Motif ID: ZEB1.p2

Z-value: 2.724


Transcription factors associated with ZEB1.p2:

Gene SymbolEntrez IDGene Name
ZEB1 6935 zinc finger E-box binding homeobox 1



Activity profile for motif ZEB1.p2.

activity profile for motif ZEB1.p2


Sorted Z-values histogram for motif ZEB1.p2

Sorted Z-values for motif ZEB1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZEB1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_6415259 11.647 NM_139161
NM_174881
CRB3

crumbs homolog 3 (Drosophila)

chr19_+_43447262 9.886 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr19_+_43447078 9.768 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr22_+_38720881 9.385 NM_138435
FAM83F
family with sequence similarity 83, member F
chr19_+_43446937 8.997 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr7_-_22363036 8.772 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr4_-_35922288 6.799 NM_015230
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr1_-_27159462 6.518 NM_152365
C1orf172
chromosome 1 open reading frame 172
chr19_+_40431359 6.194 NM_015925
NM_205834
NM_205835
LSR


lipolysis stimulated lipoprotein receptor


chr19_+_40431618 6.185 LSR
lipolysis stimulated lipoprotein receptor
chr8_+_120289735 5.481 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr1_+_60053050 4.763 NM_015888
HOOK1
hook homolog 1 (Drosophila)
chr19_+_7566698 4.754 NM_001080429
NM_020902
KIAA1543

KIAA1543

chr11_-_64368616 4.692 NM_017525
CDC42BPG
CDC42 binding protein kinase gamma (DMPK-like)
chr19_+_40431678 4.587 LSR
lipolysis stimulated lipoprotein receptor
chr1_+_1971762 4.530 NM_002744
PRKCZ
protein kinase C, zeta
chr8_-_144887876 4.324 NM_198488
FAM83H
family with sequence similarity 83, member H
chr19_+_40431122 4.307 LSR
lipolysis stimulated lipoprotein receptor
chr18_-_45975163 4.192 NM_001080467
MYO5B
myosin VB
chr7_+_147667461 4.045 CNTNAP2
contactin associated protein-like 2
chr16_-_66827449 3.823 NM_024939
ESRP2
epithelial splicing regulatory protein 2
chr7_+_26298018 3.698 NM_013322
SNX10
sorting nexin 10
chr2_-_166358951 3.557 GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr2_-_166358792 3.486 GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr11_+_32808045 3.426 NM_024081
PRRG4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr8_+_95722448 3.414 ESRP1
epithelial splicing regulatory protein 1
chr6_-_10527772 3.409 NM_001042425
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr16_+_67328715 3.380 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr16_+_67328693 3.371 NM_004360
CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr2_-_166359016 3.278 NM_004482
GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr17_+_71229191 3.228 ITGB4
integrin, beta 4
chr21_-_41140908 3.225 NM_001389
DSCAM
Down syndrome cell adhesion molecule
chr17_+_71229151 3.205 ITGB4
integrin, beta 4
chr17_+_71229110 3.180 NM_000213
NM_001005731
ITGB4

integrin, beta 4

chr21_-_42060266 3.139 NM_020639
RIPK4
receptor-interacting serine-threonine kinase 4
chr1_-_208046011 3.121 NM_006147
IRF6
interferon regulatory factor 6
chr12_+_6926014 3.083 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr16_+_67236730 3.082 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr14_+_71468902 3.079 RGS6
regulator of G-protein signaling 6
chr10_-_62163083 3.048 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr7_+_26298136 3.035 SNX10
sorting nexin 10
chr17_+_26839143 3.014 RAB11FIP4
RAB11 family interacting protein 4 (class II)
chr21_-_42060334 2.984 RIPK4
receptor-interacting serine-threonine kinase 4
chr3_+_10832867 2.979 NM_014229
SLC6A11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr18_+_27332024 2.976 NM_001943
DSG2
desmoglein 2
chr5_+_68746694 2.944 NM_001038603
MARVELD2
MARVEL domain containing 2
chr16_+_70217564 2.847 NM_001017967
NM_052858
MARVELD3

