Motif ID: FOXD3.p2

Z-value: 1.174


Transcription factors associated with FOXD3.p2:

Gene SymbolEntrez IDGene Name
FOXD3 27022 forkhead box D3



Activity profile for motif FOXD3.p2.

activity profile for motif FOXD3.p2


Sorted Z-values histogram for motif FOXD3.p2

Sorted Z-values for motif FOXD3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXD3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_138159396 2.302 NM_144717
IL20RB
interleukin 20 receptor beta
chr18_+_59405513 2.105 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr4_+_75393053 1.921 NM_001013442
EPGN
epithelial mitogen homolog (mouse)
chr20_+_19863716 1.877 RIN2
Ras and Rab interactor 2
chr13_-_40491491 1.672 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr18_+_27281729 1.640 NM_001944
DSG3
desmoglein 3
chr13_-_40491405 1.539 ELF1
E74-like factor 1 (ets domain transcription factor)
chr10_+_118177371 1.479 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chr19_+_57564981 1.438 NM_001145434
ZNF880
zinc finger protein 880
chr21_+_38550739 1.395 NM_170736
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr3_+_11242666 1.344 NM_001098211
HRH1
histamine receptor H1
chr9_-_116608113 1.310 NM_005118
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
chr4_-_90978469 1.233 NM_001146055
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr13_-_85271329 1.221 NM_032229
SLITRK6
SLIT and NTRK-like family, member 6
chr22_+_43527101 1.214 NM_001017526
NM_001198726
NM_181335
ARHGAP8


Rho GTPase activating protein 8


chr3_+_190990142 1.200 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr4_+_167013859 1.181 NM_012464
TLL1
tolloid-like 1
chr7_-_87687276 1.161 SRI
sorcin
chr6_+_150304813 1.134 NM_025217
ULBP2
UL16 binding protein 2
chr3_+_133798770 1.125 NM_016557
CCRL1
chemokine (C-C motif) receptor-like 1
chr12_+_46799279 1.117 NM_000289
PFKM
phosphofructokinase, muscle
chr1_-_159275334 1.113 TSTD1
thiosulfate sulfurtransferase (rhodanese)-like domain containing 1
chr19_-_51319769 1.095 NM_207393
IGFL3
IGF-like family member 3
chr22_+_36008511 1.084 CYTH4
cytohesin 4
chrX_-_138552517 1.080 NM_001171877
NM_001171878
NM_001171879
NM_005369
MCF2



MCF.2 cell line derived transforming sequence



chr3_-_12561962 1.078 NM_001195279
LOC100129480
hypothetical protein LOC100129480
chr14_-_98807307 1.058 BCL11B
B-cell CLL/lymphoma 11B (zinc finger protein)
chr4_-_153523113 1.036 NM_001013415
FBXW7
F-box and WD repeat domain containing 7
chr22_+_36008465 0.995 CYTH4
cytohesin 4
chr15_+_56217686 0.949 NM_020980
AQP9
aquaporin 9
chr3_+_195336625 0.943 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr2_-_160765008 0.942 ITGB6
integrin, beta 6
chr5_-_43432969 0.921 CCL28
chemokine (C-C motif) ligand 28
chr16_+_80370400 0.897 PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr4_-_38710376 0.896 NM_024943
TMEM156
transmembrane protein 156
chr6_+_121798443 0.891 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr19_+_6415259 0.885 NM_139161
NM_174881
CRB3

crumbs homolog 3 (Drosophila)

chrX_-_23955223 0.879 NM_030624
KLHL15
kelch-like 15 (Drosophila)
chr1_-_159275357 0.872 NM_001113205
NM_001113206
NM_001113207
TSTD1


F11R
thiosulfate sulfurtransferase (rhodanese)-like domain containing 1


F11 receptor
chr7_-_16471817 0.871 NM_015464
SOSTDC1
sclerostin domain containing 1
chr2_-_218739891 0.864 NM_000634
CXCR1
chemokine (C-X-C motif) receptor 1
chr22_+_36008369 0.846 NM_013385
CYTH4
cytohesin 4
chr4_+_100957003 0.844 NM_014395
DAPP1
dual adaptor of phosphotyrosine and 3-phosphoinositides
chr1_+_181421796 0.832 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr1_+_13784553 0.809 NM_001006624
NM_001006625
PDPN

podoplanin

chr5_+_159368690 0.802 TTC1
tetratricopeptide repeat domain 1
chr11_-_128399218 0.795 NM_014715
ARHGAP32
Rho GTPase activating protein 32
chr2_-_215711313 0.789 NM_173076
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr6_-_137536412 0.787 NM_052962
NM_181309
NM_181310
IL22RA2


interleukin 22 receptor, alpha 2


chr5_+_159368733 0.785 NM_003314
TTC1
tetratricopeptide repeat domain 1
chr1_-_100003936 0.775 NM_001013660
FRRS1
ferric-chelate reductase 1
chr6_+_49626071 0.768 NM_001145652
C6orf141
chromosome 6 open reading frame 141
chr7_-_112513379 0.762 NM_001146266
NM_001146267
GPR85

G protein-coupled receptor 85

chr7_-_87687302 0.756 NM_003130
SRI
sorcin
chr7_+_151284396 0.746 NM_145292
GALNTL5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5
chr1_+_81544432 0.738 LPHN2
latrophilin 2
chr2_+_165858586 0.724 NM_021007
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr13_-_83354474 0.711 NM_052910
SLITRK1
SLIT and NTRK-like family, member 1
chr8_-_42742729 0.703 NM_004198
CHRNA6
cholinergic receptor, nicotinic, alpha 6
chr15_+_76345577 0.703 NM_001130183
DNAJA4
DnaJ (Hsp40) homolog, subfamily A, member 4
chr10_-_98021144 0.697 NM_001114094
NM_013314
BLNK

B-cell linker

chr17_+_7883076 0.691 NM_001039130
NM_001039131
NM_001141
ALOX15B


arachidonate 15-lipoxygenase, type B


chr8_-_108579270 0.683 NM_001146
ANGPT1
angiopoietin 1
chr13_-_83354425 0.682 SLITRK1
SLIT and NTRK-like family, member 1
chr3_-_184756101 0.677 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr10_+_47875229 0.676 NM_001040084
NM_001098845
ANXA8L2
ANXA8
ANXA8L1
annexin A8-like 2
annexin A8
annexin A8-like 1
chr2_+_237143118 0.676 NM_020311
CXCR7
chemokine (C-X-C motif) receptor 7
chr3_+_123256902 0.672 NM_175862
CD86
CD86 molecule
chr5_-_94442941 0.671 MCTP1
multiple C2 domains, transmembrane 1
chr13_-_98708549 0.666 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr1_-_27825178 0.652 NM_001042747
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chr10_+_47216925 0.652 NM_001630
ANXA8L2
ANXA8
annexin A8-like 2
annexin A8
chr2_-_72228427 0.648 NM_019885
CYP26B1
cytochrome P450, family 26, subfamily B, polypeptide 1
chr19_-_4289750 0.645 NM_001013841
NM_017720
STAP2

signal transducing adaptor family member 2

chr1_+_13782838 0.643 NM_006474
NM_198389
PDPN

podoplanin

chr16_+_67235651 0.643 NM_001793
CDH3
cadherin 3, type 1, P-cadherin (placental)
chr10_-_46593923 0.636 NM_001040084
NM_001098845
ANXA8L2
LOC653110
ANXA8
ANXA8L1
annexin A8-like 2
hypothetical LOC653110
annexin A8
annexin A8-like 1
chr3_+_108578877 0.634 NM_032600
CCDC54
coiled-coil domain containing 54
chr22_+_44828338 0.627


chr5_+_40877053 0.627 NM_032587
CARD6
caspase recruitment domain family, member 6
chr1_+_218768170 0.625 NM_018650
MARK1
MAP/microtubule affinity-regulating kinase 1
chr17_-_26665213 0.610 EVI2B
ecotropic viral integration site 2B
chr12_-_15005761 0.604 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr10_+_71231693 0.603 COL13A1
collagen, type XIII, alpha 1
chr18_+_27152049 0.603 NM_001942
DSG1
desmoglein 1
chr1_+_190811479 0.596 NM_002922
RGS1
regulator of G-protein signaling 1
chr20_+_51023159 0.595 TSHZ2
teashirt zinc finger homeobox 2
chr1_-_77457664 0.595 NM_005482
PIGK
phosphatidylinositol glycan anchor biosynthesis, class K
chr1_-_158948176 0.593 NM_001778
CD48
CD48 molecule
chr17_-_26665194 0.592 EVI2B
ecotropic viral integration site 2B
chr5_+_159368721 0.581 TTC1
tetratricopeptide repeat domain 1
chr1_+_179719338 0.578 NM_000721
CACNA1E
calcium channel, voltage-dependent, R type, alpha 1E subunit
chr12_+_55201854 0.575 NM_002898
RBMS2
RNA binding motif, single stranded interacting protein 2
chr5_-_59100194 0.573 NM_001197218
PDE4D
phosphodiesterase 4D, cAMP-specific
chr12_+_27066749 0.571 NM_004264
MED21
mediator complex subunit 21
chr17_-_26665144 0.569 EVI2B
ecotropic viral integration site 2B
chr19_-_4782711 0.568 NM_182919
TICAM1
toll-like receptor adaptor molecule 1
chr17_-_26665220 0.564 NM_006495
EVI2B
ecotropic viral integration site 2B
chr14_-_60817946 0.562


chr12_+_27066768 0.558 MED21
mediator complex subunit 21
chr21_+_38550533 0.557 NM_002243
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr3_+_195336631 0.540 HES1
hairy and enhancer of split 1, (Drosophila)
chr12_-_83954185 0.539 NM_001100917
TSPAN19
tetraspanin 19
chr2_-_160764819 0.531 NM_000888
ITGB6
integrin, beta 6
chr7_-_92615593 0.531 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr3_-_191321367 0.531 LEPREL1
leprecan-like 1
chr6_+_31190505 0.527 NM_014068
PSORS1C1
psoriasis susceptibility 1 candidate 1
chr15_-_58477407 0.526 NM_001002857
NM_001002858
NM_001136015
NM_004039
ANXA2



annexin A2



chr17_-_8364942 0.525 MYH10
myosin, heavy chain 10, non-muscle
chr19_+_42689881 0.524 ZNF793
zinc finger protein 793
chr19_-_56946911 0.524 NM_001193306
NM_002029
FPR1

formyl peptide receptor 1

chr18_-_33399601 0.523 CELF4
CUGBP, Elav-like family member 4
chr21_-_41140457 0.520 DSCAM
Down syndrome cell adhesion molecule
chr12_+_29193399 0.517 FAR2
fatty acyl CoA reductase 2
chr14_-_60818263 0.512 NM_001017970
TMEM30B
transmembrane protein 30B
chr10_+_71231649 0.511 NM_001130103
NM_080798
NM_080800
NM_080801
NM_080802
NM_080805
COL13A1





collagen, type XIII, alpha 1





chr2_+_201182187 0.510 AOX1
aldehyde oxidase 1
chr2_-_158008763 0.510 NM_004288
CYTIP
cytohesin 1 interacting protein
chr19_-_11550765 0.504 NM_001111035
NM_001111036
ACP5

acid phosphatase 5, tartrate resistant

chr19_+_3087026 0.486 NM_002068
GNA15
guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
chr3_+_123385219 0.485 NM_000388
CASR
calcium-sensing receptor
chr2_-_213723298 0.484 NM_016260
IKZF2
IKAROS family zinc finger 2 (Helios)
chr2_-_108972048 0.481 EDAR
ectodysplasin A receptor
chr1_+_218768146 0.474 MARK1
MAP/microtubule affinity-regulating kinase 1
chr19_-_10558906 0.473 NM_005498
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr19_-_19793512 0.472 NM_001099269
NM_001145404
ZNF506

zinc finger protein 506

chr7_-_20223467 0.466 NM_182762
MACC1
metastasis associated in colon cancer 1
chr10_-_116241572 0.461


chr21_-_38792173 0.458 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr22_-_23500682 0.454 NM_001008496
PIWIL3
piwi-like 3 (Drosophila)
chr14_-_80475636 0.454 NM_152446
C14orf145
chromosome 14 open reading frame 145
chr3_+_123779122 0.452 NM_001113523
PARP15
poly (ADP-ribose) polymerase family, member 15
chr11_-_26550243 0.452 NM_001135091
NM_001135092
NM_145650
MUC15


mucin 15, cell surface associated


chr1_-_21373816 0.450 NM_001198803
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr17_-_53847937 0.450 RNF43
ring finger protein 43
chr2_+_102320148 0.446 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr3_+_123526700 0.445 NM_005213
CSTA
cystatin A (stefin A)
chr19_+_59820413 0.444 NM_006669
LILRB1
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
chr19_+_45973139 0.439 NM_006533
MIA
melanoma inhibitory activity
chr3_-_112796855 0.435 NM_024508
ZBED2
zinc finger, BED-type containing 2
chr1_+_34993234 0.434 NM_005268
GJB5
gap junction protein, beta 5, 31.1kDa
chr3_+_29297806 0.433 NM_001003792
NM_001003793
NM_001177711
NM_001177712
NM_014483
RBMS3




RNA binding motif, single stranded interacting protein 3




chr5_+_96237923 0.433 ERAP2
endoplasmic reticulum aminopeptidase 2
chr6_+_26348539 0.432 NM_003540
HIST1H4F
histone cluster 1, H4f
chr2_-_85490997 0.432 NM_001747
CAPG
capping protein (actin filament), gelsolin-like
chr9_-_25668230 0.431 TUSC1
tumor suppressor candidate 1
chr1_+_107485071 0.430 NTNG1
netrin G1
chr14_+_101345878 0.428 NM_002719
NM_178586
NM_178587
PPP2R5C


protein phosphatase 2, regulatory subunit B', gamma


chr12_+_21175394 0.428 NM_006446
SLCO1B1
solute carrier organic anion transporter family, member 1B1
chr19_+_48772791 0.424 NM_001193621
LOC390940
hypothetical protein LOC390940
chr21_+_29439768 0.423 C21orf7
chromosome 21 open reading frame 7
chr6_-_32892705 0.423 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr2_-_108972100 0.422 NM_022336
EDAR
ectodysplasin A receptor
chr1_+_84540921 0.421 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chr1_+_104093962 0.415 NM_004038
NM_001008218
NM_001008219
AMY1A
AMY1B
AMY1C
amylase, alpha 1A (salivary)
amylase, alpha 1B (salivary)
amylase, alpha 1C (salivary)
chr1_+_158975662 0.410 NM_021181
SLAMF7
SLAM family member 7
chrX_-_101297417 0.406 NM_001159560
NM_001012978
BEX5

brain expressed, X-linked 5

chr9_+_676640 0.404


chr12_+_77782579 0.404 NM_005639
SYT1
synaptotagmin I
chr1_-_221920023 0.401 NM_001143962
CAPN8
calpain 8
chr9_-_87904844 0.401 NM_177937
GOLM1
golgi membrane protein 1
chr4_-_153820535 0.399 NM_152680
TMEM154
transmembrane protein 154
chr3_-_188339882 0.397 NM_052969
RPL39L
ribosomal protein L39-like
chr4_-_38534802 0.397 NM_006068
TLR6
toll-like receptor 6
chr3_+_137224266 0.395 NM_181897
PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chr5_-_24680841 0.393 NM_006727
CDH10
cadherin 10, type 2 (T2-cadherin)
chr7_-_102070473 0.390 NM_001114403
UPK3BL
POLR2J2
uroplakin 3B-like
polymerase (RNA) II (DNA directed) polypeptide J2
chr19_+_42689680 0.386 NM_001013659
ZNF793
zinc finger protein 793
chr11_+_112763722 0.385 NM_178510
ANKK1
ankyrin repeat and kinase domain containing 1
chr12_+_52708460 0.380 NM_004503
HOXC6
homeobox C6
chr1_-_177378801 0.377 NM_001136000
NM_001168239
NM_005158
ABL2


v-abl Abelson murine leukemia viral oncogene homolog 2


chr12_+_52696908 0.377 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr1_-_158759606 0.374 NM_001184714
NM_001184715
NM_001184716
NM_052931
SLAMF6



SLAM family member 6



chr10_-_116276560 0.373 ABLIM1
actin binding LIM protein 1
chr7_+_28692122 0.370 NM_001011666
CREB5
cAMP responsive element binding protein 5
chr7_-_83116414 0.369 NM_012431
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr18_+_59705918 0.367 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr1_-_221919982 0.366 CAPN8
calpain 8
chr9_+_27514311 0.366 NM_020124
IFNK
interferon, kappa
chr2_-_121759237 0.365 NM_014553
TFCP2L1
transcription factor CP2-like 1
chr5_+_176717449 0.359 NM_006480
RGS14
regulator of G-protein signaling 14
chr4_+_75449720 0.359 NM_001432
EREG
epiregulin
chr13_-_74799898 0.359 TBC1D4
TBC1 domain family, member 4
chr9_+_74956601 0.355 ANXA1
annexin A1
chr11_+_67107852 0.353 GSTP1
glutathione S-transferase pi 1
chr3_-_15814678 0.352 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr3_+_179736917 0.352 NM_181361
KCNMB2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr16_-_28542366 0.348 NM_177536
SULT1A1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr3_-_170346760 0.348 NM_001105077
NM_001163999
NM_005241
MECOM


MDS1 and EVI1 complex locus


chrX_+_11221453 0.346 NM_001142
NM_182680
NM_182681
AMELX


amelogenin, X-linked


chr5_+_36644187 0.346 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_-_43458247 0.345 NM_001482
GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr9_+_126460511 0.344


chr9_+_5500544 0.341 NM_025239
PDCD1LG2
programmed cell death 1 ligand 2
chr19_-_55539769 0.341 NAPSB
napsin B aspartic peptidase pseudogene
chr12_-_28016182 0.338 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr11_-_107969554 0.335 NM_015065
EXPH5
exophilin 5
chr5_-_58607673 0.335 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr17_-_36719030 0.335 NM_001146182
KRTAP16-1
keratin associated protein 16-1
chr3_+_100840129 0.333 NM_001850
NM_020351
COL8A1

collagen, type VIII, alpha 1


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.61 5.45e-03 GO:0007608 sensory perception of smell
1.33 1.04e-02 GO:0002376 immune system process
1.55 1.32e-02 GO:0007606 sensory perception of chemical stimulus
1.75 2.56e-02 GO:0045321 leukocyte activation
1.11 3.46e-02 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.15 2.87e-03 GO:0071944 cell periphery
1.15 3.13e-03 GO:0005886 plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.31 1.12e-04 GO:0004872 receptor activity
1.26 4.25e-04 GO:0004871 signal transducer activity
1.26 4.25e-04 GO:0060089 molecular transducer activity
1.65 5.78e-04 GO:0004984 olfactory receptor activity
3.07 3.44e-03 GO:0003823 antigen binding
1.31 3.91e-03 GO:0004888 transmembrane receptor activity
1.36 1.77e-02 GO:0004930 G-protein coupled receptor activity