ISMARA results: SMAD1..7,9.p2

Motif ID: SMAD1..7,9.p2

Z-value: 4.325

Transcription factors associated with SMAD1..7,9.p2:

Gene Symbol	Entrez ID	Gene Name
SMAD1	4086	SMAD family member 1
SMAD2	4087	SMAD family member 2
SMAD3	4088	SMAD family member 3
SMAD4	4089	SMAD family member 4
SMAD5	4090	SMAD family member 5
SMAD6	4091	SMAD family member 6
SMAD7	4092	SMAD family member 7
SMAD9	4093	SMAD family member 9

Activity-expression correlation:

Gene	Promoter	Pearson	P-value	Plot
SMAD4	chr18_+_46810598	-0.72	1.7e-03	Click!
SMAD5	chr5_+_135496421	-0.70	2.3e-03	Click!
SMAD1	chr4_+_146623405	-0.62	1.0e-02	Click!
SMAD3	chr15_+_65245546	0.52	3.9e-02	Click!
SMAD7	chr18_-_44729700	0.51	4.4e-02	Click!
SMAD6	chr15_+_64781723	0.36	1.7e-01	Click!
SMAD2	chr18_-_43711452	-0.35	1.8e-01	Click!
SMAD9	chr13_-_36392370	0.30	2.5e-01	Click!

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Showing 1 to 20 of 200 entries

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr10_+_135343649	7.054	NM_012147	DUX2	double homeobox 2
chr10_+_135333667	7.004	NM_033178 NM_012147 NM_001127387 NM_001127388 NM_001127389 NM_001164467 NM_001127386	DUX4 DUX2 DUX4L7 DUX4L6 DUX4L5 DUX4L3 DUX4L2	double homeobox 4 double homeobox 2 double homeobox 4 like 7 double homeobox 4 like 6 double homeobox 4 like 5 double homeobox 4 like 3 double homeobox 4 like 2
chr4_+_191239247	6.665	NM_033178 NM_012147 NM_001177376 NM_001127388 NM_001127389 NM_001164467 NM_001127386	DUX4 DUX2 DUX4L4 DUX4L6 DUX4L5 DUX4L3 DUX4L2	double homeobox 4 double homeobox 2 double homeobox 4 like 4 double homeobox 4 like 6 double homeobox 4 like 5 double homeobox 4 like 3 double homeobox 4 like 2
chr4_+_191226073	6.296	NM_012147 NM_001177376 NM_001127388 NM_001127389 NM_001164467	DUX2 DUX4L4 DUX4L6 DUX4L5 DUX4L3	double homeobox 2 double homeobox 4 like 4 double homeobox 4 like 6 double homeobox 4 like 5 double homeobox 4 like 3
chr10_+_135330357	6.228	NM_033178 NM_012147 NM_001127387 NM_001127388 NM_001127389 NM_001164467 NM_001127386	DUX4 DUX2 DUX4L7 DUX4L6 DUX4L5 DUX4L3 DUX4L2	double homeobox 4 double homeobox 2 double homeobox 4 like 7 double homeobox 4 like 6 double homeobox 4 like 5 double homeobox 4 like 3 double homeobox 4 like 2
chr4_+_191232653	5.968	NM_033178 NM_012147 NM_001177376 NM_001127387 NM_001127388 NM_001127389 NM_001164467 NM_001127386	DUX4 DUX2 DUX4L4 DUX4L7 DUX4L6 DUX4L5 DUX4L3 DUX4L2	double homeobox 4 double homeobox 2 double homeobox 4 like 4 double homeobox 4 like 7 double homeobox 4 like 6 double homeobox 4 like 5 double homeobox 4 like 3 double homeobox 4 like 2
chr4_+_191235959	5.914	NM_001177376	DUX4L4	double homeobox 4 like 4
chrX_+_110226030	5.303	NM_002578	PAK3	p21 protein (Cdc42/Rac)-activated kinase 3
chr16_+_56219802	5.072	NM_001145771 NM_001145772 NM_001145773 NM_201524 NM_201525	GPR56	G protein-coupled receptor 56
chr11_+_47564805	4.961	NM_001164379	FAM180B	family with sequence similarity 180, member B
chr4_+_191229360	4.837	NM_033178 NM_012147 NM_001177376 NM_001127387 NM_001127388 NM_001127389 NM_001164467 NM_001127386	DUX4 DUX2 DUX4L4 DUX4L7 DUX4L6 DUX4L5 DUX4L3 DUX4L2	double homeobox 4 double homeobox 2 double homeobox 4 like 4 double homeobox 4 like 7 double homeobox 4 like 6 double homeobox 4 like 5 double homeobox 4 like 3 double homeobox 4 like 2
chr9_-_139183675	4.515
chr10_-_102880892	4.513	NM_001085398	TLX1NB	TLX1 neighbor
chrX_+_152682772	4.504	NM_001163257 NM_005393	PLXNB3	plexin B3
chr4_+_191242540	4.333	NM_033178 NM_012147 NM_001177376 NM_001127387 NM_001127388 NM_001127389 NM_001164467 NM_001127386	DUX4 DUX2 DUX4L4 DUX4L7 DUX4L6 DUX4L5 DUX4L3 DUX4L2	double homeobox 4 double homeobox 2 double homeobox 4 like 4 double homeobox 4 like 7 double homeobox 4 like 6 double homeobox 4 like 5 double homeobox 4 like 3 double homeobox 4 like 2
chr19_+_2200112	4.241	NM_000479	AMH	anti-Mullerian hormone
chr17_+_19377732	4.221	NM_018242	SLC47A1	solute carrier family 47, member 1
chr12_+_55896844	4.094	NM_007224	NXPH4	neurexophilin 4
chr1_+_15145001	4.081	NM_001017999	KAZN	kazrin, periplakin interacting protein
chr8_+_143542378	3.934	NM_001702	BAI1	brain-specific angiogenesis inhibitor 1

