Motif ID: ESR1.p2

Z-value: 1.861


Transcription factors associated with ESR1.p2:

Gene SymbolEntrez IDGene Name
ESR1 2099 estrogen receptor 1



Activity profile for motif ESR1.p2.

activity profile for motif ESR1.p2


Sorted Z-values histogram for motif ESR1.p2

Sorted Z-values for motif ESR1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ESR1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_6622051 2.831 NM_017560
ZNF853
zinc finger protein 853
chr19_+_15079141 2.676 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr9_-_85342868 2.520 NM_174938
FRMD3
FERM domain containing 3
chr12_-_123568781 2.220


chr13_+_75108450 2.065 LMO7
LIM domain 7
chr2_+_238200922 1.898 NM_001137550
LRRFIP1
leucine rich repeat (in FLII) interacting protein 1
chr10_+_115428924 1.829 NM_033340
CASP7
caspase 7, apoptosis-related cysteine peptidase
chr9_-_83493415 1.720 NM_005077
TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr14_+_78815406 1.698 NM_001105250
NM_138970
NRXN3

neurexin 3

chr2_+_100802923 1.655 NM_002518
NPAS2
neuronal PAS domain protein 2
chr3_-_135852514 1.640 NM_178554
KY
kyphoscoliosis peptidase
chr14_+_105063975 1.637 NM_025268
TMEM121
transmembrane protein 121
chr11_-_70641267 1.633 SHANK2
SH3 and multiple ankyrin repeat domains 2
chr22_-_41447214 1.630 A4GALT
alpha 1,4-galactosyltransferase
chr10_+_129595289 1.629 NM_006504
PTPRE
protein tyrosine phosphatase, receptor type, E
chr1_+_77520315 1.589 NM_174858
AK5
adenylate kinase 5
chr1_+_179148935 1.557 NM_020950
KIAA1614
KIAA1614
chr2_+_36436316 1.541 CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr17_-_7238546 1.532 NM_020360
PLSCR3
phospholipid scramblase 3
chr19_+_58733144 1.474 NM_001079906
ZNF331
zinc finger protein 331
chr1_+_77520874 1.434 NM_012093
AK5
adenylate kinase 5
chrX_-_71442488 1.427 NM_001144885
NM_001144887
CITED1

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1

chr7_-_47588160 1.385 TNS3
tensin 3
chr6_+_17389752 1.361 NM_001143942
RBM24
RNA binding motif protein 24
chr11_-_1549719 1.348 NM_004420
DUSP8
dual specificity phosphatase 8
chr11_-_72530605 1.301 NM_014824
FCHSD2
FCH and double SH3 domains 2
chr19_-_10091534 1.301 NM_003755
EIF3G
eukaryotic translation initiation factor 3, subunit G
chr22_-_41446740 1.281 NM_017436
A4GALT
alpha 1,4-galactosyltransferase
chr19_-_8581559 1.273 NM_030957
ADAMTS10
ADAM metallopeptidase with thrombospondin type 1 motif, 10
chr9_-_16860719 1.273 NM_017637
BNC2
basonuclin 2
chr7_+_128615948 1.272 NM_005631
SMO
smoothened homolog (Drosophila)
chr10_-_62883213 1.268 NM_178505
TMEM26
transmembrane protein 26
chr16_+_29734785 1.257 C16orf53
chromosome 16 open reading frame 53
chr6_+_158877455 1.257 NM_020823
TMEM181
transmembrane protein 181
chr3_-_135231417 1.255 SLCO2A1
solute carrier organic anion transporter family, member 2A1
chr7_-_47588266 1.238 TNS3
tensin 3
chr4_+_151218862 1.233 NM_001040260
NM_001040261
DCLK2

doublecortin-like kinase 2

chr16_-_73842884 1.226 NM_001170717
NM_014567
BCAR1

breast cancer anti-estrogen resistance 1

chr10_-_62882930 1.212 TMEM26
transmembrane protein 26
chr17_-_24068759 1.192 NM_001144942
NM_031934
RAB34

