Motif ID: LHX3,4.p2

Z-value: 1.295


Transcription factors associated with LHX3,4.p2:

Gene SymbolEntrez IDGene Name
LHX3 8022 LIM homeobox 3
LHX4 89884 LIM homeobox 4



Activity profile for motif LHX3,4.p2.

activity profile for motif LHX3,4.p2


Sorted Z-values histogram for motif LHX3,4.p2

Sorted Z-values for motif LHX3,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LHX3,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_88155360 4.486 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr12_+_52697160 1.964 HOXC5
HOXC6
homeobox C5
homeobox C6
chr7_-_25234582 1.945 NM_022150
NPVF
neuropeptide VF precursor
chrX_-_13744933 1.901 GPM6B
glycoprotein M6B
chr12_+_52696908 1.804 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr19_-_56612653 1.574 NM_001171156
NM_001171157
NM_001171158
NM_001171159
NM_001171160
NM_001171161
NM_033130
SIGLEC10






sialic acid binding Ig-like lectin 10






chr1_+_196874839 1.468 PTPRC
protein tyrosine phosphatase, receptor type, C
chrX_-_10761729 1.399 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr1_+_166516901 1.336 NM_005149
TBX19
T-box 19
chr13_-_83354425 1.334 SLITRK1
SLIT and NTRK-like family, member 1
chr17_+_19917420 1.319 SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chrX_-_55074125 1.167 NM_000032
NM_001037967
NM_001037968
ALAS2


aminolevulinate, delta-, synthase 2


chr10_-_50066386 1.159 NM_001010863
C10orf128
chromosome 10 open reading frame 128
chr1_-_114215768 1.133 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr1_+_117345894 1.074 NM_004258
CD101
CD101 molecule
chr9_-_116305273 1.048 NM_001083885
DFNB31
deafness, autosomal recessive 31
chr16_+_11966464 1.034 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr3_+_63928459 1.034 NM_001128149
ATXN7
ataxin 7
chr7_-_13992351 1.022 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr12_+_52708460 0.991 NM_004503
HOXC6
homeobox C6
chr22_+_38627129 0.956 GRAP2
GRB2-related adaptor protein 2
chr12_-_101396459 0.954 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr3_-_57209319 0.952 NM_003865
HESX1
HESX homeobox 1
chr22_+_38627031 0.921 NM_004810
GRAP2
GRB2-related adaptor protein 2
chr3_-_143230124 0.868 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr9_-_14076901 0.852 NFIB
nuclear factor I/B
chr19_-_53841064 0.850 NM_001217
CA11
carbonic anhydrase XI
chrX_+_70682204 0.848 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr9_-_205892 0.834 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr16_+_2749934 0.829


chr8_-_42742729 0.826 NM_004198
CHRNA6
cholinergic receptor, nicotinic, alpha 6
chr7_+_128802719 0.823 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr2_-_215711313 0.806 NM_173076
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr10_+_91488704 0.759 KIF20B
kinesin family member 20B
chr12_-_16652202 0.750 NM_001001395
LMO3
LIM domain only 3 (rhombotin-like 2)
chr8_-_91164100 0.736 NM_004929
CALB1
calbindin 1, 28kDa
chrX_-_13745108 0.735 GPM6B
glycoprotein M6B
chr5_+_67622242 0.732 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr7_-_75794919 0.722 YWHAG
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
chr1_-_158815895 0.719 NM_001184879
NM_001184881
NM_001184882
NM_003874
CD84



CD84 molecule



chr1_+_196874867 0.693 PTPRC
protein tyrosine phosphatase, receptor type, C
chr20_+_56919233 0.685 GNAS
GNAS complex locus
chr15_+_32048380 0.684 NM_012125
CHRM5
cholinergic receptor, muscarinic 5
chr2_+_161981138 0.683 TBR1
T-box, brain, 1
chr4_+_88748704 0.682 NM_014208
DSPP
dentin sialophosphoprotein
chr18_+_27281729 0.649 NM_001944
DSG3
desmoglein 3
chr13_-_98708549 0.647 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr2_+_161981046 0.639 TBR1
T-box, brain, 1
chr2_+_161980865 0.633 NM_006593
TBR1
T-box, brain, 1
chr19_+_14554895 0.632 NM_207390
CLEC17A
C-type lectin domain family 17, member A
chr11_+_33306652 0.624 HIPK3
homeodomain interacting protein kinase 3
chr8_-_72436519 0.624 EYA1
eyes absent homolog 1 (Drosophila)
chr12_-_10173947 0.615 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr4_-_120462705 0.612 NM_000134
FABP2
fatty acid binding protein 2, intestinal
chr5_+_156628929 0.611 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr2_-_80384454 0.611 LRRTM1
leucine rich repeat transmembrane neuronal 1
chrX_-_13745134 0.611 GPM6B
glycoprotein M6B
chr15_+_22832198 0.609 SNRPN
small nuclear ribonucleoprotein polypeptide N
chr3_+_115099007 0.608 NM_001172105
GRAMD1C
GRAM domain containing 1C
chrX_-_13745234 0.604 NM_001001995
NM_001001996
NM_005278
GPM6B


glycoprotein M6B


chr3_+_179759181 0.588 NM_005832
KCNMB2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chrX_-_102418329 0.581 NM_001012979
TCEAL5
transcription elongation factor A (SII)-like 5
chrX_+_134803450 0.581 NM_018666
SAGE1
sarcoma antigen 1
chr5_+_166644420 0.573 NM_001122679
ODZ2
odz, odd Oz/ten-m homolog 2 (Drosophila)
chr3_+_46386636 0.570 NM_000579
NM_001100168
CCR5

chemokine (C-C motif) receptor 5

chr6_+_73133152 0.569 NM_001168411
RIMS1
regulating synaptic membrane exocytosis 1
chr1_-_143708467 0.567 NM_001195260
PDE4DIP
phosphodiesterase 4D interacting protein
chr5_+_127012611 0.566 NM_001048252
CTXN3
cortexin 3
chr13_-_83354474 0.565 NM_052910
SLITRK1
SLIT and NTRK-like family, member 1
chr2_-_158008763 0.560 NM_004288
CYTIP
cytohesin 1 interacting protein
chr2_+_68815416 0.544 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr3_-_158704056 0.542 NM_001167915
NM_001167916
VEPH1

ventricular zone expressed PH domain homolog 1 (zebrafish)

chr6_-_32265489 0.541 NM_002586
PBX2
pre-B-cell leukemia homeobox 2
chr4_+_88790477 0.541 NM_001079911
NM_004407
DMP1

dentin matrix acidic phosphoprotein 1

chr1_+_196874759 0.530 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr7_+_129771865 0.519 NM_001127441
NM_001127442
NM_080385
CPA5


carboxypeptidase A5


chr2_+_169634330 0.517 DHRS9
dehydrogenase/reductase (SDR family) member 9
chr7_+_77307382 0.517 NM_001127357
NM_001127359
NM_020432
PHTF2


putative homeodomain transcription factor 2


chr2_+_158559936 0.515 NM_001135098
UPP2
uridine phosphorylase 2
chrX_+_107174855 0.512 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chr11_-_20138445 0.511 NM_001029865
DBX1
developing brain homeobox 1
chr3_+_152934393 0.506 NM_207365
AADACL2
arylacetamide deacetylase-like 2
chr5_-_22889192 0.501 CDH12
cadherin 12, type 2 (N-cadherin 2)
chrX_+_37524190 0.500 NM_000397
CYBB
cytochrome b-245, beta polypeptide
chr11_+_123600553 0.496 NM_001007249
OR8G2
olfactory receptor, family 8, subfamily G, member 2
chrX_-_15242589 0.487 NM_001012428
ASB11
ankyrin repeat and SOCS box containing 11
chr10_+_35466715 0.483 NM_183011
NM_183012
CREM

