Motif ID: XBP1.p3

Z-value: 1.529


Transcription factors associated with XBP1.p3:

Gene SymbolEntrez IDGene Name
XBP1 7494 X-box binding protein 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
XBP1chr22_-_275265330.155.8e-01Click!


Activity profile for motif XBP1.p3.

activity profile for motif XBP1.p3


Sorted Z-values histogram for motif XBP1.p3

Sorted Z-values for motif XBP1.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of XBP1.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_173240983 3.622 NM_001135095
FNDC3B
fibronectin type III domain containing 3B
chr7_+_93861808 3.253 NM_000089
COL1A2
collagen, type I, alpha 2
chr2_+_171493870 3.245 NM_015530
GORASP2
golgi reassembly stacking protein 2, 55kDa
chr2_+_171494026 3.122 GORASP2
golgi reassembly stacking protein 2, 55kDa
chr5_+_126881207 2.838 NM_130809
PRRC1
proline-rich coiled-coil 1
chr20_+_32414715 2.657 NM_031483
ITCH
itchy E3 ubiquitin protein ligase homolog (mouse)
chr12_+_105873669 2.350 NM_152261
C12orf23
chromosome 12 open reading frame 23
chr6_+_144649142 2.262 UTRN
utrophin
chr7_+_128166581 2.186 NM_001130674
NM_001219
CALU

calumenin

chr4_+_38545741 2.029 NM_138389
FAM114A1
family with sequence similarity 114, member A1
chr12_+_105873803 1.977 C12orf23
chromosome 12 open reading frame 23
chr10_-_18988172 1.969


chr10_+_18988282 1.928 NM_178815
ARL5B
ADP-ribosylation factor-like 5B
chr6_+_7053183 1.874 RREB1
ras responsive element binding protein 1
chr7_+_128166631 1.785 CALU
calumenin
chr7_+_128166636 1.777 CALU
calumenin
chr14_+_38806028 1.733 NM_005930
NM_203355
CTAGE5

CTAGE family, member 5

chr7_+_128166664 1.728 CALU
calumenin
chr15_+_39739864 1.700 NM_001080541
NM_001164273
MGA

MAX gene associated

chr7_+_128166688 1.635 CALU
calumenin
chr15_+_39739933 1.570 MGA
MAX gene associated
chr3_-_107070400 1.532 NM_170662
CBLB
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
chr14_+_38806280 1.496 CTAGE5
CTAGE family, member 5
chr6_+_7052985 1.480 NM_001003698
NM_001003699
NM_001003700
RREB1


ras responsive element binding protein 1


chr11_+_117948350 1.467 ARCN1
archain 1
chr3_+_129253977 1.462 SEC61A1
Sec61 alpha 1 subunit (S. cerevisiae)
chr3_+_133861894 1.443 UBA5
ubiquitin-like modifier activating enzyme 5
chr3_+_129253997 1.437 SEC61A1
Sec61 alpha 1 subunit (S. cerevisiae)
chr11_+_117948301 1.420 NM_001142281
NM_001655
ARCN1

archain 1

chr14_+_30161267 1.419 NM_016106
NM_182835
SCFD1

sec1 family domain containing 1

chr3_+_129253816 1.377 NM_013336
SEC61A1
Sec61 alpha 1 subunit (S. cerevisiae)
chr10_+_104667991 1.364 NM_017649
NM_199076
NM_199077
CNNM2


cyclin M2


chr2_+_241903395 1.362 NM_001008491
NM_006155
SEPT2

septin 2

chr3_+_37259684 1.340 NM_001172713
NM_002078
GOLGA4

golgin A4

chr3_+_129254032 1.324


chr2_-_241903657 1.293 HDLBP
high density lipoprotein binding protein
chr8_-_9451439 1.289


chr6_-_116799548 1.272 LOC100287467
hypothetical LOC100287467
chr3_+_133861820 1.269 NM_024818
UBA5
ubiquitin-like modifier activating enzyme 5
chr10_+_89409332 1.267 NM_001015880
NM_004670
PAPSS2

