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• Activity deltas table
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Motif ID: SPIB.p2

Z-value: 1.380

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr18_+_30875297	2.809	NM_014268	MAPRE2	microtubule-associated protein, RP/EB family, member 2
chr3_+_180348818	1.952	NM_006218	PIK3CA	phosphoinositide-3-kinase, catalytic, alpha polypeptide
chr6_+_130381408	1.486	NM_001007102 NM_032438	L3MBTL3	l(3)mbt-like 3 (Drosophila)
chr5_+_139485703	1.316	NM_001007189	C5orf53	chromosome 5 open reading frame 53
chr13_-_32678142	1.114	NM_052851	STARD13	StAR-related lipid transfer (START) domain containing 13
chr11_+_86426518	1.095	NM_001168724 NM_022918	TMEM135	transmembrane protein 135
chr2_+_36436873	0.950	NM_016441	CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr4_+_152417774	0.945	NM_183375	PRSS48	protease, serine, 48
chr6_+_12398514	0.935	NM_001168319 NM_001955	EDN1	endothelin 1
chr8_+_64243741	0.907		YTHDF3	YTH domain family, member 3
chr8_+_64243662	0.904	NM_152758	YTHDF3	YTH domain family, member 3
chr6_+_144040751	0.876	NM_001100164 NM_001100165	PHACTR2	phosphatase and actin regulator 2
chr6_+_7052798	0.848	NM_001168344	RREB1	ras responsive element binding protein 1
chr14_+_99601498	0.844	NM_016337	EVL	Enah/Vasp-like
chr20_-_48980858	0.841	NM_015339 NM_181442	ADNP	activity-dependent neuroprotector homeobox
chr1_-_205272619	0.780	NM_001083924 NM_023938	C1orf116	chromosome 1 open reading frame 116
chr1_+_158636987	0.767	NM_020335	VANGL2	vang-like 2 (van gogh, Drosophila)
chr7_-_104440707	0.765		LOC100216545	hypothetical LOC100216545
chr6_+_7053183	0.732		RREB1	ras responsive element binding protein 1
chr20_-_2031521	0.727
chr8_+_28803804	0.724	NM_001135726	HMBOX1	homeobox containing 1
chr2_-_175207521	0.715	NM_003387	WIPF1	WAS/WASL interacting protein family, member 1
chr2_-_21084911	0.712		APOB	apolipoprotein B (including Ag(x) antigen)
chr14_+_99601517	0.711		EVL	Enah/Vasp-like
chr12_-_26166485	0.703		BHLHE41	basic helix-loop-helix family, member e41
chr16_+_24696069	0.690		TNRC6A	trinucleotide repeat containing 6A
chr11_-_9182356	0.690		DENND5A	DENN/MADD domain containing 5A
chr3_+_153499883	0.690	NM_207293 NM_207294 NM_207295 NM_207296 NM_207297	MBNL1	muscleblind-like (Drosophila)
chr8_-_28803341	0.689	NM_001172562	INTS9	integrator complex subunit 9
chr8_-_28803616	0.670	NM_001145159 NM_018250	INTS9	integrator complex subunit 9
chr17_+_24742068	0.670	NM_020791	TAOK1	TAO kinase 1
chr3_+_120495906	0.665	NM_020754	ARHGAP31	Rho GTPase activating protein 31
chr4_+_87070449	0.628	NM_031305	ARHGAP24	Rho GTPase activating protein 24
chr1_+_27972269	0.627	NM_177424	STX12	syntaxin 12
chr20_+_2031418	0.614		STK35	serine/threonine kinase 35
chr5_+_10406829	0.611		MARCH6	membrane-associated ring finger (C3HC4) 6
chr6_+_7052985	0.608	NM_001003698 NM_001003699 NM_001003700	RREB1	ras responsive element binding protein 1
