Mean activities

Top 10 and bottom 10 mean activities.

Mean activities

Mean activities sorted by motif Z-value.

Mean activities

Sorted mean activities for every motif.

Motif nameMean activityZ-ValueAssociated genesLogo
STAT5{A,B}.p2 0.600 1.715 STAT5B
STAT5A (MGF)
RXRG_dimer.p3 0.348 0.893 NR1H2 (NER, NER-I, RIP15, LXR-b)
RXRA (NR2B1)
PPARG (PPARG1, PPARG2, NR1C3, PPARgamma)
PPARA (hPPAR, NR1C1)
RXRB (NR2B2, H-2RIIBP, RCoR-1)
RXRG (NR2B3)
PRDM1.p3 0.334 0.851 PRDM1 (PRDI-BF1)
ZNF143.p2 0.305 3.805 ZNF143 (SBF, pHZ-1, STAF)
IRF1,2,7.p3 0.280 1.418 IRF1 (MAR, IRF-1)
IRF2 (IRF-2, DKFZp686F0244)
IRF7 (IRF7A, IRF-7H)
EHF.p2 0.250 2.679 EHF
CREB1.p2 0.244 1.630 CREB1
CTCF.p2 0.241 1.317 CTCF
ELK1,4_GABP{A,B1}.p3 0.237 3.291 GABPA (E4TF1A, NFT2, NRF2, E4TF1-60, NRF2A)
GABPB1 (E4TF1-47, GABPB)
ELK4 (SAP1)
ELK1
FOX{D1,D2}.p2 0.219 1.060 FOXD2 (FREAC9)
FOXD1 (FREAC4)
NRF1.p2 0.216 3.899 NRF1 (EWG, ALPHA-PAL)
FOXN1.p2 0.201 1.097 FOXN1 (FKHL20)
XBP1.p3 0.184 0.582 XBP1
E2F1..5.p2 0.166 1.171 E2F4 (E2F-4)
E2F5
E2F2 (E2F-2)
E2F1 (RBP3)
E2F3
NFY{A,B,C}.p2 0.165 2.034 NFYC (CBF-C)
NFYB (CBF-A, HAP3)
NFYA (HAP2, CBF-B)
NFIL3.p2 0.156 0.386 NFIL3 (E4BP4, NFIL3A, NF-IL3A)
SREBF1,2.p2 0.149 0.725 SREBF1 (SREBP1, bHLHd1)
SREBF2 (SREBP2, bHLHd2)
GFI1.p2 0.144 1.336 GFI1
ATF4.p2 0.133 0.811 ATF4 (TAXREB67, CREB-2)
FOS_FOS{B,L1}_JUN{B,D}.p2 0.129 0.669 FOS (c-fos, AP-1)
JUNB
FOSL1 (fra-1)
JUND (AP-1)
FOSB (G0S3, GOSB, GOS3, AP-1, MGC42291, DKFZp686C0818)
PAX2.p2 0.125 1.194 PAX2
RFX1..5_RFXANK_RFXAP.p2 0.119 0.867 RFX1 (EF-C)
RFXAP
RFX5
RFXANK (BLS, RFX-B, ANKRA1, F14150_1, MGC138628)
RFX4
RFX3
RFX2 (FLJ14226)
ATF5_CREB3.p2 0.119 1.026 ATF5
CREB3 (LZIP, Luman)
HBP1_HMGB_SSRP1_UBTF.p2 0.118 0.874 HMGB2
HMGB3 (HMG2A, MGC90319)
SSRP1 (FACT80)
UBTF (UBF, NOR-90)
HBP1
NFIX.p2 0.108 0.471 NFIX (NF1A)
ELF1,2,4.p2 0.098 1.651 ELF2 (EU32, NERF, NERF-2, NERF-1A, NERF-1B)
ELF1
ELF4 (MEF, ELFR)
YY1.p2 0.091 2.113 YY1 (NF-E1, DELTA, UCRBP, YIN-YANG-1, INO80S)
NFKB1_REL_RELA.p2 0.079 0.627 RELA (p65)
REL (I-Rel)
