Motif ID: STAT2,4,6.p2

Z-value: 1.474


Transcription factors associated with STAT2,4,6.p2:

Gene SymbolEntrez IDGene Name
STAT2 6773 signal transducer and activator of transcription 2, 113kDa
STAT4 6775 signal transducer and activator of transcription 4
STAT6 6778 signal transducer and activator of transcription 6, interleukin-4 induced



Activity profile for motif STAT2,4,6.p2.

activity profile for motif STAT2,4,6.p2


Sorted Z-values histogram for motif STAT2,4,6.p2

Sorted Z-values for motif STAT2,4,6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT2,4,6.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_49552638 1.801 NM_001083335
NM_013380
ZFP112

zinc finger protein 112 homolog (mouse)

chr12_+_54700955 1.799 NM_022465
IKZF4
IKAROS family zinc finger 4 (Eos)
chr2_-_178645718 1.631 NM_016953
PDE11A
phosphodiesterase 11A
chr3_-_71376919 1.560 FOXP1
forkhead box P1
chr3_-_188945921 1.539 BCL6
B-cell CLL/lymphoma 6
chr3_-_188946168 1.214 NM_001706
BCL6
B-cell CLL/lymphoma 6
chr12_+_51730101 1.086 NM_170754
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr5_+_38882017 1.053 OSMR
oncostatin M receptor
chr11_+_57121602 1.046 NM_000062
SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr5_-_121842680 1.033


chr11_+_57122153 1.011 NM_001032295
SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr5_+_145296313 1.009 NM_152550
SH3RF2
SH3 domain containing ring finger 2
chr20_-_48741481 0.996


chr14_+_94148466 0.982 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr5_+_140454382 0.934 NM_018936
PCDHB2
protocadherin beta 2
chr3_+_42176662 0.926 NM_014965
TRAK1
trafficking protein, kinesin binding 1
chr14_-_93988838 0.923 NM_001080451
SERPINA11
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11
chr1_+_17779528 0.913 NM_001011722
ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr1_+_203740391 0.913 CDK18
cyclin-dependent kinase 18
chr3_-_156876798 0.889 NM_001130960
NM_001130961
PLCH1

phospholipase C, eta 1

chr19_+_49248003 0.875 NM_013361
ZNF223
zinc finger protein 223
chr19_-_47438583 0.867 GSK3A
glycogen synthase kinase 3 alpha
chr16_-_28457728 0.858 NUPR1
nuclear protein, transcriptional regulator, 1
chr14_+_23175383 0.842 NM_005794
NM_182908
DHRS2

dehydrogenase/reductase (SDR family) member 2

chr6_+_30238961 0.831 NM_033229
TRIM15
tripartite motif containing 15
chr22_+_29848923 0.821 NM_001002837
INPP5J
inositol polyphosphate-5-phosphatase J
chr12_-_51200347 0.818 NM_000424
KRT5
keratin 5
chr2_+_17585287 0.809 NM_003385
VSNL1
visinin-like 1
chr3_-_185578621 0.800 NM_000460
NM_001177597
NM_001177598
THPO


thrombopoietin


chr14_+_23855291 0.788 LTB4R
leukotriene B4 receptor
chr19_-_47438548 0.770 GSK3A
glycogen synthase kinase 3 alpha
chr3_-_52839727 0.757 NM_001166449
NM_002218
ITIH4

inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)

chr19_+_40465249 0.756 NM_021175
HAMP
hepcidin antimicrobial peptide
chr19_-_47438563 0.756 NM_019884
GSK3A
glycogen synthase kinase 3 alpha
chr10_+_74540215 0.755 NM_015901
NUDT13
nudix (nucleoside diphosphate linked moiety X)-type motif 13
chr17_+_1593040 0.754 NM_001165920
SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr19_+_15079141 0.754 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr9_+_676640 0.751


chr3_+_186529376 0.749 MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr16_-_28457825 0.747 NM_001042483
NM_012385
NUPR1

nuclear protein, transcriptional regulator, 1

chr2_+_108360798 0.742 NM_006588
SULT1C4
sulfotransferase family, cytosolic, 1C, member 4
chr1_+_200246312 0.739 NM_001114309
NM_004433
ELF3