chr2_+_149118791	0.606		EPC2	enhancer of polycomb homolog 2 (Drosophila)
chr2_+_155263338	0.606	NM_002239	KCNJ3	potassium inwardly-rectifying channel, subfamily J, member 3
chr14_+_38720085	0.605		PNN	pinin, desmosome associated protein
chr17_+_44643067	0.604		ABI3	ABI family, member 3
chr16_+_31105579	0.599
chr9_+_119506446	0.597		TLR4	toll-like receptor 4
chr9_+_119506274	0.592	NM_138554	TLR4	toll-like receptor 4
chr12_-_70953461	0.590		LOC283392	hypothetical LOC283392
chr3_+_138020550	0.579	NM_001097599 NM_001097600 NM_025246	TMEM22	transmembrane protein 22
chr12_-_11215396	0.579	NM_001098538 NM_006250	PRH1-PRR4 PRR4 TAS2R14 PRH1	PRH1-PRR4 read-through transcript proline rich 4 (lacrimal) taste receptor, type 2, member 14 proline-rich protein HaeIII subfamily 1
chr14_-_20969706	0.572	NM_001170629	CHD8	chromodomain helicase DNA binding protein 8
chr2_+_46779553	0.561	NM_014011	SOCS5	suppressor of cytokine signaling 5
chr3_+_98966253	0.555	NM_032146 NM_177976	ARL6	ADP-ribosylation factor-like 6
chr15_+_94676691	0.551	NM_001145156	NR2F2	nuclear receptor subfamily 2, group F, member 2
chr17_-_36376663	0.550	NM_213656	KRT39	keratin 39
chr13_+_44937025	0.549	NM_031431	COG3	component of oligomeric golgi complex 3
chr9_+_114289178	0.546		KIAA1958	KIAA1958
chr9_+_119506428	0.542		TLR4	toll-like receptor 4
chr6_-_56816403	0.540		DST	dystonin
chr15_+_55298908	0.522	NM_207040	TCF12	transcription factor 12
chr1_-_181826633	0.521	NM_001127651	NCF2	neutrophil cytosolic factor 2
chr5_+_52131686	0.515		PELO	pelota homolog (Drosophila)
chr3_+_101811122	0.509	NM_032787	GPR128	G protein-coupled receptor 128
chr5_-_32439067	0.505		ZFR	zinc finger RNA binding protein
chr3_+_195889845	0.502		FAM43A	family with sequence similarity 43, member A
chr12_+_95112385	0.501		ELK3	ELK3, ETS-domain protein (SRF accessory protein 2)
chr6_+_21701942	0.497	NM_003107	SOX4	SRY (sex determining region Y)-box 4
chr10_+_31647425	0.496		ZEB1	zinc finger E-box binding homeobox 1
chr6_+_153060722	0.496	NM_025107	MYCT1	myc target 1
chr2_-_160838397	0.491		RBMS1	RNA binding motif, single stranded interacting protein 1
chr17_+_63252704	0.491		BPTF	bromodomain PHD finger transcription factor
chr22_+_39818553	0.490	NM_001429	EP300	E1A binding protein p300
chr5_+_132237253	0.489	NM_052971	LEAP2	liver expressed antimicrobial peptide 2
chr18_-_16945763	0.486	NM_005406	ROCK1	Rho-associated, coiled-coil containing protein kinase 1
chr12_-_23995109	0.485		SOX5	SRY (sex determining region Y)-box 5
chr11_+_8660913	0.483		RPL27A	ribosomal protein L27a
chr14_-_21074875	0.479	NM_005407	SALL2	sal-like 2 (Drosophila)
chr4_+_91035025	0.477	NM_007351	MMRN1	multimerin 1
chr2_+_118562499	0.476	NM_016133	INSIG2	insulin induced gene 2
chr20_+_42947754	0.476	NM_003404 NM_139323	YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
chr14_+_54104099	0.472		SAMD4A	sterile alpha motif domain containing 4A
chr7_+_86619580	0.472	NM_001142326 NM_001142327	DMTF1	cyclin D binding myb-like transcription factor 1
