Motif ID: AHR_ARNT_ARNT2.p2

Z-value: 2.550


Transcription factors associated with AHR_ARNT_ARNT2.p2:

Gene SymbolEntrez IDGene Name
AHR 196 aryl hydrocarbon receptor
ARNT 405 aryl hydrocarbon receptor nuclear translocator
ARNT2 9915 aryl-hydrocarbon receptor nuclear translocator 2



Activity profile for motif AHR_ARNT_ARNT2.p2.

activity profile for motif AHR_ARNT_ARNT2.p2


Sorted Z-values histogram for motif AHR_ARNT_ARNT2.p2

Sorted Z-values for motif AHR_ARNT_ARNT2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of AHR_ARNT_ARNT2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_6298284 4.717 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr21_-_38954433 3.895 ERG
v-ets erythroblastosis virus E26 oncogene homolog (avian)
chr3_-_162305319 3.662 NM_033169
NM_001038628
NM_003781
NM_033167
NM_033168
B3GALNT1




beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)




chr16_+_81218142 2.830 CDH13
cadherin 13, H-cadherin (heart)
chr3_-_129024665 2.826 NM_001003794
MGLL
monoglyceride lipase
chr11_-_78829342 2.700 NM_001098816
ODZ4
odz, odd Oz/ten-m homolog 4 (Drosophila)
chr19_-_61680510 2.688 NM_022103
ZNF667
zinc finger protein 667
chr22_-_17891777 2.657 CLDN5
claudin 5
chr12_-_87498225 2.654 NM_000899
NM_003994
KITLG

KIT ligand

chr9_-_25668230 2.608 TUSC1
tumor suppressor candidate 1
chr2_+_29191711 2.592 NM_024692
CLIP4
CAP-GLY domain containing linker protein family, member 4
chr4_-_57671112 2.552 IGFBP7
insulin-like growth factor binding protein 7
chr9_+_4480193 2.521 NM_004170
SLC1A1
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
chr13_-_32822759 2.472 STARD13
StAR-related lipid transfer (START) domain containing 13
chr13_-_77391525 2.451


chr1_+_199519202 2.439 NM_000299
NM_001005337
PKP1

plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)

chr16_+_81218074 2.408 NM_001257
CDH13
cadherin 13, H-cadherin (heart)
chr18_+_19523526 2.369 NM_001127717
NM_198129
LAMA3

laminin, alpha 3

chr5_-_159672060 2.261 NM_024565
CCNJL
cyclin J-like
chr4_-_57671273 2.196 NM_001553
IGFBP7
insulin-like growth factor binding protein 7
chr7_+_113513828 2.193 FOXP2
forkhead box P2
chr2_-_45090025 2.159 NM_016932
SIX2
SIX homeobox 2
chr4_-_57671307 2.156 IGFBP7
insulin-like growth factor binding protein 7
chr9_-_112381593 2.103 NM_153366
SVEP1
sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
chr20_+_13924014 1.941 NM_080676
MACROD2
MACRO domain containing 2
chr3_+_135996990 1.935 EPHB1
EPH receptor B1
chr5_+_60663842 1.915 NM_020928
ZSWIM6
zinc finger, SWIM-type containing 6
chr8_-_6680429 1.912 NM_207411
XKR5
XK, Kell blood group complex subunit-related family, member 5
chr10_+_105334704 1.906 NEURL
neuralized homolog (Drosophila)
chr1_+_110494654 1.900 NM_001010898
SLC6A17
solute carrier family 6, member 17
chr2_-_40532651 1.870 SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr1_+_77520874 1.857 NM_012093
AK5
adenylate kinase 5
chr3_-_62334229 1.808 NM_018008
FEZF2
FEZ family zinc finger 2
chr13_-_37341859 1.779 NM_001135955
NM_001135956
NM_001135957
NM_001135958
NM_003306
NM_016179
TRPC4





