Motif ID: REST.p3

Z-value: 1.712


Transcription factors associated with REST.p3:

Gene SymbolEntrez IDGene Name
REST 5978 RE1-silencing transcription factor



Activity profile for motif REST.p3.

activity profile for motif REST.p3


Sorted Z-values histogram for motif REST.p3

Sorted Z-values for motif REST.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of REST.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_99599984 2.947 NM_001010917
GOLGA7B
golgin A7 family, member B
chr3_+_9720509 2.809 NM_153635
CPNE9
copine family member IX
chr8_-_91164100 2.544 NM_004929
CALB1
calbindin 1, 28kDa
chr20_-_61755145 2.432 NM_015894
STMN3
stathmin-like 3
chr12_-_3472245 2.286 LOC100129223
hypothetical LOC100129223
chr7_+_154943466 2.242 NM_001427
EN2
engrailed homeobox 2
chr12_+_46133 2.183 NM_001170738
IQSEC3
IQ motif and Sec7 domain 3
chr20_+_61798512 2.134 TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr6_+_158877455 2.124 NM_020823
TMEM181
transmembrane protein 181
chr6_+_158877640 2.077 TMEM181
transmembrane protein 181
chr20_+_5839973 2.048 NM_001819
CHGB
chromogranin B (secretogranin 1)
chr20_+_61798446 1.866 NM_003823
TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr15_-_81175542 1.836 NM_004644
AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr12_-_29828958 1.797 NM_175861
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr16_+_66244314 1.718 RLTPR
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr1_+_152806924 1.594 CHRNB2
cholinergic receptor, nicotinic, beta 2 (neuronal)
chr17_+_39741306 1.564 NM_001144825
NM_001144826
NM_006695
RUNDC3A


RUN domain containing 3A


chr7_+_145444385 1.560 NM_014141
CNTNAP2
contactin associated protein-like 2
chr1_-_207892420 1.504 NM_000228
LAMB3
laminin, beta 3
chr1_+_152806874 1.451 NM_000748
CHRNB2
cholinergic receptor, nicotinic, beta 2 (neuronal)
chr8_-_145723209 1.432 NM_001024678
LRRC24
leucine rich repeat containing 24
chr7_-_100595552 1.332 NM_003378
VGF
VGF nerve growth factor inducible
chr4_-_175986952 1.315 NM_001042543
NM_006529
GLRA3

glycine receptor, alpha 3

chrX_-_47364039 1.246


chr20_+_30019465 1.210 NM_001011718
XKR7
XK, Kell blood group complex subunit-related family, member 7
chr6_+_35881048 1.140 NM_182548
LHFPL5
lipoma HMGIC fusion partner-like 5
chr11_-_123030091 1.129 SCN3B
sodium channel, voltage-gated, type III, beta
chr3_-_133236447 1.119 NM_130808
CPNE4
copine IV
chrX_-_47364173 1.100 NM_006950
NM_133499
SYN1

synapsin I

chr7_+_8440541 1.070 NXPH1
neurexophilin 1
chr1_-_33108876 0.960 NM_001171940
NM_153756
FNDC5

fibronectin type III domain containing 5

chr18_-_5187240 0.923 NM_001145194
LOC642597
hypothetical protein LOC642597
chr6_+_25760352 0.909 NM_006998
SCGN
secretagogin, EF-hand calcium binding protein
chr19_+_38867273 0.890 NM_022467
CHST8
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
chr4_+_8633116 0.878 NM_080819
GPR78
G protein-coupled receptor 78
chr1_+_33124658 0.877 NM_002143
HPCA
hippocalcin
chr16_+_2959362 0.865 PAQR4
progestin and adipoQ receptor family member IV
chr3_-_48675321 0.843 NM_001407
CELSR3
cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)
chr7_+_8440109 0.790 NM_152745
NXPH1
neurexophilin 1
chr19_-_45416043 0.781 TTC9B
tetratricopeptide repeat domain 9B
chr16_+_2959342 0.774 NM_152341
PAQR4
progestin and adipoQ receptor family member IV
chr7_+_8439762 0.745 NXPH1
neurexophilin 1
chr17_-_24265108 0.689 PHF12
PHD finger protein 12
chr2_+_131230252 0.686 NM_001105194
NM_001105195
FAM123C

