Motif ID: RUNX1..3.p2

Z-value: 2.061


Transcription factors associated with RUNX1..3.p2:

Gene SymbolEntrez IDGene Name
RUNX1 861 runt-related transcription factor 1
RUNX2 860 runt-related transcription factor 2
RUNX3 864 runt-related transcription factor 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RUNX3chr1_-_251289510.758.5e-04Click!
RUNX2chr6_+_45404031-0.683.6e-03Click!
RUNX1chr21_-_351812780.332.2e-01Click!


Activity profile for motif RUNX1..3.p2.

activity profile for motif RUNX1..3.p2


Sorted Z-values histogram for motif RUNX1..3.p2

Sorted Z-values for motif RUNX1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RUNX1..3.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_71285992 3.319 H3F3B
H3 histone, family 3B (H3.3B)
chr22_+_21318779 3.008 NM_199127
GGTLC2
gamma-glutamyltransferase light chain 2
chr1_+_20489998 2.809 NM_001039500
VWA5B1
von Willebrand factor A domain containing 5B1
chr9_+_129893948 2.740 NM_001006642
SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chrX_-_131089552 2.676 NM_194277
FRMD7
FERM domain containing 7
chr1_+_154478574 2.499 NM_199173
BGLAP
bone gamma-carboxyglutamate (gla) protein
chr16_+_29582069 2.478 NM_003123
SPN
sialophorin
chr6_-_32121784 2.327 NM_032470
TNXB
tenascin XB
chrX_-_49008115 2.202 NM_001114377
NM_014009
FOXP3

forkhead box P3

chr1_+_207995999 2.136 NM_025228
TRAF3IP3
TRAF3 interacting protein 3
chr22_+_20101661 2.134 NM_015094
HIC2
hypermethylated in cancer 2
chrX_-_48655978 2.114 PIM2
pim-2 oncogene
chr22_+_17337970 2.037 DGCR5
DiGeorge syndrome critical region gene 5 (non-protein coding)
chr1_+_110456584 1.988 NM_203412
UBL4B
ubiquitin-like 4B
chr5_-_88155360 1.982 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr17_+_23818922 1.978


chr22_-_18635614 1.978 NM_023004
RTN4R
reticulon 4 receptor
chr16_+_29582065 1.940 SPN
sialophorin
chr20_-_23915431 1.930 NM_178312
GGTLC1
gamma-glutamyltransferase light chain 1
chr1_-_25164061 1.898 NM_001031680
RUNX3
runt-related transcription factor 3
chrX_+_71280758 1.836 NM_207422
FLJ44635
TPT1-like protein
chr3_+_46894239 1.745 NM_000316
PTH1R
parathyroid hormone 1 receptor
chr16_+_29942155 1.723 NM_001109659
NM_001109660
C16orf92

chromosome 16 open reading frame 92

chr22_+_20326591 1.716 SDF2L1
stromal cell-derived factor 2-like 1
chr1_-_24342158 1.714 NM_021258
IL22RA1
interleukin 22 receptor, alpha 1
chr11_+_1846478 1.714 NM_001013253
LSP1
lymphocyte-specific protein 1
chr22_+_20326541 1.688 NM_022044
SDF2L1
stromal cell-derived factor 2-like 1
chr22_+_20326572 1.687 SDF2L1
stromal cell-derived factor 2-like 1
chr22_+_20326615 1.683 SDF2L1
stromal cell-derived factor 2-like 1
chr12_+_52696908 1.680 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr2_+_127892459 1.664 NM_000312
PROC
protein C (inactivator of coagulation factors Va and VIIIa)
chr13_+_112789669 1.630 MCF2L
MCF.2 cell line derived transforming sequence-like
chr1_-_16812274 1.597 NM_017940
NBPF1
neuroblastoma breakpoint family, member 1
chr22_+_21484240 1.589


chr4_-_1185144 1.574 LOC100130872
hypothetical LOC100130872
chr8_+_143542378 1.558 NM_001702
BAI1
brain-specific angiogenesis inhibitor 1
chr1_+_153557263 1.556 NM_001105203
NM_001105204
RUSC1

