• All motifs sorted by activity significance
• All samples sorted alphabetically
• Mean activities

• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
• Download the whole report

Motif ID: ATF6.p2

Z-value: 1.330

---

Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr3_-_73756668	2.088	NM_015009	PDZRN3	PDZ domain containing ring finger 3
chr7_+_27191534	1.911		HOXA11-AS1	HOXA11 antisense RNA 1 (non-protein coding)
chr19_+_54723044	1.850		RCN3	reticulocalbin 3, EF-hand calcium binding domain
chr2_-_192767494	1.777		TMEFF2	transmembrane protein with EGF-like and two follistatin-like domains 2
chr2_-_192767844	1.616	NM_016192	TMEFF2	transmembrane protein with EGF-like and two follistatin-like domains 2
chr7_-_27191287	1.549	NM_005523	HOXA11	homeobox A11
chr10_-_118022965	1.535	NM_005264	GFRA1	GDNF family receptor alpha 1
chr15_-_66511488	1.513	NM_001004439	ITGA11	integrin, alpha 11
chr4_-_187884721	1.421
chr4_+_166519392	1.396	NM_001873	CPE	carboxypeptidase E
chr14_+_100362204	1.330		MEG3	maternally expressed 3 (non-protein coding)
chr7_-_19123765	1.302		TWIST1	twist homolog 1 (Drosophila)
chr4_-_186693574	1.279	NM_001114107 NM_014476	PDLIM3	PDZ and LIM domain 3
chr17_-_13445942	1.273	NM_006042	HS3ST3A1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
chr7_-_19123787	1.266	NM_000474	TWIST1	twist homolog 1 (Drosophila)
chr6_+_1336077	1.263
chr16_-_78192111	1.216	NM_001031804 NM_005360	MAF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)
chr1_-_16355013	1.179	NM_004431	EPHA2	EPH receptor A2
chr12_-_123568781	1.174
chr4_-_100069303	1.172		EIF4E	eukaryotic translation initiation factor 4E
chrX_+_100692071	1.152	NM_016608	ARMCX1	armadillo repeat containing, X-linked 1
chrX_-_34585287	1.138	NM_031442	TMEM47	transmembrane protein 47
chr2_-_133144094	1.106		LYPD1	LY6/PLAUR domain containing 1
chr4_-_100069265	1.103	NM_001130678	EIF4E	eukaryotic translation initiation factor 4E
chr12_+_20413445	1.085	NM_000921	PDE3A	phosphodiesterase 3A, cGMP-inhibited
chr9_-_78710698	1.061	NM_015225	PRUNE2	prune homolog 2 (Drosophila)
chr7_+_128257698	1.040	NM_001127487 NM_001458	FLNC	filamin C, gamma
chr14_+_100362236	1.034		MEG3	maternally expressed 3 (non-protein coding)
chr12_-_113328271	1.033	NM_181486	TBX5	T-box 5
chr9_+_35528890	1.026		RUSC2	RUN and SH3 domain containing 2
chr5_+_80292313	1.014	NM_006909	RASGRF2	Ras protein-specific guanine nucleotide-releasing factor 2
chr7_+_93861808	1.012	NM_000089	COL1A2	collagen, type I, alpha 2
chr1_-_239587090	0.992	NM_002924	RGS7	regulator of G-protein signaling 7
chr5_-_37875538	0.985	NM_000514	GDNF	glial cell derived neurotrophic factor
chr1_-_239587007	0.978		RGS7	regulator of G-protein signaling 7
chr10_-_131652364	0.977		EBF3	early B-cell factor 3
chrX_-_100801472	0.964	NM_014782 NM_177949	ARMCX2	armadillo repeat containing, X-linked 2
chr22_-_42589543	0.957	NM_014351	SULT4A1	sulfotransferase family 4A, member 1
chr9_+_35528628	0.936	NM_001135999	RUSC2	RUN and SH3 domain containing 2
chr17_-_44042924	0.933		HOXB7	homeobox B7
chr14_+_22375753	0.924		MMP14	matrix metallopeptidase 14 (membrane-inserted)
chr14_+_22375632	0.918	NM_004995	MMP14	matrix metallopeptidase 14 (membrane-inserted)
chr1_-_202595666	0.916	NM_014935	PLEKHA6	pleckstrin homology domain containing, family A member 6
chr20_-_4177519	0.916	NM_000678	ADRA1D	adrenergic, alpha-1D-, receptor