chr20_+_42947764	0.471		YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
chr1_+_93317374	0.471	NM_001164391 NM_001164392 NM_001164393 NM_007358	MTF2	metal response element binding transcription factor 2
chr15_+_72620570	0.471	NM_006465	ARID3B	AT rich interactive domain 3B (BRIGHT-like)
chr4_-_174557191	0.469	NM_007281	SCRG1	stimulator of chondrogenesis 1
chr2_-_55090759	0.466	NM_007008	RTN4	reticulon 4
chr1_+_13948448	0.464	NM_001007257	PRDM2	PR domain containing 2, with ZNF domain
chr13_+_98951772	0.463		TM9SF2	transmembrane 9 superfamily member 2
chr5_+_52119442	0.459	NM_181501 NM_015946	ITGA1 PELO	integrin, alpha 1 pelota homolog (Drosophila)
chr11_+_64950074	0.453		NEAT1	nuclear paraspeckle assembly transcript 1 (non-protein coding)
chr5_+_36912656	0.452		NIPBL	Nipped-B homolog (Drosophila)
chr10_+_17312654	0.450		VIM	vimentin
chr4_+_109761170	0.449	NM_000995 NM_033625	RPL34	ribosomal protein L34
chr9_+_102244005	0.445	NM_001198812	C9orf3-TMEFF1 C9orf30	C9orf3-TMEFF1 readthrough chromosome 9 open reading frame 30
chr1_+_183970093	0.440	NM_031935	HMCN1	hemicentin 1
chr16_-_70306198	0.438	NM_015020	PHLPP2	PH domain and leucine rich repeat protein phosphatase 2
chr14_-_24047261	0.437	NM_001836	CMA1	chymase 1, mast cell
chr14_+_23937766	0.435	NM_025081	NYNRIN	NYN domain and retroviral integrase containing
chr5_+_79739548	0.435	NM_001105251 NM_014733	ZFYVE16	zinc finger, FYVE domain containing 16
chr8_-_82522175	0.434	NM_002677	PMP2	peripheral myelin protein 2
chr2_+_36436316	0.433		CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr6_-_32268267	0.432		GPSM3	G-protein signaling modulator 3
chr3_+_120496180	0.431		ARHGAP31	Rho GTPase activating protein 31
chr10_+_18988282	0.430	NM_178815	ARL5B	ADP-ribosylation factor-like 5B
chr10_-_18988172	0.430
chr3_-_107070400	0.426	NM_170662	CBLB	Cas-Br-M (murine) ecotropic retroviral transforming sequence b
chr5_-_58370693	0.422	NM_001197221 NM_001197222	PDE4D	phosphodiesterase 4D, cAMP-specific
chr10_-_27189898	0.421		ABI1	abl-interactor 1
chr6_+_7053863	0.420		RREB1	ras responsive element binding protein 1
chr14_+_49157150	0.419	NM_002408	MGAT2	mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr2_+_149119029	0.419	NM_015630	EPC2	enhancer of polycomb homolog 2 (Drosophila)
chr8_+_90983934	0.411	NM_001126111	OSGIN2	oxidative stress induced growth inhibitor family member 2
chr20_+_13924263	0.406		MACROD2	MACRO domain containing 2
chr2_+_64604940	0.406	NM_001002243 NM_017657 NM_203437	AFTPH	aftiphilin
chr2_+_54638957	0.404	NM_178313	SPTBN1	spectrin, beta, non-erythrocytic 1
chr3_+_114948550	0.403	NM_001690	ATP6V1A	ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr20_+_30409649	0.402	NM_001164603 NM_015338	ASXL1	additional sex combs like 1 (Drosophila)
chr8_-_38245694	0.402	NM_001102559 NM_001102560 NM_032483	PPAPDC1B	phosphatidic acid phosphatase type 2 domain containing 1B
