Motif ID: TLX2.p2

Z-value: 1.571


Transcription factors associated with TLX2.p2:

Gene SymbolEntrez IDGene Name
TLX2 3196 T-cell leukemia homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TLX2chr2_+_74595073-0.543.1e-02Click!


Activity profile for motif TLX2.p2.

activity profile for motif TLX2.p2


Sorted Z-values histogram for motif TLX2.p2

Sorted Z-values for motif TLX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_+_54104383 2.244 NM_001161576
NM_015589
SAMD4A

sterile alpha motif domain containing 4A

chr3_+_153469421 1.506 MBNL1
muscleblind-like (Drosophila)
chr4_+_95592067 1.470 PDLIM5
PDZ and LIM domain 5
chr12_-_9123126 1.400 A2M
alpha-2-macroglobulin
chr7_+_106596641 1.382 NM_012257
HBP1
HMG-box transcription factor 1
chr14_+_34521945 1.253 SRP54
signal recognition particle 54kDa
chr4_+_95592030 1.161 NM_001011513
NM_001011515
NM_001011516
NM_006457
PDLIM5



PDZ and LIM domain 5



chr12_+_68150332 1.138 NM_001042555
NM_006654
FRS2

fibroblast growth factor receptor substrate 2

chr2_+_172252194 1.107 NM_001378
DYNC1I2
dynein, cytoplasmic 1, intermediate chain 2
chr10_-_90702490 1.099 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr14_+_54104099 1.091 SAMD4A
sterile alpha motif domain containing 4A
chr14_+_34521854 1.081 NM_001146282
NM_003136
SRP54

signal recognition particle 54kDa

chr2_-_63669265 1.074 NM_015910
WDPCP
WD repeat containing planar cell polarity effector
chr20_-_14266200 1.074 NM_013281
NM_198391
FLRT3

fibronectin leucine rich transmembrane protein 3

chr2_+_187163232 1.047 ITGAV
integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
chr12_+_105873669 1.040 NM_152261
C12orf23
chromosome 12 open reading frame 23
chr13_+_25726755 1.040 NM_001260
CDK8
cyclin-dependent kinase 8
chr3_-_153470022 1.035 LOC401093
hypothetical LOC401093
chr2_+_63669596 1.025 NM_005917
MDH1
malate dehydrogenase 1, NAD (soluble)
chr1_+_183281173 1.016 NM_007212
RNF2
ring finger protein 2
chr11_+_34894688 1.007 PDHX
pyruvate dehydrogenase complex, component X
chr20_+_43283423 0.979 NM_003008
SEMG2
semenogelin II
chr4_-_75938710 0.960 NM_001729
BTC
betacellulin
chr21_+_17841297 0.941 CXADR
coxsackie virus and adenovirus receptor
chr14_-_35859545 0.935 NM_001144891
NM_016586
MBIP

MAP3K12 binding inhibitory protein 1

chr2_-_160277083 0.922 BAZ2B
bromodomain adjacent to zinc finger domain, 2B
chr2_-_74460933 0.912 NM_001135040
NM_001190837
NM_004082
DCTN1


dynactin 1


chr16_+_51722285 0.912 CHD9
chromodomain helicase DNA binding protein 9
chr1_-_92537087 0.908 NM_053274
GLMN
glomulin, FKBP associated protein
chr4_+_38545741 0.889 NM_138389
FAM114A1
family with sequence similarity 114, member A1
chr2_+_207215386 0.887 NM_001102659
LOC200726
hCG1657980
chr2_+_228386800 0.886 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr6_+_117910472 0.875 NM_173674
DCBLD1
discoidin, CUB and LCCL domain containing 1
chr17_+_64020120 0.860 NM_002734
NM_212472
PRKAR1A

protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)