RUN and SH3 domain containing 1

chr1_+_22176004 1.555 NM_007352
CELA3A
CELA3B
chymotrypsin-like elastase family, member 3A
chymotrypsin-like elastase family, member 3B
chr7_+_150376537 1.532 NM_004769
NM_020321
NM_020322
ACCN3


amiloride-sensitive cation channel 3


chr1_+_234624266 1.495 NM_145861
EDARADD
EDAR-associated death domain
chr2_+_85774924 1.476 NM_006433
NM_012483
GNLY

granulysin

chr22_+_21552897 1.461 LOC100290481
immunoglobulin lambda light chain-like
chrX_-_100015783 1.451 NM_007052
NM_013955
NOX1

NADPH oxidase 1

chr6_+_167624792 1.421 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr15_+_19883745 1.419 NM_001005241
OR4N4
olfactory receptor, family 4, subfamily N, member 4
chr19_+_59657440 1.414


chr6_+_155579788 1.398 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr6_+_37030186 1.375 NM_153370
PI16
peptidase inhibitor 16
chr20_+_61394982 1.366 NM_020882
COL20A1
collagen, type XX, alpha 1
chr7_+_116447499 1.350 ST7
suppression of tumorigenicity 7
chr11_-_404975 1.349 NM_001135054
SIGIRR
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
chr4_-_8180278 1.334 ABLIM2
actin binding LIM protein family, member 2
chr8_+_1940282 1.332 KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr8_-_134141586 1.321 NM_006748
SLA
Src-like-adaptor
chr17_+_31112028 1.317 NM_145272
C17orf50
chromosome 17 open reading frame 50
chr3_-_152403636 1.316 NM_013308
GPR171
G protein-coupled receptor 171
chr17_-_53961709 1.315 NM_004574
SEPT4
septin 4
chr21_-_35153664 1.290 RUNX1
runt-related transcription factor 1
chr1_+_9222489 1.271 H6PD
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
chr12_+_47658502 1.269 NM_005430
WNT1
wingless-type MMTV integration site family, member 1
chr20_-_61669550 1.264 NM_033405
PRIC285
peroxisomal proliferator-activated receptor A interacting complex 285
chr6_-_31853027 1.262 NM_025258
C6orf27
chromosome 6 open reading frame 27
chr22_+_21384862 1.227 IGLV3-21
IGLJ3
IGLC1
immunoglobulin lambda variable 3-21
immunoglobulin lambda joining 3
immunoglobulin lambda constant 1 (Mcg marker)
chr7_+_116447527 1.219 ST7
suppression of tumorigenicity 7
chrX_+_46967360 1.212 NM_001170460
CDK16
cyclin-dependent kinase 16
chr7_+_150321771 1.208 NM_001160109
NM_001160110
NM_001160111
NOS3


nitric oxide synthase 3 (endothelial cell)


chr1_+_35104120 1.207


chr17_+_45598363 1.203 NM_000023
NM_001135697
SGCA

sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)

chr17_-_3442871 1.202 NM_080706
TRPV1
transient receptor potential cation channel, subfamily V, member 1
chr2_-_26554413 1.183 NM_004802
NM_194322
NM_194323
OTOF


otoferlin


chr8_+_21956335 1.181 NM_003867
FGF17
fibroblast growth factor 17
chr2_+_127892489 1.167 PROC
protein C (inactivator of coagulation factors Va and VIIIa)
chr19_+_55985483 1.150 NM_033068
ACPT
acid phosphatase, testicular
chr11_+_63864263 1.135 NM_032251
CCDC88B
coiled-coil domain containing 88B
chr7_+_2518688 1.132 NM_001166355
LFNG
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr7_-_27171600 1.130 HOXA9
homeobox A9
chr10_+_70517823 1.122 NM_002727
SRGN
serglycin
chr19_-_60458915 1.083 PPP6R1
protein phosphatase 6, regulatory subunit 1
chr2_+_96566190 1.079 NM_212481
ARID5A
AT rich interactive domain 5A (MRF1-like)
chr1_+_22200735 1.075 NM_005747
CELA3A
chymotrypsin-like elastase family, member 3A
chr5_+_176807931 1.070 NM_001174102
PRR7
proline rich 7 (synaptic)
chr11_+_118710424 1.067 NM_032015
RNF26
ring finger protein 26
chr5_+_149977398 1.063 NM_001166209
SYNPO
synaptopodin
chr5_+_131437383 1.061 NM_000758
CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr17_-_1037312 1.047 NM_001159746
ABR
active BCR-related gene
chr7_+_129771865 1.039 NM_001127441
NM_001127442
NM_080385
CPA5


