Motif ID: NKX2-3_NKX2-5.p2

Z-value: 1.124


Transcription factors associated with NKX2-3_NKX2-5.p2:

Gene SymbolEntrez IDGene Name
NKX2-3 159296 NK2 transcription factor related, locus 3 (Drosophila)
NKX2-5 1482 NK2 transcription factor related, locus 5 (Drosophila)



Activity profile for motif NKX2-3_NKX2-5.p2.

activity profile for motif NKX2-3_NKX2-5.p2


Sorted Z-values histogram for motif NKX2-3_NKX2-5.p2

Sorted Z-values for motif NKX2-3_NKX2-5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-3_NKX2-5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_53849888 2.329 RNF43
ring finger protein 43
chr2_+_171280046 1.789 NM_001003845
SP5
Sp5 transcription factor
chr9_-_116305273 1.623 NM_001083885
DFNB31
deafness, autosomal recessive 31
chrX_+_70682204 1.589 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr2_+_171280182 1.554


chr3_-_152517204 1.525 NM_023915
GPR87
G protein-coupled receptor 87
chr10_-_123346148 1.487 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr12_-_6354650 1.401 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr4_+_90252990 1.392 NM_145715
TIGD2
tigger transposable element derived 2
chr10_-_105835525 1.277 COL17A1
collagen, type XVII, alpha 1
chr12_-_51173238 1.192 NM_005554
KRT6A
keratin 6A
chr12_-_6354818 1.182 SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr10_-_105835609 1.147 NM_000494
COL17A1
collagen, type XVII, alpha 1
chr12_-_6355165 1.120 NM_001038
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr5_+_59819761 1.114 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr22_-_36836620 1.091 NM_025045
BAIAP2L2
BAI1-associated protein 2-like 2
chr2_+_161981138 1.089 TBR1
T-box, brain, 1
chr7_+_113853790 1.059 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr2_+_161981046 1.037 TBR1
T-box, brain, 1
chr2_+_161980865 1.020 NM_006593
TBR1
T-box, brain, 1
chr20_+_5935897 1.010 NM_001127458
CRLS1
cardiolipin synthase 1
chr6_+_105511615 0.994 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr22_-_36836478 0.992 BAIAP2L2
BAI1-associated protein 2-like 2
chr3_+_89239494 0.986 EPHA3
EPH receptor A3
chr8_-_110724594 0.969 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chrX_+_105823723 0.952 NM_024539
RNF128
ring finger protein 128
chr11_-_16380967 0.928 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr17_-_36347197 0.923 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr12_-_120725210 0.921 LOC338799
hypothetical LOC338799
chr12_-_28016182 0.903 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr9_-_14076901 0.902 NFIB
nuclear factor I/B
chrX_-_48212683 0.878 SLC38A5
solute carrier family 38, member 5
chr17_+_7682355 0.869


chr12_-_51200347 0.863 NM_000424
KRT5
keratin 5
chrX_-_24600661 0.838 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr17_-_36346240 0.838 KRT23
keratin 23 (histone deacetylase inducible)
chrX_-_18600108 0.817 NM_000330
RS1
retinoschisin 1
chr7_+_94135384 0.797 PEG10
paternally expressed 10
chr13_-_35327798 0.795 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr12_+_50342814 0.794 NM_001177984
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr14_+_51025604 0.787 NM_001042481
FRMD6
FERM domain containing 6
chr3_+_63928459 0.787 NM_001128149
ATXN7
ataxin 7
chr9_+_129066576 0.785 NM_032293
GARNL3
GTPase activating Rap/RanGAP domain-like 3
chr16_+_20682812 0.777 NM_005622
NM_202000
ACSM3

acyl-CoA synthetase medium-chain family member 3

chr12_+_40117751 0.771 NM_013377
PDZRN4
PDZ domain containing ring finger 4
chr5_-_59819642 0.770 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr12_-_16652202 0.769 NM_001001395
LMO3
LIM domain only 3 (rhombotin-like 2)
chr19_+_50100843 0.765 NM_000041
APOE
apolipoprotein E
chr1_-_214963279 0.750 NM_001438
ESRRG
estrogen-related receptor gamma
chr10_-_73953699 0.731 NM_001195519
CBARA1
calcium binding atopy-related autoantigen 1
chrX_+_123062143 0.727 STAG2
stromal antigen 2
chr5_-_148738980 0.709 NM_014443
IL17B
interleukin 17B
chr2_-_160764819 0.702 NM_000888
ITGB6
integrin, beta 6
chr3_-_121883647 0.691 HGD
homogentisate 1,2-dioxygenase
chr3_-_121884091 0.683 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr1_+_154297588 0.666 NM_020387
RAB25
RAB25, member RAS oncogene family
chr14_+_31868229 0.664 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr20_-_43163021 0.657 NM_002251
KCNS1
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1
chrX_+_68752635 0.656 NM_001005609
NM_001005610
NM_001005612
NM_001005613
NM_001399
EDA




