Motif ID: TLX2.p2

Z-value: 0.999


Transcription factors associated with TLX2.p2:

Gene SymbolEntrez IDGene Name
TLX2 3196 T-cell leukemia homeobox 2



Activity profile for motif TLX2.p2.

activity profile for motif TLX2.p2


Sorted Z-values histogram for motif TLX2.p2

Sorted Z-values for motif TLX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_8572277 1.697 STK33
serine/threonine kinase 33
chr11_-_8572321 1.687 STK33
serine/threonine kinase 33
chr11_-_8571988 1.422 NM_030906
STK33
serine/threonine kinase 33
chr13_-_40491491 0.926 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr7_-_112545840 0.925 LOC401397
hypothetical LOC401397
chr7_-_112545847 0.921 LOC401397
hypothetical LOC401397
chr13_-_40491405 0.907 ELF1
E74-like factor 1 (ets domain transcription factor)
chr3_+_123279439 0.872 NM_006889
CD86
CD86 molecule
chr8_+_18111894 0.845 NM_000662
NM_001160170
NM_001160171
NM_001160172
NM_001160173
NM_001160175
NM_001160176
NAT1






N-acetyltransferase 1 (arylamine N-acetyltransferase)






chr11_+_59979857 0.769 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr17_+_55269974 0.752


chr7_-_33047042 0.745 NM_001166118
NM_016489
NT5C3

5'-nucleotidase, cytosolic III

chr4_-_38534802 0.745 NM_006068
TLR6
toll-like receptor 6
chr11_-_83071084 0.743 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr19_+_55614006 0.735 NM_003121
SPIB
Spi-B transcription factor (Spi-1/PU.1 related)
chr6_+_160068135 0.707 NM_004906
NM_152858
WTAP

Wilms tumor 1 associated protein

chrX_-_70755023 0.706 NM_001142797
NM_001504
CXCR3

chemokine (C-X-C motif) receptor 3

chr11_-_62379788 0.706 SNHG1
small nucleolar RNA host gene 1 (non-protein coding)
chr9_+_94766379 0.695 FGD3
FYVE, RhoGEF and PH domain containing 3
chr17_+_7180571 0.681 NM_014716
ACAP1
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
chr11_-_95715976 0.681 NM_032427
MAML2
mastermind-like 2 (Drosophila)
chr16_+_2746363 0.677


chr7_+_31693155 0.673 NM_001145123
NM_006658
C7orf16

chromosome 7 open reading frame 16

chr20_+_56318415 0.658 RAB22A
RAB22A, member RAS oncogene family
chr7_-_26198673 0.646 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr1_+_159032551 0.637 NM_001033667
NM_002348
LY9

lymphocyte antigen 9

chr11_-_60880799 0.623 NM_001161452
CYBASC3
cytochrome b, ascorbate dependent 3
chr2_-_174536761 0.611 SP3
Sp3 transcription factor
chr1_-_155834357 0.604 NM_031282
FCRL4
Fc receptor-like 4
chr6_-_133126278 0.603 NM_078488
VNN2
vanin 2
chr3_+_153469421 0.598 MBNL1
muscleblind-like (Drosophila)
chr1_+_169549996 0.592 NM_002022
FMO4
flavin containing monooxygenase 4
chr7_+_134483305 0.585 NM_018295
TMEM140
transmembrane protein 140
chrX_-_73429101 0.584 MIR374AHG
mir-374a-545 cluster host gene (non-protein coding)
chr16_-_87535106 0.583 NM_175931
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr10_+_80672842 0.582 ZMIZ1
zinc finger, MIZ-type containing 1
chr2_+_233633348 0.581 INPP5D
inositol polyphosphate-5-phosphatase, 145kDa
chr1_+_26744929 0.577 NM_001006665
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr6_-_32665409 0.569 NM_002124
HLA-DRB1
HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr12_+_32578513 0.567 FGD4
FYVE, RhoGEF and PH domain containing 4
chr7_+_18296569 0.566 HDAC9
histone deacetylase 9
chr4_-_35922288 0.564 NM_015230
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr8_+_104496117 0.562 NM_015420
DCAF13
DDB1 and CUL4 associated factor 13
chr3_-_114176401 0.561 NM_138806
NM_138939
NM_138940
NM_170780
CD200R1