carboxypeptidase A5


chr12_+_52697160 1.030 HOXC5
HOXC6
homeobox C5
homeobox C6
chr9_-_94206648 1.025 NM_014057
NM_033014
OGN

osteoglycin

chr16_+_3642940 1.018 NM_005223
DNASE1
deoxyribonuclease I
chr16_+_65868913 1.006 NM_015432
PLEKHG4
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr22_-_41672990 1.001 NM_007229
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr16_-_65510230 0.996 NM_004062
CDH16
cadherin 16, KSP-cadherin
chr19_+_5641307 0.987 RPL36
ribosomal protein L36
chrX_+_106057984 0.971 CLDN2
claudin 2
chr4_+_89115862 0.966 SPP1
secreted phosphoprotein 1
chr5_+_149960820 0.962 NM_001166208
SYNPO
synaptopodin
chr6_-_86407875 0.958 NM_001159675
NM_001159676
SYNCRIP

synaptotagmin binding, cytoplasmic RNA interacting protein

chr13_+_113369470 0.952 NM_002929
GRK1
G protein-coupled receptor kinase 1
chr10_+_70517863 0.946 SRGN
serglycin
chr9_-_129580732 0.942 NM_170600
SH2D3C
SH2 domain containing 3C
chr3_-_10522267 0.942 NM_001001331
NM_001683
ATP2B2

ATPase, Ca++ transporting, plasma membrane 2

chr22_+_20350272 0.936 NM_014337
NM_148175
NM_148176
PPIL2


peptidylprolyl isomerase (cyclophilin)-like 2


chrX_-_54226364 0.935 NM_017848
NM_198456
FAM120C

family with sequence similarity 120C

chr4_-_153820535 0.928 NM_152680
TMEM154
transmembrane protein 154
chr11_+_65403859 0.926 NM_001335
CTSW
cathepsin W
chr1_+_34997928 0.924 NM_153212
GJB4
gap junction protein, beta 4, 30.3kDa
chr1_-_205012348 0.922 NM_000572
IL10
interleukin 10
chr17_+_21249040 0.920 NM_001194958
KCNJ18
potassium inwardly-rectifying channel, subfamily J, member 18
chr5_-_76970129 0.906 OTP
orthopedia homeobox
chr1_-_171441234 0.904 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr22_-_28972683 0.903 NM_002309
LIF
leukemia inhibitory factor (cholinergic differentiation factor)
chr12_-_109842736 0.897 NM_000432
MYL2
myosin, light chain 2, regulatory, cardiac, slow
chr11_-_6600385 0.897 DCHS1
dachsous 1 (Drosophila)
chr19_+_5641270 0.893 NM_033643
RPL36
ribosomal protein L36
chrX_+_21960841 0.889 NM_000444
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr17_+_77910411 0.883 NM_207459
TEX19
testis expressed 19
chr7_-_126679540 0.873 NM_001127323
GRM8
glutamate receptor, metabotropic 8
chr5_-_111119846 0.873 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr6_+_158653679 0.873 NM_001007466
NM_020245
TULP4

tubby like protein 4

chr1_+_205068844 0.873 NM_013371
IL19
interleukin 19
chr11_-_31782169 0.872 PAX6
paired box 6
chr17_-_45617899 0.863 COL1A1
collagen, type I, alpha 1
chr1_+_151442542 0.859 NM_001010857
LELP1
late cornified envelope-like proline-rich 1
chr15_-_53440069 0.857 CCPG1
cell cycle progression 1
chr19_-_46504831 0.855