MARVEL domain containing 3

chr17_-_40866062 2.791 NM_174919
SH3D20
SH3 domain containing 20
chr16_+_67328805 2.759 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr6_+_36206239 2.734 NM_002754
MAPK13
mitogen-activated protein kinase 13
chr2_+_222997529 2.697 NM_152386
SGPP2
sphingosine-1-phosphate phosphatase 2
chr17_+_71033339 2.692 NM_001015002
NM_001031803
NM_004524
LLGL2


lethal giant larvae homolog 2 (Drosophila)


chr17_-_60208083 2.606 LOC146880
hypothetical LOC146880
chr2_+_222997456 2.596 SGPP2
sphingosine-1-phosphate phosphatase 2
chr8_-_75396016 2.569 NM_020647
JPH1
junctophilin 1
chr2_-_121759237 2.540 NM_014553
TFCP2L1
transcription factor CP2-like 1
chr21_-_41140457 2.517 DSCAM
Down syndrome cell adhesion molecule
chr14_-_66948523 2.445 NM_016445
PLEK2
pleckstrin 2
chr14_-_66948612 2.418 PLEK2
pleckstrin 2
chr16_+_67328737 2.390 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr5_+_167651063 2.304 NM_001161661
NM_001161662
NM_015238
WWC1


WW and C2 domain containing 1


chr8_+_86563382 2.297 NM_000067
CA2
carbonic anhydrase II
chr19_+_7608020 2.260 STXBP2
syntaxin binding protein 2
chr12_+_6925997 2.244 NM_080548
PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr19_+_7608015 2.225 STXBP2
syntaxin binding protein 2
chr19_+_7608010 2.216 STXBP2
syntaxin binding protein 2
chr2_-_224410444 2.196 AP1S3
adaptor-related protein complex 1, sigma 3 subunit
chr19_+_7607976 2.181 NM_001127396
NM_006949
STXBP2

syntaxin binding protein 2

chr17_-_40865987 2.180 SH3D20
SH3 domain containing 20
chr19_-_7607852 2.074


chr19_-_60587414 2.063 NM_001190764
LOC388564
hypothetical protein LOC388564
chr2_-_224410544 2.054 NM_001039569
AP1S3
adaptor-related protein complex 1, sigma 3 subunit
chr12_-_51200347 2.022 NM_000424
KRT5
keratin 5
chr21_+_42807052 2.021 SLC37A1
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr1_-_158182006 2.002 NM_001135050
NM_020789
IGSF9

immunoglobulin superfamily, member 9

chr21_-_43670348 1.987 SIK1
salt-inducible kinase 1
chr2_-_73350103 1.970 NM_001080410
FBXO41
F-box protein 41
chr11_-_65895640 1.955 NM_001532
SLC29A2
solute carrier family 29 (nucleoside transporters), member 2
chr20_+_13150417 1.948 NM_080826
ISM1
isthmin 1 homolog (zebrafish)
chr18_+_59295123 1.921 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr17_+_35147738 1.897 GRB7
growth factor receptor-bound protein 7
chr1_-_159257486 1.894 F11R
F11 receptor
chr9_-_125070675 1.887 NM_001171137
STRBP
spermatid perinuclear RNA binding protein
chr18_+_58143499 1.877 NM_003839
TNFRSF11A
tumor necrosis factor receptor superfamily, member 11a, NFKB activator
chr1_-_159257567 1.869 F11R
F11 receptor
chr2_-_237080830 1.850 NM_024726
IQCA1
IQ motif containing with AAA domain 1
chr1_-_159257595 1.813 NM_016946
F11R
F11 receptor
chr11_-_431995 1.810 NM_001012302
ANO9
anoctamin 9
chr19_-_6718417 1.795 NM_005490
SH2D3A
SH2 domain containing 3A
chr1_+_24518501 1.763 NM_001195010
GRHL3
grainyhead-like 3 (Drosophila)
chr11_-_431956 1.762 ANO9
anoctamin 9
chr3_-_123223658 1.745 NM_175924
ILDR1
immunoglobulin-like domain containing receptor 1
chr1_+_24518398 1.739 NM_198173
NM_198174
GRHL3

grainyhead-like 3 (Drosophila)

chr17_-_6400470 1.730 NM_001165966
NM_031220
PITPNM3

PITPNM family member 3

chr14_-_60817663 1.725 TMEM30B
transmembrane protein 30B
chr11_+_45900731 1.716 GYLTL1B
glycosyltransferase-like 1B
chr1_-_58815415 1.715 TACSTD2
tumor-associated calcium signal transducer 2
chr9_-_125070613 1.678 NM_018387
STRBP
spermatid perinuclear RNA binding protein
chr4_+_155884600 1.674 NM_004744
LRAT
lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
chr8_+_144888275 1.665 LOC100128338
hypothetical LOC100128338
chr1_+_232416618 1.624 SLC35F3
solute carrier family 35, member F3
chr12_-_32940931 1.613 NM_001005242
NM_004572
PKP2