chr6_-_128883125	0.907	NM_002844 NM_001135648	PTPRK	protein tyrosine phosphatase, receptor type, K
chr4_-_24523605	0.900	NM_001130726	CCDC149	coiled-coil domain containing 149
chr18_+_7557313	0.892	NM_001105244 NM_002845	PTPRM	protein tyrosine phosphatase, receptor type, M
chr5_+_80292213	0.880		RASGRF2	Ras protein-specific guanine nucleotide-releasing factor 2
chr14_+_22375656	0.880		MMP14	matrix metallopeptidase 14 (membrane-inserted)
chr17_-_44043278	0.874		HOXB7	homeobox B7
chr14_+_22375747	0.873		MMP14	matrix metallopeptidase 14 (membrane-inserted)
chr8_+_106400322	0.870	NM_012082	ZFPM2	zinc finger protein, multitype 2
chr17_-_44043361	0.865	NM_004502	HOXB7	homeobox B7
chr22_+_37193961	0.860	NM_006855 NM_016657	KDELR3	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
chr17_+_56884560	0.855		TBX4	T-box 4
chr4_-_111763356	0.855		PITX2	paired-like homeodomain 2
chr6_+_151602787	0.853	NM_005100	AKAP12	A kinase (PRKA) anchor protein 12
chr5_+_170221584	0.852	NM_022897	RANBP17	RAN binding protein 17
chr19_-_52710129	0.843	NM_003827	NAPA	N-ethylmaleimide-sensitive factor attachment protein, alpha
chr2_+_10969513	0.840	NM_002236	KCNF1	potassium voltage-gated channel, subfamily F, member 1
chr2_-_198248828	0.839	NM_144629	RFTN2	raftlin family member 2
chr6_-_75972473	0.837		COL12A1	collagen, type XII, alpha 1
chr13_-_20533629	0.837		LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)
chr15_-_53668341	0.829	NM_015617	PYGO1	pygopus homolog 1 (Drosophila)
chr9_-_130749604	0.828	NM_014908	DOLK	dolichol kinase
chr7_-_6490375	0.790		KDELR2	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
chr4_-_111763655	0.787	NM_000325	PITX2	paired-like homeodomain 2
chr7_+_28415495	0.783		LOC401317	hypothetical LOC401317
chr19_+_18584666	0.780	NM_012109	TMEM59L	transmembrane protein 59-like
chr16_+_15435825	0.776	NM_033201	C16orf45	chromosome 16 open reading frame 45
chr16_-_52877868	0.773	NM_024336	IRX3	iroquois homeobox 3
chr2_-_236741352	0.754	NM_001485	GBX2	gastrulation brain homeobox 2
chr14_-_22891865	0.753	NM_016609	SLC22A17	solute carrier family 22, member 17
chr16_-_69277355	0.742	NM_138383	MTSS1L	metastasis suppressor 1-like
chr7_-_35260213	0.738	NM_001077653 NM_001166220	TBX20	T-box 20
chr19_-_52709975	0.714		NAPA	N-ethylmaleimide-sensitive factor attachment protein, alpha
chr6_-_80713589	0.711	NM_022726	ELOVL4	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4
chr7_-_45095017	0.707	NM_001146334	NACAD	NAC alpha domain containing
chr19_+_54149941	0.702		BAX	BCL2-associated X protein
chr16_-_52877829	0.700		IRX3	iroquois homeobox 3
chrX_+_102749489	0.687	NM_001006933 NM_032926	TCEAL3	transcription elongation factor A (SII)-like 3
chr9_-_89779413	0.687	NM_001039803 NM_001170639 NM_001170640 NM_012119 NM_178432	CDK20	cyclin-dependent kinase 20
chr10_-_128067062	0.685	NM_003474 NM_021641	ADAM12	ADAM metallopeptidase domain 12
chr12_+_6768960	0.673		CD4	CD4 molecule
chr5_+_170221441	0.672		RANBP17	RAN binding protein 17
chr19_+_54149963	0.671		BAX	BCL2-associated X protein
chr12_+_6768934	0.663	NM_001195014 NM_001195015 NM_001195016 NM_001195017	CD4	CD4 molecule
chr19_-_52710089	0.659		NAPA	N-ethylmaleimide-sensitive factor attachment protein, alpha
chr11_-_35503720	0.659	NM_001001991 NM_015430	PAMR1	peptidase domain containing associated with muscle regeneration 1
chr21_+_37367432	0.655	NM_001001894	TTC3	tetratricopeptide repeat domain 3
