Motif ID: RORA.p2

Z-value: 0.784


Transcription factors associated with RORA.p2:

Gene SymbolEntrez IDGene Name
RORA 6095 RAR-related orphan receptor A



Activity profile for motif RORA.p2.

activity profile for motif RORA.p2


Sorted Z-values histogram for motif RORA.p2

Sorted Z-values for motif RORA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RORA.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_186969202 1.510 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr3_+_9919295 0.927 NM_153483
IL17RE
interleukin 17 receptor E
chr1_-_233879617 0.873 NM_001098722
GNG4
guanine nucleotide binding protein (G protein), gamma 4
chr14_-_69725342 0.823 NM_033262
NM_058240
NM_182932
NM_183002
SLC8A3



solute carrier family 8 (sodium/calcium exchanger), member 3



chr7_+_101715137 0.750 SH2B2
SH2B adaptor protein 2
chr7_+_101715110 0.673 NM_020979
SH2B2
SH2B adaptor protein 2
chr17_+_68672705 0.646 NM_001050
SSTR2
somatostatin receptor 2
chr5_+_38294289 0.574 NM_152403
EGFLAM
EGF-like, fibronectin type III and laminin G domains
chr17_-_31332568 0.562 NM_004590
CCL16
chemokine (C-C motif) ligand 16
chr18_+_30327243 0.540 NM_001198945
NM_001392
NM_032975
NM_032979
DTNA



dystrobrevin, alpha



chr18_-_54447168 0.515 NM_052947
ALPK2
alpha-kinase 2
chr5_+_38294417 0.512 EGFLAM
EGF-like, fibronectin type III and laminin G domains
chr9_-_115877104 0.505 AMBP
alpha-1-microglobulin/bikunin precursor
chr11_-_2116048 0.501 IGF2
insulin-like growth factor 2 (somatomedin A)
chr18_+_30327341 0.500 DTNA
dystrobrevin, alpha
chr3_-_127382051 0.474 ALDH1L1
aldehyde dehydrogenase 1 family, member L1
chr10_-_52315390 0.472 A1CF
APOBEC1 complementation factor
chr6_-_112033752 0.458 TRAF3IP2
TRAF3 interacting protein 2
chr5_+_38294613 0.448


chr6_-_112033775 0.444 TRAF3IP2
TRAF3 interacting protein 2
chr1_+_67404756 0.435 NM_144701
IL23R
interleukin 23 receptor
chr11_-_47572478 0.435 NM_031909
C1QTNF4
C1q and tumor necrosis factor related protein 4
chr14_-_22825148 0.413 NM_020834
HOMEZ
homeobox and leucine zipper encoding
chr4_+_52612197 0.403 NM_145263
SPATA18
spermatogenesis associated 18 homolog (rat)
chr10_-_105835609 0.396 NM_000494
COL17A1
collagen, type XVII, alpha 1
chr7_+_18501876 0.378 NM_014707
NM_178423
HDAC9

histone deacetylase 9

chr11_-_119514011 0.359 TRIM29
tripartite motif containing 29
chr15_-_63457378 0.343 NM_004884
IGDCC3
immunoglobulin superfamily, DCC subclass, member 3
chr4_+_110968594 0.327 NM_006583
RRH
retinal pigment epithelium-derived rhodopsin homolog
chr10_-_52315436 0.315 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr6_-_152664906 0.311 SYNE1
spectrin repeat containing, nuclear envelope 1
chr3_+_1109619 0.303 NM_014461
CNTN6
contactin 6
chr8_+_120289735 0.299 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr1_-_176205970 0.285 SEC16B
SEC16 homolog B (S. cerevisiae)
chr19_-_53832381 0.283 NM_001352
DBP
D site of albumin promoter (albumin D-box) binding protein
chr10_-_71811353 0.276 NM_207119
LRRC20
leucine rich repeat containing 20
chr11_+_2116486 0.266