plakophilin 2

chr14_-_60817621 1.612


chr10_+_115988999 1.607 NM_198496
VWA2
von Willebrand factor A domain containing 2
chr2_-_36384 1.606 NM_001077710
FAM110C
family with sequence similarity 110, member C
chr14_-_60817709 1.565 TMEM30B
transmembrane protein 30B
chr19_-_40693176 1.559 NM_001126059
DMKN
dermokine
chr8_+_102574012 1.552 GRHL2
grainyhead-like 2 (Drosophila)
chr9_-_38610579 1.541 ANKRD18A
ankyrin repeat domain 18A
chr5_+_76150637 1.540 F2RL1
coagulation factor II (thrombin) receptor-like 1
chr17_+_32368611 1.532 NM_005568
LHX1
LIM homeobox 1
chr14_-_60817946 1.523


chr11_+_72607254 1.518 P2RY2
purinergic receptor P2Y, G-protein coupled, 2
chr1_-_58815753 1.510 NM_002353
TACSTD2
tumor-associated calcium signal transducer 2
chr7_+_149651202 1.510 NM_001142928
NM_023942
LRRC61

leucine rich repeat containing 61

chr17_+_35147697 1.506 NM_005310
GRB7
growth factor receptor-bound protein 7
chr16_+_67236699 1.484 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr16_-_14695930 1.458 NM_003561
PLA2G10
phospholipase A2, group X
chr1_+_3360880 1.449 NM_014448
ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr5_+_76150588 1.447 NM_005242
F2RL1
coagulation factor II (thrombin) receptor-like 1
chr19_+_43486640 1.446 NM_033520
C19orf33
chromosome 19 open reading frame 33
chr6_+_7486836 1.443 DSP
desmoplakin
chr8_+_95722575 1.438 ESRP1
epithelial splicing regulatory protein 1
chr7_-_97868101 1.436 BAIAP2L1
BAI1-associated protein 2-like 1
chr2_+_47449790 1.435 NM_002354
EPCAM
epithelial cell adhesion molecule
chr2_-_74522563 1.433 NM_001015055
RTKN
rhotekin
chr2_-_74522513 1.432 RTKN
rhotekin
chrX_+_130985316 1.431 NM_001042452
MST4
serine/threonine protein kinase MST4
chr20_-_17986520 1.427 NM_021220
OVOL2
ovo-like 2 (Drosophila)
chr1_+_12046020 1.427 NM_001243
TNFRSF8
tumor necrosis factor receptor superfamily, member 8
chr8_-_95720870 1.422 LOC100288748
hypothetical LOC100288748
chr7_+_29570024 1.414 PRR15
proline rich 15
chr17_-_35911340 1.409 NM_032865
TNS4
tensin 4
chr6_+_7486891 1.408 DSP
desmoplakin
chr6_+_7486862 1.396 NM_001008844
NM_004415
DSP

desmoplakin

chr1_+_199975563 1.393 NM_001167738
NAV1
neuron navigator 1
chr2_-_74522534 1.388 RTKN
rhotekin
chr1_-_55039458 1.366 NM_001114108
NM_017904
TTC22

tetratricopeptide repeat domain 22

chr14_-_70345485 1.365 NM_033141
MAP3K9
mitogen-activated protein kinase kinase kinase 9
chr11_+_75157414 1.359 NM_032564
DGAT2
diacylglycerol O-acyltransferase 2
chr11_+_75157450 1.350 DGAT2
diacylglycerol O-acyltransferase 2
chr11_+_72607040 1.349 NM_176071
P2RY2
purinergic receptor P2Y, G-protein coupled, 2
chr5_-_168660293 1.340 NM_003062
SLIT3
slit homolog 3 (Drosophila)
chr1_+_61980679 1.330 NM_176877
INADL
InaD-like (Drosophila)
chr8_+_95722516 1.322 NM_001034915
NM_001122825
NM_001122826
NM_001122827
NM_017697
ESRP1




epithelial splicing regulatory protein 1




chr2_+_47449951 1.312 EPCAM
epithelial cell adhesion molecule
chr1_+_11637448 1.296 NM_001014765
NM_033182
NM_183413
FBXO44


F-box protein 44


chr11_+_72606950 1.296 NM_002564
NM_176072
P2RY2

purinergic receptor P2Y, G-protein coupled, 2

chr7_+_29569978 1.291 PRR15
proline rich 15
chr18_+_45342398 1.280 NM_006033
LIPG
lipase, endothelial
chr19_+_49972965 1.273 NM_001130852
NM_012116
CBLC