3'-phosphoadenosine 5'-phosphosulfate synthase 2

chr9_+_113433364 1.260 NM_001015882
NM_004125
DNAJC25
DNAJC25-GNG10
DnaJ (Hsp40) homolog, subfamily C , member 25
DNAJC25-GNG10 readthrough
chr2_+_64604940 1.165 NM_001002243
NM_017657
NM_203437
AFTPH


aftiphilin


chr16_+_51722285 1.163 CHD9
chromodomain helicase DNA binding protein 9
chr3_+_133861425 1.142 UBA5
ubiquitin-like modifier activating enzyme 5
chr17_+_42355492 1.134 GOSR2
golgi SNAP receptor complex member 2
chr13_+_57105859 1.133 PCDH17
protocadherin 17
chr3_-_133861182 1.087 NM_032169
ACAD11
acyl-CoA dehydrogenase family, member 11
chr6_+_7052798 1.077 NM_001168344
RREB1
ras responsive element binding protein 1
chr1_+_220857774 1.077 NM_198551
MIA3
melanoma inhibitory activity family, member 3
chr4_+_76868763 1.013 USO1
USO1 vesicle docking protein homolog (yeast)
chr15_-_72952648 0.987 NM_005697
SCAMP2
secretory carrier membrane protein 2
chr5_+_115205515 0.985 NM_001284
AP3S1
adaptor-related protein complex 3, sigma 1 subunit
chr17_+_42355482 0.970 NM_001012511
NM_004287
NM_054022
GOSR2


golgi SNAP receptor complex member 2


chr4_-_76868581 0.944


chr2_+_64605049 0.936 AFTPH
aftiphilin
chr17_+_61729193 0.918 PRKCA
protein kinase C, alpha
chr4_+_76868850 0.906 NM_003715
USO1
USO1 vesicle docking protein homolog (yeast)
chr15_-_58477407 0.902 NM_001002857
NM_001002858
NM_001136015
NM_004039
ANXA2



annexin A2



chr4_+_129201933 0.880 LARP1B
La ribonucleoprotein domain family, member 1B
chr6_+_33276580 0.863 NM_001077516
NM_006979
SLC39A7

solute carrier family 39 (zinc transporter), member 7

chr9_+_37069882 0.846 LOC100506710
hypothetical LOC100506710
chr4_+_76868830 0.845 USO1
USO1 vesicle docking protein homolog (yeast)
chr5_+_115205472 0.833 AP3S1
adaptor-related protein complex 3, sigma 1 subunit
chr1_+_86943074 0.832 SH3GLB1
SH3-domain GRB2-like endophilin B1
chr3_+_124268545 0.825 NM_006810
PDIA5
protein disulfide isomerase family A, member 5
chr2_-_241860917 0.823 HDLBP
high density lipoprotein binding protein
chr6_+_37245860 0.816 NM_002648
PIM1
pim-1 oncogene
chr2_-_241860923 0.805 NM_203346
HDLBP
high density lipoprotein binding protein
chr6_-_33276416 0.797 RXRB
retinoid X receptor, beta
chr4_+_129201952 0.793 NM_018078
NM_032239
NM_178043
LARP1B


La ribonucleoprotein domain family, member 1B


chr2_+_173129022 0.792 NM_002610
PDK1
pyruvate dehydrogenase kinase, isozyme 1
chr12_-_97562532 0.785 NM_153687
NM_201612
NM_201613
IKBIP


IKBKB interacting protein


chrX_+_77246321 0.774 NM_000291
PGK1
phosphoglycerate kinase 1
chr6_-_33276426 0.764 RXRB
retinoid X receptor, beta
chr4_+_129201854 0.763 LARP1B
La ribonucleoprotein domain family, member 1B
chr5_+_92946348 0.747 NR2F1
nuclear receptor subfamily 2, group F, member 1
chr3_+_135007360 0.745 SRPRB
signal recognition particle receptor, B subunit
chr14_+_38805622 0.742 CTAGE5
CTAGE family, member 5
chr6_+_132170847 0.741 NM_006208
ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr2_-_241860871 0.734 HDLBP
high density lipoprotein binding protein
chr6_-_33276347 0.733 NM_021976
RXRB
retinoid X receptor, beta
chr19_+_47080285 0.728 NM_199002
ARHGEF1
Rho guanine nucleotide exchange factor (GEF) 1
chr14_+_101500650 0.716 DYNC1H1
dynein, cytoplasmic 1, heavy chain 1
chr3_+_135007326 0.712 SRPRB
signal recognition particle receptor, B subunit
chr13_+_44937025 0.708 NM_031431
COG3
component of oligomeric golgi complex 3
chr14_+_51525942 0.702 NM_016039
C14orf166
chromosome 14 open reading frame 166
chr16_+_55523526 0.699 HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr14_+_101500520 0.695 NM_001376
DYNC1H1
dynein, cytoplasmic 1, heavy chain 1
chr20_+_61054539 0.688 SLC17A9
solute carrier family 17, member 9
chr2_+_27109249 0.683 NM_001083590
NM_017727
TMEM214

transmembrane protein 214

chr16_-_80602546 0.676 NM_145168
SDR42E1
short chain dehydrogenase/reductase family 42E, member 1
chr2_+_136215611 0.671 NM_014607
UBXN4
UBX domain protein 4
chr14_-_38642165 0.670 NM_006364
SEC23A
Sec23 homolog A (S. cerevisiae)
chr20_-_17610828 0.657 NM_001042576
NM_004587
RRBP1

ribosome binding protein 1 homolog 180kDa (dog)

chr17_+_61729306 0.654 NM_002737
PRKCA
protein kinase C, alpha
chr14_+_51526071 0.638 C14orf166
chromosome 14 open reading frame 166
chr2_+_27109327 0.626 TMEM214
transmembrane protein 214
chr2_-_101134146 0.623 NM_001102426
TBC1D8
TBC1 domain family, member 8 (with GRAM domain)
chr14_-_38642029 0.611 SEC23A
Sec23 homolog A (S. cerevisiae)
chr2_+_27109341 0.611 TMEM214
transmembrane protein 214
chr12_+_67489063 0.596 MDM2
Mdm2 p53 binding protein homolog (mouse)
chr6_-_33276141 0.587 RXRB
retinoid X receptor, beta
chr11_+_32068990 0.579 NM_002901
RCN1
reticulocalbin 1, EF-hand calcium binding domain
chr1_+_109434896 0.573 NM_020141
TMEM167B
transmembrane protein 167B
chr2_+_233270286 0.571 GIGYF2
GRB10 interacting GYF protein 2
chr20_-_33144262 0.571 NM_015638
NM_199368
TRPC4AP

transient receptor potential cation channel, subfamily C, member 4 associated protein

chr14_+_30161285 0.570 SCFD1
sec1 family domain containing 1
chr11_+_32069183 0.560 RCN1
reticulocalbin 1, EF-hand calcium binding domain
chr2_+_183289205 0.557 NM_018981
DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr20_+_48241334 0.552 CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chr6_+_138524717 0.552 NM_020340
KIAA1244
KIAA1244
chr8_+_98725505 0.548 NM_178812
MTDH
metadherin
chr3_+_171167243 0.537 NM_003262
SEC62
SEC62 homolog (S. cerevisiae)
chr13_+_25726238 0.537 CDK8
cyclin-dependent kinase 8
chr22_-_29833484 0.519 NM_080430
SELM
selenoprotein M
chrX_+_152565849 0.517 DUSP9
dual specificity phosphatase 9
chr1_+_86943103 0.516 SH3GLB1
SH3-domain GRB2-like endophilin B1
chr20_-_17610704 0.515 RRBP1
ribosome binding protein 1 homolog 180kDa (dog)
chr8_+_98725604 0.513 MTDH
metadherin
chr3_+_101911051 0.512 NM_001195478
TFG
TRK-fused gene
chr17_+_52689372 0.509 NM_170721
MSI2
musashi homolog 2 (Drosophila)
chr20_+_61054443 0.507 NM_022082
SLC17A9
solute carrier family 17, member 9
chr6_+_132170888 0.504 ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr2_-_15618896 0.497 NM_015909
NBAS
neuroblastoma amplified sequence
chr2_+_233270275 0.492 GIGYF2
GRB10 interacting GYF protein 2
chr7_+_93862137 0.490 COL1A2
PLAG1
collagen, type I, alpha 2
pleiomorphic adenoma gene 1
chr3_-_120665113 0.489 NM_018266
TMEM39A
transmembrane protein 39A
chr16_-_30453499 0.486 ZNF747
zinc finger protein 747
chr2_-_241861175 0.477 HDLBP
high density lipoprotein binding protein
chr11_+_120399966 0.471 NM_001130047
NM_152715
TBCEL

tubulin folding cofactor E-like

chr1_+_86942810 0.465 NM_016009
SH3GLB1
SH3-domain GRB2-like endophilin B1
chr17_+_8279860 0.455 NM_001025579
NM_030808
NDEL1

nudE nuclear distribution gene E homolog (A. nidulans)-like 1

chr5_+_112224875 0.451 NM_003135
SRP19
signal recognition particle 19kDa
chr15_-_21444085 0.449 NM_019066
MAGEL2
MAGE-like 2
chr11_+_32561913 0.448 EIF3M
eukaryotic translation initiation factor 3, subunit M
chr2_-_15618865 0.444 NBAS
neuroblastoma amplified sequence
chr14_-_49157076 0.438 NM_001001
RPL36AL
ribosomal protein L36a-like
chr1_-_87152372 0.434 SEP15
15 kDa selenoprotein
chr14_+_49157150 0.433 NM_002408
MGAT2
mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr17_+_34279781 0.427 LASP1
LIM and SH3 protein 1
chr5_+_122138636 0.427 NM_003100
SNX2
sorting nexin 2
chr1_+_86942874 0.426 SH3GLB1
SH3-domain GRB2-like endophilin B1
chr11_+_65049152 0.423 SCYL1
SCY1-like 1 (S. cerevisiae)
chr2_-_20115269 0.412 NM_014713
LAPTM4A
lysosomal protein transmembrane 4 alpha
chr6_+_83959750 0.412 NM_033411
RWDD2A
RWD domain containing 2A
chr5_-_114965959 0.410 NM_021649
TICAM2
toll-like receptor adaptor molecule 2
chr11_+_113776504 0.407 RBM7
RNA binding motif protein 7
chr2_+_170392146 0.404 NM_172070
UBR3
ubiquitin protein ligase E3 component n-recognin 3 (putative)
chr6_-_83959640 0.403 NM_015599
PGM3
phosphoglucomutase 3
chr20_-_33144013 0.401 TRPC4AP
transient receptor potential cation channel, subfamily C, member 4 associated protein
chr5_+_122138677 0.399 SNX2
sorting nexin 2
chr2_+_75039273 0.396 NM_019896
POLE4
polymerase (DNA-directed), epsilon 4 (p12 subunit)
chr1_+_170768635 0.394 NM_014283
C1orf9
chromosome 1 open reading frame 9
chr1_+_110328955 0.392 AHCYL1
adenosylhomocysteinase-like 1
chr4_+_25931282 0.392 RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr17_+_34279835 0.381 LASP1
LIM and SH3 protein 1
chr11_+_65049102 0.381 NM_001048218
NM_020680
SCYL1

