Motif ID: MSX1,2.p2

Z-value: 2.738


Transcription factors associated with MSX1,2.p2:

Gene SymbolEntrez IDGene Name
MSX1 4487 msh homeobox 1
MSX2 4488 msh homeobox 2



Activity profile for motif MSX1,2.p2.

activity profile for motif MSX1,2.p2


Sorted Z-values histogram for motif MSX1,2.p2

Sorted Z-values for motif MSX1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MSX1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_115880372 6.335 AMBP
alpha-1-microglobulin/bikunin precursor
chr10_-_74384569 5.718 PLA2G12B
phospholipase A2, group XIIB
chr21_-_36774257 5.680 NM_001146079
NM_144492
CLDN14

claudin 14

chr10_-_74384485 5.645 NM_032562
PLA2G12B
phospholipase A2, group XIIB
chr2_-_180135559 5.100 NM_001113398
ZNF385B
zinc finger protein 385B
chr9_-_115880281 4.646 AMBP
alpha-1-microglobulin/bikunin precursor
chr10_+_7785360 4.181 ITIH2
inter-alpha (globulin) inhibitor H2
chr12_+_70119785 4.133 LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr9_-_126309510 4.116 NM_004959
NR5A1
nuclear receptor subfamily 5, group A, member 1
chr9_-_115880425 4.097 AMBP
alpha-1-microglobulin/bikunin precursor
chr2_-_192420168 4.016 NM_004657
SDPR
serum deprivation response
chr3_-_150422474 3.825 NM_000096
CP
ceruloplasmin (ferroxidase)
chr11_-_85074848 3.716 NM_152723
CCDC89
coiled-coil domain containing 89
chrX_+_115481774 3.539 NM_007231
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr10_+_7785331 3.525 ITIH2
inter-alpha (globulin) inhibitor H2
chr3_+_25445071 3.373 RARB
retinoic acid receptor, beta
chr19_-_40696393 3.137 NM_001126056
NM_001126057
NM_001126058
NM_001190347
NM_001190348
NM_001190349
NM_033317
DMKN






dermokine






chr2_-_237987554 2.892 COL6A3
collagen, type VI, alpha 3
chr3_+_52803823 2.887 NM_002217
ITIH3
inter-alpha (globulin) inhibitor H3
chr2_-_237987553 2.853 COL6A3
collagen, type VI, alpha 3
chr2_-_237987579 2.778 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chr4_+_89115862 2.756 SPP1
secreted phosphoprotein 1
chr2_-_237987545 2.729 COL6A3
collagen, type VI, alpha 3
chr2_-_192419896 2.689 SDPR
serum deprivation response
chr4_-_159311959 2.687 FAM198B
family with sequence similarity 198, member B
chr14_-_93324518 2.604 NM_178013
PRIMA1
proline rich membrane anchor 1
chr14_-_64479198 2.576 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr4_+_89115825 2.507 NM_000582
NM_001040058
NM_001040060
SPP1


secreted phosphoprotein 1


chr12_+_52105131 2.506 AMHR2
anti-Mullerian hormone receptor, type II
chr2_-_237987509 2.395 COL6A3
collagen, type VI, alpha 3
chrX_+_115481848 2.331 SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr16_-_29817841 2.317 NM_001114099
NM_001114100
NM_012410
NM_201575
SEZ6L2



seizure related 6 homolog (mouse)-like 2



chr1_+_200246370 2.309 ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr4_+_89115892 2.291 SPP1
secreted phosphoprotein 1
chr3_+_25444753 2.256 NM_016152
RARB
retinoic acid receptor, beta
chr9_-_115880366 2.239 AMBP
alpha-1-microglobulin/bikunin precursor
chr8_-_145613058 2.195 NM_130849
SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr16_-_11918019 2.149 NM_001130007
GSPT1
G1 to S phase transition 1
chr8_-_145613034 2.079 SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr10_+_7785347 1.999 ITIH2
inter-alpha (globulin) inhibitor H2
chr3_+_25444837 1.924 NM_000965
RARB
retinoic acid receptor, beta
chr7_-_96471544 1.908 DLX6-AS1
DLX6 antisense RNA 1 (non-protein coding)
chr5_-_148738980 1.906 NM_014443
IL17B
interleukin 17B
chr3_-_150578148 1.847 TM4SF1
transmembrane 4 L six family member 1
chr4_+_155703581 1.833 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr20_-_48686832 1.831 NM_080829
FAM65C
family with sequence similarity 65, member C
chr5_+_59819761 1.801 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr12_+_108038774 1.726 ACACB
acetyl-CoA carboxylase beta
chr10_+_7785290 1.697 ITIH2
inter-alpha (globulin) inhibitor H2
chr1_-_108032645 1.695 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr3_+_129690735 1.691


chr6_-_52060327 1.577 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr3_-_150578207 1.533 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr4_+_89115923 1.504 SPP1
secreted phosphoprotein 1
chr17_-_61655915 1.491 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr19_-_17236522 1.409 NM_031941
USHBP1
Usher syndrome 1C binding protein 1
chr5_-_22248630 1.399 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr10_-_44794146 1.360 NM_007021
C10orf10
chromosome 10 open reading frame 10
chr8_-_38127489 1.338 NM_000349
STAR
steroidogenic acute regulatory protein
chr2_-_165133239 1.334 GRB14
growth factor receptor-bound protein 14
chr12_-_69837831 1.322 TSPAN8
tetraspanin 8
chr22_+_33792125 1.313 NM_001008494
ISX
intestine-specific homeobox
chr12_+_56114724 1.285 NM_005538
INHBC
inhibin, beta C
chr12_-_6354818 1.265 SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr7_+_116238309 1.197 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr12_+_7039453 1.151


chr6_+_16237264 1.146 NM_013262
MYLIP
myosin regulatory light chain interacting protein
chr5_+_140509803 1.118 NM_018939
PCDHB6
protocadherin beta 6
chr8_-_15140162 1.118 NM_139167
SGCZ
sarcoglycan, zeta
chr3_+_9919295 1.109 NM_153483
IL17RE
interleukin 17 receptor E
chr16_+_55042924 1.105 NM_018233
OGFOD1
2-oxoglutarate and iron-dependent oxygenase domain containing 1
chr21_+_44729875 1.066


chr16_+_55042936 1.054 OGFOD1
2-oxoglutarate and iron-dependent oxygenase domain containing 1
chr4_+_71096830 1.048 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr10_+_685887 1.042 C10orf108
chromosome 10 open reading frame 108
chr3_-_121884091 1.034 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr4_-_155753332 1.015 NM_000509
NM_021870
FGG

fibrinogen gamma chain

chr3_-_121883647 1.013 HGD
homogentisate 1,2-dioxygenase
chr9_-_96395828 1.002 NM_003837
FBP2
fructose-1,6-bisphosphatase 2
chr7_+_94377145 0.994 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory (inhibitor) subunit 9A


chr14_-_106282128 0.965 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr16_-_67943157 0.948 NM_144676
TMED6
transmembrane emp24 protein transport domain containing 6
chr12_+_32546243 0.934 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr1_+_200246312 0.934 NM_001114309
NM_004433
ELF3

E74-like factor 3 (ets domain transcription factor, epithelial-specific )

chr2_+_138438277 0.933 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr3_+_9919511 0.931 NM_001193380
NM_153480
IL17RE

interleukin 17 receptor E

chr13_-_45577144 0.927 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr9_-_115880494 0.920 NM_001633
AMBP
alpha-1-microglobulin/bikunin precursor
chr2_-_77602843 0.918 NM_001134745
NM_024993
LRRTM4

leucine rich repeat transmembrane neuronal 4

chr3_-_127810087 0.895 NM_001039783
TXNRD3IT1
thioredoxin reductase 3 intronic transcript 1
chr4_-_39199527 0.891 UGDH
UDP-glucose 6-dehydrogenase
chr5_+_176726918 0.883 RGS14
regulator of G-protein signaling 14
chr16_-_21197072 0.873 CRYM
crystallin, mu
chr1_-_188713324 0.850 NM_199051
FAM5C
family with sequence similarity 5, member C
chrX_-_24600661 0.846 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr2_-_162638174 0.846 DPP4
dipeptidyl-peptidase 4
chr3_-_150578023 0.842 TM4SF1
transmembrane 4 L six family member 1
chr6_+_64289585 0.813 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr16_+_80626459 0.809 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr16_+_80626402 0.808 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chrX_+_128966844 0.805 NM_021946
BCORL1
BCL6 corepressor-like 1
chr6_-_48186868 0.805 C6orf138
chromosome 6 open reading frame 138
chr2_+_233633348 0.798 INPP5D
inositol polyphosphate-5-phosphatase, 145kDa
chr17_-_19592178 0.792 NM_000691
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr7_+_111850367 0.788 NM_001007245
NM_001197080
IFRD1

