Motif ID: NKX3-1.p2

Z-value: 1.504


Transcription factors associated with NKX3-1.p2:

Gene SymbolEntrez IDGene Name
NKX3-1 4824 NK3 homeobox 1



Activity profile for motif NKX3-1.p2.

activity profile for motif NKX3-1.p2


Sorted Z-values histogram for motif NKX3-1.p2

Sorted Z-values for motif NKX3-1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX3-1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_132000134 4.150 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr17_-_53847937 3.717 RNF43
ring finger protein 43
chr14_+_38772870 1.562 NM_054024
MIA2
melanoma inhibitory activity 2
chr3_-_198784590 1.529 NM_203315
BDH1
3-hydroxybutyrate dehydrogenase, type 1
chr6_+_30238961 1.452 NM_033229
TRIM15
tripartite motif containing 15
chr10_-_11614279 1.348 NM_001080491
USP6NL
USP6 N-terminal like
chr12_+_91620749 1.278 NM_001037671
NM_001178097
C12orf74

chromosome 12 open reading frame 74

chr15_+_57691382 1.272 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr17_-_18890963 1.245 NM_006613
GRAP
GRB2-related adaptor protein
chr4_+_166350620 1.223 NM_001161521
NM_001161522
KLHL2

kelch-like 2, Mayven (Drosophila)

chr10_-_74384485 1.222 NM_032562
PLA2G12B
phospholipase A2, group XIIB
chr17_-_61655915 1.206 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr6_+_126282078 1.178 NCOA7
nuclear receptor coactivator 7
chr4_-_186969041 1.156 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr4_+_74520796 1.141 NM_001134
AFP
alpha-fetoprotein
chr4_+_74491272 1.119 ALB
albumin
chr6_+_64344307 1.097 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr14_+_87541220 1.089 NM_003608
GPR65
G protein-coupled receptor 65
chr14_-_22516271 1.087 NM_198086
JUB
jub, ajuba homolog (Xenopus laevis)
chr12_+_130004404 1.087 NM_198827
GPR133
G protein-coupled receptor 133
chr6_+_32003180 1.074 NM_000063
NM_001145903
C2

complement component 2

chr6_-_138862271 1.056 NM_001144060
NHSL1
NHS-like 1
chr14_+_66901237 1.052 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chrX_+_105823723 1.035 NM_024539
RNF128
ring finger protein 128
chr6_-_138862273 0.996


chr1_+_205329206 0.977 NM_000716
NM_001017364
NM_001017367
C4BPB


complement component 4 binding protein, beta


chr20_-_52120710 0.976 NM_003657
BCAS1
breast carcinoma amplified sequence 1
chr20_+_12937616 0.956 NM_018327
SPTLC3
serine palmitoyltransferase, long chain base subunit 3
chr4_+_89115862 0.945 SPP1
secreted phosphoprotein 1
chr2_-_165259334 0.936 COBLL1
COBL-like 1
chr4_+_89115892 0.932 SPP1
secreted phosphoprotein 1
chr4_+_89115923 0.906 SPP1
secreted phosphoprotein 1
chr4_+_89115825 0.894 NM_000582
NM_001040058
NM_001040060
SPP1


secreted phosphoprotein 1


chr1_+_190394214 0.888 NM_130782
RGS18
regulator of G-protein signaling 18
chrX_-_13744933 0.887 GPM6B
glycoprotein M6B
chr2_+_165858586 0.886 NM_021007
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr4_+_39084936 0.868 KLB
klotho beta
chr15_+_57691272 0.835 NM_004751
GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr6_+_53043729 0.833 NM_012347
FBXO9
F-box protein 9
chr7_+_115650240 0.832 NM_152829
TES
testis derived transcript (3 LIM domains)
chr1_+_57093030 0.831 NM_000562
C8A
complement component 8, alpha polypeptide
chr2_+_114390975 0.792 ACTR3
ARP3 actin-related protein 3 homolog (yeast)
chr12_-_101835510 0.785 NM_000277
PAH
phenylalanine hydroxylase
chr17_+_50698169 0.781 HLF
hepatic leukemia factor
chr1_-_229627412 0.779 NM_022051
EGLN1
egl nine homolog 1 (C. elegans)
chr3_+_50119261 0.768 RBM5
RNA binding motif protein 5
chr7_+_94377145 0.763 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory (inhibitor) subunit 9A