chr8_-_38245694	0.651	NM_001102559 NM_001102560 NM_032483	PPAPDC1B	phosphatidic acid phosphatase type 2 domain containing 1B
chr11_-_75599433	0.650		WNT11	wingless-type MMTV integration site family, member 11
chr12_+_70120028	0.648	NM_003667	LGR5	leucine-rich repeat containing G protein-coupled receptor 5
chr3_+_148609841	0.648	NM_003412	ZIC1	Zic family member 1 (odd-paired homolog, Drosophila)
chr13_-_35818777	0.642	NM_001142295	SPG20	spastic paraplegia 20 (Troyer syndrome)
chr3_-_24511180	0.640	NM_001128176 NM_000461 NM_001128177	THRB	thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
chr17_-_77824849	0.634	NM_001893 NM_139062	CSNK1D	casein kinase 1, delta
chr9_+_35896188	0.630	NM_001039792	HRCT1	histidine rich carboxyl terminus 1
chr11_+_113435506	0.627		ZBTB16	zinc finger and BTB domain containing 16
chr6_+_144649142	0.623		UTRN	utrophin
chr9_+_130749791	0.620	NM_015354	NUP188	nucleoporin 188kDa
chr8_+_22479115	0.618	NM_001018003	SORBS3	sorbin and SH3 domain containing 3
chr11_-_118739838	0.618		USP2	ubiquitin specific peptidase 2
chr8_-_93184629	0.613	NM_001198633 NM_175634	RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr6_-_75972286	0.609	NM_004370 NM_080645	COL12A1	collagen, type XII, alpha 1
chr1_+_109810622	0.606	NM_001040709	SYPL2	synaptophysin-like 2
chr7_-_6490214	0.606	NM_001100603 NM_006854	KDELR2	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
chr11_+_113435640	0.606	NM_006006	ZBTB16	zinc finger and BTB domain containing 16
chr19_+_54996613	0.604
chr19_+_54149843	0.604	NM_004324 NM_138761 NM_138763 NM_138764	BAX	BCL2-associated X protein
chr17_-_37828643	0.599	NM_012232	PTRF	polymerase I and transcript release factor
chr11_+_69165119	0.596		CCND1	cyclin D1
chr16_-_4837266	0.585	NM_032569	GLYR1	glyoxylate reductase 1 homolog (Arabidopsis)
chr8_+_69026895	0.583		PREX2	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr1_-_143750988	0.583	NM_001198832	PDE4DIP	phosphodiesterase 4D interacting protein
chr13_+_112999538	0.582		LAMP1	lysosomal-associated membrane protein 1
chr1_+_109810743	0.582		SYPL2	synaptophysin-like 2
chr1_-_233879617	0.580	NM_001098722	GNG4	guanine nucleotide binding protein (G protein), gamma 4
chr17_+_46267603	0.577	NM_175575	WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
chr4_+_8645421	0.575		CPZ	carboxypeptidase Z
chr11_-_118740069	0.565	NM_171997	USP2	ubiquitin specific peptidase 2
chr11_+_69165018	0.564	NM_053056	CCND1	cyclin D1
chr1_+_29435534	0.557	NM_001195001 NM_005704 NM_133177 NM_133178	PTPRU	protein tyrosine phosphatase, receptor type, U
chr3_+_49211936	0.555	NM_001135197	CCDC36	coiled-coil domain containing 36
chr16_+_55580910	0.555	NM_032206	NLRC5	NLR family, CARD domain containing 5
chr15_+_41597097	0.550	NM_002373	MAP1A	microtubule-associated protein 1A
chr1_+_26368969	0.550	NM_015871	ZNF593	zinc finger protein 593
chr20_+_32610161	0.548	NM_032514	MAP1LC3A	microtubule-associated protein 1 light chain 3 alpha
chr10_-_128067052	0.543		ADAM12	ADAM metallopeptidase domain 12
chr7_+_5598964	0.543		FSCN1	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr15_-_61680003	0.537		LOC100130855	hypothetical LOC100130855
chr19_+_43502591	0.534		KCNK6	potassium channel, subfamily K, member 6
chr12_+_6768966	0.527		CD4	CD4 molecule
chr10_-_128067001	0.525		ADAM12	ADAM metallopeptidase domain 12
chr3_-_24511456	0.525		THRB	thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
chr11_+_69165065	0.520		CCND1	cyclin D1