chr2_+_223433919 0.848 NM_004457
NM_203372
ACSL3

acyl-CoA synthetase long-chain family member 3

chr13_+_96797290 0.847


chr20_+_56318415 0.837 RAB22A
RAB22A, member RAS oncogene family
chr14_+_30098079 0.836 NM_017769
G2E3
G2/M-phase specific E3 ubiquitin protein ligase
chr13_-_40491491 0.834 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr11_+_12652427 0.827 NM_021961
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr6_+_131190237 0.826 NM_001195597
LOC285733
hypothetical LOC285733
chr2_+_187162969 0.826 NM_001145000
NM_002210
ITGAV

integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)

chr20_+_52258023 0.816 PFDN4
prefoldin subunit 4
chr8_-_125785611 0.810 MTSS1
metastasis suppressor 1
chr20_-_13713509 0.810 NM_016649
ESF1
ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
chr1_-_151045730 0.808 NM_178351
LCE1C
late cornified envelope 1C
chr20_+_45564063 0.805 NCOA3
nuclear receptor coactivator 3
chr2_+_219141761 0.803 NM_005444
RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr6_+_28217590 0.802 NM_006298
ZNF192
zinc finger protein 192
chr17_+_64020155 0.797 PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
chr6_+_160068135 0.796 NM_004906
NM_152858
WTAP

Wilms tumor 1 associated protein

chr11_+_8660913 0.789 RPL27A
ribosomal protein L27a
chr3_+_189425886 0.788 NM_001167671
LPP
LIM domain containing preferred translocation partner in lipoma
chr2_-_79168626 0.786 NM_006507
REG1B
regenerating islet-derived 1 beta
chr2_+_231629839 0.782 PSMD1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr18_+_17575542 0.782 NM_020774
MIB1
mindbomb homolog 1 (Drosophila)
chr2_+_113479919 0.779 NM_014440
IL1F6
interleukin 1 family, member 6 (epsilon)
chr1_+_24158898 0.778 PNRC2
proline-rich nuclear receptor coactivator 2
chr6_+_163904564 0.763 QKI
quaking homolog, KH domain RNA binding (mouse)
chr8_+_120289735 0.762 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr3_-_114176401 0.760 NM_138806
NM_138939
NM_138940
NM_170780
CD200R1



CD200 receptor 1



chr1_+_86662356 0.757 NM_006536
CLCA2
chloride channel accessory 2
chr2_-_40593074 0.756 NM_001112802
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr2_+_231629806 0.755 NM_001191037
NM_002807
PSMD1

proteasome (prosome, macropain) 26S subunit, non-ATPase, 1

chr14_-_22610610 0.754 NM_001164816
NM_001164817
ACIN1

apoptotic chromatin condensation inducer 1

chr3_-_107070400 0.744 NM_170662
CBLB
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
chr10_+_82163568 0.743 C10orf58
chromosome 10 open reading frame 58
chr20_+_13713645 0.741 NM_001039375
NM_024120
C20orf7

chromosome 20 open reading frame 7

chr17_+_64020159 0.737 PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
chr6_-_32839244 0.732 NM_001198858
HLA-DQB2
major histocompatibility complex, class II, DQ beta 2
chr12_+_55808696 0.726 LRP1
low density lipoprotein receptor-related protein 1
chr20_+_45564007 0.724 NM_001174087
NM_001174088
NM_006534
NM_181659
NCOA3



nuclear receptor coactivator 3



chr13_-_40491405 0.715 ELF1
E74-like factor 1 (ets domain transcription factor)
chr20_+_42463279 0.712 NM_000457
NM_178849
NM_178850
HNF4A


hepatocyte nuclear factor 4, alpha


chr17_+_55269974 0.711


chr16_+_5061862 0.711 ALG1
asparagine-linked glycosylation 1, beta-1,4-mannosyltransferase homolog (S. cerevisiae)
chr6_+_55300225 0.707 NM_207410
GFRAL
GDNF family receptor alpha like
chr15_-_75135496 0.706 TSPAN3
tetraspanin 3
chr20_+_42463419 0.704 HNF4A
hepatocyte nuclear factor 4, alpha
chr21_+_37367432 0.702 NM_001001894
TTC3
tetratricopeptide repeat domain 3
chr1_+_195123766 0.698 NM_006684
CFHR4
complement factor H-related 4
chr3_+_180853473 0.698 NM_003940
USP13
ubiquitin specific peptidase 13 (isopeptidase T-3)
chr14_+_75688042 0.693 C14orf118
chromosome 14 open reading frame 118
chr9_-_124715392 0.691 NM_006626
ZBTB6
zinc finger and BTB domain containing 6
chr7_+_90063543 0.690 CDK14
cyclin-dependent kinase 14
chr11_-_26550243 0.688 NM_001135091
NM_001135092
NM_145650
MUC15


