Motif ID: LEF1_TCF7_TCF7L1,2.p2

Z-value: 1.683


Transcription factors associated with LEF1_TCF7_TCF7L1,2.p2:

Gene SymbolEntrez IDGene Name
LEF1 51176 lymphoid enhancer-binding factor 1
TCF7 6932 transcription factor 7 (T-cell specific, HMG-box)
TCF7L1 83439 transcription factor 7-like 1 (T-cell specific, HMG-box)
TCF7L2 6934 transcription factor 7-like 2 (T-cell specific, HMG-box)



Activity profile for motif LEF1_TCF7_TCF7L1,2.p2.

activity profile for motif LEF1_TCF7_TCF7L1,2.p2


Sorted Z-values histogram for motif LEF1_TCF7_TCF7L1,2.p2

Sorted Z-values for motif LEF1_TCF7_TCF7L1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LEF1_TCF7_TCF7L1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_11597530 8.354 NM_148903
GREB1
growth regulation by estrogen in breast cancer 1
chr17_-_76985538 4.482


chr13_+_75232797 4.395 NM_015842
LMO7
LIM domain 7
chr12_-_120781002 4.373 NM_002150
HPD
4-hydroxyphenylpyruvate dioxygenase
chr5_-_16791346 4.230 MYO10
myosin X
chr17_-_60986905 4.136 AXIN2
axin 2
chr2_+_233443237 3.676 NM_206895
C2orf82
chromosome 2 open reading frame 82
chr2_+_228386800 3.625 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr7_+_72883128 3.593 NM_001305
CLDN4
claudin 4
chr18_-_24011349 3.418 NM_001792
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr3_-_150422474 3.250 NM_000096
CP
ceruloplasmin (ferroxidase)
chr10_+_7785347 3.218 ITIH2
inter-alpha (globulin) inhibitor H2
chr6_-_138935359 3.154 NM_020464
NHSL1
NHS-like 1
chr6_-_128883125 3.067 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr18_-_24010944 3.062 CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr10_+_7785360 3.022 ITIH2
inter-alpha (globulin) inhibitor H2
chr15_-_63457378 2.865 NM_004884
IGDCC3
immunoglobulin superfamily, DCC subclass, member 3
chr9_+_115265827 2.843 NM_017790
RGS3
regulator of G-protein signaling 3
chr10_+_53744043 2.840 NM_012242
DKK1
dickkopf homolog 1 (Xenopus laevis)
chr1_+_16203317 2.808 NM_178840
C1orf64
chromosome 1 open reading frame 64
chr8_-_145613034 2.764 SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr10_+_7785331 2.757 ITIH2
inter-alpha (globulin) inhibitor H2
chr6_+_167624792 2.754 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr2_-_75641535 2.639 FAM176A
family with sequence similarity 176, member A
chr20_-_32363268 2.612 NM_001161766
AHCY
adenosylhomocysteinase
chr6_+_131190237 2.592 NM_001195597
LOC285733
hypothetical LOC285733
chr2_-_75641587 2.578 NM_001135032
FAM176A
family with sequence similarity 176, member A
chr20_+_34937928 2.560 NM_080628
C20orf118
chromosome 20 open reading frame 118
chr13_+_23042722 2.535 NM_148957
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr5_-_58370693 2.517 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chr14_-_64479198 2.463 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr8_+_121892719 2.423


chr11_+_101488380 2.338 NM_001195045
YAP1
Yes-associated protein 1
chr10_+_7785235 2.306 NM_002216
ITIH2
inter-alpha (globulin) inhibitor H2
chr2_+_219354948 2.303 CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr16_+_56259657 2.267 NM_170776
GPR97
G protein-coupled receptor 97
chr10_+_7785290 2.251 ITIH2
inter-alpha (globulin) inhibitor H2
chr17_-_36347197 2.231 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr20_-_42457717 2.149


chr2_+_11600238 2.141 GREB1
growth regulation by estrogen in breast cancer 1
chr15_+_38082041 2.136 EIF2AK4
eukaryotic translation initiation factor 2 alpha kinase 4
chr8_-_121893196 2.121


chr12_+_1608672 2.117 NM_032642
WNT5B
wingless-type MMTV integration site family, member 5B
chr3_-_150858274 2.087 NM_001168280
NM_015472
WWTR1