SCY1-like 1 (S. cerevisiae)

chr2_+_84986273 0.377 NM_021103
TMSB10
thymosin beta 10
chr10_+_92970302 0.375 NM_032373
PCGF5
polycomb group ring finger 5
chr11_+_65049552 0.369 SCYL1
SCY1-like 1 (S. cerevisiae)
chr2_+_220117009 0.368 TMEM198
transmembrane protein 198
chr11_+_113776582 0.366 NM_016090
RBM7
RNA binding motif protein 7
chr5_+_119827903 0.361 NM_016644
PRR16
proline rich 16
chr5_-_115205143 0.359 NM_004707
ATG12
ATG12 autophagy related 12 homolog (S. cerevisiae)
chr1_-_87152396 0.358 SEP15
15 kDa selenoprotein
chr12_-_97562836 0.352 IKBIP
IKBKB interacting protein
chr2_+_84986510 0.349 TMSB10
thymosin beta 10
chr10_+_98582005 0.345 NM_001170765
NM_001170766
LCOR

ligand dependent nuclear receptor corepressor

chr2_+_200528173 0.344 NM_024520
C2orf47
chromosome 2 open reading frame 47
chr19_+_54160369 0.342 NM_000146
FTL
ferritin, light polypeptide
chr17_+_30331579 0.337 NM_002311
NM_013975
LIG3

ligase III, DNA, ATP-dependent

chr9_+_99858762 0.336 NM_018946
NANS
N-acetylneuraminic acid synthase
chr3_+_101911083 0.334 TFG
TRK-fused gene
chr19_-_51608665 0.333 NM_032040
CCDC8
coiled-coil domain containing 8
chr1_+_109810743 0.331 SYPL2
synaptophysin-like 2
chr19_+_54160399 0.330 FTL
ferritin, light polypeptide
chr1_-_143643324 0.328 NM_001002811
PDE4DIP
phosphodiesterase 4D interacting protein
chr5_+_122138661 0.327 SNX2
sorting nexin 2
chr17_+_34279877 0.322 LASP1
LIM and SH3 protein 1
chr17_+_34279637 0.321 NM_006148
LASP1
LIM and SH3 protein 1
chr16_+_65143979 0.320 CKLF
chemokine-like factor
chr17_+_52688842 0.318 NM_138962
MSI2
musashi homolog 2 (Drosophila)
chr4_+_39734902 0.317 NM_018177
N4BP2
NEDD4 binding protein 2
chr2_+_233270241 0.315 NM_001103146
NM_001103147
NM_001103148
NM_015575
GIGYF2



GRB10 interacting GYF protein 2



chr10_+_114699953 0.313 NM_001146274
NM_001146283
NM_001146284
NM_001146285
NM_001146286
NM_001198525
NM_001198526
NM_001198527
NM_001198528
NM_001198529
NM_001198530
NM_001198531
NM_030756
TCF7L2












transcription factor 7-like 2 (T-cell specific, HMG-box)












chr2_-_20114881 0.312 LAPTM4A
lysosomal protein transmembrane 4 alpha
chr16_+_65143948 0.311 NM_001040138
NM_016326
NM_016951
NM_181640
NM_181641
CKLF




chemokine-like factor




chr5_+_118434620 0.311 DMXL1
Dmx-like 1
chr1_+_160797973 0.308 UAP1
UDP-N-acteylglucosamine pyrophosphorylase 1
chrX_+_77246430 0.306 PGK1
phosphoglycerate kinase 1
chr1_+_110329224 0.304 AHCYL1
adenosylhomocysteinase-like 1
chr7_+_16759845 0.303 NM_014399
TSPAN13
tetraspanin 13
chr3_+_101910823 0.302 NM_001007565
NM_001195479
NM_006070
TFG


TRK-fused gene


chr10_+_92970487 0.301 PCGF5
polycomb group ring finger 5
chr2_+_136215806 0.300 UBXN4
UBX domain protein 4
chr14_-_22904239 0.299 EFS
embryonal Fyn-associated substrate
chr11_+_32561931 0.297 NM_006360
EIF3M
eukaryotic translation initiation factor 3, subunit M
chr3_-_180651874 0.292 GNB4
guanine nucleotide binding protein (G protein), beta polypeptide 4
chr7_+_127079466 0.289 SND1
staphylococcal nuclease and tudor domain containing 1
chr1_+_170768914 0.285 NM_016227
C1orf9
chromosome 1 open reading frame 9

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
6.03 1.24e-06 GO:0048193 Golgi vesicle transport
2.53 1.23e-04 GO:0016192 vesicle-mediated transport
6.25 1.74e-04 GO:0006487 protein N-linked glycosylation
2.42 4.02e-04 GO:0046907 intracellular transport
6.17 6.08e-04 GO:0018196 peptidyl-asparagine modification
6.17 6.08e-04 GO:0018279 protein N-linked glycosylation via asparagine
2.30 7.05e-04 GO:0045184 establishment of protein localization
2.12 8.52e-04 GO:0051649 establishment of localization in cell
2.29 1.16e-03 GO:0015031 protein transport
3.92 2.13e-03 GO:0009101 glycoprotein biosynthetic process
2.82 2.60e-03 GO:0044262 cellular carbohydrate metabolic process
1.94 3.91e-03 GO:0033036 macromolecule localization
4.12 4.61e-03 GO:0006486 protein glycosylation
4.12 4.61e-03 GO:0043413 macromolecule glycosylation
4.10 4.98e-03 GO:0070085 glycosylation
12.64 6.26e-03 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER
4.00 6.73e-03 GO:0043687 post-translational protein modification
1.93 6.75e-03 GO:0051641 cellular localization
2.01 9.69e-03 GO:0008104 protein localization
2.80 1.16e-02 GO:0006886 intracellular protein transport
3.19 3.31e-02 GO:0009100 glycoprotein metabolic process
3.42 4.33e-02 GO:0006457 protein folding

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.43 4.78e-13 GO:0005737 cytoplasm
2.88 6.28e-13 GO:0005783 endoplasmic reticulum
1.26 9.95e-12 GO:0005622 intracellular
3.13 9.92e-11 GO:0044432 endoplasmic reticulum part
1.26 1.20e-10 GO:0044424 intracellular part
1.53 1.97e-10 GO:0044444 cytoplasmic part
2.09 3.74e-10 GO:0031090 organelle membrane
2.29 7.96e-10 GO:0012505 endomembrane system
2.82 5.18e-07 GO:0005789 endoplasmic reticulum membrane
2.76 1.01e-06 GO:0042175 nuclear membrane-endoplasmic reticulum network
1.44 2.62e-06 GO:0044446 intracellular organelle part
1.26 2.76e-06 GO:0043229 intracellular organelle
1.25 3.42e-06 GO:0043226 organelle
1.29 3.86e-06 GO:0043231 intracellular membrane-bounded organelle
1.28 4.35e-06 GO:0043227 membrane-bounded organelle
1.43 4.39e-06 GO:0044422 organelle part
2.34 6.35e-06 GO:0005794 Golgi apparatus
2.71 4.54e-04 GO:0000139 Golgi membrane
6.70 5.08e-04 GO:0030117 membrane coat
6.70 5.08e-04 GO:0048475 coated membrane
5.36 5.66e-04 GO:0005788 endoplasmic reticulum lumen
1.09 6.34e-04 GO:0044464 cell part
1.09 6.44e-04 GO:0005623 cell
2.25 9.24e-04 GO:0031410 cytoplasmic vesicle
2.26 1.53e-03 GO:0016023 cytoplasmic membrane-bounded vesicle
2.18 1.92e-03 GO:0031982 vesicle
2.22 2.29e-03 GO:0031988 membrane-bounded vesicle
15.80 2.34e-03 GO:0030663 COPI coated vesicle membrane
7.94 5.65e-03 GO:0030120 vesicle coat
3.08 6.25e-03 GO:0030659 cytoplasmic vesicle membrane
2.30 6.74e-03 GO:0044431 Golgi apparatus part
13.01 6.84e-03 GO:0030137 COPI-coated vesicle
2.97 9.81e-03 GO:0012506 vesicle membrane
8.29 1.70e-02 GO:0030660 Golgi-associated vesicle membrane
14.74 2.65e-02 GO:0030126 COPI vesicle coat
5.73 4.87e-02 GO:0005798 Golgi-associated vesicle

Nothing significant found in function category.