Motif ID: HNF1A.p2

Z-value: 5.593


Transcription factors associated with HNF1A.p2:

Gene SymbolEntrez IDGene Name
HNF1A 6927 HNF1 homeobox A



Activity profile for motif HNF1A.p2.

activity profile for motif HNF1A.p2


Sorted Z-values histogram for motif HNF1A.p2

Sorted Z-values for motif HNF1A.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF1A.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_40995564 41.642 PRODH2
proline dehydrogenase (oxidase) 2
chr19_-_40995606 39.874 PRODH2
proline dehydrogenase (oxidase) 2
chr6_-_24491498 36.189 NM_001195610
DCDC2
doublecortin domain containing 2
chr20_+_42417752 33.328 NM_001030003
NM_001030004
NM_175914
HNF4A


hepatocyte nuclear factor 4, alpha


chr7_-_44547382 31.205 NM_001101648
NM_013389
NPC1L1

NPC1 (Niemann-Pick disease, type C1, gene)-like 1

chr5_+_175908948 29.899 NM_017675
CDHR2
cadherin-related family member 2
chr11_-_117200618 29.279 NM_001127489
NM_001680
FXYD2

FXYD domain containing ion transport regulator 2

chr20_+_42463419 29.253 HNF4A
hepatocyte nuclear factor 4, alpha
chr16_-_86527608 29.104 NM_001739
CA5A
carbonic anhydrase VA, mitochondrial
chr20_+_42417502 28.976 HNF4A
hepatocyte nuclear factor 4, alpha
chrX_-_105169370 28.957 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr1_+_17779528 27.976 NM_001011722
ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr14_-_93924663 27.932 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr20_+_41621119 27.829 SGK2
serum/glucocorticoid regulated kinase 2
chr7_-_47545717 27.745 NM_022748
TNS3
tensin 3
chr20_+_41621079 27.372 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr1_+_48460943 27.198 NM_001011547
NM_001135181
SLC5A9

solute carrier family 5 (sodium/glucose cotransporter), member 9

chr20_+_42463387 27.025 HNF4A
hepatocyte nuclear factor 4, alpha
chr7_-_50600536 26.505 NM_001082971
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr20_+_42463350 26.259 HNF4A
hepatocyte nuclear factor 4, alpha
chr21_-_46399900 26.193 NM_006657
NM_206965
FTCD

formiminotransferase cyclodeaminase

chr12_-_15757114 25.642 EPS8
epidermal growth factor receptor pathway substrate 8
chr19_+_11211282 25.518 NM_018687
LOC55908
hepatocellular carcinoma-associated gene TD26
chr4_-_977163 25.288 NM_022042
NM_134425
NM_213613
SLC26A1


solute carrier family 26 (sulfate transporter), member 1


chr17_-_61655915 24.465 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr14_-_93859394 24.300 NM_001756
SERPINA6
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
chr20_+_42463279 23.489 NM_000457
NM_178849
NM_178850
HNF4A


hepatocyte nuclear factor 4, alpha


chr14_+_38772870 23.436 NM_054024
MIA2
melanoma inhibitory activity 2
chr9_-_122852356 23.285 NM_001735
C5
complement component 5
chr14_-_93924873 23.105 NM_000295
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr17_+_71065478 23.032 LLGL2
lethal giant larvae homolog 2 (Drosophila)
chr14_-_93829113 22.598 NM_016186
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr2_+_27573206 22.295 NM_001486
GCKR
glucokinase (hexokinase 4) regulator
chr14_+_94097513 21.803 NM_006215
SERPINA4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
chr14_-_93829309 21.686 SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr8_+_21967008 21.351 NM_001114137
EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr14_-_93829347 20.959 NM_001100607
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr17_+_38306339 20.394 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr10_+_99334411 20.080 HOGA1
4-hydroxy-2-oxoglutarate aldolase 1
chr4_+_74520796 20.077 NM_001134
AFP
alpha-fetoprotein
chr14_+_20226762 20.009 NM_001097577
NM_194431
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr4_-_155731288 19.891 NM_000508
NM_021871
FGA

