Motif ID: POU6F1.p2

Z-value: 1.971


Transcription factors associated with POU6F1.p2:

Gene SymbolEntrez IDGene Name
POU6F1 5463 POU class 6 homeobox 1



Activity profile for motif POU6F1.p2.

activity profile for motif POU6F1.p2


Sorted Z-values histogram for motif POU6F1.p2

Sorted Z-values for motif POU6F1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU6F1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_65299157 3.666 NM_138737
HEPH
hephaestin
chr4_-_145281237 3.080 NM_002099
GYPA
glycophorin A (MNS blood group)
chr6_+_105511615 3.071 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr8_-_13018123 2.642 NM_001164271
DLC1
deleted in liver cancer 1
chr1_+_58899 2.151 NM_001005484
OR4F4
OR4F5
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 5
chr10_+_94584449 2.116 NM_001013848
EXOC6
exocyst complex component 6
chr4_-_145159889 2.084 NM_002100
GYPB
glycophorin B (MNS blood group)
chr16_+_33169015 1.978 NM_016212
TP53TG3
TP53 target 3
chr16_-_32595553 1.946 NM_016212
TP53TG3
TP53 target 3
chr16_+_33112480 1.901 NM_016212
TP53TG3
TP53 target 3
chr7_-_92693716 1.870 NM_001039372
HEPACAM2
HEPACAM family member 2
chr5_+_139869819 1.857


chr10_+_4995685 1.839 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr15_-_100280784 1.793 NM_001004195
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr14_-_60022487 1.774 NM_174978
C14orf39
chromosome 14 open reading frame 39
chr22_+_38652555 1.752 GRAP2
GRB2-related adaptor protein 2
chr1_+_166516901 1.714 NM_005149
TBX19
T-box 19
chr10_+_4995453 1.713 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr19_-_54350457 1.675 NM_002152
HRC
histidine rich calcium binding protein
chr1_+_158603480 1.664 NM_005598
NHLH1
nescient helix loop helix 1
chr6_+_7524691 1.629 DSP
desmoplakin
chrX_-_55074125 1.617 NM_000032
NM_001037967
NM_001037968
ALAS2


aminolevulinate, delta-, synthase 2


chr17_-_36232366 1.608 NM_000421
KRT10
keratin 10
chrX_+_65299352 1.595 HEPH
hephaestin
chr4_+_71806538 1.582 NM_001037442
NM_014961
RUFY3

RUN and FYVE domain containing 3

chr1_+_194887630 1.562 NM_000186
NM_001014975
CFH

complement factor H

chr19_+_61624 1.487 NM_001005240
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr1_-_191422346 1.475 NM_003783
B3GALT2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr1_+_109057078 1.423 NM_001144937
FNDC7
fibronectin type III domain containing 7
chr10_-_5035967 1.359 NM_001135241
AKR1C1
AKR1C2
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr10_+_4995597 1.330 AKR1C1
AKR1C3
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr17_-_64462976 1.322 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr5_+_140509803 1.266 NM_018939
PCDHB6
protocadherin beta 6
chr7_+_128136347 1.252 FAM71F1
family with sequence similarity 71, member F1
chr13_-_43908991 1.231 TSC22D1
TSC22 domain family, member 1
chr13_-_43908994 1.224 TSC22D1
TSC22 domain family, member 1
chr3_+_129682434 1.205


chr6_-_49942147 1.204 NM_001131
NM_170609
CRISP1

cysteine-rich secretory protein 1

chr10_-_30958631 1.198 NM_183058
LYZL2
lysozyme-like 2
chr13_-_43908985 1.195 TSC22D1
TSC22 domain family, member 1
chr7_+_91762227 1.165


chr13_-_43908995 1.161 TSC22D1
TSC22 domain family, member 1
chr11_+_5466490 1.155 NM_001005163
OR52D1
olfactory receptor, family 52, subfamily D, member 1
chr13_-_43908937 1.056 TSC22D1
TSC22 domain family, member 1
chr6_+_47857733 1.046 NM_181744
OPN5
opsin 5
chr7_-_107667728 1.036 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr13_-_43908972 1.034 NM_006022
TSC22D1
TSC22 domain family, member 1
chr22_+_21116283 1.032


