Motif ID: ESRRA.p2

Z-value: 2.465


Transcription factors associated with ESRRA.p2:

Gene SymbolEntrez IDGene Name
ESRRA 2101 estrogen-related receptor alpha



Activity profile for motif ESRRA.p2.

activity profile for motif ESRRA.p2


Sorted Z-values histogram for motif ESRRA.p2

Sorted Z-values for motif ESRRA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ESRRA.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_143706265 5.615 PDE4DIP
phosphodiesterase 4D interacting protein
chr1_-_143706196 4.363 PDE4DIP
phosphodiesterase 4D interacting protein
chr19_+_540849 4.347 NM_001194
HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr20_+_36867708 3.782 NM_001172735
NM_015568
PPP1R16B

protein phosphatase 1, regulatory (inhibitor) subunit 16B

chr19_-_44518465 3.549 GMFG
glia maturation factor, gamma
chr19_-_4486202 3.525 NM_001013706
PLIN5
perilipin 5
chr19_+_17923110 3.510 NM_002248
KCNN1
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
chr19_-_44518516 2.868 NM_004877
GMFG
glia maturation factor, gamma
chr11_-_64268841 2.860 NM_001098670
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr4_-_40212670 2.466 NM_019027
RBM47
RNA binding motif protein 47
chr11_-_64268126 2.464 NM_001098671
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr22_+_18485145 2.206 RANBP1
RAN binding protein 1
chr12_-_52980984 2.023 NM_001136023
NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr12_-_52980914 2.020 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr5_-_1647617 1.951 SDHAP3
succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 3
chrX_+_65152004 1.856


chr12_-_116021473 1.824 NM_001168325
NM_017899
TESC

tescalcin

chr22_+_18485095 1.821 RANBP1
RAN binding protein 1
chr14_+_87560646 1.819 LOC283587
hypothetical protein LOC283587
chr22_+_18485076 1.797 RANBP1
RAN binding protein 1
chr7_+_128795280 1.764 AHCYL2
adenosylhomocysteinase-like 2
chr1_-_199259447 1.746 NM_017596
KIF21B
kinesin family member 21B
chr2_+_119905812 1.718 NM_183240
TMEM37
transmembrane protein 37
chr17_-_77386156 1.712 DYSFIP1
dysferlin interacting protein 1
chr22_+_18485068 1.695 RANBP1
RAN binding protein 1
chr6_+_37081387 1.690 NM_173558
FGD2
FYVE, RhoGEF and PH domain containing 2
chr1_+_32489426 1.689 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr17_-_77386212 1.685 NM_001007533
DYSFIP1
dysferlin interacting protein 1
chr20_+_41621079 1.667 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr6_+_44076281 1.660 NM_001171992
NM_153246
C6orf223

chromosome 6 open reading frame 223

chr22_+_35586950 1.649 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr7_+_128795178 1.629 NM_001130723
AHCYL2
adenosylhomocysteinase-like 2
chr9_-_130006309 1.579 NM_001131015
NM_012127
CIZ1

CDKN1A interacting zinc finger protein 1

chr9_+_130005489 1.550 DNM1
dynamin 1
chr4_-_38460983 1.548 NM_001017388
NM_001195106
NM_001195107
NM_001195108
NM_030956
TLR10




toll-like receptor 10




chr20_+_41621119 1.540 SGK2
serum/glucocorticoid regulated kinase 2
chr3_-_122862391 1.514 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr10_+_80777265 1.507 PPIF
peptidylprolyl isomerase F
chr11_-_780103 1.499 NM_016564
CEND1
cell cycle exit and neuronal differentiation 1
chr9_+_130005429 1.490 NM_001005336
NM_004408
DNM1

dynamin 1

chr9_+_130005487 1.481 DNM1
dynamin 1
chr12_-_107257205 1.466 NM_001142343
NM_001142344
NM_004072
CMKLR1


chemokine-like receptor 1


chr15_-_76210611 1.419 NM_006383
CIB2
calcium and integrin binding family member 2
chr7_-_38355949 1.410