mucin 15, cell surface associated


chr4_-_146315341 0.688 NM_017493
OTUD4
OTU domain containing 4
chr14_-_22610572 0.682 ACIN1
apoptotic chromatin condensation inducer 1
chr1_+_24158887 0.681 NM_017761
PNRC2
proline-rich nuclear receptor coactivator 2
chr3_+_197951203 0.679 PAK2
p21 protein (Cdc42/Rac)-activated kinase 2
chr7_+_130663161 0.677 MKLN1
muskelin 1, intracellular mediator containing kelch motifs
chr10_+_88506320 0.676 NM_004329
BMPR1A
bone morphogenetic protein receptor, type IA
chr6_-_58395610 0.676 GUSBP4
glucuronidase, beta pseudogene 4
chr10_+_114700775 0.672 TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr8_-_101384633 0.672 NM_015435
RNF19A
ring finger protein 19A
chr2_+_27848085 0.667 NM_004891
NM_145330
MRPL33

mitochondrial ribosomal protein L33

chr2_+_27848090 0.666 MRPL33
mitochondrial ribosomal protein L33
chr20_+_42463350 0.666 HNF4A
hepatocyte nuclear factor 4, alpha
chr6_+_7052798 0.664 NM_001168344
RREB1
ras responsive element binding protein 1
chr2_+_182464910 0.663 SSFA2
sperm specific antigen 2
chr14_+_75687997 0.656 NM_017926
NM_017972
C14orf118

chromosome 14 open reading frame 118

chr2_+_32244406 0.651 NM_001193513
NM_001193514
NM_001193515
NM_017964
SLC30A6



solute carrier family 30 (zinc transporter), member 6



chr1_+_114273961 0.646 HIPK1
homeodomain interacting protein kinase 1
chr19_-_56726704 0.642 NM_001177547
NM_001177548
NM_001177549
NM_001245
NM_198845
NM_198846
SIGLEC6





sialic acid binding Ig-like lectin 6





chr3_+_87359088 0.640 NM_014043
CHMP2B
chromatin modifying protein 2B
chr20_+_42463387 0.639 HNF4A
hepatocyte nuclear factor 4, alpha
chr14_+_75688025 0.638 C14orf118
chromosome 14 open reading frame 118
chr5_+_146594718 0.636 NM_001112724
NM_145001
STK32A

serine/threonine kinase 32A

chr6_+_124166767 0.636 NM_001040214
NM_153355
NKAIN2

Na+/K+ transporting ATPase interacting 2

chr20_+_43269051 0.634 NM_003007
SEMG1
semenogelin I
chr1_+_208178160 0.631 NM_001146261
NM_001146262
NM_001146264
NM_153262
SYT14



synaptotagmin XIV



chr20_+_52257800 0.631 NM_002623
PFDN4
prefoldin subunit 4
chr6_+_117109042 0.624 NM_002269
KPNA5
karyopherin alpha 5 (importin alpha 6)
chr10_+_123862430 0.623 TACC2
transforming, acidic coiled-coil containing protein 2
chr15_+_46285789 0.622 NM_000338
NM_001184832
SLC12A1

