Motif ID: SP1.p2

Z-value: 2.131


Transcription factors associated with SP1.p2:

Gene SymbolEntrez IDGene Name
SP1 6667 Sp1 transcription factor



Activity profile for motif SP1.p2.

activity profile for motif SP1.p2


Sorted Z-values histogram for motif SP1.p2

Sorted Z-values for motif SP1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SP1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_55524445 3.583 NM_004977
KCNC3
potassium voltage-gated channel, Shaw-related subfamily, member 3
chr19_+_659766 3.407 NM_001040134
NM_002579
PALM

paralemmin

chr7_-_150305933 2.972 NM_000238
NM_172056
KCNH2

potassium voltage-gated channel, subfamily H (eag-related), member 2

chr7_-_150306169 2.920 KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr7_-_158073121 2.816 NM_002847
NM_130842
NM_130843
PTPRN2


protein tyrosine phosphatase, receptor type, N polypeptide 2


chr20_-_62151216 2.548 NM_018419
SOX18
SRY (sex determining region Y)-box 18
chr19_-_772913 2.515 NM_024888
LPPR3
lipid phosphate phosphatase-related protein type 3
chr14_-_20562962 2.416 NM_201538
NM_201539
NM_201540
NM_201541
NDRG2



NDRG family member 2



chr20_+_61841662 2.414 SLC2A4RG
SLC2A4 regulator
chr19_-_772966 2.289 LPPR3
lipid phosphate phosphatase-related protein type 3
chr22_-_18807805 2.231 PI4KAP2
PI4KAP1
phosphatidylinositol 4-kinase, catalytic, alpha pseudogene 2
phosphatidylinositol 4-kinase, catalytic, alpha pseudogene 1
chr17_+_34114924 2.179 MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr16_-_2186465 2.171 NM_020764
CASKIN1
CASK interacting protein 1
chr19_-_7840806 2.165 FLJ22184
hypothetical protein FLJ22184
chr19_-_2672337 2.135 NM_145173
DIRAS1
DIRAS family, GTP-binding RAS-like 1
chr19_-_60350122 2.106 TNNT1
troponin T type 1 (skeletal, slow)
chr20_+_61841553 2.071 NM_020062
SLC2A4RG
SLC2A4 regulator
chr19_-_60350118 2.069 TNNT1
troponin T type 1 (skeletal, slow)
chr22_+_20101661 2.056 NM_015094
HIC2
hypermethylated in cancer 2
chr1_+_3679168 2.044 NM_001163724
LOC388588
hypothetical protein LOC388588
chr13_-_113066202 2.022 GRTP1
growth hormone regulated TBC protein 1
chr7_-_100078270 1.938 TFR2
transferrin receptor 2
chr9_+_132961723 1.926 AIF1L
allograft inflammatory factor 1-like
chr3_-_47595190 1.858 NM_006574
CSPG5
chondroitin sulfate proteoglycan 5 (neuroglycan C)
chr22_+_21742727 1.841 GNAZ
guanine nucleotide binding protein (G protein), alpha z polypeptide
chr11_+_45900731 1.815 GYLTL1B
glycosyltransferase-like 1B
chr22_+_21742364 1.792 NM_002073
GNAZ
guanine nucleotide binding protein (G protein), alpha z polypeptide
chr17_+_7495140 1.791 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr19_+_59064795 1.780 MYADM
myeloid-associated differentiation marker
chr12_-_21818881 1.773 NM_004982
KCNJ8
potassium inwardly-rectifying channel, subfamily J, member 8
chr20_+_44083667 1.772 NM_001134771
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr22_+_19649417 1.770 NM_001018060
NM_144704
AIFM3

apoptosis-inducing factor, mitochondrion-associated, 3

chr7_-_150283794 1.769 NM_172057
KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr19_-_44503328 1.747


chr1_+_3558958 1.726 NM_005427
TP73
tumor protein p73
chr22_-_21231421 1.718 NM_206955
NM_206956
NM_006115
NM_206953
NM_206954
PRAME




