Motif ID: STAT2,4,6.p2

Z-value: 1.321


Transcription factors associated with STAT2,4,6.p2:

Gene SymbolEntrez IDGene Name
STAT2 6773 signal transducer and activator of transcription 2, 113kDa
STAT4 6775 signal transducer and activator of transcription 4
STAT6 6778 signal transducer and activator of transcription 6, interleukin-4 induced

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
STAT6chr12_-_557913880.391.4e-01Click!
STAT4chr2_-_1917239960.214.4e-01Click!
STAT2chr12_-_55040179-0.058.5e-01Click!


Activity profile for motif STAT2,4,6.p2.

activity profile for motif STAT2,4,6.p2


Sorted Z-values histogram for motif STAT2,4,6.p2

Sorted Z-values for motif STAT2,4,6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT2,4,6.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_-_126706442 1.586 NM_022802
CTBP2
C-terminal binding protein 2
chr19_+_49248003 1.124 NM_013361
ZNF223
zinc finger protein 223
chr5_+_57914658 0.903 NM_138453
RAB3C
RAB3C, member RAS oncogene family
chr11_-_27637771 0.883 NM_001143816
NM_170735
BDNF

brain-derived neurotrophic factor

chr12_-_41164052 0.811 NM_001144882
NM_001144883
PRICKLE1

prickle homolog 1 (Drosophila)

chr19_+_49361054 0.784 NM_001146220
NM_001032373
NM_001032374
NM_015919
NM_001032372
ZNF226




zinc finger protein 226




chr12_-_41164010 0.722 PRICKLE1
prickle homolog 1 (Drosophila)
chr6_+_154373323 0.721 NM_001145279
NM_001145280
NM_001145281
OPRM1


opioid receptor, mu 1


chr13_+_47948586 0.689 RB1
retinoblastoma 1
chr8_-_8276598 0.679 NM_001080826
SGK223
homolog of rat pragma of Rnd2
chr18_+_59295123 0.665 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr12_-_14982708 0.649 NM_152321
ERP27
endoplasmic reticulum protein 27
chr17_+_29606408 0.644 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr3_-_156876798 0.628 NM_001130960
NM_001130961
PLCH1

phospholipase C, eta 1

chr1_+_154178103 0.627 NM_181885
RXFP4
relaxin/insulin-like family peptide receptor 4
chr14_+_52243645 0.625 NM_002806
PSMC6
proteasome (prosome, macropain) 26S subunit, ATPase, 6
chr2_-_79240293 0.621 NM_138938
NM_002580
NM_138937
REG3A


regenerating islet-derived 3 alpha


chr19_-_17377383 0.609 NM_004335
BST2
bone marrow stromal cell antigen 2
chr17_+_55269974 0.608


chr2_+_159533329 0.604 NM_001145909
NM_033394
TANC1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr5_-_92982927 0.589


chr12_-_61283474 0.581 NM_175895
C12orf61
chromosome 12 open reading frame 61
chr12_-_55432348 0.577 NM_000946
PRIM1
primase, DNA, polypeptide 1 (49kDa)
chr7_+_134114912 0.564 CALD1
caldesmon 1
chr13_-_32678142 0.561 NM_052851
STARD13
StAR-related lipid transfer (START) domain containing 13
chr11_-_116168316 0.560 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr7_+_134114957 0.543 CALD1
caldesmon 1
chr3_+_185377341 0.542 AP2M1
adaptor-related protein complex 2, mu 1 subunit
chr12_-_47532171 0.533 NM_004818
DDX23
DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
chr3_+_125296217 0.532 NM_001024660
NM_003947
KALRN

kalirin, RhoGEF kinase

chr12_-_88573949 0.530 NM_001001323
NM_001682
ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

chr5_-_22889487 0.528 NM_004061
CDH12
cadherin 12, type 2 (N-cadherin 2)
chr3_+_99699137 0.517 NM_001004737
OR5K2
olfactory receptor, family 5, subfamily K, member 2
chr11_+_33236435 0.506 HIPK3
homeodomain interacting protein kinase 3
chr5_-_121842680 0.502


chr9_-_88751923 0.499 NM_002048
GAS1
growth arrest-specific 1
chr19_+_58715988 0.490 NM_018555
ZNF331
zinc finger protein 331
chr5_+_178300799 0.483 NM_001178089
NM_001178090
NM_182594
ZNF454


zinc finger protein 454


chr20_-_33580861 0.478 NM_001145350
C20orf173
chromosome 20 open reading frame 173
chr5_-_150501393 0.478 NM_001193544
ANXA6
annexin A6
chr5_-_22889192 0.475 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr3_+_114192489 0.464 NM_014170
NM_138485
GTPBP8