chr11_-_5419358	0.400	NM_001005288	OR51I1	olfactory receptor, family 51, subfamily I, member 1
chr1_+_36169260	0.399	NM_024852 NM_177422	EIF2C3	eukaryotic translation initiation factor 2C, 3
chr14_+_64041170	0.398		ZBTB1	zinc finger and BTB domain containing 1
chr13_+_98951653	0.396	NM_004800	TM9SF2	transmembrane 9 superfamily member 2
chr21_-_30614477	0.394	NM_203405	KRTAP26-1	keratin associated protein 26-1
chr5_-_54504590	0.393	NM_001145734 NM_001170402 NM_152623	CDC20B	cell division cycle 20 homolog B (S. cerevisiae)
chr17_+_63252668	0.393		BPTF	bromodomain PHD finger transcription factor
chr6_+_47732181	0.392	NM_153839	GPR111	G protein-coupled receptor 111
chr12_-_15005761	0.390	NM_001175	ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta
chr3_-_69674412	0.390		FRMD4B	FERM domain containing 4B
chr22_-_34566210	0.388		RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2
chr2_+_187162969	0.387	NM_001145000 NM_002210	ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
chr12_+_51686512	0.386		EIF4B	eukaryotic translation initiation factor 4B
chr2_-_47986160	0.384	NM_001190274	FBXO11	F-box protein 11
chr1_+_246635918	0.384	NM_030904	OR2T1	olfactory receptor, family 2, subfamily T, member 1
chr22_-_34566367	0.384	NM_001031695 NM_001082576 NM_001082577 NM_014309	RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2
chr3_+_99934227	0.384	NM_006100	ST3GAL6	ST3 beta-galactoside alpha-2,3-sialyltransferase 6
chr20_-_42249631	0.383	NM_020433 NM_175913	JPH2	junctophilin 2
chr2_-_213723298	0.381	NM_016260	IKZF2	IKAROS family zinc finger 2 (Helios)
chr5_+_112340326	0.380	NM_152624	DCP2	DCP2 decapping enzyme homolog (S. cerevisiae)
chr16_-_65781499	0.379	NM_178516	EXOC3L1	exocyst complex component 3-like 1
chr11_+_64950402	0.379
chr9_+_114288899	0.375	NM_133465	KIAA1958	KIAA1958
chr1_+_182040837	0.375		RGL1	ral guanine nucleotide dissociation stimulator-like 1
chr1_+_26896519	0.374		ARID1A	AT rich interactive domain 1A (SWI-like)
chr6_+_57290357	0.371	NM_000947	PRIM2	primase, DNA, polypeptide 2 (58kDa)
chr22_-_34566276	0.370		RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2
chr3_-_114176401	0.370	NM_138806 NM_138939 NM_138940 NM_170780	CD200R1	CD200 receptor 1
chr7_+_37926943	0.369		EPDR1	ependymin related protein 1 (zebrafish)
chr3_+_69216747	0.368	NM_006407	ARL6IP5	ADP-ribosylation-like factor 6 interacting protein 5
chr20_+_8997660	0.364	NM_001172646	PLCB4	phospholipase C, beta 4
chr9_+_35528890	0.363		RUSC2	RUN and SH3 domain containing 2
chr4_+_77575276	0.361	NM_020859	SHROOM3	shroom family member 3
chr15_-_56093477	0.360	NM_170697	ALDH1A2	aldehyde dehydrogenase 1 family, member A2
chr18_-_16945613	0.360		ROCK1	Rho-associated, coiled-coil containing protein kinase 1
chr13_+_92677012	0.359	NM_005708	GPC6	glypican 6
chr5_+_10406802	0.359	NM_005885	MARCH6	membrane-associated ring finger (C3HC4) 6
chr10_+_116843108	0.358	NM_207303	ATRNL1	attractin-like 1
chr5_+_10406980	0.352
