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• Mean activities

• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
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Motif ID: REST.p3

Z-value: 2.613

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr9_+_134447795	10.622	NM_020064	BARHL1	BarH-like homeobox 1
chr8_-_145530639	7.313	NM_031309	SCRT1	scratch homolog 1, zinc finger protein (Drosophila)
chr15_+_65904994	7.176	NM_001031807	SKOR1	SKI family transcriptional corepressor 1
chr12_+_46133	5.712	NM_001170738	IQSEC3	IQ motif and Sec7 domain 3
chr10_+_99599984	5.105	NM_001010917	GOLGA7B	golgin A7 family, member B
chr4_+_8633116	4.246	NM_080819	GPR78	G protein-coupled receptor 78
chr4_+_158361185	4.078	NM_000826 NM_001083619 NM_001083620	GRIA2	glutamate receptor, ionotropic, AMPA 2
chr9_+_139153409	3.890	NM_000832 NM_001185090 NM_001185091 NM_007327 NM_021569	GRIN1	glutamate receptor, ionotropic, N-methyl D-aspartate 1
chrX_-_152794592	3.538	NM_000425 NM_001143963 NM_024003	L1CAM	L1 cell adhesion molecule
chr20_+_30019465	3.485	NM_001011718	XKR7	XK, Kell blood group complex subunit-related family, member 7
chr7_+_154943466	3.391	NM_001427	EN2	engrailed homeobox 2
chr20_-_60228665	3.370	NM_007232	HRH3	histamine receptor H3
chr17_-_24357014	3.332	NM_001098635 NM_178860	SEZ6	seizure related 6 homolog (mouse)
chr14_-_73962557	3.290	NM_001105579	TMEM90A	transmembrane protein 90A
chrX_-_152794478	3.173		L1CAM	L1 cell adhesion molecule
chr2_-_27384617	3.071	NM_003353	UCN	urocortin
chr16_+_2959362	3.006		PAQR4	progestin and adipoQ receptor family member IV
chr11_+_627268	2.995	NM_000797	DRD4	dopamine receptor D4
chr5_+_33972247	2.991	NM_016568	RXFP3	relaxin/insulin-like family peptide receptor 3
chr3_+_9720509	2.942	NM_153635	CPNE9	copine family member IX
chr16_+_2959342	2.903	NM_152341	PAQR4	progestin and adipoQ receptor family member IV
chr11_+_22316242	2.692	NM_020346	SLC17A6	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr19_-_3922089	2.514		DAPK3	death-associated protein kinase 3
chr19_-_3922032	2.492		DAPK3	death-associated protein kinase 3
chr14_+_92459197	2.465	NM_001275	CHGA	chromogranin A (parathyroid secretory protein 1)
chr9_-_138236775	2.252	NM_178138	LHX3	LIM homeobox 3
chr20_+_44091265	2.208		SLC12A5	solute carrier family 12 (potassium/chloride transporter), member 5
chr1_+_152806874	2.195	NM_000748	CHRNB2	cholinergic receptor, nicotinic, beta 2 (neuronal)
chrX_-_47364039	2.175
chr8_-_145723209	2.156	NM_001024678	LRRC24	leucine rich repeat containing 24
chrX_-_47364173	2.151	NM_006950 NM_133499	SYN1	synapsin I
chr1_+_152806924	2.122		CHRNB2	cholinergic receptor, nicotinic, beta 2 (neuronal)
chr14_-_104142125	2.120	NM_207379	TMEM179	transmembrane protein 179
chr7_-_19778928	2.107	NM_152774	TMEM196	transmembrane protein 196
chr20_+_44091219	2.084	NM_020708	SLC12A5	solute carrier family 12 (potassium/chloride transporter), member 5
chr12_-_3472245	2.053		LOC100129223	hypothetical LOC100129223
chr17_+_1120607	2.050	NM_001164405	BHLHA9	basic helix-loop-helix family, member a9
chr1_-_173979292	1.897	NM_003285	TNR	tenascin R (restrictin, janusin)
chr14_+_92459244	1.887		CHGA	chromogranin A (parathyroid secretory protein 1)
chr7_+_8439762	1.841		NXPH1	neurexophilin 1
chr7_+_8440541	1.827		NXPH1	neurexophilin 1
chr5_-_175969697	1.786	NM_052899	GPRIN1	G protein regulated inducer of neurite outgrowth 1
