Motif ID: SOX17.p2

Z-value: 1.351


Transcription factors associated with SOX17.p2:

Gene SymbolEntrez IDGene Name
SOX17 64321 SRY (sex determining region Y)-box 17

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SOX17chr8_+_55533047-0.058.5e-01Click!


Activity profile for motif SOX17.p2.

activity profile for motif SOX17.p2


Sorted Z-values histogram for motif SOX17.p2

Sorted Z-values for motif SOX17.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX17.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_207668787 2.057 NM_001104548
LOC642587
NPC-A-5
chr5_+_177564140 1.910 HNRNPAB
heterogeneous nuclear ribonucleoprotein A/B
chr5_+_177564139 1.672 HNRNPAB
heterogeneous nuclear ribonucleoprotein A/B
chr5_+_177564102 1.569 NM_004499
NM_031266
HNRNPAB

heterogeneous nuclear ribonucleoprotein A/B

chr2_+_232281491 1.464 PTMA
prothymosin, alpha
chr1_-_204179169 1.319 NM_052934
NM_134325
SLC26A9

solute carrier family 26, member 9

chr2_+_232281470 1.275 NM_001099285
NM_002823
PTMA

prothymosin, alpha

chr3_-_48576204 1.236 NM_033199
UCN2
urocortin 2
chrX_+_77889861 1.170 NM_005296
LPAR4
lysophosphatidic acid receptor 4
chr21_+_33320080 1.134 NM_005806
OLIG2
oligodendrocyte lineage transcription factor 2
chrX_-_24600661 1.131 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr19_+_40958206 1.080 NM_001172630
NM_052948
ARHGAP33

Rho GTPase activating protein 33

chr1_+_226404037 1.021 NM_020435
GJC2
gap junction protein, gamma 2, 47kDa
chr16_-_65774904 1.019 KIAA0895L
KIAA0895-like
chr11_-_16380967 1.012 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr15_+_29406335 1.007 NM_015995
KLF13
Kruppel-like factor 13
chr11_-_66877519 1.006 NM_021173
POLD4
polymerase (DNA-directed), delta 4
chr4_-_2233504 0.976 NM_006454
MXD4
MAX dimerization protein 4
chr19_+_748444 0.951 PTBP1
polypyrimidine tract binding protein 1
chr19_+_748448 0.943 PTBP1
polypyrimidine tract binding protein 1
chr9_+_136358145 0.929 RXRA
retinoid X receptor, alpha
chr5_+_148186348 0.914 NM_000024
ADRB2
adrenergic, beta-2-, receptor, surface
chr9_-_132759045 0.910 NM_198180
QRFP
pyroglutamylated RFamide peptide
chrX_-_10605726 0.894 NM_001098624
MID1
midline 1 (Opitz/BBB syndrome)
chrX_+_41078787 0.891 DDX3X
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked
chr9_+_136358134 0.889 NM_002957
RXRA
retinoid X receptor, alpha
chr4_-_2233606 0.886 MXD4
MAX dimerization protein 4
chr15_-_70277163 0.863 NM_001012642
GRAMD2
GRAM domain containing 2
chr11_+_35154775 0.851 CD44
CD44 molecule (Indian blood group)
chr13_-_107317460 0.830 NM_001080396
FAM155A
family with sequence similarity 155, member A
chr14_-_105623358 0.807 IGHA1
IGHD
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
chr12_-_6535481 0.794 NM_001039670
NM_001193457
NM_080730
IFFO1


