Motif ID: ZEB1.p2

Z-value: 1.309


Transcription factors associated with ZEB1.p2:

Gene SymbolEntrez IDGene Name
ZEB1 6935 zinc finger E-box binding homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ZEB1chr10_+_31650069-0.312.5e-01Click!


Activity profile for motif ZEB1.p2.

activity profile for motif ZEB1.p2


Sorted Z-values histogram for motif ZEB1.p2

Sorted Z-values for motif ZEB1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZEB1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_43447078 3.018 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr19_+_43446937 2.822 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr19_+_43447262 2.681 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr22_+_38720881 2.131 NM_138435
FAM83F
family with sequence similarity 83, member F
chr4_+_75529716 1.511 NM_001657
AREG
amphiregulin
chr4_+_75699652 1.261 NM_001657
AREG
amphiregulin
chr21_+_36993302 1.220


chr12_+_131797455 1.052 NM_001170543
NM_001170544
NM_138575
PGAM5


phosphoglycerate mutase family member 5


chr7_+_1536847 1.020 NM_002360
MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr2_+_10779191 0.901 NM_001039362
NM_144583
ATP6V1C2

ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2

chr14_-_105392671 0.890


chr19_+_6415259 0.805 NM_139161
NM_174881
CRB3

crumbs homolog 3 (Drosophila)

chr16_+_270606 0.802 NM_001176
ARHGDIG
Rho GDP dissociation inhibitor (GDI) gamma
chr1_-_16812274 0.781 NM_017940
NBPF1
neuroblastoma breakpoint family, member 1
chrX_+_48915127 0.781 NM_002668
PLP2
proteolipid protein 2 (colonic epithelium-enriched)
chr7_-_130891861 0.773 NM_001018111
NM_005397
PODXL

podocalyxin-like

chr19_-_51690989 0.726 NM_020709
PNMAL2
PNMA-like 2
chr12_+_6179736 0.722 NM_001769
CD9
CD9 molecule
chr9_-_139060416 0.720 NM_015392
NPDC1
neural proliferation, differentiation and control, 1
chr19_+_590878 0.711 NM_020637
FGF22
fibroblast growth factor 22
chr9_-_139060377 0.711 NPDC1
neural proliferation, differentiation and control, 1
chr16_+_87232501 0.687 NM_013278
IL17C
interleukin 17C
chr5_+_167651063 0.685 NM_001161661
NM_001161662
NM_015238
WWC1


WW and C2 domain containing 1


chrX_-_30817329 0.674 NM_152787
TAB3
TGF-beta activated kinase 1/MAP3K7 binding protein 3
chr9_+_132874324 0.650 NM_006059
LAMC3
laminin, gamma 3
chr9_-_139060285 0.650 NPDC1
neural proliferation, differentiation and control, 1
chr3_+_53170254 0.647 NM_006254
NM_212539
PRKCD

protein kinase C, delta

chr19_+_7566698 0.644 NM_001080429
NM_020902
KIAA1543

KIAA1543

chrX_-_13866565 0.642 NM_001001994
GPM6B
glycoprotein M6B
chr9_+_37640996 0.632 NM_014907
FRMPD1
FERM and PDZ domain containing 1
chr21_+_36993860 0.596 NM_005069
NM_009586
SIM2

single-minded homolog 2 (Drosophila)

chr14_+_73775927 0.593 NM_182894
VSX2
visual system homeobox 2
chr17_-_76064842 0.590 NM_002522
NPTX1
neuronal pentraxin I
chr19_-_1083109 0.583 NM_001100122
SBNO2
strawberry notch homolog 2 (Drosophila)
chr9_-_125070675 0.579 NM_001171137
STRBP
spermatid perinuclear RNA binding protein
chr17_-_77634455 0.565 FASN
fatty acid synthase
chr18_+_75724655 0.562 NM_012283
KCNG2
potassium voltage-gated channel, subfamily G, member 2
chr9_+_138900760 0.552 NM_021138
TRAF2
TNF receptor-associated factor 2
chr13_+_26896614 0.550 NM_002097
GTF3A
general transcription factor IIIA
chr17_+_71229110 0.549 NM_000213
NM_001005731
ITGB4

integrin, beta 4

chr15_-_53822468 0.543 NM_173814
PRTG
protogenin
chr19_-_1518875 0.541 NM_001174118
NM_203304
MEX3D

mex-3 homolog D (C. elegans)

chr17_+_21220260 0.535 NM_021012
KCNJ12
potassium inwardly-rectifying channel, subfamily J, member 12
chrX_+_151991474 0.531 NM_001170944
NM_032882
LOC100287428
PNMA6A
paraneoplastic antigen-like protein 6A related gene
paraneoplastic antigen like 6A
chr17_+_71229151 0.525 ITGB4
integrin, beta 4
chr6_-_3172775 0.522 NM_178012
TUBB2B
tubulin, beta 2B
chr18_+_59295123 0.520 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr9_-_92444886 0.519 NM_017594
DIRAS2
DIRAS family, GTP-binding RAS-like 2
chr17_+_71229191 0.514 ITGB4
integrin, beta 4
chr22_+_18081968 0.511 NM_002688
SEPT5
septin 5
chr5_-_1348103 0.509 NM_001193376
NM_198253
TERT

telomerase reverse transcriptase

chr19_-_17793312 0.506 NM_005543
INSL3
insulin-like 3 (Leydig cell)
chr19_-_17217022 0.506 NM_005234
NR2F6
nuclear receptor subfamily 2, group F, member 6
chrX_+_149280486 0.504 MAMLD1
mastermind-like domain containing 1
chr17_-_77635703 0.502 FASN
fatty acid synthase
chr19_+_51498695 0.498 NM_152794
HIF3A
hypoxia inducible factor 3, alpha subunit
chr19_-_45016587 0.495 NM_004714
NM_006483
NM_006484
DYRK1B


dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B


chr9_+_125813849 0.491 LHX2
LIM homeobox 2
chr22_-_22422951 0.488 NM_021916
ZNF70
zinc finger protein 70
chr17_-_76811297 0.482 NM_001009811
NM_014984
AZI1

5-azacytidine induced 1

chrX_+_130019896 0.481 NM_144967
ARHGAP36
Rho GTPase activating protein 36
chr10_-_133971136 0.481 NM_173575
STK32C
serine/threonine kinase 32C
chrX_-_17789276 0.478 NM_001172732
NM_001172739
NM_001172743
NM_021785
RAI2



retinoic acid induced 2



chr22_-_40408331 0.478 NM_005008
NHP2L1
NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
chr4_-_8211335 0.475 NM_001130083
NM_001130084
NM_001130085
NM_001130086
NM_001130087
NM_001130088
NM_032432
ABLIM2






actin binding LIM protein family, member 2






chr7_-_45927263 0.472 NM_000598
NM_001013398
IGFBP3

insulin-like growth factor binding protein 3

chr11_-_550706 0.470 NM_173573
C11orf35
chromosome 11 open reading frame 35
chr9_-_125070613 0.464 NM_018387
STRBP
spermatid perinuclear RNA binding protein
chr22_+_18124225 0.462 NM_005992
NM_080646
NM_080647
TBX1


T-box 1


chr5_+_665454 0.458 CEP72
centrosomal protein 72kDa
chr17_+_7393098 0.457 NM_172089
NM_003809
TNFSF12-TNFSF13
TNFSF12
TNFSF12-TNFSF13 readthrough
tumor necrosis factor (ligand) superfamily, member 12
chr18_-_45975163 0.456 NM_001080467
MYO5B
myosin VB
chr3_-_198839026 0.453 LOC220729
succinate dehydrogenase complex, subunit A, flavoprotein pseudogene
chrX_+_47305459 0.453 NM_001654
ARAF
v-raf murine sarcoma 3611 viral oncogene homolog
chr19_-_43406621 0.452 NM_001135155
NM_004647
DPF1

D4, zinc and double PHD fingers family 1

chrX_-_13866451 0.451 GPM6B
glycoprotein M6B
chr22_-_41419800 0.449 A4GALT
alpha 1,4-galactosyltransferase
chrX_+_130985316 0.442 NM_001042452
MST4
serine/threonine protein kinase MST4
chr12_-_116112495 0.442 NM_015002
NM_033624
FBXO21