preferentially expressed antigen in melanoma




chr19_+_1397268 1.667 APC2
adenomatosis polyposis coli 2
chr13_-_113066366 1.660 NM_024719
GRTP1
growth hormone regulated TBC protein 1
chr5_-_134397740 1.659 NM_002653
PITX1
paired-like homeodomain 1
chr3_+_185580554 1.654 NM_003741
CHRD
chordin
chr14_-_37134050 1.641 FOXA1
forkhead box A1
chr14_-_37134191 1.632 NM_004496
FOXA1
forkhead box A1
chr20_-_61600834 1.630 NM_001958
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr4_+_995395 1.614 FGFRL1
fibroblast growth factor receptor-like 1
chr6_+_37245860 1.592 NM_002648
PIM1
pim-1 oncogene
chr18_+_586997 1.578 NM_014410
CLUL1
clusterin-like 1 (retinal)
chr16_-_88613287 1.556 NM_001042610
DBNDD1
dysbindin (dystrobrevin binding protein 1) domain containing 1
chr19_+_12805747 1.554 MAST1
microtubule associated serine/threonine kinase 1
chr16_+_1323627 1.550 BAIAP3
BAI1-associated protein 3
chr1_+_30964199 1.549 LOC100129196
hypothetical LOC100129196
chr7_+_5289079 1.547 NM_001040661
NM_153247
SLC29A4

solute carrier family 29 (nucleoside transporters), member 4

chr22_+_18081968 1.539 NM_002688
SEPT5
septin 5
chr17_+_71033339 1.534 NM_001015002
NM_001031803
NM_004524
LLGL2


lethal giant larvae homolog 2 (Drosophila)


chr9_+_132961683 1.530 NM_001185095
NM_001185096
NM_031426
AIF1L


allograft inflammatory factor 1-like


chr13_+_99431417 1.521


chr1_+_945331 1.521 NM_198576
AGRN
agrin
chr22_+_19649460 1.511 AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr14_-_21064182 1.509 SALL2
sal-like 2 (Drosophila)
chr6_+_34312979 1.507 HMGA1
high mobility group AT-hook 1
chr4_+_995609 1.501 NM_001004356
NM_001004358
FGFRL1

fibroblast growth factor receptor-like 1

chr12_+_56230110 1.495 NM_004984
KIF5A
kinesin family member 5A
chr19_-_56585603 1.483 NM_001193623
LOC147646
hypothetical protein LOC147646
chr19_+_12810258 1.477 NM_014975
MAST1
microtubule associated serine/threonine kinase 1
chr6_-_35572694 1.472 NM_003214
TEAD3
TEA domain family member 3
chr19_-_18409788 1.451 NM_001170939
ISYNA1
inositol-3-phosphate synthase 1
chr10_+_134823925 1.450 NM_152643
KNDC1
kinase non-catalytic C-lobe domain (KIND) containing 1
chr9_-_139068269 1.449 NM_001246
NM_203468
ENTPD2

ectonucleoside triphosphate diphosphohydrolase 2

chr10_-_104168890 1.433 NM_002779
PSD
pleckstrin and Sec7 domain containing
chr10_-_135021502 1.428 NM_001098483
NM_198472
C10orf125

chromosome 10 open reading frame 125

chr12_+_56291484 1.427 NM_182947
ARHGEF25
Rho guanine nucleotide exchange factor (GEF) 25
chr11_-_17367439 1.424 NM_001166290
KCNJ11
potassium inwardly-rectifying channel, subfamily J, member 11
chr19_+_10261646 1.415 NM_003259
ICAM5
intercellular adhesion molecule 5, telencephalin
chr16_+_665680 1.411 RHBDL1
rhomboid, veinlet-like 1 (Drosophila)
chr19_-_3431514 1.411 NM_001136503
C19orf77
chromosome 19 open reading frame 77
chr1_-_32574185 1.405 NM_023009
MARCKSL1
MARCKS-like 1
chr16_+_87047159 1.404 ZFPM1
zinc finger protein, multitype 1
chr9_-_122679387 1.385 NM_001009936
NM_015651
PHF19

PHD finger protein 19

chr16_+_620932 1.369 NM_053284
WFIKKN1
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
chr2_+_26249463 1.368 NM_001168241
FAM59B
family with sequence similarity 59, member B
chr19_+_59064471 1.363 NM_001020821
NM_001020818
MYADM

myeloid-associated differentiation marker

chr5_+_176446425 1.355 NM_002011
NM_213647
FGFR4

fibroblast growth factor receptor 4

chr19_-_864138 1.350 C19orf22
chromosome 19 open reading frame 22
chrX_+_138060 1.343 NM_018390
PLCXD1
phosphatidylinositol-specific phospholipase C, X domain containing 1
chr17_+_44429748 1.331 NM_001160423
NM_006546
IGF2BP1