GTP-binding protein 8 (putative)

chr14_-_93988838 0.461 NM_001080451
SERPINA11
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11
chr19_+_42400908 0.458 ZNF383
zinc finger protein 383
chr11_+_4522993 0.457 NM_001004137
OR52M1
olfactory receptor, family 52, subfamily M, member 1
chr1_-_94147574 0.452 NM_002061
GCLM
glutamate-cysteine ligase, modifier subunit
chr14_+_66777578 0.451 NM_022474
MPP5
membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
chr17_-_8215577 0.444 NM_213597
KRBA2
KRAB-A domain containing 2
chr4_-_175986952 0.444 NM_001042543
NM_006529
GLRA3

glycine receptor, alpha 3

chr10_+_129237602 0.442 NM_001030013
NPS
neuropeptide S
chr4_-_155731288 0.439 NM_000508
NM_021871
FGA

fibrinogen alpha chain

chr19_+_62844143 0.439 ZNF211
zinc finger protein 211
chr19_-_49309102 0.439 LOC100379224
hypothetical LOC100379224
chr3_-_50624114 0.434 NM_013324
NM_145071
CISH

cytokine inducible SH2-containing protein

chr3_+_77171938 0.433 NM_002942
ROBO2
roundabout, axon guidance receptor, homolog 2 (Drosophila)
chr4_-_21155376 0.433 NM_001035004
KCNIP4
Kv channel interacting protein 4
chr20_+_39091026 0.429 TOP1
topoisomerase (DNA) I
chr19_-_49552638 0.427 NM_001083335
NM_013380
ZFP112

zinc finger protein 112 homolog (mouse)

chr7_+_89870707 0.425 CLDN12
claudin 12
chr1_-_23543330 0.420 NM_001102397
NM_001102398
NM_001102399
NM_005826
HNRNPR



heterogeneous nuclear ribonucleoprotein R



chr3_-_137953876 0.419 NM_005862
STAG1
stromal antigen 1
chr7_+_89870647 0.419 NM_001185072
NM_001185073
NM_012129
CLDN12


claudin 12


chr10_+_75343352 0.418 PLAU
plasminogen activator, urokinase
chr1_+_158636987 0.417 NM_020335
VANGL2
vang-like 2 (van gogh, Drosophila)
chr20_+_39090875 0.415 NM_003286
TOP1
topoisomerase (DNA) I
chr3_+_98966253 0.415 NM_032146
NM_177976
ARL6

ADP-ribosylation factor-like 6

chr9_+_22103542 0.412 CDKN2B-AS1
CDKN2B antisense RNA 1 (non-protein coding)
chr1_+_155003939 0.406 PRCC
papillary renal cell carcinoma (translocation-associated)
chr3_+_114192467 0.405 GTPBP8
GTP-binding protein 8 (putative)
chr15_+_61127367 0.402 NM_001018008
TPM1
tropomyosin 1 (alpha)
chr8_-_144313100 0.398 NM_001135655
LY6H
lymphocyte antigen 6 complex, locus H
chr2_-_128000315 0.398 NM_017969
IWS1
IWS1 homolog (S. cerevisiae)
chr19_+_61742111 0.396 NM_020828
ZFP28
zinc finger protein 28 homolog (mouse)
chr12_+_11693909 0.396 ETV6
ets variant 6
chr14_-_50204612 0.395 SAV1
salvador homolog 1 (Drosophila)
chr8_-_91164100 0.394 NM_004929
CALB1
calbindin 1, 28kDa
chr3_-_188946168 0.390 NM_001706
BCL6
B-cell CLL/lymphoma 6
chr3_+_185527734 0.389 EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr16_-_73292188 0.387 NM_001142497
NM_152649
MLKL