chr16_-_65742323	0.518	NM_033309	B3GNT9	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9
chr3_+_50281582	0.517		SEMA3B	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr2_-_1727292	0.515	NM_012293	PXDN	peroxidasin homolog (Drosophila)
chr15_-_53667800	0.515		PYGO1	pygopus homolog 1 (Drosophila)
chr10_+_103815114	0.514	NM_024747	HPS6	Hermansky-Pudlak syndrome 6
chr3_-_69517913	0.514		FRMD4B	FERM domain containing 4B
chr7_-_37922902	0.512		SFRP4	secreted frizzled-related protein 4
chr9_+_130749812	0.509		NUP188	nucleoporin 188kDa
chr7_+_93862137	0.501		COL1A2 PLAG1	collagen, type I, alpha 2 pleiomorphic adenoma gene 1
chr11_+_66367458	0.499	NM_001032279 NM_005133	RCE1	RCE1 homolog, prenyl protein peptidase (S. cerevisiae)
chr1_-_206484258	0.498	NM_025179	PLXNA2	plexin A2
chr7_-_37923040	0.498	NM_003014	SFRP4	secreted frizzled-related protein 4
chr22_+_34107087	0.496		HMOX1	heme oxygenase (decycling) 1
chr19_+_43502380	0.495		KCNK6	potassium channel, subfamily K, member 6
chr12_+_6768866	0.488	NM_000616	CD4	CD4 molecule
chr1_-_191422346	0.488	NM_003783	B3GALT2	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr5_+_60663842	0.486	NM_020928	ZSWIM6	zinc finger, SWIM-type containing 6
chr6_-_127822227	0.484	NM_014702	KIAA0408	KIAA0408
chr3_+_44878380	0.483	NM_144638	TMEM42	transmembrane protein 42
chr3_+_50281309	0.480		SEMA3B	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr22_-_40315722	0.479	NM_002676	PMM1	phosphomannomutase 1
chr9_-_89779180	0.479		CDK20	cyclin-dependent kinase 20
chr4_-_141293572	0.478		MAML3	mastermind-like 3 (Drosophila)
chr6_+_30702586	0.475	NM_024909 NM_001031722 NM_001190724	ATAT1	alpha tubulin acetyltransferase 1
chr19_-_45888259	0.473	NM_004756	NUMBL	numb homolog (Drosophila)-like
chr8_+_37672427	0.473	NM_025069	ZNF703	zinc finger protein 703
chr7_+_100109359	0.469		GNB2	guanine nucleotide binding protein (G protein), beta polypeptide 2
chr6_-_5952096	0.468		NRN1	neuritin 1
chr20_+_29565898	0.466	NM_030789 NM_178580 NM_178581 NM_178582	HM13	histocompatibility (minor) 13
chr17_-_72045218	0.465	NM_134268	CYGB	cytoglobin
chr18_+_2645885	0.465	NM_015295	SMCHD1	structural maintenance of chromosomes flexible hinge domain containing 1
chr12_+_52634950	0.460	NM_173860	HOXC12	homeobox C12
chr20_+_29565922	0.460		HM13	histocompatibility (minor) 13
chr13_-_20533703	0.459	NM_014572	LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)
chr11_+_66140628	0.459	NM_001198845 NM_001198846 NM_001198836 NM_001198837 NM_006328	RBM14-RBM4 RBM14	RBM14-RBM4 readthrough RNA binding motif protein 14
chr10_-_128066935	0.458		ADAM12	ADAM metallopeptidase domain 12
chr5_+_159276317	0.453	NM_000679	ADRA1B	adrenergic, alpha-1B-, receptor
chr16_+_66855827	0.452	NM_001076785 NM_003983	SLC7A6	solute carrier family 7 (cationic amino acid transporter, y+ system), member 6
chr1_+_220857774	0.450	NM_198551	MIA3	melanoma inhibitory activity family, member 3
chr2_+_190916571	0.449		INPP1	inositol polyphosphate-1-phosphatase
chr5_+_121675672	0.448	NM_005460	SNCAIP	synuclein, alpha interacting protein
chr1_-_59020875	0.446		JUN	jun proto-oncogene
chr6_-_44333002	0.445	NM_178148	SLC35B2	solute carrier family 35, member B2
chr14_+_58174489	0.441	NM_001079520 NM_016651	DACT1	dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)
chr10_+_102749597	0.441		LZTS2	leucine zipper, putative tumor suppressor 2
chr16_+_415606	0.440		RAB11FIP3	RAB11 family interacting protein 3 (class II)
