Motif ID: TFAP2B.p2

Z-value: 1.690


Transcription factors associated with TFAP2B.p2:

Gene SymbolEntrez IDGene Name
TFAP2B 7021 transcription factor AP-2 beta (activating enhancer binding protein 2 beta)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFAP2Bchr6_+_508943970.039.0e-01Click!


Activity profile for motif TFAP2B.p2.

activity profile for motif TFAP2B.p2


Sorted Z-values histogram for motif TFAP2B.p2

Sorted Z-values for motif TFAP2B.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2B.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_41622267 2.793 FOXP4
forkhead box P4
chr2_-_160972606 2.711 RBMS1
RNA binding motif, single stranded interacting protein 1
chr6_+_167970334 2.398 NM_001040000
MLLT4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
chr20_+_56899904 2.365 GNAS
GNAS complex locus
chr20_+_56899867 2.347 GNAS
GNAS complex locus
chr6_+_157140954 2.324 ARID1B
AT rich interactive domain 1B (SWI1-like)
chr17_+_75849221 2.204 NM_020914
NM_020954
RNF213

ring finger protein 213

chr10_+_104394185 2.185 NM_030912
TRIM8
tripartite motif containing 8
chr20_+_56899643 2.155 NM_001077489
NM_000516
NM_080426
GNAS


GNAS complex locus


chr6_+_41622111 2.136 NM_001012426
NM_001012427
NM_138457
FOXP4


forkhead box P4


chr16_+_49139694 2.001 NM_033119
NKD1
naked cuticle homolog 1 (Drosophila)
chr2_+_96845704 1.972 NM_017623
NM_199078
CNNM3

cyclin M3

chr6_+_157140733 1.848 NM_017519
NM_020732
ARID1B

AT rich interactive domain 1B (SWI1-like)

chr9_+_95378492 1.823 NM_005392
PHF2
PHD finger protein 2
chr22_+_48740432 1.801 PIM3
pim-3 oncogene
chr2_+_236067687 1.708 AGAP1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
chr16_+_87047418 1.688 NM_153813
ZFPM1
zinc finger protein, multitype 1
chr13_+_112392355 1.677 NM_015205
NM_032189
ATP11A

ATPase, class VI, type 11A

chr6_+_157140895 1.662


chr8_+_81560971 1.633 NM_001105539
NM_023929
ZBTB10

zinc finger and BTB domain containing 10

chr22_+_48633532 1.577 ZBED4
zinc finger, BED-type containing 4
chr17_+_75366524 1.518 NM_005189
NM_032647
CBX2

chromobox homolog 2

chr2_+_101680594 1.506 NM_004834
NM_145686
NM_145687
MAP4K4


mitogen-activated protein kinase kinase kinase kinase 4


chr16_+_87047159 1.494 ZFPM1
zinc finger protein, multitype 1
chr22_+_20101661 1.477 NM_015094
HIC2
hypermethylated in cancer 2
chr22_+_48633484 1.464 NM_014838
ZBED4
zinc finger, BED-type containing 4
chr20_+_60130866 1.462 NM_144703
LSM14B
LSM14B, SCD6 homolog B (S. cerevisiae)
chr17_+_77582774 1.440 NM_005052
RAC3
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
chr8_+_17398940 1.336 NM_001008539
SLC7A2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
chrX_+_152606945 1.324 NM_001142805
NM_005629
SLC6A8

solute carrier family 6 (neurotransmitter transporter, creatine), member 8

chr2_+_236067424 1.322 NM_001037131
NM_014914
AGAP1

ArfGAP with GTPase domain, ankyrin repeat and PH domain 1

chr2_+_241156776 1.319 NM_018226
RNPEPL1
arginyl aminopeptidase (aminopeptidase B)-like 1
chr20_+_60130963 1.316 LSM14B
LSM14B, SCD6 homolog B (S. cerevisiae)
chr20_-_30636535 1.291 LOC284804
hypothetical protein LOC284804
chr17_+_17525571 1.251