chr2_+_234624084 0.746 NM_006944
SPP2
secreted phosphoprotein 2, 24kDa
chr4_+_74488947 0.743 ALB
albumin
chrX_+_57329834 0.740 NM_174912
FAAH2
fatty acid amide hydrolase 2
chr4_+_74493918 0.740 ALB
albumin
chr9_+_4829763 0.734 RCL1
RNA terminal phosphate cyclase-like 1
chr6_+_32003380 0.731 C2
complement component 2
chr20_-_51633042 0.728 NM_006526
ZNF217
zinc finger protein 217
chr4_-_84254932 0.708 NM_001130715
NM_016619
PLAC8

placenta-specific 8

chr2_-_32344192 0.692 NM_021209
NLRC4
NLR family, CARD domain containing 4
chr2_+_61225710 0.687 NM_001143960
C2orf74
chromosome 2 open reading frame 74
chr2_-_233349469 0.682 NM_001172416
NM_001172417
NM_002242
KCNJ13


potassium inwardly-rectifying channel, subfamily J, member 13


chr20_+_30160952 0.682 NM_014742
TM9SF4
transmembrane 9 superfamily protein member 4
chr2_-_21106291 0.675 APOB
apolipoprotein B (including Ag(x) antigen)
chr3_+_113200696 0.662 NM_001008273
TAGLN3
transgelin 3
chr14_+_38804226 0.645 NM_203354
CTAGE5
CTAGE family, member 5
chr14_+_31868229 0.636 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr14_+_94148466 0.635 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr18_-_50776276 0.635 NM_001143829
CCDC68
coiled-coil domain containing 68
chr3_-_42892195 0.634 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr20_-_34707971 0.627 NM_032214
NM_175077
SLA2

Src-like-adaptor 2

chr20_-_43163021 0.621 NM_002251
KCNS1
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1
chr2_+_37282516 0.621 LOC100505876
hypothetical LOC100505876
chr8_-_17797127 0.609 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr16_+_82540172 0.603 NM_013370
NM_182980
OSGIN1

oxidative stress induced growth inhibitor 1

chr12_+_40117751 0.601 NM_013377
PDZRN4
PDZ domain containing ring finger 4
chr4_+_74488835 0.594 NM_000477
ALB
albumin
chrX_-_130792297 0.594 LOC286467
hypothetical LOC286467
chr17_+_58440629 0.586 NM_025185
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr10_-_98021144 0.582 NM_001114094
NM_013314
BLNK

B-cell linker

chr2_-_39310176 0.579 NM_001009565
CDKL4
cyclin-dependent kinase-like 4
chr6_+_31538934 0.570 NM_006674
HCP5
HLA complex P5
chr14_-_105681377 0.568 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr4_+_17125885 0.563 NM_001079827
CLRN2
clarin 2
chr2_+_183290912 0.558 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr9_+_109131814 0.554 RAD23B
RAD23 homolog B (S. cerevisiae)
chr2_+_135312655 0.554 NM_138326
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr6_-_48186868 0.552 C6orf138
chromosome 6 open reading frame 138
chr10_-_73953699 0.540 NM_001195519
CBARA1
calcium binding atopy-related autoantigen 1
chr3_-_195670256 0.535 NM_024524
ATP13A3
ATPase type 13A3
chr1_-_202449659 0.535 NM_198447
GOLT1A
golgi transport 1A
chr3_-_195553297 0.533 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr6_+_36752244 0.533 NM_078467
CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr16_+_80626331 0.532 NM_002153
HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr7_+_45899080 0.522 IGFBP1
insulin-like growth factor binding protein 1
chr1_+_74473672 0.521 NM_015978
TNNI3K
TNNI3 interacting kinase
chr5_+_43645018 0.520 NNT
nicotinamide nucleotide transhydrogenase
chr19_-_56549853 0.507 NM_001014763
ETFB
electron-transfer-flavoprotein, beta polypeptide
chr2_+_228064531 0.497 AGFG1
ArfGAP with FG repeats 1
chr14_-_101617680 0.493 HSP90AA1
heat shock protein 90kDa alpha (cytosolic), class A member 1
chr3_-_121883647 0.491 HGD
homogentisate 1,2-dioxygenase
chr16_+_80626459 0.486 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr2_+_201806410 0.485 NM_001080124
NM_001228
NM_033355
NM_033358
CASP8