F-box protein 21

chr11_+_12088639 0.436 NM_014632
MICAL2
microtubule associated monoxygenase, calponin and LIM domain containing 2
chr7_+_45163891 0.436 NM_005856
RAMP3
receptor (G protein-coupled) activity modifying protein 3
chr1_+_204390905 0.434 NM_000707
AVPR1B
arginine vasopressin receptor 1B
chrX_-_152804731 0.432 L1CAM
L1 cell adhesion molecule
chr8_-_143482433 0.432 NM_145003
TSNARE1
t-SNARE domain containing 1
chr2_+_74595073 0.427 NM_016170
TLX2
T-cell leukemia homeobox 2
chr16_+_4415805 0.426 NM_001135110
NM_005147
DNAJA3

DnaJ (Hsp40) homolog, subfamily A, member 3

chr5_+_665404 0.423 NM_018140
CEP72
centrosomal protein 72kDa
chr6_+_47553399 0.420 NM_012120
CD2AP
CD2-associated protein
chr1_+_61980679 0.418 NM_176877
INADL
InaD-like (Drosophila)
chr8_+_145393450 0.416 NM_001008271
NM_001080514
SCXA
SCXB
scleraxis homolog A (mouse)
scleraxis homolog B (mouse)
chrX_+_151557292 0.415 NM_018558
GABRQ
gamma-aminobutyric acid (GABA) receptor, theta
chr12_+_53229625 0.414 PDE1B
phosphodiesterase 1B, calmodulin-dependent
chr2_-_241408296 0.412 NM_004321
KIF1A
kinesin family member 1A
chr17_+_58908152 0.409 NM_000789
ACE
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
chr7_+_45580704 0.407 ADCY1
adenylate cyclase 1 (brain)
chr21_+_41719847 0.404 NM_002462
NM_001178046
MX1

myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)

chr15_-_100082134 0.403 NM_152334
TARSL2
threonyl-tRNA synthetase-like 2
chr19_+_18584666 0.401 NM_012109
TMEM59L
transmembrane protein 59-like
chr17_+_4434582 0.400 NM_001114974
SMTNL2
smoothelin-like 2
chr19_-_15421761 0.398 NM_021241
WIZ
widely interspaced zinc finger motifs
chr7_+_45580606 0.396 NM_021116
ADCY1
adenylate cyclase 1 (brain)
chr16_+_67236730 0.392 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr19_+_40431359 0.389 NM_015925
NM_205834
NM_205835
LSR


lipolysis stimulated lipoprotein receptor


chr22_-_19122047 0.386 SCARF2
scavenger receptor class F, member 2
chr8_-_144882679 0.385 FAM83H
family with sequence similarity 83, member H
chr8_-_144862266 0.385 NM_001162914
LOC100130274
coiled-coil domain containing 121-like
chr1_+_109594163 0.383 NM_001408
CELSR2
cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)
chr22_-_17489718 0.383 DGCR2
DiGeorge syndrome critical region gene 2
chr19_+_49972965 0.382 NM_001130852
NM_012116
CBLC

Cas-Br-M (murine) ecotropic retroviral transforming sequence c

chr17_-_8643163 0.382 NM_152599
MFSD6L
major facilitator superfamily domain containing 6-like
chr8_+_1699418 0.382 CLN8
ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
chr4_-_152155827 0.380 LRBA
LPS-responsive vesicle trafficking, beach and anchor containing
chr7_+_115637795 0.380 NM_015641
TES
testis derived transcript (3 LIM domains)
chr19_+_1033797 0.379 HMHA1
histocompatibility (minor) HA-1
chr16_+_88280569 0.378 NM_001098533
NM_001160367
NM_052987
NM_052988
CDK10



cyclin-dependent kinase 10



chr9_+_138900795 0.378 TRAF2
TNF receptor-associated factor 2
chr19_+_41039649 0.378 NM_032123
NM_199179
NM_199180
KIRREL2