Gene Ontology Analysis

Gene overrepresentation in process category:

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enrichment	p-value	GO term	description
2.53	2.71e-04	GO:0045761	regulation of adenylate cyclase activity
2.51	4.02e-03	GO:0051048	negative regulation of secretion
2.47	4.90e-04	GO:0031279	regulation of cyclase activity
2.42	8.67e-04	GO:0051339	regulation of lyase activity
2.37	5.19e-04	GO:0030817	regulation of cAMP biosynthetic process
2.35	6.77e-04	GO:0030814	regulation of cAMP metabolic process
2.31	5.60e-04	GO:0030802	regulation of cyclic nucleotide biosynthetic process
2.31	5.60e-04	GO:0030808	regulation of nucleotide biosynthetic process
2.25	1.18e-03	GO:0030799	regulation of cyclic nucleotide metabolic process
1.97	1.71e-03	GO:0045664	regulation of neuron differentiation
1.95	6.55e-03	GO:0051051	negative regulation of transport
1.90	8.46e-04	GO:0050767	regulation of neurogenesis
1.89	2.86e-05	GO:0060284	regulation of cell development
1.88	1.50e-05	GO:0044057	regulation of system process
1.82	1.61e-03	GO:0051960	regulation of nervous system development
1.76	2.32e-03	GO:0006140	regulation of nucleotide metabolic process
1.67	1.37e-02	GO:0051240	positive regulation of multicellular organismal process
1.66	7.38e-03	GO:0090066	regulation of anatomical structure size
1.57	8.89e-05	GO:0045595	regulation of cell differentiation
1.53	1.04e-09	GO:0051239	regulation of multicellular organismal process

Gene overrepresentation in compartment category:

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Showing 1 to 7 of 7 entries

enrichment	p-value	GO term	description
1.44	1.18e-02	GO:0030054	cell junction
1.36	2.64e-04	GO:0005887	integral to plasma membrane
1.34	5.13e-04	GO:0031226	intrinsic to plasma membrane
1.30	5.81e-06	GO:0044459	plasma membrane part
1.18	5.42e-05	GO:0071944	cell periphery
1.18	6.06e-05	GO:0005886	plasma membrane
1.10	1.83e-03	GO:0016020	membrane

Gene overrepresentation in function category:

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enrichment	p-value	GO term	description
1.47	4.28e-02	GO:0060589	nucleoside-triphosphatase regulator activity

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Motif ID: SMAD1..7,9.p2

Z-value: 4.325

Transcription factors associated with SMAD1..7,9.p2:

Activity-expression correlation:

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in process category:

Gene overrepresentation in compartment category:

Gene overrepresentation in function category: