Motif ID: EP300.p2

Z-value: 3.864


Transcription factors associated with EP300.p2:

Gene SymbolEntrez IDGene Name
EP300 2033 E1A binding protein p300



Activity profile for motif EP300.p2.

activity profile for motif EP300.p2


Sorted Z-values histogram for motif EP300.p2

Sorted Z-values for motif EP300.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EP300.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_156229934 5.106 KIRREL
kin of IRRE like (Drosophila)
chr10_-_126839546 4.692 NM_001083914
CTBP2
C-terminal binding protein 2
chr5_+_96024434 4.552 CAST
calpastatin
chr5_+_174084137 4.357 NM_002449
MSX2
msh homeobox 2
chr12_+_6179736 3.679 NM_001769
CD9
CD9 molecule
chr8_-_122722674 3.655 NM_005328
HAS2
hyaluronan synthase 2
chr4_+_183302105 3.435 ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr8_-_145085616 3.345 NM_201384
PLEC
plectin
chr13_-_43259032 3.212 NM_017993
ENOX1
ecto-NOX disulfide-thiol exchanger 1
chr2_+_109729176 3.188 NM_023016
ANKRD57
ankyrin repeat domain 57
chr3_+_160964574 3.159 SCHIP1
schwannomin interacting protein 1
chr12_-_26169074 3.122 NM_030762
BHLHE41
basic helix-loop-helix family, member e41
chr3_-_38046034 3.101 NM_006225
PLCD1
phospholipase C, delta 1
chr10_-_49483002 3.050 NM_021226
ARHGAP22
Rho GTPase activating protein 22
chr11_+_131286513 3.037 NTM
neurotrimin
chr9_+_35782405 2.961 NM_003995
NPR2
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
chr15_-_66511488 2.952 NM_001004439
ITGA11
integrin, alpha 11
chr3_+_156280539 2.940 MME
membrane metallo-endopeptidase
chr4_-_122213018 2.884 NM_024574
C4orf31
chromosome 4 open reading frame 31
chr9_-_116920232 2.734 NM_002160
TNC
tenascin C
chr3_+_156280497 2.734 MME
membrane metallo-endopeptidase
chr1_-_151852128 2.685 NM_080388
S100A16
S100 calcium binding protein A16
chr1_+_179148935 2.677 NM_020950
KIAA1614
KIAA1614
chr17_-_24068759 2.660 NM_001144942
NM_031934
RAB34

RAB34, member RAS oncogene family

chr4_-_177950658 2.639 NM_005429
VEGFC
vascular endothelial growth factor C
chr15_+_66658626 2.614 NM_006091
CORO2B
coronin, actin binding protein, 2B
chr1_+_156229686 2.609 NM_018240
KIRREL
kin of IRRE like (Drosophila)
chr9_+_111442888 2.604 NM_001037293
PALM2
paralemmin 2
chrX_-_140098941 2.578 LDOC1
leucine zipper, down-regulated in cancer 1
chr6_-_72187168 2.569 C6orf155
chromosome 6 open reading frame 155
chr12_-_47468985 2.555 NM_020983
ADCY6
adenylate cyclase 6
chr9_+_108665168 2.537 NM_021224
ZNF462
zinc finger protein 462
chr1_+_213323182 2.497 NM_001017425
NM_014217
KCNK2

potassium channel, subfamily K, member 2

chr2_+_130846263 2.458 PTPN18
protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
chr2_-_109728958 2.435 NM_144710
NM_178584
SEPT10

septin 10

chr3_+_113061330 2.406 PHLDB2
pleckstrin homology-like domain, family B, member 2
chr8_+_106400322 2.391 NM_012082
ZFPM2
zinc finger protein, multitype 2
chr15_-_81743198 2.377 BNC1
basonuclin 1
chr3_+_113061296 2.365 PHLDB2
pleckstrin homology-like domain, family B, member 2
chr17_-_76985538 2.315


chr7_-_45927263 2.311 NM_000598
NM_001013398
IGFBP3

insulin-like growth factor binding protein 3

chr1_-_159275357 2.279 NM_001113205
NM_001113206
NM_001113207
TSTD1


F11R
thiosulfate sulfurtransferase (rhodanese)-like domain containing 1


F11 receptor
chrX_-_140098871 2.277 LDOC1
leucine zipper, down-regulated in cancer 1
chrX_-_140098959 2.265 NM_012317
LDOC1
leucine zipper, down-regulated in cancer 1
chr3_+_113061218 2.236 NM_001134439
PHLDB2
pleckstrin homology-like domain, family B, member 2
chr2_-_40532651 2.185 SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chrX_-_140099014 2.178 LDOC1
leucine zipper, down-regulated in cancer 1
chr1_-_16355013 2.151 NM_004431
EPHA2
EPH receptor A2
chr15_+_90738108 2.135 NM_006011
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr2_-_189752575 2.108 NM_000393
COL5A2
collagen, type V, alpha 2
chr2_-_56266408 2.078 LOC100129434
hypothetical LOC100129434
chr16_+_85158357 2.060 NM_005251
FOXC2
forkhead box C2 (MFH-1, mesenchyme forkhead 1)
chr1_-_94779727 2.056 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr3_-_79151232 2.053 NM_001145845
NM_133631
ROBO1

roundabout, axon guidance receptor, homolog 1 (Drosophila)

chr4_-_142273881 2.047 NM_020724
RNF150
ring finger protein 150
chr9_-_25668230 2.027 TUSC1
tumor suppressor candidate 1
chr13_-_32822759 2.020 STARD13
StAR-related lipid transfer (START) domain containing 13
chrX_+_37093448 2.008 NM_000950
NM_001142395
NM_001173486
NM_001173489
NM_001173490
PRRG1




proline rich Gla (G-carboxyglutamic acid) 1




chr11_+_35117226 1.990 CD44
CD44 molecule (Indian blood group)
chr10_+_102782156 1.987 SFXN3
sideroflexin 3
chr7_-_117300763 1.958 NM_033427
CTTNBP2
cortactin binding protein 2
chr10_+_52504239 1.945 NM_006258
PRKG1
protein kinase, cGMP-dependent, type I
chr13_-_37341859 1.933 NM_001135955
NM_001135956
NM_001135957
NM_001135958
NM_003306
NM_016179
TRPC4





transient receptor potential cation channel, subfamily C, member 4





chr1_+_199519202 1.932 NM_000299
NM_001005337
PKP1

plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)

chr14_+_78815406 1.927 NM_001105250
NM_138970
NRXN3

neurexin 3

chr2_-_160627366 1.901 NM_001007267
NM_001195641
NM_007366
PLA2R1


phospholipase A2 receptor 1, 180kDa


chr11_-_122571198 1.896 NM_024769
CLMP
CXADR-like membrane protein
chr2_+_109112428 1.891 NM_001099289
SH3RF3
SH3 domain containing ring finger 3
chr7_-_32076985 1.876 NM_001191056
NM_001191057
PDE1C

phosphodiesterase 1C, calmodulin-dependent 70kDa

chr13_+_113546841 1.860 NM_000820
GAS6
growth arrest-specific 6
chr3_+_156280604 1.857 NM_007288
MME
membrane metallo-endopeptidase
chr17_+_4922445 1.851 NM_153018
ZFP3
zinc finger protein 3 homolog (mouse)
chr4_-_187884721 1.849


chr2_+_149895274 1.849 NM_194317
LYPD6
LY6/PLAUR domain containing 6
chr11_-_72111027 1.836 NM_001135190
NM_015242
ARAP1

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

chr1_-_68470585 1.835 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr4_-_122063118 1.832 NM_018699
PRDM5
PR domain containing 5
chr10_+_20145350 1.825 NM_032812
PLXDC2
plexin domain containing 2
chr9_+_119506428 1.817 TLR4
toll-like receptor 4
chr4_-_5761194 1.817 NM_147127
EVC2
Ellis van Creveld syndrome 2
chr19_-_60573552 1.812 NM_000641
IL11
interleukin 11
chr3_+_156280129 1.801 NM_000902
MME
membrane metallo-endopeptidase
chr9_+_115396020 1.793 NM_144489
RGS3
regulator of G-protein signaling 3
chr2_-_229844198 1.792 NM_001100818
NM_017933
PID1

phosphotyrosine interaction domain containing 1

chr2_-_160627181 1.790 PLA2R1
phospholipase A2 receptor 1, 180kDa
chr17_+_4922478 1.784 ZFP3
zinc finger protein 3 homolog (mouse)
chr17_+_52026058 1.763 NM_005450
NOG
noggin
chr15_-_80123935 1.734 MEX3B
mex-3 homolog B (C. elegans)
chr16_+_639278 1.695 NM_145294
WDR90
WD repeat domain 90
chr4_-_122905731 1.686 NM_152399
TMEM155
transmembrane protein 155
chr14_+_92049396 1.677 NM_024832
RIN3
Ras and Rab interactor 3
chr11_-_27677755 1.672 NM_170734
BDNF
brain-derived neurotrophic factor
chr11_+_12355600 1.667 NM_018222
PARVA
parvin, alpha
chr11_+_129823667 1.632 NM_139055
ADAMTS15
ADAM metallopeptidase with thrombospondin type 1 motif, 15
chr12_-_57600564 1.627 LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr6_-_33822659 1.620 NM_001142883
NM_054111
IP6K3