ectodysplasin A




chr11_-_18214891 0.650 NM_006512
SAA4
serum amyloid A4, constitutive
chr13_+_23042722 0.642 NM_148957
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr6_+_50894397 0.634 NM_003221
TFAP2B
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
chr6_+_28237529 0.627 NM_001145129
ZNF389
zinc finger protein 389
chr4_+_74493174 0.617 ALB
albumin
chrX_-_129347101 0.610 NM_178471
GPR119
G protein-coupled receptor 119
chr7_+_139175420 0.594 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr7_-_26198673 0.585 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr4_-_23500706 0.578 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr9_+_109131814 0.577 RAD23B
RAD23 homolog B (S. cerevisiae)
chr7_+_142053693 0.563 NM_001190487
MTRNR2L6
MT-RNR2-like 6
chr12_+_54700955 0.559 NM_022465
IKZF4
IKAROS family zinc finger 4 (Eos)
chr11_+_86710076 0.558 TMEM135
transmembrane protein 135
chr10_+_7785360 0.558 ITIH2
inter-alpha (globulin) inhibitor H2
chr3_-_115960807 0.555 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr17_-_46479127 0.555 SPAG9
sperm associated antigen 9
chr5_-_39255335 0.554 NM_001465
NM_199335
FYB

FYN binding protein

chr19_-_47724365 0.553 NM_001024912
NM_001184813
NM_001184815
NM_001184816
NM_001712
CEACAM1




carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)




chr2_+_157822355 0.551 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr11_-_16454493 0.551 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chr2_-_55090759 0.550 NM_007008
RTN4
reticulon 4
chr10_+_7785347 0.548 ITIH2
inter-alpha (globulin) inhibitor H2
chr11_-_128567302 0.548 NM_001142685
ARHGAP32
Rho GTPase activating protein 32
chr20_+_56919233 0.547 GNAS
GNAS complex locus
chr8_+_9990471 0.545 NM_001135671
MSRA
methionine sulfoxide reductase A
chr13_-_85271329 0.542 NM_032229
SLITRK6
SLIT and NTRK-like family, member 6
chr15_+_38082041 0.539 EIF2AK4
eukaryotic translation initiation factor 2 alpha kinase 4
chr14_-_64479198 0.538 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr1_+_556968 0.532


chrX_+_115481774 0.526 NM_007231
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr10_-_5436781 0.526 NM_001171864
NM_024803
TUBAL3

tubulin, alpha-like 3

chr12_+_52697160 0.526 HOXC5
HOXC6
homeobox C5
homeobox C6
chr7_+_113842284 0.525 NM_001172766
NM_014491
NM_148898
NM_148900
FOXP2



forkhead box P2



chr12_-_4358968 0.524 NM_020638
FGF23
fibroblast growth factor 23
chr2_-_39310176 0.523 NM_001009565
CDKL4
cyclin-dependent kinase-like 4
chr8_-_72436519 0.522 EYA1
eyes absent homolog 1 (Drosophila)
chr19_-_53081326 0.522 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr4_+_74493301 0.522 ALB
albumin
chr8_+_67096344 0.515 NM_033105
DNAJC5B
DnaJ (Hsp40) homolog, subfamily C, member 5 beta
chr14_+_38772870 0.515 NM_054024
MIA2
melanoma inhibitory activity 2
chr9_-_14858974 0.515 FREM1
FRAS1 related extracellular matrix 1
chr10_+_24795465 0.513 KIAA1217
KIAA1217
chr19_-_53081383 0.512 NM_003167
SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr18_+_71051713 0.510 NM_005786
TSHZ1
teashirt zinc finger homeobox 1
chr11_-_83071084 0.510 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr6_-_32265489 0.507 NM_002586
PBX2
pre-B-cell leukemia homeobox 2
chr4_-_184480572 0.504 NM_001185149
CLDN24
claudin 24
chr1_+_50348052 0.504 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr5_+_127012611 0.504 NM_001048252
CTXN3
cortexin 3
chr8_+_55691179 0.498 NM_006269
RP1
retinitis pigmentosa 1 (autosomal dominant)
chr10_+_24795446 0.495 KIAA1217
KIAA1217
chr5_-_168204430 0.487