fibrinogen alpha chain

chr15_+_56511466 19.558 NM_000236
LIPC
lipase, hepatic
chr2_-_88208650 19.000 NM_001443
FABP1
fatty acid binding protein 1, liver
chr6_+_31731667 18.663 APOM
apolipoprotein M
chr11_+_46697345 18.581 F2
coagulation factor II (thrombin)
chr16_+_21152516 18.528 NM_145865
ANKS4B
ankyrin repeat and sterile alpha motif domain containing 4B
chr17_+_71154240 18.459 NM_001162997
LOC100130933
hypothetical protein LOC100130933
chr16_-_67943157 18.240 NM_144676
TMED6
transmembrane emp24 protein transport domain containing 6
chr4_+_74566325 18.053 NM_001133
AFM
afamin
chr6_+_31731647 17.587 NM_019101
APOM
apolipoprotein M
chrX_+_70351812 16.960 GJB1
gap junction protein, beta 1, 32kDa
chr11_+_46697335 16.925 F2
coagulation factor II (thrombin)
chr10_+_99334069 16.650 NM_001134670
NM_138413
HOGA1

4-hydroxy-2-oxoglutarate aldolase 1

chr4_-_186970366 16.626 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr11_+_46697312 16.610 NM_000506
F2
coagulation factor II (thrombin)
chr6_-_116488458 16.560 NM_002031
FRK
fyn-related kinase
chr19_-_53081326 16.546 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr7_+_45894480 16.542 NM_000596
IGFBP1
insulin-like growth factor binding protein 1
chr4_+_74488947 16.346 ALB
albumin
chr4_+_3413489 16.244 NM_001528
HGFAC
HGF activator
chr16_-_46826588 16.192 NM_032583
NM_145186
ABCC11

ATP-binding cassette, sub-family C (CFTR/MRP), member 11

chr11_-_64582568 16.167 NM_005468
NAALADL1
N-acetylated alpha-linked acidic dipeptidase-like 1
chr1_+_93830106 16.127 LOC100129046
hypothetical LOC100129046
chr12_+_54910767 16.122 NM_001135195
SLC39A5
solute carrier family 39 (metal ion transporter), member 5
chr4_-_100359353 16.045 NM_000672
NM_001102470
ADH6

alcohol dehydrogenase 6 (class V)

chr22_-_36836478 15.971 BAIAP2L2
BAI1-associated protein 2-like 2
chrX_+_70351773 15.961 NM_001097642
GJB1
gap junction protein, beta 1, 32kDa
chr4_+_3413457 15.804 HGFAC
HGF activator
chr4_+_74488910 15.755 ALB
albumin
chr10_+_101532450 15.590 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr4_+_74488835 15.531 NM_000477
ALB
albumin
chr1_+_18680010 15.465 NM_152375
KLHDC7A
kelch domain containing 7A
chr22_-_36836620 15.332 NM_025045
BAIAP2L2
BAI1-associated protein 2-like 2
chr19_-_53081383 15.296 NM_003167
SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr4_-_110942576 15.098 CFI
complement factor I
chr4_-_69852090 15.095 NM_024743
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr8_-_17797127 14.832 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr11_+_64079665 14.578 NM_018484
SLC22A11
solute carrier family 22 (organic anion/urate transporter), member 11
chr6_+_64289585 14.387 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr19_-_63556632 14.062 NM_130786
A1BG
alpha-1-B glycoprotein
chr4_+_187424111 14.054 NM_000128
F11
coagulation factor XI
chr1_+_93830169 13.946 LOC100129046
hypothetical LOC100129046
chr15_-_88150823 13.759 ANPEP
alanyl (membrane) aminopeptidase
chr5_-_138746917 13.479 NM_005847
NM_152685
SLC23A1

solute carrier family 23 (nucleobase transporters), member 1

chr5_-_138746840 13.337 SLC23A1
solute carrier family 23 (nucleobase transporters), member 1
chr10_-_52315390 13.303 A1CF
APOBEC1 complementation factor
chr10_-_52315436 12.911 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr1_-_20014180 12.894 NM_019062
RNF186
ring finger protein 186
chr1_-_202449659 12.836 NM_198447
GOLT1A
golgi transport 1A
chr17_+_1592879 12.793 NM_000934
NM_001165921
SERPINF2

