Motif ID: PRDM1.p3

Z-value: 2.877


Transcription factors associated with PRDM1.p3:

Gene SymbolEntrez IDGene Name
PRDM1 639 PR domain containing 1, with ZNF domain



Activity profile for motif PRDM1.p3.

activity profile for motif PRDM1.p3


Sorted Z-values histogram for motif PRDM1.p3

Sorted Z-values for motif PRDM1.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of PRDM1.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_16717887 10.633 BNC2
basonuclin 2
chr6_-_112682401 8.153 LAMA4
laminin, alpha 4
chr6_-_112682459 7.496 NM_001105206
NM_001105207
NM_001105208
NM_001105209
NM_002290
LAMA4




laminin, alpha 4




chr10_-_44200458 7.261 NM_000609
NM_001033886
NM_001178134
NM_199168
CXCL12



chemokine (C-X-C motif) ligand 12



chr6_-_112682038 7.109 LAMA4
laminin, alpha 4
chr11_-_104344473 6.750 NM_001225
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr16_+_55580910 6.495 NM_032206
NLRC5
NLR family, CARD domain containing 5
chr4_+_142777172 6.204 NM_000585
NM_172174
IL15

interleukin 15

chr6_-_112682573 6.141 LAMA4
laminin, alpha 4
chr3_-_115825742 5.704 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr17_+_6600080 5.364 XAF1
XIAP associated factor 1
chr8_-_79880095 4.732 NM_000880
IL7
interleukin 7
chr4_+_14985272 4.705 NM_001135171
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr2_-_189752575 4.626 NM_000393
COL5A2
collagen, type V, alpha 2
chr4_+_187227302 4.489 NM_003265
TLR3
toll-like receptor 3
chr11_-_85107569 4.441 NM_206929
SYTL2
synaptotagmin-like 2
chr17_+_6599879 4.094 NM_017523
NM_199139
XAF1

XIAP associated factor 1

chr4_+_37569093 4.076 NM_015173
TBC1D1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr6_+_127481740 4.052 NM_032784
RSPO3
R-spondin 3 homolog (Xenopus laevis)
chr8_+_134272463 3.946 NM_003882
NM_080838
WISP1

WNT1 inducible signaling pathway protein 1

chr1_-_111548440 3.894 DENND2D
DENN/MADD domain containing 2D
chr22_-_34886727 3.882 NM_145640
APOL3
apolipoprotein L, 3
chr17_+_3326045 3.525 NM_000049
ASPA
aspartoacylase
chr12_+_6431437 3.477 NM_018009
TAPBPL
TAP binding protein-like
chr22_-_28972683 3.445 NM_002309
LIF
leukemia inhibitory factor (cholinergic differentiation factor)
chr9_+_108665168 3.439 NM_021224
ZNF462
zinc finger protein 462
chr6_+_127481496 3.437 RSPO3
R-spondin 3 homolog (Xenopus laevis)
chr11_-_40272239 3.410 NM_020929
LRRC4C
leucine rich repeat containing 4C
chr1_+_160868932 3.330 DDR2
discoidin domain receptor tyrosine kinase 2
chr1_+_2975590 3.236 NM_022114
NM_199454
PRDM16

PR domain containing 16

chr10_-_131652007 3.236 NM_001005463
EBF3
early B-cell factor 3
chr4_+_146623405 3.152 NM_001003688
SMAD1
SMAD family member 1
chrX_-_62921937 3.081 NM_001173479
ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr10_+_63478974 2.994 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr8_-_23596346 2.973 NM_006167
NKX3-1
NK3 homeobox 1
chr11_+_32069183 2.900 RCN1
reticulocalbin 1, EF-hand calcium binding domain
chr8_+_144711619 2.862 NM_024736
GSDMD
gasdermin D
chr8_-_145132551 2.847 PARP10
poly (ADP-ribose) polymerase family, member 10
chr20_+_13924014 2.844 NM_080676
MACROD2
MACRO domain containing 2
chr2_-_19421852 2.791 NM_145260
OSR1
odd-skipped related 1 (Drosophila)
chr3_-_49826221 2.767 UBA7
ubiquitin-like modifier activating enzyme 7
chr20_+_56904042 2.766 GNAS
GNAS complex locus
chr10_+_18469611 2.763 NM_201593
NM_201596
NM_201597
NM_001167945
NM_201571
NM_201572
CACNB2





calcium channel, voltage-dependent, beta 2 subunit





chr8_-_145132582 2.671 NM_032789
PARP10
poly (ADP-ribose) polymerase family, member 10
chr20_+_13924263 2.629 MACROD2
MACRO domain containing 2
chr21_+_25856311 2.580 MIR155HG
MIR155 host gene (non-protein coding)
chr1_+_160868822 2.556 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr4_-_153523113 2.511 NM_001013415
FBXW7
F-box and WD repeat domain containing 7
chr10_+_114125955 2.509 ACSL5
acyl-CoA synthetase long-chain family member 5
chr15_-_53996597 2.488 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr3_-_49826360 2.477 NM_003335
UBA7
ubiquitin-like modifier activating enzyme 7
chr10_+_114126004 2.438 ACSL5
acyl-CoA synthetase long-chain family member 5
chr17_+_17339059 2.415


chr10_+_114125927 2.357 NM_016234
ACSL5
acyl-CoA synthetase long-chain family member 5
chr21_-_34820916 2.346 NM_203418
RCAN1
regulator of calcineurin 1
chr17_-_45626364 2.177


chr11_-_40271086 2.138 LRRC4C
leucine rich repeat containing 4C
chr3_+_8518539 2.094 LMCD1
LIM and cysteine-rich domains 1
chr3_-_189354510 2.067 LOC339929
hypothetical LOC339929
chr6_-_105691235 2.001 NM_007073
BVES
blood vessel epicardial substance
chr3_+_189354167 1.999 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr11_+_63060848 1.944 NM_004585
RARRES3
retinoic acid receptor responder (tazarotene induced) 3
chr3_+_120495906 1.938 NM_020754
ARHGAP31
Rho GTPase activating protein 31
chr6_-_105691675 1.811 BVES
blood vessel epicardial substance
chr5_-_142795269 1.770 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr19_+_40931285 1.767 NM_019104
LIN37
lin-37 homolog (C. elegans)
chr21_-_42219849 1.748 NM_199050
C2CD2
C2 calcium-dependent domain containing 2
chr3_+_8518508 1.747 NM_014583
LMCD1
LIM and cysteine-rich domains 1
chr9_+_136673464 1.718 NM_000093
COL5A1
collagen, type V, alpha 1
chr4_-_100461530 1.660 NM_000668
ADH1B
alcohol dehydrogenase 1B (class I), beta polypeptide
chr7_-_92301147 1.618 NM_001259
CDK6
cyclin-dependent kinase 6
chr15_-_40537002 1.615 NM_022473
ZFP106
zinc finger protein 106 homolog (mouse)
chr9_-_8723893 1.578 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
PTPRD




protein tyrosine phosphatase, receptor type, D




chr6_-_32919751 1.551 NM_148919
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr12_+_120055013 1.511 NM_002562
P2RX7
purinergic receptor P2X, ligand-gated ion channel, 7
chr9_+_18464138 1.494 ADAMTSL1
ADAMTS-like 1
chr20_-_5048443 1.450 NM_182649
PCNA
proliferating cell nuclear antigen
chr10_+_91082218 1.444 NM_001031683
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr20_+_56903595 1.422 GNAS
GNAS complex locus
chr11_-_104411065 1.345 NM_001223
NM_033292
NM_033293
NM_033294
NM_033295
CASP1




caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)




chr14_-_68329407 1.345 NM_004926
ZFP36L1
zinc finger protein 36, C3H type-like 1
chr19_-_52427698 1.321 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr5_+_49998528 1.318 NM_001178056
NM_024615
PARP8

poly (ADP-ribose) polymerase family, member 8

chr3_-_8518327 1.303 LOC100288428
hypothetical LOC100288428
chr5_+_140411144 1.282 NM_013340
PCDHB1
protocadherin beta 1
chr8_-_23768242 1.253 NM_003155
STC1
stanniocalcin 1
chr3_+_176059763 1.250 NM_207015
NAALADL2
N-acetylated alpha-linked acidic dipeptidase-like 2
chr1_+_110254979 1.222 CSF1
colony stimulating factor 1 (macrophage)
chr8_+_97575071 1.221 SDC2
syndecan 2
chr3_-_11598829 1.213 NM_001128220
VGLL4
vestigial like 4 (Drosophila)
chr19_-_23370066 1.174 NM_003430
ZNF91
zinc finger protein 91
chr2_+_230900121 1.171 NM_138402
SP140L
SP140 nuclear body protein-like
chr11_+_5602782 1.154 NM_021616
TRIM34
tripartite motif containing 34
chr2_+_230989177 1.144 SP100
SP100 nuclear antigen
chr2_+_230989114 1.126 NM_001080391
NM_003113
SP100