chr10_+_7785290 0.481 ITIH2
inter-alpha (globulin) inhibitor H2
chr14_+_75058518 0.480 NM_006399
BATF
basic leucine zipper transcription factor, ATF-like
chr4_+_74493266 0.479 ALB
albumin
chrX_-_130251068 0.469 NM_001170961
NM_001170962
NM_001555
NM_205833
IGSF1



immunoglobulin superfamily, member 1



chr6_-_50039776 0.465 NM_001037499
DEFB114
defensin, beta 114
chr6_+_155579788 0.464 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr7_+_128802719 0.463 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr2_-_215711313 0.461 NM_173076
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr4_-_176970895 0.460 GPM6A
glycoprotein M6A
chr14_-_20969706 0.456 NM_001170629
CHD8
chromodomain helicase DNA binding protein 8
chr1_+_221168388 0.455 NM_032890
DISP1
dispatched homolog 1 (Drosophila)
chr4_+_88939725 0.454 NM_004967
IBSP
integrin-binding sialoprotein
chr7_+_106897737 0.454 NM_005295
GPR22
G protein-coupled receptor 22
chr4_-_186970366 0.450 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr1_+_50347188 0.449 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr5_-_22889487 0.440 NM_004061
CDH12
cadherin 12, type 2 (N-cadherin 2)
chr10_+_86121526 0.438 FAM190B
family with sequence similarity 190, member B
chr10_+_7785331 0.436 ITIH2
inter-alpha (globulin) inhibitor H2
chr4_+_74493218 0.435 ALB
albumin
chr8_-_30826074 0.435 NM_031271
TEX15
testis expressed 15
chr2_-_73373956 0.431 NM_001965
EGR4
early growth response 4
chrX_-_110541029 0.430 NM_000555
DCX
doublecortin
chr10_+_102722275 0.429 NM_017893
SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr20_+_31713750 0.428 NM_080825
C20orf144
chromosome 20 open reading frame 144
chr4_+_74493331 0.428 ALB
albumin
chr6_+_31731647 0.428 NM_019101
APOM
apolipoprotein M
chr1_+_165564904 0.428 NM_001198783
POU2F1
POU class 2 homeobox 1
chr1_+_165565006 0.424 POU2F1
POU class 2 homeobox 1
chr12_+_52696908 0.423 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr3_+_190990142 0.418 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr4_+_74520796 0.417 NM_001134
AFP
alpha-fetoprotein
chr13_+_77213295 0.416 NM_144595
SLAIN1
SLAIN motif family, member 1
chr10_-_98021144 0.415 NM_001114094
NM_013314
BLNK

B-cell linker

chr11_+_20001130 0.413 NM_001111019
NAV2
neuron navigator 2
chr14_-_37134050 0.411 FOXA1
forkhead box A1
chr6_+_31731667 0.408 APOM
apolipoprotein M
chr9_-_205892 0.407 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr12_+_14429499 0.402 ATF7IP
activating transcription factor 7 interacting protein
chr20_+_30160952 0.400 NM_014742
TM9SF4
transmembrane 9 superfamily protein member 4
chr18_+_27152049 0.397 NM_001942
DSG1
desmoglein 1
chr2_-_200033445 0.396 SATB2
SATB homeobox 2
chr2_+_17861266 0.391 NM_001105569
MSGN1
mesogenin 1
chr2_+_174907914 0.388 NM_001145250
SP9
Sp9 transcription factor homolog (mouse)
chr5_+_140583098 0.388 NM_018934
PCDHB14
protocadherin beta 14
chr3_+_39484073 0.387 NM_182935
MOBP
myelin-associated oligodendrocyte basic protein
chr15_+_56511466 0.386 NM_000236
LIPC
lipase, hepatic
chr12_-_6615348 0.385 NM_020400
LPAR5
lysophosphatidic acid receptor 5
chr13_-_59485299 0.381 NM_030932
DIAPH3
diaphanous homolog 3 (Drosophila)
chr13_+_97856148 0.381