chr6_+_43846735 0.257 VEGFA
vascular endothelial growth factor A
chr6_+_43846372 0.248 VEGFA
vascular endothelial growth factor A
chr11_+_13255967 0.242 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr8_-_72436832 0.238 EYA1
eyes absent homolog 1 (Drosophila)
chr6_+_43845915 0.236 NM_001025366
NM_001025367
NM_001025368
NM_001025369
NM_001025370
NM_001033756
NM_001171622
NM_001171623
NM_001171624
NM_001171625
NM_001171626
NM_001171627
NM_001171628
NM_001171629
NM_001171630
NM_003376
VEGFA















vascular endothelial growth factor A















chr17_-_23721430 0.232 VTN
vitronectin
chr15_-_50270856 0.227 NM_016194
GNB5
guanine nucleotide binding protein (G protein), beta 5
chr11_-_2116360 0.227 IGF2
insulin-like growth factor 2 (somatomedin A)
chr4_+_155703581 0.223 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr11_-_2116775 0.216 NM_000612
IGF2
insulin-like growth factor 2 (somatomedin A)
chr8_-_142307854 0.206 NM_001080431
SLC45A4
solute carrier family 45, member 4
chr19_+_7607976 0.204 NM_001127396
NM_006949
STXBP2

syntaxin binding protein 2

chr11_-_64283945 0.203 PYGM
phosphorylase, glycogen, muscle
chr18_+_53967544 0.203 NM_001144965
NM_001144968
NM_001144969
NM_001144971
NEDD4L



neural precursor cell expressed, developmentally down-regulated 4-like



chr3_-_127382093 0.200 NM_012190
ALDH1L1
aldehyde dehydrogenase 1 family, member L1
chr2_-_215711313 0.188 NM_173076
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr17_+_7474128 0.182 SHBG
sex hormone-binding globulin
chr16_-_15095590 0.182 NM_018427
RRN3
RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
chr6_+_43845875 0.177 VEGFA
vascular endothelial growth factor A
chr6_-_24491498 0.177 NM_001195610
DCDC2
doublecortin domain containing 2
chr11_+_13255905 0.176 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr6_+_37429776 0.175 RNF8
ring finger protein 8
chr19_-_60272708 0.171 NM_138412
RDH13
retinol dehydrogenase 13 (all-trans/9-cis)
chr11_+_13255836 0.169 NM_001030272
NM_001030273
NM_001178
ARNTL


aryl hydrocarbon receptor nuclear translocator-like


chr6_+_37429800 0.169 RNF8
ring finger protein 8
chrX_-_71443725 0.168 NM_001144886
CITED1
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
chr16_-_1772572 0.163 SPSB3
splA/ryanodine receptor domain and SOCS box containing 3
chr17_-_17426469 0.158 NM_007169
PEMT
phosphatidylethanolamine N-methyltransferase
chr3_-_24511180 0.158 NM_001128176
NM_000461
NM_001128177
THRB


thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)


chr3_-_185578621 0.155 NM_000460
NM_001177597
NM_001177598
THPO


thrombopoietin


chr1_-_176205672 0.155 NM_033127
SEC16B
SEC16 homolog B (S. cerevisiae)
chr14_-_74458897 0.150 NM_031464
RPS6KL1
ribosomal protein S6 kinase-like 1
chr22_-_31732648 0.147 NM_003490
NM_133633
SYN3

synapsin III

chr4_+_155707089 0.144 FGB
fibrinogen beta chain
chr16_-_1772577 0.143 NM_080861
SPSB3
splA/ryanodine receptor domain and SOCS box containing 3
chr14_-_34661156 0.143 PPP2R3C
protein phosphatase 2, regulatory subunit B'', gamma
chr11_+_13255948 0.141 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr6_+_158654464 0.141 TULP4
tubby like protein 4
chr11_+_13255952 0.140 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr4_+_39084867 0.139 NM_175737
KLB
klotho beta
chr22_+_40286957 0.137 NM_014460
CSDC2
cold shock domain containing C2, RNA binding
chr6_-_52217185 0.135 NM_052872
IL17F
interleukin 17F
chr16_-_1772305 0.132 SPSB3
splA/ryanodine receptor domain and SOCS box containing 3
chr2_+_121271336 0.132 NM_005270
GLI2
GLI family zinc finger 2
chr10_-_121286034 0.132 NM_002925
RGS10
regulator of G-protein signaling 10
chr10_-_103568197 0.130 NM_001142434
NM_012215
MGEA5

