Motif ID: SPIB.p2

Z-value: 1.380


Transcription factors associated with SPIB.p2:

Gene SymbolEntrez IDGene Name
SPIB 6689 Spi-B transcription factor (Spi-1/PU.1 related)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SPIBchr19_+_55614006-0.581.8e-02Click!


Activity profile for motif SPIB.p2.

activity profile for motif SPIB.p2


Sorted Z-values histogram for motif SPIB.p2

Sorted Z-values for motif SPIB.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPIB.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_+_30875297 2.809 NM_014268
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr3_+_180348818 1.952 NM_006218
PIK3CA
phosphoinositide-3-kinase, catalytic, alpha polypeptide
chr6_+_130381408 1.486 NM_001007102
NM_032438
L3MBTL3

l(3)mbt-like 3 (Drosophila)

chr5_+_139485703 1.316 NM_001007189
C5orf53
chromosome 5 open reading frame 53
chr13_-_32678142 1.114 NM_052851
STARD13
StAR-related lipid transfer (START) domain containing 13
chr11_+_86426518 1.095 NM_001168724
NM_022918
TMEM135

transmembrane protein 135

chr2_+_36436873 0.950 NM_016441
CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr4_+_152417774 0.945 NM_183375
PRSS48
protease, serine, 48
chr6_+_12398514 0.935 NM_001168319
NM_001955
EDN1

endothelin 1

chr8_+_64243741 0.907 YTHDF3
YTH domain family, member 3
chr8_+_64243662 0.904 NM_152758
YTHDF3
YTH domain family, member 3
chr6_+_144040751 0.876 NM_001100164
NM_001100165
PHACTR2

phosphatase and actin regulator 2

chr6_+_7052798 0.848 NM_001168344
RREB1
ras responsive element binding protein 1
chr14_+_99601498 0.844 NM_016337
EVL
Enah/Vasp-like
chr20_-_48980858 0.841 NM_015339
NM_181442
ADNP

activity-dependent neuroprotector homeobox

chr1_-_205272619 0.780 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr1_+_158636987 0.767 NM_020335
VANGL2
vang-like 2 (van gogh, Drosophila)
chr7_-_104440707 0.765 LOC100216545
hypothetical LOC100216545
chr6_+_7053183 0.732 RREB1
ras responsive element binding protein 1
chr20_-_2031521 0.727


chr8_+_28803804 0.724 NM_001135726
HMBOX1
homeobox containing 1
chr2_-_175207521 0.715 NM_003387
WIPF1
WAS/WASL interacting protein family, member 1
chr2_-_21084911 0.712 APOB
apolipoprotein B (including Ag(x) antigen)
chr14_+_99601517 0.711 EVL
Enah/Vasp-like
chr12_-_26166485 0.703 BHLHE41
basic helix-loop-helix family, member e41
chr16_+_24696069 0.690 TNRC6A
trinucleotide repeat containing 6A
chr11_-_9182356 0.690 DENND5A
DENN/MADD domain containing 5A
chr3_+_153499883 0.690 NM_207293
NM_207294
NM_207295
NM_207296
NM_207297
MBNL1




muscleblind-like (Drosophila)




chr8_-_28803341 0.689 NM_001172562
INTS9
integrator complex subunit 9
chr8_-_28803616 0.670 NM_001145159
NM_018250
INTS9

integrator complex subunit 9

chr17_+_24742068 0.670 NM_020791
TAOK1
TAO kinase 1
chr3_+_120495906 0.665 NM_020754
ARHGAP31
Rho GTPase activating protein 31
chr4_+_87070449 0.628 NM_031305
ARHGAP24
Rho GTPase activating protein 24
chr1_+_27972269 0.627 NM_177424
STX12
syntaxin 12
chr20_+_2031418 0.614 STK35
serine/threonine kinase 35
chr5_+_10406829 0.611 MARCH6
membrane-associated ring finger (C3HC4) 6
chr6_+_7052985 0.608 NM_001003698
NM_001003699
NM_001003700
RREB1


ras responsive element binding protein 1


chr2_+_149118791 0.606 EPC2
enhancer of polycomb homolog 2 (Drosophila)
chr2_+_155263338 0.606 NM_002239
KCNJ3
potassium inwardly-rectifying channel, subfamily J, member 3
chr14_+_38720085 0.605 PNN
pinin, desmosome associated protein
chr17_+_44643067 0.604 ABI3
ABI family, member 3
chr16_+_31105579 0.599