chr11_-_780065 1.402 CEND1
cell cycle exit and neuronal differentiation 1
chr10_+_80777248 1.401 PPIF
peptidylprolyl isomerase F
chr5_+_176807931 1.395 NM_001174102
PRR7
proline rich 7 (synaptic)
chr19_-_3013880 1.393 NM_198969
AES
amino-terminal enhancer of split
chr3_-_50580066 1.389 NM_001171740
NM_001171743
NM_016210
C3orf18


chromosome 3 open reading frame 18


chr6_+_34314545 1.386 NM_145905
HMGA1
high mobility group AT-hook 1
chr1_-_143706300 1.379 NM_001002812
NM_014644
NM_001002810
NM_001198834
NM_001195261
PDE4DIP




phosphodiesterase 4D interacting protein




chr7_-_38356100 1.366 TRGV5
T cell receptor gamma variable 5
chr5_+_175902117 1.359 NM_001171976
CDHR2
cadherin-related family member 2
chr22_-_22440054 1.347 NM_213720
CHCHD10
coiled-coil-helix-coiled-coil-helix domain containing 10
chr14_-_95250155 1.346 NM_001098725
NM_021966
TCL1A

T-cell leukemia/lymphoma 1A

chr17_-_70430839 1.333 NM_173477
USH1G
Usher syndrome 1G (autosomal recessive)
chr19_+_62434188 1.327 NM_001015879
NM_003160
NM_001015878
AURKC


aurora kinase C


chr12_-_3732478 1.288 EFCAB4B
EF-hand calcium binding domain 4B
chr22_+_18484810 1.284 NM_002882
RANBP1
RAN binding protein 1
chr22_+_18485057 1.264 RANBP1
RAN binding protein 1
chr20_-_61600834 1.259 NM_001958
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr1_+_181028016 1.250 NM_030769
NPL
N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
chr8_-_61356436 1.245 NM_004056
CA8
carbonic anhydrase VIII
chr11_-_64459910 1.235 NM_130769
GPHA2
glycoprotein hormone alpha 2
chr19_-_3013768 1.224 AES
amino-terminal enhancer of split
chr3_-_122862447 1.217 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr6_-_146098589 1.186 NM_001018041
NM_005670
EPM2A

epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)

chr1_-_203985932 1.185


chr19_-_3013441 1.182 AES
amino-terminal enhancer of split
chr19_-_3013191 1.170 NM_001130
NM_198970
AES

amino-terminal enhancer of split

chr7_+_150413814 1.157 AGAP3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
chr19_-_43800374 1.153 NM_001042600
NM_007181
MAP4K1

mitogen-activated protein kinase kinase kinase kinase 1

chr19_-_60360768 1.129 NM_000363
TNNI3
troponin I type 3 (cardiac)
chr6_+_44418374 1.116 NM_145026
SPATS1
spermatogenesis associated, serine-rich 1
chr7_-_86942910 1.107 NM_000443
NM_018849
NM_018850
ABCB4


ATP-binding cassette, sub-family B (MDR/TAP), member 4


chr19_-_51168396 1.105 NM_002516
NOVA2
neuro-oncological ventral antigen 2
chr19_+_1358531 1.105 NM_018959
NM_170711
DAZAP1

DAZ associated protein 1

chr16_+_631902 1.101 FAM195A
family with sequence similarity 195, member A
chr7_-_150408824 1.086 NM_006712
NM_033015
FASTK