transient receptor potential cation channel, subfamily C, member 4





chr10_+_102782151 1.746 SFXN3
sideroflexin 3
chr6_+_21701942 1.720 NM_003107
SOX4
SRY (sex determining region Y)-box 4
chrX_-_83329562 1.664 NM_014496
RPS6KA6
ribosomal protein S6 kinase, 90kDa, polypeptide 6
chr4_-_143987053 1.661 NM_001101669
NM_003866
INPP4B

inositol polyphosphate-4-phosphatase, type II, 105kDa

chr12_+_58276114 1.660 SLC16A7
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
chr5_-_107034484 1.655 NM_001962
EFNA5
ephrin-A5
chr4_-_115120251 1.650 NM_024590
ARSJ
arylsulfatase family, member J
chr5_+_42459568 1.647 NM_000163
GHR
growth hormone receptor
chr10_+_124210980 1.624 NM_002775
HTRA1
HtrA serine peptidase 1
chr9_-_34579679 1.623 NM_001842
NM_147164
CNTFR

ciliary neurotrophic factor receptor

chr4_+_81337663 1.597 NM_001099403
PRDM8
PR domain containing 8
chr3_+_135996734 1.592 NM_004441
EPHB1
EPH receptor B1
chr20_+_13924263 1.580 MACROD2
MACRO domain containing 2
chr7_+_113513726 1.577 FOXP2
forkhead box P2
chr14_-_53491019 1.573 NM_130851
BMP4
bone morphogenetic protein 4
chr3_-_31997738 1.543 OSBPL10
oxysterol binding protein-like 10
chr2_+_219141546 1.542 RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr7_+_113513600 1.521 FOXP2
forkhead box P2
chr7_-_131911768 1.501 PLXNA4
plexin A4
chr18_-_5533967 1.479 NM_012307
EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr4_-_122063118 1.474 NM_018699
PRDM5
PR domain containing 5
chr9_-_83494198 1.460 TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr1_+_208472817 1.443 NM_019605
SERTAD4
SERTA domain containing 4
chr1_+_77520315 1.443 NM_174858
AK5
adenylate kinase 5
chr1_+_77520190 1.422 AK5
adenylate kinase 5
chrX_-_54401161 1.421 NM_001002838
NM_020922
WNK3

WNK lysine deficient protein kinase 3

chr16_-_85099941 1.388 LOC400550
hypothetical LOC400550
chr8_+_31616809 1.373 NM_013962
NRG1
neuregulin 1
chr20_+_41978195 1.368 NM_001098796
NM_032883
TOX2

TOX high mobility group box family member 2

chr1_+_32703225 1.358 NM_001145720
ZBTB8B
zinc finger and BTB domain containing 8B
chr18_-_21184824 1.356


chr7_-_27136876 1.354 NM_002141
HOXA4
homeobox A4
chr9_-_23816062 1.354 NM_004432
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr18_-_24011349 1.351 NM_001792
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr22_-_17892001 1.343 CLDN5
claudin 5
chr4_-_147079410 1.334


chr17_-_16413188 1.327 NM_020653
ZNF287
zinc finger protein 287
chr7_+_28415495 1.322 LOC401317
hypothetical LOC401317
chr1_-_58815415 1.316 TACSTD2
tumor-associated calcium signal transducer 2
chr10_+_102782156 1.306 SFXN3
sideroflexin 3
chr12_-_88269884 1.306 DUSP6
dual specificity phosphatase 6
chr14_+_60045621 1.297 NM_007374
SIX6
SIX homeobox 6
chr8_+_120497732 1.283 NM_002514
NOV
nephroblastoma overexpressed gene
chr3_-_172660545 1.278 NM_001161560
NM_001161561
NM_001161562
NM_001161563
NM_001161564
NM_001161565
NM_001161566
NM_015028
TNIK