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2

chr5_+_73145098 12.681 RGNEF
190 kDa guanine nucleotide exchange factor
chr10_+_114144512 12.288 ACSL5
acyl-CoA synthetase long-chain family member 5
chr4_+_74497998 12.062 ALB
albumin
chr10_+_44726635 11.861 NM_001123376
TMEM72
transmembrane protein 72
chr17_-_202557 11.569 RPH3AL
rabphilin 3A-like (without C2 domains)
chr1_-_204455269 11.435 NM_001007544
C1orf186
chromosome 1 open reading frame 186
chr10_-_101680645 11.410 DNMBP
dynamin binding protein
chr19_-_38052481 11.267 NM_001126335
NM_014270
SLC7A9

solute carrier family 7 (cationic amino acid transporter, y+ system), member 9

chr10_+_101532544 11.143 ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr4_+_155703581 11.079 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr4_-_110942783 11.007 NM_000204
CFI
complement factor I
chr17_+_1592893 10.899 SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr4_+_74498042 10.563 ALB
albumin
chr6_+_167624792 10.378 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr17_-_202617 9.200 NM_001190411
NM_001190412
NM_001190413
NM_006987
RPH3AL



rabphilin 3A-like (without C2 domains)



chr17_+_4638966 9.122 NM_001014985
GLTPD2
glycolipid transfer protein domain containing 2
chr6_+_167456230 8.777 NM_031409
CCR6
chemokine (C-C motif) receptor 6
chr8_+_76482661 8.369 HNF4G
hepatocyte nuclear factor 4, gamma
chr4_+_187424336 8.286 F11
coagulation factor XI
chr19_-_40996040 8.143 NM_021232
PRODH2
proline dehydrogenase (oxidase) 2
chr3_+_185430910 8.016 NM_138345
VWA5B2
von Willebrand factor A domain containing 5B2
chr17_+_1586034 7.999 WDR81
WD repeat domain 81
chr17_+_1593040 7.962 NM_001165920
SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr18_+_27425727 7.639 NM_000371
TTR
transthyretin
chr16_-_65510230 7.507 NM_004062
CDH16
cadherin 16, KSP-cadherin
chr12_+_119900677 7.334 HNF1A
HNF1 homeobox A
chr14_+_87560646 7.288 LOC283587
hypothetical protein LOC283587
chr7_-_156494741 7.126 NM_001165255
MNX1
motor neuron and pancreas homeobox 1
chr16_+_88224276 6.994 DPEP1
dipeptidase 1 (renal)
chr20_+_61841553 6.706 NM_020062
SLC2A4RG
SLC2A4 regulator
chr6_-_52060327 6.624 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr11_-_62539857 6.530 NM_001184732
NM_001184733
NM_001184736
NM_004254
SLC22A8



solute carrier family 22 (organic anion transporter), member 8



chr14_-_57030227 6.512 NM_018168
C14orf105
chromosome 14 open reading frame 105
chr20_+_35406497 6.485 NM_005417
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr6_-_26038817 6.455 NM_005835
SLC17A2
solute carrier family 17 (sodium phosphate), member 2
chr5_+_140509803 6.262 NM_018939
PCDHB6
protocadherin beta 6
chr1_+_205328834 6.194 NM_001017365
NM_001017366
C4BPB

complement component 4 binding protein, beta

chr20_-_43972061 6.192 PLTP
phospholipid transfer protein
chr1_+_205344200 6.115 NM_000715
C4BPA
complement component 4 binding protein, alpha
chr3_+_63928459 5.866 NM_001128149
ATXN7
ataxin 7
chr3_+_150675117 5.559 NM_004617
TM4SF4
transmembrane 4 L six family member 4
chr1_-_228916559 5.493 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr10_+_5126613 5.308 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr2_+_101981888 5.270 NM_173343
IL1R2
interleukin 1 receptor, type II
chrX_-_107569256 5.232 NM_001847
COL4A6
collagen, type IV, alpha 6
chr16_+_88224175 5.232 DPEP1
dipeptidase 1 (renal)
chrX_-_131375217 5.193 NM_001170701
NM_001170702
NM_001170703
MBNL3


muscleblind-like 3 (Drosophila)


chr1_-_42402973 5.180 NM_033553
GUCA2A
guanylate cyclase activator 2A (guanylin)
chr2_-_101370355 4.938 NM_153836
CREG2
cellular repressor of E1A-stimulated genes 2
chr7_+_139175420 4.741 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr4_+_69996780 4.603 NM_001074
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr8_-_124818754 4.566 NM_001003954
NM_004306
ANXA13

annexin A13

chr4_+_154345039 4.543 NM_015271
TRIM2
tripartite motif containing 2
chr16_-_56393871 4.394 KIFC3
kinesin family member C3
chr10_+_5126556 4.385 NM_003739
AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr16_-_56389176 4.378 NM_001130099
KIFC3
kinesin family member C3
chr10_+_5126589 4.197 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr15_-_96875133 4.189 NM_182562
FAM169B
family with sequence similarity 169, member B
chr11_-_118405288 4.120 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr4_+_74493918 4.004 ALB
albumin
chr4_-_40211324 3.916 RBM47
RNA binding motif protein 47
chr6_+_126112417 3.911 NM_012259
HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr6_+_161043214 3.857 NM_000301
NM_001168338
PLG