cAMP responsive element modulator

chr3_+_99733432 0.480 NM_005290
GPR15
G protein-coupled receptor 15
chr9_+_92603832 0.480 NM_001135052
NM_003177
SYK

spleen tyrosine kinase

chrX_-_131989963 0.479 NM_031907
USP26
ubiquitin specific peptidase 26
chr3_-_168674502 0.475 NM_006217
SERPINI2
serpin peptidase inhibitor, clade I (pancpin), member 2
chr17_-_1195096 0.472 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr6_+_53043729 0.468 NM_012347
FBXO9
F-box protein 9
chr7_+_37689903 0.463


chr11_-_58099884 0.457 NM_004811
LPXN
leupaxin
chr4_-_176970372 0.457 GPM6A
glycoprotein M6A
chr3_-_12561962 0.456 NM_001195279
LOC100129480
hypothetical protein LOC100129480
chr1_-_150398327 0.456 NM_001122965
RPTN
repetin
chr21_-_31107431 0.454 NM_175857
KRTAP8-1
keratin associated protein 8-1
chr14_+_66901237 0.454 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr6_+_31538934 0.453 NM_006674
HCP5
HLA complex P5
chr6_+_50789215 0.448 NM_172238
TFAP2D
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chr5_-_1935764 0.445 NM_016358
IRX4
iroquois homeobox 4
chr3_-_152517204 0.445 NM_023915
GPR87
G protein-coupled receptor 87
chr12_-_52281050 0.444 NM_001130059
ATF7
activating transcription factor 7
chr11_-_5766621 0.423 NM_001001913
OR52N1
olfactory receptor, family 52, subfamily N, member 1
chr15_+_89212888 0.421 NM_002569
FURIN
furin (paired basic amino acid cleaving enzyme)
chr12_-_101036407 0.419 NM_024057
NUP37
nucleoporin 37kDa
chr7_+_90177082 0.418 CDK14
cyclin-dependent kinase 14
chr1_+_158636987 0.416 NM_020335
VANGL2
vang-like 2 (van gogh, Drosophila)
chr11_+_59979857 0.415 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr3_-_9266251 0.414 NM_001033117
NM_014850
SRGAP3

SLIT-ROBO Rho GTPase activating protein 3

chr12_+_91620749 0.414 NM_001037671
NM_001178097
C12orf74

chromosome 12 open reading frame 74

chr1_-_245942679 0.413 NM_001005286
OR6F1
olfactory receptor, family 6, subfamily F, member 1
chr2_-_80385227 0.411 LRRTM1
leucine rich repeat transmembrane neuronal 1
chr4_-_54152480 0.407 NM_001126328
LNX1
ligand of numb-protein X 1
chr4_-_54152385 0.404 LNX1
ligand of numb-protein X 1
chr7_+_129057152 0.402 NM_001040110
NRF1
nuclear respiratory factor 1
chr11_-_118405288 0.399 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr2_-_207291364 0.397 NM_001093730
DYTN
dystrotelin
chr1_+_62835759 0.397 NM_014495
ANGPTL3
angiopoietin-like 3
chr13_+_47948586 0.395 RB1
retinoblastoma 1
chr1_+_173111306 0.394 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr12_+_54700955 0.392 NM_022465
IKZF4
IKAROS family zinc finger 4 (Eos)
chr6_+_152053323 0.390 NM_001122742
ESR1
estrogen receptor 1
chr20_-_51633042 0.389 NM_006526
ZNF217
zinc finger protein 217
chr3_-_54937001 0.389 NM_020678
LRTM1
leucine-rich repeats and transmembrane domains 1
chrX_+_37524250 0.386 CYBB
cytochrome b-245, beta polypeptide
chrX_+_115215985 0.383 NM_000686
AGTR2
angiotensin II receptor, type 2
chr4_+_166350620 0.381 NM_001161521
NM_001161522
KLHL2

kelch-like 2, Mayven (Drosophila)

chr3_+_188222337 0.381 NM_003032
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr14_-_46882144 0.379 NM_182830
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr1_-_151549790 0.377 NM_052891
PGLYRP3
peptidoglycan recognition protein 3
chr4_-_83566045 0.376


chr7_+_94135384 0.374 PEG10
paternally expressed 10
chr7_+_18296569 0.369 HDAC9
histone deacetylase 9
chr8_+_9990471 0.368 NM_001135671
MSRA
methionine sulfoxide reductase A
chr12_+_15590811 0.359 PTPRO
protein tyrosine phosphatase, receptor type, O
chr8_-_101384633 0.358 NM_015435
RNF19A
ring finger protein 19A
chr12_-_51887266 0.358 NM_000889
ITGB7
integrin, beta 7
chr12_+_130004404 0.348 NM_198827
GPR133
G protein-coupled receptor 133
chr21_-_30460841 0.346 NM_012131
CLDN17
claudin 17
chr12_-_51887318 0.345 ITGB7
integrin, beta 7
chr1_-_149681265 0.344 NM_207171
POGZ
pogo transposable element with ZNF domain
chr8_-_110730183 0.342 NM_001099747
NM_001099748
NM_001099749
NM_001099750
NM_017786
SYBU




syntabulin (syntaxin-interacting)




chr1_-_230717850 0.341 NM_020808
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr12_+_54672766 0.340 RAB5B
RAB5B, member RAS oncogene family
chr18_+_59767567 0.339 NM_001123366
HMSD
histocompatibility (minor) serpin domain containing
chrX_+_99726445 0.337 NM_022144
TNMD
tenomodulin
chr1_+_42773146 0.336 NM_001080850
CCDC30
coiled-coil domain containing 30
chr15_+_100175888 0.330 NM_001001674
OR4F15
olfactory receptor, family 4, subfamily F, member 15
chr16_-_3567354 0.329 NM_178844
NLRC3
NLR family, CARD domain containing 3
chr1_+_157067729 0.328 NM_002432
MNDA
myeloid cell nuclear differentiation antigen
chr8_+_22266256 0.328 PIWIL2
piwi-like 2 (Drosophila)
chr2_-_99238001 0.327 NM_175735
LYG2
lysozyme G-like 2
chr18_+_27210737 0.326 NM_001134453
NM_177986
DSG4

desmoglein 4

chr10_-_45131061 0.325 NM_001004297
OR13A1
olfactory receptor, family 13, subfamily A, member 1
chr10_-_33264491 0.325 NM_033668
ITGB1
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
chr8_+_55691179 0.324 NM_006269
RP1
retinitis pigmentosa 1 (autosomal dominant)
chr3_-_158703821 0.323 NM_001167911
NM_001167912
VEPH1

ventricular zone expressed PH domain homolog 1 (zebrafish)

chr13_-_40491405 0.323 ELF1
E74-like factor 1 (ets domain transcription factor)
chr6_-_155818728 0.323 NM_015718
NOX3
NADPH oxidase 3
chr3_-_102522093 0.322 NM_016247
IMPG2
interphotoreceptor matrix proteoglycan 2
chr4_-_116254381 0.320 NM_022569
NDST4
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
chr6_-_22405708 0.318 NM_000948
PRL
prolactin
chr12_-_101398429 0.316 IGF1
insulin-like growth factor 1 (somatomedin C)
chr8_+_7340777 0.313 NM_001037668
NM_001040705
DEFB107A
DEFB107B
defensin, beta 107A
defensin, beta 107B
chr5_+_6799100 0.312 NM_001171806
PAPD7
PAP associated domain containing 7
chrX_-_110542040 0.311 NM_178151
NM_001195553
NM_178152
NM_178153
DCX



doublecortin



chr6_-_29120930 0.308 NM_030903
OR2W1
olfactory receptor, family 2, subfamily W, member 1
chr6_-_136829705 0.306 NM_001198615
MAP7
microtubule-associated protein 7
chr4_-_57242492 0.306 NM_001145460
NM_032495
NM_139212
HOPX