CD200 receptor 1



chr1_-_25164061 0.558 NM_001031680
RUNX3
runt-related transcription factor 3
chr16_+_31105579 0.557


chr12_+_14429499 0.553 ATF7IP
activating transcription factor 7 interacting protein
chr2_-_225519974 0.551 DOCK10
dedicator of cytokinesis 10
chr18_+_3237815 0.550 MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr2_-_188021117 0.548 NM_005795
CALCRL
calcitonin receptor-like
chrX_-_131181141 0.544 RAP2C
RAP2C, member of RAS oncogene family
chr18_+_3237774 0.543 MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr1_+_154095883 0.535 NM_152280
SYT11
synaptotagmin XI
chr7_+_150065594 0.532 GIMAP5
GTPase, IMAP family member 5
chr6_-_33028790 0.527 NM_006120
HLA-DMA
major histocompatibility complex, class II, DM alpha
chr17_+_59875623 0.526 NM_001085423
C17orf60
chromosome 17 open reading frame 60
chr1_-_203985752 0.525 NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr6_+_32713160 0.524 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr1_+_159899528 0.524 NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001
FCGR2B




FCGR2C
Fc fragment of IgG, low affinity IIb, receptor (CD32)




Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr6_+_26548678 0.519 NM_006994
NM_197974
BTN3A3

butyrophilin, subfamily 3, member A3

chr18_+_3237825 0.516 MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr2_+_233633279 0.514 NM_001017915
NM_005541
INPP5D

inositol polyphosphate-5-phosphatase, 145kDa

chr17_-_16816113 0.513 NM_012452
TNFRSF13B
tumor necrosis factor receptor superfamily, member 13B
chr10_-_50066386 0.512 NM_001010863
C10orf128
chromosome 10 open reading frame 128
chr3_-_151746589 0.510 SERP1
stress-associated endoplasmic reticulum protein 1
chr1_+_111573855 0.506 NM_001025199
CHI3L2
chitinase 3-like 2
chr6_+_32515596 0.505 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr1_+_53253204 0.502 SCP2
sterol carrier protein 2
chr1_+_159817752 0.496 NM_201563
FCGR2C
Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr1_-_155788775 0.495 NM_001195388
NM_031281
FCRL5

Fc receptor-like 5

chr1_-_9052170 0.490 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr21_+_29593098 0.488 BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr1_+_53253161 0.486 NM_001007099
NM_001007100
NM_001007250
SCP2


sterol carrier protein 2


chr5_+_68746694 0.486 NM_001038603
MARVELD2
MARVEL domain containing 2
chr15_-_32289561 0.484 NM_024713
C15orf29
chromosome 15 open reading frame 29
chr1_-_114215768 0.484 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr8_-_27997306 0.478 NM_001010906
C8orf80
chromosome 8 open reading frame 80
chr22_+_23153529 0.473 NM_000675
ADORA2A
adenosine A2a receptor
chr3_-_15814678 0.471 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr1_+_26744893 0.471 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr21_+_29593607 0.471 NM_206866
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr12_+_97513644 0.470 SLC25A3
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
chr1_-_203985701 0.467 NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr17_-_35975227 0.467 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr12_+_74160779 0.466 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr3_-_27385856 0.465 NM_199347
NEK10
NIMA (never in mitosis gene a)- related kinase 10
chr6_-_33862690 0.463 NM_001143944
LEMD2
LEM domain containing 2
chr18_+_58006154 0.460