WW domain containing transcription regulator 1

chr8_-_16903911 2.062 NM_019851
FGF20
fibroblast growth factor 20
chr8_-_121892877 2.061 SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr9_-_14858974 2.030 FREM1
FRAS1 related extracellular matrix 1
chr1_+_15957832 2.011 NM_017556
FBLIM1
filamin binding LIM protein 1
chr9_-_126309510 2.006 NM_004959
NR5A1
nuclear receptor subfamily 5, group A, member 1
chr2_-_241484245 1.989 NM_001085437
C2orf54
chromosome 2 open reading frame 54
chr17_+_69939806 1.969 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr7_+_29200636 1.958 NM_004067
CHN2
chimerin (chimaerin) 2
chr2_+_11600287 1.957 NM_033090
GREB1
growth regulation by estrogen in breast cancer 1
chr19_+_59061422 1.920 NM_001020820
MYADM
myeloid-associated differentiation marker
chrX_-_105169370 1.853 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr10_-_101831579 1.850 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr20_+_42399039 1.847 NM_178491
R3HDML
R3H domain containing-like
chr2_-_74606819 1.838 NM_133637
DQX1
DEAQ box RNA-dependent ATPase 1
chr10_+_135010833 1.773 NM_001145201
NM_145202
PRAP1

proline-rich acidic protein 1

chr11_+_46697345 1.769 F2
coagulation factor II (thrombin)
chr1_+_48460943 1.765 NM_001011547
NM_001135181
SLC5A9

solute carrier family 5 (sodium/glucose cotransporter), member 9

chr11_+_22646229 1.760 NM_177553
GAS2
growth arrest-specific 2
chr11_+_46697312 1.751 NM_000506
F2
coagulation factor II (thrombin)
chr17_-_43390108 1.748 NM_024320
PRR15L
proline rich 15-like
chr14_-_22521544 1.731 NM_032876
JUB
jub, ajuba homolog (Xenopus laevis)
chr17_-_36346240 1.714 KRT23
keratin 23 (histone deacetylase inducible)
chr2_+_54537842 1.685 SPTBN1
spectrin, beta, non-erythrocytic 1
chr20_+_31334601 1.655 NM_033197
C20orf114
chromosome 20 open reading frame 114
chr17_+_7900926 1.643


chr11_+_46697335 1.639 F2
coagulation factor II (thrombin)
chr1_-_16217871 1.631 NM_014424
HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr16_-_71639670 1.612 NM_006885
ZFHX3
zinc finger homeobox 3
chr19_-_18578467 1.612 CRLF1
cytokine receptor-like factor 1
chr17_-_44226595 1.593 NM_173623
TTLL6
tubulin tyrosine ligase-like family, member 6
chr11_+_62813947 1.582 NM_001039752
SLC22A10
solute carrier family 22, member 10
chr22_+_18330049 1.524 NM_007310
COMT
catechol-O-methyltransferase
chr9_+_111927601 1.519 NM_001136562
AKAP2
A kinase (PRKA) anchor protein 2
chr3_+_152970904 1.458 LOC201651
arylacetamide deacetylase (esterase) pseudogene
chr10_+_102722275 1.455 NM_017893
SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chrX_+_49718954 1.449 NM_000084
CLCN5
chloride channel 5
chr3_-_115960807 1.446 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr10_-_52315390 1.434 A1CF
APOBEC1 complementation factor
chr19_-_18578577 1.426 CRLF1
cytokine receptor-like factor 1
chr4_-_158111504 1.423 PDGFC
platelet derived growth factor C
chr1_+_57093030 1.422 NM_000562
C8A
complement component 8, alpha polypeptide
chr17_-_40348378 1.416 NM_001131019
NM_002055
GFAP

glial fibrillary acidic protein

chr1_-_11029737 1.406 NM_006610
NM_139208
MASP2

mannan-binding lectin serine peptidase 2

chr17_+_72795567 1.401 NM_001113492
SEPT9
septin 9
chr6_-_2785682 1.397 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr17_-_39437362 1.386 NM_004160
PYY
peptide YY
chr2_+_171280046 1.383 NM_001003845
SP5
Sp5 transcription factor
chr19_-_18578631 1.382 NM_004750
CRLF1
cytokine receptor-like factor 1
chr2_+_70981223 1.357 NM_012476
VAX2
ventral anterior homeobox 2
chr11_-_124311106 1.343 HEPACAM
hepatic and glial cell adhesion molecule
chr10_+_114144512 1.328 ACSL5
acyl-CoA synthetase long-chain family member 5
chr20_-_17459973 1.328 NM_001195
BFSP1
beaded filament structural protein 1, filensin
chr2_+_69093641 1.314 NM_018153
NM_032208
NM_053034
ANTXR1


anthrax toxin receptor 1


chr17_+_35425139 1.295 NM_000759
NM_001178147
NM_172219
NM_172220
CSF3



colony stimulating factor 3 (granulocyte)



chr13_+_109936080 1.295 COL4A2
collagen, type IV, alpha 2
chr17_-_23721468 1.266 VTN
vitronectin
chrX_+_46822751 1.262 RGN
regucalcin (senescence marker protein-30)
chr1_-_172153087 1.261 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr11_-_75599433 1.258 WNT11
wingless-type MMTV integration site family, member 11
chr16_+_70646008 1.258 NM_001126102
NM_005143
HP

haptoglobin

chr4_-_158111995 1.258 NM_016205
PDGFC
platelet derived growth factor C
chr1_-_36721501 1.249 NM_000760
NM_156039
NM_172313
CSF3R


colony stimulating factor 3 receptor (granulocyte)


chr14_-_34413831 1.246 BAZ1A
bromodomain adjacent to zinc finger domain, 1A
chr14_-_30746577 1.244


chr10_-_30064600 1.224 NM_003174
SVIL
supervillin
chr6_+_144649142 1.207 UTRN
utrophin
chr4_-_158111916 1.204 PDGFC
platelet derived growth factor C
chr13_-_22905822 1.179 NM_014363
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chrX_+_46822688 1.168 NM_004683
NM_152869
RGN

regucalcin (senescence marker protein-30)

chr7_-_27186400 1.163 NM_153715
HOXA10
homeobox A10
chr7_-_133794404 1.161 NM_001628
AKR1B1
aldo-keto reductase family 1, member B1 (aldose reductase)
chr7_+_128615948 1.160 NM_005631
SMO
smoothened homolog (Drosophila)
chr10_-_123346148 1.157 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr14_-_30746431 1.140 NM_015382
HECTD1
HECT domain containing 1
chr19_-_6671585 1.139 NM_000064
C3
complement component 3
chr15_+_60146467 1.134 NM_207322
C2CD4A
C2 calcium-dependent domain containing 4A
chr9_-_116190038 1.128 AKNA
AT-hook transcription factor
chr12_+_107797985 1.127 NM_001917
DAO
D-amino-acid oxidase
chr17_-_1359745 1.123 INPP5K
inositol polyphosphate-5-phosphatase K
chr8_-_42353719 1.115 NM_014420
DKK4
dickkopf homolog 4 (Xenopus laevis)
chrX_-_2857351 1.112 NM_001669
NM_009589
ARSD

arylsulfatase D

chr1_-_95165089 1.089 NM_001839
CNN3
calponin 3, acidic
chr1_-_172153024 1.088 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr9_-_35640852 1.087 NM_014450
SIT1
signaling threshold regulating transmembrane adaptor 1
chr2_+_171280182 1.083


chr15_+_78483624 1.075 NM_014862
ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr10_+_73393998 1.070 NM_004273
CHST3
carbohydrate (chondroitin 6) sulfotransferase 3
chr4_-_7991992 1.051 NM_001134647
NM_198595
AFAP1

actin filament associated protein 1

chrX_-_2857315 1.039 ARSD
arylsulfatase D
chr13_+_75108450 1.039 LMO7
LIM domain 7
chr8_+_103889733 1.038 FLJ45248
FLJ45248 protein
chr1_+_2026014 1.035 NM_001033582
PRKCZ
protein kinase C, zeta
chr10_-_52315436 1.032 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr12_-_15833383 1.029 EPS8
epidermal growth factor receptor pathway substrate 8
chr10_-_116434364 1.026 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr10_-_73518284 1.020 SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr1_-_1346465 1.019 NM_001145210
LOC441869
hypothetical protein LOC441869
chr1_-_110108048 1.019 NM_024526
NM_133181
NM_139053
EPS8L3


EPS8-like 3


chr3_-_115826481 1.016 NM_001164346
ZBTB20
zinc finger and BTB domain containing 20
chr19_-_17236522 1.005 NM_031941
USHBP1
Usher syndrome 1C binding protein 1
chr10_+_104619199 1.005 NM_020682
AS3MT
arsenic (+3 oxidation state) methyltransferase
chr17_+_19377732 0.996 NM_018242
SLC47A1
solute carrier family 47, member 1
chr14_-_93924663 0.996 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr2_+_233961538 0.989 NM_003648
DGKD
diacylglycerol kinase, delta 130kDa
chr20_+_39199263 0.986 PLCG1
phospholipase C, gamma 1
chr8_+_17478214 0.974 NM_006207
PDGFRL
platelet-derived growth factor receptor-like
chr7_+_142692165 0.973 NM_153345
TMEM139
transmembrane protein 139
chr14_+_22915772 0.971 NM_001037288
NM_138460
CMTM5

CKLF-like MARVEL transmembrane domain containing 5

chr1_-_108032645 0.966 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr10_+_24795446 0.947 KIAA1217
KIAA1217
chr11_+_62893836 0.940 NM_080866
SLC22A9
solute carrier family 22 (organic anion transporter), member 9
chr15_-_87565813 0.938 NM_000326
RLBP1
retinaldehyde binding protein 1
chr19_-_50506883 0.936 CKM
creatine kinase, muscle
chr4_+_146622154 0.935 NM_005900
SMAD1
SMAD family member 1
chr2_+_70981233 0.929 VAX2
ventral anterior homeobox 2
chr6_-_11340886 0.925 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr11_+_74548472 0.924 NM_001145211
SLCO2B1
solute carrier organic anion transporter family, member 2B1
chr13_+_95541093 0.910 NM_153456
HS6ST3
heparan sulfate 6-O-sulfotransferase 3
chr11_+_69165065 0.904 CCND1
cyclin D1
chr3_+_9919511 0.904 NM_001193380
NM_153480
IL17RE

interleukin 17 receptor E

chr6_-_11340869 0.903 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr3_+_187813405 0.902 AHSG
alpha-2-HS-glycoprotein
chr6_+_35812836 0.888 NM_145028
C6orf81
chromosome 6 open reading frame 81
chr3_-_121883647 0.883 HGD
homogentisate 1,2-dioxygenase
chr10_-_73518772 0.882 NM_001134434
NM_014767
SPOCK2

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2

chr6_-_11340887 0.879 NM_006403
NM_182966
NEDD9

neural precursor cell expressed, developmentally down-regulated 9

chr2_+_218992053 0.878 NM_007127
VIL1
villin 1
chr14_-_20642629 0.876 NM_001102454
ZNF219
zinc finger protein 219
chr17_-_53849888 0.874 RNF43
ring finger protein 43
chr8_+_18072250 0.863 NM_001160179
NAT1
N-acetyltransferase 1 (arylamine N-acetyltransferase)
chr11_+_69165018 0.861 NM_053056
CCND1
cyclin D1
chr11_+_69165119 0.860 CCND1
cyclin D1
chr17_-_60988226 0.855 AXIN2
axin 2
chr17_+_4621924 0.848 NM_003963
TM4SF5
transmembrane 4 L six family member 5
chr4_+_17125885 0.847 NM_001079827
CLRN2
clarin 2
chr20_-_42249146 0.844 JPH2
junctophilin 2
chr7_+_94953148 0.843 NM_016116
NM_145872
ASB4

ankyrin repeat and SOCS box containing 4

chr17_+_7474177 0.832 NM_001040
NM_001146279
NM_001146280
NM_001146281
SHBG



sex hormone-binding globulin



chr2_+_135312655 0.829 NM_138326
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr6_+_64339869 0.826 NM_003463
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr7_-_98643024 0.818 NM_001145715
KPNA7
karyopherin alpha 7 (importin alpha 8)
chr12_+_56406296 0.818 LOC100130776
hypothetical LOC100130776
chr1_-_229071957 0.816 NM_001136494
C1orf198
chromosome 1 open reading frame 198
chr12_+_19173669 0.814 NM_001143821
NM_001190860
NM_019012
PLEKHA5


pleckstrin homology domain containing, family A member 5


chr10_+_24795465 0.802 KIAA1217
KIAA1217
chr16_-_18720192 0.801 NM_015161
ARL6IP1
ADP-ribosylation factor-like 6 interacting protein 1
chr12_+_15366712 0.800 NM_002848
NM_030667
PTPRO

protein tyrosine phosphatase, receptor type, O

chr2_-_98714020 0.799 NM_012214
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr1_-_75854281 0.796 SLC44A5
solute carrier family 44, member 5
chr14_-_34414277 0.795 BAZ1A
bromodomain adjacent to zinc finger domain, 1A
chr4_-_40911212 0.795 NM_001166050
NM_004307
NM_173075
APBB2


amyloid beta (A4) precursor protein-binding, family B, member 2


chr14_+_38720085 0.793 PNN
pinin, desmosome associated protein
chrX_+_54852217 0.792 NM_201222
MAGED2
melanoma antigen family D, 2
chr11_+_69165159 0.791 CCND1
cyclin D1
chrX_+_152413646 0.791 BGN
biglycan
chr2_-_86418143 0.787 NM_001164731
NM_001164732
NM_022912
REEP1


receptor accessory protein 1



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.24 9.81e-05 GO:0032501 multicellular organismal process
1.27 7.02e-03 GO:0007275 multicellular organismal development
1.27 3.86e-02 GO:0048856 anatomical structure development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.52 2.48e-03 GO:0044421 extracellular region part
1.36 2.64e-02 GO:0005856 cytoskeleton

Nothing significant found in function category.