chr9_+_119506446 0.597 TLR4
toll-like receptor 4
chr9_+_119506274 0.592 NM_138554
TLR4
toll-like receptor 4
chr12_-_70953461 0.590 LOC283392
hypothetical LOC283392
chr3_+_138020550 0.579 NM_001097599
NM_001097600
NM_025246
TMEM22


transmembrane protein 22


chr12_-_11215396 0.579 NM_001098538
NM_006250
PRH1-PRR4
PRR4
TAS2R14
PRH1
PRH1-PRR4 read-through transcript
proline rich 4 (lacrimal)
taste receptor, type 2, member 14
proline-rich protein HaeIII subfamily 1
chr14_-_20969706 0.572 NM_001170629
CHD8
chromodomain helicase DNA binding protein 8
chr2_+_46779553 0.561 NM_014011
SOCS5
suppressor of cytokine signaling 5
chr3_+_98966253 0.555 NM_032146
NM_177976
ARL6

ADP-ribosylation factor-like 6

chr15_+_94676691 0.551 NM_001145156
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr17_-_36376663 0.550 NM_213656
KRT39
keratin 39
chr13_+_44937025 0.549 NM_031431
COG3
component of oligomeric golgi complex 3
chr9_+_114289178 0.546 KIAA1958
KIAA1958
chr9_+_119506428 0.542 TLR4
toll-like receptor 4
chr6_-_56816403 0.540 DST
dystonin
chr15_+_55298908 0.522 NM_207040
TCF12
transcription factor 12
chr1_-_181826633 0.521 NM_001127651
NCF2
neutrophil cytosolic factor 2
chr5_+_52131686 0.515 PELO
pelota homolog (Drosophila)
chr3_+_101811122 0.509 NM_032787
GPR128
G protein-coupled receptor 128
chr5_-_32439067 0.505 ZFR
zinc finger RNA binding protein
chr3_+_195889845 0.502 FAM43A
family with sequence similarity 43, member A
chr12_+_95112385 0.501 ELK3
ELK3, ETS-domain protein (SRF accessory protein 2)
chr6_+_21701942 0.497 NM_003107
SOX4
SRY (sex determining region Y)-box 4
chr10_+_31647425 0.496 ZEB1
zinc finger E-box binding homeobox 1
chr6_+_153060722 0.496 NM_025107
MYCT1
myc target 1
chr2_-_160838397 0.491 RBMS1
RNA binding motif, single stranded interacting protein 1
chr17_+_63252704 0.491 BPTF
bromodomain PHD finger transcription factor
chr22_+_39818553 0.490 NM_001429
EP300
E1A binding protein p300
chr5_+_132237253 0.489 NM_052971
LEAP2
liver expressed antimicrobial peptide 2
chr18_-_16945763 0.486 NM_005406
ROCK1
Rho-associated, coiled-coil containing protein kinase 1
chr12_-_23995109 0.485 SOX5
SRY (sex determining region Y)-box 5
chr11_+_8660913 0.483 RPL27A
ribosomal protein L27a
chr14_-_21074875 0.479 NM_005407
SALL2
sal-like 2 (Drosophila)
chr4_+_91035025 0.477 NM_007351
MMRN1
multimerin 1
chr2_+_118562499 0.476 NM_016133
INSIG2
insulin induced gene 2
chr20_+_42947754 0.476 NM_003404
NM_139323
YWHAB

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide

chr14_+_54104099 0.472 SAMD4A
sterile alpha motif domain containing 4A
chr7_+_86619580 0.472 NM_001142326
NM_001142327
DMTF1

cyclin D binding myb-like transcription factor 1

chr20_+_42947764 0.471 YWHAB
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
chr1_+_93317374 0.471 NM_001164391
NM_001164392
NM_001164393
NM_007358
MTF2



metal response element binding transcription factor 2



chr15_+_72620570 0.471 NM_006465
ARID3B
AT rich interactive domain 3B (BRIGHT-like)
chr4_-_174557191 0.469 NM_007281
SCRG1
stimulator of chondrogenesis 1
chr2_-_55090759 0.466 NM_007008
RTN4
reticulon 4
chr1_+_13948448 0.464 NM_001007257
PRDM2
PR domain containing 2, with ZNF domain
chr13_+_98951772 0.463 TM9SF2
transmembrane 9 superfamily member 2
chr5_+_52119442 0.459 NM_181501
NM_015946
ITGA1
PELO
integrin, alpha 1
pelota homolog (Drosophila)
chr11_+_64950074 0.453 NEAT1
nuclear paraspeckle assembly transcript 1 (non-protein coding)
chr5_+_36912656 0.452 NIPBL
Nipped-B homolog (Drosophila)
chr10_+_17312654 0.450 VIM
vimentin
chr4_+_109761170 0.449 NM_000995
NM_033625
RPL34