caspase 8, apoptosis-related cysteine peptidase



chr4_-_10295412 0.485 NM_052964
CLNK
cytokine-dependent hematopoietic cell linker
chrX_-_2892288 0.481 NM_000047
ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr3_-_25658829 0.475 TOP2B
topoisomerase (DNA) II beta 180kDa
chr7_+_94953148 0.474 NM_016116
NM_145872
ASB4

ankyrin repeat and SOCS box containing 4

chr5_-_158690047 0.474 NM_002187
IL12B
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
chr8_-_59575249 0.473 NM_000780
CYP7A1
cytochrome P450, family 7, subfamily A, polypeptide 1
chr3_+_173043832 0.472 NM_001164436
TMEM212
transmembrane protein 212
chr3_+_129124591 0.460 NM_207335
KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr20_+_56919233 0.459 GNAS
GNAS complex locus
chr10_-_69267774 0.451 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr20_+_30161173 0.450 TM9SF4
transmembrane 9 superfamily protein member 4
chr1_+_66230977 0.448 NM_001037340
PDE4B
phosphodiesterase 4B, cAMP-specific
chr6_+_88021644 0.447 ZNF292
zinc finger protein 292
chr2_+_64534774 0.441 NM_014181
HSPC159
galectin-related protein
chr1_+_220977180 0.441 NM_207468
FAM177B
family with sequence similarity 177, member B
chr16_+_11346812 0.440 C16orf75
chromosome 16 open reading frame 75
chr3_+_171183203 0.439 SEC62
SEC62 homolog (S. cerevisiae)
chr18_+_27210737 0.439 NM_001134453
NM_177986
DSG4

desmoglein 4

chr4_-_84254873 0.439 PLAC8
placenta-specific 8
chr17_+_7682355 0.435


chr4_-_84254912 0.434 PLAC8
placenta-specific 8
chr5_-_179040580 0.434 NM_001164444
CBY3
chibby homolog 3 (Drosophila)
chrX_-_131989963 0.431 NM_031907
USP26
ubiquitin specific peptidase 26
chr9_+_21399132 0.429 NM_002170
IFNA8
interferon, alpha 8
chr6_+_167445284 0.422 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr13_+_51496679 0.420 NM_021645
ALG11
UTP14C
asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast)
UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)
chr16_+_80626402 0.420 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr1_+_165565006 0.419 POU2F1
POU class 2 homeobox 1
chr17_+_3324096 0.418 NM_001128085
ASPA
aspartoacylase
chr6_-_33016561 0.417 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr2_+_42649105 0.415 NM_020744
MTA3
metastasis associated 1 family, member 3
chr1_-_246869181 0.409 NM_001001827
OR2T35
olfactory receptor, family 2, subfamily T, member 35
chr11_-_30558495 0.409 NM_001584
MPPED2
metallophosphoesterase domain containing 2
chr7_+_141457977 0.403 LOC93432
maltase-glucoamylase-like pseudogene
chr4_+_88748704 0.403 NM_014208
DSPP
dentin sialophosphoprotein
chr12_+_100394787 0.403 NM_152323
SPIC
Spi-C transcription factor (Spi-1/PU.1 related)
chr14_-_22515725 0.399 JUB
jub, ajuba homolog (Xenopus laevis)
chr17_-_64752550 0.398 NM_080282
ABCA10
ATP-binding cassette, sub-family A (ABC1), member 10
chr14_-_24148658 0.393 NM_033423
GZMH
granzyme H (cathepsin G-like 2, protein h-CCPX)
chrX_+_99726445 0.392 NM_022144
TNMD
tenomodulin
chr6_+_153113624 0.387 NM_003381
NM_194435
VIP

