutamate receptor, ionotropic, AMPA 2


chr9_+_139153409 3.890 NM_000832
NM_001185090
NM_001185091
NM_007327
NM_021569
GRIN1




glutamate receptor, ionotropic, N-methyl D-aspartate 1




chrX_-_152794592 3.538 NM_000425
NM_001143963
NM_024003
L1CAM


L1 cell adhesion molecule


chr20_+_30019465 3.485 NM_001011718
XKR7
XK, Kell blood group complex subunit-related family, member 7
chr7_+_154943466 3.391 NM_001427
EN2
engrailed homeobox 2
chr20_-_60228665 3.370 NM_007232
HRH3
histamine receptor H3
chr17_-_24357014 3.332 NM_001098635
NM_178860
SEZ6

seizure related 6 homolog (mouse)

chr14_-_73962557 3.290 NM_001105579
TMEM90A
transmembrane protein 90A
chrX_-_152794478 3.173 L1CAM
L1 cell adhesion molecule
chr2_-_27384617 3.071 NM_003353
UCN
urocortin
chr16_+_2959362 3.006 PAQR4
progestin and adipoQ receptor family member IV
chr11_+_627268 2.995 NM_000797
DRD4
dopamine receptor D4
chr5_+_33972247 2.991 NM_016568
RXFP3
relaxin/insulin-like family peptide receptor 3
chr3_+_9720509 2.942 NM_153635
CPNE9
copine family member IX
chr16_+_2959342 2.903 NM_152341
PAQR4
progestin and adipoQ receptor family member IV
chr11_+_22316242 2.692 NM_020346
SLC17A6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr19_-_3922089 2.514 DAPK3
death-associated protein kinase 3
chr19_-_3922032 2.492 DAPK3
death-associated protein kinase 3
chr14_+_92459197 2.465 NM_001275
CHGA
chromogranin A (parathyroid secretory protein 1)
chr9_-_138236775 2.252 NM_178138
LHX3
LIM homeobox 3
chr20_+_44091265 2.208 SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr1_+_152806874 2.195 NM_000748
CHRNB2
cholinergic receptor, nicotinic, beta 2 (neuronal)
chrX_-_47364039 2.175


chr8_-_145723209 2.156 NM_001024678
LRRC24
leucine rich repeat containing 24
chrX_-_47364173 2.151 NM_006950
NM_133499
SYN1

synapsin I

chr1_+_152806924 2.122 CHRNB2
cholinergic receptor, nicotinic, beta 2 (neuronal)
chr14_-_104142125 2.120 NM_207379
TMEM179
transmembrane protein 179
chr7_-_19778928 2.107 NM_152774
TMEM196
transmembrane protein 196
chr20_+_44091219 2.084 NM_020708
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr12_-_3472245 2.053 LOC100129223
hypothetical LOC100129223
chr17_+_1120607 2.050 NM_001164405
BHLHA9
basic helix-loop-helix family, member a9
chr1_-_173979292 1.897 NM_003285
TNR
tenascin R (restrictin, janusin)
chr14_+_92459244 1.887 CHGA
chromogranin A (parathyroid secretory protein 1)
chr7_+_8439762 1.841 NXPH1
neurexophilin 1
chr7_+_8440541 1.827 NXPH1
neurexophilin 1
chr5_-_175969697 1.786 NM_052899
GPRIN1
G protein regulated inducer of neurite outgrowth 1
chr12_+_111714096 1.771 RPH3A
rabphilin 3A homolog (mouse)
chr3_-_188870799 1.697 NM_001048
SST
somatostatin
chr1_+_33124658 1.677 NM_002143
HPCA
hippocalcin
chr11_-_74818685 1.645 KLHL35
kelch-like 35 (Drosophila)
chr19_+_38867273 1.601 NM_022467
CHST8
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
chr12_+_111713931 1.584 NM_001143854
NM_014954
RPH3A

rabphilin 3A homolog (mouse)

chr7_+_8440109 1.569 NM_152745
NXPH1
neurexophilin 1
chr18_-_39111243 1.506 NM_020783
SYT4
synaptotagmin IV
chr6_+_110406890 1.496 NM_005284
GPR6
G protein-coupled receptor 6
chr3_-_115380539 1.495 NM_000796
NM_033663
DRD3