chr12_+_111714096	1.771		RPH3A	rabphilin 3A homolog (mouse)
chr3_-_188870799	1.697	NM_001048	SST	somatostatin
chr1_+_33124658	1.677	NM_002143	HPCA	hippocalcin
chr11_-_74818685	1.645		KLHL35	kelch-like 35 (Drosophila)
chr19_+_38867273	1.601	NM_022467	CHST8	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
chr12_+_111713931	1.584	NM_001143854 NM_014954	RPH3A	rabphilin 3A homolog (mouse)
chr7_+_8440109	1.569	NM_152745	NXPH1	neurexophilin 1
chr18_-_39111243	1.506	NM_020783	SYT4	synaptotagmin IV
chr6_+_110406890	1.496	NM_005284	GPR6	G protein-coupled receptor 6
chr3_-_115380539	1.495	NM_000796 NM_033663	DRD3	dopamine receptor D3
chr11_+_45863774	1.468	NM_005456	MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1
chr3_+_122109716	1.450	NM_014980	STXBP5L	syntaxin binding protein 5-like
chr11_-_74818858	1.435		KLHL35	kelch-like 35 (Drosophila)
chr8_+_57520915	1.343
chr7_-_100595552	1.320	NM_003378	VGF	VGF nerve growth factor inducible
chr11_-_123030091	1.301		SCN3B	sodium channel, voltage-gated, type III, beta
chr17_+_77925441	1.263	NM_018949	UTS2R	urotensin 2 receptor
chr2_+_114916368	1.248	NM_020868	DPP10	dipeptidyl-peptidase 10 (non-functional)
chrX_-_48943582	1.240	NM_003179	SYP	synaptophysin
chr19_-_60383280	1.236	NM_003180	SYT5	synaptotagmin V
chr17_+_39741306	1.195	NM_001144825 NM_001144826 NM_006695	RUNDC3A	RUN domain containing 3A
chr16_+_66244314	1.187		RLTPR	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr15_-_81175542	1.175	NM_004644	AP3B2	adaptor-related protein complex 3, beta 2 subunit
chr9_-_73251639	1.173		TRPM3	transient receptor potential cation channel, subfamily M, member 3
chr10_+_26545241	1.164	NM_000818 NM_001134366	GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr19_-_44427446	1.161	NM_172139	IL28B	interleukin 28B (interferon, lambda 3)
chr8_-_57521065	1.139	NM_006211	PENK	proenkephalin
chr11_+_62136788	1.082	NM_000327	ROM1	retinal outer segment membrane protein 1
chr10_+_73225533	1.049	NM_001171933 NM_001171934	CDH23	cadherin-related 23
chr17_-_7159094	1.038	NM_004489	GPS2	G protein pathway suppressor 2
chr19_-_45416043	1.000		TTC9B	tetratricopeptide repeat domain 9B
chr17_-_3248453	0.991	NM_003553	OR1E1	olfactory receptor, family 1, subfamily E, member 1
chr11_-_125278296	0.989	NM_031307	PUS3	pseudouridylate synthase 3
chr6_+_35881048	0.987	NM_182548	LHFPL5	lipoma HMGIC fusion partner-like 5
chr5_-_151284515	0.966	NM_000171 NM_001146040	GLRA1	glycine receptor, alpha 1
chr6_+_158877455	0.961	NM_020823	TMEM181	transmembrane protein 181
chr18_+_55718171	0.936	NM_021127	PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1
chr17_+_27838041	0.906	NM_003885	CDK5R1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr2_+_131230252	0.873	NM_001105194 NM_001105195	FAM123C	family with sequence similarity 123C
chr11_-_27698800	0.860	NM_001143805 NM_001143806 NM_170732	BDNF	brain-derived neurotrophic factor
chr11_-_122357545	0.835	NM_001098169	BSX	brain-specific homeobox
chr10_+_26545599	0.809		GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr11_-_74819165	0.747	NM_001039548	KLHL35	kelch-like 35 (Drosophila)
chr11_-_72170533	0.732		STARD10	StAR-related lipid transfer (START) domain containing 10
chr5_+_175231098	0.690	NM_001008220	CPLX2	complexin 2
chr1_-_239587090	0.688	NM_002924	RGS7	regulator of G-protein signaling 7
chr20_+_61798512	0.688		TNFRSF6B	tumor necrosis factor receptor superfamily, member 6b, decoy