insulin-like growth factor 2 mRNA binding protein 1

chr22_-_17489912 1.326 NM_001173533
NM_001173534
NM_001184781
NM_005137
DGCR2



DiGeorge syndrome critical region gene 2



chr8_-_145187553 1.311 NM_017570
OPLAH
5-oxoprolinase (ATP-hydrolysing)
chr11_+_359723 1.296 NM_178537
B4GALNT4
beta-1,4-N-acetyl-galactosaminyl transferase 4
chr16_+_87765661 1.294 NM_004933
CDH15
cadherin 15, type 1, M-cadherin (myotubule)
chr7_-_100331417 1.293 NM_000665
NM_015831
ACHE

acetylcholinesterase

chr12_+_56230073 1.293 KIF5A
kinesin family member 5A
chr2_+_112372651 1.292 NM_006343
MERTK
c-mer proto-oncogene tyrosine kinase
chr2_+_112372671 1.287 MERTK
c-mer proto-oncogene tyrosine kinase
chr17_-_24077246 1.274 NM_138463
TLCD1
TLC domain containing 1
chr9_+_138726737 1.273 NM_152421
FAM69B
family with sequence similarity 69, member B
chr4_+_2031036 1.270 NM_178557
NAT8L
N-acetyltransferase 8-like (GCN5-related, putative)
chr14_-_37133927 1.269 FOXA1
forkhead box A1
chr11_-_65070625 1.263 LTBP3
latent transforming growth factor beta binding protein 3
chr14_-_20563698 1.262 NDRG2
NDRG family member 2
chr6_+_34313007 1.260 HMGA1
high mobility group AT-hook 1
chr3_-_50315983 1.259 NM_007312
NM_033159
NM_153282
NM_153283
NM_153285
HYAL1




hyaluronoglucosaminidase 1




chr19_+_55398680 1.258 NM_001077186
NM_001145809
NM_024729
MYH14


myosin, heavy chain 14, non-muscle


chr7_-_149101227 1.254 NM_207336
ZNF467
zinc finger protein 467
chr11_+_46359878 1.244 NM_001012333
MDK
midkine (neurite growth-promoting factor 2)
chr22_+_27931685 1.243 NM_133455
EMID1
EMI domain containing 1
chr4_+_1764802 1.242 NM_000142
NM_001163213
NM_022965
FGFR3


fibroblast growth factor receptor 3


chr1_-_203579932 1.242 KLHDC8A
kelch domain containing 8A
chr22_+_21852743 1.241 BCR
breakpoint cluster region
chr5_+_139008052 1.240 CXXC5
CXXC finger protein 5
chr16_+_2016807 1.240 NM_001130012
NM_004785
SLC9A3R2

solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2

chr9_+_129962292 1.228 NM_024112
C9orf16
chromosome 9 open reading frame 16
chr2_-_200030944 1.220 NM_001172509
SATB2
SATB homeobox 2
chr17_+_42283946 1.207 NM_003396
WNT9B
wingless-type MMTV integration site family, member 9B
chr22_+_38183480 1.207 MGAT3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chrX_-_1532648 1.206 NM_001173473
ASMTL
acetylserotonin O-methyltransferase-like
chr17_+_7495436 1.200 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr16_+_54782802 1.197 GNAO1
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
chr1_+_16247870 1.197 NM_001165945
CLCNKB
chloride channel Kb
chr6_+_34312906 1.196 HMGA1
high mobility group AT-hook 1
chr19_-_864224 1.188 NM_138774
C19orf22
chromosome 19 open reading frame 22
chr16_+_1979959 1.185 NM_004209
SYNGR3
synaptogyrin 3
chr11_-_65082208 1.181 NM_001130144
NM_001164266
NM_021070
LTBP3


latent transforming growth factor beta binding protein 3


chr16_+_2461500 1.180 NM_006181
NTN3
netrin 3
chr16_+_65196153 1.178 CMTM3
CKLF-like MARVEL transmembrane domain containing 3
chr7_+_73506333 1.178 NM_005685
GTF2IRD1
GTF2I repeat domain containing 1
chr19_-_864201 1.178 C19orf22
chromosome 19 open reading frame 22
chr22_-_17545872 1.178 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr14_-_64416307 1.177 SPTB
spectrin, beta, erythrocytic
chr20_+_34635362 1.177 NM_021809
TGIF2
TGFB-induced factor homeobox 2
chr12_+_6290127 1.174 PLEKHG6
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
chr19_-_7845325 1.174 NM_001190467
FLJ22184
hypothetical protein FLJ22184
chrX_+_9392980 1.173 NM_005647
TBL1X
transducin (beta)-like 1X-linked
chr2_-_220116508 1.170 NM_024536
CHPF
chondroitin polymerizing factor
chr6_+_7052798 1.168 NM_001168344
RREB1
ras responsive element binding protein 1
chr1_-_44269615 1.166 SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr16_+_88422354 1.165 NM_032451
SPIRE2
spire homolog 2 (Drosophila)
chr19_-_864194 1.160 C19orf22
chromosome 19 open reading frame 22
chr17_-_34015631 1.159 NM_025248
SRCIN1
SRC kinase signaling inhibitor 1
chr2_-_96899396 1.157 NM_017789
SEMA4C
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
chr1_-_2115950 1.154 NM_182533
C1orf86
chromosome 1 open reading frame 86
chr17_-_70401299 1.150 NM_178128
FADS6
fatty acid desaturase domain family, member 6
chr18_+_53253775 1.147 NM_004852
ONECUT2
one cut homeobox 2
chr19_+_868285 1.146 NM_032551
KISS1R
KISS1 receptor
chr20_+_43468046 1.146 NM_001197139
NM_001048221
NM_001048222
NM_001197140
NM_018478
DBNDD2




dysbindin (dystrobrevin binding protein 1) domain containing 2




chrX_+_153318452 1.146 NM_001493
GDI1
GDP dissociation inhibitor 1
chr19_-_864203 1.144 C19orf22
chromosome 19 open reading frame 22
chr20_-_34635091 1.142


chr19_+_1442000 1.142 NM_138393
REEP6
receptor accessory protein 6
chr16_+_87047418 1.129 NM_153813
ZFPM1
zinc finger protein, multitype 1
chr6_-_6632197 1.128


chr9_+_108665168 1.123 NM_021224
ZNF462
zinc finger protein 462
chrX_-_153016368 1.120 NM_001110792
NM_004992
MECP2

methyl CpG binding protein 2 (Rett syndrome)

chr2_+_79593567 1.120 NM_001164883
NM_004389
CTNNA2

catenin (cadherin-associated protein), alpha 2

chr16_+_54782751 1.111 NM_020988
NM_138736
GNAO1

guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O

chr16_+_84202515 1.108 NM_001134473
KIAA0182
KIAA0182
chr6_+_163755773 1.105 QKI
quaking homolog, KH domain RNA binding (mouse)
chr17_-_70480345 1.101


chr10_-_62431203 1.096 RHOBTB1
Rho-related BTB domain containing 1
chr11_+_46359781 1.092 NM_002391
MDK
midkine (neurite growth-promoting factor 2)
chr11_+_46359855 1.091 MDK
midkine (neurite growth-promoting factor 2)
chr22_+_43442987 1.088 NM_001017528
NM_001017529
PRR5

proline rich 5 (renal)

chr14_+_104267270 1.088 NM_199165
ADSSL1
adenylosuccinate synthase like 1
chr9_+_138680064 1.082 EGFL7
EGF-like-domain, multiple 7
chr22_-_17546296 1.081 NM_005984
SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr1_-_21868380 1.081 NM_001145657
NM_002885
RAP1GAP

RAP1 GTPase activating protein

chr8_+_144706699 1.080 NM_001166237
GSDMD
gasdermin D
chr20_-_60484420 1.079 NM_080473
GATA5
GATA binding protein 5
chr20_+_60898249 1.078 NM_018270
C20orf20
chromosome 20 open reading frame 20
chr1_-_40903700 1.077 RIMS3
regulating synaptic membrane exocytosis 3
chr21_-_44583505 1.077 C21orf2
chromosome 21 open reading frame 2
chr22_-_17546276 1.076 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr14_+_104337923 1.071 NM_001137601
ZBTB42
zinc finger and BTB domain containing 42
chr11_-_64268841 1.071 NM_001098670
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr9_+_139619918 1.070 ARRDC1
arrestin domain containing 1
chr2_-_70848621 1.067 NM_001185055
NM_001617
NM_017482
NM_017488
ADD2



adducin 2 (beta)



chr16_-_960982 1.067 NM_022773
LMF1
lipase maturation factor 1
chr16_-_1862162 1.061 NM_001163560
C16orf73
chromosome 16 open reading frame 73
chr1_+_945399 1.059