RAB34, member RAS oncogene family

chr5_+_178219519 1.188 NM_058230
ZNF354B
zinc finger protein 354B
chr12_-_93568336 1.181 NM_020698
TMCC3
transmembrane and coiled-coil domain family 3
chr13_-_32822759 1.174 STARD13
StAR-related lipid transfer (START) domain containing 13
chr6_+_30002084 1.171


chr1_-_151852128 1.166 NM_080388
S100A16
S100 calcium binding protein A16
chr9_+_89302574 1.163 NM_004938
DAPK1
death-associated protein kinase 1
chr9_-_16860664 1.154 BNC2
basonuclin 2
chr18_+_75825563 1.146 NM_001136180
HSBP1L1
heat shock factor binding protein 1-like 1
chr7_+_45894480 1.139 NM_000596
IGFBP1
insulin-like growth factor binding protein 1
chr2_+_149894744 1.133 NM_001195685
LYPD6
LY6/PLAUR domain containing 6
chr4_+_184257337 1.131 NM_024949
WWC2
WW and C2 domain containing 2
chr16_+_54072969 1.120 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr1_+_31659246 1.099 NM_001199039
NM_018565
SERINC2

serine incorporator 2

chr13_+_109757593 1.094 NM_001846
COL4A2
collagen, type IV, alpha 2
chr11_+_128266460 1.086 NM_000890
KCNJ5
potassium inwardly-rectifying channel, subfamily J, member 5
chr2_+_85213884 1.084 NM_031283
TCF7L1
transcription factor 7-like 1 (T-cell specific, HMG-box)
chr6_+_17501589 1.082 NM_006366
CAP2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr19_+_61711008 1.079 NM_020813
ZNF471
zinc finger protein 471
chr15_+_30797466 1.076 NM_001191322
NM_001191323
NM_013372
GREM1


gremlin 1


chr10_-_133971136 1.068 NM_173575
STK32C
serine/threonine kinase 32C
chr14_+_99273751 1.066 EML1
echinoderm microtubule associated protein like 1
chr22_+_42651018 1.062 PNPLA3
patatin-like phospholipase domain containing 3
chr11_+_1846478 1.054 NM_001013253
LSP1
lymphocyte-specific protein 1
chr10_-_105410840 1.048


chr7_+_1543644 1.032 MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr3_-_135231518 1.028 NM_005630
SLCO2A1
solute carrier organic anion transporter family, member 2A1
chr19_-_41191423 1.026 NM_001039876
C19orf46
chromosome 19 open reading frame 46
chr13_-_25523164 1.021 NM_001007538
SHISA2
shisa homolog 2 (Xenopus laevis)
chr12_+_19173669 1.009 NM_001143821
NM_001190860
NM_019012
PLEKHA5


pleckstrin homology domain containing, family A member 5


chr16_+_81218142 1.002 CDH13
cadherin 13, H-cadherin (heart)
chr8_+_32525269 0.996 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
NRG1










neuregulin 1










chr6_+_45498354 0.989 RUNX2
runt-related transcription factor 2
chr9_+_137532294 0.978 NM_016034
MRPS2
mitochondrial ribosomal protein S2
chr1_+_77520190 0.970 AK5
adenylate kinase 5
chr5_-_156935317 0.968 NM_033274
ADAM19
ADAM metallopeptidase domain 19
chr9_+_89302239 0.962 DAPK1
death-associated protein kinase 1
chr1_+_15955719 0.959 FBLIM1
filamin binding LIM protein 1
chr22_+_36632242 0.949 NM_033386
MICALL1
MICAL-like 1
chr11_-_118716244 0.946 MFRP
membrane frizzled-related protein
chr5_-_178090203 0.942 NM_005649
ZNF354A
zinc finger protein 354A
chr6_+_7486862 0.942 NM_001008844
NM_004415
DSP

desmoplakin

chr6_+_158877640 0.936 TMEM181
transmembrane protein 181
chr22_-_19122047 0.935 SCARF2
scavenger receptor class F, member 2
chr8_+_63324053 0.934 NM_173688
NKAIN3
Na+/K+ transporting ATPase interacting 3
chr13_+_112671497 0.933 MCF2L
MCF.2 cell line derived transforming sequence-like
chr14_+_95575319 0.931 C14orf132
chromosome 14 open reading frame 132
chr8_+_16929116 0.928 NM_181723
EFHA2
EF-hand domain family, member A2
chr2_+_242398832 0.925 NM_001167600
NM_001167601
NEU4