NFKB1 (KBF1, p105)
RBPJ.p2 0.077 0.392 RBPJ (SUH, IGKJRB, RBPJK, KBF2, RBP-J, CBF1)
ESRRA.p2 0.076 0.367 ESRRA (ERR1, ERRalpha, NR3B1, ERRa)
SOX{8,9,10}.p2 0.076 0.490 SOX9 (SRA1)
SOX8
SOX10 (DOM, WS4, WS2E)
bHLH_family.p2 0.071 0.786 ARNTL (MOP3, JAP3, BMAL1, PASD3, bHLHe5)
MITF (WS2A, MI, bHLHe32)
MXI1 (MXD2, MAD2, MXI, bHLHc11)
TFE3 (TFEA, bHLHe33)
CLOCK (KIAA0334, KAT13D, bHLHe8)
OLIG2 (RACK17, OLIGO2, bHLHe19)
MXD4 (MAD4, MSTP149, MST149, bHLHc12)
HEY2 (bHLHb32)
HEY1 (HESR-1, CHF2, HESR1, HRT-1, CHF-2, HERP2, BHLHb31)
HEYL (bHLHb33)
MLXIPL (WS-bHLH, MIO, CHREBP, MONDOB)
HES6 (bHLHc23)
MXD3 (MAD3, bHLHc13)
ARNTL2 (BMAL2, MOP9, CLIF, PASD9, bHLHe6)
ID1 (dJ857M17.1.2, bHLHb24)
MNT (ROX, MXD6, MAD6, bHLHd3)
OLIG1 (BHLHB6, bHLHe21)
NPAS2 (MOP4, PASD4, bHLHe9)
SP1.p2 0.057 2.260 SP1
EP300.p2 0.056 0.641 EP300 (p300, KAT3B)
FOXD3.p2 0.055 0.597 FOXD3 (Genesis, HFH2)
HES1.p2 0.055 0.680 HES1 (FLJ20408, HES-1, Hes1, bHLHb39)
MYB.p2 0.054 0.484 MYB (c-myb)
MAFB.p2 0.045 0.814 MAFB
IKZF1.p2 0.044 0.270 IKZF1 (hIk-1, LyF-1, Hs.54452, IKAROS)
PBX1.p2 0.041 0.145 PBX1
NKX3-2.p2 0.041 0.380 NKX3-2 (NKX3B, NKX3.2)
NHLH1,2.p2 0.039 0.675 NHLH1 (NSCL, NSCL1, bHLHa35)
NHLH2 (NSCL2, bHLHa34)
AHR_ARNT_ARNT2.p2 0.038 0.558 ARNT (HIF-1beta, bHLHe2)
AHR
ARNT2 (KIAA0307, bHLHe1)
BPTF.p2 0.036 0.652 BPTF (FAC1, NURF301)
PAX5.p2 0.036 1.053 PAX5 (BSAP)
EWSR1-FLI1.p2 0.034 0.121 FLI1 (EWSR2, SIC-1)
EWSR1 (EWS, K984G1.4)
PRRX1,2.p2 0.034 0.537 PRRX2 (PRX2, PMX2)
PRRX1 (PHOX1)
ZBTB6.p2 0.033 0.350 ZBTB6 (ZID)
KLF4.p3 0.031 1.055 KLF4 (EZF, GKLF)
SOX17.p2 0.031 0.242 SOX17
HMX1.p2 0.029 0.199 HMX1 (H6, NKX5-3)
NFE2L2.p2 0.028 0.092 NFE2L2 (NRF2)
ESR1.p2 0.027 0.191 ESR1 (NR3A1, Era)
TFDP1.p2 0.026 1.117 TFDP1 (Dp-1, DRTF1, DP1)
TLX2.p2 0.022 0.158 TLX2 (Enx, Tlx2, NCX)
CUX2.p2 0.022 0.030 CUX2 (KIAA0293, CDP2)
SPI1.p2 0.019 0.419 SPI1 (PU.1, SPI-A, OF, SFPI1, SPI-1)
HIF1A.p2 0.017 0.153 HIF1A (MOP1, HIF-1alpha, PASD8, HIF1)
ZNF384.p2 0.017 0.158 ZNF384 (CAGH1A, CIZ, NMP4, NP)