chr12_+_102505180	0.351	NM_017564	STAB2	stabilin 2
chr16_+_24475129	0.351		RBBP6	retinoblastoma binding protein 6
chr6_-_11490487	0.350	NM_001142393	NEDD9	neural precursor cell expressed, developmentally down-regulated 9
chr1_+_152229861	0.349	NM_001030	RPS27	ribosomal protein S27
chr5_+_65258250	0.347		ERBB2IP	erbb2 interacting protein
chr12_+_45896511	0.345		FAM113B	family with sequence similarity 113, member B
chr8_-_88955340	0.344	NM_152418	DCAF4L2	DDB1 and CUL4 associated factor 4-like 2
chr1_+_22224571	0.343		HSPC157	hypothetical LOC29092
chr5_+_65258139	0.341	NM_001006600 NM_018695	ERBB2IP	erbb2 interacting protein
chr14_+_64040979	0.341	NM_001123329 NM_014950	ZBTB1	zinc finger and BTB domain containing 1
chr9_+_108665168	0.338	NM_021224	ZNF462	zinc finger protein 462
chr10_+_37454790	0.337	NM_052997	ANKRD30A	ankyrin repeat domain 30A
chr6_+_18495559	0.336	NM_182757	RNF144B	ring finger protein 144B
chr12_-_26877189	0.334	NM_002223	ITPR2	inositol 1,4,5-triphosphate receptor, type 2
chr8_+_9990471	0.333	NM_001135671	MSRA	methionine sulfoxide reductase A
chr2_+_101874765	0.332		MAP4K4	mitogen-activated protein kinase kinase kinase kinase 4
chr5_+_67558217	0.332	NM_181523	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr2_-_202811459	0.331	NM_001005781 NM_001005782 NM_003352	SUMO1	SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)
chr12_-_53071285	0.331	NM_001130967 NM_001130968	ZNF385A	zinc finger protein 385A
chr10_+_106003941	0.330	NM_001191003	GSTO1	glutathione S-transferase omega 1
chr3_-_158695832	0.329	NM_001167917	VEPH1	ventricular zone expressed PH domain homolog 1 (zebrafish)
chr5_+_173247919	0.327	NM_030627	CPEB4	cytoplasmic polyadenylation element binding protein 4
chr4_-_151993422	0.326
chr11_+_22646229	0.325	NM_177553	GAS2	growth arrest-specific 2
chr8_+_7789608	0.324	NM_004942	DEFB4A	defensin, beta 4A
chr2_-_51113040	0.324	NM_001135659 NM_004801	NRXN1	neurexin 1
chr7_+_138566770	0.324	NM_173569	UBN2	ubinuclein 2
chr5_-_10406690	0.324
chr1_+_25629968	0.323	NM_018202	TMEM57	transmembrane protein 57
chr4_-_103968104	0.322	NM_003340 NM_181886 NM_181888 NM_181889	UBE2D3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)
chr1_+_64983312	0.322	NM_018211	RAVER2	ribonucleoprotein, PTB-binding 2
chr17_+_55139792	0.320		VMP1	vacuole membrane protein 1
chr17_+_55139807	0.320		VMP1	vacuole membrane protein 1
chr3_+_197951203	0.319		PAK2	p21 protein (Cdc42/Rac)-activated kinase 2
chr15_-_54175954	0.317		RFX7	regulatory factor X, 7
chr1_-_177378801	0.317	NM_001136000 NM_001168239 NM_005158	ABL2	v-abl Abelson murine leukemia viral oncogene homolog 2
chr2_-_51112743	0.317		NRXN1	neurexin 1
chr17_-_55139538	0.316	NM_016077	PTRH2	peptidyl-tRNA hydrolase 2
chr17_+_55139743	0.316		VMP1	vacuole membrane protein 1
chr1_+_66772393	0.316	NM_032291	SGIP1	SH3-domain GRB2-like (endophilin) interacting protein 1
chr2_-_202192097	0.316		ALS2CR11	amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11
