Motif ID: TFAP2B.p2

Z-value: 1.690


Transcription factors associated with TFAP2B.p2:

Gene SymbolEntrez IDGene Name
TFAP2B 7021 transcription factor AP-2 beta (activating enhancer binding protein 2 beta)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFAP2Bchr6_+_508943970.039.0e-01Click!


Activity profile for motif TFAP2B.p2.

activity profile for motif TFAP2B.p2


Sorted Z-values histogram for motif TFAP2B.p2

Sorted Z-values for motif TFAP2B.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2B.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_41622267 2.793 FOXP4
forkhead box P4
chr2_-_160972606 2.711 RBMS1
RNA binding motif, single stranded interacting protein 1
chr6_+_167970334 2.398 NM_001040000
 MLLT4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
chr20_+_56899904 2.365 GNAS
GNAS complex locus
chr20_+_56899867 2.347 GNAS
GNAS complex locus
chr6_+_157140954 2.324 ARID1B
AT rich interactive domain 1B (SWI1-like)
chr17_+_75849221 2.204 NM_020914
NM_020954
 RNF213

ring finger protein 213

chr10_+_104394185 2.185 NM_030912
 TRIM8
tripartite motif containing 8
chr20_+_56899643 2.155 NM_001077489
NM_000516
NM_080426
 GNAS


GNAS complex locus


chr6_+_41622111 2.136 NM_001012426
NM_001012427
NM_138457
 FOXP4


forkhead box P4


chr16_+_49139694 2.001 NM_033119
 NKD1
naked cuticle homolog 1 (Drosophila)
chr2_+_96845704 1.972 NM_017623
NM_199078
 CNNM3

cyclin M3

chr6_+_157140733 1.848 NM_017519
NM_020732
 ARID1B

AT rich interactive domain 1B (SWI1-like)

chr9_+_95378492 1.823 NM_005392
 PHF2
PHD finger protein 2
chr22_+_48740432 1.801 PIM3
pim-3 oncogene
chr2_+_236067687 1.708 AGAP1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
chr16_+_87047418 1.688 NM_153813
 ZFPM1
zinc finger protein, multitype 1
chr13_+_112392355 1.677 NM_015205
NM_032189
 ATP11A

ATPase, class VI, type 11A

chr6_+_157140895 1.662


chr8_+_81560971 1.633 NM_001105539
NM_023929
 ZBTB10

zinc finger and BTB domain containing 10


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 169 entries
enrichment   p-value GO term description
2.36 1.74e-02 GO:0010717 regulation of epithelial to mesenchymal transition
2.23 4.56e-02 GO:0090263 positive regulation of canonical Wnt receptor signaling pathway
2.10 1.93e-02 GO:0030177 positive regulation of Wnt receptor signaling pathway
1.92 1.91e-02 GO:0001838 embryonic epithelial tube formation
1.89 3.31e-02 GO:0072175 epithelial tube formation
1.81 9.78e-03 GO:0021915 neural tube development
1.76 2.15e-02 GO:0060828 regulation of canonical Wnt receptor signaling pathway
1.75 1.60e-04 GO:0030111 regulation of Wnt receptor signaling pathway
1.59 6.34e-03 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
1.57 3.47e-02 GO:0051099 positive regulation of binding
1.56 7.68e-09 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.51 1.58e-06 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.51 1.65e-02 GO:0032582 negative regulation of gene-specific transcription
1.50 1.05e-09 GO:0045892 negative regulation of transcription, DNA-dependent
1.50 1.45e-03 GO:0090046 regulation of transcription regulator activity
1.50 1.94e-03 GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
1.48 3.86e-09 GO:0051253 negative regulation of RNA metabolic process
1.48 1.52e-06 GO:0009968 negative regulation of signal transduction
1.47 1.25e-06 GO:0010648 negative regulation of cell communication
1.47 2.15e-04 GO:0007411 axon guidance

Gene overrepresentation in compartment category:

Showing 1 to 20 of 41 entries
enrichment   p-value GO term description
1.87 3.76e-03 GO:0031256 leading edge membrane
1.83 3.62e-02 GO:0031901 early endosome membrane
1.77 3.75e-07 GO:0005912 adherens junction
1.70 2.40e-06 GO:0070161 anchoring junction
1.68 4.58e-03 GO:0005925 focal adhesion
1.66 5.02e-03 GO:0005924 cell-substrate adherens junction
1.63 9.03e-03 GO:0030055 cell-substrate junction
1.49 6.36e-03 GO:0031252 cell leading edge
1.45 1.25e-02 GO:0005911 cell-cell junction
1.44 2.38e-03 GO:0005667 transcription factor complex
1.34 9.22e-07 GO:0044451 nucleoplasm part
1.32 3.29e-02 GO:0048471 perinuclear region of cytoplasm
1.29 1.51e-09 GO:0005654 nucleoplasm
1.28 1.47e-15 GO:0044428 nuclear part
1.27 3.40e-12 GO:0031981 nuclear lumen
1.26 1.63e-02 GO:0044431 Golgi apparatus part
1.25 6.91e-03 GO:0015630 microtubule cytoskeleton
1.24 1.23e-10 GO:0005829 cytosol
1.23 6.42e-11 GO:0070013 intracellular organelle lumen
1.22 6.80e-10 GO:0043233 organelle lumen

Gene overrepresentation in function category:

Showing 1 to 20 of 40 entries
enrichment   p-value GO term description
1.89 2.24e-02 GO:0008301 DNA bending activity
1.76 6.04e-03 GO:0003705 sequence-specific enhancer binding RNA polymerase II transcription factor activity
1.69 1.39e-02 GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
1.59 3.79e-08 GO:0008134 transcription factor binding
1.57 1.48e-04 GO:0010843 promoter binding
1.56 1.20e-07 GO:0016564 transcription repressor activity
1.54 3.78e-04 GO:0000975 regulatory region DNA binding
1.54 3.78e-04 GO:0001067 regulatory region nucleic acid binding
1.54 3.78e-04 GO:0044212 transcription regulatory region DNA binding
1.54 6.40e-03 GO:0004721 phosphoprotein phosphatase activity
1.47 3.51e-05 GO:0016563 transcription activator activity
1.46 3.06e-02 GO:0043566 structure-specific DNA binding
1.45 6.53e-07 GO:0019904 protein domain specific binding
1.40 4.00e-02 GO:0016791 phosphatase activity
1.32 9.04e-03 GO:0004674 protein serine/threonine kinase activity
1.30 3.64e-07 GO:0030528 transcription regulator activity
1.30 4.98e-05 GO:0016301 kinase activity
1.28 3.27e-04 GO:0019899 enzyme binding
1.28 4.55e-04 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.28 1.15e-03 GO:0043565 sequence-specific DNA binding