chr5_+_175231170	0.675
chr19_-_45416112	0.641	NM_152479	TTC9B	tetratricopeptide repeat domain 9B
chr5_+_175231210	0.640		CPLX2	complexin 2
chr19_+_51804260	0.628		CALM3	calmodulin 3 (phosphorylase kinase, delta)
chr20_+_61798446	0.623	NM_003823	TNFRSF6B	tumor necrosis factor receptor superfamily, member 6b, decoy
chr19_+_45728207	0.592	NM_025213	SPTBN4	spectrin, beta, non-erythrocytic 4
chr6_+_25760352	0.583	NM_006998	SCGN	secretagogin, EF-hand calcium binding protein
chr19_+_4720144	0.552		C19orf30	chromosome 19 open reading frame 30
chr5_+_71050745	0.532	NM_004291	CARTPT	CART prepropeptide
chr6_+_158877640	0.508		TMEM181	transmembrane protein 181
chr3_+_62279707	0.488		C3orf14	chromosome 3 open reading frame 14
chr17_-_3283884	0.483	NM_003554	OR1E2	olfactory receptor, family 1, subfamily E, member 2
chr19_+_45728270	0.477		SPTBN4	spectrin, beta, non-erythrocytic 4
chr5_-_135729062	0.476	NM_001167576 NM_001167577 NM_020389	TRPC7	transient receptor potential cation channel, subfamily C, member 7
chr6_-_32121784	0.450	NM_032470	TNXB	tenascin XB
chrX_+_152891184	0.441	NM_003492	TMEM187	transmembrane protein 187
chr11_-_1725924	0.419	NM_001170820	LOC402778	CD225 family protein FLJ76511
chr16_+_4948318	0.393	NM_014692	SEC14L5	SEC14-like 5 (S. cerevisiae)
chr11_+_64565118	0.386		SAC3D1	SAC3 domain containing 1
chr3_+_195336631	0.384		HES1	hairy and enhancer of split 1, (Drosophila)
chr16_+_2450081	0.375	NM_025108	C16orf59	chromosome 16 open reading frame 59
chr1_-_239587007	0.373		RGS7	regulator of G-protein signaling 7
chr1_-_102235377	0.356	NM_058170	OLFM3	olfactomedin 3
chr2_+_207215386	0.351	NM_001102659	LOC200726	hCG1657980
chr9_+_116131889	0.341	NM_000608	ORM2	orosomucoid 2
chr2_-_219791638	0.339		ABCB6	ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr11_-_1725662	0.336		LOC402778	CD225 family protein FLJ76511
chr14_-_93829347	0.313	NM_001100607	SERPINA10	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr5_+_175231144	0.313		CPLX2	complexin 2
chr1_-_102234959	0.303		OLFM3	olfactomedin 3
chr20_+_56861430	0.302	NM_001077490 NM_080425	GNAS	GNAS complex locus
chr16_-_2125825	0.286	NM_000296 NM_001009944	PKD1	polycystic kidney disease 1 (autosomal dominant)
chr20_+_35445350	0.281		SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr15_-_70399523	0.262		CELF6	CUGBP, Elav-like family member 6
chr19_-_50429306	0.260	NM_138568	EXOC3L2	exocyst complex component 3-like 2
chr3_+_52787478	0.253	NM_001166434	ITIH1	inter-alpha (globulin) inhibitor H1
chr3_+_195336625	0.232	NM_005524	HES1	hairy and enhancer of split 1, (Drosophila)
chr15_-_70399551	0.231	NM_052840	CELF6	CUGBP, Elav-like family member 6
chr11_-_27677755	0.223	NM_170734	BDNF	brain-derived neurotrophic factor
chr1_+_1836125	0.218	NM_138705	CALML6	calmodulin-like 6
chr8_+_11703368	0.182		FDFT1	farnesyl-diphosphate farnesyltransferase 1
chr9_+_137593420	0.161	NM_001018049 NM_002571	PAEP	progestagen-associated endometrial protein
chr10_-_44200458	0.158	NM_000609 NM_001033886 NM_001178134 NM_199168	CXCL12	chemokine (C-X-C motif) ligand 12
chr8_+_69026895	0.149		PREX2	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr17_-_37022465	0.142	NM_005557	KRT16	keratin 16
chr11_-_6633427	0.131	NM_003737	DCHS1	dachsous 1 (Drosophila)
chr2_-_219791902	0.122	NM_005689	ABCB6	ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr6_+_154402135	0.121	NM_000914 NM_001008503 NM_001008504 NM_001008505 NM_001145282 NM_001145283 NM_001145285 NM_001145286 NM_001145284	OPRM1	opioid receptor, mu 1
chr5_-_70621688	0.103		SMA4	glucuronidase, beta pseudogene
chr4_-_175986952	0.102	NM_001042543 NM_006529	GLRA3	glycine receptor, alpha 3
chr9_-_122852356	0.097	NM_001735	C5	complement component 5
chr19_-_11500912	0.091	NM_001142464 NM_001142465 NM_016581	ECSIT	ECSIT homolog (Drosophila)
chr8_+_69027143	0.090	NM_024870 NM_025170	PREX2	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr17_-_3546236	0.086	NM_002561 NM_175080 NM_175081	P2RX5-TAX1BP3 P2RX5	P2RX5-TAX1BP3 read-through transcript purinergic receptor P2X, ligand-gated ion channel, 5
chr15_-_70399301	0.083	NM_001172684	CELF6	CUGBP, Elav-like family member 6
chr1_+_100777044	0.077		GPR88	G protein-coupled receptor 88
chr19_+_9064854	0.076	NM_001004456	OR1M1	olfactory receptor, family 1, subfamily M, member 1
chr8_+_69027277	0.072		PREX2	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr12_+_6431437	0.069	NM_018009	TAPBPL	TAP binding protein-like
chr12_-_97812633	0.061		ANKS1B	ankyrin repeat and sterile alpha motif domain containing 1B
chr22_-_16636748	0.044	NM_197966	BID	BH3 interacting domain death agonist
chr8_+_80685859	0.035		STMN2	stathmin-like 2
chr19_+_15058790	0.021	NM_001004713	OR1I1	olfactory receptor, family 1, subfamily I, member 1
chr5_-_69917721	0.021		SMA4	glucuronidase, beta pseudogene
chr1_-_33108876	0.019	NM_001171940 NM_153756	FNDC5	fibronectin type III domain containing 5
chr6_+_44346457	0.010	NM_001137560	TMEM151B	transmembrane protein 151B
chr3_-_25680723	0.007	NM_001068	TOP2B	topoisomerase (DNA) II beta 180kDa
chr16_+_67902751	0.006	NM_013245	VPS4A	vacuolar protein sorting 4 homolog A (S. cerevisiae)

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
7.93	4.16e-10	GO:0007268	synaptic transmission
7.06	3.51e-09	GO:0019226	transmission of nerve impulse
7.06	3.51e-09	GO:0035637	multicellular organismal signaling
3.47	2.88e-08	GO:0003008	system process
3.82	5.55e-08	GO:0050877	neurological system process
5.99	2.13e-07	GO:0007186	G-protein coupled receptor protein signaling pathway
4.82	1.15e-06	GO:0007267	cell-cell signaling
5.79	2.92e-05	GO:0055082	cellular chemical homeostasis
3.80	3.33e-05	GO:0007154	cell communication
2.12	8.59e-05	GO:0023052	signaling
5.60	1.30e-04	GO:0006873	cellular ion homeostasis
10.37	1.41e-04	GO:0031644	regulation of neurological system process
6.53	2.01e-04	GO:0007610	behavior
4.52	2.95e-04	GO:0048878	chemical homeostasis
5.17	3.42e-04	GO:0050801	ion homeostasis
4.78	3.51e-04	GO:0019725	cellular homeostasis
10.18	7.92e-04	GO:0051969	regulation of transmission of nerve impulse
5.09	1.05e-03	GO:0046903	secretion
1.77	1.30e-03	GO:0032501	multicellular organismal process
7.64	1.84e-03	GO:0055074	calcium ion homeostasis
21.31	2.29e-03	GO:0051952	regulation of amine transport
7.36	2.50e-03	GO:0072507	divalent inorganic cation homeostasis
5.68	2.52e-03	GO:0055080	cation homeostasis
10.42	3.25e-03	GO:0003001	generation of a signal involved in cell-cell signaling
10.42	3.25e-03	GO:0023061	signal release
6.03	4.22e-03	GO:0055065	metal ion homeostasis
28.67	6.79e-03	GO:0014073	response to tropane
28.67	6.79e-03	GO:0042220	response to cocaine
3.37	6.91e-03	GO:0042592	homeostatic process
5.66	7.32e-03	GO:0030003	cellular cation homeostasis
26.28	9.76e-03	GO:0060078	regulation of postsynaptic membrane potential
5.33	1.22e-02	GO:0051046	regulation of secretion
10.88	1.24e-02	GO:0001505	regulation of neurotransmitter levels
7.02	1.25e-02	GO:0006874	cellular calcium ion homeostasis
2.28	1.34e-02	GO:0065008	regulation of biological quality
24.26	1.36e-02	GO:0050433	regulation of catecholamine secretion
6.79	1.59e-02	GO:0072503	cellular divalent inorganic cation homeostasis
23.36	1.59e-02	GO:0045776	negative regulation of blood pressure
6.75	1.65e-02	GO:0003013	circulatory system process
6.75	1.65e-02	GO:0008015	blood circulation
5.09	1.81e-02	GO:0044057	regulation of system process
10.18	1.82e-02	GO:0007626	locomotory behavior
5.62	2.18e-02	GO:0006875	cellular metal ion homeostasis
43.00	2.62e-02	GO:0032225	regulation of synaptic transmission, dopaminergic
9.37	2.90e-02	GO:0006836	neurotransmitter transport
12.72	3.00e-02	GO:0007269	neurotransmitter secretion
9.19	3.24e-02	GO:0008217	regulation of blood pressure
39.42	3.47e-02	GO:0032413	negative regulation of ion transmembrane transporter activity
11.95	4.06e-02	GO:0007631	feeding behavior
36.39	4.50e-02	GO:0051954	positive regulation of amine transport
11.60	4.69e-02	GO:0030534	adult behavior

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
6.53	3.61e-07	GO:0045202	synapse
7.70	4.74e-07	GO:0044456	synapse part
24.53	1.65e-06	GO:0030672	synaptic vesicle membrane
6.17	2.52e-06	GO:0043005	neuron projection
14.85	8.44e-06	GO:0030665	clathrin coated vesicle membrane
14.67	9.26e-06	GO:0008021	synaptic vesicle
10.98	8.88e-05	GO:0030662	coated vesicle membrane
6.70	9.93e-05	GO:0030659	cytoplasmic vesicle membrane
8.88	1.05e-04	GO:0030136	clathrin-coated vesicle
6.48	1.39e-04	GO:0012506	vesicle membrane
1.55	1.61e-04	GO:0016020	membrane
8.31	1.83e-04	GO:0043025	neuronal cell body
8.07	2.33e-04	GO:0044297	cell body
7.25	5.64e-04	GO:0030135	coated vesicle
5.57	6.05e-04	GO:0044433	cytoplasmic vesicle part
3.89	1.85e-03	GO:0030054	cell junction
3.27	1.99e-03	GO:0042995	cell projection
1.58	2.08e-03	GO:0044425	membrane part
3.46	3.57e-03	GO:0016023	cytoplasmic membrane-bounded vesicle
3.39	4.43e-03	GO:0031988	membrane-bounded vesicle
9.56	5.16e-03	GO:0019717	synaptosome
1.76	5.68e-03	GO:0005886	plasma membrane
3.25	7.17e-03	GO:0031410	cytoplasmic vesicle
1.74	8.14e-03	GO:0071944	cell periphery
3.15	1.03e-02	GO:0031982	vesicle
5.85	2.64e-02	GO:0030425	dendrite
1.56	2.85e-02	GO:0031224	intrinsic to membrane
78.83	3.14e-02	GO:0032590	dendrite membrane
1.55	3.59e-02	GO:0016021	integral to membrane
2.89	4.48e-02	GO:0005624	membrane fraction
2.02	4.49e-02	GO:0044459	plasma membrane part
6.40	4.73e-02	GO:0045211	postsynaptic membrane

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
20.13	6.89e-05	GO:0005231	excitatory extracellular ligand-gated ion channel activity
13.15	8.82e-04	GO:0005230	extracellular ligand-gated ion channel activity
36.39	9.56e-03	GO:0016594	glycine binding
2.64	1.25e-02	GO:0005215	transporter activity
105.10	1.68e-02	GO:0001591	dopamine receptor activity, coupled via Gi/Go
7.70	1.85e-02	GO:0043176	amine binding
7.58	2.02e-02	GO:0015276	ligand-gated ion channel activity
7.58	2.02e-02	GO:0022834	ligand-gated channel activity
78.83	3.35e-02	GO:0016933	extracellular-glycine-gated ion channel activity
78.83	3.35e-02	GO:0016934	extracellular-glycine-gated chloride channel activity
22.53	4.28e-02	GO:0005184	neuropeptide hormone activity