Motif ID: ADNP_IRX_SIX_ZHX.p2

Z-value: 1.349


Transcription factors associated with ADNP_IRX_SIX_ZHX.p2:

Gene SymbolEntrez IDGene Name
ADNP 23394 activity-dependent neuroprotector homeobox
IRX4 50805 iroquois homeobox 4
IRX5 10265 iroquois homeobox 5
SIX2 10736 SIX homeobox 2
SIX5 147912 SIX homeobox 5
ZHX1 11244 zinc fingers and homeoboxes 1
ZHX2 22882 zinc fingers and homeoboxes 2
ZHX3 23051 zinc fingers and homeoboxes 3



Activity profile for motif ADNP_IRX_SIX_ZHX.p2.

activity profile for motif ADNP_IRX_SIX_ZHX.p2


Sorted Z-values histogram for motif ADNP_IRX_SIX_ZHX.p2

Sorted Z-values for motif ADNP_IRX_SIX_ZHX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ADNP_IRX_SIX_ZHX.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_153698930 2.367 HMGN1P37
high-mobility group nucleosome binding domain 1 pseudogene 37
chr8_-_86477585 1.748 NM_001128829
NM_001128830
NM_001128831
NM_001738
CA1



carbonic anhydrase I



chr10_+_5126556 1.665 NM_003739
AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr10_+_5126589 1.621 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr10_+_5126613 1.529 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr7_-_13992351 1.465 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr1_-_93030538 1.428 NM_005665
EVI5
ecotropic viral integration site 5
chr1_+_166516901 1.412 NM_005149
TBX19
T-box 19
chr9_-_99740243 1.388 NM_197978
HEMGN
hemogen
chr6_-_49820030 1.388 NM_001190986
NM_006061
CRISP3

cysteine-rich secretory protein 3

chr1_+_556968 1.288


chr2_-_192420168 1.260 NM_004657
SDPR
serum deprivation response
chr4_-_79322295 1.226


chr12_+_52697160 1.121 HOXC5
HOXC6
homeobox C5
homeobox C6
chr22_-_34566367 1.092 NM_001031695
NM_001082576
NM_001082577
NM_014309
RBFOX2



RNA binding protein, fox-1 homolog (C. elegans) 2



chr6_+_112775224 1.035 NM_001013734
RFPL4B
ret finger protein-like 4B
chr11_+_113672378 1.030 NNMT
nicotinamide N-methyltransferase
chr11_+_113671744 1.029 NM_006169
NNMT
nicotinamide N-methyltransferase
chr11_+_113672407 1.021 NNMT
nicotinamide N-methyltransferase
chr3_-_143230124 1.015 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr6_+_105511615 1.009 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr17_-_44037332 0.912 NM_018952
HOXB6
homeobox B6
chr12_+_52696908 0.901 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr7_-_25234582 0.898 NM_022150
NPVF
neuropeptide VF precursor
chr1_-_156923111 0.894 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr12_+_56802 0.893 NM_015232
IQSEC3
IQ motif and Sec7 domain 3
chr11_-_33870411 0.883 NM_005574
LMO2
LIM domain only 2 (rhombotin-like 1)
chr2_+_220087135 0.881 NM_018674
NM_182847
ACCN4

amiloride-sensitive cation channel 4, pituitary

chr7_-_107667728 0.879 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr2_+_157822355 0.878 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr7_-_16471817 0.874 NM_015464
SOSTDC1
sclerostin domain containing 1
chr12_+_52680143 0.853 NM_006897
HOXC9
homeobox C9
chr11_+_123600553 0.852 NM_001007249
OR8G2
olfactory receptor, family 8, subfamily G, member 2
chr2_-_192419896 0.847 SDPR
serum deprivation response
chr12_-_69434330 0.831 PTPRR
protein tyrosine phosphatase, receptor type, R
chrX_+_79562601 0.822 NM_152630
FAM46D
family with sequence similarity 46, member D
chr7_-_13996166 0.810 NM_001163147
NM_004956
ETV1

ets variant 1

chr3_-_71625318 0.801 FOXP1
forkhead box P1
chr7_+_129771865 0.789 NM_001127441
NM_001127442
NM_080385
CPA5


carboxypeptidase A5


chr5_-_88235624 0.781 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr7_-_92693716 0.776 NM_001039372
HEPACAM2
HEPACAM family member 2
chr5_+_140751666 0.757 NM_014004
NM_032088
PCDHGA8

protocadherin gamma subfamily A, 8

chr21_+_24722913 0.756 FLJ42200
FLJ42200 protein
chr9_+_102380156 0.748 NM_001018116
MURC
muscle-related coiled-coil protein
chr10_+_70745615 0.721 NM_033496
HK1
hexokinase 1
chr7_-_100262971 0.712 NM_004444
EPHB4
EPH receptor B4
chr2_-_200030412 0.708 SATB2
SATB homeobox 2
chr4_-_91979113 0.700 NM_183049
TMSL3
thymosin-like 3
chr1_+_557269 0.700