TFAP2{A,C}.p2 0.015 0.727 TFAP2C (AP2-GAMMA, ERF1, TFAP2G, hAP-2g)
TFAP2A (AP-2)
SPIB.p2 0.013 0.224 SPIB (SPI-B)
FOXO1,3,4.p2 0.010 0.054 FOXO1 (FKH1)
FOXO4 (AFX1)
FOXO3 (AF6q21, FOXO2)
SPZ1.p2 0.009 0.128 SPZ1 (NYD-TSP1, FLJ25709)
FOX{I1,J2}.p2 0.009 0.078 FOXI1 (FREAC6)
FOXJ2 (FHX)
TFAP2B.p2 0.007 0.252 TFAP2B (AP2-B)
ZEB1.p2 0.004 0.052 ZEB1 (BZP, ZEB, AREB6, NIL-2-A, Zfhep, Zfhx1a)
POU2F1..3.p2 0.001 0.006 POU2F2 (OCT2)
POU2F1 (OCT1)
POU2F3 (OCT11, PLA-1, Skn-1a, Epoc-1)
TP53.p2 -0.001 -0.002 TP53 (p53, LFS1)
NKX6-1,2.p2 -0.001 -0.003 NKX6-1 (Nkx6.1)
NKX6-2 (NKX6B, GTX, NKX6.1)
HIC1.p2 -0.002 -0.052 HIC1 (ZBTB29)
STAT2,4,6.p2 -0.004 -0.044 STAT2 (STAT113)
STAT4
STAT6 (D12S1644, IL-4-STAT)
HOX{A6,A7,B6,B7}.p2 -0.006 -0.130 HOXB6
HOXA7
HOXB7
HOXA6
ZIC1..3.p2 -0.007 -0.049 ZIC1 (ZIC, ZNF201)
ZIC2 (HPE5)
ZIC3 (HTX, ZNF203)
SRY.p2 -0.009 -0.065 SRY (TDF)
ZFP161.p2 -0.009 -0.186 ZFP161 (ZNF478, ZBTB14)
MZF1.p2 -0.011 -0.357 MZF1 (MZF1B, ZSCAN6, MZF-1, Zfp98)
TFAP4.p2 -0.011 -0.110 TFAP4 (AP-4)
RXR{A,B,G}.p2 -0.013 -0.124 RXRA (NR2B1)
RXRB (NR2B2, H-2RIIBP, RCoR-1)
RXRG (NR2B3)
PATZ1.p2 -0.013 -0.416 PATZ1 (MAZR, dJ400N23, ZBTB19, ZSG, RIAZ, PATZ)
MTF1.p2 -0.013 -0.247 MTF1
ARNT_ARNT2_BHLHB2_MAX_MYC_USF1.p2 -0.015 -0.097 ARNT (HIF-1beta, bHLHe2)
MAX (bHLHd4)
MYC (c-Myc, bHLHe39)
USF1 (UEF, MLTFI, bHLHb11)
BHLHB2 (DEC1, bHLHe40)
ARNT2 (KIAA0307, bHLHe1)
GTF2I.p2 -0.017 -0.483 GTF2I (TFII-I, BAP-135, SPIN, BTKAP1, DIWS, IB291)
EGR1..3.p2 -0.019 -0.390 EGR3 (PILOT)
EGR1 (TIS8, G0S30, NGFI-A, KROX-24, ZIF-268, AT225, ZNF225)
EGR2
PAX4.p2 -0.021 -0.085 PAX4
TEAD1.p2 -0.023 -0.097 TEAD1 (TEF-1)
TEAD2 (ETF, TEF4, TEF-4, TEAD-2)
TEAD3 (TEF5, TEAD5, TEF-5, DTEF-1, ETFR-1, TEAD-3)
TEAD4 (TEF3, RTEF1, TEF-3, EFTR-2, TEFR-1, TCF13L1, hRTEF-1B)
ATF6.p2 -0.029 -0.192 ATF6 (ATF6A)
MAZ.p2 -0.033 -1.181 MAZ (ZF87, Pur-1, Zif87, ZNF801)
NFE2.p2 -0.037 -0.132 NFE2 (NF-E2)
CDX1,2,4.p2 -0.038 -0.300 CDX1
CDX2
CDX4
HLF.p2 -0.038 -0.115 HLF (MGC33822)
ZNF148.p2 -0.038 -0.618 ZNF148 (BERF-1, ZBP-89, BFCOL1, HT-BETA, ZFP148, pHZ-52)