chr19_-_6621078 0.457 TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chr6_-_127705244 0.457 NM_001139510
ECHDC1
enoyl CoA hydratase domain containing 1
chrX_+_78087484 0.454 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr3_-_178396892 0.454 TBL1XR1
transducin (beta)-like 1 X-linked receptor 1
chr21_+_29593088 0.451 NM_001186
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr1_-_87152372 0.451 SEP15
15 kDa selenoprotein
chr15_-_38185865 0.451 NM_033503
BMF
Bcl2 modifying factor
chr1_-_74436415 0.449 NM_001105659
LRRIQ3
leucine-rich repeats and IQ motif containing 3
chr6_+_147568795 0.444 STXBP5
syntaxin binding protein 5 (tomosyn)
chr12_+_12829807 0.443 NM_030817
APOLD1
apolipoprotein L domain containing 1
chr13_-_29321599 0.441 UBL3
ubiquitin-like 3
chr8_-_101384633 0.441 NM_015435
RNF19A
ring finger protein 19A
chr2_-_174537021 0.441 NM_001017371
SP3
Sp3 transcription factor
chr15_-_32289480 0.441 C15orf29
chromosome 15 open reading frame 29
chr1_+_74436507 0.440 NM_001112808
NM_003838
FPGT-TNNI3K
FPGT
FPGT-TNNI3K fusion protein
fucose-1-phosphate guanylyltransferase
chr1_-_9052207 0.438 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr1_+_24158898 0.437 PNRC2
proline-rich nuclear receptor coactivator 2
chr21_+_29592984 0.434 BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr3_-_145049853 0.433 NM_173653
SLC9A9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr16_+_73810383 0.430 NM_001906
CTRB1
CTRB2
chymotrypsinogen B1
chymotrypsinogen B2
chr20_-_1321571 0.427 FKBP1A
FK506 binding protein 1A, 12kDa
chr7_-_38341697 0.426 TRGV7
T cell receptor gamma variable 7 pseudogene
chr4_-_68093668 0.425


chr14_-_105392671 0.423


chr17_-_74231240 0.420 CYTH1
cytohesin 1
chr12_-_122322117 0.418 NM_004642
CDK2AP1
cyclin-dependent kinase 2 associated protein 1
chr13_-_44812246 0.414 TPT1
tumor protein, translationally-controlled 1
chr9_+_70509925 0.413 NM_003558
PIP5K1B
phosphatidylinositol-4-phosphate 5-kinase, type I, beta
chr4_-_68093784 0.411 CENPC1
centromere protein C 1
chr7_-_38355949 0.410


chr3_-_114898003 0.408 NM_001009899
KIAA2018
KIAA2018
chr1_-_87152396 0.407 SEP15
15 kDa selenoprotein
chr3_+_101694244 0.405 TMEM45A
transmembrane protein 45A
chr6_-_159386007 0.405 NM_054114
NM_138810
NM_152133
TAGAP


T-cell activation RhoGTPase activating protein


chr1_+_198263352 0.403 NM_003822
NM_205860
NR5A2

nuclear receptor subfamily 5, group A, member 2

chr10_+_26767698 0.401 APBB1IP
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr2_+_63669596 0.399 NM_005917
MDH1
malate dehydrogenase 1, NAD (soluble)
chr2_+_149349643 0.398


chr3_+_123256902 0.396 NM_175862
CD86
CD86 molecule
chr6_-_31658044 0.396 NM_002341
NM_009588
LTB

lymphotoxin beta (TNF superfamily, member 3)

chr1_+_207995999 0.394 NM_025228
TRAF3IP3
TRAF3 interacting protein 3
chr5_+_40877053 0.394 NM_032587
CARD6
caspase recruitment domain family, member 6
chr16_-_29664765 0.393 NM_175900
C16orf54
chromosome 16 open reading frame 54
chr14_-_20807346 0.390 NM_001077442
NM_001077443
NM_004500
NM_031314
HNRNPC



heterogeneous nuclear ribonucleoprotein C (C1/C2)



chrX_+_117364444 0.390 WDR44
WD repeat domain 44
chr15_-_38185578 0.386 NM_001003942
NM_001003943
BMF

Bcl2 modifying factor

chr7_+_139175420 0.385 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr4_-_105635499 0.384 CXXC4
CXXC finger protein 4
chr11_-_3775282 0.384 NUP98
nucleoporin 98kDa
chr18_-_53438854 0.383


chr12_+_15955549 0.381 DERA
deoxyribose-phosphate aldolase (putative)
chr19_-_56612653 0.381 NM_001171156
NM_001171157
NM_001171158
NM_001171159
NM_001171160
NM_001171161
NM_033130
SIGLEC10






sialic acid binding Ig-like lectin 10






chr8_-_117837240 0.381 NM_003756
EIF3H
eukaryotic translation initiation factor 3, subunit H
chr20_+_61838389 0.378 NM_017806
LIME1
Lck interacting transmembrane adaptor 1
chr15_+_40481879 0.377 NM_173088
CAPN3
calpain 3, (p94)
chr1_-_159257486 0.377 F11R
F11 receptor
chr8_-_117837224 0.376 EIF3H
eukaryotic translation initiation factor 3, subunit H
chr3_-_33456505 0.376 UBP1
upstream binding protein 1 (LBP-1a)
chr1_+_246167115 0.376 NM_175911
OR2L13
olfactory receptor, family 2, subfamily L, member 13
chr10_+_86174665 0.374 FAM190B
family with sequence similarity 190, member B
chr1_-_205161821 0.374 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr19_-_13074513 0.372 LYL1
lymphoblastic leukemia derived sequence 1
chr14_+_101346032 0.372 PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr11_-_127897098 0.371 ETS1
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
chr1_-_159257567 0.368 F11R
F11 receptor
chr20_-_14266200 0.368 NM_013281
NM_198391
FLRT3

fibronectin leucine rich transmembrane protein 3

chr17_-_46140015 0.367 NM_052855
ANKRD40
ankyrin repeat domain 40
chr17_-_44641741 0.367 NM_031498
NM_001198755
NM_001198756
GNGT2


guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2


chr6_-_32605898 0.366 NM_002125
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr8_+_73612179 0.364 NM_004770
KCNB2
potassium voltage-gated channel, Shab-related subfamily, member 2
chr19_-_6671585 0.363 NM_000064
C3
complement component 3
chrX_+_84145487 0.362 NM_198450
APOOL
apolipoprotein O-like
chr1_+_205561709 0.357 CD55
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
chr8_-_117837202 0.356 EIF3H
eukaryotic translation initiation factor 3, subunit H
chr16_-_30301357 0.355 SEPT1
septin 1
chr2_+_102345528 0.354 NM_003855
IL18R1
interleukin 18 receptor 1
chr19_+_49943773 0.354 NM_005178
BCL3
B-cell CLL/lymphoma 3
chr4_-_68093829 0.351 NM_001812
CENPC1
centromere protein C 1
chr7_-_149960218 0.349 GIMAP6
GTPase, IMAP family member 6
chr7_-_11838260 0.349 NM_015204
THSD7A
thrombospondin, type I, domain containing 7A
chr4_+_154345039 0.348 NM_015271
TRIM2
tripartite motif containing 2
chr6_-_127706204 0.348 ECHDC1
enoyl CoA hydratase domain containing 1
chr11_+_34894688 0.348 PDHX
pyruvate dehydrogenase complex, component X
chr9_+_124066973 0.346 MRRF
mitochondrial ribosome recycling factor
chr17_-_44022595 0.345 HOXB3
homeobox B3
chr1_-_149115667 0.345 ARNT
aryl hydrocarbon receptor nuclear translocator
chr4_+_38722593 0.343 NM_001007075
NM_001171654
KLHL5

kelch-like 5 (Drosophila)

chr10_+_26767657 0.342 APBB1IP
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr7_+_150065376 0.342 NM_018384
GIMAP5
GTPase, IMAP family member 5
chr3_-_150578023 0.342 TM4SF1
transmembrane 4 L six family member 1
chr10_-_32384914 0.341


chr20_+_42463419 0.341 HNF4A
hepatocyte nuclear factor 4, alpha
chr1_+_205561693 0.340 CD55
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
chr1_-_27825633 0.340 NM_001042729
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chr1_-_149115686 0.338 ARNT
aryl hydrocarbon receptor nuclear translocator
chr11_-_128217550 0.338 NM_000220
KCNJ1
potassium inwardly-rectifying channel, subfamily J, member 1
chr2_-_79168626 0.337 NM_006507
REG1B
regenerating islet-derived 1 beta
chr2_+_231968578 0.336 NM_145236
B3GNT7
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
chr7_-_22363036 0.332 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr17_-_73640082 0.332 NM_007267
TMC6
transmembrane channel-like 6
chr8_+_55210333 0.332 NM_014175
MRPL15
mitochondrial ribosomal protein L15
chr15_+_89444433 0.331 NM_014848
SV2B
synaptic vesicle glycoprotein 2B
chr21_-_46528594 0.330 MCM3AP
minichromosome maintenance complex component 3 associated protein
chr17_-_74231266 0.330 CYTH1
cytohesin 1
chr9_-_19368815 0.328 RPS6
ribosomal protein S6
chr3_-_46224791 0.328 NM_001295
CCR1
chemokine (C-C motif) receptor 1
chr1_+_205561632 0.328 CD55
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
chr15_+_89444556 0.327 SV2B
synaptic vesicle glycoprotein 2B
chr16_-_70763524 0.326 NM_031293
PMFBP1
polyamine modulated factor 1 binding protein 1
chr12_-_52960146 0.326 CBX5
chromobox homolog 5
chrX_+_108666725 0.326 NXT2
nuclear transport factor 2-like export factor 2
chr6_+_26473376 0.326 NM_001197247
NM_001197249
NM_007047
NM_001197248
BTN3A2



butyrophilin, subfamily 3, member A2




Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.49 4.65e-04 GO:0002376 immune system process
1.64 1.81e-03 GO:0002682 regulation of immune system process
1.84 3.67e-03 GO:0006886 intracellular protein transport
1.09 5.56e-03 GO:0009987 cellular process
1.75 9.40e-03 GO:0050776 regulation of immune response
1.54 1.52e-02 GO:0046907 intracellular transport
1.44 2.09e-02 GO:0051649 establishment of localization in cell
1.14 2.35e-02 GO:0008152 metabolic process
1.15 3.22e-02 GO:0044238 primary metabolic process
2.02 3.22e-02 GO:0002253 activation of immune response

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.22 4.98e-07 GO:0044446 intracellular organelle part
1.22 8.42e-07 GO:0044422 organelle part
1.15 1.33e-06 GO:0005737 cytoplasm
1.13 2.30e-06 GO:0043229 intracellular organelle
1.13 2.69e-06 GO:0043226 organelle
1.14 1.27e-05 GO:0043227 membrane-bounded organelle
1.14 1.32e-05 GO:0043231 intracellular membrane-bounded organelle
1.27 3.42e-05 GO:0032991 macromolecular complex
1.10 3.46e-05 GO:0044424 intracellular part
1.18 5.74e-05 GO:0044444 cytoplasmic part
1.36 7.98e-05 GO:0005829 cytosol
1.09 1.05e-04 GO:0005622 intracellular
1.26 1.64e-03 GO:0043234 protein complex
1.28 3.59e-03 GO:0031974 membrane-enclosed lumen
1.28 5.47e-03 GO:0043233 organelle lumen
2.21 7.19e-03 GO:0044445 cytosolic part
1.27 1.24e-02 GO:0070013 intracellular organelle lumen
1.27 2.36e-02 GO:0031090 organelle membrane
1.22 4.38e-02 GO:0043228 non-membrane-bounded organelle
1.22 4.38e-02 GO:0043232 intracellular non-membrane-bounded organelle

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.15 1.30e-04 GO:0005515 protein binding
2.65 1.23e-02 GO:0008565 protein transporter activity