chr4_-_74307637 0.695 ANKRD17
ankyrin repeat domain 17
chr21_-_14840506 0.693 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr7_-_112514990 0.687 GPR85
G protein-coupled receptor 85
chr6_-_2696152 0.686 NM_001012418
MYLK4
myosin light chain kinase family, member 4
chr9_+_134843918 0.680 NM_001135031
NM_004188
GFI1B

growth factor independent 1B transcription repressor

chrX_-_13744933 0.674 GPM6B
glycoprotein M6B
chr9_+_129900637 0.665 NM_052901
NM_001006643
SLC25A25

solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25

chr16_+_68238460 0.662 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr1_+_61642287 0.659 NFIA
nuclear factor I/A
chr6_-_25982418 0.655 NM_001098486
NM_006632
SLC17A3

solute carrier family 17 (sodium phosphate), member 3

chr4_-_72868598 0.655 NM_000583
GC
group-specific component (vitamin D binding protein)
chr7_+_106897737 0.650 NM_005295
GPR22
G protein-coupled receptor 22
chr18_-_29273979 0.649 NM_001105528
C18orf34
chromosome 18 open reading frame 34
chr3_-_197726587 0.640 NM_001077657
C3orf43
chromosome 3 open reading frame 43
chr6_-_10523424 0.638 NM_003220
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr22_-_34566210 0.628 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr7_-_142369519 0.620 KEL
Kell blood group, metallo-endopeptidase
chr2_+_178893216 0.610 NM_145739
OSBPL6
oxysterol binding protein-like 6
chrX_-_119593646 0.609 NM_003588
CUL4B
cullin 4B
chr9_+_129900590 0.607 SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr22_-_34566276 0.604 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr1_+_198263352 0.602 NM_003822
NM_205860
NR5A2

nuclear receptor subfamily 5, group A, member 2

chr1_-_180822686 0.598 NM_021133
RNASEL
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
chr16_+_33169015 0.598 NM_016212
TP53TG3
TP53 target 3
chr7_-_135263737 0.594 MTPN
LUZP6
myotrophin
leucine zipper protein 6
chr15_-_74091817 0.591 NM_138573
NRG4
neuregulin 4
chr1_+_74473672 0.590 NM_015978
TNNI3K
TNNI3 interacting kinase
chr3_-_147696411 0.590 NM_020359
PLSCR2
phospholipid scramblase 2
chr7_+_129634935 0.589 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr5_-_132228375 0.585 NM_005260
GDF9
growth differentiation factor 9
chr1_+_203503214 0.585 TMCC2
transmembrane and coiled-coil domain family 2
chr2_+_158559936 0.564 NM_001135098
UPP2
uridine phosphorylase 2
chr21_-_31995972 0.557 SCAF4
SR-related CTD-associated factor 4
chr1_+_115373937 0.553 NM_000549
TSHB
thyroid stimulating hormone, beta
chr7_-_112515068 0.546 NM_001146265
NM_018970
GPR85

G protein-coupled receptor 85

chr16_+_33112480 0.535 NM_016212
TP53TG3
TP53 target 3
chr7_-_13995811 0.531 ETV1
ets variant 1
chr2_-_87906400 0.529 NM_001078170
RGPD2
RANBP2-like and GRIP domain containing 2
chr21_+_37713076 0.522 NM_130436
DYRK1A
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
chr14_+_67238355 0.520 NM_152443
RDH12
retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
chr7_-_87180499 0.516 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr17_-_64462976 0.510 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr5_+_140698537 0.507 NM_018915
NM_032009
PCDHGA2

protocadherin gamma subfamily A, 2

chr1_+_84646621 0.500 NM_058248
DNASE2B
deoxyribonuclease II beta
chr9_-_205892 0.500 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr9_+_74956614 0.498 ANXA1
annexin A1
chr1_+_22107137 0.498 RPL21
ribosomal protein L21
chr1_+_152560179 0.493 NM_080429
AQP10
aquaporin 10
chr3_-_69254226 0.487 NM_198271
LMOD3
leiomodin 3 (fetal)
chr2_-_121875610 0.482 CLASP1
cytoplasmic linker associated protein 1
chr7_-_75794919 0.481 YWHAG
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
chr5_-_134291882 0.480