dopamine receptor D3

chr11_+_45863774 1.468 NM_005456
MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1
chr3_+_122109716 1.450 NM_014980
STXBP5L
syntaxin binding protein 5-like
chr11_-_74818858 1.435 KLHL35
kelch-like 35 (Drosophila)
chr8_+_57520915 1.343


chr7_-_100595552 1.320 NM_003378
VGF
VGF nerve growth factor inducible
chr11_-_123030091 1.301 SCN3B
sodium channel, voltage-gated, type III, beta
chr17_+_77925441 1.263 NM_018949
UTS2R
urotensin 2 receptor
chr2_+_114916368 1.248 NM_020868
DPP10
dipeptidyl-peptidase 10 (non-functional)
chrX_-_48943582 1.240 NM_003179
SYP
synaptophysin
chr19_-_60383280 1.236 NM_003180
SYT5
synaptotagmin V
chr17_+_39741306 1.195 NM_001144825
NM_001144826
NM_006695
RUNDC3A


RUN domain containing 3A


chr16_+_66244314 1.187 RLTPR
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr15_-_81175542 1.175 NM_004644
AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr9_-_73251639 1.173 TRPM3
transient receptor potential cation channel, subfamily M, member 3
chr10_+_26545241 1.164 NM_000818
NM_001134366
GAD2

glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)

chr19_-_44427446 1.161 NM_172139
IL28B
interleukin 28B (interferon, lambda 3)
chr8_-_57521065 1.139 NM_006211
PENK
proenkephalin
chr11_+_62136788 1.082 NM_000327
ROM1
retinal outer segment membrane protein 1
chr10_+_73225533 1.049 NM_001171933
NM_001171934
CDH23

cadherin-related 23

chr17_-_7159094 1.038 NM_004489
GPS2
G protein pathway suppressor 2
chr19_-_45416043 1.000 TTC9B
tetratricopeptide repeat domain 9B
chr17_-_3248453 0.991 NM_003553
OR1E1
olfactory receptor, family 1, subfamily E, member 1
chr11_-_125278296 0.989 NM_031307
PUS3
pseudouridylate synthase 3
chr6_+_35881048 0.987 NM_182548
LHFPL5
lipoma HMGIC fusion partner-like 5
chr5_-_151284515 0.966 NM_000171
NM_001146040
GLRA1

glycine receptor, alpha 1

chr6_+_158877455 0.961 NM_020823
TMEM181
transmembrane protein 181
chr18_+_55718171 0.936 NM_021127
PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
chr17_+_27838041 0.906 NM_003885
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr2_+_131230252 0.873 NM_001105194
NM_001105195
FAM123C

family with sequence similarity 123C

chr11_-_27698800 0.860 NM_001143805
NM_001143806
NM_170732
BDNF


brain-derived neurotrophic factor


chr11_-_122357545 0.835 NM_001098169
BSX
brain-specific homeobox
chr10_+_26545599 0.809 GAD2
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr11_-_74819165 0.747 NM_001039548
KLHL35
kelch-like 35 (Drosophila)
chr11_-_72170533 0.732 STARD10
StAR-related lipid transfer (START) domain containing 10
chr5_+_175231098 0.690 NM_001008220
CPLX2
complexin 2
chr1_-_239587090 0.688 NM_002924
RGS7
regulator of G-protein signaling 7
chr20_+_61798512 0.688 TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr5_+_175231170 0.675


chr19_-_45416112 0.641 NM_152479
TTC9B
tetratricopeptide repeat domain 9B
chr5_+_175231210 0.640 CPLX2
complexin 2
chr19_+_51804260 0.628 CALM3
calmodulin 3 (phosphorylase kinase, delta)
chr20_+_61798446 0.623 NM_003823
TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr19_+_45728207 0.592 NM_025213
SPTBN4
spectrin, beta, non-erythrocytic 4
chr6_+_25760352 0.583 NM_006998
SCGN
secretagogin, EF-hand calcium binding protein
chr19_+_4720144 0.552 C19orf30
chromosome 19 open reading frame 30
chr5_+_71050745 0.532 NM_004291
CARTPT
CART prepropeptide
chr6_+_158877640 0.508 TMEM181
transmembrane protein 181
chr3_+_62279707 0.488 C3orf14
chromosome 3 open reading frame 14
chr17_-_3283884 0.483 NM_003554
OR1E2
olfactory receptor, family 1, subfamily E, member 2
chr19_+_45728270 0.477 SPTBN4
spectrin, beta, non-erythrocytic 4
chr5_-_135729062 0.476 NM_001167576
NM_001167577
NM_020389
TRPC7


