Motif ID: HAND1,2.p2

Z-value: 3.722


Transcription factors associated with HAND1,2.p2:

Gene SymbolEntrez IDGene Name
HAND1 9421 heart and neural crest derivatives expressed 1
HAND2 9464 heart and neural crest derivatives expressed 2



Activity profile for motif HAND1,2.p2.

activity profile for motif HAND1,2.p2


Sorted Z-values histogram for motif HAND1,2.p2

Sorted Z-values for motif HAND1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HAND1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_-_45339605 6.912 NM_182493
MYLK3
myosin light chain kinase 3
chr11_+_66927976 6.522 NM_198517
TBC1D10C
TBC1 domain family, member 10C
chr16_-_28515868 5.957 NM_001054
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr22_+_23329113 5.837 NM_001032364
NM_005265
GGT1

gamma-glutamyltransferase 1

chr19_-_10074332 5.813 NM_031917
ANGPTL6
angiopoietin-like 6
chr22_+_43451600 5.086 PRR5
proline rich 5 (renal)
chr20_-_1113116 4.399 NM_018354
C20orf46
chromosome 20 open reading frame 46
chrX_-_48213508 3.836 SLC38A5
solute carrier family 38, member 5
chr17_-_37590910 3.744 NM_001524
HCRT
hypocretin (orexin) neuropeptide precursor
chr11_+_118463906 3.705 NM_001024382
HMBS
hydroxymethylbilane synthase
chr22_+_43451351 3.688 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chr19_-_12807221 3.681 NM_031429
RTBDN
retbindin
chr2_-_25328452 3.559 NM_153759
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr5_-_149772563 3.496 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr16_+_28413421 3.484 NM_018690
APOBR
apolipoprotein B receptor
chrX_-_48213545 3.359 NM_033518
SLC38A5
solute carrier family 38, member 5
chr19_+_55614006 3.330 NM_003121
SPIB
Spi-B transcription factor (Spi-1/PU.1 related)
chr15_+_42815851 3.292 NM_080745
NM_182985
TRIM69

tripartite motif containing 69

chr4_+_76700281 3.245 NM_178497
C4orf26
chromosome 4 open reading frame 26
chr19_+_41085221 3.229 NM_001007469
NM_014266
HCST

hematopoietic cell signal transducer

chr6_+_6533932 3.227 NM_004271
LY86
lymphocyte antigen 86
chr16_+_56286212 3.226 NM_032269
CCDC135
coiled-coil domain containing 135
chr19_+_40465249 3.193 NM_021175
HAMP
hepcidin antimicrobial peptide
chr4_+_22608252 3.154


chr9_-_99740243 3.133 NM_197978
HEMGN
hemogen
chr14_+_75058518 3.130 NM_006399
BATF
basic leucine zipper transcription factor, ATF-like
chr16_+_29582065 3.036 SPN
sialophorin
chr14_+_75058591 3.014 BATF
basic leucine zipper transcription factor, ATF-like
chr6_+_167445284 2.995 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr1_-_158815895 2.991 NM_001184879
NM_001184881
NM_001184882
NM_003874
CD84



CD84 molecule



chr5_-_149772528 2.990


chrX_+_49718954 2.972 NM_000084
CLCN5
chloride channel 5
chr12_+_56114724 2.934 NM_005538
INHBC
inhibin, beta C
chr2_+_218978375 2.925 CTDSP1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr19_+_40224480 2.841 HPN
hepsin
chr17_-_76897590 2.805 NM_178519
C17orf55
chromosome 17 open reading frame 55
chr1_+_205328834 2.770 NM_001017365
NM_001017366
C4BPB

complement component 4 binding protein, beta

chr11_+_2279932 2.698 TSPAN32
tetraspanin 32
chr3_+_99733432 2.648 NM_005290
GPR15
G protein-coupled receptor 15
chr21_+_41616590 2.635 FAM3B
family with sequence similarity 3, member B
chr11_+_2279812 2.561 NM_139022
TSPAN32
tetraspanin 32
chr7_-_100630912 2.546 NM_178176
MOGAT3
monoacylglycerol O-acyltransferase 3
chr1_-_158815850 2.543 CD84
CD84 molecule
chr1_-_26517342 2.539 NM_145345
UBXN11
UBX domain protein 11
chr19_-_56585603 2.522 NM_001193623
LOC147646
hypothetical protein LOC147646
chr1_+_159899528 2.499 NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001
FCGR2B




FCGR2C
Fc fragment of IgG, low affinity IIb, receptor (CD32)




Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr1_+_159943385 2.426 NM_001184866
NM_001184867
NM_001184870
NM_001184871
NM_001184872
NM_001184873
NM_032738
FCRLA






Fc receptor-like A






chr20_+_34937928 2.415 NM_080628
C20orf118
chromosome 20 open reading frame 118
chr19_-_56564068 2.414 NM_152353
CLDND2
claudin domain containing 2
chr2_-_73781974 2.412 NM_016347
NAT8B
N-acetyltransferase 8B (GCN5-related, putative, gene/pseudogene)
chr1_+_26517045 2.398 CD52
CD52 molecule
chr1_+_28134090 2.396 NM_001009568
NM_014474
SMPDL3B

sphingomyelin phosphodiesterase, acid-like 3B

chr19_+_10404110 2.391 NM_001111309
PDE4A
phosphodiesterase 4A, cAMP-specific
chr11_-_2279642 2.389 NM_001142946
C11orf21
chromosome 11 open reading frame 21
chr11_+_359723 2.335 NM_178537
B4GALNT4
beta-1,4-N-acetyl-galactosaminyl transferase 4
chr1_-_92724181 2.304 NM_001127216
GFI1
growth factor independent 1 transcription repressor
chr8_-_82769761 2.302 NM_001010893
SLC10A5
solute carrier family 10 (sodium/bile acid cotransporter family), member 5
chr11_-_63087430 2.300 NM_017878
HRASLS2
HRAS-like suppressor 2
chr19_+_3659358 2.300 TJP3
tight junction protein 3 (zona occludens 3)
chr1_+_159817752 2.268 NM_201563
FCGR2C
Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr20_-_48686832 2.214 NM_080829
FAM65C
family with sequence similarity 65, member C
chr19_+_60850765 2.162 NM_013301
CCDC106
coiled-coil domain containing 106
chr14_-_64479198 2.158 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr1_-_166149867 2.157 NM_001167749
NM_018417
ADCY10

adenylate cyclase 10 (soluble)

chr7_+_99654806 2.148 NM_024070
PVRIG
poliovirus receptor related immunoglobulin domain containing
chr6_+_88026338 2.137 ZNF292
zinc finger protein 292
chr9_+_124177421 2.118 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr5_-_149772469 2.068 NM_001025159
NM_004355
NM_001025158
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr11_+_22646229 2.050 NM_177553
GAS2
growth arrest-specific 2
chr1_-_158948176 2.009 NM_001778
CD48
CD48 molecule
chr17_+_16259812 2.000 TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr20_+_764710 1.967 NM_207121
FAM110A
family with sequence similarity 110, member A
chr1_+_26516967 1.958 NM_001803
CD52
CD52 molecule
chr2_+_218929822 1.931 NM_198559
C2orf62
chromosome 2 open reading frame 62
chr1_+_556968 1.929


chr16_-_31054321 1.910 PRSS8
protease, serine, 8
chr10_-_5035967 1.907 NM_001135241
AKR1C1
AKR1C2
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr12_+_53177806 1.897 NCKAP1L
NCK-associated protein 1-like
chr16_-_3089253 1.893 ZSCAN10
zinc finger and SCAN domain containing 10
chr22_+_23333610 1.872 NM_001032365
GGT1
gamma-glutamyltransferase 1
chr1_+_226404037 1.842 NM_020435
GJC2
gap junction protein, gamma 2, 47kDa
chr11_-_64520964 1.790 NM_138456
BATF2
basic leucine zipper transcription factor, ATF-like 2
chr12_+_53177789 1.784 NCKAP1L
NCK-associated protein 1-like
chr3_+_153499883 1.748 NM_207293
NM_207294
NM_207295
NM_207296
NM_207297
MBNL1




muscleblind-like (Drosophila)




chr1_+_205329206 1.734 NM_000716
NM_001017364
NM_001017367
C4BPB


complement component 4 binding protein, beta


chr17_-_8711701 1.725 NM_001010855
PIK3R6
phosphoinositide-3-kinase, regulatory subunit 6
chr22_+_21393107 1.694 IGLJ3
immunoglobulin lambda joining 3
chr7_-_150385912 1.692 NM_001164410
NM_004935
CDK5

cyclin-dependent kinase 5

chr11_-_5227611 1.685 NM_000559
HBG1
HBG2
hemoglobin, gamma A
hemoglobin, gamma G
chr6_-_25940247 1.679 NM_005074
SLC17A1
solute carrier family 17 (sodium phosphate), member 1
chr16_-_31054563 1.674 NM_002773
PRSS8
protease, serine, 8
chr19_+_44886785 1.673 NM_020129
NM_203471
LGALS14

lectin, galactoside-binding, soluble, 14

chrX_+_128741578 1.663 SASH3
SAM and SH3 domain containing 3
chr6_+_37081387 1.650 NM_173558
FGD2
FYVE, RhoGEF and PH domain containing 2
chr1_+_557269 1.610


chr6_-_34632061 1.593 NM_012391
SPDEF
SAM pointed domain containing ets transcription factor
chr7_+_18296569 1.585 HDAC9
histone deacetylase 9
chr16_+_29581783 1.580 NM_001030288
SPN
sialophorin
chr12_+_111900650 1.574 NM_001032731
NM_002535
NM_016817
OAS2


2'-5'-oligoadenylate synthetase 2, 69/71kDa


chr11_+_22652894 1.563 NM_005256
GAS2
growth arrest-specific 2
chr7_-_150385867 1.548 CDK5
cyclin-dependent kinase 5
chr2_+_218954995 1.546 NM_000578
SLC11A1
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
chr3_-_33675484 1.517 CLASP2
cytoplasmic linker associated protein 2
chr14_-_106241445 1.501 IGHV4-31
IGHV1-69
IGHA1
IGHG1
IGHG3
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 1-69
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
chr19_+_11510578 1.498 NM_001299
CNN1
calponin 1, basic, smooth muscle
chr13_-_45640679 1.496 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr2_+_228386800 1.488 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr11_+_22652957 1.479 GAS2
growth arrest-specific 2
chr19_-_60360768 1.478 NM_000363
TNNI3
troponin I type 3 (cardiac)
chr2_-_85490984 1.477 CAPG
capping protein (actin filament), gelsolin-like
chrX_+_128741562 1.473 NM_018990
SASH3
SAM and SH3 domain containing 3
chr13_+_112860968 1.471 NM_003891
PROZ
protein Z, vitamin K-dependent plasma glycoprotein
chr11_-_64459910 1.459 NM_130769
GPHA2
glycoprotein hormone alpha 2
chr11_+_64694200 1.451 NM_001008778
SPDYC
speedy homolog C (Xenopus laevis)
chr12_-_120725210 1.440 LOC338799
hypothetical LOC338799
chr14_-_106240998 1.436 IGHV1-69
IGHG1
immunoglobulin heavy variable 1-69
immunoglobulin heavy constant gamma 1 (G1m marker)
chr9_-_129707392 1.425 LOC100131355
ST6GALNAC6
hypothetical protein LOC100131355
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr17_-_36346240 1.425 KRT23
keratin 23 (histone deacetylase inducible)
chr11_-_60880799 1.424 NM_001161452
CYBASC3
cytochrome b, ascorbate dependent 3
chr20_+_71230 1.417 NM_030931
DEFB126
defensin, beta 126
chr7_+_100037817 1.410 NM_002593
PCOLCE
procollagen C-endopeptidase enhancer
chr6_-_41823056 1.407 NM_001166424
NM_002630
PGC

progastricsin (pepsinogen C)

chr10_+_82287637 1.389 NM_207372
SH2D4B
SH2 domain containing 4B
chr22_+_39404940 1.369 NM_005297
MCHR1
melanin-concentrating hormone receptor 1
chr10_-_76529253 1.347 NM_016364
DUSP13
dual specificity phosphatase 13
chr11_-_62753574 1.341 NM_199352
SLC22A25
solute carrier family 22, member 25
chr19_+_61624 1.340 NM_001005240
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr17_+_16259636 1.336 TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr2_+_169367345 1.335 NM_001039724
NM_001171632
NM_052946
NOSTRIN


nitric oxide synthase trafficker


chr6_+_33151703 1.322 NM_002121
HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chr19_-_40996040 1.312 NM_021232
PRODH2
proline dehydrogenase (oxidase) 2
chr16_+_21152516 1.312 NM_145865
ANKS4B
ankyrin repeat and sterile alpha motif domain containing 4B
chr22_+_40416492 1.303 NM_001142964
C22orf46
chromosome 22 open reading frame 46
chr5_-_121842680 1.288


chr12_-_55917134 1.287 NDUFA4L2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr21_+_34112456 1.285 ITSN1
intersectin 1 (SH3 domain protein)
chr14_+_87560646 1.280 LOC283587
hypothetical protein LOC283587
chr22_-_21814208 1.279 NM_014433
RTDR1
rhabdoid tumor deletion region gene 1
chr6_-_109795925 1.279 CD164
CD164 molecule, sialomucin
chr19_-_56582997 1.274 NM_001161748
NM_030657
LIM2

lens intrinsic membrane protein 2, 19kDa

chr19_-_10311262 1.267 NM_002162
ICAM3
intercellular adhesion molecule 3
chr19_+_52113772 1.260 NM_004491
GRLF1
glucocorticoid receptor DNA binding factor 1
chr12_+_14429499 1.256 ATF7IP
activating transcription factor 7 interacting protein
chr19_+_56420181 1.248 CD33
CD33 molecule
chr12_+_53177758 1.239 NM_005337
NCKAP1L
NCK-associated protein 1-like
chr19_-_63715135 1.235 NM_012254
SLC27A5
solute carrier family 27 (fatty acid transporter), member 5
chr7_-_100077072 1.233 NM_003227
TFR2
transferrin receptor 2
chr19_-_53914768 1.232 NM_001130915
MAMSTR
MEF2 activating motif and SAP domain containing transcriptional regulator
chr10_+_4995453 1.231 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr1_+_179269761 1.229 MR1
major histocompatibility complex, class I-related
chr14_-_23846993 1.228 CIDEB
cell death-inducing DFFA-like effector b
chr7_-_1562272 1.209 NM_001097620
TMEM184A
transmembrane protein 184A
chr1_+_152560179 1.196 NM_080429
AQP10
aquaporin 10
chr1_+_154178103 1.183 NM_181885
RXFP4
relaxin/insulin-like family peptide receptor 4
chr11_+_66927955 1.183 TBC1D10C
TBC1 domain family, member 10C
chr2_+_68815416 1.178 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr1_-_154988647 1.175 NM_001126051
NM_001126050
HDGF

hepatoma-derived growth factor

chr11_+_47236072 1.171 NM_001130101
NM_005693
NR1H3

nuclear receptor subfamily 1, group H, member 3

chr6_+_31016755 1.164 NM_080870
DPCR1
diffuse panbronchiolitis critical region 1
chr17_+_16259573 1.162 NM_016113
TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr11_+_62813947 1.151 NM_001039752
SLC22A10
solute carrier family 22, member 10
chr2_-_68952006 1.144 NM_014482
BMP10
bone morphogenetic protein 10
chr8_-_38127489 1.132 NM_000349
STAR
steroidogenic acute regulatory protein
chr1_+_116744992 1.131 ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr12_-_51887318 1.130 ITGB7
integrin, beta 7
chr2_+_74913289 1.129 NM_000189
HK2
hexokinase 2
chr6_+_70633168 1.127 NM_001858
COL19A1
collagen, type XIX, alpha 1
chr22_-_34886727 1.123 NM_145640
APOL3
apolipoprotein L, 3
chr1_+_179269766 1.122 MR1
major histocompatibility complex, class I-related
chr1_+_45251007 1.109 UROD
uroporphyrinogen decarboxylase
chr10_-_70846573 1.104 NM_001057
TACR2
tachykinin receptor 2
chr11_-_5130174 1.099 NM_012375
OR52A1
olfactory receptor, family 52, subfamily A, member 1
chr7_+_73248308 1.092 EIF4H
eukaryotic translation initiation factor 4H
chr17_+_72958330 1.091 SEPT9
septin 9
chr2_-_85490997 1.090 NM_001747
CAPG
capping protein (actin filament), gelsolin-like
chr12_+_47975168 1.088 NM_006262
PRPH
peripherin
chr12_+_69148120 1.088


chr16_-_20495126 1.084 NM_001105069
NM_182617
ACSM2B

acyl-CoA synthetase medium-chain family member 2B

chr8_-_86477585 1.084 NM_001128829
NM_001128830
NM_001128831
NM_001738
CA1



carbonic anhydrase I



chr4_+_40032146 1.084 NM_017581
CHRNA9
cholinergic receptor, nicotinic, alpha 9
chr6_+_64289585 1.079 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr5_+_34723420 1.075 NM_001145523
RAI14
retinoic acid induced 14
chr14_-_23846904 1.073 CIDEB
cell death-inducing DFFA-like effector b
chr1_+_116455898 1.070 NM_152367
MAB21L3
mab-21-like 3 (C. elegans)
chr19_+_60851207 1.066 CCDC106
coiled-coil domain containing 106
chr19_-_12802206 1.064 NM_001080997
RTBDN
retbindin
chr11_+_71580816 1.060 NM_016729
FOLR1
folate receptor 1 (adult)
chr5_-_176763789 1.048 F12
coagulation factor XII (Hageman factor)
chrX_-_55074125 1.036 NM_000032
NM_001037967
NM_001037968
ALAS2


aminolevulinate, delta-, synthase 2


chr16_-_66590856 1.032 NM_022355
DPEP2
dipeptidase 2
chr10_-_104201234 1.029 NM_024886
C10orf95
chromosome 10 open reading frame 95
chr10_-_121286034 1.023 NM_002925
RGS10
regulator of G-protein signaling 10
chr12_-_52016270 1.023 NM_001173467
SP7
Sp7 transcription factor
chr12_-_9804682 1.022 NM_001781
CD69
CD69 molecule
chr18_+_70317548 1.016 CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr10_-_75080784 1.012 NM_024875
SYNPO2L
synaptopodin 2-like
chr1_-_114215768 1.011 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr21_-_45165204 1.010 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr1_+_111215343 0.999 NM_001040033
CD53
CD53 molecule
chr12_+_102859354 0.997 HSP90B1
heat shock protein 90kDa beta (Grp94), member 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.05 2.21e-03 GO:0050776 regulation of immune response
2.06 2.94e-03 GO:0071702 organic substance transport
3.52 1.08e-02 GO:0006959 humoral immune response
1.59 3.54e-02 GO:0006629 lipid metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.48 2.39e-05 GO:0005576 extracellular region
1.78 9.30e-05 GO:0005615 extracellular space
1.61 8.02e-04 GO:0044421 extracellular region part
1.26 1.04e-03 GO:0071944 cell periphery
1.26 1.17e-03 GO:0005886 plasma membrane
4.73 9.55e-03 GO:0032994 protein-lipid complex
4.73 9.55e-03 GO:0034358 plasma lipoprotein particle
1.35 1.09e-02 GO:0044459 plasma membrane part
1.44 3.90e-02 GO:0005887 integral to plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.01 1.34e-02 GO:0005179 hormone activity
7.64 3.19e-02 GO:0048019 receptor antagonist activity
13.25 3.52e-02 GO:0032052 bile acid binding
1.38 4.57e-02 GO:0004872 receptor activity