mixed lineage kinase domain-like

chr3_-_50624085 0.387 CISH
cytokine inducible SH2-containing protein
chr7_+_55947824 0.387 NM_182633
ZNF713
zinc finger protein 713
chr12_+_132167057 0.386 NM_003440
ZNF140
zinc finger protein 140
chr3_+_142688493 0.386 NM_006506
RASA2
RAS p21 protein activator 2
chr12_+_11693993 0.386 NM_001987
ETV6
ets variant 6
chr1_-_94147616 0.384 GCLM
glutamate-cysteine ligase, modifier subunit
chr8_+_32905027 0.378


chr12_+_63958949 0.376 NM_001193461
MSRB3
methionine sulfoxide reductase B3
chr21_+_25856311 0.372 MIR155HG
MIR155 host gene (non-protein coding)
chr4_-_101658094 0.370 NM_001159694
NM_016242
EMCN

endomucin

chr3_-_193928038 0.367 NM_004113
FGF12
fibroblast growth factor 12
chr3_+_161040439 0.360 SCHIP1
schwannomin interacting protein 1
chr7_-_83116414 0.359 NM_012431
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr9_-_21999270 0.358 NM_004936
NM_078487
CDKN2B

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

chr3_+_137224266 0.357 NM_181897
PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chr19_-_42650178 0.352 NM_152484
ZNF569
zinc finger protein 569
chr14_+_100365390 0.352 MEG3
maternally expressed 3 (non-protein coding)
chr7_-_19778928 0.350 NM_152774
TMEM196
transmembrane protein 196
chr15_-_41185460 0.350 NM_174916
UBR1
ubiquitin protein ligase E3 component n-recognin 1
chr8_-_79880095 0.349 NM_000880
IL7
interleukin 7
chr6_-_26393705 0.348 NM_003543
HIST1H4H
histone cluster 1, H4h
chr12_-_11075272 0.347 NM_176885
TAS2R31
taste receptor, type 2, member 31
chr8_-_144313053 0.347 LY6H
lymphocyte antigen 6 complex, locus H
chr1_+_155003897 0.347 NM_005973
PRCC
papillary renal cell carcinoma (translocation-associated)
chr19_+_61798434 0.345 NM_021216
ZNF71
zinc finger protein 71
chr19_+_2427122 0.343 NM_015675
GADD45B
growth arrest and DNA-damage-inducible, beta
chr11_-_102331643 0.343 NM_002427
MMP13
matrix metallopeptidase 13 (collagenase 3)
chr1_-_143706300 0.341 NM_001002812
NM_014644
NM_001002810
NM_001198834
NM_001195261
PDE4DIP




phosphodiesterase 4D interacting protein




chr19_+_49180171 0.340 NM_003445
NM_198089
ZNF155

zinc finger protein 155

chr10_-_121346464 0.340 TIAL1
TIA1 cytotoxic granule-associated RNA binding protein-like 1
chr10_+_86121526 0.338 FAM190B
family with sequence similarity 190, member B
chr15_+_65145248 0.335 NM_005902
SMAD3
SMAD family member 3
chr19_-_49131250 0.332 NM_003425
ZNF45
zinc finger protein 45
chr8_+_103889733 0.329 FLJ45248
FLJ45248 protein
chr12_+_63958689 0.329 NM_001031679
NM_001193460
NM_198080
MSRB3


methionine sulfoxide reductase B3


chr22_-_29866339 0.328 NM_015715
PLA2G3
phospholipase A2, group III
chr9_-_34618010 0.328 NM_001017363
ARID3C
AT rich interactive domain 3C (BRIGHT-like)
chr11_-_133220578 0.327 NM_174927
SPATA19
spermatogenesis associated 19
chr11_+_32069183 0.327 RCN1
reticulocalbin 1, EF-hand calcium binding domain
chr19_+_17377502 0.322 LOC100507535
hypothetical LOC100507535
chr10_+_74540215 0.322 NM_015901
NUDT13
nudix (nucleoside diphosphate linked moiety X)-type motif 13
chr1_-_94147537 0.322 GCLM
glutamate-cysteine ligase, modifier subunit
chr11_-_83706027 0.319 DLG2
discs, large homolog 2 (Drosophila)
chr3_+_186483408 0.318 LOC100505749
MAP3K13
hypothetical LOC100505749
mitogen-activated protein kinase kinase kinase 13
chr1_+_173111306 0.314 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr22_-_35011703 0.314 MYH9
myosin, heavy chain 9, non-muscle
chr3_+_161189322 0.314 NM_000882
IL12A
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
chr2_-_11727705 0.313 NM_012344
NTSR2
neurotensin receptor 2
chr16_-_3049336 0.313