inositol hexakisphosphate kinase 3

chr12_+_52653176 1.619 NM_014212
HOXC11
homeobox C11
chr18_-_20231783 1.607 NM_080597
OSBPL1A
oxysterol binding protein-like 1A
chr7_-_32077504 1.601 NM_001191059
NM_005020
PDE1C

phosphodiesterase 1C, calmodulin-dependent 70kDa

chr11_+_696607 1.597 EPS8L2
EPS8-like 2
chr10_+_46413551 1.593 NM_014696
GPRIN2
G protein regulated inducer of neurite outgrowth 2
chr9_+_126671321 1.592 ARPC5L
actin related protein 2/3 complex, subunit 5-like
chr2_+_182030173 1.589 ITGA4
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
chr10_+_52421120 1.583 PRKG1
protein kinase, cGMP-dependent, type I
chr18_-_20231709 1.578 OSBPL1A
oxysterol binding protein-like 1A
chr4_+_167013859 1.575 NM_012464
TLL1
tolloid-like 1
chr1_+_203064397 1.573 NM_001005388
NM_001005389
NM_001160332
NM_001160333
NM_015090
NFASC




neurofascin




chr13_-_39075304 1.567 LHFP
lipoma HMGIC fusion partner
chrX_-_1470862 1.562 NM_001636
SLC25A6
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
chr19_+_46417117 1.556 AXL
AXL receptor tyrosine kinase
chr5_+_178300799 1.549 NM_001178089
NM_001178090
NM_182594
ZNF454


zinc finger protein 454


chr12_+_52806103 1.548 LOC400043
hypothetical LOC400043
chr11_+_104986620 1.535 NM_001112812
GRIA4
glutamate receptor, ionotrophic, AMPA 4
chr9_-_20612433 1.528 MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr19_+_10900502 1.527 C19orf52
chromosome 19 open reading frame 52
chr2_+_191818124 1.523 NM_001130158
NM_012223
NM_001161819
MYO1B


myosin IB


chr11_+_124539814 1.519 PKNOX2
PBX/knotted 1 homeobox 2
chr17_-_72045218 1.517 NM_134268
CYGB
cytoglobin
chr10_-_116154504 1.512 NM_001001936
NM_032550
AFAP1L2

actin filament associated protein 1-like 2

chr9_+_71848555 1.510 MAMDC2
MAM domain containing 2
chr10_+_52420936 1.505 NM_001098512
PRKG1
protein kinase, cGMP-dependent, type I
chr11_+_92342436 1.505 NM_005959
MTNR1B
melatonin receptor 1B
chr13_+_113546897 1.486 GAS6
growth arrest-specific 6
chrX_-_99551926 1.483 NM_001105243
NM_001184880
NM_020766
PCDH19


protocadherin 19


chr11_+_35116961 1.483 NM_000610
NM_001001389
NM_001001390
NM_001001391
NM_001001392
CD44




CD44 molecule (Indian blood group)




chr5_+_31229549 1.482 NM_004932
CDH6
cadherin 6, type 2, K-cadherin (fetal kidney)
chr10_-_30388439 1.472 NM_020848
KIAA1462
KIAA1462
chr19_-_61680510 1.472 NM_022103
ZNF667
zinc finger protein 667
chr3_+_156280338 1.470 NM_007287
MME
membrane metallo-endopeptidase
chr22_+_40800213 1.466 FAM109B
family with sequence similarity 109, member B
chr13_+_113546912 1.464 GAS6
growth arrest-specific 6
chr17_+_76988134 1.457 NM_001080519
BAHCC1
BAH domain and coiled-coil containing 1
chr1_+_202308814 1.457 NM_005686
SOX13
SRY (sex determining region Y)-box 13
chr2_-_109728693 1.449 SEPT10
septin 10
chr9_+_119506446 1.429 TLR4
toll-like receptor 4
chr4_-_186693574 1.428 NM_001114107
NM_014476
PDLIM3