TRAF2 and NCK interacting kinase







chr7_-_5535726 1.274 ACTB
actin, beta
chr10_-_49483002 1.273 NM_021226
ARHGAP22
Rho GTPase activating protein 22
chr15_-_61461127 1.270 NM_001218
NM_206925
CA12

carbonic anhydrase XII

chr5_-_172687798 1.268 STC2
stanniocalcin 2
chr3_+_64645819 1.265 LOC100507098
hypothetical LOC100507098
chr4_-_147079018 1.261 NM_178835
ZNF827
zinc finger protein 827
chr11_+_128266460 1.258 NM_000890
KCNJ5
potassium inwardly-rectifying channel, subfamily J, member 5
chr2_-_213111525 1.243 NM_001042599
NM_005235
ERBB4

v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)

chr3_-_31998241 1.216 NM_001174060
NM_017784
OSBPL10

oxysterol binding protein-like 10

chr13_-_39075200 1.215 LHFP
lipoma HMGIC fusion partner
chr3_+_106568430 1.203 ALCAM
activated leukocyte cell adhesion molecule
chr8_+_69026895 1.200 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr12_-_41269679 1.199 NM_153026
PRICKLE1
prickle homolog 1 (Drosophila)
chr4_-_10068055 1.187 NM_053042
ZNF518B
zinc finger protein 518B
chr7_-_27120015 1.184 HOXA3
homeobox A3
chr3_-_65999548 1.180 NM_001033057
NM_004742
NM_015520
MAGI1


membrane associated guanylate kinase, WW and PDZ domain containing 1


chr8_-_29262240 1.173 NM_057158
DUSP4
dual specificity phosphatase 4
chr3_+_106568334 1.172 NM_001627
ALCAM
activated leukocyte cell adhesion molecule
chr12_-_22378833 1.170 NM_003034
ST8SIA1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr13_-_39075304 1.168 LHFP
lipoma HMGIC fusion partner
chr8_-_125809831 1.167 NM_014751
MTSS1
metastasis suppressor 1
chr10_-_128884411 1.164 NM_001039762
FAM196A
family with sequence similarity 196, member A
chr2_+_206255376 1.160 NM_003872
NM_018534
NM_201264
NM_201266
NM_201267
NM_201279
NRP2





neuropilin 2





chr6_+_137285071 1.156 NM_001008783
SLC35D3
solute carrier family 35, member D3
chr16_+_22733307 1.155 NM_006043
HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr7_-_27149750 1.152 NM_019102
HOXA5
homeobox A5
chr15_-_80123935 1.147 MEX3B
mex-3 homolog B (C. elegans)
chr12_-_74710741 1.145 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr15_-_73719546 1.142 NM_018285
IMP3
IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast)
chr6_+_84619703 1.125 NM_001009994
RIPPLY2
ripply2 homolog (zebrafish)
chr6_-_10520592 1.119 NM_001032280
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr15_-_61460967 1.119 CA12
carbonic anhydrase XII
chr3_-_16530132 1.108 NM_015150
RFTN1
raftlin, lipid raft linker 1
chr9_-_85342868 1.106 NM_174938
FRMD3
FERM domain containing 3
chr9_+_86473273 1.105 NM_001018064
NM_006180
NTRK2

neurotrophic tyrosine kinase, receptor, type 2

chr8_+_69027277 1.096 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr8_-_97242119 1.091 NM_001001557
GDF6
growth differentiation factor 6
chr5_-_172688024 1.091 STC2
stanniocalcin 2
chr5_-_168660293 1.089 NM_003062
SLIT3
slit homolog 3 (Drosophila)
chr3_+_106568243 1.085 ALCAM
activated leukocyte cell adhesion molecule
chrX_+_21302317 1.076 NM_001168647
NM_001168648
NM_001168649
NM_014927
CNKSR2



connector enhancer of kinase suppressor of Ras 2



chr3_-_191321367 1.074 LEPREL1
leprecan-like 1
chr18_-_33399997 1.070 NM_001025087
NM_001025088
NM_001025089
NM_020180
CELF4



