Motif ID: TCF4_dimer.p2

Z-value: 2.629


Transcription factors associated with TCF4_dimer.p2:

Gene SymbolEntrez IDGene Name
TCF4 6925 transcription factor 4



Activity profile for motif TCF4_dimer.p2.

activity profile for motif TCF4_dimer.p2


Sorted Z-values histogram for motif TCF4_dimer.p2

Sorted Z-values for motif TCF4_dimer.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TCF4_dimer.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_201364050 5.354 ADORA1
adenosine A1 receptor
chr8_-_41641881 5.255 NM_001142445
NM_020478
NM_020480
ANK1


ankyrin 1, erythrocytic


chr11_-_47427263 5.064 NM_005055
NM_032645
RAPSN

receptor-associated protein of the synapse

chr15_+_72006015 5.062 LOXL1
lysyl oxidase-like 1
chr2_+_219991342 4.948 NM_001927
DES
desmin
chr15_-_42274760 3.942 FRMD5
FERM domain containing 5
chr9_-_35679799 3.935 TPM2
tropomyosin 2 (beta)
chr15_-_46725087 3.841 NM_000138
FBN1
fibrillin 1
chr9_-_35679902 3.749 NM_003289
NM_213674
TPM2

tropomyosin 2 (beta)

chr2_-_175337386 3.622 NM_000079
NM_001039523
CHRNA1

cholinergic receptor, nicotinic, alpha 1 (muscle)

chr2_-_192767494 3.576 TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr2_+_85834111 3.572 NM_032827
ATOH8
atonal homolog 8 (Drosophila)
chr1_-_143643064 3.464 PDE4DIP
phosphodiesterase 4D interacting protein
chr15_-_23659329 3.457 NM_024490
ATP10A
ATPase, class V, type 10A
chr15_-_42274529 3.337 NM_032892
FRMD5
FERM domain containing 5
chr3_-_87122936 3.251 NM_016206
VGLL3
vestigial like 3 (Drosophila)
chr19_+_58750305 3.251 NM_001079907
ZNF331
zinc finger protein 331
chr2_+_223625105 3.189 NM_080671
KCNE4
potassium voltage-gated channel, Isk-related family, member 4
chr13_+_30378311 3.188 NM_032849
C13orf33
chromosome 13 open reading frame 33
chr1_+_46151845 3.005 MAST2
microtubule associated serine/threonine kinase 2
chr15_+_72005839 2.892 NM_005576
LOXL1
lysyl oxidase-like 1
chr15_+_72005847 2.890 LOXL1
lysyl oxidase-like 1
chr16_+_971808 2.877 NM_014587
SOX8
SRY (sex determining region Y)-box 8
chr4_-_177427252 2.836 NM_080874
ASB5
ankyrin repeat and SOCS box containing 5
chr16_+_972064 2.823 SOX8
SRY (sex determining region Y)-box 8
chr11_-_6298284 2.742 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr19_+_10597167 2.667 NM_020428
SLC44A2
solute carrier family 44, member 2
chr1_-_231498081 2.642 NM_014801
PCNXL2
pecanex-like 2 (Drosophila)
chr22_+_29122932 2.639 NM_012429
NM_033382
SEC14L2

SEC14-like 2 (S. cerevisiae)

chr6_-_33822659 2.633 NM_001142883
NM_054111
IP6K3

inositol hexakisphosphate kinase 3

chr8_-_49996353 2.608 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr7_+_17304707 2.604 NM_001621
AHR
aryl hydrocarbon receptor
chr12_+_79634820 2.603 NM_005593
MYF5
myogenic factor 5
chr4_+_114433551 2.546 ANK2
ankyrin 2, neuronal
chr2_-_217267742 2.535 IGFBP5
insulin-like growth factor binding protein 5
chr18_-_70110089 2.461 NM_001190807
NM_001914
NM_148923
CYB5A


cytochrome b5 type A (microsomal)


chr7_-_45927263 2.425 NM_000598
NM_001013398
IGFBP3

insulin-like growth factor binding protein 3

chr1_+_238321794 2.399 NM_020066
FMN2
formin 2
chr10_-_92670764 2.393 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr16_-_30983909 2.384 NM_001172669
NM_001172670
ZNF668

zinc finger protein 668

chr16_-_52876390 2.379 IRX3
iroquois homeobox 3
chr3_-_39209075 2.365 NM_194293
NM_001198621
XIRP1