plasminogen

chr3_+_150675169 3.857 TM4SF4
transmembrane 4 L six family member 4
chr19_+_46201665 3.783 CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr14_+_38805251 3.744 NM_203356
CTAGE5
CTAGE family, member 5
chr3_-_25654659 3.515 TOP2B
topoisomerase (DNA) II beta 180kDa
chr6_-_31789824 3.510


chr20_-_7869068 3.487 NM_017545
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr1_-_195302973 3.450 NM_001994
F13B
coagulation factor XIII, B polypeptide
chr9_-_33385265 3.449 AQP7
aquaporin 7
chr7_+_94953148 3.359 NM_016116
NM_145872
ASB4

ankyrin repeat and SOCS box containing 4

chr10_+_111755715 3.338 NM_019903
ADD3
adducin 3 (gamma)
chr16_+_30118036 3.324 NM_001017390
NM_177552
SULT1A4
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr9_+_129900637 3.320 NM_052901
NM_001006643
SLC25A25

solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25

chr17_+_65009986 3.308 MAP2K6
mitogen-activated protein kinase kinase 6
chr9_+_129900590 3.305 SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr19_+_50109416 3.284 APOC1
apolipoprotein C-I
chr6_+_126112431 3.279 HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr12_+_119900931 3.269 NM_000545
HNF1A
HNF1 homeobox A
chr13_-_99983945 3.211 NM_033110
A2LD1
AIG2-like domain 1
chr6_+_126112506 3.138 HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr22_-_41685827 3.075 NM_001184971
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr2_-_63518589 3.055 NM_001042692
WDPCP
WD repeat containing planar cell polarity effector
chr12_+_91620749 2.904 NM_001037671
NM_001178097
C12orf74

chromosome 12 open reading frame 74

chr2_-_168812132 2.904 NM_013233
STK39
serine threonine kinase 39
chr16_+_56286212 2.896 NM_032269
CCDC135
coiled-coil domain containing 135
chr9_-_116305273 2.882 NM_001083885
DFNB31
deafness, autosomal recessive 31
chr2_-_162638790 2.857 DPP4
dipeptidyl-peptidase 4
chr2_-_162639297 2.848 NM_001935
DPP4
dipeptidyl-peptidase 4
chr1_-_228916486 2.832 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr2_+_101874765 2.827 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr2_+_101874809 2.746 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr9_-_115901157 2.711 NM_138424
KIF12
kinesin family member 12
chr20_+_55569542 2.642 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr2_+_62787534 2.609 NM_001142614
EHBP1
EH domain binding protein 1
chr6_-_52736231 2.566 NM_000846
GSTA2
glutathione S-transferase alpha 2
chr17_+_56832255 2.539 TBX2
T-box 2
chr1_-_228916470 2.521 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr6_+_54281161 2.488 NM_014464
TINAG
tubulointerstitial nephritis antigen
chr7_+_99263571 2.479 NM_022820
NM_057095
NM_057096
CYP3A43


cytochrome P450, family 3, subfamily A, polypeptide 43


chr1_-_36562341 2.431 NM_018166
FAM176B
family with sequence similarity 176, member B
chr1_+_20353284 2.388


chr2_+_97696462 2.369 NM_001079
ZAP70
zeta-chain (TCR) associated protein kinase 70kDa
chr12_+_50342814 2.309 NM_001177984
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr6_+_25862905 2.291 NM_005495
SLC17A4
solute carrier family 17 (sodium phosphate), member 4
chr9_+_130257254 2.284 NM_153436
ODF2
outer dense fiber of sperm tails 2
chr4_-_159312973 2.262 FAM198B
family with sequence similarity 198, member B
chr3_+_120799411 2.243 NM_015900
PLA1A
phospholipase A1 member A

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
7.12 1.09e-06 GO:0006805 xenobiotic metabolic process
7.12 1.09e-06 GO:0071466 cellular response to xenobiotic stimulus
7.06 1.22e-06 GO:0009410 response to xenobiotic stimulus
3.01 2.14e-05 GO:0006082 organic acid metabolic process
1.89 3.20e-04 GO:0042221 response to chemical stimulus
3.45 3.25e-04 GO:0071702 organic substance transport
14.78 3.91e-04 GO:0030195 negative regulation of blood coagulation
14.27 5.08e-04 GO:0050819 negative regulation of coagulation
26.87 6.91e-04 GO:0046415 urate metabolic process
24.63 1.17e-03 GO:0051917 regulation of fibrinolysis
4.30 1.34e-03 GO:0008202 steroid metabolic process
2.65 2.28e-03 GO:0042180 cellular ketone metabolic process
2.37 2.40e-03 GO:0006629 lipid metabolic process
10.61 4.33e-03 GO:0030193 regulation of blood coagulation
2.61 4.47e-03 GO:0019752 carboxylic acid metabolic process
2.61 4.47e-03 GO:0043436 oxoacid metabolic process
10.35 5.17e-03 GO:0030301 cholesterol transport
10.10 6.15e-03 GO:0015918 sterol transport
29.56 6.46e-03 GO:0009750 response to fructose stimulus
9.86 7.27e-03 GO:0050818 regulation of coagulation
7.76 1.00e-02 GO:0010951 negative regulation of endopeptidase activity
26.28 1.15e-02 GO:0009812 flavonoid metabolic process
26.28 1.15e-02 GO:0051918 negative regulation of fibrinolysis
15.56 1.56e-02 GO:0034381 plasma lipoprotein particle clearance
3.38 1.65e-02 GO:0032787 monocarboxylic acid metabolic process
8.62 1.82e-02 GO:0061041 regulation of wound healing
44.34 2.30e-02 GO:0015712 hexose phosphate transport
44.34 2.30e-02 GO:0015760 glucose-6-phosphate transport
4.38 2.50e-02 GO:0015849 organic acid transport
1.74 2.54e-02 GO:0065008 regulation of biological quality
10.14 2.90e-02 GO:0097006 regulation of plasma lipoprotein particle levels
21.50 2.93e-02 GO:0009698 phenylpropanoid metabolic process
1.81 3.04e-02 GO:0044281 small molecule metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
6.69 1.35e-08 GO:0016324 apical plasma membrane
5.89 1.50e-08 GO:0045177 apical part of cell
2.62 5.63e-05 GO:0005624 membrane fraction
2.33 7.07e-05 GO:0000267 cell fraction
2.54 1.18e-04 GO:0005626 insoluble fraction
9.10 4.75e-04 GO:0031983 vesicle lumen
2.44 9.07e-04 GO:0005615 extracellular space
8.16 1.11e-03 GO:0031091 platelet alpha granule
8.81 2.57e-03 GO:0031093 platelet alpha granule lumen
8.62 2.97e-03 GO:0034774 secretory granule lumen
8.28 3.91e-03 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
2.12 4.30e-03 GO:0044421 extracellular region part
2.39 7.51e-03 GO:0005789 endoplasmic reticulum membrane
2.30 7.86e-03 GO:0044432 endoplasmic reticulum part
2.34 1.10e-02 GO:0042175 nuclear membrane-endoplasmic reticulum network
7.89 2.06e-02 GO:0005903 brush border
1.66 2.64e-02 GO:0005576 extracellular region
1.96 2.78e-02 GO:0005783 endoplasmic reticulum
25.34 3.16e-02 GO:0005577 fibrinogen complex
25.34 3.16e-02 GO:0046581 intercellular canaliculus
1.62 3.28e-02 GO:0044459 plasma membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
12.67 1.85e-03 GO:0015020 glucuronosyltransferase activity
6.05 5.36e-03 GO:0004867 serine-type endopeptidase inhibitor activity
3.46 5.53e-03 GO:0004857 enzyme inhibitor activity
4.43 1.25e-02 GO:0004866 endopeptidase inhibitor activity
2.12 1.57e-02 GO:0030234 enzyme regulator activity
4.31 1.60e-02 GO:0031406 carboxylic acid binding
7.14 1.60e-02 GO:0033293 monocarboxylic acid binding
4.25 1.80e-02 GO:0061135 endopeptidase regulator activity
4.20 2.03e-02 GO:0030414 peptidase inhibitor activity
8.06 2.76e-02 GO:0043498 cell surface binding
15.77 2.85e-02 GO:0008514 organic anion transmembrane transporter activity
2.62 4.10e-02 GO:0008289 lipid binding
25.34 4.81e-02 GO:0005436 sodium:phosphate symporter activity