meningioma expressed antigen 5 (hyaluronidase)

chr11_+_13255913 0.130 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr19_-_3930828 0.121 EEF2
eukaryotic translation elongation factor 2
chr11_+_55869996 0.121 NM_001002907
OR8K1
olfactory receptor, family 8, subfamily K, member 1
chr3_+_51837608 0.120 NM_001085479
IQCF3
IQ motif containing F3
chr16_+_16233979 0.119 NOMO2
NODAL modulator 2
chr17_+_7474177 0.118 NM_001040
NM_001146279
NM_001146280
NM_001146281
SHBG



sex hormone-binding globulin



chr16_+_57091546 0.112 NDRG4
NDRG family member 4
chr7_-_100124805 0.111 NM_022574
GIGYF1
GRB10 interacting GYF protein 1
chr1_-_246869181 0.111 NM_001001827
OR2T35
olfactory receptor, family 2, subfamily T, member 35
chr4_-_151990061 0.110 LRBA
LPS-responsive vesicle trafficking, beach and anchor containing
chr17_-_17426416 0.110 PEMT
phosphatidylethanolamine N-methyltransferase
chr11_+_13255925 0.109 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr17_-_70554674 0.109 ATP5H
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d
chr16_+_16233989 0.108 NOMO2
NODAL modulator 2
chr2_+_170742900 0.108 NM_001083615
NM_001171642
NM_138995
MYO3B


myosin IIIB


chr14_+_93562500 0.105 OTUB2
OTU domain, ubiquitin aldehyde binding 2
chr17_-_70554635 0.104 NM_001003785
NM_006356
ATP5H

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d

chr11_+_33306652 0.102 HIPK3
homeodomain interacting protein kinase 3
chr13_+_108046500 0.100 NM_015011
MYO16
myosin XVI
chr12_-_40824699 0.096 NM_001099650
NM_173601
GXYLT1

glucoside xylosyltransferase 1

chr4_+_85723080 0.094 NM_001263
CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr12_+_54910086 0.094 NM_173596
SLC39A5
solute carrier family 39 (metal ion transporter), member 5
chr1_-_51583281 0.088 NM_001144832
TTC39A
tetratricopeptide repeat domain 39A
chr12_+_119617060 0.087


chr11_-_72057755 0.087 NM_001146209
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr16_+_16233972 0.087 NOMO2
NODAL modulator 2
chr11_-_70350509 0.085 SHANK2
SH3 and multiple ankyrin repeat domains 2
chr16_+_16233996 0.085 NOMO1
NODAL modulator 1
chr7_-_128203079 0.085 NM_001708
OPN1SW
opsin 1 (cone pigments), short-wave-sensitive
chr17_-_2250967 0.084 NM_020310
MNT
MAX binding protein
chr14_-_22825072 0.083 HOMEZ
homeobox and leucine zipper encoding
chr5_-_150501393 0.081 NM_001193544
ANXA6
annexin A6
chr2_-_165186232 0.078 GRB14
growth factor receptor-bound protein 14
chr11_-_119104463 0.077 NM_002855
NM_203285
NM_203286
PVRL1


poliovirus receptor-related 1 (herpesvirus entry mediator C)


chr16_+_16233955 0.076 NOMO2
NODAL modulator 2
chr4_+_25931282 0.076 RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr17_+_7495436 0.076 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr6_+_43846155 0.076 VEGFA
vascular endothelial growth factor A
chr12_+_25096472 0.074 NM_006152
LRMP
lymphoid-restricted membrane protein
chr17_+_23393744 0.073 NM_016231
NLK
nemo-like kinase
chr17_+_38250122 0.072 NM_001158
NM_009590
AOC2