intermediate filament family orphan 1


chr5_+_176807931 0.785 NM_001174102
PRR7
proline rich 7 (synaptic)
chr10_-_32707549 0.773 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr9_+_139255559 0.762 TUBB2C
tubulin, beta 2C
chr10_+_46413551 0.750 NM_014696
GPRIN2
G protein regulated inducer of neurite outgrowth 2
chr11_+_113280727 0.748 NM_006028
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B
chr9_+_139255519 0.745 NM_006088
TUBB2C
tubulin, beta 2C
chr11_-_20138445 0.721 NM_001029865
DBX1
developing brain homeobox 1
chr17_-_8054587 0.721 NM_004217
AURKB
aurora kinase B
chr6_+_50789215 0.714 NM_172238
TFAP2D
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chr6_+_33047952 0.712 BRD2
bromodomain containing 2
chr9_+_139255563 0.710 TUBB2C
tubulin, beta 2C
chr1_+_1104939 0.707 NM_153254
TTLL10
tubulin tyrosine ligase-like family, member 10
chr16_+_580173 0.704 NM_021168
RAB40C
RAB40C, member RAS oncogene family
chr3_-_46879883 0.699 NM_000258
MYL3
myosin, light chain 3, alkali; ventricular, skeletal, slow
chr17_-_71648965 0.698 NM_001454
FOXJ1
forkhead box J1
chr7_+_116447499 0.690 ST7
suppression of tumorigenicity 7
chr11_+_60448487 0.672 NM_017870
NM_178031
TMEM132A

transmembrane protein 132A

chr3_+_128190070 0.664 NM_032242
PLXNA1
plexin A1
chr16_+_580057 0.662 NM_001172665
NM_001172666
RAB40C

RAB40C, member RAS oncogene family

chr19_+_748452 0.662 PTBP1
polypyrimidine tract binding protein 1
chr19_+_13090101 0.659 NM_052876
NACC1
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
chrX_+_41078353 0.655 DDX3X
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked
chr17_-_1478293 0.651 SLC43A2
solute carrier family 43, member 2
chr4_+_154345039 0.650 NM_015271
TRIM2
tripartite motif containing 2
chr21_-_35153664 0.648 RUNX1
runt-related transcription factor 1
chr1_+_23990228 0.648 NM_007260
LYPLA2
lysophospholipase II
chr4_+_75529716 0.645 NM_001657
AREG
amphiregulin
chr1_+_201541269 0.643 NM_006763
BTG2
BTG family, member 2
chr19_+_1401117 0.640 NM_005883
APC2
adenomatosis polyposis coli 2
chr16_+_580092 0.633 RAB40C
RAB40C, member RAS oncogene family
chr1_+_1971762 0.607 NM_002744
PRKCZ
protein kinase C, zeta
chr22_-_17892859 0.606 NM_001130861
NM_003277
CLDN5

claudin 5

chr19_+_748390 0.606 NM_002819
NM_031990
NM_031991
NM_175847
PTBP1



polypyrimidine tract binding protein 1



chr21_+_33364316 0.601 NM_138983
OLIG1
oligodendrocyte transcription factor 1
chr20_-_61933012 0.598 ZBTB46
zinc finger and BTB domain containing 46
chr7_+_148613304 0.594 LOC155060
AI894139 pseudogene
chr1_+_1256585 0.583 NM_152228
TAS1R3
taste receptor, type 1, member 3
chr17_-_45617899 0.576 COL1A1
collagen, type I, alpha 1
chr15_-_53822468 0.573 NM_173814
PRTG
protogenin
chr19_+_60543032 0.570 NM_032701
SUV420H2
suppressor of variegation 4-20 homolog 2 (Drosophila)
chr19_+_11510578 0.570 NM_001299
CNN1
calponin 1, basic, smooth muscle
chr17_-_71747867 0.568 NM_052916
RNF157
ring finger protein 157
chr19_+_59333232 0.563 NM_014516
CNOT3
CCR4-NOT transcription complex, subunit 3
chr12_-_98072602 0.561 NM_020140
NM_181670
ANKS1B