chr13_-_112392051 1.249 LOC440149
hypothetical LOC440149
chr19_+_540849 1.223 NM_001194
HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr18_+_58341637 1.216 NM_017742
ZCCHC2
zinc finger, CCHC domain containing 2
chr9_+_137511448 1.216 NM_014811
KIAA0649
KIAA0649
chr20_+_226200 1.202 NM_033089
ZCCHC3
zinc finger, CCHC domain containing 3
chr20_-_47327998 1.201 NM_021035
ZNFX1
zinc finger, NFX1-type containing 1
chr20_+_56900116 1.198 NM_001077488
GNAS
GNAS complex locus
chr20_-_60151753 1.183 PSMA7
proteasome (prosome, macropain) subunit, alpha type, 7
chr17_+_78630793 1.166 NM_001004431
METRNL
meteorin, glial cell differentiation regulator-like
chr6_+_36754433 1.154 NM_000389
CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr22_+_48740143 1.153 NM_001001852
PIM3
pim-3 oncogene
chr16_+_88517187 1.152 NM_006086
TUBB3
tubulin, beta 3
chr20_-_60151802 1.139 PSMA7
proteasome (prosome, macropain) subunit, alpha type, 7
chr20_+_48241334 1.129 CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chr20_-_60151835 1.104 NM_002792
PSMA7
proteasome (prosome, macropain) subunit, alpha type, 7
chr1_-_8406288 1.101 NM_001042682
RERE
arginine-glutamic acid dipeptide (RE) repeats
chr17_+_78070853 1.087 NM_004514
FOXK2
forkhead box K2
chr11_+_67836575 1.070 NM_002335
LRP5
low density lipoprotein receptor-related protein 5
chr21_+_45649429 1.049 NM_130445
COL18A1
collagen, type XVIII, alpha 1
chr7_+_137795719 1.032 TRIM24
tripartite motif containing 24
chr20_-_61933012 1.022 ZBTB46
zinc finger and BTB domain containing 46
chr2_+_231610438 1.020 NM_001144994
C2orf72
chromosome 2 open reading frame 72
chr14_+_104852225 1.017 PACS2
phosphofurin acidic cluster sorting protein 2
chr21_+_45649719 1.016


chr9_+_137119339 1.003 OLFM1
olfactomedin 1
chr9_+_137119334 0.992 OLFM1
olfactomedin 1
chr6_+_43846155 0.986 VEGFA
vascular endothelial growth factor A
chr20_+_48240867 0.983 CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chr5_+_179180517 0.970 SQSTM1
sequestosome 1
chr20_+_4077409 0.960 NM_175839
NM_175840
NM_175841
NM_175842
SMOX



spermine oxidase



chr7_+_150442652 0.953 AGAP3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
chr17_+_17525497 0.950 NM_030665
RAI1
retinoic acid induced 1
chr6_+_160689355 0.942 NM_021977
SLC22A3
solute carrier family 22 (extraneuronal monoamine transporter), member 3
chr5_+_179180695 0.939 SQSTM1
sequestosome 1
chr22_+_21852911 0.939 BCR
breakpoint cluster region
chr14_+_105063975 0.935 NM_025268
TMEM121
transmembrane protein 121
chr5_+_139008667 0.929 CXXC5
CXXC finger protein 5
chr6_+_37245860 0.925 NM_002648
PIM1
pim-1 oncogene
chr3_+_32834513 0.924 NM_001039111
TRIM71
tripartite motif containing 71
chr18_+_8599407 0.916 NM_001025300
RAB12
RAB12, member RAS oncogene family
chr20_+_4077466 0.916 SMOX
spermine oxidase
chr17_+_63252704 0.911 BPTF
bromodomain PHD finger transcription factor
chr17_+_72880967 0.908 SEPT9
septin 9
chr16_+_2138688 0.900 RAB26
RAB26, member RAS oncogene family
chr20_+_35407872 0.900 NM_198291
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr20_+_48240772 0.889 NM_005194
CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chr1_+_9571518 0.884 NM_001010866
NM_001130924
TMEM201

transmembrane protein 201

chr7_+_882766 0.881 GET4
golgi to ER traffic protein 4 homolog (S. cerevisiae)
chr17_+_72376022 0.875 NM_144677
MGAT5B
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B
chr6_+_157141565 0.874 ARID1B
AT rich interactive domain 1B (SWI1-like)
chr10_+_82204051 0.873 TSPAN14
tetraspanin 14
chr14_-_22596522 0.871 NM_022478
NM_144985
CDH24

cadherin 24, type 2

chr10_+_82203872 0.867 NM_001128309
NM_030927
TSPAN14

tetraspanin 14

chr14_+_55116549 0.861 NM_001079521
NM_001079522
NM_004986
NM_182926
KTN1



kinectin 1 (kinesin receptor)



chr7_+_882704 0.859 NM_015949
GET4
golgi to ER traffic protein 4 homolog (S. cerevisiae)
chr10_+_82204054 0.854 TSPAN14
tetraspanin 14
chr6_+_36754467 0.851 CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr14_+_99774854 0.850 NM_003403
YY1
YY1 transcription factor
chr19_+_7566698 0.848 NM_001080429
NM_020902
KIAA1543

KIAA1543

chr2_+_8739563 0.847 NM_002166
ID2
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
chr16_-_87535106 0.841 NM_175931
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr16_-_88410523 0.841 NM_000135
NM_001018112
FANCA

Fanconi anemia, complementation group A

chr9_+_136358145 0.839 RXRA
retinoid X receptor, alpha
chr11_+_566482 0.835 NM_020901
PHRF1
PHD and ring finger domains 1
chr3_+_23961739 0.833 NM_005126
NR1D2
nuclear receptor subfamily 1, group D, member 2
chr16_-_11798507 0.827 ZC3H7A
zinc finger CCCH-type containing 7A
chr6_+_43151922 0.825 NM_002821
NM_152880
NM_152881
NM_152882
PTK7



PTK7 protein tyrosine kinase 7



chr1_+_24944554 0.822 CLIC4
chloride intracellular channel 4
chr6_+_158164294 0.822 SNX9
sorting nexin 9
chr9_+_114288899 0.821 NM_133465
KIAA1958
KIAA1958
chr16_+_66120205 0.816 NM_024519
NM_001193522
FAM65A

family with sequence similarity 65, member A

chr9_+_136358134 0.814 NM_002957
RXRA
retinoid X receptor, alpha
chr4_+_1842833 0.812 NM_001042424
WHSC1
Wolf-Hirschhorn syndrome candidate 1
chr20_-_61028319 0.807 NM_001193369
NM_001193370
NM_080796
DIDO1


death inducer-obliterator 1


chr17_+_59053518 0.805 NM_002401
NM_203351
MAP3K3

mitogen-activated protein kinase kinase kinase 3

chr2_+_242289983 0.805 NM_032329
ING5
inhibitor of growth family, member 5
chr9_+_114289178 0.804 KIAA1958
KIAA1958
chr20_+_2621193 0.802 NM_001110514
EBF4
early B-cell factor 4
chr3_+_43303005 0.799 NM_001100594
NM_017719
SNRK

SNF related kinase

chr12_+_121885930 0.798 NM_003959
HIP1R
huntingtin interacting protein 1 related
chr22_+_36531178 0.797 H1F0
H1 histone family, member 0
chr2_+_239000306 0.794 NM_001040445
ASB1
ankyrin repeat and SOCS box containing 1
chr10_+_99176028 0.789 PGAM1
phosphoglycerate mutase 1 (brain)
chr20_+_56701224 0.786 NM_024663
NPEPL1
aminopeptidase-like 1
chr4_+_1842947 0.785 WHSC1
Wolf-Hirschhorn syndrome candidate 1
chr16_+_3010311 0.783 NM_016639
TNFRSF12A
tumor necrosis factor receptor superfamily, member 12A
chr8_+_61753912 0.782 CHD7
chromodomain helicase DNA binding protein 7
chr22_+_36531059 0.775 NM_005318
H1F0
H1 histone family, member 0
chr3_+_192529567 0.772 NM_174908
NM_178335
CCDC50

coiled-coil domain containing 50

chr5_+_179180509 0.767 SQSTM1
sequestosome 1
chr7_+_6111115 0.767 USP42
ubiquitin specific peptidase 42
chr10_+_82204046 0.765 TSPAN14
tetraspanin 14
chr17_+_59053515 0.764 MAP3K3
mitogen-activated protein kinase kinase kinase 3
chr20_-_46877811 0.758 NM_020820
PREX1
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
chr5_+_179180447 0.757 NM_003900
SQSTM1
sequestosome 1
chr6_+_1556543 0.756 FOXC1
forkhead box C1
chr2_+_9264360 0.756 ASAP2
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
chr2_+_239000395 0.754 ASB1
ankyrin repeat and SOCS box containing 1
chr2_+_233927892 0.753 DGKD
diacylglycerol kinase, delta 130kDa
chr7_+_7188667 0.752 NM_020156
C1GALT1
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
chr19_+_1200882 0.746 MIDN
midnolin
chr16_+_83291107 0.746 USP10
ubiquitin specific peptidase 10
chr20_+_34635362 0.743 NM_021809
TGIF2
TGFB-induced factor homeobox 2
chr19_+_3045528 0.741 GNA11
guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
chr9_+_128416542 0.740 NM_001174146
NM_001174147
NM_002316
LMX1B


LIM homeobox transcription factor 1, beta


chr2_+_173129119 0.740 PDK1
pyruvate dehydrogenase kinase, isozyme 1
chr20_+_60151868 0.738 NM_198935
SS18L1
synovial sarcoma translocation gene on chromosome 18-like 1
chr20_-_61600834 0.733 NM_001958
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr6_+_2711227 0.731 WRNIP1
Werner helicase interacting protein 1
chr19_+_482688 0.725 NM_004359
CDC34
cell division cycle 34 homolog (S. cerevisiae)
chr17_+_69939806 0.722 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr1_+_945331 0.722 NM_198576
AGRN
agrin
chr16_+_83291055 0.721 NM_005153
USP10
ubiquitin specific peptidase 10
chr10_-_99175685 0.720


chr17_+_14145051 0.718 NM_006041
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr10_+_99176032 0.717 PGAM1
phosphoglycerate mutase 1 (brain)
chr3_+_38470782 0.717 NM_001106
ACVR2B
activin A receptor, type IIB
chr16_+_83291097 0.717 USP10
ubiquitin specific peptidase 10
chr10_+_99176030 0.714 PGAM1
phosphoglycerate mutase 1 (brain)
chr10_+_99176002 0.712 PGAM1
phosphoglycerate mutase 1 (brain)
chr13_+_97593411 0.711 NM_001001715
NM_005766
FARP1

FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)

chr16_+_1299361 0.708 NM_194260
UBE2I
ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)
chr18_+_18969724 0.708 NM_001100619
CABLES1
Cdk5 and Abl enzyme substrate 1
chr1_+_51474583 0.706 RNF11
ring finger protein 11
chr1_+_2149993 0.706 NM_003036
SKI
v-ski sarcoma viral oncogene homolog (avian)
chr10_+_80498782 0.704 NM_020338
ZMIZ1
zinc finger, MIZ-type containing 1
chr13_+_97593469 0.703 FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr10_+_99175949 0.701 PGAM1
phosphoglycerate mutase 1 (brain)
chr20_-_61108831 0.701 NM_080606
BHLHE23
basic helix-loop-helix family, member e23
chr14_+_35072998 0.699 NM_032594
INSM2
insulinoma-associated 2
chr15_+_97009194 0.699 IGF1R
insulin-like growth factor 1 receptor
chr10_+_80672842 0.698 ZMIZ1
zinc finger, MIZ-type containing 1
chr6_+_158164269 0.696 NM_016224
SNX9
sorting nexin 9
chr2_+_233927880 0.693 NM_152879
DGKD
diacylglycerol kinase, delta 130kDa
chr7_+_2638108 0.690 NM_025250
TTYH3
tweety homolog 3 (Drosophila)
chr1_-_33669190 0.690 PHC2
polyhomeotic homolog 2 (Drosophila)
chr6_+_160068135 0.689 NM_004906
NM_152858
WTAP

Wilms tumor 1 associated protein

chr6_+_43846372 0.687 VEGFA
vascular endothelial growth factor A
chr20_+_5934964 0.686 CRLS1
cardiolipin synthase 1
chr5_+_139008091 0.686 CXXC5
CXXC finger protein 5
chr2_+_236068029 0.685 AGAP1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
chr20_+_5934560 0.683 NM_019095
CRLS1
cardiolipin synthase 1
chr2_+_100802923 0.683 NM_002518
NPAS2
neuronal PAS domain protein 2
chr5_+_139008139 0.682 CXXC5
CXXC finger protein 5
chr16_+_1143738 0.681 CACNA1H
calcium channel, voltage-dependent, T type, alpha 1H subunit
chr10_+_99175967 0.680 PGAM1
phosphoglycerate mutase 1 (brain)
chr16_+_29725665 0.679


chr10_+_99176007 0.678 NM_002629
PGAM1
phosphoglycerate mutase 1 (brain)
chr6_+_64403631 0.677 PHF3
PHD finger protein 3
chr17_+_52517529 0.676 NM_003488
AKAP1
A kinase (PRKA) anchor protein 1
chr2_+_170298487 0.675


chr20_+_24398269 0.674 TMEM90B
transmembrane protein 90B
chr7_+_150414704 0.671 NM_001042535
NM_031946
AGAP3

ArfGAP with GTPase domain, ankyrin repeat and PH domain 3

chr20_+_254205 0.670 NM_006943
SOX12
SRY (sex determining region Y)-box 12
chr20_+_5934761 0.669 CRLS1
cardiolipin synthase 1
chr16_+_73590470 0.668 ZNRF1
zinc and ring finger 1
chr5_+_56147109 0.668 MAP3K1
mitogen-activated protein kinase kinase kinase 1
chr17_+_52518098 0.666 AKAP1
A kinase (PRKA) anchor protein 1
chr12_+_67919583 0.665 NM_007007
CPSF6
cleavage and polyadenylation specific factor 6, 68kDa
chr2_+_173129040 0.664 PDK1
pyruvate dehydrogenase kinase, isozyme 1
chr1_+_945399 0.663


chr16_+_73590419 0.661 ZNRF1
zinc and ring finger 1
chr5_+_139008209 0.659 NM_016463
CXXC5
CXXC finger protein 5
chr19_+_1358531 0.657 NM_018959
NM_170711
DAZAP1

DAZ associated protein 1

chr10_+_99175933 0.656 PGAM1
phosphoglycerate mutase 1 (brain)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.10 8.71e-25 GO:0009987 cellular process
1.30 1.42e-16 GO:0048523 negative regulation of cellular process
1.15 4.91e-16 GO:0044237 cellular metabolic process
1.28 8.72e-16 GO:0048519 negative regulation of biological process
1.13 1.01e-14 GO:0050794 regulation of cellular process
1.18 1.58e-14 GO:0044260 cellular macromolecule metabolic process
1.21 2.20e-14 GO:0016043 cellular component organization
1.21 2.53e-14 GO:0071840 cellular component organization or biogenesis
1.24 1.65e-13 GO:0071841 cellular component organization or biogenesis at cellular level
1.24 2.11e-13 GO:0071842 cellular component organization at cellular level
1.12 1.32e-12 GO:0050789 regulation of biological process
1.19 1.39e-12 GO:0031323 regulation of cellular metabolic process
1.32 2.38e-12 GO:0007399 nervous system development
1.19 1.42e-11 GO:0080090 regulation of primary metabolic process
1.11 1.47e-11 GO:0065007 biological regulation
1.19 1.79e-11 GO:0060255 regulation of macromolecule metabolic process
1.11 3.54e-11 GO:0008152 metabolic process
1.38 5.20e-11 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.17 6.81e-11 GO:0019222 regulation of metabolic process
1.31 1.25e-10 GO:0009966 regulation of signal transduction
1.22 4.13e-10 GO:0010468 regulation of gene expression
1.17 4.20e-10 GO:0032502 developmental process
1.14 5.21e-10 GO:0043170 macromolecule metabolic process
1.44 7.27e-10 GO:0009890 negative regulation of biosynthetic process
1.22 9.21e-10 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.50 1.05e-09 GO:0045892 negative regulation of transcription, DNA-dependent
1.27 1.27e-09 GO:0023051 regulation of signaling
1.12 1.34e-09 GO:0044238 primary metabolic process
1.20 2.24e-09 GO:0031326 regulation of cellular biosynthetic process
1.43 2.52e-09 GO:0031327 negative regulation of cellular biosynthetic process
1.21 2.88e-09 GO:0048522 positive regulation of cellular process
1.44 3.27e-09 GO:0010558 negative regulation of macromolecule biosynthetic process
1.45 3.28e-09 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.48 3.86e-09 GO:0051253 negative regulation of RNA metabolic process
1.37 5.18e-09 GO:0031324 negative regulation of cellular metabolic process
1.17 6.33e-09 GO:0007275 multicellular organismal development
1.45 6.42e-09 GO:0010629 negative regulation of gene expression
1.56 7.68e-09 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.22 7.72e-09 GO:0051252 regulation of RNA metabolic process
1.20 9.30e-09 GO:0009889 regulation of biosynthetic process
1.21 1.07e-08 GO:0010556 regulation of macromolecule biosynthetic process
1.34 1.13e-08 GO:0009892 negative regulation of metabolic process
1.27 3.25e-08 GO:0009653 anatomical structure morphogenesis
1.35 4.28e-08 GO:0022008 neurogenesis
1.36 5.82e-08 GO:0048699 generation of neurons
1.19 7.10e-08 GO:0048518 positive regulation of biological process
1.25 8.15e-08 GO:0006996 organelle organization
1.42 1.15e-07 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.22 1.15e-07 GO:0048869 cellular developmental process
1.17 1.50e-07 GO:0006807 nitrogen compound metabolic process
1.34 1.59e-07 GO:0010605 negative regulation of macromolecule metabolic process
1.42 1.70e-07 GO:0051172 negative regulation of nitrogen compound metabolic process
1.42 1.85e-07 GO:0000902 cell morphogenesis
1.18 2.01e-07 GO:0051171 regulation of nitrogen compound metabolic process
1.19 2.02e-07 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.30 2.06e-07 GO:0010604 positive regulation of macromolecule metabolic process
1.21 2.89e-07 GO:0006355 regulation of transcription, DNA-dependent
1.16 6.99e-07 GO:0034641 cellular nitrogen compound metabolic process
1.18 7.27e-07 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.21 8.55e-07 GO:0030154 cell differentiation
1.16 1.20e-06 GO:0048856 anatomical structure development
1.47 1.25e-06 GO:0010648 negative regulation of cell communication
1.48 1.52e-06 GO:0009968 negative regulation of signal transduction
1.27 1.53e-06 GO:0009893 positive regulation of metabolic process
1.30 1.58e-06 GO:0010646 regulation of cell communication
1.51 1.58e-06 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.46 1.86e-06 GO:0023057 negative regulation of signaling
1.20 1.93e-06 GO:0090304 nucleic acid metabolic process
1.37 3.31e-06 GO:0051254 positive regulation of RNA metabolic process
1.37 3.76e-06 GO:0010628 positive regulation of gene expression
1.38 3.85e-06 GO:0032989 cellular component morphogenesis
1.42 5.89e-06 GO:0000904 cell morphogenesis involved in differentiation
1.22 6.14e-06 GO:0016070 RNA metabolic process
1.35 7.45e-06 GO:0009790 embryo development
1.21 1.02e-05 GO:0006464 protein modification process
1.41 1.09e-05 GO:0032990 cell part morphogenesis
1.17 1.42e-05 GO:0044267 cellular protein metabolic process
1.16 1.43e-05 GO:0048731 system development
1.41 1.44e-05 GO:0048858 cell projection morphogenesis
1.26 2.05e-05 GO:0031325 positive regulation of cellular metabolic process
1.36 2.32e-05 GO:0045893 positive regulation of transcription, DNA-dependent
1.44 2.40e-05 GO:0032583 regulation of gene-specific transcription
1.20 2.42e-05 GO:0010467 gene expression
1.20 3.42e-05 GO:0043412 macromolecule modification
1.40 4.53e-05 GO:0048585 negative regulation of response to stimulus
1.45 9.91e-05 GO:0016568 chromatin modification
1.29 1.02e-04 GO:0006351 transcription, DNA-dependent
1.33 1.04e-04 GO:0030182 neuron differentiation
1.42 1.18e-04 GO:0007409 axonogenesis
1.34 1.39e-04 GO:0030030 cell projection organization
1.75 1.60e-04 GO:0030111 regulation of Wnt receptor signaling pathway
1.13 1.74e-04 GO:0051179 localization
1.23 2.02e-04 GO:0051641 cellular localization
1.40 2.09e-04 GO:0048812 neuron projection morphogenesis
1.47 2.15e-04 GO:0007411 axon guidance
1.30 2.40e-04 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.16 2.47e-04 GO:0009058 biosynthetic process
1.40 2.55e-04 GO:0048667 cell morphogenesis involved in neuron differentiation
1.26 2.56e-04 GO:0032268 regulation of cellular protein metabolic process
1.19 2.87e-04 GO:0048583 regulation of response to stimulus
1.32 4.21e-04 GO:0007167 enzyme linked receptor protein signaling pathway
1.16 4.25e-04 GO:0044249 cellular biosynthetic process
1.20 4.43e-04 GO:0034645 cellular macromolecule biosynthetic process
1.25 4.70e-04 GO:0051246 regulation of protein metabolic process
1.42 5.95e-04 GO:0009792 embryo development ending in birth or egg hatching
1.31 6.29e-04 GO:0045595 regulation of cell differentiation
1.22 7.27e-04 GO:0033036 macromolecule localization
1.28 7.33e-04 GO:0051128 regulation of cellular component organization
1.32 7.38e-04 GO:0051276 chromosome organization
1.29 7.64e-04 GO:0010557 positive regulation of macromolecule biosynthetic process
1.42 7.87e-04 GO:0043009 chordate embryonic development
1.26 9.08e-04 GO:0048468 cell development
1.36 9.44e-04 GO:0031175 neuron projection development
1.43 1.02e-03 GO:0007389 pattern specification process
1.33 1.10e-03 GO:0048666 neuron development
1.28 1.13e-03 GO:0051173 positive regulation of nitrogen compound metabolic process
1.19 1.16e-03 GO:0009059 macromolecule biosynthetic process
1.27 1.29e-03 GO:0031328 positive regulation of cellular biosynthetic process
1.50 1.45e-03 GO:0090046 regulation of transcription regulator activity
1.36 1.61e-03 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.50 1.94e-03 GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
1.23 2.12e-03 GO:0008104 protein localization
1.25 2.22e-03 GO:0032774 RNA biosynthetic process
1.43 2.63e-03 GO:0060284 regulation of cell development
1.34 2.65e-03 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.43 2.74e-03 GO:0051098 regulation of binding
1.25 3.02e-03 GO:0050793 regulation of developmental process
1.26 3.64e-03 GO:0009891 positive regulation of biosynthetic process
1.20 4.25e-03 GO:0035556 intracellular signal transduction
1.23 4.59e-03 GO:0006793 phosphorus metabolic process
1.23 4.59e-03 GO:0006796 phosphate metabolic process
1.25 5.29e-03 GO:0008219 cell death
1.34 5.35e-03 GO:0006325 chromatin organization
1.59 6.34e-03 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
1.45 6.41e-03 GO:0051101 regulation of DNA binding
1.12 7.19e-03 GO:0007165 signal transduction
1.27 7.81e-03 GO:0012501 programmed cell death
1.25 8.50e-03 GO:0033554 cellular response to stress
1.25 8.95e-03 GO:0016265 death
1.81 9.78e-03 GO:0021915 neural tube development
1.40 1.04e-02 GO:0045597 positive regulation of cell differentiation
1.33 1.38e-02 GO:0048646 anatomical structure formation involved in morphogenesis
1.10 1.53e-02 GO:0051716 cellular response to stimulus
1.51 1.65e-02 GO:0032582 negative regulation of gene-specific transcription
1.25 1.69e-02 GO:0046907 intracellular transport
2.36 1.74e-02 GO:0010717 regulation of epithelial to mesenchymal transition
1.92 1.91e-02 GO:0001838 embryonic epithelial tube formation
2.10 1.93e-02 GO:0030177 positive regulation of Wnt receptor signaling pathway
1.76 2.15e-02 GO:0060828 regulation of canonical Wnt receptor signaling pathway
1.32 2.56e-02 GO:0072358 cardiovascular system development
1.32 2.56e-02 GO:0072359 circulatory system development
1.37 2.72e-02 GO:0007420 brain development
1.10 2.75e-02 GO:0023052 signaling
1.42 2.87e-02 GO:0010608 posttranscriptional regulation of gene expression
1.26 2.98e-02 GO:0006915 apoptosis
1.25 3.10e-02 GO:0016192 vesicle-mediated transport
1.46 3.18e-02 GO:0048011 nerve growth factor receptor signaling pathway
1.40 3.25e-02 GO:0051130 positive regulation of cellular component organization
1.20 3.26e-02 GO:0051649 establishment of localization in cell
1.36 3.27e-02 GO:0090066 regulation of anatomical structure size
1.89 3.31e-02 GO:0072175 epithelial tube formation
1.57 3.47e-02 GO:0051099 positive regulation of binding
1.12 3.52e-02 GO:0019538 protein metabolic process
1.35 3.62e-02 GO:0007264 small GTPase mediated signal transduction
1.45 3.74e-02 GO:0003002 regionalization
1.25 3.84e-02 GO:2000026 regulation of multicellular organismal development
1.12 4.03e-02 GO:0051234 establishment of localization
1.37 4.37e-02 GO:0032535 regulation of cellular component size
2.23 4.56e-02 GO:0090263 positive regulation of canonical Wnt receptor signaling pathway