solute carrier family 12 (sodium/potassium/chloride transporters), member 1

chr20_+_42947764 0.622 YWHAB
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
chr16_+_55963899 0.621 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr7_-_80386258 0.619 SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr7_+_130663134 0.616 NM_013255
MKLN1
muskelin 1, intracellular mediator containing kelch motifs
chr1_-_94779727 0.615 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr3_+_187813538 0.612 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr3_+_187813553 0.611 AHSG
alpha-2-HS-glycoprotein
chr14_-_24148658 0.610 NM_033423
GZMH
granzyme H (cathepsin G-like 2, protein h-CCPX)
chr17_+_19853200 0.609 SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr4_+_146250978 0.608 ABCE1
ATP-binding cassette, sub-family E (OABP), member 1
chr9_+_132579088 0.607 NM_007313
ABL1
c-abl oncogene 1, non-receptor tyrosine kinase
chr19_+_2818332 0.606 NM_024967
ZNF556
zinc finger protein 556
chr22_+_29974368 0.605 LIMK2
LIM domain kinase 2
chr3_-_15814678 0.604 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr3_+_12305336 0.602 NM_138711
PPARG
peroxisome proliferator-activated receptor gamma
chr14_+_38804226 0.597 NM_203354
CTAGE5
CTAGE family, member 5
chr13_+_40783340 0.595 NM_001110798
NM_024561
NM_018527
NAA16


N(alpha)-acetyltransferase 16, NatA auxiliary subunit


chr4_+_38722593 0.594 NM_001007075
NM_001171654
KLHL5

kelch-like 5 (Drosophila)

chr4_+_123311207 0.593 NM_015312
KIAA1109
KIAA1109
chr2_+_231629869 0.589 PSMD1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr16_+_55963883 0.588 CX3CL1
chemokine (C-X3-C motif) ligand 1
chr20_-_61028263 0.587 DIDO1
death inducer-obliterator 1
chr5_+_149845503 0.587 NDST1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr18_+_17575275 0.586 MIB1
mindbomb homolog 1 (Drosophila)
chr21_+_29592984 0.585 BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr14_+_88099443 0.585 NM_207661
ZC3H14
zinc finger CCCH-type containing 14
chr12_-_48508411 0.585 NM_001037806
NCKAP5L
NCK-associated protein 5-like
chrX_+_154097894 0.581 NM_003372
VBP1
von Hippel-Lindau binding protein 1
chr6_+_147568795 0.578 STXBP5
syntaxin binding protein 5 (tomosyn)
chr21_+_29593088 0.574 NM_001186
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr20_-_61028287 0.573 DIDO1
death inducer-obliterator 1
chr2_+_160277219 0.571 NM_022826
MARCH7
membrane-associated ring finger (C3HC4) 7
chr1_+_84316217 0.570 NM_002731
NM_207578
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr3_+_187813405 0.569 AHSG
alpha-2-HS-glycoprotein
chr3_+_58452560 0.562 NM_001128214
KCTD6
potassium channel tetramerisation domain containing 6
chr15_+_38296920 0.560 NM_001128628
NM_001128629
PAK6

p21 protein (Cdc42/Rac)-activated kinase 6

chr11_-_22807842 0.560 NM_148893
SVIP
small VCP/p97-interacting protein
chr3_+_150330060 0.556 NM_032383
HPS3
Hermansky-Pudlak syndrome 3
chr21_+_29593607 0.556 NM_206866
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr2_-_210798232 0.555 NM_001608
ACADL
acyl-CoA dehydrogenase, long chain
chr14_+_64041170 0.554 ZBTB1
zinc finger and BTB domain containing 1
chr14_+_64041257 0.552 ZBTB1
zinc finger and BTB domain containing 1
chr2_+_231629852 0.552 PSMD1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr6_-_112186977 0.550 NM_153048
FYN
FYN oncogene related to SRC, FGR, YES
chr12_+_79995927 0.550 NM_024560
ACSS3
acyl-CoA synthetase short-chain family member 3
chr20_-_61028319 0.549 NM_001193369
NM_001193370
NM_080796
DIDO1