sialidase 4

chr6_-_117193505 0.920 NM_001085480
FAM162B
family with sequence similarity 162, member B
chr4_-_118226119 0.909 NM_152402
TRAM1L1
translocation associated membrane protein 1-like 1
chr9_+_136673464 0.904 NM_000093
COL5A1
collagen, type V, alpha 1
chr22_+_42651007 0.904 PNPLA3
patatin-like phospholipase domain containing 3
chr6_+_7486836 0.902 DSP
desmoplakin
chr17_+_59429442 0.901 NM_001164257
NM_001191029
NM_001191030
NM_001191031
C17orf72



chromosome 17 open reading frame 72



chr22_-_36245155 0.887 NM_014550
CARD10
caspase recruitment domain family, member 10
chr7_-_29995809 0.887 NM_001145515
NM_014766
NM_001145513
SCRN1


secernin 1


chr5_-_178983281 0.886 NM_005520
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr3_+_8750485 0.885 NM_033337
NM_001234
CAV3

caveolin 3

chr2_+_97628929 0.884 NM_001862
COX5B
cytochrome c oxidase subunit Vb
chr5_-_156935283 0.882


chr22_+_42650951 0.875 NM_025225
PNPLA3
patatin-like phospholipase domain containing 3
chr20_-_36322587 0.874 NM_001029864
KIAA1755
KIAA1755
chr15_-_50375143 0.872 NM_018728
MYO5C
myosin VC
chr16_+_81218074 0.866 NM_001257
CDH13
cadherin 13, H-cadherin (heart)
chr1_-_29322993 0.861 NM_001003682
TMEM200B
transmembrane protein 200B
chr22_-_19122107 0.857 NM_153334
NM_182895
SCARF2

scavenger receptor class F, member 2

chr6_+_7486891 0.856 DSP
desmoplakin
chr2_+_39746525 0.854 NM_152390
TMEM178
transmembrane protein 178
chr1_+_213323182 0.850 NM_001017425
NM_014217
KCNK2

potassium channel, subfamily K, member 2

chr16_-_265868 0.847 NM_003834
NM_183337
RGS11

regulator of G-protein signaling 11

chr18_-_72973698 0.828 MBP
myelin basic protein
chr19_-_15172773 0.826 NM_000435
NOTCH3
notch 3
chr11_-_75599433 0.820 WNT11
wingless-type MMTV integration site family, member 11
chr1_-_239587007 0.820 RGS7
regulator of G-protein signaling 7
chr12_-_119291276 0.818 NM_002442
MSI1
musashi homolog 1 (Drosophila)
chr14_+_105024301 0.808 NM_001311
CRIP1
cysteine-rich protein 1 (intestinal)
chr5_-_178983241 0.806 HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr7_-_27190882 0.804 HOXA11
homeobox A11
chr2_+_242398954 0.804 NEU4
sialidase 4
chr14_-_23686269 0.802 PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr6_+_133604203 0.796 EYA4
eyes absent homolog 4 (Drosophila)
chr2_+_219354692 0.794 NM_000784
CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr6_+_148705421 0.793 NM_015278
SASH1
SAM and SH3 domain containing 1
chr10_-_105411339 0.793 SH3PXD2A
SH3 and PX domains 2A
chr16_+_29819647 0.792 NM_181718
ASPHD1
aspartate beta-hydroxylase domain containing 1
chr19_+_62703136 0.792 ZNF773
zinc finger protein 773
chr5_-_37285160 0.786 NM_023073
C5orf42
chromosome 5 open reading frame 42
chr21_-_26867138 0.785 NM_052954
CYYR1
cysteine/tyrosine-rich 1
chr10_+_122206455 0.779 NM_001030059
PPAPDC1A
phosphatidic acid phosphatase type 2 domain containing 1A
chr2_-_198358253 0.777 NM_033030
BOLL
bol, boule-like (Drosophila)
chr17_-_8006979 0.776 NM_014232
VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr19_+_58750305 0.775 NM_001079907
ZNF331
zinc finger protein 331
chr16_+_971808 0.769 NM_014587
SOX8
SRY (sex determining region Y)-box 8
chr6_+_3696224 0.763


chr2_+_242289983 0.762 NM_032329
ING5
inhibitor of growth family, member 5
chr3_+_52504391 0.757 NM_015136
STAB1
stabilin 1
chr16_+_29734990 0.754 NM_024516
C16orf53
chromosome 16 open reading frame 53
chr9_+_71848555 0.753 MAMDC2
MAM domain containing 2
chr16_+_57106883 0.748 NM_001160305
NM_024860
SETD6