E74-like factor 3 (ets domain transcription factor, epithelial-specific )

chr2_-_166940710 0.727 NM_002977
SCN9A
sodium channel, voltage-gated, type IX, alpha subunit
chr12_+_51729239 0.721 TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr3_-_150422474 0.718 NM_000096
CP
ceruloplasmin (ferroxidase)
chr5_+_38881719 0.716 NM_003999
OSMR
oncostatin M receptor
chr19_-_47438518 0.716 GSK3A
glycogen synthase kinase 3 alpha
chr16_+_30903963 0.708 NM_001142777
NM_001142778
NM_025193
HSD3B7


hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7


chr5_+_73145098 0.707 RGNEF
190 kDa guanine nucleotide exchange factor
chr5_-_38881636 0.702


chr12_-_9159789 0.699 NM_000014
A2M
alpha-2-macroglobulin
chr16_+_29378694 0.699 NM_001017390
NM_177552
SULT1A4
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr17_+_1592893 0.689 SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr17_+_1592879 0.683 NM_000934
NM_001165921
SERPINF2

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2

chr16_-_55259405 0.683 NM_005950
MT1G
metallothionein 1G
chr2_-_43919392 0.682 NM_022436
ABCG5
ATP-binding cassette, sub-family G (WHITE), member 5
chr1_-_11029882 0.681 MASP2
mannan-binding lectin serine peptidase 2
chr3_+_187813553 0.680 AHSG
alpha-2-HS-glycoprotein
chr11_-_8788765 0.675 NM_213618
ST5
suppression of tumorigenicity 5
chr7_-_149669622 0.665 NM_002889
RARRES2
retinoic acid receptor responder (tazarotene induced) 2
chr3_+_52803823 0.654 NM_002217
ITIH3
inter-alpha (globulin) inhibitor H3
chr18_+_59295123 0.652 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr1_-_20682541 0.646


chr11_-_116168316 0.646 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr6_-_56615544 0.640 NM_001723
NM_015548
DST

dystonin

chr11_+_7463175 0.628 NM_198474
OLFML1
olfactomedin-like 1
chr2_+_43919606 0.627 NM_022437
ABCG8
ATP-binding cassette, sub-family G (WHITE), member 8
chr4_-_155731288 0.624 NM_000508
NM_021871
FGA

fibrinogen alpha chain

chr22_+_19458378 0.612 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr9_-_116305273 0.612 NM_001083885
DFNB31
deafness, autosomal recessive 31
chr9_-_114814286 0.610 NM_001101338
ZNF883
zinc finger protein 883
chr20_-_14266200 0.609 NM_013281
NM_198391
FLRT3

fibronectin leucine rich transmembrane protein 3

chr8_-_27525084 0.608 NM_001171138
CLU
clusterin
chr2_-_218516950 0.595 NM_022648
TNS1
tensin 1
chr1_-_11029737 0.593 NM_006610
NM_139208
MASP2

mannan-binding lectin serine peptidase 2

chr1_+_200246370 0.588 ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr14_-_22516271 0.587 NM_198086
JUB
jub, ajuba homolog (Xenopus laevis)
chr6_-_152744143 0.581 SYNE1
spectrin repeat containing, nuclear envelope 1
chr2_-_79240293 0.577 NM_138938
NM_002580
NM_138937
REG3A


regenerating islet-derived 3 alpha


chr14_-_93829347 0.576 NM_001100607
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr19_-_54258935 0.574 NM_006179
NTF4
neurotrophin 4
chr7_-_100077072 0.574 NM_003227
TFR2
transferrin receptor 2
chr3_+_187813538 0.569 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr12_+_7038240 0.569 NM_001734
NM_201442
C1S

complement component 1, s subcomponent

chr3_+_187813405 0.564 AHSG
alpha-2-HS-glycoprotein
chr6_+_32003380 0.564 C2
complement component 2
chr1_+_153366559 0.561 EFNA1
ephrin-A1
chr5_+_38881716 0.561 NM_001168355
OSMR
oncostatin M receptor
chr19_+_702108 0.557 NM_173481
C19orf21
chromosome 19 open reading frame 21
chr14_-_64479198 0.557 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr20_+_2743613 0.556 NM_080739
C20orf141
chromosome 20 open reading frame 141
chr16_+_88515917 0.548 NM_001197181
TUBB3
tubulin, beta 3
chr17_+_55269974 0.545


chr12_+_6363482 0.544 NM_002342
LTBR
lymphotoxin beta receptor (TNFR superfamily, member 3)
chr3_+_189353502 0.541 LPP
LIM domain containing preferred translocation partner in lipoma
chr5_+_176449156 0.537 NM_022963
FGFR4
fibroblast growth factor receptor 4
chr17_+_4621924 0.531 NM_003963
TM4SF5
transmembrane 4 L six family member 5
chr2_-_86186441 0.521 POLR1A
polymerase (RNA) I polypeptide A, 194kDa
chr1_-_143706300 0.520 NM_001002812
NM_014644
NM_001002810
NM_001198834
NM_001195261
PDE4DIP




phosphodiesterase 4D interacting protein




chrX_-_132947141 0.512 GPC3
glypican 3
chr8_-_130868315 0.511 NM_031415
GSDMC
gasdermin C
chr19_-_12028126 0.509 NM_001080404
ZNF878
zinc finger protein 878
chr6_-_150080912 0.509 LATS1
LATS, large tumor suppressor, homolog 1 (Drosophila)
chr9_-_116920232 0.508 NM_002160
TNC
tenascin C
chr7_-_5429702 0.508 NM_001080495
TNRC18
trinucleotide repeat containing 18
chr16_+_70646008 0.508 NM_001126102
NM_005143
HP

haptoglobin

chr10_+_86121526 0.506 FAM190B
family with sequence similarity 190, member B
chr15_-_38908197 0.506 NM_001130143
NM_017726
PPP1R14D

protein phosphatase 1, regulatory (inhibitor) subunit 14D

chr8_-_27524744 0.503 NM_203339
CLU
clusterin
chrX_-_132947290 0.500 NM_001164617
NM_001164618
NM_001164619
NM_004484
GPC3



glypican 3



chr2_+_165858586 0.500 NM_021007
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr19_+_40299058 0.499 FXYD3
FXYD domain containing ion transport regulator 3
chr11_-_11986704 0.499 NM_001018057
DKK3
dickkopf homolog 3 (Xenopus laevis)
chr1_-_228916486 0.498 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr1_-_228916470 0.497 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr2_-_75650355 0.494 NM_032181
FAM176A
family with sequence similarity 176, member A
chr1_-_225572419 0.493 NM_003607
NM_014826
CDC42BPA

CDC42 binding protein kinase alpha (DMPK-like)