death inducer-obliterator 1


chr18_+_3237815 0.549 MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr2_+_160277273 0.549 MARCH7
membrane-associated ring finger (C3HC4) 7
chr12_+_67426225 0.546 SLC35E3
solute carrier family 35, member E3
chr3_-_21767819 0.544 NM_024697
ZNF385D
zinc finger protein 385D
chr13_+_59869427 0.542 NM_001146070
TDRD3
tudor domain containing 3
chr18_+_3237774 0.542 MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr12_+_84198015 0.542 NM_006982
ALX1
ALX homeobox 1
chr14_-_22825148 0.541 NM_020834
HOMEZ
homeobox and leucine zipper encoding
chr6_+_133177399 0.537 NM_001016
SNORA33
RPS12
small nucleolar RNA, H/ACA box 33
ribosomal protein S12
chr21_+_29593098 0.536 BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr3_+_153469206 0.535 MBNL1
muscleblind-like (Drosophila)
chr1_+_208178198 0.535 SYT14
synaptotagmin XIV
chr7_+_30034731 0.534 PLEKHA8P1
PLEKHA8
pleckstrin homology domain containing, family A member 8 pseudogene 1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8
chr6_+_64403936 0.532 PHF3
PHD finger protein 3
chr18_+_27332024 0.531 NM_001943
DSG2
desmoglein 2
chr16_-_66558197 0.525 NM_001145964
SLC12A4
solute carrier family 12 (potassium/chloride transporters), member 4
chr16_-_57309625 0.525 GOT2
glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)
chr8_-_82186832 0.524 NM_018440
PAG1
phosphoprotein associated with glycosphingolipid microdomains 1
chr5_-_13997588 0.522 NM_001369
DNAH5
dynein, axonemal, heavy chain 5
chr6_+_7053183 0.522 RREB1
ras responsive element binding protein 1
chr3_+_101462375 0.522 NM_018309
TBC1D23
TBC1 domain family, member 23
chr2_+_60962279 0.521 REL
v-rel reticuloendotheliosis viral oncogene homolog (avian)
chr3_+_140545528 0.520 NM_020191
MRPS22
mitochondrial ribosomal protein S22
chr14_-_22825072 0.518 HOMEZ
homeobox and leucine zipper encoding
chr10_+_31648103 0.517 NM_001174093
NM_001174095
NM_001174096
NM_030751
ZEB1



zinc finger E-box binding homeobox 1



chr3_+_4996141 0.516 BHLHE40
basic helix-loop-helix family, member e40
chr20_+_47328585 0.513 NCRNA00275
non-protein coding RNA 275
chr8_+_26491507 0.512 DPYSL2
dihydropyrimidinase-like 2
chr5_+_118434966 0.510 NM_005509
DMXL1
Dmx-like 1
chr3_+_4996305 0.509 BHLHE40
basic helix-loop-helix family, member e40
chr13_+_26029879 0.508 WASF3
WAS protein family, member 3
chr4_+_86968069 0.508 ARHGAP24
Rho GTPase activating protein 24
chr20_+_47328575 0.504 NCRNA00275
non-protein coding RNA 275
chr20_+_42947754 0.503 NM_003404
NM_139323
YWHAB

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide

chr20_-_1420168 0.502 NM_001122962
NM_001134836
SIRPB2

signal-regulatory protein beta 2

chr8_+_97575370 0.499 SDC2
syndecan 2
chr4_+_25931725 0.495 RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr14_+_23008742 0.495 NGDN
neuroguidin, EIF4E binding protein
chr2_+_152900076 0.495 FMNL2
formin-like 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
5.93 3.23e-02 GO:0006607 NLS-bearing substrate import into nucleus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.13 1.03e-04 GO:0005737 cytoplasm
1.16 1.45e-03 GO:0044422 organelle part
1.10 1.54e-03 GO:0043229 intracellular organelle
1.08 1.73e-03 GO:0044424 intracellular part
1.10 1.80e-03 GO:0043226 organelle
1.15 3.77e-03 GO:0044446 intracellular organelle part
1.07 4.89e-03 GO:0005622 intracellular
1.10 2.03e-02 GO:0043227 membrane-bounded organelle
1.10 2.05e-02 GO:0043231 intracellular membrane-bounded organelle
1.13 2.62e-02 GO:0044444 cytoplasmic part
1.24 3.27e-02 GO:0031974 membrane-enclosed lumen

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.14 3.07e-04 GO:0005515 protein binding
7.22 2.16e-02 GO:0019864 IgG binding