interferon-related developmental regulator 1

chr10_+_7785235 0.780 NM_002216
ITIH2
inter-alpha (globulin) inhibitor H2
chr14_+_22375632 0.780 NM_004995
MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr9_+_130942029 0.773 PPP2R4
protein phosphatase 2A activator, regulatory subunit 4
chrX_-_15530112 0.772 NM_021804
ACE2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr12_-_15757114 0.770 EPS8
epidermal growth factor receptor pathway substrate 8
chr3_-_150578103 0.770 TM4SF1
transmembrane 4 L six family member 1
chr12_+_49605010 0.768 METTL7A
methyltransferase like 7A
chr16_+_80626456 0.740 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr16_-_74056083 0.740 NM_145254
TMEM170A
transmembrane protein 170A
chr1_-_149245503 0.738 NM_001163259
NM_001163260
NM_001040217
FAM63A


family with sequence similarity 63, member A


chr1_+_54132447 0.726 NM_000792
NM_001039715
NM_001039716
NM_213593
DIO1



deiodinase, iodothyronine, type I



chr10_-_51678318 0.701 NM_001143974
NM_019893
ASAH2

N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2

chr1_+_31654998 0.701 NM_001199038
SERINC2
serine incorporator 2
chr6_+_16237300 0.698 MYLIP
myosin regulatory light chain interacting protein
chr5_-_42847716 0.691 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr19_-_14030970 0.672 NM_001145028
PALM3
paralemmin 3
chr6_-_123999640 0.655 NM_006073
TRDN
triadin
chr16_-_55042614 0.653 NM_007006
NUDT21
nudix (nucleoside diphosphate linked moiety X)-type motif 21
chr11_+_101488380 0.640 NM_001195045
YAP1
Yes-associated protein 1
chr17_+_38306339 0.636 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr6_-_39801088 0.619 NM_145027
KIF6
kinesin family member 6
chr7_+_80145461 0.613 CD36
CD36 molecule (thrombospondin receptor)
chr15_-_64644758 0.604 NM_207338
LCTL
lactase-like
chr2_+_84597087 0.588 NM_001370
DNAH6
dynein, axonemal, heavy chain 6
chr4_-_186970366 0.586 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr10_+_114123828 0.585 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr13_+_51496679 0.571 NM_021645
ALG11
UTP14C
asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast)
UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)
chr6_-_24491498 0.567 NM_001195610
DCDC2
doublecortin domain containing 2
chr1_+_31655607 0.559 NM_001199037
SERINC2
serine incorporator 2
chr4_+_71330797 0.558 NM_001145006
MUC7
mucin 7, secreted
chr20_+_71230 0.551 NM_030931
DEFB126
defensin, beta 126
chr1_-_229071957 0.548 NM_001136494
C1orf198
chromosome 1 open reading frame 198
chr17_-_15109315 0.532 NM_000304
PMP22
peripheral myelin protein 22
chr2_+_216695062 0.531 XRCC5
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
chr2_-_21087435 0.530 APOB
apolipoprotein B (including Ag(x) antigen)
chr14_+_20595820 0.530 NM_138331
RNASE8
ribonuclease, RNase A family, 8
chr12_-_110410730 0.527 ATXN2
ataxin 2
chr7_+_80069439 0.526 NM_001001547
CD36
CD36 molecule (thrombospondin receptor)
chr2_-_104834344 0.506 LOC100506421
hypothetical LOC100506421
chr8_-_27171814 0.499 NM_030795
STMN4
stathmin-like 4
chr11_-_40272239 0.497 NM_020929
LRRC4C
leucine rich repeat containing 4C
chr9_+_134843918 0.490 NM_001135031
NM_004188
GFI1B

growth factor independent 1B transcription repressor

chr6_+_154373323 0.484 NM_001145279
NM_001145280
NM_001145281
OPRM1


opioid receptor, mu 1


chr2_+_162908828 0.478 NM_012198
GCA
grancalcin, EF-hand calcium binding protein
chr11_-_8789457 0.475 NM_139157
ST5
suppression of tumorigenicity 5
chr12_-_6354650 0.474 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr12_-_89922888 0.466 NM_004950
EPYC
epiphycan
chr6_-_55848346 0.459 BMP5
bone morphogenetic protein 5
chr6_-_76022565 0.450 TMEM30A
transmembrane protein 30A
chr2_+_228064531 0.444 AGFG1
ArfGAP with FG repeats 1
chr7_+_17349425 0.433 AHR
aryl hydrocarbon receptor
chr6_-_31789824 0.432