transient receptor potential cation channel, subfamily C, member 7


chr6_-_32121784 0.450 NM_032470
TNXB
tenascin XB
chrX_+_152891184 0.441 NM_003492
TMEM187
transmembrane protein 187
chr11_-_1725924 0.419 NM_001170820
LOC402778
CD225 family protein FLJ76511
chr16_+_4948318 0.393 NM_014692
SEC14L5
SEC14-like 5 (S. cerevisiae)
chr11_+_64565118 0.386 SAC3D1
SAC3 domain containing 1
chr3_+_195336631 0.384 HES1
hairy and enhancer of split 1, (Drosophila)
chr16_+_2450081 0.375 NM_025108
C16orf59
chromosome 16 open reading frame 59
chr1_-_239587007 0.373 RGS7
regulator of G-protein signaling 7
chr1_-_102235377 0.356 NM_058170
OLFM3
olfactomedin 3
chr2_+_207215386 0.351 NM_001102659
LOC200726
hCG1657980
chr9_+_116131889 0.341 NM_000608
ORM2
orosomucoid 2
chr2_-_219791638 0.339 ABCB6
ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr11_-_1725662 0.336 LOC402778
CD225 family protein FLJ76511
chr14_-_93829347 0.313 NM_001100607
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr5_+_175231144 0.313 CPLX2
complexin 2
chr1_-_102234959 0.303 OLFM3
olfactomedin 3
chr20_+_56861430 0.302 NM_001077490
NM_080425
GNAS

GNAS complex locus

chr16_-_2125825 0.286 NM_000296
NM_001009944
PKD1

polycystic kidney disease 1 (autosomal dominant)

chr20_+_35445350 0.281 SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr15_-_70399523 0.262 CELF6
CUGBP, Elav-like family member 6
chr19_-_50429306 0.260 NM_138568
EXOC3L2
exocyst complex component 3-like 2
chr3_+_52787478 0.253 NM_001166434
ITIH1
inter-alpha (globulin) inhibitor H1
chr3_+_195336625 0.232 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr15_-_70399551 0.231 NM_052840
CELF6
CUGBP, Elav-like family member 6
chr11_-_27677755 0.223 NM_170734
BDNF
brain-derived neurotrophic factor
chr1_+_1836125 0.218 NM_138705
CALML6
calmodulin-like 6
chr8_+_11703368 0.182 FDFT1
farnesyl-diphosphate farnesyltransferase 1
chr9_+_137593420 0.161 NM_001018049
NM_002571
PAEP

progestagen-associated endometrial protein

chr10_-_44200458 0.158 NM_000609
NM_001033886
NM_001178134
NM_199168
CXCL12



chemokine (C-X-C motif) ligand 12



chr8_+_69026895 0.149 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr17_-_37022465 0.142 NM_005557
KRT16
keratin 16
chr11_-_6633427 0.131 NM_003737
DCHS1
dachsous 1 (Drosophila)
chr2_-_219791902 0.122 NM_005689
ABCB6
ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr6_+_154402135 0.121 NM_000914
NM_001008503
NM_001008504
NM_001008505
NM_001145282
NM_001145283
NM_001145285
NM_001145286
NM_001145284
OPRM1








opioid receptor, mu 1








chr5_-_70621688 0.103 SMA4
glucuronidase, beta pseudogene
chr4_-_175986952 0.102 NM_001042543
NM_006529
GLRA3

glycine receptor, alpha 3

chr9_-_122852356 0.097 NM_001735
C5
complement component 5
chr19_-_11500912 0.091 NM_001142464
NM_001142465
NM_016581
ECSIT


ECSIT homolog (Drosophila)


chr8_+_69027143 0.090 NM_024870
NM_025170
PREX2

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2

chr17_-_3546236 0.086 NM_002561
NM_175080
NM_175081
P2RX5-TAX1BP3
P2RX5


P2RX5-TAX1BP3 read-through transcript
purinergic receptor P2X, ligand-gated ion channel, 5


chr15_-_70399301 0.083 NM_001172684
CELF6
CUGBP, Elav-like family member 6
chr1_+_100777044 0.077 GPR88
G protein-coupled receptor 88
chr19_+_9064854 0.076 NM_001004456
OR1M1
olfactory receptor, family 1, subfamily M, member 1
chr8_+_69027277 0.072 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr12_+_6431437 0.069 NM_018009
TAPBPL
TAP binding protein-like
chr12_-_97812633 0.061 ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chr22_-_16636748 0.044 NM_197966
BID
BH3 interacting domain death agonist
chr8_+_80685859 0.035 STMN2
stathmin-like 2
chr19_+_15058790 0.021 NM_001004713
OR1I1
olfactory receptor, family 1, subfamily I, member 1
chr5_-_69917721 0.021 SMA4
glucuronidase, beta pseudogene
chr1_-_33108876 0.019 NM_001171940
NM_153756
FNDC5

fibronectin type III domain containing 5

chr6_+_44346457 0.010 NM_001137560
TMEM151B
transmembrane protein 151B
chr3_-_25680723 0.007 NM_001068
TOP2B
topoisomerase (DNA) II beta 180kDa
chr16_+_67902751 0.006 NM_013245
VPS4A
vacuolar protein sorting 4 homolog A (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
7.93 4.16e-10 GO:0007268 synaptic transmission
7.06 3.51e-09 GO:0019226 transmission of nerve impulse
7.06 3.51e-09 GO:0035637 multicellular organismal signaling
3.47 2.88e-08 GO:0003008 system process
3.82 5.55e-08 GO:0050877 neurological system process
5.99 2.13e-07 GO:0007186 G-protein coupled receptor protein signaling pathway
4.82 1.15e-06 GO:0007267 cell-cell signaling
5.79 2.92e-05 GO:0055082 cellular chemical homeostasis
3.80 3.33e-05 GO:0007154 cell communication
2.12 8.59e-05 GO:0023052 signaling
5.60 1.30e-04 GO:0006873 cellular ion homeostasis
10.37 1.41e-04 GO:0031644 regulation of neurological system process
6.53 2.01e-04 GO:0007610 behavior
4.52 2.95e-04 GO:0048878 chemical homeostasis
5.17 3.42e-04 GO:0050801 ion homeostasis
4.78 3.51e-04 GO:0019725 cellular homeostasis
10.18 7.92e-04 GO:0051969 regulation of transmission of nerve impulse
5.09 1.05e-03 GO:0046903 secretion
1.77 1.30e-03 GO:0032501 multicellular organismal process
7.64 1.84e-03 GO:0055074 calcium ion homeostasis
21.31 2.29e-03 GO:0051952 regulation of amine transport
7.36 2.50e-03 GO:0072507 divalent inorganic cation homeostasis
5.68 2.52e-03 GO:0055080 cation homeostasis
10.42 3.25e-03 GO:0003001 generation of a signal involved in cell-cell signaling
10.42 3.25e-03 GO:0023061 signal release
6.03 4.22e-03 GO:0055065 metal ion homeostasis
28.67 6.79e-03 GO:0014073 response to tropane
28.67 6.79e-03 GO:0042220 response to cocaine
3.37 6.91e-03 GO:0042592 homeostatic process
5.66 7.32e-03 GO:0030003 cellular cation homeostasis
26.28 9.76e-03 GO:0060078 regulation of postsynaptic membrane potential
5.33 1.22e-02 GO:0051046 regulation of secretion
10.88 1.24e-02 GO:0001505 regulation of neurotransmitter levels
7.02 1.25e-02 GO:0006874 cellular calcium ion homeostasis
2.28 1.34e-02 GO:0065008 regulation of biological quality
24.26 1.36e-02 GO:0050433 regulation of catecholamine secretion
6.79 1.59e-02 GO:0072503 cellular divalent inorganic cation homeostasis
23.36 1.59e-02 GO:0045776 negative regulation of blood pressure
6.75 1.65e-02 GO:0003013 circulatory system process
6.75 1.65e-02 GO:0008015 blood circulation
5.09 1.81e-02 GO:0044057 regulation of system process
10.18 1.82e-02 GO:0007626 locomotory behavior
5.62 2.18e-02 GO:0006875 cellular metal ion homeostasis
43.00 2.62e-02 GO:0032225 regulation of synaptic transmission, dopaminergic
9.37 2.90e-02 GO:0006836 neurotransmitter transport
12.72 3.00e-02 GO:0007269 neurotransmitter secretion
9.19 3.24e-02 GO:0008217 regulation of blood pressure
39.42 3.47e-02 GO:0032413 negative regulation of ion transmembrane transporter activity
11.95 4.06e-02 GO:0007631 feeding behavior
36.39 4.50e-02 GO:0051954 positive regulation of amine transport
11.60 4.69e-02 GO:0030534 adult behavior