PDZ and LIM domain 3

chr5_-_92982927 1.428


chr16_-_85099941 1.425 LOC400550
hypothetical LOC400550
chr7_+_128257698 1.425 NM_001127487
NM_001458
FLNC

filamin C, gamma

chr18_-_33399997 1.424 NM_001025087
NM_001025088
NM_001025089
NM_020180
CELF4



CUGBP, Elav-like family member 4



chr6_-_112682459 1.415 NM_001105206
NM_001105207
NM_001105208
NM_001105209
NM_002290
LAMA4




laminin, alpha 4




chr2_+_182029863 1.405 NM_000885
ITGA4
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
chr11_+_24475091 1.400 NM_001009909
LUZP2
leucine zipper protein 2
chr15_+_68971835 1.391 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr3_-_31998241 1.390 NM_001174060
NM_017784
OSBPL10

oxysterol binding protein-like 10

chr10_+_71232281 1.386 COL13A1
collagen, type XIII, alpha 1
chr13_+_113546943 1.384 GAS6
growth arrest-specific 6
chr2_+_54537842 1.379 SPTBN1
spectrin, beta, non-erythrocytic 1
chr1_+_56883333 1.379 NM_006252
PRKAA2
protein kinase, AMP-activated, alpha 2 catalytic subunit
chr4_+_61749540 1.375 LPHN3
latrophilin 3
chr22_+_40800193 1.373 NM_001002034
FAM109B
family with sequence similarity 109, member B
chr5_-_83716346 1.361 NM_005711
EDIL3
EGF-like repeats and discoidin I-like domains 3
chr3_+_44729138 1.360 NM_001134440
NM_001134441
NM_001134442
NM_033210
ZNF502



zinc finger protein 502



chr8_-_23077392 1.352 NM_003840
TNFRSF10D
tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
chr19_+_10900419 1.351 NM_138358
C19orf52
chromosome 19 open reading frame 52
chr6_+_43151922 1.351 NM_002821
NM_152880
NM_152881
NM_152882
PTK7



PTK7 protein tyrosine kinase 7



chr12_-_57600336 1.349 NM_153377
LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr20_+_60810610 1.329 NM_002531
NTSR1
neurotensin receptor 1 (high affinity)
chr2_-_225615556 1.324 NM_014689
DOCK10
dedicator of cytokinesis 10
chr7_-_107883929 1.324 NM_001193582
NM_001193583
NM_001193584
NM_005010
NRCAM



neuronal cell adhesion molecule



chr11_+_128266460 1.316 NM_000890
KCNJ5
potassium inwardly-rectifying channel, subfamily J, member 5
chr3_+_112273352 1.314 PVRL3
poliovirus receptor-related 3
chr17_+_58058783 1.311 MRC2
mannose receptor, C type 2
chr4_-_114901672 1.310 CAMK2D
calcium/calmodulin-dependent protein kinase II delta
chr19_+_61711008 1.309 NM_020813
ZNF471
zinc finger protein 471
chr9_-_128924706 1.307 ANGPTL2
angiopoietin-like 2
chr3_+_157875408 1.303 NM_001184717
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr19_-_51608665 1.296 NM_032040
CCDC8
coiled-coil domain containing 8
chr15_-_21483457 1.295 NDN
necdin homolog (mouse)
chr9_-_25668855 1.293 NM_001004125
TUSC1
tumor suppressor candidate 1
chr11_+_124539768 1.292 NM_022062
PKNOX2
PBX/knotted 1 homeobox 2
chr5_-_92942680 1.282 FLJ42709
hypothetical LOC441094
chr7_+_55054152 1.278 NM_005228
NM_201282
NM_201283
NM_201284
EGFR



epidermal growth factor receptor



chr11_-_27700180 1.261 NM_170731
BDNF
brain-derived neurotrophic factor
chr12_-_47605478 1.254 NM_001143782
NM_016594
FKBP11

FK506 binding protein 11, 19 kDa

chr10_+_53744043 1.249 NM_012242
DKK1
dickkopf homolog 1 (Xenopus laevis)
chrX_-_54538591 1.241 FGD1
FYVE, RhoGEF and PH domain containing 1
chr19_+_61681294 1.234 LOC100128252
hypothetical LOC100128252
chr10_+_88718167 1.231 NM_006829
C10orf116
chromosome 10 open reading frame 116
chr16_-_52877868 1.231 NM_024336
IRX3
iroquois homeobox 3
chr9_-_128924782 1.229 ANGPTL2
angiopoietin-like 2
chr19_+_61681361 1.228 LOC100128252
hypothetical LOC100128252
chr3_+_48482625 1.228 TREX1
three prime repair exonuclease 1
chr10_+_88720477 1.224 NM_133447
AGAP11
ankyrin repeat and GTPase domain Arf GTPase activating protein 11
chr5_-_33927724 1.224 NM_030955
ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr15_-_21483503 1.223 NM_002487
NDN
necdin homolog (mouse)
chr20_-_4177519 1.223 NM_000678
ADRA1D
adrenergic, alpha-1D-, receptor
chr3_+_113060716 1.220 NM_001134438
NM_145753
PHLDB2

pleckstrin homology-like domain, family B, member 2

chr18_-_55515623 1.214 NM_133459
CCBE1
collagen and calcium binding EGF domains 1
chr4_+_156900053 1.214 GUCY1B3
guanylate cyclase 1, soluble, beta 3
chrX_-_3274680 1.214 NM_015419
MXRA5
matrix-remodelling associated 5
chr11_+_46678892 1.210 NM_024741
ZNF408
zinc finger protein 408
chr3_+_113060826 1.210 PHLDB2
pleckstrin homology-like domain, family B, member 2
chr9_+_119506274 1.208 NM_138554
TLR4
toll-like receptor 4
chr5_-_146869613 1.203 DPYSL3
dihydropyrimidinase-like 3
chr14_+_66044958 1.194 GPHN
gephyrin
chr14_+_55654900 1.191 PELI2
pellino homolog 2 (Drosophila)
chr10_-_131652007 1.187 NM_001005463
EBF3
early B-cell factor 3
chr1_+_182622850 1.184 C1orf21
chromosome 1 open reading frame 21
chr9_+_33740463 1.179 NM_001197097
NM_007343
NM_001197098
PRSS3


protease, serine, 3



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.21 7.48e-04 GO:0048518 positive regulation of biological process
1.11 1.06e-03 GO:0050794 regulation of cellular process
1.22 1.38e-03 GO:0048522 positive regulation of cellular process
1.10 1.58e-03 GO:0065007 biological regulation
1.20 1.65e-03 GO:0048731 system development
1.24 2.11e-03 GO:0030154 cell differentiation
1.23 2.46e-03 GO:0048869 cellular developmental process
1.27 3.49e-03 GO:0023051 regulation of signaling
1.28 3.56e-03 GO:0007399 nervous system development
1.17 6.47e-03 GO:0071840 cellular component organization or biogenesis
1.18 7.00e-03 GO:0048856 anatomical structure development
1.17 9.26e-03 GO:0016043 cellular component organization
1.27 9.59e-03 GO:0009966 regulation of signal transduction
1.63 1.02e-02 GO:0030029 actin filament-based process
1.16 1.04e-02 GO:0007275 multicellular organismal development
1.68 1.15e-02 GO:0030036 actin cytoskeleton organization
1.09 1.50e-02 GO:0050789 regulation of biological process
1.15 1.52e-02 GO:0032502 developmental process
1.31 1.74e-02 GO:0010646 regulation of cell communication
1.18 2.08e-02 GO:0071841 cellular component organization or biogenesis at cellular level
1.52 2.10e-02 GO:0010627 regulation of intracellular protein kinase cascade
1.35 2.23e-02 GO:0051128 regulation of cellular component organization
1.54 2.25e-02 GO:0043009 chordate embryonic development
1.52 3.82e-02 GO:0009792 embryo development ending in birth or egg hatching
1.38 4.03e-02 GO:0009790 embryo development
1.18 4.24e-02 GO:0071842 cellular component organization at cellular level

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.50 2.95e-05 GO:0030054 cell junction
1.86 2.19e-04 GO:0031252 cell leading edge
1.94 2.74e-04 GO:0005912 adherens junction
1.89 3.14e-04 GO:0070161 anchoring junction
2.39 1.47e-03 GO:0030426 growth cone
2.02 2.15e-03 GO:0030055 cell-substrate junction
2.32 3.05e-03 GO:0030427 site of polarized growth
1.32 9.49e-03 GO:0042995 cell projection
1.98 1.03e-02 GO:0005925 focal adhesion
1.62 1.16e-02 GO:0016323 basolateral plasma membrane
1.94 1.39e-02 GO:0005924 cell-substrate adherens junction
1.22 1.83e-02 GO:0005856 cytoskeleton
1.05 2.18e-02 GO:0005622 intracellular
1.96 3.81e-02 GO:0001726 ruffle
1.44 4.03e-02 GO:0043005 neuron projection

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.12 2.90e-06 GO:0005515 protein binding
1.55 1.03e-05 GO:0008092 cytoskeletal protein binding
1.59 1.97e-03 GO:0003779 actin binding
1.05 3.14e-02 GO:0005488 binding