HOP homeobox


chrX_+_78313124 0.306 NM_032553
GPR174
G protein-coupled receptor 174
chr12_-_10497195 0.306 NM_002259
NM_007328
KLRC1

killer cell lectin-like receptor subfamily C, member 1

chr1_+_154120170 0.305 SYT11
synaptotagmin XI
chr11_+_59580630 0.305 NM_001031666
NM_001031809
NM_006138
MS4A3


membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)


chr11_-_74478405 0.305 NM_001005285
OR2AT4
olfactory receptor, family 2, subfamily AT, member 4
chr15_+_92700167 0.304 NM_001159644
MCTP2
multiple C2 domains, transmembrane 2
chr1_+_242283129 0.304 NM_006352
ZNF238
zinc finger protein 238
chr7_-_135263737 0.302 MTPN
LUZP6
myotrophin
leucine zipper protein 6
chr7_-_86433139 0.302 NM_152748
KIAA1324L
KIAA1324-like
chr13_+_112349358 0.302 NM_207440
C13orf35
chromosome 13 open reading frame 35
chr1_+_40635058 0.301 NM_001198980
SMAP2
small ArfGAP2
chr17_+_21946563 0.298 NM_001190452
MTRNR2L1
MT-RNR2-like 1
chr4_-_184480572 0.297 NM_001185149
CLDN24
claudin 24
chrX_-_24575375 0.297 NM_001163265
NM_004845
PCYT1B

phosphate cytidylyltransferase 1, choline, beta

chr16_+_2593351 0.297 LOC652276
hypothetical LOC652276
chr1_-_92725017 0.296 NM_005263
GFI1
growth factor independent 1 transcription repressor
chrX_-_138552517 0.296 NM_001171877
NM_001171878
NM_001171879
NM_005369
MCF2



MCF.2 cell line derived transforming sequence



chr17_-_36192311 0.292 NM_181537
KRT27
keratin 27
chr7_-_122627235 0.290 NM_022444
SLC13A1
solute carrier family 13 (sodium/sulfate symporters), member 1
chr21_+_42697058 0.288 NM_001001895
NM_018961
UBASH3A

ubiquitin associated and SH3 domain containing A

chr2_+_178893216 0.287 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr4_-_77163609 0.287 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr12_+_54172413 0.286 NM_001005519
OR6C68
olfactory receptor, family 6, subfamily C, member 68
chr10_+_18589589 0.286 NM_000724
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr5_+_60969392 0.286 NM_173667
FLJ37543
hypothetical protein FLJ37543
chr2_+_121271336 0.284 NM_005270
GLI2
GLI family zinc finger 2
chr2_+_108604111 0.282 NM_001193484
LIMS1
LIM and senescent cell antigen-like domains 1
chr7_-_7724762 0.281 NM_002947
RPA3
replication protein A3, 14kDa

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.31 1.15e-04 GO:0007608 sensory perception of smell
1.24 6.62e-04 GO:0050896 response to stimulus
2.11 1.34e-03 GO:0007606 sensory perception of chemical stimulus
1.44 4.72e-02 GO:0003008 system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.33 9.73e-06 GO:0071944 cell periphery
1.33 1.32e-05 GO:0005886 plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.05 6.86e-08 GO:0004930 G-protein coupled receptor activity
1.65 9.26e-07 GO:0004872 receptor activity
1.76 9.73e-07 GO:0004888 transmembrane receptor activity
2.42 6.71e-06 GO:0004984 olfactory receptor activity
1.50 5.04e-05 GO:0004871 signal transducer activity
1.50 5.04e-05 GO:0060089 molecular transducer activity
6.76 1.60e-03 GO:0001608 nucleotide receptor activity, G-protein coupled
6.76 1.60e-03 GO:0045028 purinergic nucleotide receptor activity, G-protein coupled
5.28 1.56e-02 GO:0001614 purinergic nucleotide receptor activity
5.28 1.56e-02 GO:0016502 nucleotide receptor activity
4.69 4.33e-02 GO:0035586 purinergic receptor activity