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
6.53 3.61e-07 GO:0045202 synapse
7.70 4.74e-07 GO:0044456 synapse part
24.53 1.65e-06 GO:0030672 synaptic vesicle membrane
6.17 2.52e-06 GO:0043005 neuron projection
14.85 8.44e-06 GO:0030665 clathrin coated vesicle membrane
14.67 9.26e-06 GO:0008021 synaptic vesicle
10.98 8.88e-05 GO:0030662 coated vesicle membrane
6.70 9.93e-05 GO:0030659 cytoplasmic vesicle membrane
8.88 1.05e-04 GO:0030136 clathrin-coated vesicle
6.48 1.39e-04 GO:0012506 vesicle membrane
1.55 1.61e-04 GO:0016020 membrane
8.31 1.83e-04 GO:0043025 neuronal cell body
8.07 2.33e-04 GO:0044297 cell body
7.25 5.64e-04 GO:0030135 coated vesicle
5.57 6.05e-04 GO:0044433 cytoplasmic vesicle part
3.89 1.85e-03 GO:0030054 cell junction
3.27 1.99e-03 GO:0042995 cell projection
1.58 2.08e-03 GO:0044425 membrane part
3.46 3.57e-03 GO:0016023 cytoplasmic membrane-bounded vesicle
3.39 4.43e-03 GO:0031988 membrane-bounded vesicle
9.56 5.16e-03 GO:0019717 synaptosome
1.76 5.68e-03 GO:0005886 plasma membrane
3.25 7.17e-03 GO:0031410 cytoplasmic vesicle
1.74 8.14e-03 GO:0071944 cell periphery
3.15 1.03e-02 GO:0031982 vesicle
5.85 2.64e-02 GO:0030425 dendrite
1.56 2.85e-02 GO:0031224 intrinsic to membrane
78.83 3.14e-02 GO:0032590 dendrite membrane
1.55 3.59e-02 GO:0016021 integral to membrane
2.89 4.48e-02 GO:0005624 membrane fraction
2.02 4.49e-02 GO:0044459 plasma membrane part
6.40 4.73e-02 GO:0045211 postsynaptic membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
20.13 6.89e-05 GO:0005231 excitatory extracellular ligand-gated ion channel activity
13.15 8.82e-04 GO:0005230 extracellular ligand-gated ion channel activity
36.39 9.56e-03 GO:0016594 glycine binding
2.64 1.25e-02 GO:0005215 transporter activity
105.10 1.68e-02 GO:0001591 dopamine receptor activity, coupled via Gi/Go
7.70 1.85e-02 GO:0043176 amine binding
7.58 2.02e-02 GO:0015276 ligand-gated ion channel activity
7.58 2.02e-02 GO:0022834 ligand-gated channel activity
78.83 3.35e-02 GO:0016933 extracellular-glycine-gated ion channel activity
78.83 3.35e-02 GO:0016934 extracellular-glycine-gated chloride channel activity
22.53 4.28e-02 GO:0005184 neuropeptide hormone activity