vasoactive intestinal peptide

chr15_+_92700167 0.386 NM_001159644
MCTP2
multiple C2 domains, transmembrane 2
chr3_+_85858321 0.386 NM_153184
CADM2
cell adhesion molecule 2
chr6_+_46869052 0.385 NM_005588
MEP1A
meprin A, alpha (PABA peptide hydrolase)
chr12_+_25096472 0.381 NM_006152
LRMP
lymphoid-restricted membrane protein
chr20_+_43691797 0.380 NM_080753
WFDC10A
WAP four-disulfide core domain 10A
chr4_+_71418886 0.377 NM_212557
AMTN
amelotin
chr12_+_8167494 0.373 NM_016184
NM_194447
NM_194448
NM_194450
CLEC4A



C-type lectin domain family 4, member A



chrX_-_130251068 0.371 NM_001170961
NM_001170962
NM_001555
NM_205833
IGSF1



immunoglobulin superfamily, member 1



chr10_-_93992982 0.370 NM_001178137
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr14_-_74669864 0.368 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr2_-_144768529 0.368 NM_001006636
GTDC1
glycosyltransferase-like domain containing 1
chr1_+_158975662 0.365 NM_021181
SLAMF7
SLAM family member 7
chr2_+_227900471 0.365 NM_020194
MFF
mitochondrial fission factor
chr5_+_67622242 0.361 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr1_+_54132447 0.359 NM_000792
NM_001039715
NM_001039716
NM_213593
DIO1



deiodinase, iodothyronine, type I



chr3_-_156876798 0.357 NM_001130960
NM_001130961
PLCH1

phospholipase C, eta 1

chr1_-_39119845 0.354 NM_030772
GJA9-MYCBP
GJA9
GJA9-MYCBP read-through transcript
gap junction protein, alpha 9, 59kDa
chr1_-_158815850 0.353 CD84
CD84 molecule
chr1_-_205272619 0.351 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr16_+_80626456 0.351 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr6_+_16251260 0.349 MYLIP
myosin regulatory light chain interacting protein
chr10_+_124660206 0.348 NM_001029888
FAM24A
family with sequence similarity 24, member A
chr1_-_205012348 0.348 NM_000572
IL10
interleukin 10
chr14_+_22859236 0.346 NM_004643
PABPN1
poly(A) binding protein, nuclear 1
chr2_-_127817143 0.343 NM_006609
MAP3K2
mitogen-activated protein kinase kinase kinase 2
chr3_-_180452096 0.343 NM_014407
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr14_+_88130482 0.341 NM_207662
ZC3H14
zinc finger CCCH-type containing 14
chr10_+_102111361 0.341 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr11_-_83661878 0.340 NM_001142700
DLG2
discs, large homolog 2 (Drosophila)
chr6_-_99955987 0.338 SFRS18
splicing factor, arginine/serine-rich 18
chr13_+_23042722 0.331 NM_148957
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr4_+_75393053 0.330 NM_001013442
EPGN
epithelial mitogen homolog (mouse)
chr5_+_140583098 0.327 NM_018934
PCDHB14
protocadherin beta 14
chr19_+_56671649 0.327 NM_001080405
CEACAM18
carcinoembryonic antigen-related cell adhesion molecule 18
chr4_-_100575313 0.326 NM_001166504
NM_000673
ADH7