SP100 nuclear antigen

chr11_-_85108030 1.115 NM_001162952
NM_206930
SYTL2

synaptotagmin-like 2

chr1_-_197173159 1.114 LOC100131234
familial acute myelogenous leukemia related factor
chr8_-_93144366 1.099 NM_004349
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr13_+_107719977 1.098 NM_001145645
NM_006573
TNFSF13B

tumor necrosis factor (ligand) superfamily, member 13b

chr12_+_11694172 1.093 ETV6
ets variant 6
chr2_+_205118801 1.084 PARD3B
par-3 partitioning defective 3 homolog B (C. elegans)
chr15_+_68971835 1.060 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr17_+_75851984 1.037


chr8_+_97575052 1.007 NM_002998
SDC2
syndecan 2
chr11_+_58668827 1.006 NM_022074
NM_198847
FAM111A

family with sequence similarity 111, member A

chr9_+_111582317 0.991 NM_053016
NM_007203
NM_147150
PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr16_-_71650034 0.976 NM_001164766
ZFHX3
zinc finger homeobox 3
chr13_+_30207690 0.946 ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr8_-_29176490 0.935 NM_015254
KIF13B
kinesin family member 13B
chr9_+_119506428 0.910 TLR4
toll-like receptor 4
chr8_+_97575196 0.908 SDC2
syndecan 2
chr2_+_205118961 0.898 PARD3B
par-3 partitioning defective 3 homolog B (C. elegans)
chr10_+_91051685 0.898 NM_001547
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr21_-_38955487 0.883 NM_001136154
NM_004449
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr8_+_97575244 0.853 SDC2
syndecan 2
chr6_+_30018287 0.842 NM_002116
HLA-A
major histocompatibility complex, class I, A
chr13_-_109600709 0.827 COL4A1
collagen, type IV, alpha 1
chr6_+_32919873 0.820


chrX_-_106248706 0.799 NM_001171080
NM_018301
RBM41

RNA binding motif protein 41

chr14_+_101297887 0.785 NM_001161725
NM_001161726
PPP2R5C

protein phosphatase 2, regulatory subunit B', gamma

chr8_-_42184350 0.775 NM_000930
NM_033011
PLAT

plasminogen activator, tissue

chr7_+_134114957 0.745 CALD1
caldesmon 1
chr13_+_30207668 0.732 NM_001629
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr10_-_97311084 0.722 NM_015385
NM_024991
SORBS1

sorbin and SH3 domain containing 1

chr7_+_134114701 0.704 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr12_-_47605478 0.700 NM_001143782
NM_016594
FKBP11

FK506 binding protein 11, 19 kDa

chr2_+_205118710 0.691 NM_057177
NM_152526
NM_205863
PARD3B


par-3 partitioning defective 3 homolog B (C. elegans)


chr22_-_30018329 0.685 NM_001135911
NM_052880
PIK3IP1

phosphoinositide-3-kinase interacting protein 1

chr6_+_32929902 0.655 NM_002800
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
chr14_+_23675206 0.655 NM_006263
NM_176783
PSME1

proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)

chr7_+_89681069 0.648 NM_001040666
STEAP2
six transmembrane epithelial antigen of the prostate 2
chr17_-_35774467 0.648 NM_152219
GJD3
gap junction protein, delta 3, 31.9kDa
chr14_+_23675233 0.647 PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr11_+_93501811 0.647 PANX1
pannexin 1
chr1_-_242073094 0.640 NM_005465
NM_181690
AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

chr1_-_2486313 0.617 NM_003820
TNFRSF14
tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
chr17_+_38412267 0.616 NM_005533
IFI35
interferon-induced protein 35
chr2_-_230792844 0.615 NM_004509
NM_004510
NM_080424
SP110