chrX_+_54963953 0.430 NM_001039705
NM_016157
NM_177556
TRO


trophinin


chr3_-_167037946 0.412 NM_000055
BCHE
butyrylcholinesterase
chrX_+_99726445 0.408 NM_022144
TNMD
tenomodulin
chr17_+_4795128 0.405 NM_001193503
NM_001976
NM_053013
ENO3


enolase 3 (beta, muscle)


chr12_-_9252227 0.401 NM_002864
PZP
pregnancy-zone protein
chr3_+_46591048 0.400 NM_001174136
TDGF1
teratocarcinoma-derived growth factor 1
chr12_-_89922875 0.398 EPYC
epiphycan
chr20_+_31613800 0.391 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr2_-_210726539 0.388 C2orf67
chromosome 2 open reading frame 67
chr11_+_61473931 0.371 NM_001139443
NM_004183
BEST1

bestrophin 1

chr2_-_183095308 0.371 NM_005019
NM_001003683
PDE1A

phosphodiesterase 1A, calmodulin-dependent

chr1_-_19089971 0.369 NM_001161504
ALDH4A1
aldehyde dehydrogenase 4 family, member A1
chr5_-_59819642 0.369 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr21_+_39117064 0.359 ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr4_-_68793928 0.356 NM_182502
TMPRSS11B
transmembrane protease, serine 11B
chr1_-_200182090 0.355 LMOD1
leiomodin 1 (smooth muscle)
chr8_+_67096344 0.352 NM_033105
DNAJC5B
DnaJ (Hsp40) homolog, subfamily C, member 5 beta
chr6_-_49862858 0.349 NM_138733
PGK2
phosphoglycerate kinase 2
chr14_-_23752875 0.337 NM_014169
CHMP4A
chromatin modifying protein 4A
chr4_-_89963177 0.333 NM_001015045
FAM13A
family with sequence similarity 13, member A
chrX_+_28515479 0.329 NM_014271
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr14_-_23653965 0.325 NRL
neural retina leucine zipper
chr14_+_22375656 0.319 MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr6_-_31215089 0.307 NM_014069
PSORS1C2
psoriasis susceptibility 1 candidate 2
chr17_-_30909219 0.303 NM_001129820
SLFN14
schlafen family member 14
chr5_-_35083996 0.302 NM_031900
AGXT2
alanine--glyoxylate aminotransferase 2
chr13_+_57103789 0.300 NM_001040429
PCDH17
protocadherin 17
chr5_+_73145098 0.297 RGNEF
190 kDa guanine nucleotide exchange factor
chr2_-_21081694 0.297 APOB
apolipoprotein B (including Ag(x) antigen)
chr10_+_94823636 0.296 NM_000783
CYP26A1
cytochrome P450, family 26, subfamily A, polypeptide 1
chr9_-_85773899 0.292 HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr2_-_51112743 0.292 NRXN1
neurexin 1
chr9_+_1040367 0.287 DMRT2
doublesex and mab-3 related transcription factor 2
chr2_-_215957927 0.284 FN1
fibronectin 1
chr17_+_39213328 0.282 NM_001136483
C17orf105
chromosome 17 open reading frame 105
chr4_+_114190233 0.281 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr17_+_67628763 0.281 SOX9
SRY (sex determining region Y)-box 9
chr6_-_130578110 0.280 NM_152552
SAMD3
sterile alpha motif domain containing 3
chr6_-_31938572 0.279 NM_000434
NEU1
sialidase 1 (lysosomal sialidase)
chr17_-_36113502 0.274 NM_019016
KRT24
keratin 24
chr4_-_176970372 0.274 GPM6A
glycoprotein M6A
chr1_+_162795328 0.273 NM_002585
PBX1
pre-B-cell leukemia homeobox 1
chr6_-_26038817 0.271 NM_005835
SLC17A2
solute carrier family 17 (sodium phosphate), member 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.42 9.02e-03 GO:0032501 multicellular organismal process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.43 3.96e-04 GO:0005626 insoluble fraction
2.29 3.85e-03 GO:0005624 membrane fraction
2.07 4.09e-03 GO:0000267 cell fraction
1.70 8.52e-03 GO:0005576 extracellular region
1.42 2.14e-02 GO:0071944 cell periphery
24.24 4.08e-02 GO:0005577 fibrinogen complex

Nothing significant found in function category.