chr4_-_115120251 1.059 NM_024590
ARSJ
arylsulfatase family, member J
chr10_-_104168559 1.056 PSD
pleckstrin and Sec7 domain containing
chr12_+_56230047 1.056 KIF5A
kinesin family member 5A
chr20_+_56900116 1.055 NM_001077488
GNAS
GNAS complex locus
chr20_-_60963390 1.054 NM_006602
TCFL5
transcription factor-like 5 (basic helix-loop-helix)
chr17_-_30783631 1.053 NM_018042
SLFN12
schlafen family member 12
chr19_-_48835783 1.053 NM_145296
CADM4
cell adhesion molecule 4
chr11_-_64269501 1.049 NM_153819
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr19_-_60557875 1.047 NM_144613
COX6B2
cytochrome c oxidase subunit VIb polypeptide 2 (testis)
chr17_+_26839143 1.046 RAB11FIP4
RAB11 family interacting protein 4 (class II)
chr19_-_1441403 1.045 NM_017573
PCSK4
proprotein convertase subtilisin/kexin type 4
chr7_+_150390566 1.044 SLC4A2
solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)
chr19_+_7891193 1.043 NM_003083
SNAPC2
small nuclear RNA activating complex, polypeptide 2, 45kDa
chr22_-_17546234 1.041 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr20_+_60246972 1.041 NM_014835
NM_144498
OSBPL2

oxysterol binding protein-like 2

chrX_+_152561086 1.034 NM_001395
DUSP9
dual specificity phosphatase 9
chr17_+_75366524 1.031 NM_005189
NM_032647
CBX2

chromobox homolog 2

chr19_-_54636425 1.025 NM_020309
SLC17A7
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
chr6_-_31977747 1.025 NM_181842
ZBTB12
zinc finger and BTB domain containing 12
chr11_+_61032847 1.024 NM_001145077
LRRC10B
leucine rich repeat containing 10B
chr6_+_169866714 1.024 LOC729088
hypothetical LOC729088
chr17_-_73636386 1.021 NM_001127198
TMC6
transmembrane channel-like 6
chr12_+_6290359 1.018 NM_001144856
PLEKHG6
pleckstrin homology domain containing, family G (with RhoGef domain) member 6

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.08 3.37e-28 GO:0009987 cellular process
1.13 2.18e-23 GO:0044237 cellular metabolic process
1.16 7.56e-23 GO:0044260 cellular macromolecule metabolic process
1.18 2.30e-18 GO:0060255 regulation of macromolecule metabolic process
1.17 6.63e-18 GO:0031323 regulation of cellular metabolic process
1.17 8.06e-18 GO:0080090 regulation of primary metabolic process
1.10 9.55e-17 GO:0008152 metabolic process
1.15 2.00e-16 GO:0019222 regulation of metabolic process
1.10 1.33e-15 GO:0050794 regulation of cellular process
1.13 3.52e-15 GO:0043170 macromolecule metabolic process
1.11 3.61e-15 GO:0044238 primary metabolic process
1.20 4.64e-15 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.19 5.64e-15 GO:0010468 regulation of gene expression
1.09 5.94e-15 GO:0065007 biological regulation
1.18 3.48e-14 GO:0071842 cellular component organization at cellular level
1.50 3.73e-14 GO:0016568 chromatin modification
1.19 6.91e-14 GO:0010556 regulation of macromolecule biosynthetic process
1.09 1.12e-13 GO:0050789 regulation of biological process
1.19 3.17e-13 GO:0051252 regulation of RNA metabolic process
1.23 4.84e-13 GO:0006996 organelle organization
1.17 9.37e-13 GO:0071841 cellular component organization or biogenesis at cellular level
1.17 2.12e-12 GO:0051171 regulation of nitrogen compound metabolic process
1.17 6.60e-12 GO:0031326 regulation of cellular biosynthetic process
1.17 9.40e-12 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.17 1.02e-11 GO:0009889 regulation of biosynthetic process
1.14 1.10e-11 GO:0016043 cellular component organization
1.19 1.20e-11 GO:0006355 regulation of transcription, DNA-dependent
1.16 2.10e-11 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.28 4.47e-11 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.15 5.90e-11 GO:0034641 cellular nitrogen compound metabolic process
1.18 6.37e-11 GO:0090304 nucleic acid metabolic process
1.13 2.72e-10 GO:0071840 cellular component organization or biogenesis
1.61 3.40e-10 GO:0016569 covalent chromatin modification
1.14 3.81e-10 GO:0006807 nitrogen compound metabolic process
1.16 4.25e-10 GO:0044267 cellular protein metabolic process
1.26 4.30e-10 GO:0007049 cell cycle
1.61 4.32e-10 GO:0016570 histone modification
1.20 7.61e-10 GO:0016070 RNA metabolic process
1.28 8.03e-10 GO:0010605 negative regulation of macromolecule metabolic process
1.19 1.04e-09 GO:0006464 protein modification process
1.17 5.37e-09 GO:0048523 negative regulation of cellular process
1.18 7.05e-09 GO:0043412 macromolecule modification
1.33 9.98e-09 GO:0010629 negative regulation of gene expression
1.14 1.94e-08 GO:0048518 positive regulation of biological process
1.15 1.99e-08 GO:0048522 positive regulation of cellular process
1.31 2.54e-08 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.36 3.02e-08 GO:0006325 chromatin organization
1.25 3.59e-08 GO:0009892 negative regulation of metabolic process
1.33 5.05e-08 GO:0045892 negative regulation of transcription, DNA-dependent
1.27 5.40e-08 GO:0022402 cell cycle process
1.15 5.83e-08 GO:0048519 negative regulation of biological process
1.38 9.80e-08 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.15 1.04e-07 GO:0044249 cellular biosynthetic process
1.32 1.16e-07 GO:0051253 negative regulation of RNA metabolic process
1.30 1.22e-07 GO:0010558 negative regulation of macromolecule biosynthetic process
1.28 2.54e-07 GO:0022403 cell cycle phase
1.23 2.67e-07 GO:0032268 regulation of cellular protein metabolic process
1.25 3.22e-07 GO:0031324 negative regulation of cellular metabolic process
1.22 3.23e-07 GO:0051246 regulation of protein metabolic process
1.30 3.59e-07 GO:0051276 chromosome organization
1.14 9.02e-07 GO:0009058 biosynthetic process
1.29 1.65e-06 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.28 2.36e-06 GO:0051172 negative regulation of nitrogen compound metabolic process
1.16 2.54e-06 GO:0010467 gene expression
1.27 2.77e-06 GO:0009890 negative regulation of biosynthetic process
1.17 3.84e-06 GO:0034645 cellular macromolecule biosynthetic process
1.23 4.74e-06 GO:0006351 transcription, DNA-dependent
1.29 5.08e-06 GO:0000278 mitotic cell cycle
1.17 6.89e-06 GO:0023051 regulation of signaling
1.26 8.84e-06 GO:0031327 negative regulation of cellular biosynthetic process
1.16 9.93e-06 GO:0009059 macromolecule biosynthetic process
1.21 2.22e-05 GO:0032774 RNA biosynthetic process
1.12 2.36e-05 GO:0019538 protein metabolic process
1.17 2.83e-05 GO:0009966 regulation of signal transduction
1.16 6.94e-05 GO:0007399 nervous system development
1.27 1.92e-04 GO:0006974 response to DNA damage stimulus
1.22 3.63e-04 GO:0031399 regulation of protein modification process
1.18 3.84e-04 GO:0010604 positive regulation of macromolecule metabolic process
1.20 8.64e-04 GO:0033554 cellular response to stress
1.39 1.03e-03 GO:0048011 nerve growth factor receptor signaling pathway
1.23 1.57e-03 GO:0051726 regulation of cell cycle
