Motif ID: RUNX1..3.p2

Z-value: 6.335


Transcription factors associated with RUNX1..3.p2:

Gene SymbolEntrez IDGene Name
RUNX1 861 runt-related transcription factor 1
RUNX2 860 runt-related transcription factor 2
RUNX3 864 runt-related transcription factor 3



Activity profile for motif RUNX1..3.p2.

activity profile for motif RUNX1..3.p2


Sorted Z-values histogram for motif RUNX1..3.p2

Sorted Z-values for motif RUNX1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RUNX1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_25164061 18.391 NM_001031680
RUNX3
runt-related transcription factor 3
chr1_-_114215768 16.485 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr16_+_29582069 14.720 NM_003123
SPN
sialophorin
chr9_-_129580732 12.983 NM_170600
SH2D3C
SH2 domain containing 3C
chr16_+_29582065 11.592 SPN
sialophorin
chr1_+_204797516 11.200 RASSF5
Ras association (RalGDS/AF-6) domain family member 5
chrX_-_30505804 10.697 NM_025159
CXorf21
chromosome X open reading frame 21
chr21_-_35343331 10.679 RUNX1
runt-related transcription factor 1
chr2_-_158008763 10.241 NM_004288
CYTIP
cytohesin 1 interacting protein
chr14_+_92188329 9.642 RIN3
Ras and Rab interactor 3
chr21_-_35343456 9.403 NM_001754
RUNX1
runt-related transcription factor 1
chr21_-_35343500 9.296 RUNX1
runt-related transcription factor 1
chr12_+_45896511 9.190 FAM113B
family with sequence similarity 113, member B
chr4_-_1185144 9.144 LOC100130872
hypothetical LOC100130872
chr21_-_35343065 9.082 RUNX1
runt-related transcription factor 1
chr6_-_41276901 8.794 NM_024807
TREML2
triggering receptor expressed on myeloid cells-like 2
chr9_-_122728173 8.793 TRAF1
TNF receptor-associated factor 1
chr21_-_35343428 8.762 RUNX1
runt-related transcription factor 1
chr12_-_101396459 8.713 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr21_-_35343448 8.649 RUNX1
runt-related transcription factor 1
chr1_+_190811479 8.426 NM_002922
RGS1
regulator of G-protein signaling 1
chr1_+_207995999 8.272 NM_025228
TRAF3IP3
TRAF3 interacting protein 3
chr1_+_204797214 8.007 RASSF5
Ras association (RalGDS/AF-6) domain family member 5
chr1_-_205012348 7.704 NM_000572
IL10
interleukin 10
chr11_-_66961709 7.575 NM_005608
PTPRCAP
protein tyrosine phosphatase, receptor type, C-associated protein
chr22_+_38627129 7.495 GRAP2
GRB2-related adaptor protein 2
chr5_-_88155360 7.465 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr22_+_38627031 7.403 NM_004810
GRAP2
GRB2-related adaptor protein 2
chr8_-_21827057 7.365 NM_003974
DOK2
docking protein 2, 56kDa
chr1_+_202000906 7.350 NM_001136190
NM_017773
LAX1

lymphocyte transmembrane adaptor 1

chr19_-_40925151 7.349 NM_024660
TMEM149
transmembrane protein 149
chr16_+_28413421 7.192 NM_018690
APOBR
apolipoprotein B receptor
chr3_+_99733432 7.120 NM_005290
GPR15
G protein-coupled receptor 15
chr6_-_11490487 7.045 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr16_+_23754822 6.804 PRKCB
protein kinase C, beta
chr16_+_23754772 6.753 NM_002738
NM_212535
PRKCB