xin actin-binding repeat containing 1

chr1_+_148521852 2.341 NM_144697
C1orf51
chromosome 1 open reading frame 51
chr3_-_87122958 2.336 VGLL3
vestigial like 3 (Drosophila)
chr2_+_170074457 2.325 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr10_+_104394185 2.301 NM_030912
TRIM8
tripartite motif containing 8
chrX_+_53095230 2.276 NM_018969
GPR173
G protein-coupled receptor 173
chr2_+_109112428 2.274 NM_001099289
SH3RF3
SH3 domain containing ring finger 3
chr9_-_16717887 2.261 BNC2
basonuclin 2
chr9_+_35782405 2.251 NM_003995
NPR2
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
chr1_-_154205675 2.221 ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr5_-_136862130 2.219 SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr15_-_40537002 2.168 NM_022473
ZFP106
zinc finger protein 106 homolog (mouse)
chr11_+_131286513 2.166 NTM
neurotrimin
chr1_-_153107084 2.164


chr9_+_17568952 2.156 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr9_-_74757735 2.136 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr9_-_135379888 2.131 NM_001080483
TMEM8C
transmembrane protein 8C
chr21_-_38210531 2.130 NM_002240
KCNJ6
potassium inwardly-rectifying channel, subfamily J, member 6
chr8_+_37773991 2.118 GPR124
G protein-coupled receptor 124
chr4_-_165523856 2.116 NM_001166373
MARCH1
membrane-associated ring finger (C3HC4) 1
chr10_+_11100111 2.114 CELF2
CUGBP, Elav-like family member 2
chrX_+_12066505 2.104 NM_014728
FRMPD4
FERM and PDZ domain containing 4
chr14_+_76298693 2.091 VASH1
vasohibin 1
chr9_-_85342868 2.088 NM_174938
FRMD3
FERM domain containing 3
chr4_-_40911212 2.071 NM_001166050
NM_004307
NM_173075
APBB2


amyloid beta (A4) precursor protein-binding, family B, member 2


chr11_-_65395248 2.057 EFEMP2
EGF containing fibulin-like extracellular matrix protein 2
chr1_-_95165089 2.050 NM_001839
CNN3
calponin 3, acidic
chr5_-_136862317 2.044 SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr12_-_29827952 2.044 NM_001193451
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr10_+_11099860 2.042 NM_006561
CELF2
CUGBP, Elav-like family member 2
chr6_+_46205659 2.041 NM_014936
ENPP4
ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
chr15_-_53822468 2.032 NM_173814
PRTG
protogenin
chr7_-_130891861 2.030 NM_001018111
NM_005397
PODXL

podocalyxin-like

chr9_-_96441409 2.024 FBP1
fructose-1,6-bisphosphatase 1
chr10_-_92671005 2.018 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr9_+_129893948 1.978 NM_001006642
SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr10_+_11100075 1.964 CELF2
CUGBP, Elav-like family member 2
chr5_-_176832476 1.963 NM_080881
DBN1
drebrin 1
chr6_-_75972286 1.946 NM_004370
NM_080645
COL12A1

collagen, type XII, alpha 1

chr13_-_25523164 1.938 NM_001007538
SHISA2
shisa homolog 2 (Xenopus laevis)
chr16_+_87765661 1.928 NM_004933
CDH15
cadherin 15, type 1, M-cadherin (myotubule)
chr19_-_50977485 1.905 DMPK
dystrophia myotonica-protein kinase
chr6_-_75972473 1.891 COL12A1
collagen, type XII, alpha 1
chr11_+_126378507 1.885 NCRNA00288
non-protein coding RNA 288
chr17_+_38064787 1.882 NM_016437
TUBG2
tubulin, gamma 2
chr3_+_8750485 1.874 NM_033337
NM_001234
CAV3

caveolin 3

chr6_+_87921980 1.871 NM_015021
ZNF292
zinc finger protein 292
chr8_-_72918697 1.857 MSC
musculin
chr21_+_36993860 1.840 NM_005069
NM_009586
SIM2

single-minded homolog 2 (Drosophila)

chr8_-_16903911 1.837 NM_019851
FGF20
fibroblast growth factor 20
chr2_+_205118961 1.827 PARD3B
par-3 partitioning defective 3 homolog B (C. elegans)
chr2_+_238712101 1.826 NM_198582
KLHL30
kelch-like 30 (Drosophila)
chr6_+_46205777 1.813 ENPP4
ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
chr8_-_72918938 1.805 MSC
musculin
chr5_+_148501178 1.803 NM_014945
ABLIM3
actin binding LIM protein family, member 3
chr17_+_45488330 1.790 NM_002204
NM_005501
ITGA3

integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)

chr8_+_72918772 1.783 LOC100132891
hypothetical LOC100132891
chr4_+_2783764 1.781 SH3BP2
SH3-domain binding protein 2
chr8_-_11096257 1.774 NM_173683
XKR6
XK, Kell blood group complex subunit-related family, member 6
chr8_-_72431274 1.772 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr6_+_137285071 1.770 NM_001008783
SLC35D3
solute carrier family 35, member D3
chr5_-_58370693 1.765 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chr4_+_151218862 1.765 NM_001040260
NM_001040261
DCLK2

doublecortin-like kinase 2

chr4_-_75938710 1.759 NM_001729
BTC
betacellulin
chr8_+_72918889 1.753


chr4_+_54660954 1.746 NM_133267
GSX2
GS homeobox 2
chr1_-_143643324 1.740 NM_001002811
PDE4DIP
phosphodiesterase 4D interacting protein
chr17_+_4922445 1.735 NM_153018
ZFP3
zinc finger protein 3 homolog (mouse)
chr7_-_127458231 1.725 NM_022143
LRRC4
leucine rich repeat containing 4
chr2_+_56265260 1.719


chr1_+_181259317 1.715


chr11_+_118374071 1.704 CCDC84
coiled-coil domain containing 84
chr6_+_129245978 1.700 NM_000426
NM_001079823
LAMA2

laminin, alpha 2

chr17_+_45488356 1.699 ITGA3
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
chr4_+_2783743 1.664 NM_001145855
SH3BP2
SH3-domain binding protein 2
chr2_+_205118801 1.663 PARD3B
par-3 partitioning defective 3 homolog B (C. elegans)
chr1_+_201363458 1.662 NM_000674
NM_001048230
ADORA1

adenosine A1 receptor

chr20_-_22978141 1.642 NM_000361
THBD
thrombomodulin
chr15_-_53996597 1.637 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr10_+_99248605 1.637 NM_024954
UBTD1
ubiquitin domain containing 1
chr17_+_4922478 1.636 ZFP3
zinc finger protein 3 homolog (mouse)
chr3_-_69254226 1.624 NM_198271
LMOD3
leiomodin 3 (fetal)
chr18_-_53621277 1.621 NM_005603
ATP8B1
ATPase, aminophospholipid transporter, class I, type 8B, member 1
chr10_-_99248355 1.621 NM_022362
MMS19
MMS19 nucleotide excision repair homolog (S. cerevisiae)
chr1_+_53300410 1.620 NM_153703
PODN
podocan
chr16_-_63713466 1.606 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr9_+_34980715 1.591 DNAJB5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr16_-_63713485 1.589 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr15_-_66511488 1.581 NM_001004439
ITGA11
integrin, alpha 11
chr10_-_116517945 1.576 ABLIM1
actin binding LIM protein 1
chr17_-_15495534 1.573 TRIM16
tripartite motif containing 16
chr7_+_115953582 1.555 NM_001172896
NM_001172897
CAV1

caveolin 1, caveolae protein, 22kDa

chr8_-_17315171 1.554 MTMR7
myotubularin related protein 7
chr8_-_122722674 1.551 NM_005328
HAS2
hyaluronan synthase 2
chr12_-_47604930 1.539 NM_001143781
FKBP11
FK506 binding protein 11, 19 kDa
chr1_-_199613406 1.535 TNNT2
troponin T type 2 (cardiac)
chr15_+_72005875 1.534 LOXL1
lysyl oxidase-like 1
chr21_+_36429079 1.534 NM_001236
CBR3
carbonyl reductase 3
chr2_+_233099113 1.531 NM_000751
CHRND
cholinergic receptor, nicotinic, delta
chr12_-_78608154 1.528 PAWR
PRKC, apoptosis, WT1, regulator
chr4_+_3341521 1.523 NM_198227
RGS12
regulator of G-protein signaling 12
chr1_-_199613427 1.516 NM_000364
NM_001001430
NM_001001431
NM_001001432
TNNT2



troponin T type 2 (cardiac)



chr2_+_120820140 1.512 NM_002193
INHBB
inhibin, beta B
chr15_+_72005864 1.502 LOXL1
lysyl oxidase-like 1
chr8_+_1909437 1.499 NM_014867
KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr12_-_50871953 1.498 NM_001081492
NM_182507
KRT80

keratin 80

chrX_+_102749489 1.486 NM_001006933
NM_032926
TCEAL3

transcription elongation factor A (SII)-like 3

chr1_-_39871226 1.486 HEYL
hairy/enhancer-of-split related with YRPW motif-like
chr10_-_16604009 1.484 NM_001010908
C1QL3
complement component 1, q subcomponent-like 3
chr5_+_5193442 1.483 NM_139056
ADAMTS16
ADAM metallopeptidase with thrombospondin type 1 motif, 16
chr10_-_102978678 1.480 NM_006562
LBX1
ladybird homeobox 1
chr5_+_159276317 1.473 NM_000679
ADRA1B
adrenergic, alpha-1B-, receptor
chr1_+_15145001 1.463 NM_001017999
KAZN
kazrin, periplakin interacting protein
chr2_+_205118710 1.461 NM_057177
NM_152526
NM_205863
PARD3B


par-3 partitioning defective 3 homolog B (C. elegans)


chr5_+_126654354 1.453 NM_032446
MEGF10
multiple EGF-like-domains 10
chr15_-_68842799 1.452 NM_018003
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr11_-_118799058 1.443 THY1
Thy-1 cell surface antigen
chr8_-_29262240 1.437 NM_057158
DUSP4
dual specificity phosphatase 4
chr16_+_7322751 1.431 NM_145891
NM_145892
NM_145893
RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr21_-_26464790 1.429 APP
amyloid beta (A4) precursor protein
chr7_+_100302885 1.425 NM_003302
TRIP6
thyroid hormone receptor interactor 6
chr2_-_216944911 1.422 NM_020814
MARCH4
membrane-associated ring finger (C3HC4) 4
chr7_+_93862137 1.420 COL1A2
PLAG1
collagen, type I, alpha 2
pleiomorphic adenoma gene 1
chr14_+_76297885 1.406 NM_014909
VASH1
vasohibin 1
chr11_-_62213946 1.400 NM_203422
LRRN4CL
LRRN4 C-terminal like
chr2_-_189752575 1.397 NM_000393
COL5A2
collagen, type V, alpha 2
chr11_-_118739838 1.387 USP2
ubiquitin specific peptidase 2
chr3_+_49034050 1.385 NM_199069
NM_199070
NDUFAF3

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 3

chr9_+_108665168 1.381 NM_021224
ZNF462
zinc finger protein 462
chr3_+_106568334 1.380 NM_001627
ALCAM
activated leukocyte cell adhesion molecule
chr18_+_17076166 1.379 NM_001142966
GREB1L
growth regulation by estrogen in breast cancer-like
chr17_-_8474733 1.371 NM_005964
MYH10
myosin, heavy chain 10, non-muscle
chr11_+_113436438 1.370 NM_001018011
ZBTB16
zinc finger and BTB domain containing 16
chr11_-_118799452 1.366 NM_006288
THY1
Thy-1 cell surface antigen
chr7_+_73145481 1.362 LIMK1
LIM domain kinase 1
chr2_+_238060602 1.356 NM_001042467
NM_024101
MLPH

melanophilin

chr1_-_3556420 1.355 NM_017818
WDR8
WD repeat domain 8
chr9_-_25668230 1.354 TUSC1
tumor suppressor candidate 1
chr12_-_107745455 1.353 NM_001161331
SSH1
slingshot homolog 1 (Drosophila)
chr2_+_149603226 1.348 NM_177964
LYPD6B
LY6/PLAUR domain containing 6B
chr1_+_54786394 1.346 NM_015547
NM_147161
ACOT11

acyl-CoA thioesterase 11

chr17_+_1905104 1.341 NM_006497
HIC1
hypermethylated in cancer 1
chr10_+_116843108 1.341 NM_207303
ATRNL1
attractin-like 1
chr11_+_118374051 1.339 NM_198489
CCDC84
coiled-coil domain containing 84
chr3_+_106568243 1.327 ALCAM
activated leukocyte cell adhesion molecule
chr16_-_63713382 1.321 NM_001797
CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr7_-_27162688 1.318 NM_006896
HOXA7
homeobox A7
chr3_+_106568430 1.317 ALCAM
activated leukocyte cell adhesion molecule
chr11_-_1725924 1.314 NM_001170820
LOC402778
CD225 family protein FLJ76511
chr15_+_66658626 1.311 NM_006091
CORO2B
coronin, actin binding protein, 2B
chr17_-_4216359 1.311 UBE2G1
ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)
chr14_+_101500520 1.311 NM_001376
DYNC1H1
dynein, cytoplasmic 1, heavy chain 1
chr1_-_40140126 1.303 NM_001033081
NM_001033082
NM_005376
MYCL1


v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)


chr5_-_178704934 1.287 ADAMTS2
ADAM metallopeptidase with thrombospondin type 1 motif, 2
chr4_+_185063421 1.284 NM_020225
STOX2
storkhead box 2
chr15_-_58671929 1.284 NM_134262
RORA
RAR-related orphan receptor A
chr7_+_140420500 1.282 NM_001195278
LOC100131199
transmembrane protein 178-like
chr3_-_185025989 1.280 NM_024871
MAP6D1
MAP6 domain containing 1
chr6_-_46566969 1.270 RCAN2
regulator of calcineurin 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.28 1.26e-07 GO:0007399 nervous system development
1.18 7.79e-07 GO:0048731 system development
1.16 1.30e-06 GO:0007275 multicellular organismal development
1.17 1.98e-06 GO:0048856 anatomical structure development
1.15 6.02e-06 GO:0032502 developmental process
1.09 7.84e-05 GO:0050794 regulation of cellular process
1.23 1.01e-04 GO:0009653 anatomical structure morphogenesis
1.19 1.02e-04 GO:0030154 cell differentiation
1.30 1.55e-04 GO:0022008 neurogenesis
1.35 1.84e-04 GO:0007167 enzyme linked receptor protein signaling pathway
1.19 2.78e-04 GO:0048869 cellular developmental process
1.64 3.49e-04 GO:0007517 muscle organ development
1.08 4.44e-04 GO:0050789 regulation of biological process
1.08 4.62e-04 GO:0065007 biological regulation
1.52 6.62e-04 GO:0061061 muscle structure development
1.21 6.63e-04 GO:0023051 regulation of signaling
1.18 7.37e-04 GO:0048523 negative regulation of cellular process
1.49 8.68e-04 GO:0022603 regulation of anatomical structure morphogenesis
1.19 1.17e-03 GO:0007166 cell surface receptor linked signaling pathway
1.16 1.22e-03 GO:0048519 negative regulation of biological process
1.28 1.44e-03 GO:0048699 generation of neurons
1.25 2.10e-03 GO:0010646 regulation of cell communication
1.27 2.53e-03 GO:0048468 cell development
1.21 2.56e-03 GO:0009966 regulation of signal transduction
1.15 4.69e-03 GO:0048522 positive regulation of cellular process
1.22 5.08e-03 GO:0051239 regulation of multicellular organismal process
1.14 5.15e-03 GO:0048518 positive regulation of biological process
1.37 5.17e-03 GO:0072358 cardiovascular system development
1.37 5.17e-03 GO:0072359 circulatory system development
1.29 9.52e-03 GO:0030182 neuron differentiation
1.11 9.71e-03 GO:0023052 signaling
1.24 1.37e-02 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.34 1.53e-02 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
2.32 1.95e-02 GO:0051153 regulation of striated muscle cell differentiation
1.27 2.58e-02 GO:2000026 regulation of multicellular organismal development
1.31 2.96e-02 GO:0048666 neuron development
1.12 3.01e-02 GO:0007165 signal transduction
1.41 3.60e-02 GO:0060284 regulation of cell development
1.29 4.42e-02 GO:0032989 cellular component morphogenesis
1.40 4.78e-02 GO:0007411 axon guidance

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.94 7.52e-07 GO:0044449 contractile fiber part
1.89 9.36e-07 GO:0043292 contractile fiber
1.92 1.02e-06 GO:0030016 myofibril
1.92 1.70e-05 GO:0030017 sarcomere
1.45 3.85e-05 GO:0031012 extracellular matrix
1.46 2.58e-04 GO:0005578 proteinaceous extracellular matrix
1.43 3.30e-03 GO:0015629 actin cytoskeleton
1.06 3.91e-03 GO:0005737 cytoplasm
1.77 4.98e-03 GO:0001726 ruffle
1.34 1.36e-02 GO:0043005 neuron projection
2.18 3.02e-02 GO:0042641 actomyosin
1.04 3.58e-02 GO:0005622 intracellular
1.52 4.52e-02 GO:0005912 adherens junction
2.09 4.88e-02 GO:0005581 collagen

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.35 6.21e-04 GO:0008092 cytoskeletal protein binding
1.07 2.73e-03 GO:0005515 protein binding
1.41 4.71e-03 GO:0003779 actin binding
1.80 1.41e-02 GO:0005201 extracellular matrix structural constituent