ankyrin repeat and sterile alpha motif domain containing 1B

chr7_+_116447527 0.561 ST7
suppression of tumorigenicity 7
chr1_+_201541241 0.560 BTG2
BTG family, member 2
chr8_+_1759502 0.560 NM_014629
ARHGEF10
Rho guanine nucleotide exchange factor (GEF) 10
chr1_+_154855709 0.553 NM_021817
HAPLN2
hyaluronan and proteoglycan link protein 2
chr22_+_20316968 0.553 NM_152612
CCDC116
coiled-coil domain containing 116
chr1_+_110683580 0.546 RBM15
RNA binding motif protein 15
chr7_-_27171673 0.539 NM_152739
HOXA9
homeobox A9
chr6_+_25862905 0.534 NM_005495
SLC17A4
solute carrier family 17 (sodium phosphate), member 4
chr17_+_7125702 0.531 NM_001042
SLC2A4
solute carrier family 2 (facilitated glucose transporter), member 4
chr3_-_187309442 0.530 NM_004454
ETV5
ets variant 5
chr1_+_203463654 0.528 NM_014858
TMCC2
transmembrane and coiled-coil domain family 2
chr19_+_1401208 0.527 APC2
adenomatosis polyposis coli 2
chr19_+_59333287 0.523 CNOT3
CCR4-NOT transcription complex, subunit 3
chr1_-_50661716 0.520 NM_032110
DMRTA2
DMRT-like family A2
chr11_+_823007 0.520 CD151
CD151 molecule (Raph blood group)
chr12_+_6517600 0.519


chr1_+_32485404 0.515 NM_032648
FAM167B
family with sequence similarity 167, member B
chr17_+_72376022 0.515 NM_144677
MGAT5B
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B
chr6_+_43319199 0.514 NM_032538
TTBK1
tau tubulin kinase 1
chr4_+_75699652 0.509 NM_001657
AREG
amphiregulin
chr10_-_134449467 0.506 NM_177400
NKX6-2
NK6 homeobox 2
chr3_-_12916547 0.504 IQSEC1
IQ motif and Sec7 domain 1
chr1_+_148089251 0.503 NM_001040874
NM_003516
HIST2H2AA4
HIST2H2AA3
histone cluster 2, H2aa4
histone cluster 2, H2aa3
chr19_+_750281 0.502 PTBP1
polypyrimidine tract binding protein 1
chr17_-_77092569 0.500 ACTG1
actin, gamma 1
chr16_-_65775326 0.498 NM_001040715
KIAA0895L
KIAA0895-like
chr1_+_110683586 0.496 RBM15
RNA binding motif protein 15
chrX_+_67965517 0.496 NM_004429
EFNB1
ephrin-B1
chr13_-_29938029 0.495 NM_002128
HMGB1
high-mobility group box 1
chr12_+_47658502 0.492 NM_005430
WNT1
wingless-type MMTV integration site family, member 1
chr1_+_116455898 0.491 NM_152367
MAB21L3
mab-21-like 3 (C. elegans)
chr21_-_36870736 0.489 NM_001146077
CLDN14
claudin 14
chr21_+_33364420 0.488 OLIG1
oligodendrocyte transcription factor 1
chr12_-_94914133 0.487 NM_002108
HAL
histidine ammonia-lyase
chr3_-_51976428 0.486 NM_020418
NM_001174100
NM_033008
PCBP4


poly(rC) binding protein 4


chr16_-_11282595 0.485 NM_002761
PRM1
protamine 1
chr19_-_10352172 0.483 TYK2
tyrosine kinase 2
chr10_-_13430195 0.482 NM_001195602
NM_001195604
NM_012247
SEPHS1


selenophosphate synthetase 1


chr11_+_822965 0.479 CD151
CD151 molecule (Raph blood group)
chr16_-_30274182 0.478 NM_006110
CD2BP2
CD2 (cytoplasmic tail) binding protein 2
chr1_-_51560469 0.477 NM_001080494
TTC39A
tetratricopeptide repeat domain 39A
chr17_+_72883759 0.475 NM_001113494
SEPT9
septin 9
chr17_-_7996409 0.472 NM_002616
PER1
period homolog 1 (Drosophila)
chr16_-_2201011 0.471 NM_182563
C16orf79
chromosome 16 open reading frame 79
chr19_+_53819460 0.468 SPHK2
sphingosine kinase 2
chr15_+_76171981 0.465 NM_001101404
SH2D7
SH2 domain containing 7
chrX_+_99726445 0.465 NM_022144
TNMD
tenomodulin
chr17_+_45598363 0.460 NM_000023
NM_001135697
SGCA

sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)