chr16_+_7322751 0.477 NM_145891
NM_145892
NM_145893
RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr20_+_186376 0.477 NM_207469
DEFB132
defensin, beta 132
chr12_-_10453409 0.474 NM_013431
KLRC4-KLRK1
KLRC4
KLRC4-KLRK1 read-through transcript
killer cell lectin-like receptor subfamily C, member 4
chr11_+_120478584 0.473 NM_005422
TECTA
tectorin alpha
chr10_+_89257569 0.473 NM_001178118
MINPP1
multiple inositol-polyphosphate phosphatase 1
chr1_-_205272619 0.471 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr1_-_42738535 0.468 TMSB4XP1
thymosin beta 4, X-linked pseudogene 1
chrX_-_18600108 0.468 NM_000330
RS1
retinoschisin 1
chr12_-_69434650 0.467 PTPRR
protein tyrosine phosphatase, receptor type, R
chr20_-_604822 0.466 NM_033129
SCRT2
scratch homolog 2, zinc finger protein (Drosophila)
chr2_-_144994038 0.464 ZEB2
zinc finger E-box binding homeobox 2
chr12_+_54172413 0.462 NM_001005519
OR6C68
olfactory receptor, family 6, subfamily C, member 68
chr2_+_102401580 0.460 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr12_-_51476047 0.459 NM_057088
KRT3
keratin 3
chr17_-_74361620 0.457 TIMP2
TIMP metallopeptidase inhibitor 2
chr4_+_22608252 0.454


chr2_-_99412694 0.454 REV1
REV1 homolog (S. cerevisiae)
chr10_+_4995685 0.452 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr17_-_30909219 0.451 NM_001129820
SLFN14
schlafen family member 14
chr19_-_21438525 0.450


chr11_+_93940121 0.450 NM_152431
PIWIL4
piwi-like 4 (Drosophila)
chr10_+_4995453 0.449 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr12_-_69434598 0.449 NM_130846
PTPRR
protein tyrosine phosphatase, receptor type, R
chr7_-_112515035 0.448 GPR85
G protein-coupled receptor 85
chr3_-_57209319 0.445 NM_003865
HESX1
HESX homeobox 1
chr3_+_35697432 0.445 NM_198399
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr3_-_168674502 0.444 NM_006217
SERPINI2
serpin peptidase inhibitor, clade I (pancpin), member 2
chr4_+_74825138 0.443 NM_000584
IL8
interleukin 8
chr5_-_134290789 0.443


chr3_-_71262426 0.442 FOXP1
forkhead box P1
chr17_-_51155073 0.440 NM_018286
TMEM100
transmembrane protein 100
chr16_-_47873183 0.439 NM_004352
CBLN1
cerebellin 1 precursor
chr11_-_16454493 0.437 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chr21_-_35343428 0.437 RUNX1
runt-related transcription factor 1
chr2_+_33592445 0.437 NM_015376
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr21_-_35343456 0.436 NM_001754
RUNX1
runt-related transcription factor 1
chr1_-_160613203 0.435 NM_182581
C1orf111
chromosome 1 open reading frame 111
chr13_+_52114565 0.432 HNRNPA1L2
heterogeneous nuclear ribonucleoprotein A1-like 2
chr10_+_49279647 0.432 NM_002750
NM_139046
NM_139047
NM_139049
MAPK8



mitogen-activated protein kinase 8



chrX_-_137649180 0.429 NM_033642
FGF13
fibroblast growth factor 13
chr6_+_45404031 0.429 NM_001015051
NM_001024630
RUNX2

runt-related transcription factor 2

chr18_-_55136673 0.428 NM_181654
CPLX4
complexin 4
chr22_+_21006814 0.427


chr1_+_109057078 0.419 NM_001144937
FNDC7
fibronectin type III domain containing 7
chr19_+_61624 0.418 NM_001005240
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr7_+_113853790 0.418 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr2_-_99238001 0.415 NM_175735
LYG2
lysozyme G-like 2
chr14_-_80934523 0.412 NM_033104
STON2
stonin 2
chr3_+_129682434 0.411


chr2_+_166137091 0.410 NM_024969
CSRNP3
cysteine-serine-rich nuclear protein 3
chr10_+_70517823 0.410 NM_002727
SRGN
serglycin
chr3_-_196792059 0.409 APOD
apolipoprotein D
chr2_+_171316462 0.406 EIF2S2
eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
chr21_-_35343448 0.405 RUNX1
runt-related transcription factor 1
chrX_-_15243647 0.404 NM_080873
ASB11
ankyrin repeat and SOCS box containing 11
chr5_-_1935764 0.404 NM_016358
IRX4
iroquois homeobox 4
chr3_-_71262405 0.400 FOXP1
forkhead box P1
chr5_-_75044001 0.400 NM_152408
POC5
POC5 centriolar protein homolog (Chlamydomonas)
chr4_-_54152480 0.399 NM_001126328
LNX1
ligand of numb-protein X 1
chr21_-_35343331 0.398 RUNX1
runt-related transcription factor 1
chrX_-_102828238 0.398 NM_001142418
NM_001142423
NM_001142424
NM_001142425
NM_001142426
NM_001142429
NM_001142430
NM_012286
MORF4L2