1.36 1.63e-03 GO:0051248 negative regulation of protein metabolic process
1.17 1.67e-03 GO:0031325 positive regulation of cellular metabolic process
1.16 2.34e-03 GO:0009893 positive regulation of metabolic process
1.36 2.48e-03 GO:0032269 negative regulation of cellular protein metabolic process
1.30 2.76e-03 GO:0051301 cell division
1.27 2.87e-03 GO:0000279 M phase
1.58 5.52e-03 GO:0018205 peptidyl-lysine modification
1.18 5.68e-03 GO:0022008 neurogenesis
1.62 5.79e-03 GO:0007173 epidermal growth factor receptor signaling pathway
1.65 7.13e-03 GO:0006475 internal protein amino acid acetylation
1.24 7.52e-03 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.31 8.05e-03 GO:0048285 organelle fission
1.22 8.57e-03 GO:0009057 macromolecule catabolic process
1.16 9.13e-03 GO:0010646 regulation of cell communication
1.61 9.42e-03 GO:0006473 protein acetylation
1.30 1.06e-02 GO:0000087 M phase of mitotic cell cycle
1.64 1.18e-02 GO:0018394 peptidyl-lysine acetylation
1.52 1.23e-02 GO:0040029 regulation of gene expression, epigenetic
1.49 1.44e-02 GO:0042770 signal transduction in response to DNA damage
1.08 1.53e-02 GO:0032502 developmental process
1.29 1.56e-02 GO:0070647 protein modification by small protein conjugation or removal
1.23 1.75e-02 GO:0000904 cell morphogenesis involved in differentiation
1.21 1.89e-02 GO:0000902 cell morphogenesis
1.63 1.95e-02 GO:0018393 internal peptidyl-lysine acetylation
1.18 2.02e-02 GO:0048699 generation of neurons
1.29 2.16e-02 GO:0006511 ubiquitin-dependent protein catabolic process
1.23 2.18e-02 GO:0007010 cytoskeleton organization
1.16 2.25e-02 GO:0006793 phosphorus metabolic process
1.16 2.25e-02 GO:0006796 phosphate metabolic process
1.13 2.43e-02 GO:0065009 regulation of molecular function
1.89 2.45e-02 GO:0034968 histone lysine methylation
1.29 2.67e-02 GO:0051325 interphase
1.40 2.76e-02 GO:0031400 negative regulation of protein modification process
1.23 2.77e-02 GO:0048858 cell projection morphogenesis
1.29 2.97e-02 GO:0000280 nuclear division
1.29 2.97e-02 GO:0007067 mitosis
1.27 3.15e-02 GO:0018193 peptidyl-amino acid modification
1.62 3.19e-02 GO:0016573 histone acetylation
1.29 3.31e-02 GO:0051329 interphase of mitotic cell cycle
1.20 3.67e-02 GO:0007167 enzyme linked receptor protein signaling pathway
1.28 4.00e-02 GO:0019941 modification-dependent protein catabolic process
1.24 4.32e-02 GO:0048812 neuron projection morphogenesis
1.20 4.42e-02 GO:0030030 cell projection organization
1.08 4.47e-02 GO:0007275 multicellular organismal development
1.53 4.82e-02 GO:0043543 protein acylation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.11 8.62e-67 GO:0044424 intracellular part
1.11 1.05e-65 GO:0005622 intracellular
1.14 3.69e-54 GO:0043227 membrane-bounded organelle
1.14 9.24e-54 GO:0043231 intracellular membrane-bounded organelle
1.12 2.96e-52 GO:0043229 intracellular organelle
1.12 5.44e-52 GO:0043226 organelle
1.17 1.65e-38 GO:0005634 nucleus
1.11 1.69e-31 GO:0005737 cytoplasm
1.15 9.62e-27 GO:0044446 intracellular organelle part
1.14 1.89e-26 GO:0044422 organelle part
1.25 2.77e-24 GO:0044428 nuclear part
1.13 4.31e-22 GO:0044444 cytoplasmic part
1.26 1.13e-21 GO:0031981 nuclear lumen
1.21 2.27e-18 GO:0070013 intracellular organelle lumen
1.21 4.40e-18 GO:0031974 membrane-enclosed lumen
1.20 4.79e-17 GO:0043233 organelle lumen
1.22 7.36e-17 GO:0005829 cytosol
1.24 8.33e-13 GO:0005654 nucleoplasm
1.03 2.50e-12 GO:0044464 cell part
1.03 2.91e-12 GO:0005623 cell
1.31 1.51e-11 GO:0044451 nucleoplasm part
1.14 4.97e-10 GO:0043234 protein complex
1.12 1.73e-09 GO:0032991 macromolecular complex
1.14 4.19e-09 GO:0043228 non-membrane-bounded organelle
1.14 4.19e-09 GO:0043232 intracellular non-membrane-bounded organelle
1.27 1.76e-07 GO:0015630 microtubule cytoskeleton
1.29 7.38e-07 GO:0005694 chromosome
1.16 2.20e-06 GO:0012505 endomembrane system
1.82 1.27e-05 GO:0034708 methyltransferase complex
1.82 1.27e-05 GO:0035097 histone methyltransferase complex
1.60 9.67e-05 GO:0016585 chromatin remodeling complex
1.18 9.80e-05 GO:0005783 endoplasmic reticulum
1.26 1.11e-04 GO:0005730 nucleolus
1.12 1.76e-04 GO:0031090 organelle membrane
1.26 2.25e-04 GO:0044427 chromosomal part
1.32 6.61e-04 GO:0005874 microtubule
1.35 1.78e-03 GO:0000228 nuclear chromosome
1.74 4.35e-03 GO:0000792 heterochromatin
1.37 4.69e-03 GO:0044454 nuclear chromosome part
1.60 6.06e-03 GO:0000123 histone acetyltransferase complex
1.27 6.12e-03 GO:0005815 microtubule organizing center
2.07 7.46e-03 GO:0031519 PcG protein complex
1.17 8.96e-03 GO:0044432 endoplasmic reticulum part
1.35 9.03e-03 GO:0005819 spindle
1.52 1.11e-02 GO:0000790 nuclear chromatin
1.30 1.15e-02 GO:0005667 transcription factor complex
1.25 1.44e-02 GO:0048471 perinuclear region of cytoplasm
1.74 1.58e-02 GO:0000118 histone deacetylase complex
1.18 1.63e-02 GO:0005789 endoplasmic reticulum membrane
1.15 1.99e-02 GO:0005794 Golgi apparatus
1.17 2.69e-02 GO:0042175 nuclear membrane-endoplasmic reticulum network
1.28 4.16e-02 GO:0000785 chromatin