chr9_-_21375258 0.312 NM_000605
IFNA2
interferon, alpha 2
chr12_+_115455579 0.309 NCRNA00173
non-protein coding RNA 173
chr17_+_6484945 0.309 NM_032731
TXNDC17
thioredoxin domain containing 17
chr17_+_11864841 0.308 NM_003010
MAP2K4
mitogen-activated protein kinase kinase 4
chr10_-_121345968 0.308 TIAL1
TIA1 cytotoxic granule-associated RNA binding protein-like 1
chr19_+_49290319 0.307 NM_013398
ZNF224
zinc finger protein 224
chr22_-_30018329 0.305 NM_001135911
NM_052880
PIK3IP1

phosphoinositide-3-kinase interacting protein 1

chr10_+_88506320 0.305 NM_004329
BMPR1A
bone morphogenetic protein receptor, type IA
chr19_+_49023283 0.304 NM_181845
ZNF283
zinc finger protein 283
chr1_+_63861474 0.304 NM_001172818
PGM1
phosphoglucomutase 1
chr13_-_25687062 0.302 RNF6
ring finger protein (C3H2C3 type) 6
chr3_+_112273352 0.302 PVRL3
poliovirus receptor-related 3
chr12_+_7038240 0.302 NM_001734
NM_201442
C1S

complement component 1, s subcomponent

chr11_-_104399104 0.302 NM_001136109
NM_001136110
NM_001136112
NM_004347
CASP5



caspase 5, apoptosis-related cysteine peptidase



chr15_+_68971835 0.301 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr11_+_33235743 0.301 NM_001048200
NM_005734
HIPK3

homeodomain interacting protein kinase 3

chr19_+_49221333 0.301 NM_001129996
NM_013360
ZNF284
ZNF222

zinc finger protein 284
zinc finger protein 222

chr10_-_121346517 0.299 NM_001033925
NM_003252
TIAL1

TIA1 cytotoxic granule-associated RNA binding protein-like 1

chr5_-_138238877 0.299 LRRTM2
leucine rich repeat transmembrane neuronal 2
chr8_-_130868315 0.298 NM_031415
GSDMC
gasdermin C
chr3_-_48015264 0.298 MAP4
microtubule-associated protein 4
chr18_+_59733724 0.298 NM_005024
SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr11_-_7804094 0.297 NM_153445
OR5P3
olfactory receptor, family 5, subfamily P, member 3
chr17_-_6484970 0.296 NM_014804
KIAA0753
KIAA0753
chr14_+_20568184 0.296 NM_173846
TPPP2
tubulin polymerization-promoting protein family member 2
chr9_+_71625550 0.294 NM_001010940
C9orf135
chromosome 9 open reading frame 135
chr17_+_7753428 0.293 CHD3
chromodomain helicase DNA binding protein 3
chr11_+_32068990 0.293 NM_002901
RCN1
reticulocalbin 1, EF-hand calcium binding domain
chr12_+_887272 0.290 WNK1
WNK lysine deficient protein kinase 1
chr13_+_36146048 0.290 NM_203451
C13orf36
chromosome 13 open reading frame 36
chr4_-_140420789 0.288 NM_032623
C4orf49
chromosome 4 open reading frame 49
chr1_+_22011344 0.288 NM_001013693
LDLRAD2
low density lipoprotein receptor class A domain containing 2
chr3_+_62279707 0.287 C3orf14
chromosome 3 open reading frame 14
chr16_+_52295375 0.287 NM_001080432
FTO
fat mass and obesity associated
chr15_-_40173949 0.287 NM_178034
PLA2G4D
phospholipase A2, group IVD (cytosolic)
chr14_-_50204771 0.286 NM_021818
SAV1
salvador homolog 1 (Drosophila)
chr15_+_92700167 0.286 NM_001159644
MCTP2
multiple C2 domains, transmembrane 2
chr1_-_143706196 0.286 PDE4DIP
phosphodiesterase 4D interacting protein
chr19_+_49268106 0.286 NM_001037813
ZNF284
zinc finger protein 284
chr3_+_150028130 0.285 NM_001871
CPB1
carboxypeptidase B1 (tissue)
chr19_+_49309350 0.284 NM_013362
ZNF225
zinc finger protein 225
chr2_+_228064531 0.284 AGFG1
ArfGAP with FG repeats 1
chr17_-_37275142 0.284 NM_018143
KLHL11
kelch-like 11 (Drosophila)
chr14_-_79748273 0.284 NM_000793
NM_013989
DIO2