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

chr18_-_22699650 0.325 NM_001650
AQP4
aquaporin 4
chr1_+_246682699 0.323 NM_001004136
OR2T2
olfactory receptor, family 2, subfamily T, member 2
chr11_+_73036241 0.323 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr10_+_98054074 0.323 NM_001017520
NM_004088
DNTT

deoxynucleotidyltransferase, terminal

chr4_+_74498042 0.323 ALB
albumin
chrX_-_131375217 0.322 NM_001170701
NM_001170702
NM_001170703
MBNL3


muscleblind-like 3 (Drosophila)


chr18_-_22696532 0.320 NM_004028
AQP4
aquaporin 4
chr10_+_101078784 0.320 NM_020348
CNNM1
cyclin M1
chr6_+_49575629 0.318 NM_001010904
GLYATL3
glycine-N-acyltransferase-like 3
chr11_-_30910074 0.317 NM_020869
DCDC5
doublecortin domain containing 5
chr12_+_63510481 0.316


chr14_-_80475636 0.315 NM_152446
C14orf145
chromosome 14 open reading frame 145
chr8_-_37576515 0.315 LOC157860
hypothetical protein LOC157860
chr11_-_16953135 0.315 RPL36A
ribosomal protein L36a
chr17_-_16816113 0.310 NM_012452
TNFRSF13B
tumor necrosis factor receptor superfamily, member 13B
chr3_-_99236520 0.309 NM_001105580
GABRR3
gamma-aminobutyric acid (GABA) receptor, rho 3
chr5_+_102493155 0.307 NM_015216
PPIP5K2
diphosphoinositol pentakisphosphate kinase 2
chr20_+_17622319 0.307 NM_001159495
BANF2
barrier to autointegration factor 2
chr3_+_123279439 0.301 NM_006889
CD86
CD86 molecule
chr2_-_121964373 0.299 CLASP1
cytoplasmic linker associated protein 1
chr11_-_104332631 0.299 NM_033306
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr9_-_103237851 0.298 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr11_-_48330574 0.297 NM_001005513
OR4C45
olfactory receptor, family 4, subfamily C, member 45
chr16_-_21221872 0.297 NM_001014444
NM_001888
CRYM

crystallin, mu

chr3_-_42892636 0.296 NM_004391
CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.95 1.29e-10 GO:0007608 sensory perception of smell
2.77 5.01e-10 GO:0007606 sensory perception of chemical stimulus
1.98 1.27e-05 GO:0007600 sensory perception
1.25 1.40e-04 GO:0050896 response to stimulus
1.27 5.73e-04 GO:0032501 multicellular organismal process
9.20 1.53e-03 GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation
9.20 1.53e-03 GO:2000514 regulation of CD4-positive, alpha-beta T cell activation
1.79 4.56e-03 GO:0006952 defense response
1.50 7.37e-03 GO:0003008 system process
19.55 1.43e-02 GO:0032693 negative regulation of interleukin-10 production
1.55 1.92e-02 GO:0050877 neurological system process
9.77 2.62e-02 GO:0045622 regulation of T-helper cell differentiation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.33 2.32e-05 GO:0005886 plasma membrane
1.32 3.77e-05 GO:0071944 cell periphery
1.48 1.69e-04 GO:0005576 extracellular region
1.17 3.62e-02 GO:0044425 membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.99 4.68e-11 GO:0004984 olfactory receptor activity
2.04 2.56e-07 GO:0004930 G-protein coupled receptor activity
1.64 2.51e-06 GO:0004872 receptor activity
1.76 2.87e-06 GO:0004888 transmembrane receptor activity
1.53 1.61e-05 GO:0004871 signal transducer activity
1.53 1.61e-05 GO:0060089 molecular transducer activity
12.22 8.29e-03 GO:0005132 interferon-alpha/beta receptor binding
9.02 1.08e-02 GO:0004522 pancreatic ribonuclease activity
7.33 4.41e-02 GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters