Motif ID: SP1.p2

Z-value: 2.777


Transcription factors associated with SP1.p2:

Gene SymbolEntrez IDGene Name
SP1 6667 Sp1 transcription factor

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SP1chr12_+_520601910.467.2e-02Click!


Activity profile for motif SP1.p2.

activity profile for motif SP1.p2


Sorted Z-values histogram for motif SP1.p2

Sorted Z-values for motif SP1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SP1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr22_+_20101661 5.750 NM_015094
 HIC2
hypermethylated in cancer 2
chr6_+_37245860 4.766 NM_002648
 PIM1
pim-1 oncogene
chr17_+_78630793 3.995 NM_001004431
 METRNL
meteorin, glial cell differentiation regulator-like
chr6_+_43846735 3.584 VEGFA
vascular endothelial growth factor A
chr17_+_77582774 3.580 NM_005052
 RAC3
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
chr9_+_132961723 3.566 AIF1L
allograft inflammatory factor 1-like
chr20_+_30410447 3.260 ASXL1
additional sex combs like 1 (Drosophila)
chr20_+_32045386 3.253 NM_007367
NM_016732
 RALY

RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse))

chr7_+_73506333 3.195 NM_005685
 GTF2IRD1
GTF2I repeat domain containing 1
chr20_+_254205 3.180 NM_006943
 SOX12
SRY (sex determining region Y)-box 12
chr22_-_19122107 3.064 NM_153334
NM_182895
 SCARF2

scavenger receptor class F, member 2

chr20_+_32045214 3.049 RALY
RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse))
chr2_+_10101081 2.978 NM_003597
NM_001177716
 KLF11

Kruppel-like factor 11

chr20_+_32045087 2.977 RALY
RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse))
chr1_+_945331 2.915 NM_198576
 AGRN
agrin
chr1_+_167342149 2.894 ATP1B1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr19_+_59064795 2.879 MYADM
myeloid-associated differentiation marker
chr7_+_73506172 2.872 GTF2IRD1
GTF2I repeat domain containing 1
chr5_+_139008667 2.867 CXXC5
CXXC finger protein 5
chr22_+_21742364 2.840 NM_002073
 GNAZ
guanine nucleotide binding protein (G protein), alpha z polypeptide

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 93 entries
enrichment   p-value GO term description
1.29 9.48e-03 GO:0016568 chromatin modification
1.29 3.09e-02 GO:0007411 axon guidance
1.27 5.30e-08 GO:0006351 transcription, DNA-dependent
1.26 4.62e-02 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.25 4.45e-04 GO:0010629 negative regulation of gene expression
1.25 9.16e-03 GO:0072358 cardiovascular system development
1.25 9.16e-03 GO:0072359 circulatory system development
1.25 2.94e-02 GO:0048812 neuron projection morphogenesis
1.25 3.70e-02 GO:0007409 axonogenesis
1.24 5.69e-07 GO:0032774 RNA biosynthetic process
1.24 9.09e-03 GO:0045892 negative regulation of transcription, DNA-dependent
1.23 2.16e-02 GO:0051253 negative regulation of RNA metabolic process
1.23 4.46e-02 GO:0031175 neuron projection development
1.22 7.53e-05 GO:0010605 negative regulation of macromolecule metabolic process
1.22 6.05e-03 GO:0010558 negative regulation of macromolecule biosynthetic process
1.22 1.48e-02 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.20 2.40e-04 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.20 4.99e-04 GO:0009892 negative regulation of metabolic process
1.20 6.38e-03 GO:0022402 cell cycle process
1.20 2.60e-02 GO:0009890 negative regulation of biosynthetic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 30 entries
enrichment   p-value GO term description
1.47 4.38e-02 GO:0016585 chromatin remodeling complex
1.29 5.11e-03 GO:0005874 microtubule
1.26 1.65e-02 GO:0005815 microtubule organizing center
1.24 2.42e-05 GO:0015630 microtubule cytoskeleton
1.21 2.78e-09 GO:0005654 nucleoplasm
1.20 2.92e-12 GO:0031981 nuclear lumen
1.20 1.65e-03 GO:0044451 nucleoplasm part
1.19 8.59e-13 GO:0044428 nuclear part
1.18 3.00e-11 GO:0070013 intracellular organelle lumen
1.17 5.91e-11 GO:0031974 membrane-enclosed lumen
1.17 9.07e-11 GO:0043233 organelle lumen
1.17 2.10e-09 GO:0005829 cytosol
1.16 8.02e-06 GO:0012505 endomembrane system
1.15 9.70e-03 GO:0005783 endoplasmic reticulum
1.14 3.54e-23 GO:0005634 nucleus
1.13 6.34e-08 GO:0043234 protein complex
1.13 8.21e-05 GO:0031090 organelle membrane
1.11 1.16e-34 GO:0043227 membrane-bounded organelle
1.11 1.70e-34 GO:0043231 intracellular membrane-bounded organelle
1.11 2.21e-15 GO:0044444 cytoplasmic part

Gene overrepresentation in function category:

Showing 1 to 20 of 26 entries
enrichment   p-value GO term description
1.63 2.11e-03 GO:0042393 histone binding
1.46 1.81e-02 GO:0015631 tubulin binding
1.36 1.78e-02 GO:0003682 chromatin binding
1.33 3.66e-04 GO:0016564 transcription repressor activity
1.24 1.64e-03 GO:0008092 cytoskeletal protein binding
1.22 6.78e-07 GO:0001071 nucleic acid binding transcription factor activity
1.22 6.78e-07 GO:0003700 sequence-specific DNA binding transcription factor activity
1.20 2.39e-05 GO:0030528 transcription regulator activity
1.16 6.78e-10 GO:0003677 DNA binding
1.16 8.95e-08 GO:0008270 zinc ion binding
1.15 2.72e-08 GO:0046914 transition metal ion binding
1.14 1.38e-11 GO:0003676 nucleic acid binding
1.14 3.25e-06 GO:0000166 nucleotide binding
1.14 3.69e-05 GO:0032553 ribonucleotide binding
1.14 3.69e-05 GO:0032555 purine ribonucleotide binding
1.14 4.55e-05 GO:0017076 purine nucleotide binding
1.13 2.73e-04 GO:0035639 purine ribonucleoside triphosphate binding
1.13 3.98e-03 GO:0032559 adenyl ribonucleotide binding
1.13 4.88e-03 GO:0030554 adenyl nucleotide binding
1.12 9.67e-27 GO:0005515 protein binding