ribosomal protein L34

chr9_+_102244005 0.445 NM_001198812
C9orf3-TMEFF1
C9orf30
C9orf3-TMEFF1 readthrough
chromosome 9 open reading frame 30
chr1_+_183970093 0.440 NM_031935
HMCN1
hemicentin 1
chr16_-_70306198 0.438 NM_015020
PHLPP2
PH domain and leucine rich repeat protein phosphatase 2
chr14_-_24047261 0.437 NM_001836
CMA1
chymase 1, mast cell
chr14_+_23937766 0.435 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr5_+_79739548 0.435 NM_001105251
NM_014733
ZFYVE16

zinc finger, FYVE domain containing 16

chr8_-_82522175 0.434 NM_002677
PMP2
peripheral myelin protein 2
chr2_+_36436316 0.433 CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr6_-_32268267 0.432 GPSM3
G-protein signaling modulator 3
chr3_+_120496180 0.431 ARHGAP31
Rho GTPase activating protein 31
chr10_+_18988282 0.430 NM_178815
ARL5B
ADP-ribosylation factor-like 5B
chr10_-_18988172 0.430


chr3_-_107070400 0.426 NM_170662
CBLB
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
chr5_-_58370693 0.422 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chr10_-_27189898 0.421 ABI1
abl-interactor 1
chr6_+_7053863 0.420 RREB1
ras responsive element binding protein 1
chr14_+_49157150 0.419 NM_002408
MGAT2
mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr2_+_149119029 0.419 NM_015630
EPC2
enhancer of polycomb homolog 2 (Drosophila)
chr8_+_90983934 0.411 NM_001126111
OSGIN2
oxidative stress induced growth inhibitor family member 2
chr20_+_13924263 0.406 MACROD2
MACRO domain containing 2
chr2_+_64604940 0.406 NM_001002243
NM_017657
NM_203437
AFTPH


aftiphilin


chr2_+_54638957 0.404 NM_178313
SPTBN1
spectrin, beta, non-erythrocytic 1
chr3_+_114948550 0.403 NM_001690
ATP6V1A
ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr20_+_30409649 0.402 NM_001164603
NM_015338
ASXL1

additional sex combs like 1 (Drosophila)

chr8_-_38245694 0.402 NM_001102559
NM_001102560
NM_032483
PPAPDC1B


phosphatidic acid phosphatase type 2 domain containing 1B


chr11_-_5419358 0.400 NM_001005288
OR51I1
olfactory receptor, family 51, subfamily I, member 1
chr1_+_36169260 0.399 NM_024852
NM_177422
EIF2C3

eukaryotic translation initiation factor 2C, 3

chr14_+_64041170 0.398 ZBTB1
zinc finger and BTB domain containing 1
chr13_+_98951653 0.396 NM_004800
TM9SF2
transmembrane 9 superfamily member 2
chr21_-_30614477 0.394 NM_203405
KRTAP26-1
keratin associated protein 26-1
chr5_-_54504590 0.393 NM_001145734
NM_001170402
NM_152623
CDC20B


cell division cycle 20 homolog B (S. cerevisiae)


chr17_+_63252668 0.393 BPTF
bromodomain PHD finger transcription factor
chr6_+_47732181 0.392 NM_153839
GPR111
G protein-coupled receptor 111
chr12_-_15005761 0.390 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr3_-_69674412 0.390 FRMD4B
FERM domain containing 4B
chr22_-_34566210 0.388 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr2_+_187162969 0.387 NM_001145000
NM_002210
ITGAV

integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)

chr12_+_51686512 0.386 EIF4B
eukaryotic translation initiation factor 4B
chr2_-_47986160 0.384 NM_001190274
FBXO11
F-box protein 11
chr1_+_246635918 0.384 NM_030904
OR2T1
olfactory receptor, family 2, subfamily T, member 1
chr22_-_34566367 0.384 NM_001031695
NM_001082576
NM_001082577
NM_014309
RBFOX2



