Motif ID: RUNX1..3.p2

Z-value: 2.061


Transcription factors associated with RUNX1..3.p2:

Gene SymbolEntrez IDGene Name
RUNX1 861 runt-related transcription factor 1
RUNX2 860 runt-related transcription factor 2
RUNX3 864 runt-related transcription factor 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RUNX3chr1_-_251289510.758.5e-04Click!
RUNX2chr6_+_45404031-0.683.6e-03Click!
RUNX1chr21_-_351812780.332.2e-01Click!


Activity profile for motif RUNX1..3.p2.

activity profile for motif RUNX1..3.p2


Sorted Z-values histogram for motif RUNX1..3.p2

Sorted Z-values for motif RUNX1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RUNX1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_71285992 3.319 H3F3B
H3 histone, family 3B (H3.3B)
chr22_+_21318779 3.008 NM_199127
 GGTLC2
gamma-glutamyltransferase light chain 2
chr1_+_20489998 2.809 NM_001039500
 VWA5B1
von Willebrand factor A domain containing 5B1
chr9_+_129893948 2.740 NM_001006642
 SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chrX_-_131089552 2.676 NM_194277
 FRMD7
FERM domain containing 7
chr1_+_154478574 2.499 NM_199173
 BGLAP
bone gamma-carboxyglutamate (gla) protein
chr16_+_29582069 2.478 NM_003123
 SPN
sialophorin
chr6_-_32121784 2.327 NM_032470
 TNXB
tenascin XB
chrX_-_49008115 2.202 NM_001114377
NM_014009
 FOXP3

forkhead box P3

chr1_+_207995999 2.136 NM_025228
 TRAF3IP3
TRAF3 interacting protein 3
chr22_+_20101661 2.134 NM_015094
 HIC2
hypermethylated in cancer 2
chrX_-_48655978 2.114 PIM2
pim-2 oncogene
chr22_+_17337970 2.037 DGCR5
DiGeorge syndrome critical region gene 5 (non-protein coding)
chr1_+_110456584 1.988 NM_203412
 UBL4B
ubiquitin-like 4B
chr5_-_88155360 1.982 NM_001193348
NM_001193349
 MEF2C

myocyte enhancer factor 2C

chr17_+_23818922 1.978


chr22_-_18635614 1.978 NM_023004
 RTN4R
reticulon 4 receptor
chr16_+_29582065 1.940 SPN
sialophorin
chr20_-_23915431 1.930 NM_178312
 GGTLC1
gamma-glutamyltransferase light chain 1
chr1_-_25164061 1.898 NM_001031680
 RUNX3
runt-related transcription factor 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 18 of 18 entries
enrichment   p-value GO term description
1.98 2.39e-02 GO:2000145 regulation of cell motility
1.96 3.97e-02 GO:0030334 regulation of cell migration
1.82 7.50e-04 GO:0001775 cell activation
1.66 4.34e-02 GO:0008284 positive regulation of cell proliferation
1.62 2.16e-03 GO:0006955 immune response
1.51 2.54e-04 GO:0002376 immune system process
1.36 8.36e-03 GO:0007166 cell surface receptor linked signaling pathway
1.35 8.56e-03 GO:0048583 regulation of response to stimulus
1.33 1.48e-06 GO:0007165 signal transduction
1.32 4.09e-07 GO:0023052 signaling
1.32 9.07e-03 GO:0065008 regulation of biological quality
1.26 4.60e-02 GO:0048518 positive regulation of biological process
1.24 4.39e-04 GO:0051716 cellular response to stimulus
1.22 1.30e-06 GO:0050896 response to stimulus
1.17 3.27e-02 GO:0032501 multicellular organismal process
1.14 3.97e-02 GO:0050794 regulation of cellular process
1.13 9.01e-03 GO:0065007 biological regulation
1.13 2.02e-02 GO:0050789 regulation of biological process

Gene overrepresentation in compartment category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
2.16 4.03e-02 GO:0009897 external side of plasma membrane
1.76 1.78e-07 GO:0005615 extracellular space
1.60 4.33e-06 GO:0044421 extracellular region part
1.49 6.23e-05 GO:0031226 intrinsic to plasma membrane
1.48 1.38e-04 GO:0005887 integral to plasma membrane
1.40 2.29e-06 GO:0044459 plasma membrane part
1.39 9.66e-06 GO:0005576 extracellular region
1.25 1.69e-05 GO:0005886 plasma membrane
1.23 7.36e-05 GO:0071944 cell periphery

Gene overrepresentation in function category:

Showing 1 to 3 of 3 entries
enrichment   p-value GO term description
9.21 2.37e-02 GO:0003840 gamma-glutamyltransferase activity
2.03 3.61e-02 GO:0005126 cytokine receptor binding
1.43 1.93e-02 GO:0005102 receptor binding