Motif ID: SRF.p3

Z-value: 1.822


Transcription factors associated with SRF.p3:

Gene SymbolEntrez IDGene Name
SRF 6722 serum response factor (c-fos serum response element-binding transcription factor)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SRFchr6_+_43247168-0.039.1e-01Click!


Activity profile for motif SRF.p3.

activity profile for motif SRF.p3


Sorted Z-values histogram for motif SRF.p3

Sorted Z-values for motif SRF.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of SRF.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_137829065 17.380 EGR1
early growth response 1
chr5_+_137829077 15.395 NM_001964
 EGR1
early growth response 1
chr17_+_30498948 4.316 NM_001033576
NM_173167
 UNC45B

unc-45 homolog B (C. elegans)

chr10_-_64246129 3.720 NM_000399
NM_001136177
NM_001136179
 EGR2


early growth response 2


chr20_+_34603290 3.599 NM_006097
NM_181526
 MYL9

myosin, light chain 9, regulatory

chr12_+_50731457 3.181 NM_002135
NM_173157
 NR4A1

nuclear receptor subfamily 4, group A, member 1

chr20_+_34603311 3.057 MYL9
myosin, light chain 9, regulatory
chr12_+_52713098 2.852 NM_018953
 HOXC5
homeobox C5
chr10_-_64246080 2.460 EGR2
early growth response 2
chr19_+_2427122 2.435 NM_015675
 GADD45B
growth arrest and DNA-damage-inducible, beta
chr10_+_112247614 2.427 NM_004419
 DUSP5
dual specificity phosphatase 5
chr9_+_91409746 2.175 NM_006705
 GADD45G
growth arrest and DNA-damage-inducible, gamma
chr1_+_6226838 2.100 NM_001024598
 HES3
hairy and enhancer of split 3 (Drosophila)
chr3_-_46879883 2.073 NM_000258
 MYL3
myosin, light chain 3, alkali; ventricular, skeletal, slow
chr22_+_29810981 1.973 SMTN
smoothelin
chr2_+_73973600 1.964 NM_001615
 ACTG2
actin, gamma 2, smooth muscle, enteric
chr2_-_30883775 1.889 NM_144575
 CAPN13
calpain 13
chr20_-_21442663 1.788 NM_002509
 NKX2-2
NK2 homeobox 2
chr2_+_73973640 1.764 ACTG2
actin, gamma 2, smooth muscle, enteric
chr19_+_12995782 1.723 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 41 entries
enrichment   p-value GO term description
12.70 1.16e-03 GO:0070252 actin-mediated cell contraction
12.17 4.82e-05 GO:0030048 actin filament-based movement
11.18 1.52e-02 GO:0030049 muscle filament sliding
11.18 1.52e-02 GO:0033275 actin-myosin filament sliding
7.26 1.54e-02 GO:0007015 actin filament organization
6.55 1.12e-05 GO:0006936 muscle contraction
6.02 3.54e-05 GO:0003012 muscle system process
5.97 2.23e-02 GO:0032970 regulation of actin filament-based process
5.09 3.20e-06 GO:0030029 actin filament-based process
4.87 3.25e-03 GO:0007517 muscle organ development
4.13 9.40e-03 GO:0030036 actin cytoskeleton organization
3.73 2.93e-02 GO:0061061 muscle structure development
3.11 2.48e-02 GO:0032583 regulation of gene-specific transcription
2.94 1.04e-03 GO:0010628 positive regulation of gene expression
2.90 3.88e-02 GO:0007010 cytoskeleton organization
2.64 4.95e-03 GO:0051173 positive regulation of nitrogen compound metabolic process
2.56 1.86e-02 GO:0010557 positive regulation of macromolecule biosynthetic process
2.52 2.50e-02 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.51 1.83e-03 GO:0006357 regulation of transcription from RNA polymerase II promoter
2.51 8.42e-03 GO:0009891 positive regulation of biosynthetic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 20 entries
enrichment   p-value GO term description
21.21 4.91e-03 GO:0031672 A band
19.15 8.00e-04 GO:0005859 muscle myosin complex
17.24 1.41e-03 GO:0016460 myosin II complex
13.79 6.88e-04 GO:0032432 actin filament bundle
12.31 8.14e-03 GO:0001725 stress fiber
12.17 1.48e-03 GO:0005884 actin filament
10.45 1.85e-02 GO:0042641 actomyosin
9.70 6.03e-05 GO:0016459 myosin complex
8.54 1.75e-07 GO:0044449 contractile fiber part
8.41 5.47e-08 GO:0043292 contractile fiber
8.32 2.48e-07 GO:0030016 myofibril
7.74 3.17e-05 GO:0030017 sarcomere
6.97 3.09e-04 GO:0005925 focal adhesion
6.63 4.86e-04 GO:0005924 cell-substrate adherens junction
6.39 6.85e-04 GO:0030055 cell-substrate junction
6.27 1.61e-11 GO:0015629 actin cytoskeleton
4.63 1.15e-02 GO:0005912 adherens junction
4.18 2.68e-02 GO:0070161 anchoring junction
2.14 1.56e-04 GO:0005856 cytoskeleton
2.13 1.10e-02 GO:0044430 cytoskeletal part

Gene overrepresentation in function category:

Showing 1 to 12 of 12 entries
enrichment   p-value GO term description
14.43 2.02e-06 GO:0008307 structural constituent of muscle
13.79 5.72e-03 GO:0017022 myosin binding
7.66 1.59e-04 GO:0003704 specific RNA polymerase II transcription factor activity
5.02 5.31e-08 GO:0003779 actin binding
3.65 1.46e-02 GO:0003702 RNA polymerase II transcription factor activity
3.47 8.65e-06 GO:0008092 cytoskeletal protein binding
2.68 2.81e-03 GO:0046983 protein dimerization activity
2.61 2.99e-05 GO:0030528 transcription regulator activity
2.45 1.67e-02 GO:0043565 sequence-specific DNA binding
2.44 4.72e-04 GO:0001071 nucleic acid binding transcription factor activity
2.44 4.72e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
1.36 7.25e-04 GO:0005515 protein binding