chr2_-_158439868 1.027 NM_001105
ACVR1
activin A receptor, type I
chr3_-_191650291 0.987 NM_207316
TMEM207
transmembrane protein 207
chr4_-_140280031 0.972 NM_201999
ELF2
E74-like factor 2 (ets domain transcription factor)
chr2_+_128119908 0.957 NM_001161415
NM_001161416
NM_001161417
NM_005291
GPR17



G protein-coupled receptor 17



chrX_-_153698930 0.947 HMGN1P37
high-mobility group nucleosome binding domain 1 pseudogene 37
chr7_-_99864220 0.945 NM_017984
ZCWPW1
zinc finger, CW type with PWWP domain 1
chr17_-_36276987 0.903 NM_000223
KRT12
keratin 12
chr17_+_20712337 0.897


chr11_-_11331411 0.890 CSNK2A1P
casein kinase 2, alpha 1 polypeptide pseudogene
chr2_-_169596078 0.889 NM_003742
ABCB11
ATP-binding cassette, sub-family B (MDR/TAP), member 11
chr4_-_145046109 0.874 NM_002102
NM_198682
GYPE

glycophorin E (MNS blood group)

chr18_-_55136673 0.850 NM_181654
CPLX4
complexin 4
chr4_-_45820686 0.848 NM_173536
GABRG1
gamma-aminobutyric acid (GABA) A receptor, gamma 1
chr3_-_121117647 0.841 GSK3B
glycogen synthase kinase 3 beta
chrX_-_107569256 0.834 NM_001847
COL4A6
collagen, type IV, alpha 6
chrX_+_67830204 0.828 NM_001142504
STARD8
StAR-related lipid transfer (START) domain containing 8
chr1_-_93030538 0.827 NM_005665
EVI5
ecotropic viral integration site 5
chr1_-_120189301 0.815 NM_001047980
NBPF7
neuroblastoma breakpoint family, member 7
chr1_+_559618 0.791


chr17_-_46479127 0.777 SPAG9
sperm associated antigen 9
chr1_+_234748187 0.748 NM_201545
LGALS8
lectin, galactoside-binding, soluble, 8
chr7_+_99864348 0.747 NM_001194990
NM_001194991
NM_001194992
MEPCE


methylphosphate capping enzyme


chr5_+_139485703 0.744 NM_001007189
C5orf53
chromosome 5 open reading frame 53
chr12_+_108310906 0.725 NM_001101421
MYO1H
myosin IH
chr7_-_100262971 0.722 NM_004444
EPHB4
EPH receptor B4
chr12_-_110410730 0.719 ATXN2
ataxin 2
chr7_+_93373755 0.717 NM_021955
GNGT1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr22_-_34566210 0.706 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr18_-_12646730 0.699 NM_001128627
SPIRE1
spire homolog 1 (Drosophila)
chr3_-_18455207 0.682 NM_001131010
SATB1
SATB homeobox 1
chr22_-_34566276 0.677 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr2_-_1905508 0.658 MYT1L
myelin transcription factor 1-like
chr2_+_113532685 0.655 NM_173170
IL1F5
interleukin 1 family, member 5 (delta)
chr11_+_69176391 0.653 CCND1
cyclin D1
chrX_-_33139349 0.651 NM_004006
DMD
dystrophin
chr18_+_59295123 0.647 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr6_-_150099352 0.644 NUP43
nucleoporin 43kDa
chr11_-_123758448 0.642 NM_001005468
OR8B2
olfactory receptor, family 8, subfamily B, member 2
chr7_+_106897737 0.641 NM_005295
GPR22
G protein-coupled receptor 22
chr10_+_29617995 0.641 NM_032517
LYZL1
lysozyme-like 1
chr22_-_34566367 0.635 NM_001031695
NM_001082576
NM_001082577
NM_014309
RBFOX2