protein kinase C, beta

chr14_+_99601517 6.688 EVL
Enah/Vasp-like
chr14_+_99601498 6.651 NM_016337
EVL
Enah/Vasp-like
chr14_+_75058518 6.516 NM_006399
BATF
basic leucine zipper transcription factor, ATF-like
chr17_-_71352090 6.413 UNC13D
unc-13 homolog D (C. elegans)
chr16_+_29581783 6.393 NM_001030288
SPN
sialophorin
chr1_+_196874867 6.369 PTPRC
protein tyrosine phosphatase, receptor type, C
chr17_-_31441390 6.285 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chr17_-_71352017 6.252 UNC13D
unc-13 homolog D (C. elegans)
chr14_+_75058591 6.208 BATF
basic leucine zipper transcription factor, ATF-like
chr16_+_23754997 6.069 PRKCB
protein kinase C, beta
chr19_+_17923110 6.011 NM_002248
KCNN1
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
chr11_+_46339691 5.965 NM_001105540
DGKZ
diacylglycerol kinase, zeta
chr1_-_205161821 5.961 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr11_+_63864263 5.841 NM_032251
CCDC88B
coiled-coil domain containing 88B
chr15_-_75259714 5.774 PEAK1
NKF3 kinase family member
chr2_-_175170674 5.758 WIPF1
WAS/WASL interacting protein family, member 1
chr12_+_25096472 5.721 NM_006152
LRMP
lymphoid-restricted membrane protein
chr4_-_10295412 5.671 NM_052964
CLNK
cytokine-dependent hematopoietic cell linker
chr6_+_31648071 5.605 NM_000595
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr8_-_102872354 5.601 NCALD
neurocalcin delta
chr14_+_92188546 5.489 RIN3
Ras and Rab interactor 3
chr4_+_76700281 5.435 NM_178497
C4orf26
chromosome 4 open reading frame 26
chr1_+_196874839 5.357 PTPRC
protein tyrosine phosphatase, receptor type, C
chr8_-_102872372 5.329 NCALD
neurocalcin delta
chr6_+_31651319 5.283 NM_000594
TNF
tumor necrosis factor
chr19_-_55560686 5.275 NM_004851
NAPSA
napsin A aspartic peptidase
chr1_-_159306037 5.230 ARHGAP30
Rho GTPase activating protein 30
chr1_+_196874759 5.193 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr13_-_45654296 5.122 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr6_+_31647854 5.114 NM_001159740
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr7_+_45033757 5.085 NM_001029835
CCM2
cerebral cavernous malformation 2
chr17_+_71292535 5.082


chr12_+_25096755 5.054 LRMP
lymphoid-restricted membrane protein
chr1_+_32489426 5.049 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr10_+_70517863 5.009 SRGN
serglycin
chr1_+_26744929 4.970 NM_001006665
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr3_+_142587973 4.965


chr5_+_140871107 4.958


chrX_-_70755023 4.939 NM_001142797
NM_001504
CXCR3

chemokine (C-X-C motif) receptor 3

chr10_+_70517823 4.878 NM_002727
SRGN
serglycin
chrX_+_48427137 4.818 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr11_-_58099884 4.752 NM_004811
LPXN
leupaxin
chr1_+_26744893 4.731 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr13_-_45654292 4.709 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chrX_+_48427103 4.704 NM_000377
WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr5_+_156628929 4.624 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr16_-_66590856 4.601 NM_022355
DPEP2
dipeptidase 2
chr2_+_102401580 4.595 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr17_+_71292437 4.554 UNK
unkempt homolog (Drosophila)
chr19_-_47328399 4.469 NM_002698
POU2F2
POU class 2 homeobox 2
chr7_+_149761674 4.406 LOC285972
hypothetical LOC285972
chr5_+_140870881 4.399


chr1_-_157313179 4.389 NM_004833
AIM2
absent in melanoma 2
chr16_+_23754860 4.386 PRKCB
protein kinase C, beta
chr6_+_37511383 4.351


chr1_-_155788775 4.321 NM_001195388
NM_031281
FCRL5

Fc receptor-like 5

chr19_-_60458915 4.317 PPP6R1
protein phosphatase 6, regulatory subunit 1
chr11_-_5232480 4.288 NM_000184
HBG1
HBG2
hemoglobin, gamma A
hemoglobin, gamma G
chr4_-_38482805 4.203 NM_003263
TLR1
toll-like receptor 1
chr8_-_102872614 4.201 NM_032041
NCALD
neurocalcin delta
chrX_+_78087484 4.195 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr11_-_56761250 4.119 NM_005161
APLNR
apelin receptor
chr6_-_31853027 4.086 NM_025258
C6orf27
chromosome 6 open reading frame 27
chr16_+_51690564 4.075 CHD9
chromodomain helicase DNA binding protein 9
chr16_+_28797309 4.033 NM_004320
NM_173201
ATP2A1

ATPase, Ca++ transporting, cardiac muscle, fast twitch 1

chrX_+_9391314 4.029 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr20_+_54420574 4.025 NM_001164116
NM_001164114
NM_001164115
NM_020356
CASS4



Cas scaffolding protein family member 4



chr18_+_70317802 3.994 NM_001168499
CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr1_+_204797120 3.956 RASSF5
Ras association (RalGDS/AF-6) domain family member 5
chrX_-_48655978 3.956 PIM2
pim-2 oncogene
chr1_+_204797079 3.940 NM_182665
RASSF5
Ras association (RalGDS/AF-6) domain family member 5
chr7_-_92686773 3.924 NM_198151
HEPACAM2
HEPACAM family member 2
chr1_+_234624266 3.915 NM_145861
EDARADD
EDAR-associated death domain
chr19_+_60109319 3.908 NM_001145457
NM_001145458
NM_004829
NCR1


natural cytotoxicity triggering receptor 1


chr19_-_18058632 3.838 NM_005535
NM_153701
IL12RB1

interleukin 12 receptor, beta 1

chr1_-_159306210 3.829 ARHGAP30
Rho GTPase activating protein 30
chr19_+_16115454 3.811 HSH2D
hematopoietic SH2 domain containing
chr6_+_52159143 3.803 NM_002190
IL17A
interleukin 17A
chr19_-_48976852 3.799 KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr1_-_159306273 3.774 ARHGAP30
Rho GTPase activating protein 30
chr1_+_149395728 3.760 NM_024575
TNFAIP8L2
tumor necrosis factor, alpha-induced protein 8-like 2
chr3_+_47004457 3.692 NBEAL2
neurobeachin-like 2
chr19_+_17495109 3.688 NM_001098524
NM_173544
FAM129C

family with sequence similarity 129, member C

chr19_+_2240996 3.673


chr5_+_125723686 3.616 NM_001146319
GRAMD3
GRAM domain containing 3
chr14_-_93493519 3.614 NM_016150
ASB2
ankyrin repeat and SOCS box containing 2
chr10_-_11614279 3.596 NM_001080491
USP6NL
USP6 N-terminal like
chr4_+_38740246 3.592 NM_015990
NM_199039
KLHL5

kelch-like 5 (Drosophila)

chrX_-_39921525 3.566 NM_001123383
NM_001123384
BCOR

BCL6 corepressor

chrX_-_135690770 3.490 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr9_-_99740243 3.486 NM_197978
HEMGN
hemogen
chr8_-_101384633 3.482 NM_015435
RNF19A
ring finger protein 19A
chr6_-_36412562 3.433 NM_001010903
C6orf222
chromosome 6 open reading frame 222
chrX_-_135690699 3.430 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr4_-_71751205 3.418 NM_144646
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr4_-_71751070 3.415 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr4_-_38534802 3.399 NM_006068
TLR6
toll-like receptor 6
chr17_-_71352182 3.378 NM_199242
UNC13D
unc-13 homolog D (C. elegans)
chr17_-_59363352 3.369 NM_000626
NM_001039933
NM_021602
CD79B


CD79b molecule, immunoglobulin-associated beta


chr10_-_6144119 3.365 NM_000417
IL2RA
interleukin 2 receptor, alpha
chr6_-_149847809 3.318 NM_207360
ZC3H12D
zinc finger CCCH-type containing 12D
chr17_+_69974116 3.306 NM_007261
CD300A
CD300a molecule
chr14_-_104602784 3.246 NM_013345
GPR132
G protein-coupled receptor 132
chr18_+_19826734 3.242 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr6_-_33028790 3.236 NM_006120
HLA-DMA
major histocompatibility complex, class II, DM alpha
chr11_+_60495690 3.224 NM_006725
CD6
CD6 molecule
chr5_+_176807931 3.223 NM_001174102
PRR7
proline rich 7 (synaptic)
chr17_+_43165608 3.213 NM_013351
TBX21
T-box 21
chr16_+_48857962 3.204 ADCY7
adenylate cyclase 7
chr20_-_1548589 3.155 NM_001083910
NM_001135844
NM_006065
SIRPB1


signal-regulatory protein beta 1


chr6_-_119137923 3.115 NM_001178035
C6orf204
chromosome 6 open reading frame 204
chr1_-_159306327 3.111 ARHGAP30
Rho GTPase activating protein 30
chr6_-_32892705 3.107 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr15_+_64481270 3.107 MAP2K1
mitogen-activated protein kinase kinase 1
chr16_+_27346079 3.097 NM_021798
IL21R
interleukin 21 receptor
chr2_+_201806410 3.071 NM_001080124
NM_001228
NM_033355
NM_033358
CASP8



caspase 8, apoptosis-related cysteine peptidase



chr17_-_77512346 3.041 NM_178493
NOTUM
notum pectinacetylesterase homolog (Drosophila)
chr20_-_48741481 3.020


chr5_+_176717553 3.013


chr9_-_122728993 2.955 NM_005658
TRAF1
TNF receptor-associated factor 1
chr18_+_59726183 2.949 SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr5_+_75734759 2.947 NM_006633
IQGAP2
IQ motif containing GTPase activating protein 2
chr1_-_159306369 2.944 NM_001025598
NM_181720
ARHGAP30

Rho GTPase activating protein 30

chr4_-_113656762 2.940 NM_024019
NEUROG2
neurogenin 2
chr6_-_68655708 2.934


chr17_-_26672757 2.933 NM_001003927
NM_014210
EVI2A

ecotropic viral integration site 2A

chr14_-_104602809 2.930 GPR132
G protein-coupled receptor 132
chrX_-_77801480 2.888 NM_152694
ZCCHC5
zinc finger, CCHC domain containing 5
chr5_-_140875591 2.885 DIAPH1
diaphanous homolog 1 (Drosophila)
chr14_-_101617680 2.864 HSP90AA1
heat shock protein 90kDa alpha (cytosolic), class A member 1
chr19_-_45947667 2.848 NM_198476
C19orf54
chromosome 19 open reading frame 54
chr19_-_4131778 2.835 SIRT6
sirtuin 6
chr22_+_23333610 2.833 NM_001032365
GGT1
gamma-glutamyltransferase 1
chr2_+_169367345 2.810 NM_001039724
NM_001171632
NM_052946
NOSTRIN


nitric oxide synthase trafficker


chr20_+_36365965 2.793 NM_001725
BPI
bactericidal/permeability-increasing protein
chr17_+_71292275 2.776 NM_001080419
UNK
unkempt homolog (Drosophila)
chr1_+_40631603 2.772 NM_001198979
SMAP2
small ArfGAP2
chr4_+_39874921 2.763 NM_004310
RHOH
ras homolog gene family, member H
chr2_-_88946767 2.737


chr2_+_68445936 2.719 PLEK
pleckstrin
chr16_+_31105579 2.714


chr12_+_9713472 2.710 NM_001197318
NM_013269
NM_001004419
NM_001197317
NM_001197319
CLEC2D




C-type lectin domain family 2, member D




chr5_+_176717449 2.704 NM_006480
RGS14
regulator of G-protein signaling 14
chr11_-_31782169 2.659 PAX6
paired box 6
chr16_-_66075216 2.657 NM_001138
AGRP
agouti related protein homolog (mouse)
chrX_-_135691168 2.627 NM_004840
ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr6_-_35804337 2.615 NM_001145775
FKBP5
FK506 binding protein 5
chr5_-_39238818 2.591 FYB
FYN binding protein
chr1_+_156490550 2.567 NM_001763
CD1A
CD1a molecule
chr6_-_32121784 2.563 NM_032470
TNXB
tenascin XB
chr1_-_92724181 2.560 NM_001127216
GFI1
growth factor independent 1 transcription repressor
chr13_-_27572646 2.511 NM_004119
FLT3
fms-related tyrosine kinase 3
chr6_-_149847718 2.487 ZC3H12D
zinc finger CCCH-type containing 12D
chr6_+_30212488 2.480 NM_138700
TRIM40
tripartite motif containing 40
chr22_+_35586950 2.477 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr17_+_77910411 2.454 NM_207459
TEX19
testis expressed 19
chr16_+_29982941 2.449 ALDOA
aldolase A, fructose-bisphosphate
chr17_+_72827968 2.436 SEPT9
septin 9
chrX_-_78509662 2.429 NM_001171581
NM_004867
ITM2A

integral membrane protein 2A

chr8_-_127032577 2.423 LOC100130231
similar to hCG1814455
chr19_-_14646626 2.402 NM_032571
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr8_+_144173674 2.390 LY6E
lymphocyte antigen 6 complex, locus E
chr16_+_29983029 2.377 NM_184043
ALDOA
aldolase A, fructose-bisphosphate
chr16_+_31273969 2.370 NM_000887
ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.65 8.34e-08 GO:0002376 immune system process
1.93 2.24e-05 GO:0001775 cell activation
1.72 3.82e-05 GO:0006955 immune response
2.31 1.54e-03 GO:0046649 lymphocyte activation
1.17 1.65e-03 GO:0050896 response to stimulus
2.05 1.21e-02 GO:0045321 leukocyte activation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.21 7.50e-04 GO:0071944 cell periphery
1.21 1.17e-03 GO:0005886 plasma membrane
6.40 1.12e-02 GO:0005833 hemoglobin complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.12 6.97e-04 GO:0003823 antigen binding
1.33 1.72e-03 GO:0004871 signal transducer activity
1.33 1.72e-03 GO:0060089 molecular transducer activity
1.35 4.12e-03 GO:0004872 receptor activity