chr10_-_48036698 0.854 NM_016204
GDF2
growth differentiation factor 2
chr21_+_43024936 0.849 PDE9A
phosphodiesterase 9A
chr15_+_39918302 0.846 NM_001114633
PLA2G4B
phospholipase A2, group IVB (cytosolic)
chrX_-_77801480 0.845 NM_152694
ZCCHC5
zinc finger, CCHC domain containing 5
chr3_+_46594079 0.844 NM_003212
TDGF1
teratocarcinoma-derived growth factor 1
chr1_+_32485404 0.843 NM_032648
FAM167B
family with sequence similarity 167, member B
chr19_-_50355247 0.843 NM_198478
NKPD1
NTPase, KAP family P-loop domain containing 1
chr1_+_199130571 0.841 NM_001142569
C1orf106
chromosome 1 open reading frame 106
chr17_-_77512346 0.841 NM_178493
NOTUM
notum pectinacetylesterase homolog (Drosophila)
chr17_+_71141108 0.840 NM_001162995
LOC643008
hypothetical protein LOC643008
chr7_+_120752656 0.836 NM_016087
WNT16
wingless-type MMTV integration site family, member 16
chr2_+_241456834 0.832 NM_000030
AGXT
alanine-glyoxylate aminotransferase
chr11_-_66961709 0.826 NM_005608
PTPRCAP
protein tyrosine phosphatase, receptor type, C-associated protein
chr1_+_196874839 0.819 PTPRC
protein tyrosine phosphatase, receptor type, C
chrX_+_54963953 0.818 NM_001039705
NM_016157
NM_177556
TRO


trophinin


chr12_-_101396459 0.818 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr19_+_55164668 0.817 SIGLEC16
sialic acid binding Ig-like lectin 16 (gene/pseudogene)
chr1_+_19807168 0.817


chrX_-_19727828 0.814 NM_001024666
SH3KBP1
SH3-domain kinase binding protein 1
chr12_+_48443232 0.810 TMBIM6
transmembrane BAX inhibitor motif containing 6
chr19_+_56337368 0.810 NM_014385
NM_016543
SIGLEC7

sialic acid binding Ig-like lectin 7

chr5_-_76970264 0.806 NM_032109
OTP
orthopedia homeobox
chr1_+_158317967 0.803 NM_004983
KCNJ9
potassium inwardly-rectifying channel, subfamily J, member 9
chr3_-_71376919 0.802 FOXP1
forkhead box P1
chr12_+_103677388 0.802 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr1_-_199613427 0.797 NM_000364
NM_001001430
NM_001001431
NM_001001432
TNNT2



troponin T type 2 (cardiac)



chr11_+_6368213 0.795 NM_000543
NM_001007593
SMPD1

sphingomyelin phosphodiesterase 1, acid lysosomal

chr9_+_94749421 0.794 NM_001083536
FGD3
FYVE, RhoGEF and PH domain containing 3
chr20_+_42777298 0.792 NM_003881
WISP2
WNT1 inducible signaling pathway protein 2
chr1_+_32489426 0.790 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chrX_+_71047344 0.787 NM_001013627
NHSL2
NHS-like 2
chr4_+_636965 0.785 NM_001145292
PDE6B
phosphodiesterase 6B, cGMP-specific, rod, beta
chr4_+_89115892 0.785 SPP1
secreted phosphoprotein 1
chr3_-_195571748 0.783 NM_001135057
NM_130830
LRRC15

leucine rich repeat containing 15

chr17_-_40401138 0.779 NM_006688
C1QL1
complement component 1, q subcomponent-like 1
chr12_-_113330574 0.779 NM_000192
NM_080717
TBX5

T-box 5

chr21_-_35343448 0.777 RUNX1
runt-related transcription factor 1
chr16_+_29581783 0.775 NM_001030288
SPN
sialophorin
chrX_+_48427103 0.772 NM_000377
WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr1_+_108794426 0.772 NM_001143987
NM_001143988
NBPF4
NBPF6

neuroblastoma breakpoint family, member 4
neuroblastoma breakpoint family, member 6

chr9_-_94226380 0.768 NM_005014
OMD
osteomodulin
chr1_-_205161821 0.767 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr10_-_64698831 0.766 NM_004241
JMJD1C
jumonji domain containing 1C
chr17_+_76623540 0.763 NM_001144888
NM_006340
NM_017450
NM_017451
BAIAP2