mortality factor 4 like 2







chr11_-_64484184 0.397 NM_001037225
C11orf85
chromosome 11 open reading frame 85
chr4_+_41395493 0.396 LIMCH1
LIM and calponin homology domains 1
chr6_-_28429950 0.396 NM_145909
ZNF323
zinc finger protein 323
chr9_-_74757735 0.393 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr10_+_70517863 0.392 SRGN
serglycin
chr11_-_66976775 0.392 NM_206997
GPR152
G protein-coupled receptor 152
chr1_-_201321999 0.386 NM_002479
MYOG
myogenin (myogenic factor 4)
chr9_+_109131814 0.386 RAD23B
RAD23 homolog B (S. cerevisiae)
chr3_+_35658852 0.385 NM_016300
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr8_+_92330691 0.384 NM_052832
NM_134266
SLC26A7

solute carrier family 26, member 7

chr4_-_977163 0.381 NM_022042
NM_134425
NM_213613
SLC26A1


solute carrier family 26 (sulfate transporter), member 1


chr3_+_25445071 0.381 RARB
retinoic acid receptor, beta
chr2_+_108571177 0.379 NM_004987
LIMS1
LIM and senescent cell antigen-like domains 1
chr6_+_7524691 0.378 DSP
desmoplakin
chr6_-_38778860 0.378 GLO1
glyoxalase I
chr7_+_80113903 0.378 CD36
CD36 molecule (thrombospondin receptor)
chr1_-_120189301 0.377 NM_001047980
NBPF7
neuroblastoma breakpoint family, member 7
chr9_-_122679283 0.376 PHF19
PHD finger protein 19
chr3_-_25658829 0.374 TOP2B
topoisomerase (DNA) II beta 180kDa
chr12_-_51200347 0.374 NM_000424
KRT5
keratin 5
chr9_+_95886625 0.373 PTPDC1
protein tyrosine phosphatase domain containing 1
chr17_-_16038607 0.373 NM_001190438
NM_001190440
NCOR1

nuclear receptor corepressor 1

chr4_-_54152385 0.372 LNX1
ligand of numb-protein X 1
chr6_-_74284522 0.371 EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr5_+_42792676 0.370 NM_001134848
CCDC152
coiled-coil domain containing 152
chr6_+_153060722 0.369 NM_025107
MYCT1
myc target 1
chr5_+_139485703 0.368 NM_001007189
C5orf53
chromosome 5 open reading frame 53
chr22_-_34564611 0.367 RPL41P5
ribosomal protein L41 pseudogene 5
chr7_+_156128431 0.367 NM_001184997
RNF32
ring finger protein 32
chr6_+_49575629 0.367 NM_001010904
GLYATL3
glycine-N-acyltransferase-like 3
chr21_-_26175068 0.365 APP
amyloid beta (A4) precursor protein
chr15_+_71522551 0.364 NM_001042367
C15orf60
chromosome 15 open reading frame 60
chr17_-_15495534 0.364 TRIM16
tripartite motif containing 16
chr4_+_71492581 0.363 NM_016519
AMBN
ameloblastin (enamel matrix protein)
chr12_+_29267863 0.361 NM_018099
FAR2
fatty acyl CoA reductase 2
chrX_+_44588192 0.361 NM_022076
DUSP21
dual specificity phosphatase 21
chr6_+_155579788 0.359 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chrX_-_55074125 0.359 NM_000032
NM_001037967
NM_001037968
ALAS2


aminolevulinate, delta-, synthase 2



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.72 1.40e-18 GO:0007606 sensory perception of chemical stimulus
2.72 2.13e-16 GO:0007608 sensory perception of smell
2.12 5.06e-15 GO:0007600 sensory perception
1.66 4.48e-09 GO:0050877 neurological system process
1.56 2.75e-08 GO:0003008 system process
1.27 7.84e-08 GO:0032501 multicellular organismal process
1.15 3.39e-02 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.19 5.34e-03 GO:0071944 cell periphery
1.19 1.12e-02 GO:0005886 plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.79 2.03e-17 GO:0004984 olfactory receptor activity
2.02 1.85e-13 GO:0004930 G-protein coupled receptor activity
1.64 1.08e-08 GO:0004888 transmembrane receptor activity
1.46 4.08e-06 GO:0004872 receptor activity
1.36 2.63e-04 GO:0004871 signal transducer activity
1.36 2.63e-04 GO:0060089 molecular transducer activity