chr2_-_160764819 0.489 NM_000888
ITGB6
integrin, beta 6
chr8_-_127639892 0.484 NM_174911
FAM84B
family with sequence similarity 84, member B
chr2_+_27573206 0.481 NM_001486
GCKR
glucokinase (hexokinase 4) regulator
chr10_-_52315390 0.480 A1CF
APOBEC1 complementation factor
chr9_-_34618010 0.476 NM_001017363
ARID3C
AT rich interactive domain 3C (BRIGHT-like)
chr2_-_200028977 0.460 SATB2
SATB homeobox 2
chr1_+_154178103 0.456 NM_181885
RXFP4
relaxin/insulin-like family peptide receptor 4
chr19_-_47438384 0.455 GSK3A
glycogen synthase kinase 3 alpha
chr12_+_50633430 0.455 NM_020327
ACVR1B
activin A receptor, type IB
chr19_+_40224457 0.453 HPN
hepsin
chr1_+_36462583 0.453 NM_005119
THRAP3
thyroid hormone receptor associated protein 3
chr1_-_199635240 0.450 NM_005558
LAD1
ladinin 1
chr12_-_9159742 0.448 A2M
alpha-2-macroglobulin
chrX_-_100549561 0.441 NM_000169
GLA
galactosidase, alpha
chr9_+_102830851 0.440 NM_207299
LPPR1
lipid phosphate phosphatase-related protein type 1
chr16_+_2025922 0.439 SLC9A3R2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr1_+_58899 0.438 NM_001005484
OR4F4
OR4F5
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 5
chr3_+_185537969 0.437 NM_144635
FAM131A
family with sequence similarity 131, member A
chr6_-_150080852 0.436 LATS1
LATS, large tumor suppressor, homolog 1 (Drosophila)
chr12_-_9159780 0.435 A2M
alpha-2-macroglobulin
chr20_-_49747397 0.434 ATP9A
ATPase, class II, type 9A
chr4_-_155753249 0.430 FGG
fibrinogen gamma chain
chr17_-_74487527 0.429 NM_005567
LGALS3BP
lectin, galactoside-binding, soluble, 3 binding protein
chrX_+_100549869 0.428 HNRNPH2
heterogeneous nuclear ribonucleoprotein H2 (H')
chr6_-_152744022 0.427 SYNE1
spectrin repeat containing, nuclear envelope 1
chr10_-_101831579 0.427 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr11_+_62893836 0.426 NM_080866
SLC22A9
solute carrier family 22 (organic anion transporter), member 9
chrX_+_100549861 0.422 HNRNPH2
heterogeneous nuclear ribonucleoprotein H2 (H')
chr19_+_40298571 0.422 NM_001136007
NM_001136008
NM_001136009
NM_001136010
NM_001136011
NM_001136012
NM_005971
NM_021910
FXYD3







FXYD domain containing ion transport regulator 3







chr1_-_228916559 0.421 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chrX_+_37093448 0.420 NM_000950
NM_001142395
NM_001173486
NM_001173489
NM_001173490
PRRG1




proline rich Gla (G-carboxyglutamic acid) 1




chrX_+_100549839 0.420 NM_001032393
NM_019597
HNRNPH2

heterogeneous nuclear ribonucleoprotein H2 (H')

chr4_-_100284395 0.420 NM_000670
ADH4
alcohol dehydrogenase 4 (class II), pi polypeptide
chr20_+_9963696 0.419 NM_022096
NM_198798
ANKRD5

ankyrin repeat domain 5

chr20_+_30409649 0.419 NM_001164603
NM_015338
ASXL1

additional sex combs like 1 (Drosophila)

chr4_-_155753207 0.418 FGG
fibrinogen gamma chain
chr4_-_155753272 0.416 FGG
fibrinogen gamma chain
chrX_-_48213545 0.416 NM_033518
SLC38A5
solute carrier family 38, member 5
chr1_+_242883057 0.415 PPPDE1
PPPDE peptidase domain containing 1
chr11_-_66431910 0.413 NM_022172
PC
pyruvate carboxylase
chr1_+_203740306 0.412 NM_002596
NM_212502
NM_212503
CDK18