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.13 3.35e-35 GO:0005515 protein binding
1.07 9.72e-26 GO:0005488 binding
1.10 2.62e-11 GO:0003824 catalytic activity
1.14 6.92e-11 GO:0003676 nucleic acid binding
1.26 1.19e-10 GO:0030528 transcription regulator activity
1.16 1.41e-09 GO:0003677 DNA binding
1.28 1.25e-08 GO:0019899 enzyme binding
1.38 2.23e-08 GO:0000988 protein binding transcription factor activity
1.38 2.23e-08 GO:0000989 transcription factor binding transcription factor activity
1.38 3.11e-08 GO:0003712 transcription cofactor activity
1.14 2.36e-07 GO:0000166 nucleotide binding
1.35 4.12e-05 GO:0016564 transcription repressor activity
1.15 4.55e-05 GO:0032559 adenyl ribonucleotide binding
1.15 6.04e-05 GO:0030554 adenyl nucleotide binding
1.15 6.62e-05 GO:0005524 ATP binding
1.14 9.12e-05 GO:0035639 purine ribonucleoside triphosphate binding
1.13 9.34e-05 GO:0032553 ribonucleotide binding
1.13 9.34e-05 GO:0032555 purine ribonucleotide binding
1.14 1.09e-04 GO:0016740 transferase activity
1.13 1.18e-04 GO:0017076 purine nucleotide binding
1.28 2.22e-04 GO:0019904 protein domain specific binding
1.19 2.70e-04 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.18 5.25e-04 GO:0001071 nucleic acid binding transcription factor activity
1.18 5.25e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
1.11 7.01e-04 GO:0046914 transition metal ion binding
1.08 8.17e-04 GO:0043169 cation binding
1.08 8.57e-04 GO:0043167 ion binding
1.12 1.01e-03 GO:0008270 zinc ion binding
1.32 1.07e-03 GO:0008134 transcription factor binding
1.08 1.11e-03 GO:0046872 metal ion binding
1.19 1.20e-03 GO:0016301 kinase activity
1.39 1.25e-03 GO:0003682 chromatin binding
1.84 2.06e-03 GO:0018024 histone-lysine N-methyltransferase activity
1.35 2.21e-03 GO:0003713 transcription coactivator activity
1.30 3.56e-03 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.32 4.11e-03 GO:0003702 RNA polymerase II transcription factor activity
1.24 4.89e-03 GO:0016874 ligase activity
1.19 6.37e-03 GO:0043565 sequence-specific DNA binding
1.19 7.64e-03 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.41 8.59e-03 GO:0003714 transcription corepressor activity
1.75 1.79e-02 GO:0016278 lysine N-methyltransferase activity
1.75 1.79e-02 GO:0016279 protein-lysine N-methyltransferase activity
1.52 2.90e-02 GO:0031625 ubiquitin protein ligase binding
1.67 3.01e-02 GO:0042054 histone methyltransferase activity
1.33 3.35e-02 GO:0010843 promoter binding
1.30 3.43e-02 GO:0019787 small conjugating protein ligase activity
1.25 4.72e-02 GO:0016563 transcription activator activity