SP110 nuclear body protein


chr9_-_116608113 0.614 NM_005118
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
chr10_+_69539255 0.610 NM_032578
MYPN
myopalladin
chr15_-_78050515 0.609 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr6_-_28663045 0.603 NM_052923
SCAND3
SCAN domain containing 3
chr7_+_134483305 0.571 NM_018295
TMEM140
transmembrane protein 140
chr2_-_224611568 0.570 NM_001136530
SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr13_+_107720206 0.569 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chrX_+_102770547 0.554 NM_001006639
NM_004780
TCEAL1

transcription elongation factor A (SII)-like 1

chr5_-_16670085 0.545 NM_001034850
FAM134B
family with sequence similarity 134, member B
chr19_+_20138991 0.539 NM_052852
ZNF486
zinc finger protein 486
chr4_+_86918882 0.531 ARHGAP24
Rho GTPase activating protein 24
chr11_+_71387572 0.528 NM_001039659
NM_001039660
NM_173042
IL18BP


interleukin 18 binding protein


chr9_+_33785558 0.520 NM_002771
PRSS3
protease, serine, 3
chr1_-_152847256 0.517 ADAR
adenosine deaminase, RNA-specific
chr15_+_72620570 0.511 NM_006465
ARID3B
AT rich interactive domain 3B (BRIGHT-like)
chr3_-_102888090 0.497 NM_000986
RPL24
ribosomal protein L24
chr15_+_65245546 0.487 NM_001145104
SMAD3
SMAD family member 3
chr9_+_119506446 0.484 TLR4
toll-like receptor 4
chr11_-_786175 0.482 NM_024698
SLC25A22
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
chr19_+_54669629 0.477 FLT3LG
fms-related tyrosine kinase 3 ligand
chr6_-_101018271 0.477 NM_005068
SIM1
single-minded homolog 1 (Drosophila)
chr1_+_158063130 0.469 SLAMF8
SLAM family member 8
chr1_-_159435440 0.465 NM_005099
ADAMTS4
ADAM metallopeptidase with thrombospondin type 1 motif, 4
chr12_+_100795480 0.459 DRAM1
DNA-damage regulated autophagy modulator 1
chr2_+_3605611 0.456 RPS7
ribosomal protein S7
chr1_+_158063102 0.456 NM_020125
SLAMF8
SLAM family member 8
chr8_+_96215144 0.456 PLEKHF2
pleckstrin homology domain containing, family F (with FYVE domain) member 2
chr13_+_107720475 0.443 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr5_+_152850276 0.434 NM_000827
NM_001114183
GRIA1

glutamate receptor, ionotropic, AMPA 1

chr2_+_230989150 0.430 SP100
SP100 nuclear antigen
chrX_-_106248674 0.428 RBM41
RNA binding motif protein 41
chr6_-_25044156 0.419 FAM65B
family with sequence similarity 65, member B
chr8_-_42184194 0.418 PLAT
plasminogen activator, tissue
chr8_-_41641881 0.418 NM_001142445
NM_020478
NM_020480
ANK1


ankyrin 1, erythrocytic


chrX_+_102770303 0.411 NM_001006640
TCEAL1
transcription elongation factor A (SII)-like 1
chr3_-_113495763 0.401 NM_183061
SLC9A10
solute carrier family 9, member 10
chr4_-_177160474 0.398 GPM6A
glycoprotein M6A
chr14_+_23771464 0.398 NM_001002000
NM_001002001
GMPR2

guanosine monophosphate reductase 2

chr10_+_92970487 0.395 PCGF5
polycomb group ring finger 5
chr2_+_6935246 0.394 NM_080657
RSAD2
radical S-adenosyl methionine domain containing 2
chr10_+_122600843 0.369 WDR11
WD repeat domain 11
chr1_-_152847301 0.368 NM_001111
NM_015840
NM_015841
ADAR


adenosine deaminase, RNA-specific


chr12_-_54996098 0.366 NM_001190991
NM_014255
CNPY2

canopy 2 homolog (zebrafish)

chr22_+_37747063 0.350 NM_152426
APOBEC3D
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D
chr11_-_85015961 0.344 NM_001142699
DLG2
discs, large homolog 2 (Drosophila)
chr6_+_116889248 0.336 NM_001010919
FAM26F
family with sequence similarity 26, member F
chr3_-_69212192 0.317 NM_003968
NM_198195
UBA3