chr4_+_69716298 0.380 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr12_-_121767272 0.378 NM_006018
GPR109B
G protein-coupled receptor 109B
chr7_-_25234582 0.376 NM_022150
NPVF
neuropeptide VF precursor
chr4_+_71418886 0.374 NM_212557
AMTN
amelotin
chr7_-_96471544 0.373 DLX6-AS1
DLX6 antisense RNA 1 (non-protein coding)
chr8_-_72437020 0.372 NM_000503
EYA1
eyes absent homolog 1 (Drosophila)
chr3_+_161425946 0.371 NM_001168214
LOC401097
hypothetical protein LOC401097
chr14_-_46882144 0.371 NM_182830
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr4_-_100070808 0.370 NM_001130679
NM_001968
EIF4E

eukaryotic translation initiation factor 4E

chr1_+_154520693 0.367 NM_032323
TMEM79
transmembrane protein 79
chr19_-_5789740 0.366 FUT6
fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
chr3_+_46370578 0.365 CCR2
chemokine (C-C motif) receptor 2
chrX_-_135783496 0.365


chr22_-_16127520 0.364 CECR3
cat eye syndrome chromosome region, candidate 3
chr16_-_4792857 0.363 ROGDI
rogdi homolog (Drosophila)
chr2_+_143603439 0.363 ARHGAP15
Rho GTPase activating protein 15
chr7_+_129634935 0.363 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr6_+_16251260 0.358 MYLIP
myosin regulatory light chain interacting protein
chr12_-_116890410 0.357 NM_173598
KSR2
kinase suppressor of ras 2
chr14_-_37134191 0.357 NM_004496
FOXA1
forkhead box A1
chr14_+_75058591 0.356 BATF
basic leucine zipper transcription factor, ATF-like
chr6_-_136888771 0.355 NM_001198608
NM_001198609
NM_001198611
MAP7


microtubule-associated protein 7


chr17_+_71232370 0.354 NM_001005619
ITGB4
integrin, beta 4
chr20_+_12937616 0.354 NM_018327
SPTLC3
serine palmitoyltransferase, long chain base subunit 3
chr1_-_114215768 0.354 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr13_-_46368968 0.354 NM_000621
NM_001165947
HTR2A

5-hydroxytryptamine (serotonin) receptor 2A

chr15_+_97990705 0.351 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr14_+_69307914 0.351 SRSF5
serine/arginine-rich splicing factor 5
chr10_-_52315390 0.349 A1CF
APOBEC1 complementation factor
chr8_-_40874485 0.345 NM_001135731
NM_024645
ZMAT4

zinc finger, matrin-type 4

chr3_+_89239363 0.345 NM_005233
NM_182644
EPHA3

EPH receptor A3

chr7_+_116238309 0.345 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr21_-_32879617 0.341 NM_144659
TCP10L
t-complex 10 (mouse)-like
chr17_+_24394281 0.340 PIPOX
pipecolic acid oxidase
chr16_-_45339605 0.339 NM_182493
MYLK3
myosin light chain kinase 3
chr8_-_17624009 0.339 NM_001001931
MTUS1
microtubule associated tumor suppressor 1
chr6_-_53121540 0.339 NM_003643
GCM1
glial cells missing homolog 1 (Drosophila)
chr20_-_33706532 0.338 RBM12
RNA binding motif protein 12
chr12_-_56422120 0.336 NM_014770
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr1_+_50347176 0.335 NM_001144774
NM_021952
ELAVL4

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.36 4.80e-10 GO:0032501 multicellular organismal process
2.29 1.26e-06 GO:0007606 sensory perception of chemical stimulus
1.93 1.90e-06 GO:0007600 sensory perception
1.60 3.10e-06 GO:0003008 system process
2.32 5.61e-06 GO:0007608 sensory perception of smell
1.25 1.04e-05 GO:0050896 response to stimulus
1.65 1.53e-05 GO:0050877 neurological system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.28 8.48e-05 GO:0071944 cell periphery
1.28 8.99e-05 GO:0005886 plasma membrane
1.20 5.76e-03 GO:0016021 integral to membrane
1.19 6.62e-03 GO:0031224 intrinsic to membrane
1.70 1.09e-02 GO:0030054 cell junction
1.16 1.21e-02 GO:0044425 membrane part
1.34 1.54e-02 GO:0005576 extracellular region
1.32 2.23e-02 GO:0044459 plasma membrane part
2.24 4.23e-02 GO:0030424 axon

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.63 6.42e-08 GO:0004872 receptor activity
1.54 2.56e-07 GO:0004871 signal transducer activity
1.54 2.56e-07 GO:0060089 molecular transducer activity
1.71 5.78e-07 GO:0004888 transmembrane receptor activity
2.30 4.43e-06 GO:0004984 olfactory receptor activity
1.80 2.41e-05 GO:0004930 G-protein coupled receptor activity