RNA binding protein, fox-1 homolog (C. elegans) 2



chr3_+_99934227 0.384 NM_006100
ST3GAL6
ST3 beta-galactoside alpha-2,3-sialyltransferase 6
chr20_-_42249631 0.383 NM_020433
NM_175913
JPH2

junctophilin 2

chr2_-_213723298 0.381 NM_016260
IKZF2
IKAROS family zinc finger 2 (Helios)
chr5_+_112340326 0.380 NM_152624
DCP2
DCP2 decapping enzyme homolog (S. cerevisiae)
chr16_-_65781499 0.379 NM_178516
EXOC3L1
exocyst complex component 3-like 1
chr11_+_64950402 0.379


chr9_+_114288899 0.375 NM_133465
KIAA1958
KIAA1958
chr1_+_182040837 0.375 RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr1_+_26896519 0.374 ARID1A
AT rich interactive domain 1A (SWI-like)
chr6_+_57290357 0.371 NM_000947
PRIM2
primase, DNA, polypeptide 2 (58kDa)
chr22_-_34566276 0.370 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr3_-_114176401 0.370 NM_138806
NM_138939
NM_138940
NM_170780
CD200R1



CD200 receptor 1



chr7_+_37926943 0.369 EPDR1
ependymin related protein 1 (zebrafish)
chr3_+_69216747 0.368 NM_006407
ARL6IP5
ADP-ribosylation-like factor 6 interacting protein 5
chr20_+_8997660 0.364 NM_001172646
PLCB4
phospholipase C, beta 4
chr9_+_35528890 0.363 RUSC2
RUN and SH3 domain containing 2
chr4_+_77575276 0.361 NM_020859
SHROOM3
shroom family member 3
chr15_-_56093477 0.360 NM_170697
ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr18_-_16945613 0.360 ROCK1
Rho-associated, coiled-coil containing protein kinase 1
chr13_+_92677012 0.359 NM_005708
GPC6
glypican 6
chr5_+_10406802 0.359 NM_005885
MARCH6
membrane-associated ring finger (C3HC4) 6
chr10_+_116843108 0.358 NM_207303
ATRNL1
attractin-like 1
chr5_+_10406980 0.352


chr12_+_102505180 0.351 NM_017564
STAB2
stabilin 2
chr16_+_24475129 0.351 RBBP6
retinoblastoma binding protein 6
chr6_-_11490487 0.350 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr1_+_152229861 0.349 NM_001030
RPS27
ribosomal protein S27
chr5_+_65258250 0.347 ERBB2IP
erbb2 interacting protein
chr12_+_45896511 0.345 FAM113B
family with sequence similarity 113, member B
chr8_-_88955340 0.344 NM_152418
DCAF4L2
DDB1 and CUL4 associated factor 4-like 2
chr1_+_22224571 0.343 HSPC157
hypothetical LOC29092
chr5_+_65258139 0.341 NM_001006600
NM_018695
ERBB2IP

erbb2 interacting protein

chr14_+_64040979 0.341 NM_001123329
NM_014950
ZBTB1

zinc finger and BTB domain containing 1

chr9_+_108665168 0.338 NM_021224
ZNF462
zinc finger protein 462
chr10_+_37454790 0.337 NM_052997
ANKRD30A
ankyrin repeat domain 30A
chr6_+_18495559 0.336 NM_182757
RNF144B
ring finger protein 144B
chr12_-_26877189 0.334 NM_002223
ITPR2
inositol 1,4,5-triphosphate receptor, type 2
chr8_+_9990471 0.333 NM_001135671
MSRA
methionine sulfoxide reductase A
chr2_+_101874765 0.332 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr5_+_67558217 0.332 NM_181523
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr2_-_202811459 0.331 NM_001005781
NM_001005782
NM_003352
SUMO1


SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)


chr12_-_53071285 0.331 NM_001130967
NM_001130968
ZNF385A

zinc finger protein 385A

chr10_+_106003941 0.330 NM_001191003
GSTO1
glutathione S-transferase omega 1
chr3_-_158695832 0.329 NM_001167917
VEPH1
ventricular zone expressed PH domain homolog 1 (zebrafish)
chr5_+_173247919 0.327 NM_030627
CPEB4
cytoplasmic polyadenylation element binding protein 4
chr4_-_151993422 0.326


chr11_+_22646229 0.325 NM_177553
GAS2
growth arrest-specific 2
chr8_+_7789608 0.324 NM_004942
DEFB4A
defensin, beta 4A
chr2_-_51113040 0.324 NM_001135659
NM_004801
NRXN1

neurexin 1

chr7_+_138566770 0.324 NM_173569
UBN2
ubinuclein 2
chr5_-_10406690 0.324


chr1_+_25629968 0.323 NM_018202
TMEM57
transmembrane protein 57
chr4_-_103968104 0.322 NM_003340
NM_181886
NM_181888
NM_181889
UBE2D3



ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)



chr1_+_64983312 0.322 NM_018211
RAVER2
ribonucleoprotein, PTB-binding 2
chr17_+_55139792 0.320 VMP1
vacuole membrane protein 1
chr17_+_55139807 0.320 VMP1
vacuole membrane protein 1
chr3_+_197951203 0.319 PAK2
p21 protein (Cdc42/Rac)-activated kinase 2
chr15_-_54175954 0.317 RFX7
regulatory factor X, 7
chr1_-_177378801 0.317 NM_001136000
NM_001168239
NM_005158
ABL2


v-abl Abelson murine leukemia viral oncogene homolog 2


chr2_-_51112743 0.317 NRXN1
neurexin 1
chr17_-_55139538 0.316 NM_016077
PTRH2
peptidyl-tRNA hydrolase 2
chr17_+_55139743 0.316 VMP1
vacuole membrane protein 1
chr1_+_66772393 0.316 NM_032291
SGIP1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr2_-_202192097 0.316 ALS2CR11
amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11
chr7_+_128651976 0.315 NM_001130720
NM_015328
AHCYL2

adenosylhomocysteinase-like 2

chr3_+_87359088 0.314 NM_014043
CHMP2B
chromatin modifying protein 2B
chr2_+_201384505 0.314 BZW1
basic leucine zipper and W2 domains 1
chr14_+_64041257 0.314 ZBTB1
zinc finger and BTB domain containing 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.16 1.44e-07 GO:0044260 cellular macromolecule metabolic process
1.24 3.92e-05 GO:0010467 gene expression
1.13 4.26e-05 GO:0043170 macromolecule metabolic process
1.44 1.40e-04 GO:0044265 cellular macromolecule catabolic process
1.22 7.36e-04 GO:0016070 RNA metabolic process
1.42 7.82e-04 GO:0070727 cellular macromolecule localization
1.41 1.39e-03 GO:0034613 cellular protein localization
1.37 3.09e-03 GO:0009057 macromolecule catabolic process
1.62 3.23e-03 GO:0033365 protein localization to organelle
1.17 4.61e-03 GO:0044267 cellular protein metabolic process
1.18 7.81e-03 GO:0090304 nucleic acid metabolic process
1.44 8.99e-03 GO:0006397 mRNA processing
1.37 9.10e-03 GO:0016071 mRNA metabolic process
1.26 1.15e-02 GO:0008104 protein localization
1.34 1.22e-02 GO:0006396 RNA processing
1.46 1.98e-02 GO:0051603 proteolysis involved in cellular protein catabolic process
1.46 2.17e-02 GO:0043632 modification-dependent macromolecule catabolic process
1.42 2.39e-02 GO:0006886 intracellular protein transport
1.09 2.46e-02 GO:0044237 cellular metabolic process
1.46 2.71e-02 GO:0019941 modification-dependent protein catabolic process
1.46 2.97e-02 GO:0006511 ubiquitin-dependent protein catabolic process
1.44 3.18e-02 GO:0044257 cellular protein catabolic process
1.14 4.61e-02 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.07 1.11e-09 GO:0005622 intracellular
1.08 9.66e-09 GO:0043229 intracellular organelle
1.07 9.74e-09 GO:0044424 intracellular part
1.08 1.23e-08 GO:0043226 organelle
1.09 2.66e-08 GO:0043231 intracellular membrane-bounded organelle
1.09 2.84e-08 GO:0043227 membrane-bounded organelle
1.11 3.06e-05 GO:0044446 intracellular organelle part
1.11 4.19e-05 GO:0044422 organelle part
1.03 9.89e-05 GO:0044464 cell part
1.03 1.06e-04 GO:0005623 cell
1.11 1.76e-04 GO:0005634 nucleus
1.40 2.66e-04 GO:0030529 ribonucleoprotein complex
1.07 2.98e-04 GO:0005737 cytoplasm
1.10 3.21e-04 GO:0044444 cytoplasmic part
1.18 1.12e-03 GO:0044428 nuclear part
1.13 1.75e-03 GO:0032991 macromolecular complex
1.76 2.64e-03 GO:0016607 nuclear speck
1.15 8.44e-03 GO:0031974 membrane-enclosed lumen
1.17 1.45e-02 GO:0031981 nuclear lumen
1.16 2.00e-02 GO:0005829 cytosol
1.64 2.39e-02 GO:0005681 spliceosomal complex
1.48 3.58e-02 GO:0016604 nuclear body
2.02 3.61e-02 GO:0035770 RNA granule
1.14 3.64e-02 GO:0043233 organelle lumen

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.10 1.62e-06 GO:0005515 protein binding
1.05 6.77e-04 GO:0005488 binding
1.30 9.38e-04 GO:0003723 RNA binding
1.31 2.07e-03 GO:0019899 enzyme binding
1.50 1.92e-02 GO:0019900 kinase binding