ubiquitin-like modifier activating enzyme 3

chr11_-_92570693 0.316 NM_152313
SLC36A4
solute carrier family 36 (proton/amino acid symporter), member 4
chr12_+_27511009 0.315 NM_001145010
C12orf70
chromosome 12 open reading frame 70
chr17_+_29621352 0.312 NM_006273
CCL7
chemokine (C-C motif) ligand 7
chr6_-_32920167 0.312 PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr12_-_66839589 0.308 NM_000619
IFNG
interferon, gamma
chr2_+_96672200 0.301 NM_001113382
FER1L5
fer-1-like 5 (C. elegans)
chr14_-_23981493 0.295 NM_020195
SDR39U1
short chain dehydrogenase/reductase family 39U, member 1
chr21_+_36364168 0.294 CBR1
carbonyl reductase 1
chr2_+_17585287 0.293 NM_003385
VSNL1
visinin-like 1
chr2_+_17585462 0.290 VSNL1
visinin-like 1
chr10_-_13789628 0.288 FRMD4A
FERM domain containing 4A
chr1_+_149638633 0.287 NM_002796
PSMB4
proteasome (prosome, macropain) subunit, beta type, 4
chr7_-_86686754 0.285 NM_024315
C7orf23
chromosome 7 open reading frame 23
chr10_+_91077581 0.274 NM_001549
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr14_-_23685629 0.265 NM_002818
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
10.39 2.11e-04 GO:0060337 type I interferon-mediated signaling pathway
10.39 2.11e-04 GO:0071357 cellular response to type I interferon
10.22 2.43e-04 GO:0034340 response to type I interferon
2.65 1.21e-03 GO:0051704 multi-organism process
5.58 1.98e-03 GO:0009615 response to virus
1.86 2.14e-03 GO:0048522 positive regulation of cellular process
5.06 2.20e-03 GO:0019221 cytokine-mediated signaling pathway
2.29 2.96e-03 GO:0002376 immune system process
7.49 3.58e-03 GO:0030330 DNA damage response, signal transduction by p53 class mediator
2.70 4.80e-03 GO:0006955 immune response
10.44 4.90e-03 GO:0032479 regulation of type I interferon production
1.77 5.82e-03 GO:0048518 positive regulation of biological process
2.60 6.22e-03 GO:0006508 proteolysis
4.56 6.89e-03 GO:0071345 cellular response to cytokine stimulus
7.34 1.48e-02 GO:0031575 mitotic cell cycle G1/S transition checkpoint
7.34 1.48e-02 GO:0071779 G1/S transition checkpoint
3.90 1.82e-02 GO:0001817 regulation of cytokine production
6.98 2.15e-02 GO:2000045 regulation of G1/S transition of mitotic cell cycle
6.02 2.17e-02 GO:0042770 signal transduction in response to DNA damage
8.21 2.49e-02 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
8.21 2.49e-02 GO:0072395 signal transduction involved in cell cycle checkpoint
8.21 2.49e-02 GO:0072401 signal transduction involved in DNA integrity checkpoint
8.21 2.49e-02 GO:0072404 signal transduction involved in G1/S transition checkpoint
8.21 2.49e-02 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
8.21 2.49e-02 GO:0072422 signal transduction involved in DNA damage checkpoint
8.21 2.49e-02 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
8.21 2.49e-02 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint
3.20 2.95e-02 GO:0051707 response to other organism
2.93 3.35e-02 GO:0009607 response to biotic stimulus
7.83 3.42e-02 GO:0071158 positive regulation of cell cycle arrest
20.44 3.80e-02 GO:0032728 positive regulation of interferon-beta production

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
7.95 4.38e-03 GO:0000502 proteasome complex
14.31 2.45e-02 GO:0005839 proteasome core complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.64 2.30e-03 GO:0005126 cytokine receptor binding
22.01 4.79e-03 GO:0001530 lipopolysaccharide binding
3.96 2.28e-02 GO:0005125 cytokine activity
2.09 3.61e-02 GO:0005102 receptor binding
13.63 3.68e-02 GO:0004298 threonine-type endopeptidase activity
13.63 3.68e-02 GO:0070003 threonine-type peptidase activity
2.52 4.31e-02 GO:0008233 peptidase activity