SET domain containing 6

chr14_+_23855291 0.747 LTB4R
leukotriene B4 receptor
chr14_+_23686547 0.743 RNF31
ring finger protein 31
chr20_+_19945930 0.740 NM_016100
NM_181528
NAA20

N(alpha)-acetyltransferase 20, NatB catalytic subunit

chr20_+_23279372 0.740 NM_013248
NXT1
NTF2-like export factor 1
chr14_+_23686498 0.739 NM_017999
RNF31
ring finger protein 31
chr19_+_62703113 0.735 NM_198542
ZNF773
zinc finger protein 773
chr16_+_28893525 0.725 NM_001142448
NM_001142449
NM_001142450
NM_001142451
NM_032038
SPIN1
SPNS1




spindlin 1
spinster homolog 1 (Drosophila)




chr6_-_154873396 0.720 NM_173515
CNKSR3
CNKSR family member 3
chr15_-_49174107 0.718 TNFAIP8L3
tumor necrosis factor, alpha-induced protein 8-like 3
chr22_+_44925162 0.714 NM_001001928
NM_005036
PPARA

peroxisome proliferator-activated receptor alpha

chr3_-_197201497 0.712 SDHAP1
SDHAP2
succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 1
succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 2
chr19_-_19245022 0.712 NM_001001524
TM6SF2
transmembrane 6 superfamily member 2
chr20_+_61842880 0.711 SLC2A4RG
SLC2A4 regulator
chr17_+_77779570 0.710 NM_001042422
SLC16A3
solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
chr20_+_3775421 0.709 NM_020746
MAVS
mitochondrial antiviral signaling protein
chr20_+_4077466 0.708 SMOX
spermine oxidase
chr2_-_232037454 0.706 NCL
nucleolin
chr15_-_88034857 0.703 NM_003847
PEX11A
peroxisomal biogenesis factor 11 alpha
chr7_-_72676750 0.702 NM_032951
NM_032952
NM_032953
NM_032954
MLXIPL



MLX interacting protein-like



chr1_-_1346465 0.700 NM_001145210
LOC441869
hypothetical protein LOC441869
chr4_-_9632192 0.700 NM_020041
SLC2A9
solute carrier family 2 (facilitated glucose transporter), member 9
chr20_+_30161173 0.699 TM9SF4
transmembrane 9 superfamily protein member 4
chr14_+_53933422 0.697 NM_001130851
NM_005192
CDKN3

cyclin-dependent kinase inhibitor 3

chr5_+_167889123 0.691


chr18_+_59788242 0.688 NM_001031848
NM_002640
NM_198833
SERPINB8


serpin peptidase inhibitor, clade B (ovalbumin), member 8


chr16_-_1600654 0.687 IFT140
intraflagellar transport 140 homolog (Chlamydomonas)
chr20_+_30160952 0.686 NM_014742
TM9SF4
transmembrane 9 superfamily protein member 4
chr10_-_30388439 0.686 NM_020848
KIAA1462
KIAA1462
chr4_+_79197747 0.683 NM_001166133
NM_025074
FRAS1

Fraser syndrome 1

chr6_-_153494076 0.683 NM_012419
RGS17
regulator of G-protein signaling 17
chr7_-_127788893 0.682 NM_001114726
NM_001174164
PRRT4

proline-rich transmembrane protein 4

chr16_+_66244314 0.678 RLTPR
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr20_-_3696344 0.677 NM_001039140
C20orf27
chromosome 20 open reading frame 27
chr18_-_72973750 0.675 NM_001025100
NM_001025101
MBP

myelin basic protein

chr13_-_43259032 0.671 NM_017993
ENOX1
ecto-NOX disulfide-thiol exchanger 1
chr3_-_170970296 0.670 NM_032487
ARPM1
actin related protein M1
chr9_-_139202855 0.669 NM_013366
ANAPC2
anaphase promoting complex subunit 2
chr2_+_236067424 0.669 NM_001037131
NM_014914
AGAP1