kin of IRRE like 2 (Drosophila)


chr11_+_70841864 0.375 NM_018161
NADSYN1
NAD synthetase 1
chr1_+_1971762 0.374 NM_002744
PRKCZ
protein kinase C, zeta
chr20_+_25176698 0.374 NM_002862
PYGB
phosphorylase, glycogen; brain
chr1_-_6218554 0.373 ICMT
isoprenylcysteine carboxyl methyltransferase
chrX_+_48221323 0.372 NM_177434
FTSJ1
FtsJ homolog 1 (E. coli)
chr3_+_138965844 0.368 SOX14
SRY (sex determining region Y)-box 14
chr19_+_10392128 0.368 NM_001111307
PDE4A
phosphodiesterase 4A, cAMP-specific
chr7_+_5598979 0.367 NM_003088
FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr16_+_1668257 0.367 NM_144570
HN1L
hematological and neurological expressed 1-like
chrX_-_13866366 0.367


chr19_+_40431618 0.367 LSR
lipolysis stimulated lipoprotein receptor
chr11_+_70841910 0.366 NADSYN1
NAD synthetase 1
chr17_+_26060617 0.363


chrX_-_20044670 0.361 NM_001168467
MAP7D2
MAP7 domain containing 2
chr9_+_134447795 0.360 NM_020064
BARHL1
BarH-like homeobox 1
chr1_-_3556420 0.360 NM_017818
WDR8
WD repeat domain 8
chr1_+_37712716 0.356 ZC3H12A
zinc finger CCCH-type containing 12A
chr20_+_56159388 0.356 NM_178456
C20orf85
chromosome 20 open reading frame 85
chr14_+_64240902 0.355 NM_015549
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr21_+_41610530 0.355 NM_058186
NM_206964
FAM3B

family with sequence similarity 3, member B

chrX_+_68641802 0.355 NM_015686
FAM155B
family with sequence similarity 155, member B
chr12_+_53229443 0.353 NM_000924
PDE1B
phosphodiesterase 1B, calmodulin-dependent
chr11_+_63883192 0.350 NM_001006944
NM_003942
RPS6KA4

ribosomal protein S6 kinase, 90kDa, polypeptide 4

chr9_-_139183675 0.349


chrX_+_149612488 0.348 NM_003828
MTMR1
myotubularin related protein 1
chr11_+_66381077 0.348 LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr8_+_32525269 0.347 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
NRG1










neuregulin 1










chrX_-_109925941 0.347 NM_001143981
NM_001143982
NM_001143983
CHRDL1


chordin-like 1


chr15_-_81113676 0.346 NM_030594
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr3_-_8668723 0.344 NM_015931
C3orf32
chromosome 3 open reading frame 32
chr14_+_104402626 0.343 NM_001112726
NM_015005
KIAA0284

KIAA0284

chrX_-_67569894 0.342 NM_002547
OPHN1
oligophrenin 1
chr16_-_66007650 0.341 NM_013304
ZDHHC1
zinc finger, DHHC-type containing 1
chr3_-_184316553 0.341 MCCC1
methylcrotonoyl-CoA carboxylase 1 (alpha)
chr3_-_129690056 0.340 NM_001145661
GATA2
GATA binding protein 2
chr19_+_17843753 0.339 NM_000453
SLC5A5
solute carrier family 5 (sodium iodide symporter), member 5
chr1_+_37712767 0.338 ZC3H12A
zinc finger CCCH-type containing 12A
chr17_+_1905104 0.338 NM_006497
HIC1
hypermethylated in cancer 1
chr13_+_113286979 0.337 TFDP1
transcription factor Dp-1
chr12_+_56271259 0.336 PIP4K2C
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
chr8_-_29262240 0.333 NM_057158
DUSP4
dual specificity phosphatase 4
chr19_+_12810258 0.330 NM_014975
MAST1
microtubule associated serine/threonine kinase 1
chr8_-_143692814 0.330 NM_015193
ARC
activity-regulated cytoskeleton-associated protein
chr5_-_132976121 0.330 NM_015082
FSTL4
follistatin-like 4
chr12_+_56271181 0.329 NM_001146258
NM_001146259
NM_001146260
NM_024779
PIP4K2C



phosphatidylinositol-5-phosphate 4-kinase, type II, gamma



chr19_+_4255590 0.329 NM_024333
FSD1
fibronectin type III and SPRY domain containing 1
chr1_+_1062137 0.328 LOC254099
hypothetical protein LOC254099
chr2_+_120820140 0.328 NM_002193
INHBB
inhibin, beta B
chr12_+_120944174 0.328 NM_001024808
NM_020993
BCL7A

B-cell CLL/lymphoma 7A

chr19_+_61846338 0.327 NM_001193628
LOC147670
hypothetical protein LOC147670
chrX_+_152823722 0.327 NM_000054
NM_001146151
AVPR2

arginine vasopressin receptor 2

chr1_-_6218576 0.327 ICMT
isoprenylcysteine carboxyl methyltransferase
chr9_+_139292094 0.327 NM_017723
C9orf167
chromosome 9 open reading frame 167
chr13_-_49597776 0.326 DLEU2
deleted in lymphocytic leukemia 2 (non-protein coding)
chr19_+_40431122 0.326 LSR
lipolysis stimulated lipoprotein receptor
chr2_-_97641489 0.325 ACTR1B
ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
chr1_+_37712661 0.325 NM_025079
ZC3H12A
zinc finger CCCH-type containing 12A
chr16_+_1668284 0.323 HN1L
hematological and neurological expressed 1-like
chr2_-_133144094 0.323 LYPD1
LY6/PLAUR domain containing 1
chr5_+_76150637 0.322 F2RL1
coagulation factor II (thrombin) receptor-like 1
chr2_-_96145614 0.322 NM_000682
ADRA2B
adrenergic, alpha-2B-, receptor
chr1_+_26744893 0.321 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr10_-_71002998 0.320 NM_020999
NEUROG3
neurogenin 3
chr10_-_98935369 0.319 SLIT1
slit homolog 1 (Drosophila)
chr1_+_117950191 0.319 FAM46C
family with sequence similarity 46, member C
chr9_-_138277467 0.317 NM_181701
QSOX2
quiescin Q6 sulfhydryl oxidase 2
chr4_-_2390050 0.317 NM_001172656
NM_001172657
NM_001172658
NM_020972
ZFYVE28



zinc finger, FYVE domain containing 28



chr1_+_117950029 0.316 NM_017709
FAM46C
family with sequence similarity 46, member C
chr6_+_54819527 0.315 NM_001010872
FAM83B
family with sequence similarity 83, member B
chr5_+_31675181 0.315 PDZD2
PDZ domain containing 2
chr4_-_152156314 0.313 NM_006726
LRBA
LPS-responsive vesicle trafficking, beach and anchor containing
chr1_-_11841476 0.312 NM_002521
NPPB
natriuretic peptide B
chr5_-_132976094 0.312 FSTL4
follistatin-like 4
chr19_+_10242763 0.310 ICAM1
intercellular adhesion molecule 1
chr9_+_94987032 0.310 NM_006648
WNK2
WNK lysine deficient protein kinase 2
chr22_-_20419975 0.309 NM_013313
YPEL1
yippee-like 1 (Drosophila)
chr16_+_88280594 0.308 CDK10
cyclin-dependent kinase 10
chr5_+_76150588 0.308 NM_005242
F2RL1
coagulation factor II (thrombin) receptor-like 1
chrX_+_16714452 0.307 NM_001168683
NM_018360
TXLNG

taxilin gamma

chr19_+_18391423 0.307


chr16_+_1763185 0.305 NM_001010865
EME2
essential meiotic endonuclease 1 homolog 2 (S. pombe)
chr3_+_184898234 0.303 NM_018023
YEATS2
YEATS domain containing 2
chr12_-_53059234 0.303 ZNF385A
zinc finger protein 385A

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.11 6.68e-08 GO:0005737 cytoplasm
1.06 1.99e-05 GO:0005622 intracellular
1.06 3.79e-04 GO:0044424 intracellular part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.11 2.56e-05 GO:0005515 protein binding