CUGBP, Elav-like family member 4



chr6_-_40663089 1.062 NM_020737
LRFN2
leucine rich repeat and fibronectin type III domain containing 2
chr3_-_135231417 1.061 SLCO2A1
solute carrier organic anion transporter family, member 2A1
chr19_-_2378581 1.058 TIMM13
translocase of inner mitochondrial membrane 13 homolog (yeast)
chrX_+_17303798 1.048 NHS
Nance-Horan syndrome (congenital cataracts and dental anomalies)
chr17_+_52026058 1.045 NM_005450
NOG
noggin
chr4_-_108176901 1.038 NM_014421
DKK2
dickkopf homolog 2 (Xenopus laevis)
chr15_+_72006015 1.021 LOXL1
lysyl oxidase-like 1
chr6_+_1336077 1.020


chr5_-_83715947 1.015 EDIL3
EGF-like repeats and discoidin I-like domains 3
chr17_-_60208083 1.015 LOC146880
hypothetical LOC146880
chr5_+_63497408 1.013 NM_001113561
NM_178532
RNF180

ring finger protein 180

chr8_+_69027166 0.993 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr8_-_26427304 0.993 NM_007257
PNMA2
paraneoplastic antigen MA2
chr4_+_158361185 0.982 NM_000826
NM_001083619
NM_001083620
GRIA2


glutamate receptor, ionotropic, AMPA 2


chrX_-_107866262 0.977 NM_003604
IRS4
insulin receptor substrate 4
chr1_+_182040837 0.971 RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr22_-_44828636 0.971 NM_018280
C22orf26
chromosome 22 open reading frame 26
chr10_+_105243724 0.968 NM_004210
NEURL
neuralized homolog (Drosophila)
chr15_-_43602293 0.967 NM_013309
SLC30A4
solute carrier family 30 (zinc transporter), member 4
chr16_+_22732982 0.964 HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr7_-_131911808 0.961 NM_001105543
NM_020911
PLXNA4

plexin A4

chr12_-_70953461 0.958 LOC283392
hypothetical LOC283392
chr11_-_44928803 0.956 NM_001076787
NM_006034
TP53I11

tumor protein p53 inducible protein 11

chr6_-_10520264 0.955 TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr2_+_219991342 0.955 NM_001927
DES
desmin
chr4_-_55686503 0.952 NM_002253
KDR
kinase insert domain receptor (a type III receptor tyrosine kinase)
chr3_+_31998269 0.951 NM_001137674
ZNF860
zinc finger protein 860
chr8_+_59069522 0.945 NM_147189
FAM110B
family with sequence similarity 110, member B
chr10_-_35970363 0.942 NM_031866
FZD8
frizzled homolog 8 (Drosophila)
chr1_-_85703321 0.940 NM_012137
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr7_+_98084531 0.937 NM_002523
NPTX2
neuronal pentraxin II
chr8_-_24869945 0.936 NM_006158
NEFL
neurofilament, light polypeptide
chr6_-_42527760 0.931 NM_033502
TRERF1
transcriptional regulating factor 1
chr14_-_73106243 0.929


chr10_+_124211353 0.928 HTRA1
HtrA serine peptidase 1
chr7_-_84654106 0.922 SEMA3D
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr15_+_67009892 0.920 NM_145658
NM_001184780
SPESP1
NOX5
sperm equatorial segment protein 1
NADPH oxidase, EF-hand calcium binding domain 5
chr5_-_134942346 0.917 CXCL14
chemokine (C-X-C motif) ligand 14
chr3_+_189354167 0.915 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr9_-_109290528 0.915 KLF4
Kruppel-like factor 4 (gut)
chr13_-_77390907 0.911 NM_001122659
NM_003991
EDNRB

endothelin receptor type B

chr11_+_66827563 0.909 SSH3
slingshot homolog 3 (Drosophila)
chr5_-_83716346 0.907 NM_005711
EDIL3
EGF-like repeats and discoidin I-like domains 3
chr4_+_156808261 0.903 NM_001130684
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr8_+_69027143 0.902 NM_024870
NM_025170
PREX2