RNA binding protein, fox-1 homolog (C. elegans) 2



chr12_-_69434330 0.629 PTPRR
protein tyrosine phosphatase, receptor type, R
chr7_-_135083906 0.613 NM_205855
FAM180A
family with sequence similarity 180, member A
chr3_+_99350859 0.605 NM_001005514
OR5H14
olfactory receptor, family 5, subfamily H, member 14
chr18_+_27281729 0.591 NM_001944
DSG3
desmoglein 3
chr1_+_149299307 0.586 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr5_+_140583098 0.584 NM_018934
PCDHB14
protocadherin beta 14
chr8_-_91164100 0.576 NM_004929
CALB1
calbindin 1, 28kDa
chr12_-_8110268 0.575 C3AR1
complement component 3a receptor 1
chr22_-_21193504 0.566 NM_080764
ZNF280B
zinc finger protein 280B
chr6_+_45404031 0.566 NM_001015051
NM_001024630
RUNX2

runt-related transcription factor 2

chr15_+_65205107 0.564 NM_001145102
SMAD3
SMAD family member 3
chr18_+_27210737 0.552 NM_001134453
NM_177986
DSG4

desmoglein 4

chr1_-_178100204 0.549


chr12_-_88573949 0.540 NM_001001323
NM_001682
ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

chr4_-_164614335 0.535 NM_032136
TKTL2
transketolase-like 2
chr22_+_21006814 0.534


chr4_+_35962038 0.532 NM_001170700
DTHD1
death domain containing 1
chr7_+_138469029 0.530 NM_001144920
NM_001144923
NM_024926
TTC26


tetratricopeptide repeat domain 26


chr2_+_166034402 0.530 NM_001172173
CSRNP3
cysteine-serine-rich nuclear protein 3
chr12_+_54172413 0.529 NM_001005519
OR6C68
olfactory receptor, family 6, subfamily C, member 68
chr6_-_123999640 0.528 NM_006073
TRDN
triadin
chr8_-_49996353 0.526 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr11_-_27637771 0.519 NM_001143816
NM_170735
BDNF

brain-derived neurotrophic factor

chr11_-_16454493 0.518 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chr1_-_149611768 0.516 NM_003944
SELENBP1
selenium binding protein 1
chr6_+_29187565 0.513 NM_001005216
OR2J3
olfactory receptor, family 2, subfamily J, member 3
chr3_+_46894239 0.506 NM_000316
PTH1R
parathyroid hormone 1 receptor
chr2_-_225073357 0.501 CUL3
cullin 3
chr7_+_99864349 0.499 MEPCE
methylphosphate capping enzyme
chr1_+_74473672 0.488 NM_015978
TNNI3K
TNNI3 interacting kinase
chr6_-_47385604 0.482 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr11_-_57173823 0.479 NM_145008
YPEL4
yippee-like 4 (Drosophila)
chrX_+_86659370 0.476 NM_019117
NM_057162
KLHL4

kelch-like 4 (Drosophila)

chr7_+_143043871 0.462 NM_001130026
FAM115C
family with sequence similarity 115, member C
chr11_-_59390518 0.458 NM_001062
TCN1
transcobalamin I (vitamin B12 binding protein, R binder family)
chr7_+_99865189 0.452 NM_019606
MEPCE
methylphosphate capping enzyme
chr5_-_156322784 0.447 NM_001146726
NM_138379
TIMD4

T-cell immunoglobulin and mucin domain containing 4

chr20_+_56919233 0.441 GNAS
GNAS complex locus
chr2_+_169367345 0.440 NM_001039724
NM_001171632
NM_052946
NOSTRIN


nitric oxide synthase trafficker


chr6_-_50045296 0.438 NM_001037729
DEFB113
defensin, beta 113
chr7_+_113853790 0.433 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr5_-_145232723 0.433 NM_001080516
GRXCR2
glutaredoxin, cysteine rich 2
chr5_-_39238818 0.432 FYB
FYN binding protein
chr3_+_143858428 0.432 NM_001172312
PLS1
plastin 1
chr17_-_64752550 0.429 NM_080282
ABCA10
ATP-binding cassette, sub-family A (ABC1), member 10
chr14_-_56342097 0.425 NM_172337
OTX2
orthodenticle homeobox 2
chr2_-_157890400 0.423 NM_020711
ERMN
ermin, ERM-like protein
chr2_+_33213111 0.422 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chrX_-_52752935 0.422 NM_003147
NM_175698
NM_001164417
SSX2

SSX2B
synovial sarcoma, X breakpoint 2

synovial sarcoma, X breakpoint 2B
chr6_-_2696152 0.421 NM_001012418
MYLK4
myosin light chain kinase family, member 4
chr7_-_112514990 0.421 GPR85
G protein-coupled receptor 85
chr10_+_69539255 0.413 NM_032578
MYPN
myopalladin
chr17_-_57023322 0.411 NM_199290
NACA2
nascent polypeptide-associated complex alpha subunit 2
chr17_-_10313600 0.410 NM_017533
MYH4
myosin, heavy chain 4, skeletal muscle
chr6_+_12825818 0.409 NM_030948
PHACTR1
phosphatase and actin regulator 1
chr13_+_112746908 0.407 MCF2L
MCF.2 cell line derived transforming sequence-like
chr13_+_108079570 0.407 NM_001198950
MYO16
myosin XVI
chr7_+_120490054 0.407 C7orf58
chromosome 7 open reading frame 58
chr6_-_155818728 0.403 NM_015718
NOX3
NADPH oxidase 3
chrX_-_13744933 0.401 GPM6B
glycoprotein M6B
chr12_+_16391342 0.395 NM_145792
MGST1
microsomal glutathione S-transferase 1
chr12_-_7739591 0.391 NM_020634
GDF3
growth differentiation factor 3
chr8_-_38324809 0.388 WHSC1L1
Wolf-Hirschhorn syndrome candidate 1-like 1
chr2_+_178893216 0.386 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr21_-_35153664 0.382 RUNX1
runt-related transcription factor 1
chr6_-_136888771 0.381 NM_001198608
NM_001198609
NM_001198611
MAP7


microtubule-associated protein 7


chr7_+_156677777 0.379


chr3_-_110517929 0.379 NM_138815
DPPA2
developmental pluripotency associated 2
chr5_-_27074407 0.373 NM_016279
CDH9
cadherin 9, type 2 (T1-cadherin)
chr1_+_151270301 0.373 NM_003125
SPRR1B
small proline-rich protein 1B
chr3_-_197726587 0.371 NM_001077657
C3orf43
chromosome 3 open reading frame 43
chr8_-_59575249 0.368 NM_000780
CYP7A1
cytochrome P450, family 7, subfamily A, polypeptide 1
chr7_-_38279757 0.366 NM_001003799
NM_001003806
TARP

TRGV9
TCR gamma alternate reading frame protein

T cell receptor gamma variable 9
chrX_+_36163971 0.362 NM_001098843
CXorf30
chromosome X open reading frame 30
chr1_+_149299490 0.362 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr14_-_100420936 0.361 NM_001134888
RTL1
retrotransposon-like 1
chr7_+_134114912 0.359 CALD1
caldesmon 1
chr7_-_25234582 0.359 NM_022150
NPVF
neuropeptide VF precursor
chr3_-_152641248 0.347 NM_001178145
NM_001178146
IGSF10

immunoglobulin superfamily, member 10

chr21_-_35343428 0.345 RUNX1
runt-related transcription factor 1
chr1_+_46151845 0.341 MAST2
microtubule associated serine/threonine kinase 2
chr2_-_200033445 0.339 SATB2
SATB homeobox 2
chr6_-_47385470 0.336 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr9_-_94206648 0.333 NM_014057
NM_033014
OGN

osteoglycin

chr1_-_41399632 0.328 NM_001031694
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr7_+_129771865 0.326 NM_001127441
NM_001127442
NM_080385
CPA5


carboxypeptidase A5


chr5_-_145503190 0.325 LARS
leucyl-tRNA synthetase
chr16_-_69392561 0.320 NM_018052
VAC14
Vac14 homolog (S. cerevisiae)
chr15_-_48626193 0.318 NM_203494
USP50
ubiquitin specific peptidase 50
chr3_-_139960874 0.317 NM_006219
PIK3CB
phosphoinositide-3-kinase, catalytic, beta polypeptide
chr1_-_159543847 0.316 MPZ
myelin protein zero
chr17_-_36192311 0.314 NM_181537
KRT27
keratin 27
chr12_+_98565663 0.311 NM_153364
FAM71C
family with sequence similarity 71, member C
chr22_+_21065134 0.311 LOC100290481
immunoglobulin lambda light chain-like
chr1_+_556968 0.309


chr2_+_96672200 0.307 NM_001113382
FER1L5
fer-1-like 5 (C. elegans)
chr9_+_80134302 0.307 PSAT1
phosphoserine aminotransferase 1
chr12_-_69434650 0.306 PTPRR
protein tyrosine phosphatase, receptor type, R
chr17_+_3326045 0.306 NM_000049
ASPA
aspartoacylase
chr1_+_61642287 0.305 NFIA
nuclear factor I/A
chr11_+_123398929 0.304 NM_001001953
OR10G9
olfactory receptor, family 10, subfamily G, member 9
chrX_-_102828238 0.303 NM_001142418
NM_001142423
NM_001142424
NM_001142425
NM_001142426
NM_001142429
NM_001142430
NM_012286
MORF4L2







mortality factor 4 like 2







chr11_-_123772456 0.303 NM_001005467
OR8B3
olfactory receptor, family 8, subfamily B, member 3
chr20_+_86121 0.299 NM_139074
DEFB127
defensin, beta 127
chr7_-_135263737 0.298 MTPN
LUZP6
myotrophin
leucine zipper protein 6
chr18_+_606671 0.293 NM_199167
CLUL1
clusterin-like 1 (retinal)
chr6_+_88239343 0.292 NM_001168398
NM_006416
SLC35A1

solute carrier family 35 (CMP-sialic acid transporter), member A1

chr16_-_69392385 0.288 VAC14
Vac14 homolog (S. cerevisiae)
chr12_-_69434598 0.281 NM_130846
PTPRR
protein tyrosine phosphatase, receptor type, R
chr12_+_52126131 0.280 PRR13
proline rich 13
chr21_-_35343456 0.279 NM_001754
RUNX1
runt-related transcription factor 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.51 1.35e-10 GO:0007606 sensory perception of chemical stimulus
3.58 8.58e-10 GO:0007608 sensory perception of smell
2.42 1.43e-06 GO:0007600 sensory perception
1.39 3.46e-05 GO:0032501 multicellular organismal process
1.79 1.30e-04 GO:0003008 system process
1.88 2.28e-04 GO:0050877 neurological system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.46 4.42e-06 GO:0071944 cell periphery
1.44 1.41e-05 GO:0005886 plasma membrane
4.02 2.14e-03 GO:0030016 myofibril
3.79 4.22e-03 GO:0043292 contractile fiber
1.52 7.31e-03 GO:0005576 extracellular region
3.83 7.45e-03 GO:0044449 contractile fiber part
1.21 4.97e-02 GO:0044425 membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.71 8.25e-11 GO:0004930 G-protein coupled receptor activity
3.66 1.89e-10 GO:0004984 olfactory receptor activity
2.13 7.25e-08 GO:0004888 transmembrane receptor activity
1.93 1.05e-07 GO:0004872 receptor activity
1.74 4.15e-06 GO:0004871 signal transducer activity
1.74 4.15e-06 GO:0060089 molecular transducer activity
2.64 3.32e-03 GO:0003779 actin binding
22.21 3.75e-03 GO:0004558 alpha-glucosidase activity
24.99 3.45e-02 GO:0047023 androsterone dehydrogenase activity
24.99 3.45e-02 GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity