Motif ID: IKZF2.p2

Z-value: 1.331


Transcription factors associated with IKZF2.p2:

Gene SymbolEntrez IDGene Name
IKZF2 22807 IKAROS family zinc finger 2 (Helios)



Activity profile for motif IKZF2.p2.

activity profile for motif IKZF2.p2


Sorted Z-values histogram for motif IKZF2.p2

Sorted Z-values for motif IKZF2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of IKZF2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_16471817 2.630 NM_015464
SOSTDC1
sclerostin domain containing 1
chr9_+_74956494 2.371 NM_000700
ANXA1
annexin A1
chr18_+_27281729 2.217 NM_001944
DSG3
desmoglein 3
chr1_+_99884018 2.169 NM_017734
PALMD
palmdelphin
chr2_+_157822355 2.136 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chrX_+_28515479 2.084 NM_014271
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr6_+_106653429 2.037 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chrX_-_153698930 1.840 HMGN1P37
high-mobility group nucleosome binding domain 1 pseudogene 37
chr13_-_37070862 1.725 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chrX_-_102828238 1.721 NM_001142418
NM_001142423
NM_001142424
NM_001142425
NM_001142426
NM_001142429
NM_001142430
NM_012286
MORF4L2







mortality factor 4 like 2







chr14_+_85066265 1.709 FLRT2
fibronectin leucine rich transmembrane protein 2
chr1_-_109201228 1.689 NM_152763
AKNAD1
AKNA domain containing 1
chr1_+_161305558 1.650 NM_001113381
RGS4
regulator of G-protein signaling 4
chr2_-_162808123 1.606 NM_004460
FAP
fibroblast activation protein, alpha
chr5_+_96237399 1.583 NM_001130140
NM_022350
ERAP2

endoplasmic reticulum aminopeptidase 2

chr10_+_111755715 1.537 NM_019903
ADD3
adducin 3 (gamma)
chr17_+_36515166 1.525 NM_001146041
KRTAP4-9
keratin associated protein 4-9
chr17_-_64649608 1.523 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr7_-_22518200 1.508 EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr13_-_101852028 1.500 NM_175929
FGF14
fibroblast growth factor 14
chr7_-_83662152 1.469 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr13_+_48582389 1.466 NM_014923
FNDC3A
fibronectin type III domain containing 3A
chr3_+_69895310 1.457 NM_001184967
MITF
microphthalmia-associated transcription factor
chr6_+_27215039 1.444 NM_003495
HIST1H4I
histone cluster 1, H4i
chr4_-_153493133 1.441 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr21_-_31995972 1.411 SCAF4
SR-related CTD-associated factor 4
chr6_-_47117951 1.411 NM_025048
NM_153840
GPR110

G protein-coupled receptor 110

chr8_-_6407882 1.410 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chrX_+_73080887 1.404 NCRNA00183
non-protein coding RNA 183
chr8_-_13416554 1.382 NM_024767
NM_182643
DLC1

deleted in liver cancer 1

chr11_+_65026382 1.357


chr6_-_68655708 1.352


chr7_-_13992351 1.352 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr4_-_90197140 1.340 NM_014883
FAM13A
family with sequence similarity 13, member A
chr1_+_53253204 1.336 SCP2
sterol carrier protein 2
chr4_-_153523113 1.325 NM_001013415
FBXW7
F-box and WD repeat domain containing 7
chr1_+_201862845 1.324 ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chr11_-_95715976 1.302 NM_032427
MAML2
mastermind-like 2 (Drosophila)
chr17_+_29606408 1.285 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr12_-_48902692 1.262 NM_001113547
LIMA1
LIM domain and actin binding 1
chr21_+_38550739 1.261 NM_170736
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr1_+_53253161 1.252 NM_001007099
NM_001007100
NM_001007250
SCP2


sterol carrier protein 2


chr3_-_170346760 1.237 NM_001105077
NM_001163999
NM_005241
MECOM


MDS1 and EVI1 complex locus


chr2_-_134042500 1.230 NM_207363
NM_207481
NCKAP5

NCK-associated protein 5

chr1_+_169326641 1.230 NM_001002294
NM_006894
FMO3

flavin containing monooxygenase 3

chr17_-_64462976 1.204 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr4_+_130236731 1.202 NM_001099783
C4orf33
chromosome 4 open reading frame 33
chr2_+_66519949 1.184 MEIS1
Meis homeobox 1
chr18_+_54039818 1.178 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr1_+_194887630 1.158 NM_000186
NM_001014975
CFH

complement factor H

chr4_-_152366970 1.152 NM_001009555
NM_001128923
SH3D19

SH3 domain containing 19

chr14_+_62740878 1.149 NM_020663
RHOJ
ras homolog gene family, member J
chr17_-_51155073 1.134 NM_018286
TMEM100
transmembrane protein 100
chr11_-_5227611 1.134 NM_000559
HBG1
HBG2
hemoglobin, gamma A
hemoglobin, gamma G
chr7_-_112545847 1.133 LOC401397
hypothetical LOC401397
chr11_+_65027721 1.131


chr7_-_41709191 1.117 NM_002192
INHBA
inhibin, beta A
chr1_+_19807168 1.113


chr5_+_40877053 1.111 NM_032587
CARD6
caspase recruitment domain family, member 6
chr4_+_134289893 1.093 NM_020815
NM_032961
PCDH10

protocadherin 10

chr1_-_68470585 1.093 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr6_+_147568795 1.092 STXBP5
syntaxin binding protein 5 (tomosyn)
chr4_+_95595419 1.085 PDLIM5
PDZ and LIM domain 5
chr1_-_191422346 1.082 NM_003783
B3GALT2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr18_+_54013575 1.082 NM_001144970
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr3_+_186563529 1.061 NM_004721
MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr3_+_69998064 1.060 NM_198177
MITF
microphthalmia-associated transcription factor
chr6_-_42293577 1.052 MRPS10
mitochondrial ribosomal protein S10
chr1_+_169421011 1.050 NM_001460
FMO2
flavin containing monooxygenase 2 (non-functional)
chr4_+_170817787 1.047 CLCN3
chloride channel 3
chr5_+_140698537 1.037 NM_018915
NM_032009
PCDHGA2

protocadherin gamma subfamily A, 2

chr2_-_189752575 1.032 NM_000393
COL5A2
collagen, type V, alpha 2
chr6_-_42293564 1.029 MRPS10
mitochondrial ribosomal protein S10
chr1_-_171838802 1.027 NM_178527
SLC9A11
solute carrier family 9, member 11
chr1_+_84539876 1.026 NM_001134663
SAMD13
sterile alpha motif domain containing 13
chr4_-_159312973 0.994 FAM198B
family with sequence similarity 198, member B
chr4_-_89963177 0.988 NM_001015045
FAM13A
family with sequence similarity 13, member A
chr1_+_68070573 0.987


chrX_+_56772391 0.981 LOC550643
hypothetical LOC550643
chr3_+_25445071 0.976 RARB
retinoic acid receptor, beta
chr6_+_129245978 0.974 NM_000426
NM_001079823
LAMA2

laminin, alpha 2

chr12_+_45759634 0.964 FAM113B
family with sequence similarity 113, member B
chr5_-_58607673 0.959 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr4_+_159351092 0.957 TMEM144
transmembrane protein 144
chr3_-_64648370 0.954 NM_182920
ADAMTS9
ADAM metallopeptidase with thrombospondin type 1 motif, 9
chr10_-_45131061 0.950 NM_001004297
OR13A1
olfactory receptor, family 13, subfamily A, member 1
chr6_+_106640903 0.938 PRDM1
PR domain containing 1, with ZNF domain
chr12_-_52939584 0.936 NM_001127322
CBX5
chromobox homolog 5
chr8_+_39890484 0.929 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr4_-_158111504 0.929 PDGFC
platelet derived growth factor C
chr14_-_22693333 0.925 NM_182728
SLC7A8
solute carrier family 7 (amino acid transporter, L-type), member 8
chr6_-_50025115 0.924 NM_001166478
DEFB133
defensin, beta 133
chr6_-_42293575 0.923 MRPS10
mitochondrial ribosomal protein S10
chr6_+_121798443 0.920 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr8_-_17599438 0.920 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr7_+_91762227 0.919


chr1_+_160618143 0.918 NM_001085375
C1orf226
chromosome 1 open reading frame 226
chr20_-_44746529 0.917 NM_001011554
NM_001193340
SLC13A3

solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3

chr1_-_194844061 0.903 NM_198503
KCNT2
potassium channel, subfamily T, member 2
chr1_-_149047329 0.899 NM_000396
CTSK
cathepsin K
chr11_-_56846246 0.888 TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr7_+_120416103 0.886 C7orf58
chromosome 7 open reading frame 58
chr16_+_81218142 0.880 CDH13
cadherin 13, H-cadherin (heart)
chr12_-_90097384 0.876 NM_133503
DCN
decorin
chr18_+_30544193 0.874 NM_001198941
NM_032978
DTNA

dystrobrevin, alpha

chr1_+_22107137 0.872 RPL21
ribosomal protein L21
chr14_+_85066207 0.868 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chr16_+_81218074 0.862 NM_001257
CDH13
cadherin 13, H-cadherin (heart)
chr2_-_144994349 0.861 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr7_-_13996166 0.852 NM_001163147
NM_004956
ETV1

ets variant 1

chr18_+_3443771 0.851 NM_173211
TGIF1
TGFB-induced factor homeobox 1
chr3_-_170864111 0.850 NM_004991
MECOM
MDS1 and EVI1 complex locus
chr7_+_120415958 0.847 NM_024913
C7orf58
chromosome 7 open reading frame 58
chr22_-_41685827 0.843 NM_001184971
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr5_-_59100194 0.840 NM_001197218
PDE4D
phosphodiesterase 4D, cAMP-specific
chr7_-_75794919 0.838 YWHAG
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
chr4_+_15080586 0.836 NM_001080522
NM_001164720
NM_020785
CC2D2A


coiled-coil and C2 domain containing 2A


chr1_-_151804929 0.830 NM_005978
S100A2
S100 calcium binding protein A2
chr2_+_158559936 0.822 NM_001135098
UPP2
uridine phosphorylase 2
chr1_+_161305188 0.818 NM_005613
RGS4
regulator of G-protein signaling 4
chr17_+_36636404 0.817 NM_031961
KRTAP9-2
keratin associated protein 9-2
chr11_+_65023556 0.815


chr7_+_102340579 0.815 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr3_-_12561962 0.814 NM_001195279
LOC100129480
hypothetical protein LOC100129480
chr11_+_113671744 0.812 NM_006169
NNMT
nicotinamide N-methyltransferase
chr19_-_48382398 0.811 NM_001130014
NM_002781
PSG5

pregnancy specific beta-1-glycoprotein 5

chrX_-_73430064 0.809 MIR374AHG
mir-374a-545 cluster host gene (non-protein coding)
chr4_-_24590867 0.805 NM_173463
CCDC149
coiled-coil domain containing 149
chr17_+_36493927 0.802 NM_033061
KRTAP4-7
keratin associated protein 4-7
chr20_-_17487480 0.800 NM_001161705
BFSP1
beaded filament structural protein 1, filensin
chr18_+_54039779 0.799 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr19_-_36531958 0.792 NM_020856
TSHZ3
teashirt zinc finger homeobox 3
chr5_+_54491702 0.792 NM_001008397
GPX8
glutathione peroxidase 8 (putative)
chr1_+_169484256 0.791 NM_002021
FMO1
flavin containing monooxygenase 1
chr6_+_106640881 0.790 NM_001198
PRDM1
PR domain containing 1, with ZNF domain
chr18_+_54039730 0.786 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr18_-_20105900 0.783 OSBPL1A
oxysterol binding protein-like 1A
chrX_-_33139349 0.783 NM_004006
DMD
dystrophin
chr16_-_63713382 0.782 NM_001797
CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr13_-_33148899 0.781 STARD13
StAR-related lipid transfer (START) domain containing 13
chr14_+_38804226 0.780 NM_203354
CTAGE5
CTAGE family, member 5
chr1_+_181422016 0.779 LAMC2
laminin, gamma 2
chr7_-_92686773 0.776 NM_198151
HEPACAM2
HEPACAM family member 2
chr2_+_202379442 0.774 NM_139158
CDK15
cyclin-dependent kinase 15
chr6_+_42896771 0.772 NM_015349
KIAA0240
KIAA0240
chr1_-_21478571 0.772 NM_001113347
ECE1
endothelin converting enzyme 1
chr9_-_90983195 0.762 SHC3
SHC (Src homology 2 domain containing) transforming protein 3
chr4_+_154083584 0.758 NM_033393
FHDC1
FH2 domain containing 1
chr8_-_102029997 0.758 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr1_+_239762179 0.753 NM_003679
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr9_+_129893948 0.748 NM_001006642
SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr19_-_48401532 0.744 NM_002780
NM_213633
PSG4

pregnancy specific beta-1-glycoprotein 4

chr21_-_27261276 0.742 NM_007038
ADAMTS5
ADAM metallopeptidase with thrombospondin type 1 motif, 5
chr21_-_35174742 0.740 RUNX1
runt-related transcription factor 1
chr15_+_30721161 0.738 NM_001144757
NM_003020
SCG5

secretogranin V (7B2 protein)

chr7_-_136678815 0.732 PTN
pleiotrophin
chr3_+_25444837 0.730 NM_000965
RARB
retinoic acid receptor, beta
chr2_+_102320148 0.725 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr15_+_60838053 0.724 TLN2
talin 2
chr11_-_85115105 0.724 NM_206927
NM_206928
SYTL2

synaptotagmin-like 2

chr10_+_91077581 0.724 NM_001549
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chrX_+_100692071 0.721 NM_016608
ARMCX1
armadillo repeat containing, X-linked 1
chr2_+_201755865 0.720 NM_001230
NM_032974
NM_032977
CASP10


caspase 10, apoptosis-related cysteine peptidase


chr4_+_154345039 0.720 NM_015271
TRIM2
tripartite motif containing 2
chr4_-_120462705 0.716 NM_000134
FABP2
fatty acid binding protein 2, intestinal
chr1_-_51660328 0.711 NM_001159969
EPS15
epidermal growth factor receptor pathway substrate 15
chr3_-_143230124 0.710 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr8_-_116750427 0.704 TRPS1
trichorhinophalangeal syndrome I
chr4_-_159313167 0.699 NM_016613
FAM198B
family with sequence similarity 198, member B
chr1_+_61642287 0.697 NFIA
nuclear factor I/A
chr10_+_35524835 0.697 NM_182721
NM_182722
NM_182723
NM_182724
NM_182725
CREM




cAMP responsive element modulator




chr1_+_181421984 0.692 LAMC2
laminin, gamma 2
chr7_+_129634935 0.689 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr10_+_102111361 0.689 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr15_-_68781662 0.682 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr1_+_199884072 0.680 NM_020443
NAV1
neuron navigator 1
chrX_+_119622570 0.679 NM_001137554
MCTS1
malignant T cell amplified sequence 1
chr9_-_36266930 0.678 NM_001128227
NM_001190388
GNE

glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase

chr8_+_124264054 0.677 FAM83A
family with sequence similarity 83, member A
chr8_+_107529327 0.676 NM_001198532
OXR1
oxidation resistance 1
chr3_+_9451506 0.676


chr1_+_160868932 0.669 DDR2
discoidin domain receptor tyrosine kinase 2
chr1_-_79244948 0.664 NM_022159
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chr5_+_96237923 0.664 ERAP2
endoplasmic reticulum aminopeptidase 2
chr8_+_32698892 0.662 NM_001159996
NRG1
neuregulin 1
chr6_-_111995213 0.662 NM_001164283
TRAF3IP2
TRAF3 interacting protein 2
chrX_-_102829595 0.661 MORF4L2
mortality factor 4 like 2
chr12_-_84754112 0.659 RASSF9
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
chr7_-_112545840 0.659 LOC401397
hypothetical LOC401397
chr6_-_11887265 0.657 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr7_+_156677777 0.655


chrX_-_24575146 0.652 PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr2_+_33514896 0.651 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr12_-_51629874 0.649 KRT8
keratin 8
chr5_+_140690387 0.647 NM_018912
NM_031993
PCDHGA1

protocadherin gamma subfamily A, 1

chr20_-_33489383 0.647 NM_000557
GDF5
growth differentiation factor 5
chr1_+_20227480 0.641 PLA2G5
phospholipase A2, group V
chr4_-_164473107 0.640 NM_000909
NPY1R
neuropeptide Y receptor Y1
chr21_+_38550533 0.640 NM_002243
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr7_+_1239078 0.640 NM_001080461
UNCX
UNC homeobox

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.58 1.32e-02 GO:0007606 sensory perception of chemical stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.90 2.21e-03 GO:0045111 intermediate filament cytoskeleton
1.25 2.81e-03 GO:0005576 extracellular region
1.36 3.54e-03 GO:0044421 extracellular region part
1.97 2.20e-02 GO:0005681 spliceosomal complex
1.84 2.95e-02 GO:0005882 intermediate filament

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.59 1.25e-02 GO:0004984 olfactory receptor activity