POU5F1.p2 -0.038 -0.288 POU5F1 (OCT3, Oct4, MGC22487)
TCF4_dimer.p2 -0.039 -0.608 TCF4 (E2-2, ITF2, PTHS, SEF2, SEF2-1, SEF2-1A, SEF2-1B, bHLHb19, MGC149723, MGC149724)
JUN.p2 -0.041 -0.320 JUN (c-Jun, AP-1)
JUND (AP-1)
JUNB
IKZF2.p2 -0.041 -0.343 IKZF2 (Helios)
FEV.p2 -0.045 -0.623 FEV (PET-1, HSRNAFEV)
TBX4,5.p2 -0.046 -0.311 TBX5
TBX4
NFATC1..3.p2 -0.050 -0.397 NFATC3 (NFAT4, NFATX)
NFATC2 (NF-ATP, NFATp, NFAT1)
NFATC1 (NF-ATC, NFATc, NFAT2)
FOXQ1.p2 -0.050 -0.249 FOXQ1 (HFH1)
DMAP1_NCOR{1,2}_SMARC.p2 -0.055 -0.237 SMARCA1 (SNF2LB, NURF140, ISWI, SWI)
SMARCC2 (BAF170, Rsc8, CRACC2)
SMARCA5 (hSNF2H, hISWI, ISWI)
NCOR1 (N-CoR, hCIT529I10, TRAC1, hN-CoR, KIAA1047, MGC104216)
NCOR2 (SMRT, SMRTE, TRAC-1, CTG26, TNRC14)
DMAP1 (DNMAP1, FLJ11543, KIAA1425, DNMTAP1, EAF2, SWC4)
LMO2.p2 -0.055 -0.574 LMO2 (TTG2, RHOM2, RBTN2)
EBF1.p2 -0.056 -0.494 EBF1 (OLF1)
BACH2.p2 -0.057 -0.183 BACH2
GLI1..3.p2 -0.057 -0.400 GLI1
GLI2 (THP2, HPE9, THP1)
GLI3 (PAP-A, PAPA, PAPA1, PAPB, ACLS, PPDIV)
SNAI1..3.p2 -0.061 -0.941 SNAI2 (SLUGH1)
SNAI1 (SNA, SLUGH2, SNAH)
SNAI3 (SMUC, Zfp293)
TFEB.p2 -0.062 -0.429 TFEB
GZF1.p2 -0.062 -0.050 GZF1 (dJ322G13.2, ZBTB23)
MYBL2.p2 -0.064 -0.219 MYBL2 (BMYB, B-MYB)
NKX2-2,8.p2 -0.065 -0.270 NKX2-2 (NKX2.2)
NKX2-8 (NKX2.8, Nkx2-9)
SRF.p3 -0.065 -0.170 SRF (MCM1)
ATF2.p2 -0.065 -0.350 ATF2 (TREB7, CRE-BP1, HB16)
NKX2-3_NKX2-5.p2 -0.065 -0.290 NKX2-5 (CSX1, NKX2.5, NKX4-1)
NKX2-3 (NKX2.3, CSX3, NKX4-3)
ZBTB16.p2 -0.065 -0.472 ZBTB16 (PLZF)
MYFfamily.p2 -0.067 -1.322 MYOD1 (PUM, MYOD, bHLHc1)
MYF6 (MRF4, bHLHc4)
MYF5 (bHLHc2)
MYOG (bHLHc3)
SOX2.p2 -0.068 -0.512 SOX2
ADNP_IRX_SIX_ZHX.p2 -0.070 -0.481 SIX5
ZHX1
IRX4
ADNP (KIAA0784, ADNP1)
ZHX3 (KIAA0395)
ZHX2 (KIAA0854)
IRX5 (IRX-2a)
SIX2
LEF1_TCF7_TCF7L1,2.p2 -0.072 -0.366 TCF7 (TCF-1)
TCF7L2 (TCF-4)
LEF1 (TCF1ALPHA)
TCF7L1
TFCP2.p2 -0.073 -1.055 TFCP2 (CP2, LSF, LBP-1C, TFCP2C)
FOX{F1,F2,J1}.p2 -0.074 -0.273 FOXF2 (FREAC2)
FOXJ1 (HFH-4, HFH4)
FOXF1 (FREAC1)
NANOG.p2 -0.079 -0.242 NANOG (FLJ12581, FLJ40451)
MEF2{A,B,C,D}.p2 -0.087 -0.530 MEF2A (RSRFC4, RSRFC9)
MEF2C
MEF2D
MEF2BNB-MEF2B (MEF2B, LOC729991-MEF2B)
MEF2B (RSRFR2, FLJ32648)
STAT1,3.p3 -0.091 -0.186 STAT1 (STAT91, ISGF-3)
STAT3 (APRF)
GATA1..3.p2 -0.097 -1.537 GATA1 (ERYF1, NFE1)
GATA2 (NFE1B)
GATA3 (HDR)
TGIF1.p2 -0.098 -0.549 TGIF1
SOX5.p2 -0.098 -0.565 SOX5 (L-SOX5, MGC35153)
GTF2A1,2.p2 -0.101 -0.579 GTF2A1 (TFIIA)
GTF2A2 (TFIIA, HsT18745)
HMGA1,2.p2 -0.103 -1.008 HMGA1
HMGA2 (BABL, LIPO)
MYOD1.p2 -0.104 -1.038 MYOD1 (PUM, MYOD, bHLHc1)
RREB1.p2 -0.110 -2.420 RREB1 (HNT)
ETS1,2.p2 -0.118 -1.307 ETS2
ETS1 (FLJ10768, ETS-1)
LHX3,4.p2 -0.120 -0.499 LHX3
LHX4 (Gsh4)
NFE2L1.p2 -0.120 -1.714 NFE2L1 (NRF1, LCR-F1, FLJ00380, TCF11)
NR6A1.p2 -0.124 -0.190 NR6A1 (GCNF1, RTR)
KLF12.p2 -0.130 -1.979 KLF12 (AP-2rep, HSPC122, AP2REP)
NR5A1,2.p2 -0.131 -1.165 NR5A1 (FTZ1, SF-1, ELP, AD4BP)
NR5A2 (FTZ-F1beta, hB1F, LRH-1, FTZ-F1, hB1F-2, B1F2)
POU3F1..4.p2 -0.132 -0.368 POU3F1 (OCT6, SCIP)
POU3F3 (BRN1, OTF8)
POU3F2 (POUF3, BRN2, OCT7)
POU3F4 (BRN4, OTF9)
CRX.p2 -0.135 -0.694 CRX (CRD, LCA7, OTX3)
ZNF423.p2 -0.142 -0.817 ZNF423 (KIAA0760, OAZ, Roaz, Ebfaz, Zfp104)
VSX1,2.p2 -0.145 -0.179 VSX2 (RET1)
VSX1 (PPD)
PITX1..3.p2 -0.146 -1.670 PITX2 (IGDS, RS, Brx1, Otlx2, ARP1)
PITX3
PITX1 (PTX1, POTX)
HOX{A4,D4}.p2 -0.146 -0.889 HOXA4
HOXD4
CDC5L.p2 -0.147 -0.499 CDC5L (PCDC5RP, hCDC5, CEF1)
NR1H4.p2 -0.148 -0.671 NR1H4 (FXR, RIP14, HRR1, HRR-1)
DBP.p2 -0.151 -1.126 DBP (DABP)
FOXL1.p2 -0.153 -0.922 FOXL1 (FREAC7, FKH6)
GFI1B.p2 -0.157 -0.442 GFI1B
HSF1,2.p2 -0.161 -1.101 HSF1 (HSTF1)
HSF2
AIRE.p2 -0.162 -0.415 AIRE (PGA1, APS1)
NKX3-1.p2 -0.165 -0.597 NKX3-1 (NKX3.1, BAPX2)
HNF4A_NR2F1,2.p2 -0.168 -1.572 NR2F1 (EAR-3, COUP-TFI, TCFCOUP1, SVP44)
NR2F2 (COUP-TFII, COUPTFB, SVP40)
HNF4A (NR2A1, HNF4)
ZNF238.p2 -0.177 -0.620 ZNF238 (C2H2-171, TAZ-1, RP58, ZBTB18)
ONECUT1,2.p2 -0.182 -0.747 ONECUT2 (OC-2)
ONECUT1 (HNF-6)
EOMES.p2 -0.188 -0.690 EOMES (TBR2)
SMAD1..7,9.p2 -0.194 -1.432 SMAD5 (Dwfc, JV5-1)
SMAD1 (MADR1, JV4-1)
SMAD3 (JV15-2, HsT17436)
SMAD4 (DPC4)
SMAD2 (MADR2, JV18-1)
SMAD6 (HsT17432)
SMAD7
SMAD9
PDX1.p2 -0.194 -0.232 PDX1 (IDX-1, STF-1, PDX-1, MODY4)
ALX1.p2 -0.200 -0.747 ALX1
FOXA2.p3 -0.211 -0.945 FOXA2
T.p2 -0.220 -0.392 T
FOSL2.p2 -0.220 -0.889 FOSL2 (FRA2, FLJ23306)
RXRA_VDR{dimer}.p2 -0.222 -0.485 VDR (NR1I1)
RORA.p2 -0.231 -0.391 RORA (RZRA, ROR1, ROR2, ROR3, NR1F1)
MSX1,2.p2 -0.245 -0.388 MSX1 (HYD1, OFC5)
MSX2 (CRS2, FPP, HOX8, MSH, PFM)
RUNX1..3.p2 -0.277 -1.776 RUNX1 (PEBP2A2, AMLCR1)
RUNX3 (AML2, PEBP2A3)
RUNX2 (AML3, PEBP2A1, PEBP2aA1)
NANOG{mouse}.p2 -0.278 -0.823 NANOG (FLJ12581, FLJ40451)
TBP.p2 -0.279 -1.166 TBP (TFIID)
TLX1..3_NFIC{dimer}.p2 -0.281 -1.268 TLX1
TLX3 (RNX)
POU6F1.p2 -0.291 -0.750 POU6F1 (BRN5, MPOU, TCFB1)
POU5F1_SOX2{dimer}.p2 -0.311 -1.007 POU5F1 (OCT3, Oct4, MGC22487)
SOX2
CEBPA,B_DDIT3.p2 -0.316 -0.722 DDIT3 (CHOP10, GADD153, CHOP)
CEBPA (C/EBP-alpha)
CEBPB (LAP, CRP2, NFIL6, IL6DBP)
POU1F1.p2 -0.321 -1.235 POU1F1 (GHF-1)
EVI1.p2 -0.321 -1.682 EVI1 (MDS1-EVI1, PRDM3)
PPARG.p2 -0.340 -0.661 PPARG (PPARG1, PPARG2, NR1C3, PPARgamma)
HOX{A5,B5}.p2 -0.353 -1.313 HOXB5
HOXA5
HOXA9_MEIS1.p2 -0.355 -0.615 MEIS1
HOXA9
FOX{C1,C2}.p2 -0.369 -0.864 FOXC1 (FREAC3, ARA, IGDA, IHG1)
FOXC2 (MFH-1)
ARID5B.p2 -0.390 -0.870 ARID5B (FLJ21150, MRF2)
HNF1A.p2 -0.392 -1.092 HNF1A (HNF1, LFB1)
NR3C1.p2 -0.399 -1.061 NR3C1 (GR)
GATA6.p2 -0.468 -1.736 GATA6
TAL1_TCF{3,4,12}.p2 -0.502 -0.975 TCF3 (E2A, ITF1, MGC129647, MGC129648, bHLHb21)
TCF4 (SEF2-1B, ITF2, bHLHb19)
TAL1 (SCL, bHLHa17)
TCF12 (HEB, HTF4, HsT17266, bHLHb20)
PAX6.p2 -0.508 -0.562 PAX6 (D11S812E, AN, WAGR)
HAND1,2.p2 -0.520 -1.791 HAND1 (eHand, Thing1, Hxt, bHLHa27)
HAND2 (dHand, Thing2, Hed, bHLHa26)
PAX8.p2 -0.533 -0.224 PAX8
FOXP3.p2 -0.536 -1.108 FOXP3 (JM2, XPID, AIID, PIDX, DIETER, SCURFIN)
EN1,2.p2 -0.581 -2.108 EN1
EN2
NKX2-1,4.p2 -0.665 -1.231 NKX2-1 (TTF-1)
NKX2-4 (NKX2.4)
AR.p2 -0.797 -0.977 AR (AIS, NR3C4, SMAX1, HUMARA)
REST.p3 -0.872 -2.062 REST (NRSF, XBR)
PAX3,7.p2 -2.322 -0.877 PAX7 (Hup1)
PAX3 (HUP2)