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.12 6.88e-46 GO:0044424 intracellular part
1.12 5.82e-45 GO:0005622 intracellular
1.13 2.53e-32 GO:0043226 organelle
1.13 8.67e-32 GO:0043229 intracellular organelle
1.15 6.10e-31 GO:0005737 cytoplasm
1.14 1.35e-30 GO:0043227 membrane-bounded organelle
1.14 4.71e-30 GO:0043231 intracellular membrane-bounded organelle
1.18 1.39e-21 GO:0005634 nucleus
1.16 2.64e-19 GO:0044444 cytoplasmic part
1.16 1.87e-18 GO:0044446 intracellular organelle part
1.16 4.96e-18 GO:0044422 organelle part
1.28 1.47e-15 GO:0044428 nuclear part
1.04 1.35e-12 GO:0044464 cell part
1.04 1.51e-12 GO:0005623 cell
1.27 3.40e-12 GO:0031981 nuclear lumen
1.23 6.42e-11 GO:0070013 intracellular organelle lumen
1.24 1.23e-10 GO:0005829 cytosol
1.22 6.80e-10 GO:0043233 organelle lumen
1.21 1.01e-09 GO:0031974 membrane-enclosed lumen
1.29 1.51e-09 GO:0005654 nucleoplasm
1.77 3.75e-07 GO:0005912 adherens junction
1.34 9.22e-07 GO:0044451 nucleoplasm part
1.70 2.40e-06 GO:0070161 anchoring junction
1.15 1.24e-05 GO:0043234 protein complex
1.17 1.71e-05 GO:0031090 organelle membrane
1.18 5.36e-04 GO:0012505 endomembrane system
1.11 1.11e-03 GO:0032991 macromolecular complex
1.22 1.47e-03 GO:0005794 Golgi apparatus
1.44 2.38e-03 GO:0005667 transcription factor complex
1.87 3.76e-03 GO:0031256 leading edge membrane
1.68 4.58e-03 GO:0005925 focal adhesion
1.66 5.02e-03 GO:0005924 cell-substrate adherens junction
1.49 6.36e-03 GO:0031252 cell leading edge
1.25 6.91e-03 GO:0015630 microtubule cytoskeleton
1.63 9.03e-03 GO:0030055 cell-substrate junction
1.45 1.25e-02 GO:0005911 cell-cell junction
1.26 1.63e-02 GO:0044431 Golgi apparatus part
1.11 1.90e-02 GO:0043228 non-membrane-bounded organelle
1.11 1.90e-02 GO:0043232 intracellular non-membrane-bounded organelle
1.32 3.29e-02 GO:0048471 perinuclear region of cytoplasm
1.83 3.62e-02 GO:0031901 early endosome membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.16 8.89e-29 GO:0005515 protein binding
1.09 6.08e-26 GO:0005488 binding
1.17 8.93e-10 GO:0003676 nucleic acid binding
1.21 3.06e-09 GO:0003677 DNA binding
1.59 3.79e-08 GO:0008134 transcription factor binding
1.20 1.02e-07 GO:0000166 nucleotide binding
1.56 1.20e-07 GO:0016564 transcription repressor activity
1.30 3.64e-07 GO:0030528 transcription regulator activity
1.45 6.53e-07 GO:0019904 protein domain specific binding
1.19 1.25e-05 GO:0017076 purine nucleotide binding
1.20 1.28e-05 GO:0016740 transferase activity
1.27 1.97e-05 GO:0001071 nucleic acid binding transcription factor activity
1.27 1.97e-05 GO:0003700 sequence-specific DNA binding transcription factor activity
1.19 2.70e-05 GO:0032553 ribonucleotide binding
1.19 2.70e-05 GO:0032555 purine ribonucleotide binding
1.47 3.51e-05 GO:0016563 transcription activator activity
1.27 4.05e-05 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.19 4.92e-05 GO:0035639 purine ribonucleoside triphosphate binding
1.30 4.98e-05 GO:0016301 kinase activity
1.20 7.68e-05 GO:0030554 adenyl nucleotide binding
1.57 1.48e-04 GO:0010843 promoter binding
1.20 1.54e-04 GO:0032559 adenyl ribonucleotide binding
1.19 3.19e-04 GO:0005524 ATP binding
1.28 3.27e-04 GO:0019899 enzyme binding
1.54 3.78e-04 GO:0000975 regulatory region DNA binding
1.54 3.78e-04 GO:0001067 regulatory region nucleic acid binding
1.54 3.78e-04 GO:0044212 transcription regulatory region DNA binding
1.28 4.55e-04 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.28 1.15e-03 GO:0043565 sequence-specific DNA binding
1.08 3.28e-03 GO:0003824 catalytic activity
1.76 6.04e-03 GO:0003705 sequence-specific enhancer binding RNA polymerase II transcription factor activity
1.54 6.40e-03 GO:0004721 phosphoprotein phosphatase activity
1.32 9.04e-03 GO:0004674 protein serine/threonine kinase activity
1.27 1.06e-02 GO:0004672 protein kinase activity
1.69 1.39e-02 GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
1.28 1.89e-02 GO:0008092 cytoskeletal protein binding
1.89 2.24e-02 GO:0008301 DNA bending activity
1.46 3.06e-02 GO:0043566 structure-specific DNA binding
1.40 4.00e-02 GO:0016791 phosphatase activity
1.13 4.18e-02 GO:0008270 zinc ion binding