family with sequence similarity 123C

chr17_-_24357014 0.646 NM_001098635
NM_178860
SEZ6

seizure related 6 homolog (mouse)

chr9_-_138236775 0.619 NM_178138
LHX3
LIM homeobox 3
chr19_-_60383280 0.602 NM_003180
SYT5
synaptotagmin V
chr11_-_1725924 0.590 NM_001170820
LOC402778
CD225 family protein FLJ76511
chr6_+_110406890 0.557 NM_005284
GPR6
G protein-coupled receptor 6
chr8_-_145530639 0.541 NM_031309
SCRT1
scratch homolog 1, zinc finger protein (Drosophila)
chr3_-_115380539 0.537 NM_000796
NM_033663
DRD3

dopamine receptor D3

chr9_+_130078321 0.523 C9orf119
chromosome 9 open reading frame 119
chr14_-_104142125 0.510 NM_207379
TMEM179
transmembrane protein 179
chr9_+_139153409 0.497 NM_000832
NM_001185090
NM_001185091
NM_007327
NM_021569
GRIN1




glutamate receptor, ionotropic, N-methyl D-aspartate 1




chr12_+_112280753 0.485 NM_001159727
NM_173542
PLBD2

phospholipase B domain containing 2

chr7_-_19778928 0.482 NM_152774
TMEM196
transmembrane protein 196
chr11_-_1725662 0.482 LOC402778
CD225 family protein FLJ76511
chr12_+_112280757 0.481 PLBD2
phospholipase B domain containing 2
chr1_-_23393808 0.470 NM_000864
HTR1D
5-hydroxytryptamine (serotonin) receptor 1D
chr14_+_92459197 0.466 NM_001275
CHGA
chromogranin A (parathyroid secretory protein 1)
chr9_+_130078242 0.453 NM_001040011
C9orf119
chromosome 9 open reading frame 119
chr15_+_65904994 0.447 NM_001031807
SKOR1
SKI family transcriptional corepressor 1
chr11_+_45863774 0.437 NM_005456
MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1
chr2_-_27384617 0.413 NM_003353
UCN
urocortin
chr16_+_4948318 0.412 NM_014692
SEC14L5
SEC14-like 5 (S. cerevisiae)
chr9_-_73251639 0.386 TRPM3
transient receptor potential cation channel, subfamily M, member 3
chr19_+_9064854 0.384 NM_001004456
OR1M1
olfactory receptor, family 1, subfamily M, member 1
chr15_+_73074882 0.383 NM_001178111
NM_001178112
NM_138967
SCAMP5


secretory carrier membrane protein 5


chr6_+_153113624 0.379 NM_003381
NM_194435
VIP

vasoactive intestinal peptide

chr8_-_57521065 0.365 NM_006211
PENK
proenkephalin
chr10_+_69990050 0.354 NM_030625
TET1
tet oncogene 1
chr17_-_77474597 0.333 NM_032711
MAFG
v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)
chr19_-_50618599 0.331 ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr19_+_4720144 0.324 C19orf30
chromosome 19 open reading frame 30
chr19_-_44427446 0.319 NM_172139
IL28B
interleukin 28B (interferon, lambda 3)
chr5_-_135729062 0.317 NM_001167576
NM_001167577
NM_020389
TRPC7


transient receptor potential cation channel, subfamily C, member 7


chr1_+_208178198 0.307 SYT14
synaptotagmin XIV
chr3_+_195336631 0.304 HES1
hairy and enhancer of split 1, (Drosophila)
chr10_-_50640327 0.302 NM_001143996
NM_001143997
NM_018245
OGDHL


oxoglutarate dehydrogenase-like


chr2_+_207215386 0.300 NM_001102659
LOC200726
hCG1657980
chr1_-_149955870 0.290 NM_007185
CELF3
CUGBP, Elav-like family member 3
chr16_+_24174975 0.287 CACNG3
calcium channel, voltage-dependent, gamma subunit 3
chr16_+_2450081 0.275 NM_025108
C16orf59
chromosome 16 open reading frame 59
chr8_+_6553278 0.274 NM_018361
AGPAT5
1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)
chr22_+_18388656 0.272 C22orf25
chromosome 22 open reading frame 25
chr3_+_62280435 0.269 NM_020685
C3orf14
chromosome 3 open reading frame 14
chr12_+_111713931 0.267 NM_001143854
NM_014954
RPH3A

rabphilin 3A homolog (mouse)

chr22_+_18388602 0.262 NM_152906
C22orf25
chromosome 22 open reading frame 25
chr20_-_60228665 0.253 NM_007232
HRH3
histamine receptor H3
chr9_-_130078017 0.248 NM_004486
GOLGA2
golgin A2
chr22_+_18388633 0.239 C22orf25
chromosome 22 open reading frame 25
chr1_-_102235377 0.239 NM_058170
OLFM3
olfactomedin 3
chr8_+_57520915 0.239


chr19_+_45728270 0.237 SPTBN4
spectrin, beta, non-erythrocytic 4
chr1_+_208178160 0.233 NM_001146261
NM_001146262
NM_001146264
NM_153262
SYT14



synaptotagmin XIV



chr19_-_50618659 0.232 NM_202001
ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr10_+_73225533 0.230 NM_001171933
NM_001171934
CDH23

cadherin-related 23

chr17_-_37022465 0.225 NM_005557
KRT16
keratin 16
chr9_+_137593420 0.217 NM_001018049
NM_002571
PAEP

progestagen-associated endometrial protein

chr11_-_122357545 0.214 NM_001098169
BSX
brain-specific homeobox
chr1_-_102234959 0.212 OLFM3
olfactomedin 3
chr6_-_32121784 0.205 NM_032470
TNXB
tenascin XB
chr10_+_60607232 0.200 NM_001143774
PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein-like
chr9_+_116131889 0.191 NM_000608
ORM2
orosomucoid 2
chr17_+_27838041 0.190 NM_003885
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr19_-_45416112 0.188 NM_152479
TTC9B
tetratricopeptide repeat domain 9B
chr11_-_74819165 0.183 NM_001039548
KLHL35
kelch-like 35 (Drosophila)
chr9_-_103397023 0.181 NM_147180
PPP3R2
protein phosphatase 3, regulatory subunit B, beta
chr3_+_195336625 0.176 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr10_+_28862068 0.171


chr3_-_188870799 0.168 NM_001048
SST
somatostatin
chr12_+_111714096 0.167 RPH3A
rabphilin 3A homolog (mouse)
chr15_+_67009892 0.166 NM_145658
NM_001184780
SPESP1
NOX5
sperm equatorial segment protein 1
NADPH oxidase, EF-hand calcium binding domain 5
chrX_-_48943582 0.147 NM_003179
SYP
synaptophysin
chr2_-_51112743 0.144 NRXN1
neurexin 1
chr11_-_27698800 0.139 NM_001143805
NM_001143806
NM_170732
BDNF


brain-derived neurotrophic factor


chr5_+_141283550 0.136 NM_001142603
NM_014773
KIAA0141

KIAA0141

chr2_-_51113040 0.130 NM_001135659
NM_004801
NRXN1

neurexin 1

chr19_+_45728207 0.126 NM_025213
SPTBN4
spectrin, beta, non-erythrocytic 4
chr6_+_138767007 0.114 NM_014320
HEBP2
heme binding protein 2
chr5_-_175969697 0.114 NM_052899
GPRIN1
G protein regulated inducer of neurite outgrowth 1
chr10_+_28861730 0.113


chr1_+_1836125 0.111 NM_138705
CALML6
calmodulin-like 6
chr18_-_53404783 0.110 NM_000140
NM_001012515
FECH

ferrochelatase

chr19_-_50429306 0.106 NM_138568
EXOC3L2
exocyst complex component 3-like 2
chr8_+_6553322 0.102 AGPAT5
1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)
chr17_+_70178850 0.100 NM_175738
RAB37
RAB37, member RAS oncogene family
chr8_+_80685859 0.099 STMN2
stathmin-like 2
chr3_+_122109716 0.098 NM_014980
STXBP5L
syntaxin binding protein 5-like
chr17_+_77925441 0.095 NM_018949
UTS2R
urotensin 2 receptor
chr5_+_141283647 0.094 KIAA0141
KIAA0141
chr11_-_65871592 0.090 NM_006876
B3GNT1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
chr15_-_70399181 0.090 CELF6
CUGBP, Elav-like family member 6
chr6_+_138767151 0.086 HEBP2
heme binding protein 2
chr4_+_158361185 0.084 NM_000826
NM_001083619
NM_001083620
GRIA2


glutamate receptor, ionotropic, AMPA 2


chr17_-_3546236 0.079 NM_002561
NM_175080
NM_175081
P2RX5-TAX1BP3
P2RX5


P2RX5-TAX1BP3 read-through transcript
purinergic receptor P2X, ligand-gated ion channel, 5


chr1_-_239749634 0.076 FH
fumarate hydratase
chr1_-_239749683 0.076 NM_000143
FH
fumarate hydratase
chr19_+_15058790 0.063 NM_001004713
OR1I1
olfactory receptor, family 1, subfamily I, member 1
chr16_+_24175173 0.059 CACNG3
calcium channel, voltage-dependent, gamma subunit 3
chr1_-_20707196 0.055 NM_024544
MUL1
mitochondrial E3 ubiquitin protein ligase 1
chr21_-_34749908 0.052 NM_001127670
KCNE1
potassium voltage-gated channel, Isk-related family, member 1
chr19_-_3922089 0.050 DAPK3
death-associated protein kinase 3
chr12_-_29827952 0.047 NM_001193451
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr17_-_3248453 0.047 NM_003553
OR1E1
olfactory receptor, family 1, subfamily E, member 1
chr20_+_35445350 0.045 SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr3_+_52787478 0.044 NM_001166434
ITIH1
inter-alpha (globulin) inhibitor H1
chr11_-_74818858 0.035 KLHL35
kelch-like 35 (Drosophila)
chr5_+_71050745 0.031 NM_004291
CARTPT
CART prepropeptide
chr14_+_92459244 0.029 CHGA
chromogranin A (parathyroid secretory protein 1)
chr1_-_20707103 0.029 MUL1
mitochondrial E3 ubiquitin protein ligase 1
chr1_-_151390050 0.028 NM_001014291
SPRR2G
small proline-rich protein 2G
chr6_+_154402135 0.027 NM_000914
NM_001008503
NM_001008504
NM_001008505
NM_001145282
NM_001145283
NM_001145285
NM_001145286
NM_001145284
OPRM1








opioid receptor, mu 1








chr12_+_117903682 0.026 NM_194286
SRRM4
serine/arginine repetitive matrix 4
chr6_+_43257883 0.022 NM_015089
CUL9
cullin 9
chr16_+_67902751 0.015 NM_013245
VPS4A
vacuolar protein sorting 4 homolog A (S. cerevisiae)
chr22_-_16636748 0.011 NM_197966
BID
BH3 interacting domain death agonist
chr19_-_3922032 0.009 DAPK3
death-associated protein kinase 3
chr17_-_7159094 0.009 NM_004489
GPS2
G protein pathway suppressor 2
chr5_+_175231210 0.005 CPLX2
complexin 2
chr11_+_64565118 0.004 SAC3D1
SAC3 domain containing 1
chr6_+_43257903 0.002 CUL9
cullin 9

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
5.45 2.11e-05 GO:0019226 transmission of nerve impulse
5.45 2.11e-05 GO:0035637 multicellular organismal signaling
5.74 2.99e-05 GO:0007268 synaptic transmission
6.82 3.38e-05 GO:0007610 behavior
3.07 2.04e-04 GO:0050877 neurological system process
2.76 3.18e-04 GO:0003008 system process
1.77 7.33e-04 GO:0032501 multicellular organismal process
8.89 1.97e-03 GO:0031644 regulation of neurological system process
4.26 3.01e-03 GO:0007186 G-protein coupled receptor protein signaling pathway
3.54 6.26e-03 GO:0007267 cell-cell signaling
4.54 7.97e-03 GO:0046903 secretion
8.59 1.03e-02 GO:0051969 regulation of transmission of nerve impulse
23.39 1.40e-02 GO:0050433 regulation of catecholamine secretion
22.53 1.63e-02 GO:0045776 negative regulation of blood pressure
6.51 1.91e-02 GO:0003013 circulatory system process
6.51 1.91e-02 GO:0008015 blood circulation
4.91 2.21e-02 GO:0044057 regulation of system process
8.86 3.53e-02 GO:0008217 regulation of blood pressure
11.52 4.29e-02 GO:0007631 feeding behavior
8.53 4.37e-02 GO:0007611 learning or memory
4.10 4.66e-02 GO:0055082 cellular chemical homeostasis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
5.88 1.03e-03 GO:0030659 cytoplasmic vesicle membrane
4.76 1.08e-03 GO:0043005 neuron projection
4.72 1.16e-03 GO:0045202 synapse
3.55 1.32e-03 GO:0016023 cytoplasmic membrane-bounded vesicle
5.68 1.39e-03 GO:0012506 vesicle membrane
16.90 1.44e-03 GO:0030672 synaptic vesicle membrane
3.49 1.67e-03 GO:0031988 membrane-bounded vesicle
7.12 2.20e-03 GO:0043025 neuronal cell body
5.31 2.52e-03 GO:0044456 synapse part
10.74 2.61e-03 GO:0030665 clathrin coated vesicle membrane
6.92 2.71e-03 GO:0044297 cell body
10.61 2.79e-03 GO:0008021 synaptic vesicle
3.35 2.80e-03 GO:0031410 cytoplasmic vesicle
3.24 4.15e-03 GO:0031982 vesicle
4.88 5.13e-03 GO:0044433 cytoplasmic vesicle part
6.66 1.15e-02 GO:0030136 clathrin-coated vesicle
7.94 1.43e-02 GO:0030662 coated vesicle membrane
5.64 3.24e-02 GO:0030425 dendrite
5.44 4.04e-02 GO:0030135 coated vesicle

Gene overrepresentation in function category:

enrichment   p-value GO term description
28.96 1.16e-03 GO:0005184 neuropeptide hormone activity
16.18 1.65e-03 GO:0005231 excitatory extracellular ligand-gated ion channel activity
9.22 5.73e-03 GO:0005179 hormone activity
10.57 1.32e-02 GO:0005230 extracellular ligand-gated ion channel activity
4.00 2.46e-02 GO:0005216 ion channel activity
3.94 2.79e-02 GO:0022838 substrate-specific channel activity
3.16 2.84e-02 GO:0005509 calcium ion binding
3.82 3.56e-02 GO:0015267 channel activity
3.81 3.63e-02 GO:0022803 passive transmembrane transporter activity
4.62 4.21e-02 GO:0005261 cation channel activity