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2

chr11_+_112337491 0.895 NCAM1
neural cell adhesion molecule 1
chr5_+_49998677 0.894 PARP8
poly (ADP-ribose) polymerase family, member 8
chr1_+_199975674 0.893 NAV1
neuron navigator 1
chr8_+_1759502 0.893 NM_014629
ARHGEF10
Rho guanine nucleotide exchange factor (GEF) 10
chr12_+_81604752 0.893 TMTC2
transmembrane and tetratricopeptide repeat containing 2
chr12_+_70952729 0.891 NM_013381
TRHDE
thyrotropin-releasing hormone degrading enzyme
chr13_-_43259032 0.888 NM_017993
ENOX1
ecto-NOX disulfide-thiol exchanger 1
chr11_+_106967165 0.886 ELMOD1
ELMO/CED-12 domain containing 1
chr12_+_81605032 0.885 NM_152588
TMTC2
transmembrane and tetratricopeptide repeat containing 2
chr19_-_2378530 0.883 TIMM13
translocase of inner mitochondrial membrane 13 homolog (yeast)
chr19_+_38804694 0.879 NM_001127895
NM_001127896
CHST8

carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8

chr8_+_32525269 0.869 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
NRG1










neuregulin 1










chr6_+_133604181 0.869 NM_004100
NM_172103
NM_172105
EYA4


eyes absent homolog 4 (Drosophila)


chr7_-_15692551 0.867 MEOX2
mesenchyme homeobox 2
chr16_+_54070302 0.865 NM_004530
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr6_+_133604203 0.865 EYA4
eyes absent homolog 4 (Drosophila)
chr12_+_81605289 0.865 TMTC2
transmembrane and tetratricopeptide repeat containing 2
chr8_-_125809559 0.864 MTSS1
metastasis suppressor 1
chr3_+_30623376 0.861 TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr1_-_16355013 0.855 NM_004431
EPHA2
EPH receptor A2
chr15_+_99276982 0.853 NM_024652
LRRK1
leucine-rich repeat kinase 1
chr8_-_60194099 0.852 NM_014729
TOX
thymocyte selection-associated high mobility group box
chr1_+_64709063 0.848 NM_020925
CACHD1
cache domain containing 1
chr5_-_134942867 0.847 NM_004887
CXCL14
chemokine (C-X-C motif) ligand 14
chr15_+_81907176 0.843 SH3GL3
SH3-domain GRB2-like 3
chr12_+_64504835 0.843 HMGA2
high mobility group AT-hook 2
chr2_+_219141761 0.837 NM_005444
RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr22_-_36153449 0.837 NM_052906
ELFN2
extracellular leucine-rich repeat and fibronectin type III domain containing 2
chr11_+_106967017 0.834 NM_001130037
NM_018712
ELMOD1

ELMO/CED-12 domain containing 1

chr11_+_106967283 0.832 ELMOD1
ELMO/CED-12 domain containing 1
chrX_-_106129854 0.830 MORC4
MORC family CW-type zinc finger 4
chr6_-_48144344 0.829 NM_001013732
NM_207499
C6orf138

chromosome 6 open reading frame 138

chr17_-_959007 0.826 NM_001092
ABR
active BCR-related gene
chr2_-_219141199 0.824 NM_020935
USP37
ubiquitin specific peptidase 37

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.60 1.58e-13 GO:0007399 nervous system development
1.21 4.43e-13 GO:0050794 regulation of cellular process
1.33 1.89e-11 GO:0007275 multicellular organismal development
1.12 2.58e-11 GO:0009987 cellular process
1.34 5.53e-11 GO:0048856 anatomical structure development
1.37 5.61e-11 GO:0048731 system development
1.30 1.16e-10 GO:0032502 developmental process
1.18 8.86e-10 GO:0050789 regulation of biological process
1.16 3.31e-09 GO:0065007 biological regulation
1.73 4.88e-08 GO:0045595 regulation of cell differentiation
1.32 1.16e-07 GO:0071841 cellular component organization or biogenesis at cellular level
1.68 1.26e-07 GO:2000026 regulation of multicellular organismal development
1.33 1.52e-07 GO:0071842 cellular component organization at cellular level
1.62 2.03e-07 GO:0048699 generation of neurons
1.60 2.14e-07 GO:0022008 neurogenesis
1.60 2.38e-07 GO:0050793 regulation of developmental process
1.45 2.67e-07 GO:0009653 anatomical structure morphogenesis
1.28 3.48e-07 GO:0060255 regulation of macromolecule metabolic process
1.31 6.55e-07 GO:0048518 positive regulation of biological process
2.01 1.52e-06 GO:0060284 regulation of cell development
1.26 1.68e-06 GO:0071840 cellular component organization or biogenesis
1.26 2.48e-06 GO:0016043 cellular component organization
1.25 2.55e-06 GO:0031323 regulation of cellular metabolic process
1.77 2.61e-06 GO:0007417 central nervous system development
1.25 2.92e-06 GO:0023052 signaling
1.46 4.20e-06 GO:0009893 positive regulation of metabolic process
1.25 4.20e-06 GO:0080090 regulation of primary metabolic process
1.37 4.30e-06 GO:0010467 gene expression
1.22 5.69e-06 GO:0044260 cellular macromolecule metabolic process
1.31 7.54e-06 GO:0048522 positive regulation of cellular process
1.23 1.16e-05 GO:0019222 regulation of metabolic process
1.38 2.04e-05 GO:0023051 regulation of signaling
1.33 2.10e-05 GO:0048523 negative regulation of cellular process
1.61 2.28e-05 GO:0009790 embryo development
1.43 2.39e-05 GO:0051239 regulation of multicellular organismal process
1.46 2.61e-05 GO:0010604 positive regulation of macromolecule metabolic process
1.73 2.94e-05 GO:0000904 cell morphogenesis involved in differentiation
1.33 4.39e-05 GO:0030154 cell differentiation
1.32 4.41e-05 GO:0048869 cellular developmental process
1.95 5.79e-05 GO:0051270 regulation of cellular component movement
1.62 5.83e-05 GO:0030030 cell projection organization
1.91 6.15e-05 GO:0022603 regulation of anatomical structure morphogenesis
1.49 6.34e-05 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.29 8.54e-05 GO:0048519 negative regulation of biological process
1.33 1.24e-04 GO:0048513 organ development
1.27 1.27e-04 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.63 1.40e-04 GO:0000902 cell morphogenesis
1.49 1.43e-04 GO:0048468 cell development
1.23 1.91e-04 GO:0051179 localization
1.57 2.62e-04 GO:0010628 positive regulation of gene expression
1.56 2.71e-04 GO:0030182 neuron differentiation
1.85 2.86e-04 GO:0001501 skeletal system development
1.15 3.60e-04 GO:0044237 cellular metabolic process
1.41 4.48e-04 GO:0031325 positive regulation of cellular metabolic process
1.70 5.05e-04 GO:0051094 positive regulation of developmental process
1.70 5.18e-04 GO:0007268 synaptic transmission
1.87 6.00e-04 GO:0040012 regulation of locomotion
1.33 6.13e-04 GO:0009059 macromolecule biosynthetic process
2.84 6.17e-04 GO:0010563 negative regulation of phosphorus metabolic process
2.84 6.17e-04 GO:0045936 negative regulation of phosphate metabolic process
1.37 6.21e-04 GO:0009966 regulation of signal transduction
1.92 6.31e-04 GO:0030334 regulation of cell migration
1.77 7.14e-04 GO:0007420 brain development
1.23 8.01e-04 GO:0034641 cellular nitrogen compound metabolic process
1.61 8.55e-04 GO:0006928 cellular component movement
1.33 9.76e-04 GO:0034645 cellular macromolecule biosynthetic process
1.90 1.02e-03 GO:2000145 regulation of cell motility
1.22 1.26e-03 GO:0007165 signal transduction
1.44 1.36e-03 GO:0032774 RNA biosynthetic process
1.56 1.48e-03 GO:0045893 positive regulation of transcription, DNA-dependent
2.30 1.56e-03 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.55 1.64e-03 GO:0032989 cellular component morphogenesis
1.63 1.70e-03 GO:0031175 neuron projection development
2.04 1.70e-03 GO:0048732 gland development
1.77 1.79e-03 GO:0045597 positive regulation of cell differentiation
1.50 1.91e-03 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.50 1.91e-03 GO:0010557 positive regulation of macromolecule biosynthetic process
2.28 1.97e-03 GO:0022604 regulation of cell morphogenesis
1.41 2.23e-03 GO:0010646 regulation of cell communication
1.16 2.25e-03 GO:0043170 macromolecule metabolic process
1.21 2.28e-03 GO:0006807 nitrogen compound metabolic process
1.47 2.35e-03 GO:0051128 regulation of cellular component organization
6.03 2.45e-03 GO:0010771 negative regulation of cell morphogenesis involved in differentiation
1.49 2.46e-03 GO:0007267 cell-cell signaling
1.53 2.47e-03 GO:0051254 positive regulation of RNA metabolic process
2.79 2.63e-03 GO:0042326 negative regulation of phosphorylation
2.19 3.37e-03 GO:0050678 regulation of epithelial cell proliferation
1.31 3.37e-03 GO:0016070 RNA metabolic process
2.06 3.65e-03 GO:0030900 forebrain development
1.65 4.23e-03 GO:0048667 cell morphogenesis involved in neuron differentiation
1.45 5.08e-03 GO:0009891 positive regulation of biosynthetic process
1.60 5.23e-03 GO:0019226 transmission of nerve impulse
1.60 5.23e-03 GO:0035637 multicellular organismal signaling
1.24 5.41e-03 GO:0010468 regulation of gene expression
1.65 6.00e-03 GO:0007409 axonogenesis
1.24 6.08e-03 GO:0009058 biosynthetic process
1.46 6.62e-03 GO:0051173 positive regulation of nitrogen compound metabolic process
1.69 6.99e-03 GO:0048598 embryonic morphogenesis
1.49 7.12e-03 GO:0019220 regulation of phosphate metabolic process
1.49 7.12e-03 GO:0051174 regulation of phosphorus metabolic process
1.23 7.32e-03 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.44 7.74e-03 GO:0031328 positive regulation of cellular biosynthetic process
1.71 7.90e-03 GO:0003006 developmental process involved in reproduction
1.58 8.02e-03 GO:0048858 cell projection morphogenesis
2.24 8.02e-03 GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
1.94 8.13e-03 GO:0045664 regulation of neuron differentiation
1.40 8.38e-03 GO:0032879 regulation of localization
2.18 8.73e-03 GO:0048705 skeletal system morphogenesis
2.49 8.81e-03 GO:0051271 negative regulation of cellular component movement
1.62 9.09e-03 GO:0048812 neuron projection morphogenesis
1.24 9.70e-03 GO:0044249 cellular biosynthetic process
1.43 1.01e-02 GO:0040011 locomotion
1.83 1.06e-02 GO:0030036 actin cytoskeleton organization
1.53 1.08e-02 GO:0048666 neuron development
1.57 1.19e-02 GO:0032990 cell part morphogenesis
1.59 1.22e-02 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.76 1.29e-02 GO:0001944 vasculature development
2.49 1.31e-02 GO:0060485 mesenchyme development
2.08 1.37e-02 GO:0045165 cell fate commitment
1.42 1.44e-02 GO:0006351 transcription, DNA-dependent
2.22 1.48e-02 GO:0006469 negative regulation of protein kinase activity
3.69 1.61e-02 GO:0007044 cell-substrate junction assembly
3.69 1.61e-02 GO:0010717 regulation of epithelial to mesenchymal transition
1.24 1.62e-02 GO:0051252 regulation of RNA metabolic process
1.22 1.64e-02 GO:0051171 regulation of nitrogen compound metabolic process
1.74 1.90e-02 GO:0030029 actin filament-based process
1.48 1.99e-02 GO:0042325 regulation of phosphorylation
1.37 2.05e-02 GO:0051246 regulation of protein metabolic process
1.41 2.17e-02 GO:0009888 tissue development
6.45 2.21e-02 GO:0010719 negative regulation of epithelial to mesenchymal transition
1.22 2.31e-02 GO:0009889 regulation of biosynthetic process
1.78 2.31e-02 GO:0045596 negative regulation of cell differentiation
1.22 2.32e-02 GO:0031326 regulation of cellular biosynthetic process
1.53 2.64e-02 GO:0051253 negative regulation of RNA metabolic process
1.83 2.85e-02 GO:0002009 morphogenesis of an epithelium
1.50 2.91e-02 GO:0009887 organ morphogenesis
1.12 3.16e-02 GO:0044238 primary metabolic process
1.84 3.17e-02 GO:0048514 blood vessel morphogenesis
1.74 3.43e-02 GO:0051960 regulation of nervous system development
2.46 3.82e-02 GO:0050679 positive regulation of epithelial cell proliferation
1.75 3.92e-02 GO:0001568 blood vessel development
1.46 4.15e-02 GO:0031327 negative regulation of cellular biosynthetic process
1.24 4.22e-02 GO:0090304 nucleic acid metabolic process
1.67 4.29e-02 GO:0051093 negative regulation of developmental process
2.49 4.37e-02 GO:2000027 regulation of organ morphogenesis
1.45 4.41e-02 GO:0009890 negative regulation of biosynthetic process
2.67 4.56e-02 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
1.42 4.58e-02 GO:0031399 regulation of protein modification process
1.22 4.59e-02 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.36 4.73e-02 GO:0007154 cell communication
1.47 4.74e-02 GO:0001932 regulation of protein phosphorylation
1.53 4.81e-02 GO:0007010 cytoskeleton organization
1.62 4.85e-02 GO:0043009 chordate embryonic development
1.22 4.92e-02 GO:0044267 cellular protein metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.14 2.77e-20 GO:0005622 intracellular
1.13 3.61e-16 GO:0044424 intracellular part
1.14 1.18e-12 GO:0043226 organelle
1.14 2.31e-12 GO:0043229 intracellular organelle
1.22 9.21e-11 GO:0005634 nucleus
1.15 1.27e-10 GO:0043231 intracellular membrane-bounded organelle
1.15 1.35e-10 GO:0005737 cytoplasm
1.15 1.36e-10 GO:0043227 membrane-bounded organelle
1.05 7.81e-09 GO:0044464 cell part
1.05 8.27e-09 GO:0005623 cell
1.26 3.91e-04 GO:0070013 intracellular organelle lumen
1.25 4.67e-04 GO:0031974 membrane-enclosed lumen
1.29 7.04e-04 GO:0031981 nuclear lumen
1.25 8.12e-04 GO:0043233 organelle lumen
1.13 1.94e-03 GO:0044444 cytoplasmic part
1.13 2.91e-03 GO:0044446 intracellular organelle part
1.13 4.07e-03 GO:0044422 organelle part
1.30 8.66e-03 GO:0005654 nucleoplasm
1.46 8.67e-03 GO:0030054 cell junction
1.57 8.85e-03 GO:0043005 neuron projection
1.93 1.65e-02 GO:0005912 adherens junction
1.88 1.72e-02 GO:0070161 anchoring junction
1.22 1.76e-02 GO:0044428 nuclear part
1.19 2.38e-02 GO:0043228 non-membrane-bounded organelle
1.19 2.38e-02 GO:0043232 intracellular non-membrane-bounded organelle
1.76 3.52e-02 GO:0005911 cell-cell junction
1.79 4.53e-02 GO:0030424 axon

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.10 3.07e-10 GO:0005488 binding
1.15 6.84e-07 GO:0005515 protein binding
1.47 1.45e-05 GO:0030528 transcription regulator activity
1.26 3.70e-04 GO:0000166 nucleotide binding
1.21 5.40e-04 GO:0003676 nucleic acid binding
1.41 6.79e-04 GO:0001071 nucleic acid binding transcription factor activity
1.41 6.79e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
1.47 3.40e-03 GO:0043565 sequence-specific DNA binding
1.63 6.80e-03 GO:0005525 GTP binding
1.68 1.10e-02 GO:0008134 transcription factor binding
1.58 2.15e-02 GO:0019001 guanyl nucleotide binding
1.58 2.15e-02 GO:0032561 guanyl ribonucleotide binding