Cas-Br-M (murine) ecotropic retroviral transforming sequence c

chr17_+_40681060 1.266 LOC100133991
similar to hCG1995169
chr18_+_42167904 1.266 RNF165
ring finger protein 165
chr19_-_56214765 1.262 NM_145888
KLK10
kallikrein-related peptidase 10
chr17_-_47590669 1.255 CA10
carbonic anhydrase X
chr22_-_49317408 1.249 ODF3B
outer dense fiber of sperm tails 3B
chr14_-_91372365 1.243 NM_001128595
NM_152332
TC2N

tandem C2 domains, nuclear

chr6_+_41714171 1.233 NM_005586
MDFI
MyoD family inhibitor
chr17_-_47591123 1.233 NM_020178
CA10
carbonic anhydrase X
chr3_-_12775718 1.228 NM_018306
TMEM40
transmembrane protein 40
chr5_+_68824143 1.224 OCLN
occludin
chr19_-_19599973 1.223 NM_004720
LPAR2
lysophosphatidic acid receptor 2
chr17_+_9489578 1.221 NM_153210
USP43
ubiquitin specific peptidase 43
chr9_-_139183675 1.213


chr19_-_10558906 1.209 NM_005498
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr15_-_50375143 1.185 NM_018728
MYO5C
myosin VC
chr1_+_36544549 1.180 NM_001162530
SH3D21
SH3 domain containing 21
chr14_-_20636337 1.173 ZNF219
zinc finger protein 219
chr2_+_17585462 1.164 VSNL1
visinin-like 1
chr5_-_138753443 1.159 NM_016459
MZB1
marginal zone B and B1 cell-specific protein
chr1_+_26376560 1.158 NM_006314
CNKSR1
connector enhancer of kinase suppressor of Ras 1
chr9_-_92444886 1.150 NM_017594
DIRAS2
DIRAS family, GTP-binding RAS-like 2
chr8_-_81246215 1.149 NM_001025253
NM_005079
TPD52

tumor protein D52

chr1_+_26376611 1.146 CNKSR1
connector enhancer of kinase suppressor of Ras 1
chr19_+_45811856 1.137 LTBP4
latent transforming growth factor beta binding protein 4
chr3_+_98016114 1.126 NM_001080448
EPHA6
EPH receptor A6
chr20_-_6051562 1.121 FERMT1
fermitin family member 1
chr9_-_6635564 1.115 NM_000170
GLDC
glycine dehydrogenase (decarboxylating)
chr2_-_216586488 1.112 NM_018000
MREG
melanoregulin
chr11_+_69602055 1.108 NM_018043
ANO1
anoctamin 1, calcium activated chloride channel
chr19_+_40299058 1.108 FXYD3
FXYD domain containing ion transport regulator 3
chr11_+_46323558 1.105 NM_201533
DGKZ
diacylglycerol kinase, zeta
chr1_+_181422016 1.105 LAMC2
laminin, gamma 2
chr15_+_38923914 1.102 NM_001032367
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr6_+_150505849 1.102 NM_030949
PPP1R14C
protein phosphatase 1, regulatory (inhibitor) subunit 14C
chr11_+_46323495 1.099 DGKZ
diacylglycerol kinase, zeta
chr17_+_35148084 1.093 NM_001030002
GRB7
growth factor receptor-bound protein 7
chr8_-_110726063 1.093 SYBU
syntabulin (syntaxin-interacting)
chr17_+_38064787 1.089 NM_016437
TUBG2
tubulin, gamma 2
chr18_+_11679135 1.088 NM_182978
GNAL
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr16_-_28542366 1.085 NM_177536
SULT1A1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr6_+_54819527 1.059 NM_001010872
FAM83B
family with sequence similarity 83, member B
chr9_+_140164359 1.043 TUBBP5
tubulin, beta pseudogene 5
chrX_+_152608159 1.042 NM_001142806
SLC6A8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr16_+_23101538 1.041 NM_001039
SCNN1G
sodium channel, nonvoltage-gated 1, gamma
chr6_-_63053811 1.038 NM_152688
KHDRBS2
KH domain containing, RNA binding, signal transduction associated 2
chr19_+_45811647 1.038 LTBP4
latent transforming growth factor beta binding protein 4
chr17_+_7883076 1.034 NM_001039130
NM_001039131
NM_001141
ALOX15B


arachidonate 15-lipoxygenase, type B


chr22_+_43527101 1.031 NM_001017526
NM_001198726
NM_181335
ARHGAP8


Rho GTPase activating protein 8


chr2_+_17585287 1.029 NM_003385
VSNL1
visinin-like 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.16 1.15e-02 GO:0023052 signaling
1.25 1.31e-02 GO:0023051 regulation of signaling

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.09 1.73e-04 GO:0005737 cytoplasm

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.12 8.87e-06 GO:0005515 protein binding
2.14 1.29e-02 GO:0005275 amine transmembrane transporter activity
2.08 1.84e-02 GO:0015294 solute:cation symporter activity
1.66 3.46e-02 GO:0015291 secondary active transmembrane transporter activity
1.49 4.30e-02 GO:0022804 active transmembrane transporter activity