BAI1-associated protein 2



chr17_+_77528699 0.761 NM_024083
ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr15_+_73281249 0.760 NM_015492
C15orf39
chromosome 15 open reading frame 39
chr7_-_149631001 0.760 NM_001164459
ACTR3C
ARP3 actin-related protein 3 homolog C (yeast)
chr19_+_40474867 0.759 NM_002361
NM_080600
MAG

myelin associated glycoprotein

chr11_+_71388619 0.754 NM_001145055
IL18BP
interleukin 18 binding protein
chr11_-_2907169 0.753 NM_003311
PHLDA2
pleckstrin homology-like domain, family A, member 2
chr1_+_968522 0.752 AGRN
agrin
chr4_+_89115825 0.752 NM_000582
NM_001040058
NM_001040060
SPP1


secreted phosphoprotein 1


chr3_-_188936941 0.751 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chr1_+_204710453 0.749 IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr20_+_42776888 0.748 WISP2
WNT1 inducible signaling pathway protein 2
chr16_+_28413421 0.747 NM_018690
APOBR
apolipoprotein B receptor
chr15_+_73281288 0.743 C15orf39
chromosome 15 open reading frame 39
chr6_+_31651319 0.743 NM_000594
TNF
tumor necrosis factor
chr22_+_19248733 0.742 MED15
mediator complex subunit 15
chr14_+_75058591 0.741 BATF
basic leucine zipper transcription factor, ATF-like
chr19_+_59297953 0.741 NM_004542
NDUFA3
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
chr22_-_17798998 0.740 HIRA
HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
chr6_-_10527772 0.739 NM_001042425
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr17_-_1478293 0.737 SLC43A2
solute carrier family 43, member 2
chr1_+_20269239 0.734 NM_000929
PLA2G5
phospholipase A2, group V
chr16_+_28797309 0.733 NM_004320
NM_173201
ATP2A1

ATPase, Ca++ transporting, cardiac muscle, fast twitch 1

chr12_-_69317441 0.732 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr11_-_119499188 0.728 TRIM29
tripartite motif containing 29
chr7_+_5598964 0.725 FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr5_-_148738980 0.722 NM_014443
IL17B
interleukin 17B
chr19_+_531666 0.721 BSG
basigin (Ok blood group)
chr15_+_73281286 0.721 C15orf39
chromosome 15 open reading frame 39
chr8_+_22900863 0.721 NM_001160036
RHOBTB2
Rho-related BTB domain containing 2
chrX_-_152889815 0.713 NM_005334
HCFC1
host cell factor C1 (VP16-accessory protein)
chrX_-_19727775 0.713 SH3KBP1
SH3-domain kinase binding protein 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.32 4.09e-07 GO:0023052 signaling
1.22 1.30e-06 GO:0050896 response to stimulus
1.33 1.48e-06 GO:0007165 signal transduction
1.51 2.54e-04 GO:0002376 immune system process
1.24 4.39e-04 GO:0051716 cellular response to stimulus
1.82 7.50e-04 GO:0001775 cell activation
1.62 2.16e-03 GO:0006955 immune response
1.36 8.36e-03 GO:0007166 cell surface receptor linked signaling pathway
1.35 8.56e-03 GO:0048583 regulation of response to stimulus
1.13 9.01e-03 GO:0065007 biological regulation
1.32 9.07e-03 GO:0065008 regulation of biological quality
1.13 2.02e-02 GO:0050789 regulation of biological process
1.98 2.39e-02 GO:2000145 regulation of cell motility
1.17 3.27e-02 GO:0032501 multicellular organismal process
1.14 3.97e-02 GO:0050794 regulation of cellular process
1.96 3.97e-02 GO:0030334 regulation of cell migration
1.66 4.34e-02 GO:0008284 positive regulation of cell proliferation
1.26 4.60e-02 GO:0048518 positive regulation of biological process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.76 1.78e-07 GO:0005615 extracellular space
1.40 2.29e-06 GO:0044459 plasma membrane part
1.60 4.33e-06 GO:0044421 extracellular region part
1.39 9.66e-06 GO:0005576 extracellular region
1.25 1.69e-05 GO:0005886 plasma membrane
1.49 6.23e-05 GO:0031226 intrinsic to plasma membrane
1.23 7.36e-05 GO:0071944 cell periphery
1.48 1.38e-04 GO:0005887 integral to plasma membrane
2.16 4.03e-02 GO:0009897 external side of plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.43 1.93e-02 GO:0005102 receptor binding
9.21 2.37e-02 GO:0003840 gamma-glutamyltransferase activity
2.03 3.61e-02 GO:0005126 cytokine receptor binding