Fas-activated serine/threonine kinase

chr11_-_64284762 1.086 NM_001164716
NM_005609
PYGM

phosphorylase, glycogen, muscle

chr22_-_48866484 1.082 NM_015166
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr22_+_29151651 1.075 NM_001003704
NM_016498
MTFP1

mitochondrial fission process 1

chr1_-_203985963 1.045 NM_022731
NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr1_-_200396354 1.037 NM_002832
PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr1_-_201194322 1.022 NM_001127687
ADIPOR1
adiponectin receptor 1
chr1_+_46413335 1.021 NM_005727
TSPAN1
tetraspanin 1
chr1_-_202726068 1.017 NM_002646
PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr5_-_142795269 0.996 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr3_-_49701085 0.991 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr7_-_150408785 0.990 FASTK
Fas-activated serine/threonine kinase
chr17_+_77289804 0.986 SLC25A10
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
chrX_+_135407336 0.982 NM_014500
HTATSF1
HIV-1 Tat specific factor 1
chr1_+_148603769 0.978 RPRD2
regulation of nuclear pre-mRNA domain containing 2
chr11_-_56951132 0.965 SLC43A3
solute carrier family 43, member 3
chr12_+_50104859 0.961 NM_001039960
NM_004858
SLC4A8

solute carrier family 4, sodium bicarbonate cotransporter, member 8

chr6_-_108252200 0.958 NM_198081
SCML4
sex comb on midleg-like 4 (Drosophila)
chr6_-_34468076 0.954 NUDT3
nudix (nucleoside diphosphate linked moiety X)-type motif 3
chr17_+_77289775 0.952 NM_012140
SLC25A10
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
chr1_-_1679940 0.949 NM_001198995
NADK
NAD kinase
chrX_+_153310313 0.948 ATP6AP1
ATPase, H+ transporting, lysosomal accessory protein 1
chr11_-_56951167 0.923 NM_199329
SLC43A3
solute carrier family 43, member 3
chr19_+_59796858 0.908 NM_006863
LILRA1
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
chr14_-_105245959 0.904 IGHA1
immunoglobulin heavy constant alpha 1
chr1_+_42619014 0.903 NM_173642
RIMKLA
ribosomal modification protein rimK-like family member A
chr6_-_43135092 0.895 NM_015950
MRPL2
mitochondrial ribosomal protein L2
chr6_+_31662454 0.895 NM_205837
LST1
leukocyte specific transcript 1
chr2_+_219453487 0.891 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr6_-_135312899 0.884 NM_001193480
NM_022568
NM_170771
ALDH8A1


aldehyde dehydrogenase 8 family, member A1


chr19_+_50693570 0.877 NM_001080401
PPM1N
protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative)
chrX_-_44087778 0.876 NM_025184
EFHC2
EF-hand domain (C-terminal) containing 2
chr9_-_129719031 0.857 NM_175039
NM_175040
ST6GALNAC4

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4

chr16_+_631828 0.856 NM_138418
FAM195A
family with sequence similarity 195, member A
chr11_-_56951088 0.856 NM_014096
SLC43A3
solute carrier family 43, member 3
chr19_-_45947667 0.856 NM_198476
C19orf54
chromosome 19 open reading frame 54
chr19_+_7734034 0.849 NM_001144904
NM_001144905
NM_001144906
NM_001144907
NM_001144908
NM_001144909
NM_001144910
NM_001144911
NM_014257
CLEC4M








C-type lectin domain family 4, member M








chr1_+_29011240 0.848 NM_000911
OPRD1
opioid receptor, delta 1
chr1_+_38032045 0.848 NM_001031740
NM_001113482
MANEAL

mannosidase, endo-alpha-like

chr2_-_172675873 0.843 DLX2
distal-less homeobox 2
chr19_-_13074973 0.841 NM_005583
LYL1
lymphoblastic leukemia derived sequence 1
chr19_-_1463997 0.836 ADAMTSL5
ADAMTS-like 5
chr11_-_60379998 0.823 NM_004778
GPR44
G protein-coupled receptor 44
chr10_-_97190885 0.821 NM_001034954
NM_001034955
NM_001034956
NM_001034957
NM_006434
SORBS1