deiodinase, iodothyronine, type II

chr11_-_123130435 0.283 NM_001005188
OR6X1
olfactory receptor, family 6, subfamily X, member 1
chr3_+_161040343 0.283 NM_001197109
SCHIP1
schwannomin interacting protein 1
chr14_+_64450892 0.283 NM_145165
CHURC1
churchill domain containing 1
chr12_+_12857516 0.282 NM_016355
NM_201224
DDX47

DEAD (Asp-Glu-Ala-Asp) box polypeptide 47

chr11_+_113672378 0.282 NNMT
nicotinamide N-methyltransferase
chr11_-_26700121 0.282 NM_178498
SLC5A12
solute carrier family 5 (sodium/glucose cotransporter), member 12
chr15_-_48198697 0.281 NM_024837
ATP8B4
ATPase, class I, type 8B, member 4
chr15_+_42808611 0.281 TRIM69
tripartite motif containing 69
chr16_+_31390567 0.281 NM_001042454
NM_001164719
TGFB1I1

transforming growth factor beta 1 induced transcript 1

chr11_-_125278296 0.281 NM_031307
PUS3
pseudouridylate synthase 3
chr1_-_143706265 0.280 PDE4DIP
phosphodiesterase 4D interacting protein
chr12_+_13088412 0.280 KIAA1467
KIAA1467
chr18_+_30427279 0.280 NM_001128175
NM_001198938
NM_001198939
NM_001198940
DTNA



dystrobrevin, alpha



chr6_-_137155414 0.279 MAP3K5
mitogen-activated protein kinase kinase kinase 5
chr12_+_8958397 0.279 NM_004426
PHC1
polyhomeotic homolog 1 (Drosophila)
chr17_+_6288457 0.279 NM_001195228
NM_019013
FAM64A

family with sequence similarity 64, member A

chr11_+_113672407 0.278 NNMT
nicotinamide N-methyltransferase
chr4_+_128870968 0.277 NM_031291
SLC25A31
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31
chr11_-_93223315 0.277 NM_001144871
C11orf90
chromosome 11 open reading frame 90
chr18_-_55091596 0.277 NM_013435
RAX
retina and anterior neural fold homeobox
chr3_+_123882355 0.277 NM_017554
PARP14
poly (ADP-ribose) polymerase family, member 14
chr1_+_113734997 0.277 NM_001142782
NM_152900
MAGI3

membrane associated guanylate kinase, WW and PDZ domain containing 3

chr12_+_13088551 0.276 NM_020853
KIAA1467
KIAA1467
chr14_+_64450931 0.276 CHURC1-FNTB
CHURC1
CHURC1-FNTB read-through transcript
churchill domain containing 1
chr15_-_100280784 0.275 NM_001004195
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr17_-_1306160 0.271 NM_005206
NM_016823
CRK

v-crk sarcoma virus CT10 oncogene homolog (avian)

chr2_-_166940710 0.271 NM_002977
SCN9A
sodium channel, voltage-gated, type IX, alpha subunit
chr5_-_147191334 0.270 SPINK1
serine peptidase inhibitor, Kazal type 1

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.12 6.81e-03 GO:0005634 nucleus

Nothing significant found in function category.