chr11_-_71501385 0.459 NM_014042
C11orf51
chromosome 11 open reading frame 51
chr11_+_18676857 0.458 TMEM86A
transmembrane protein 86A
chr10_+_73703682 0.457 NM_019058
DDIT4
DNA-damage-inducible transcript 4
chr17_+_45617676 0.457


chr1_+_43597185 0.454 NM_001255
CDC20
cell division cycle 20 homolog (S. cerevisiae)
chr5_+_54434230 0.453 NM_006144
GZMA
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
chr1_+_110683467 0.452 NM_022768
RBM15
RNA binding motif protein 15
chr15_+_72687765 0.452 NM_003992
CLK3
CDC-like kinase 3
chr1_+_175406685 0.451 FAM5B
family with sequence similarity 5, member B
chr11_-_780065 0.449 CEND1
cell cycle exit and neuronal differentiation 1
chr11_+_17697685 0.448 NM_002478
MYOD1
myogenic differentiation 1
chr5_+_148717762 0.448 NM_024028
PCYOX1L
prenylcysteine oxidase 1 like
chr15_-_38188333 0.446 NM_001003940
BMF
Bcl2 modifying factor
chr17_-_39632845 0.445 ATXN7L3
ataxin 7-like 3
chr1_+_11674365 0.445 NM_198545
C1orf187
chromosome 1 open reading frame 187
chr16_+_67697622 0.444 NM_138612
HAS3
hyaluronan synthase 3
chr5_+_170668892 0.443 NM_021025
TLX3
T-cell leukemia homeobox 3
chr6_-_31890765 0.443 NM_005527
HSPA1L
heat shock 70kDa protein 1-like
chr11_+_822909 0.443 NM_001039490
NM_004357
NM_139029
NM_139030
CD151



CD151 molecule (Raph blood group)



chr22_+_17498320 0.442 NM_053006
TSSK2
testis-specific serine kinase 2
chr2_-_128138435 0.441 NM_017980
LIMS2
LIM and senescent cell antigen-like domains 2
chr12_+_105501161 0.441 NM_213594
RFX4
regulatory factor X, 4 (influences HLA class II expression)
chrX_+_41077594 0.440 NM_001193416
NM_001193417
NM_001356
DDX3X


DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked


chr7_-_27171648 0.440 HOXA9
homeobox A9
chr1_-_155095289 0.437 NM_014215
INSRR
insulin receptor-related receptor
chr6_+_30796064 0.436 TUBB
tubulin, beta
chr15_+_37660568 0.436 NM_003246
THBS1
thrombospondin 1
chr17_+_77574476 0.431 NM_144999
LRRC45
leucine rich repeat containing 45
chr1_-_23543330 0.430 NM_001102397
NM_001102398
NM_001102399
NM_005826
HNRNPR



heterogeneous nuclear ribonucleoprotein R



chr16_-_30274064 0.428 CD2BP2
CD2 (cytoplasmic tail) binding protein 2
chr16_-_28425632 0.428 NM_145659
IL27
interleukin 27
chr1_+_148125090 0.426 NM_003517
HIST2H2AC
histone cluster 2, H2ac
chr5_-_131854325 0.425 NM_002198
IRF1
interferon regulatory factor 1
chr13_-_98428244 0.424 NM_001130048
NM_001130050
DOCK9

dedicator of cytokinesis 9

chr11_-_65813031 0.423 YIF1A
Yip1 interacting factor homolog A (S. cerevisiae)
chr11_+_18676913 0.423 NM_153347
TMEM86A
transmembrane protein 86A
chr17_-_59131210 0.422 NM_030576
LIMD2
LIM domain containing 2
chr1_+_148090804 0.420 NM_021059
NM_001005464
HIST2H3C
HIST2H3A
histone cluster 2, H3c
histone cluster 2, H3a
chrX_+_106030049 0.418 NM_001171092
CLDN2
claudin 2
chr22_+_38246509 0.414 NM_001675
NM_182810
ATF4

activating transcription factor 4 (tax-responsive enhancer element B67)

chr17_+_77528782 0.413 ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr1_-_41259973 0.412 NM_001168247
NM_144990
SLFNL1