ArfGAP with GTPase domain, ankyrin repeat and PH domain 1

chr6_-_11152340 0.668 NM_017770
ELOVL2
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2
chr2_-_222871577 0.665 NM_000438
NM_001127366
NM_013942
NM_181457
NM_181458
NM_181459
NM_181460
NM_181461
PAX3







paired box 3







chr3_-_66633534 0.661 NM_015541
LRIG1
leucine-rich repeats and immunoglobulin-like domains 1
chr19_+_41177882 0.661 NM_001042631
SDHAF1
succinate dehydrogenase complex assembly factor 1
chr21_+_45649719 0.659


chr4_+_4912272 0.658 NM_002448
MSX1
msh homeobox 1
chr17_+_31082791 0.656 NM_033315
RASL10B
RAS-like, family 10, member B
chr9_+_139202874 0.654 NM_003731
SSNA1
Sjogren syndrome nuclear autoantigen 1
chr16_+_658081 0.653 NM_138769
RHOT2
ras homolog gene family, member T2
chr10_+_129595349 0.653 PTPRE
protein tyrosine phosphatase, receptor type, E
chr5_-_1165106 0.651 NM_006598
SLC12A7
solute carrier family 12 (potassium/chloride transporters), member 7
chr6_+_52334825 0.651 NM_133367
PAQR8
progestin and adipoQ receptor family member VIII
chr1_-_94475840 0.649 NM_004815
ARHGAP29
Rho GTPase activating protein 29
chr6_+_107917965 0.649 NM_018013
SOBP
sine oculis binding protein homolog (Drosophila)
chr19_+_47521600 0.648 NM_001410
MEGF8
multiple EGF-like-domains 8
chr5_-_131375148 0.648 NM_001009185
NM_015256
ACSL6

acyl-CoA synthetase long-chain family member 6

chr9_-_21999270 0.647 NM_004936
NM_078487
CDKN2B

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

chr19_-_971995 0.646 C19orf6
chromosome 19 open reading frame 6
chr11_-_2118916 0.645 NM_001127598
IGF2
insulin-like growth factor 2 (somatomedin A)
chr8_+_123863224 0.644 ZHX2
zinc fingers and homeoboxes 2
chr14_+_101500650 0.644 DYNC1H1
dynein, cytoplasmic 1, heavy chain 1
chr15_+_72695248 0.642 CLK3
CDC-like kinase 3
chr6_+_148705646 0.640 SASH1
SAM and SH3 domain containing 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.25 1.15e-04 GO:0032502 developmental process
1.34 6.41e-04 GO:0030154 cell differentiation
1.24 8.54e-04 GO:0007275 multicellular organismal development
1.15 1.06e-03 GO:0050794 regulation of cellular process
1.33 1.13e-03 GO:0048869 cellular developmental process
1.39 1.97e-03 GO:0007399 nervous system development
1.23 9.80e-03 GO:0048856 anatomical structure development
1.25 1.30e-02 GO:0048731 system development
1.12 1.44e-02 GO:0065007 biological regulation
1.29 1.72e-02 GO:0048523 negative regulation of cellular process
2.25 1.98e-02 GO:0006820 anion transport
1.35 2.13e-02 GO:0009653 anatomical structure morphogenesis
1.12 2.98e-02 GO:0050789 regulation of biological process
1.26 3.26e-02 GO:0048519 negative regulation of biological process
2.64 4.57e-02 GO:0007015 actin filament organization
1.87 4.59e-02 GO:0030036 actin cytoskeleton organization

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.15 4.02e-05 GO:0005515 protein binding
1.79 3.44e-03 GO:0003779 actin binding
1.48 9.69e-03 GO:0019899 enzyme binding
1.55 1.68e-02 GO:0008092 cytoskeletal protein binding
1.07 2.18e-02 GO:0005488 binding