chr7_+_128651976	0.315	NM_001130720 NM_015328	AHCYL2	adenosylhomocysteinase-like 2
chr3_+_87359088	0.314	NM_014043	CHMP2B	chromatin modifying protein 2B
chr2_+_201384505	0.314		BZW1	basic leucine zipper and W2 domains 1
chr14_+_64041257	0.314		ZBTB1	zinc finger and BTB domain containing 1

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.16	1.44e-07	GO:0044260	cellular macromolecule metabolic process
1.24	3.92e-05	GO:0010467	gene expression
1.13	4.26e-05	GO:0043170	macromolecule metabolic process
1.44	1.40e-04	GO:0044265	cellular macromolecule catabolic process
1.22	7.36e-04	GO:0016070	RNA metabolic process
1.42	7.82e-04	GO:0070727	cellular macromolecule localization
1.41	1.39e-03	GO:0034613	cellular protein localization
1.37	3.09e-03	GO:0009057	macromolecule catabolic process
1.62	3.23e-03	GO:0033365	protein localization to organelle
1.17	4.61e-03	GO:0044267	cellular protein metabolic process
1.18	7.81e-03	GO:0090304	nucleic acid metabolic process
1.44	8.99e-03	GO:0006397	mRNA processing
1.37	9.10e-03	GO:0016071	mRNA metabolic process
1.26	1.15e-02	GO:0008104	protein localization
1.34	1.22e-02	GO:0006396	RNA processing
1.46	1.98e-02	GO:0051603	proteolysis involved in cellular protein catabolic process
1.46	2.17e-02	GO:0043632	modification-dependent macromolecule catabolic process
1.42	2.39e-02	GO:0006886	intracellular protein transport
1.09	2.46e-02	GO:0044237	cellular metabolic process
1.46	2.71e-02	GO:0019941	modification-dependent protein catabolic process
1.46	2.97e-02	GO:0006511	ubiquitin-dependent protein catabolic process
1.44	3.18e-02	GO:0044257	cellular protein catabolic process
1.14	4.61e-02	GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.07	1.11e-09	GO:0005622	intracellular
1.08	9.66e-09	GO:0043229	intracellular organelle
1.07	9.74e-09	GO:0044424	intracellular part
1.08	1.23e-08	GO:0043226	organelle
1.09	2.66e-08	GO:0043231	intracellular membrane-bounded organelle
1.09	2.84e-08	GO:0043227	membrane-bounded organelle
1.11	3.06e-05	GO:0044446	intracellular organelle part
1.11	4.19e-05	GO:0044422	organelle part
1.03	9.89e-05	GO:0044464	cell part
1.03	1.06e-04	GO:0005623	cell
1.11	1.76e-04	GO:0005634	nucleus
1.40	2.66e-04	GO:0030529	ribonucleoprotein complex
1.07	2.98e-04	GO:0005737	cytoplasm
1.10	3.21e-04	GO:0044444	cytoplasmic part
1.18	1.12e-03	GO:0044428	nuclear part
1.13	1.75e-03	GO:0032991	macromolecular complex
1.76	2.64e-03	GO:0016607	nuclear speck
1.15	8.44e-03	GO:0031974	membrane-enclosed lumen
1.17	1.45e-02	GO:0031981	nuclear lumen
1.16	2.00e-02	GO:0005829	cytosol
1.64	2.39e-02	GO:0005681	spliceosomal complex
1.48	3.58e-02	GO:0016604	nuclear body
2.02	3.61e-02	GO:0035770	RNA granule
1.14	3.64e-02	GO:0043233	organelle lumen

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.10	1.62e-06	GO:0005515	protein binding
1.05	6.77e-04	GO:0005488	binding
1.30	9.38e-04	GO:0003723	RNA binding
1.31	2.07e-03	GO:0019899	enzyme binding
1.50	1.92e-02	GO:0019900	kinase binding