cyclin-dependent kinase 18


chr12_-_55730125 0.411 NM_005379
MYO1A
myosin IA
chr1_+_95058488 0.411 NM_001114106
SLC44A3
solute carrier family 44, member 3
chr2_-_160765008 0.411 ITGB6
integrin, beta 6
chr6_+_32021899 0.409 CFB
complement factor B
chr7_+_134114912 0.409 CALD1
caldesmon 1
chr4_-_155753287 0.409 FGG
fibrinogen gamma chain
chr11_+_73034870 0.408 NM_001130033
NM_021200
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr4_+_128773529 0.408 NM_015693
INTU
inturned planar cell polarity effector homolog (Drosophila)
chr14_+_31868229 0.394 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr7_+_134114957 0.394 CALD1
caldesmon 1
chr1_-_228916958 0.394 NM_000029
AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr19_-_40693176 0.392 NM_001126059
DMKN
dermokine
chr12_-_53059234 0.391 ZNF385A
zinc finger protein 385A
chr17_-_7023283 0.391 ASGR1
asialoglycoprotein receptor 1
chr4_-_155753332 0.391 NM_000509
NM_021870
FGG

fibrinogen gamma chain

chr3_+_173043832 0.390 NM_001164436
TMEM212
transmembrane protein 212
chr15_-_40236061 0.389 NM_213600
PLA2G4F
phospholipase A2, group IVF
chr14_+_19881552 0.387 NM_001042618
NM_005484
PARP2

poly (ADP-ribose) polymerase 2

chr6_+_32229278 0.386 NM_138717
PPT2
palmitoyl-protein thioesterase 2
chr2_+_201756048 0.385 CASP10
caspase 10, apoptosis-related cysteine peptidase
chr2_-_180135559 0.382 NM_001113398
ZNF385B
zinc finger protein 385B
chr2_-_228290942 0.382 NM_025243
SLC19A3
solute carrier family 19, member 3
chr17_-_38979178 0.382 NM_001079675
ETV4
ets variant 4
chr17_-_7023378 0.378 NM_001197216
NM_001671
ASGR1

asialoglycoprotein receptor 1

chr2_+_14690260 0.377 NM_145175
FAM84A
family with sequence similarity 84, member A
chr7_+_138469029 0.370 NM_001144920
NM_001144923
NM_024926
TTC26


tetratricopeptide repeat domain 26


chr1_-_94147574 0.368 NM_002061
GCLM
glutamate-cysteine ligase, modifier subunit
chr20_+_31713750 0.368 NM_080825
C20orf144
chromosome 20 open reading frame 144
chr6_+_32021742 0.367 CFB
complement factor B
chr20_+_43470354 0.365 DBNDD2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr20_+_17622319 0.365 NM_001159495
BANF2
barrier to autointegration factor 2
chr16_+_52025874 0.364 RBL2
retinoblastoma-like 2 (p130)
chrX_-_48213508 0.363 SLC38A5
solute carrier family 38, member 5
chr20_+_51022352 0.363 NM_173485
TSHZ2
teashirt zinc finger homeobox 2
chr16_+_24696069 0.362 TNRC6A
trinucleotide repeat containing 6A
chr2_+_201755865 0.361 NM_001230
NM_032974
NM_032977
CASP10


caspase 10, apoptosis-related cysteine peptidase


chr21_-_46399900 0.361 NM_006657
NM_206965
FTCD

formiminotransferase cyclodeaminase

chr1_+_95058687 0.361 NM_152369
SLC44A3
solute carrier family 44, member 3
chr19_+_3536541 0.360 NM_133261
GIPC3
GIPC PDZ domain containing family, member 3
chr5_+_131437383 0.360 NM_000758
CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr1_-_51560469 0.359 NM_001080494
TTC39A
tetratricopeptide repeat domain 39A
chr1_-_36721010 0.358 CSF3R
colony stimulating factor 3 receptor (granulocyte)

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.81 1.46e-03 GO:0016323 basolateral plasma membrane
1.93 8.80e-03 GO:0005912 adherens junction
2.08 1.48e-02 GO:0030055 cell-substrate junction
2.12 1.62e-02 GO:0005925 focal adhesion
1.08 1.98e-02 GO:0005737 cytoplasm
2.02 4.50e-02 GO:0005924 cell-substrate adherens junction

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.10 2.07e-03 GO:0005515 protein binding
6.01 4.57e-02 GO:0003708 retinoic acid receptor activity