amine oxidase, copper containing 2 (retina-specific)

chr7_+_97574054 0.071 NM_014916
LMTK2
lemur tyrosine kinase 2
chr17_-_2977594 0.067 NM_003555
OR1G1
olfactory receptor, family 1, subfamily G, member 1
chr19_-_16111695 0.064


chrX_-_2892288 0.064 NM_000047
ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chrX_+_12834659 0.063 NM_138636
TLR8
toll-like receptor 8
chr16_-_28210867 0.062


chrX_+_10084984 0.059 NM_001830
CLCN4
chloride channel 4
chr19_+_47073029 0.059 NM_001783
NM_021601
CD79A

CD79a molecule, immunoglobulin-associated alpha

chr16_+_16234008 0.058 NOMO1
NODAL modulator 1
chr2_+_27358800 0.057 NM_032546
NM_187841
TRIM54

tripartite motif containing 54

chr9_-_113585593 0.055 NM_173521
C9orf84
chromosome 9 open reading frame 84
chr6_+_15353681 0.055 JARID2
jumonji, AT rich interactive domain 2
chr19_+_1220244 0.055 NM_001280
CIRBP
cold inducible RNA binding protein
chr12_-_51887266 0.054 NM_000889
ITGB7
integrin, beta 7
chr3_-_123716454 0.054 KPNA1
karyopherin alpha 1 (importin alpha 5)
chr20_-_1257782 0.053 SDCBP2
syndecan binding protein (syntenin) 2
chr22_-_18807805 0.051 PI4KAP2
PI4KAP1
phosphatidylinositol 4-kinase, catalytic, alpha pseudogene 2
phosphatidylinositol 4-kinase, catalytic, alpha pseudogene 1
chrX_-_32083506 0.050 NM_004013
NM_004020
NM_004021
NM_004022
NM_004023
DMD




dystrophin




chr2_-_191580567 0.050 STAT1
signal transducer and activator of transcription 1, 91kDa
chr1_-_104040594 0.049 NM_001008221
AMY1A
amylase, alpha 1A (salivary)
chr12_-_55134692 0.049 NM_012064
MIP
major intrinsic protein of lens fiber
chr2_+_232951487 0.045 NM_001632
ALPP
alkaline phosphatase, placental
chr14_-_19252330 0.045 NM_001197287
OR11H2
olfactory receptor, family 11, subfamily H, member 2
chr2_-_228206045 0.043 NM_001162483
NM_020161
C2orf83

chromosome 2 open reading frame 83

chr1_+_149877955 0.043 SNX27
sorting nexin family member 27
chr2_+_138975946 0.042


chr16_+_24174374 0.041 NM_006539
CACNG3
calcium channel, voltage-dependent, gamma subunit 3
chr1_+_46413335 0.041 NM_005727
TSPAN1
tetraspanin 1
chr16_-_45735333 0.040 NETO2
neuropilin (NRP) and tolloid (TLL)-like 2
chr5_+_137716169 0.040 NM_016604
KDM3B
lysine (K)-specific demethylase 3B
chr2_-_138762909 0.040


chrX_-_114703273 0.040


chr17_-_36113502 0.040 NM_019016
KRT24
keratin 24
chr17_+_70554914 0.039 KCTD2
potassium channel tetramerisation domain containing 2
chr9_+_124321239 0.038 NM_001004452
OR1J4
olfactory receptor, family 1, subfamily J, member 4
chr19_+_8384181 0.038 NM_001005415
NM_001005416
NM_016496
MARCH2


membrane-associated ring finger (C3HC4) 2


chr3_+_32408346 0.038 CMTM7
CKLF-like MARVEL transmembrane domain containing 7
chr12_+_54672766 0.037 RAB5B
RAB5B, member RAS oncogene family
chr7_+_111850367 0.036 NM_001007245
NM_001197080
IFRD1

interferon-related developmental regulator 1

chr18_+_61568467 0.033 NM_033646
CDH7
cadherin 7, type 2
chr1_+_40635058 0.032 NM_001198980
SMAP2
small ArfGAP2
chr14_-_91268136 0.032 NM_024764
CATSPERB
cation channel, sperm-associated, beta
chr2_+_38005875 0.032 NM_001170791
FAM82A1
family with sequence similarity 82, member A1
chr9_-_21375258 0.031 NM_000605
IFNA2
interferon, alpha 2
chr16_+_1773004 0.030 NUBP2
nucleotide binding protein 2 (MinD homolog, E. coli)
chr15_+_100319349 0.027 LOC100134445
WASH1
WASH3P
hypothetical LOC100134445
WAS protein family homolog 1
WAS protein family homolog 3 pseudogene
chr7_-_86433139 0.026 NM_152748
KIAA1324L
KIAA1324-like
chr10_-_103568169 0.026 MGEA5
meningioma expressed antigen 5 (hyaluronidase)
chr3_-_123716471 0.026 NM_002264
KPNA1
karyopherin alpha 1 (importin alpha 5)
chr11_-_6418705 0.026 NM_000613
HPX
hemopexin
chr11_+_55617328 0.026 NM_001003750
OR8I2
olfactory receptor, family 8, subfamily I, member 2
chr1_+_196148241 0.025 NM_001014434
LHX9
LIM homeobox 9
chr14_-_67211081 0.025 NM_006370
VTI1B
vesicle transport through interaction with t-SNAREs homolog 1B (yeast)
chr6_+_42991704 0.024 NM_138296
PTCRA
pre T-cell antigen receptor alpha
chr12_-_51887318 0.024 ITGB7
integrin, beta 7
chr9_-_35093189 0.024 STOML2
stomatin (EPB72)-like 2
chr22_-_20235372 0.024 NM_001128635
RIMBP3B
RIMS binding protein 3B
chr17_+_37941790 0.023 NAGLU
N-acetylglucosaminidase, alpha
chr19_-_40411418 0.023 NM_152481
FAM187B
family with sequence similarity 187, member B
chr7_-_150385912 0.022 NM_001164410
NM_004935
CDK5

cyclin-dependent kinase 5

chr12_-_55637648 0.021 NM_003708
RDH16
retinol dehydrogenase 16 (all-trans)
chrX_-_102661072 0.021 NM_080879
RAB40A
RAB40A, member RAS oncogene family
chr1_-_201422490 0.021 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr14_+_28311740 0.020 C14orf23
chromosome 14 open reading frame 23
chrX_-_108611940 0.020 NM_001522
GUCY2F
guanylate cyclase 2F, retinal
chr13_-_26232777 0.020 NM_005288
GPR12
G protein-coupled receptor 12
chr1_-_201422533 0.019 NM_001276
CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr5_-_54866126 0.018 NM_003711
NM_176895
RNF138P1
PPAP2A

ring finger protein 138 pseudogene 1
phosphatidic acid phosphatase type 2A

chr6_-_34209250 0.018 NM_000841
GRM4
glutamate receptor, metabotropic 4
chrX_-_57164575 0.018 NM_001006681
NM_001006682
NM_001006683
SPIN2B


spindlin family, member 2B


chr22_+_20101661 0.017 NM_015094
HIC2
hypermethylated in cancer 2
chr19_-_21943 0.017 WASH1
WASH3P
WASH5P
WAS protein family homolog 1
WAS protein family homolog 3 pseudogene
WAS protein family homolog 5 pseudogene
chr14_+_19598043 0.016 NM_001004717
OR4L1
olfactory receptor, family 4, subfamily L, member 1
chr17_-_36981830 0.016 NM_000226
KRT9
keratin 9
chr15_-_43209348 0.016 NM_144565
DUOXA1
dual oxidase maturation factor 1
chr17_+_37941715 0.015 NAGLU
N-acetylglucosaminidase, alpha

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
73.39 3.41e-03 GO:0034314 Arp2/3 complex-mediated actin nucleation
48.93 1.68e-02 GO:0045010 actin nucleation

Nothing significant found in compartment category.

Nothing significant found in function category.