Motif ID: RREB1.p2

Z-value: 4.720


Transcription factors associated with RREB1.p2:

Gene SymbolEntrez IDGene Name
RREB1 6239 ras responsive element binding protein 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RREB1chr6_+_7052798-0.449.2e-02Click!


Activity profile for motif RREB1.p2.

activity profile for motif RREB1.p2


Sorted Z-values histogram for motif RREB1.p2

Sorted Z-values for motif RREB1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RREB1.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_191232653 10.822 NM_033178
NM_012147
NM_001177376
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
 DUX4
DUX2
DUX4L4
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr10_+_135343649 10.235 NM_012147
 DUX2
double homeobox 2
chr10_+_135333667 8.990 NM_033178
NM_012147
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
 DUX4
DUX2
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr10_+_135330357 8.836 NM_033178
NM_012147
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
 DUX4
DUX2
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr4_+_191235959 8.638 NM_001177376
 DUX4L4
double homeobox 4 like 4
chr4_-_809879 8.053 NM_006651
 CPLX1
complexin 1
chr4_+_191239247 7.910 NM_033178
NM_012147
NM_001177376
NM_001127388
NM_001127389
NM_001164467
NM_001127386
 DUX4
DUX2
DUX4L4
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr4_+_191229360 7.730 NM_033178
NM_012147
NM_001177376
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
 DUX4
DUX2
DUX4L4
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr14_+_104244998 7.668 INF2
inverted formin, FH2 and WH2 domain containing
chr4_+_191226073 7.578 NM_012147
NM_001177376
NM_001127388
NM_001127389
NM_001164467
 DUX2
DUX4L4
DUX4L6
DUX4L5
DUX4L3
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
chr1_-_30977931 7.270 LAPTM5
lysosomal protein transmembrane 5
chr19_+_540849 7.194 NM_001194
 HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr2_-_96924582 6.380 NM_001172667
 FAM178B
family with sequence similarity 178, member B
chr4_+_191242540 5.613 NM_033178
NM_012147
NM_001177376
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
 DUX4
DUX2
DUX4L4
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr11_+_56984702 5.324 NM_178570
 RTN4RL2
reticulon 4 receptor-like 2
chr1_+_1066138 5.320


chr20_-_61574259 5.293 NM_004518
NM_172106
NM_172107
NM_172108
NM_172109
 KCNQ2




potassium voltage-gated channel, KQT-like subfamily, member 2




chr21_+_42946719 5.215 NM_001001567
NM_001001568
NM_001001569
NM_001001570
NM_001001571
NM_001001572
NM_001001573
NM_001001574
NM_001001575
NM_001001576
NM_001001577
NM_001001578
NM_001001579
NM_001001580
NM_001001581
NM_001001582
NM_001001583
NM_001001584
NM_001001585
NM_002606
 PDE9A



















phosphodiesterase 9A



















chr2_-_128149112 5.171 NM_001136037
NM_001161403
 LIMS2

LIM and senescent cell antigen-like domains 2

chr1_+_1940605 4.880 NM_000815
 GABRD
gamma-aminobutyric acid (GABA) A receptor, delta

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 126 entries
enrichment   p-value GO term description
3.15 1.09e-02 GO:0071300 cellular response to retinoic acid
3.03 2.29e-02 GO:0071299 cellular response to vitamin A
2.75 2.25e-02 GO:0051925 regulation of calcium ion transport via voltage-gated calcium channel activity
2.30 7.15e-04 GO:0021953 central nervous system neuron differentiation
1.96 2.31e-03 GO:0030799 regulation of cyclic nucleotide metabolic process
1.95 4.98e-02 GO:0045761 regulation of adenylate cyclase activity
1.90 7.43e-04 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
1.89 1.77e-02 GO:0030802 regulation of cyclic nucleotide biosynthetic process
1.89 1.77e-02 GO:0030808 regulation of nucleotide biosynthetic process
1.84 1.68e-04 GO:0045664 regulation of neuron differentiation
1.82 2.28e-03 GO:0030900 forebrain development
1.81 7.41e-03 GO:0006813 potassium ion transport
1.80 9.80e-04 GO:0032582 negative regulation of gene-specific transcription
1.76 2.15e-06 GO:0060284 regulation of cell development
1.75 1.81e-04 GO:0050767 regulation of neurogenesis
1.74 6.34e-03 GO:0007517 muscle organ development
1.71 1.63e-04 GO:0051960 regulation of nervous system development
1.71 4.18e-04 GO:0045596 negative regulation of cell differentiation
1.69 3.48e-04 GO:0061061 muscle structure development
1.66 3.40e-12 GO:0030182 neuron differentiation

Gene overrepresentation in compartment category:

Showing 1 to 13 of 13 entries
enrichment   p-value GO term description
2.12 5.72e-03 GO:0042383 sarcolemma
2.04 3.45e-03 GO:0008076 voltage-gated potassium channel complex
2.04 3.45e-03 GO:0034705 potassium channel complex
2.00 2.60e-05 GO:0034703 cation channel complex
1.75 1.20e-04 GO:0034702 ion channel complex
1.53 2.00e-04 GO:0045202 synapse
1.53 6.24e-03 GO:0044456 synapse part
1.46 3.93e-03 GO:0043005 neuron projection
1.43 2.00e-04 GO:0030054 cell junction
1.26 3.63e-07 GO:0044459 plasma membrane part
1.22 4.98e-02 GO:0031226 intrinsic to plasma membrane
1.13 1.40e-03 GO:0005886 plasma membrane
1.12 3.86e-03 GO:0071944 cell periphery

Gene overrepresentation in function category:

Showing 1 to 20 of 23 entries
enrichment   p-value GO term description
2.11 8.05e-07 GO:0022843 voltage-gated cation channel activity
1.99 1.98e-04 GO:0005267 potassium channel activity
1.96 8.65e-03 GO:0005249 voltage-gated potassium channel activity
1.87 2.06e-05 GO:0005244 voltage-gated ion channel activity
1.87 2.06e-05 GO:0022832 voltage-gated channel activity
1.83 1.89e-07 GO:0005261 cation channel activity
1.75 3.12e-04 GO:0000975 regulatory region DNA binding
1.75 3.12e-04 GO:0001067 regulatory region nucleic acid binding
1.75 3.12e-04 GO:0044212 transcription regulatory region DNA binding
1.75 6.00e-04 GO:0010843 promoter binding
1.73 2.54e-16 GO:0043565 sequence-specific DNA binding
1.63 1.00e-04 GO:0022836 gated channel activity
1.59 1.69e-05 GO:0022838 substrate-specific channel activity
1.58 4.37e-05 GO:0005216 ion channel activity
1.55 6.42e-05 GO:0015267 channel activity
1.55 7.52e-05 GO:0022803 passive transmembrane transporter activity
1.54 4.25e-13 GO:0001071 nucleic acid binding transcription factor activity
1.54 4.25e-13 GO:0003700 sequence-specific DNA binding transcription factor activity
1.54 4.33e-03 GO:0016564 transcription repressor activity
1.52 5.97e-03 GO:0016563 transcription activator activity