schlafen-like 1

chr9_-_138778780 0.409 NM_203347
LCN15
lipocalin 15
chr19_-_6230927 0.408 NM_005934
MLLT1
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
chr1_+_154386358 0.407 NM_001193301
SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr7_+_123036312 0.404 NM_080928
ASB15
ankyrin repeat and SOCS box containing 15
chr15_-_100280784 0.404 NM_001004195
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr13_-_29937966 0.402 HMGB1
HMGB1P6
high-mobility group box 1
high-mobility group box 1 pseudogene 6
chr17_-_77573974 0.402 NM_144998
STRA13
stimulated by retinoic acid 13 homolog (mouse)
chr22_+_36632242 0.399 NM_033386
MICALL1
MICAL-like 1
chr10_+_114033403 0.397 NM_058222
TECTB
tectorin beta
chr1_+_196153122 0.396 NM_020204
LHX9
LIM homeobox 9
chr7_+_134114957 0.394 CALD1
caldesmon 1
chr9_+_134843918 0.393 NM_001135031
NM_004188
GFI1B

growth factor independent 1B transcription repressor

chr12_+_105500814 0.391 RFX4
regulatory factor X, 4 (influences HLA class II expression)
chr19_+_2115119 0.390 NM_032482
DOT1L
DOT1-like, histone H3 methyltransferase (S. cerevisiae)
chr19_+_47593137 0.390


chr4_-_41445479 0.386 PHOX2B
paired-like homeobox 2b
chr9_+_91409746 0.385 NM_006705
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr20_-_538909 0.385 NM_004609
TCF15
transcription factor 15 (basic helix-loop-helix)
chr3_-_58175437 0.384 NM_004944
DNASE1L3
deoxyribonuclease I-like 3
chr6_-_110843432 0.383 NM_003649
NM_004032
DDO

D-aspartate oxidase

chr19_-_3930828 0.383 EEF2
eukaryotic translation elongation factor 2
chr11_-_63440891 0.382 NM_173587
RCOR2
REST corepressor 2
chr9_-_139084833 0.381 NM_178448
C9orf140
chromosome 9 open reading frame 140
chr17_+_7416780 0.381 NM_001416
EIF4A1
eukaryotic translation initiation factor 4A1
chr12_-_49076658 0.381 NM_001145475
FAM186A
family with sequence similarity 186, member A
chr11_-_59139755 0.380 OSBP
oxysterol binding protein
chr17_+_77529070 0.376 ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr12_-_67012303 0.376 NM_017440
NM_020128
MDM1

Mdm1 nuclear protein homolog (mouse)

chr22_-_17512097 0.376 DGCR14
DiGeorge syndrome critical region gene 14
chr2_-_73151894 0.373 SFXN5
sideroflexin 5
chr1_-_226679648 0.371 NM_003493
HIST3H3
histone cluster 3, H3
chr22_-_17512174 0.370 NM_022719
DGCR14
DiGeorge syndrome critical region gene 14
chr11_+_20577521 0.368 NM_004211
SLC6A5
solute carrier family 6 (neurotransmitter transporter, glycine), member 5
chr1_-_16033866 0.368



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.24 8.04e-05 GO:0007275 multicellular organismal development
1.23 9.37e-05 GO:0032502 developmental process
1.18 1.31e-04 GO:0032501 multicellular organismal process
1.38 4.07e-04 GO:0007399 nervous system development
1.24 7.04e-04 GO:0048856 anatomical structure development
1.25 1.42e-03 GO:0048731 system development
1.84 4.02e-03 GO:0030029 actin filament-based process
1.60 9.42e-03 GO:0007417 central nervous system development
1.27 3.95e-02 GO:0048513 organ development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.72 5.09e-03 GO:0000786 nucleosome
1.13 8.58e-03 GO:0005634 nucleus

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.53 9.92e-07 GO:0030528 transcription regulator activity
1.41 2.04e-03 GO:0001071 nucleic acid binding transcription factor activity
1.41 2.04e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
1.25 2.44e-03 GO:0003677 DNA binding
1.68 1.21e-02 GO:0003779 actin binding
1.17 4.06e-02 GO:0003676 nucleic acid binding