sorbin and SH3 domain containing 1




chr1_-_45224784 0.814 EIF2B3
eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
chr10_-_91394881 0.805 PANK1
pantothenate kinase 1
chr16_+_31274020 0.798 ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chrX_+_46938136 0.794 NM_003334
UBA1
ubiquitin-like modifier activating enzyme 1
chr17_-_34015631 0.793 NM_025248
SRCIN1
SRC kinase signaling inhibitor 1
chr1_-_172153087 0.783 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr1_-_152431175 0.781 NM_152263
TPM3
tropomyosin 3
chr11_+_73176561 0.764 NM_016055
MRPL48
mitochondrial ribosomal protein L48
chr7_+_73136254 0.760 LIMK1
LIM domain kinase 1
chr10_+_80777234 0.750 PPIF
peptidylprolyl isomerase F
chr1_+_234916376 0.749 NM_001103
ACTN2
actinin, alpha 2
chr1_+_119851348 0.748 NM_000862
HSD3B1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
chrX_-_47374187 0.745 NM_001145252
CFP
complement factor properdin
chr13_-_113151453 0.744 NM_199162
ADPRHL1
ADP-ribosylhydrolase like 1
chr1_-_200396328 0.744 PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr17_-_39500512 0.743 NM_152344
LSM12
LSM12 homolog (S. cerevisiae)
chr8_+_100025806 0.742 NM_001142462
NM_053001
OSR2

odd-skipped related 2 (Drosophila)

chrX_+_65299157 0.738 NM_138737
HEPH
hephaestin
chrX_+_46938157 0.735 UBA1
ubiquitin-like modifier activating enzyme 1
chr5_+_143171918 0.727 NM_021182
HMHB1
histocompatibility (minor) HB-1
chr8_-_131097856 0.727 FAM49B
family with sequence similarity 49, member B
chr17_+_27493654 0.721 RHOT1
ras homolog gene family, member T1
chr17_+_27493486 0.713 NM_001033566
NM_001033568
NM_018307
RHOT1


ras homolog gene family, member T1


chrX_-_149817785 0.709 NM_001184808
NM_031462
NM_134445
NM_134446
CD99L2



CD99 molecule-like 2



chr3_+_46423682 0.708 NM_003965
NM_001130910
CCRL2

chemokine (C-C motif) receptor-like 2

chr9_-_99994704 0.708 NM_052820
CORO2A
coronin, actin binding protein, 2A
chr17_+_27493618 0.705 RHOT1
ras homolog gene family, member T1
chr22_-_48865980 0.694 MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr10_+_80777199 0.693 NM_005729
PPIF
peptidylprolyl isomerase F
chr5_+_137253023 0.692 NM_014386
PKD2L2
polycystic kidney disease 2-like 2
chr7_-_100630912 0.687 NM_178176
MOGAT3
monoacylglycerol O-acyltransferase 3
chr7_+_97679501 0.683 NM_177455
BHLHA15
basic helix-loop-helix family, member a15
chr1_-_155053124 0.681 NM_001161441
NM_001161442
NM_001161444
NM_003975
SH2D2A



SH2 domain containing 2A



chr8_-_131097828 0.679 FAM49B
family with sequence similarity 49, member B
chr16_+_21623784 0.678 NM_170664
OTOA
otoancorin
chr6_-_97452416 0.675 NDUFAF4
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4
chr1_+_159438798 0.672 NDUFS2
NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
chr6_-_37062193 0.672 MTCH1
mitochondrial carrier homolog 1 (C. elegans)
chr16_+_31274030 0.671 ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr9_+_131291224 0.670 LOC100506190
hypothetical LOC100506190
chrX_+_46938178 0.667 UBA1
ubiquitin-like modifier activating enzyme 1
chr19_-_1464187 0.664 NM_213604
ADAMTSL5
ADAMTS-like 5
chr1_+_40769877 0.661 ZNF684
zinc finger protein 684
chr4_+_74520796 0.660 NM_001134
AFP
alpha-fetoprotein
chrX_-_149817720 0.660 CD99L2
CD99 molecule-like 2
chr1_+_159438810 0.659 NDUFS2
NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
chr19_-_62759536 0.659 NM_001039654
ZNF550
zinc finger protein 550
chrX_+_46938171 0.657 UBA1
ubiquitin-like modifier activating enzyme 1
chr5_-_35266305 0.655 PRLR
prolactin receptor
chr17_+_40580466 0.653 NM_006460
HEXIM1
hexamethylene bis-acetamide inducible 1
chr5_+_138920893 0.652 NM_003339
NM_181838
UBE2D2

ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)

chr1_+_40769819 0.651 NM_152373
ZNF684
zinc finger protein 684
chr7_-_102576570 0.650 NM_001122838
NM_198990
NAPEPLD

N-acyl phosphatidylethanolamine phospholipase D

chr1_+_159438787 0.646 NDUFS2
NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
chr19_+_1358604 0.645 DAZAP1
DAZ associated protein 1
chr1_+_159438749 0.645 NDUFS2
NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
chr5_-_150517528 0.645 NM_001155
ANXA6
annexin A6
chr17_+_27493680 0.641 RHOT1
ras homolog gene family, member T1
chr8_-_145521108 0.639 DGAT1
diacylglycerol O-acyltransferase 1
chr19_-_44014228 0.638 NM_001398
ECH1
enoyl CoA hydratase 1, peroxisomal
chr19_-_14771947 0.636 NM_198944
OR7C1
olfactory receptor, family 7, subfamily C, member 1
chr19_+_50863341 0.634 NM_000164
GIPR
gastric inhibitory polypeptide receptor
chr1_+_205293217 0.629 NM_001018053
NM_006212
PFKFB2

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

chr10_-_81955256 0.626 ANXA11
annexin A11
chr1_-_27582368 0.623 NM_207397
CD164L2
CD164 sialomucin-like 2
chr22_+_22703107 0.617 NM_001144931
LOC391322
D-dopachrome tautomerase-like
chr10_+_22645370 0.615 COMMD3
COMM domain containing 3
chr20_-_44713466 0.612 NM_001193339
NM_001193342
NM_022829
SLC13A3


solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3


chr1_+_234625338 0.610 NM_080738
EDARADD
EDAR-associated death domain
chrX_-_47374647 0.605 NM_002621
CFP
complement factor properdin
chr17_-_40339919 0.602 GFAP
glial fibrillary acidic protein
chr1_+_157441133 0.602 NM_002036
DARC
Duffy blood group, chemokine receptor
chr1_-_172153024 0.601 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr19_+_44886785 0.593 NM_020129
NM_203471
LGALS14

lectin, galactoside-binding, soluble, 14

chr6_+_31662954 0.592 NM_001166538
NM_007161
NM_205840
LST1


leukocyte specific transcript 1


chrX_+_153908426 0.591 FUNDC2
FUN14 domain containing 2
chr2_-_27339278 0.589 NM_003459
SLC30A3
solute carrier family 30 (zinc transporter), member 3
chrX_+_153908257 0.589 NM_023934
FUNDC2
FUN14 domain containing 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.44 4.71e-06 GO:0006810 transport
1.42 1.80e-05 GO:0051234 establishment of localization
1.33 9.29e-04 GO:0051179 localization
1.65 1.54e-02 GO:0055114 oxidation-reduction process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.79 1.01e-08 GO:0005739 mitochondrion
2.33 1.93e-07 GO:0005740 mitochondrial envelope
2.35 2.54e-07 GO:0031966 mitochondrial membrane
2.65 3.01e-07 GO:0005743 mitochondrial inner membrane
2.05 4.76e-07 GO:0044429 mitochondrial part
2.54 5.88e-07 GO:0019866 organelle inner membrane
1.90 1.28e-05 GO:0031975 envelope
1.88 2.80e-05 GO:0031967 organelle envelope
1.21 5.34e-04 GO:0044444 cytoplasmic part
1.15 1.79e-03 GO:0005737 cytoplasm
2.82 8.70e-03 GO:0044455 mitochondrial membrane part
4.99 1.69e-02 GO:0000932 cytoplasmic mRNA processing body

Nothing significant found in function category.