Motif ID: ZIC1..3.p2

Z-value: 1.174


Transcription factors associated with ZIC1..3.p2:

Gene SymbolEntrez IDGene Name
ZIC1 7545 Zic family member 1 (odd-paired homolog, Drosophila)
ZIC2 7546 Zic family member 2 (odd-paired homolog, Drosophila)
ZIC3 7547 Zic family member 3 (odd-paired homolog, Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ZIC1chr3_+_1486098410.766.1e-04Click!
ZIC2chr13_+_994322580.611.1e-02Click!
ZIC3chrX_+_1364759790.552.6e-02Click!


Activity profile for motif ZIC1..3.p2.

activity profile for motif ZIC1..3.p2


Sorted Z-values histogram for motif ZIC1..3.p2

Sorted Z-values for motif ZIC1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZIC1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_37660568 2.568 NM_003246
 THBS1
thrombospondin 1
chrX_-_107866262 1.106 NM_003604
 IRS4
insulin receptor substrate 4
chr10_-_95350949 1.073 NM_006744
 RBP4
retinol binding protein 4, plasma
chr9_+_111850698 1.070 NM_001004065
NM_001198656
 AKAP2

A kinase (PRKA) anchor protein 2

chr4_-_174687104 1.037 HAND2
heart and neural crest derivatives expressed 2
chr1_+_234372454 1.000 NM_003272
 GPR137B
G protein-coupled receptor 137B
chr19_-_13808101 0.991 LOC284454
hypothetical LOC284454
chr14_+_100362236 0.954 MEG3
maternally expressed 3 (non-protein coding)
chr14_+_100362204 0.951 MEG3
maternally expressed 3 (non-protein coding)
chr14_+_100270222 0.949 DLK1
delta-like 1 homolog (Drosophila)
chr12_+_6517600 0.938


chr12_+_6179736 0.884 NM_001769
 CD9
CD9 molecule
chrX_+_106057984 0.847 CLDN2
claudin 2
chr4_-_174686918 0.822 HAND2
heart and neural crest derivatives expressed 2
chr3_+_171619346 0.810 NM_005602
 CLDN11
claudin 11
chr3_-_88190737 0.805 NM_001008390
NM_003663
 CGGBP1

CGG triplet repeat binding protein 1

chr9_+_99656013 0.764


chr6_+_31479340 0.753 NM_000247
NM_001177519
 MICA

MHC class I polypeptide-related sequence A

chr17_-_25642962 0.733 NM_000386
 BLMH
bleomycin hydrolase
chr1_+_36394044 0.728 MAP7D1
MAP7 domain containing 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 108 entries
enrichment   p-value GO term description
3.22 1.62e-02 GO:0051149 positive regulation of muscle cell differentiation
2.45 8.74e-03 GO:0040013 negative regulation of locomotion
2.09 4.53e-02 GO:0034329 cell junction assembly
2.05 3.47e-02 GO:0034330 cell junction organization
2.03 4.14e-02 GO:0045165 cell fate commitment
2.01 4.17e-03 GO:0048732 gland development
2.00 1.35e-06 GO:0007411 axon guidance
1.91 6.83e-05 GO:0060284 regulation of cell development
1.90 2.92e-07 GO:0048667 cell morphogenesis involved in neuron differentiation
1.89 3.70e-07 GO:0048812 neuron projection morphogenesis
1.89 9.40e-07 GO:0007409 axonogenesis
1.85 5.63e-03 GO:0030334 regulation of cell migration
1.83 5.70e-07 GO:0000904 cell morphogenesis involved in differentiation
1.83 2.38e-03 GO:0051270 regulation of cellular component movement
1.83 8.60e-03 GO:2000145 regulation of cell motility
1.81 4.47e-03 GO:0040012 regulation of locomotion
1.79 1.27e-02 GO:0051960 regulation of nervous system development
1.78 5.95e-06 GO:0031175 neuron projection development
1.78 3.92e-03 GO:0001501 skeletal system development
1.78 4.93e-02 GO:0050767 regulation of neurogenesis

Gene overrepresentation in compartment category:

Showing 1 to 13 of 13 entries
enrichment   p-value GO term description
2.15 2.86e-02 GO:0005925 focal adhesion
2.02 1.11e-02 GO:0034703 cation channel complex
1.85 4.58e-02 GO:0030136 clathrin-coated vesicle
1.75 1.81e-03 GO:0044456 synapse part
1.75 3.36e-02 GO:0034702 ion channel complex
1.71 1.55e-04 GO:0045202 synapse
1.59 7.68e-05 GO:0030054 cell junction
1.36 3.58e-08 GO:0044459 plasma membrane part
1.17 1.68e-03 GO:0071944 cell periphery
1.17 1.77e-03 GO:0005886 plasma membrane
1.06 4.36e-02 GO:0005622 intracellular
1.03 2.58e-02 GO:0044464 cell part
1.03 2.67e-02 GO:0005623 cell

Gene overrepresentation in function category:

Showing 1 to 15 of 15 entries
enrichment   p-value GO term description
2.14 1.50e-03 GO:0022843 voltage-gated cation channel activity
1.88 5.24e-03 GO:0000975 regulatory region DNA binding
1.88 5.24e-03 GO:0001067 regulatory region nucleic acid binding
1.88 5.24e-03 GO:0044212 transcription regulatory region DNA binding
1.88 8.06e-03 GO:0010843 promoter binding
1.70 2.36e-02 GO:0005261 cation channel activity
1.67 1.39e-02 GO:0016564 transcription repressor activity
1.66 1.16e-02 GO:0016563 transcription activator activity
1.63 2.05e-06 GO:0043565 sequence-specific DNA binding
1.58 6.48e-03 GO:0019904 protein domain specific binding
1.51 1.31e-06 GO:0030528 transcription regulator activity
1.48 1.90e-05 GO:0001071 nucleic acid binding transcription factor activity
1.48 1.90e-05 GO:0003700 sequence-specific DNA binding transcription factor activity
1.45 4.55e-02 GO:0008324 cation transmembrane transporter activity
1.10 3.67e-02 GO:0005515 protein binding