Motif ID: SPIB.p2

Z-value: 1.380


Transcription factors associated with SPIB.p2:

Gene SymbolEntrez IDGene Name
SPIB 6689 Spi-B transcription factor (Spi-1/PU.1 related)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SPIBchr19_+_55614006-0.581.8e-02Click!


Activity profile for motif SPIB.p2.

activity profile for motif SPIB.p2


Sorted Z-values histogram for motif SPIB.p2

Sorted Z-values for motif SPIB.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPIB.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_30875297 2.809 NM_014268
 MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr3_+_180348818 1.952 NM_006218
 PIK3CA
phosphoinositide-3-kinase, catalytic, alpha polypeptide
chr6_+_130381408 1.486 NM_001007102
NM_032438
 L3MBTL3

l(3)mbt-like 3 (Drosophila)

chr5_+_139485703 1.316 NM_001007189
 C5orf53
chromosome 5 open reading frame 53
chr13_-_32678142 1.114 NM_052851
 STARD13
StAR-related lipid transfer (START) domain containing 13
chr11_+_86426518 1.095 NM_001168724
NM_022918
 TMEM135

transmembrane protein 135

chr2_+_36436873 0.950 NM_016441
 CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr4_+_152417774 0.945 NM_183375
 PRSS48
protease, serine, 48
chr6_+_12398514 0.935 NM_001168319
NM_001955
 EDN1

endothelin 1

chr8_+_64243741 0.907 YTHDF3
YTH domain family, member 3
chr8_+_64243662 0.904 NM_152758
 YTHDF3
YTH domain family, member 3
chr6_+_144040751 0.876 NM_001100164
NM_001100165
 PHACTR2

phosphatase and actin regulator 2

chr6_+_7052798 0.848 NM_001168344
 RREB1
ras responsive element binding protein 1
chr14_+_99601498 0.844 NM_016337
 EVL
Enah/Vasp-like
chr20_-_48980858 0.841 NM_015339
NM_181442
 ADNP

activity-dependent neuroprotector homeobox

chr1_-_205272619 0.780 NM_001083924
NM_023938
 C1orf116

chromosome 1 open reading frame 116

chr1_+_158636987 0.767 NM_020335
 VANGL2
vang-like 2 (van gogh, Drosophila)
chr7_-_104440707 0.765 LOC100216545
hypothetical LOC100216545
chr6_+_7053183 0.732 RREB1
ras responsive element binding protein 1
chr20_-_2031521 0.727



Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 23 entries
enrichment   p-value GO term description
1.62 3.23e-03 GO:0033365 protein localization to organelle
1.46 1.98e-02 GO:0051603 proteolysis involved in cellular protein catabolic process
1.46 2.17e-02 GO:0043632 modification-dependent macromolecule catabolic process
1.46 2.71e-02 GO:0019941 modification-dependent protein catabolic process
1.46 2.97e-02 GO:0006511 ubiquitin-dependent protein catabolic process
1.44 1.40e-04 GO:0044265 cellular macromolecule catabolic process
1.44 8.99e-03 GO:0006397 mRNA processing
1.44 3.18e-02 GO:0044257 cellular protein catabolic process
1.42 7.82e-04 GO:0070727 cellular macromolecule localization
1.42 2.39e-02 GO:0006886 intracellular protein transport
1.41 1.39e-03 GO:0034613 cellular protein localization
1.37 3.09e-03 GO:0009057 macromolecule catabolic process
1.37 9.10e-03 GO:0016071 mRNA metabolic process
1.34 1.22e-02 GO:0006396 RNA processing
1.26 1.15e-02 GO:0008104 protein localization
1.24 3.92e-05 GO:0010467 gene expression
1.22 7.36e-04 GO:0016070 RNA metabolic process
1.18 7.81e-03 GO:0090304 nucleic acid metabolic process
1.17 4.61e-03 GO:0044267 cellular protein metabolic process
1.16 1.44e-07 GO:0044260 cellular macromolecule metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 24 entries
enrichment   p-value GO term description
2.02 3.61e-02 GO:0035770 RNA granule
1.76 2.64e-03 GO:0016607 nuclear speck
1.64 2.39e-02 GO:0005681 spliceosomal complex
1.48 3.58e-02 GO:0016604 nuclear body
1.40 2.66e-04 GO:0030529 ribonucleoprotein complex
1.18 1.12e-03 GO:0044428 nuclear part
1.17 1.45e-02 GO:0031981 nuclear lumen
1.16 2.00e-02 GO:0005829 cytosol
1.15 8.44e-03 GO:0031974 membrane-enclosed lumen
1.14 3.64e-02 GO:0043233 organelle lumen
1.13 1.75e-03 GO:0032991 macromolecular complex
1.11 3.06e-05 GO:0044446 intracellular organelle part
1.11 4.19e-05 GO:0044422 organelle part
1.11 1.76e-04 GO:0005634 nucleus
1.10 3.21e-04 GO:0044444 cytoplasmic part
1.09 2.66e-08 GO:0043231 intracellular membrane-bounded organelle
1.09 2.84e-08 GO:0043227 membrane-bounded organelle
1.08 9.66e-09 GO:0043229 intracellular organelle
1.08 1.23e-08 GO:0043226 organelle
1.07 1.11e-09 GO:0005622 intracellular

Gene overrepresentation in function category:

Showing 1 to 5 of 5 entries
enrichment   p-value GO term description
1.50 1.92e-02 GO:0019900 kinase binding
1.31 2.07e-03 GO:0019899 enzyme binding
1.30 9.38e-04 GO:0003723 RNA binding
1.10 1.62e-06 GO:0005515 protein binding
1.05 6.77e-04 GO:0005488 binding