chr17_+_77529070	0.440		ASPSCR1	alveolar soft part sarcoma chromosome region, candidate 1
chr1_+_110494654	0.440	NM_001010898	SLC6A17	solute carrier family 6, member 17
chr16_-_4528739	0.438	NM_001199055 NM_001199056 NM_013399	C16orf5	chromosome 16 open reading frame 5
chr17_-_37221976	0.435	NM_006455	LEPREL4	leprecan-like 4
chr16_-_71639670	0.432	NM_006885	ZFHX3	zinc finger homeobox 3
chr21_-_37367259	0.430	NM_153682	PIGP	phosphatidylinositol glycan anchor biosynthesis, class P
chr16_+_76379901	0.429	NM_020927	VAT1L	vesicle amine transport protein 1 homolog (T. californica)-like
chr7_+_27190688	0.427
chr19_+_43502360	0.427		KCNK6	potassium channel, subfamily K, member 6
chr3_-_49370755	0.423	NM_000581 NM_201397	GPX1	glutathione peroxidase 1
chr9_+_136673464	0.423	NM_000093	COL5A1	collagen, type V, alpha 1
chr10_+_23768203	0.421	NM_001145373	OTUD1	OTU domain containing 1
chr1_+_13899272	0.421	NM_001135610	PRDM2	PR domain containing 2, with ZNF domain
chr1_-_181654027	0.421
chr16_-_31390926	0.420
chr3_-_49370682	0.417		GPX1	glutathione peroxidase 1
chr3_+_156280772	0.416	NM_007289	MME	membrane metallo-endopeptidase
chr13_-_27967215	0.414	NM_001159920 NM_001160030 NM_001160031 NM_002019	FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.85	6.71e-08	GO:0008104	protein localization
1.75	1.10e-07	GO:0033036	macromolecule localization
1.86	6.00e-06	GO:0015031	protein transport
1.84	7.41e-06	GO:0045184	establishment of protein localization
1.65	2.38e-05	GO:0051641	cellular localization
1.21	4.63e-05	GO:0050794	regulation of cellular process
1.19	4.33e-04	GO:0050789	regulation of biological process
1.54	5.29e-04	GO:0009653	anatomical structure morphogenesis
1.17	6.88e-04	GO:0065007	biological regulation
1.35	2.92e-03	GO:0048518	positive regulation of biological process
1.29	4.02e-03	GO:0031323	regulation of cellular metabolic process
2.16	4.07e-03	GO:0001501	skeletal system development
1.88	4.57e-03	GO:0034613	cellular protein localization
1.72	4.77e-03	GO:0016192	vesicle-mediated transport
1.36	5.31e-03	GO:0048522	positive regulation of cellular process
1.87	5.62e-03	GO:0070727	cellular macromolecule localization
2.80	6.16e-03	GO:0048193	Golgi vesicle transport
6.66	6.19e-03	GO:0048199	vesicle targeting, to, from or within Golgi
1.65	6.32e-03	GO:0006351	transcription, DNA-dependent
1.56	7.23e-03	GO:0051649	establishment of localization in cell
1.68	7.97e-03	GO:0046907	intracellular transport
1.24	9.55e-03	GO:0044260	cellular macromolecule metabolic process
1.10	1.02e-02	GO:0009987	cellular process
1.78	1.26e-02	GO:0009887	organ morphogenesis
1.28	1.45e-02	GO:0051179	localization
1.28	1.47e-02	GO:0080090	regulation of primary metabolic process
1.43	1.67e-02	GO:0009059	macromolecule biosynthetic process
1.42	2.15e-02	GO:0034645	cellular macromolecule biosynthetic process
1.57	2.41e-02	GO:0032774	RNA biosynthetic process
1.21	2.79e-02	GO:0043170	macromolecule metabolic process
1.25	3.47e-02	GO:0019222	regulation of metabolic process
4.94	4.22e-02	GO:0006903	vesicle targeting
1.30	4.35e-02	GO:0051171	regulation of nitrogen compound metabolic process

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.23	2.28e-12	GO:0043227	membrane-bounded organelle
1.23	2.76e-12	GO:0043231	intracellular membrane-bounded organelle
1.17	3.28e-12	GO:0044424	intracellular part
1.15	5.46e-11	GO:0005622	intracellular
1.19	5.67e-11	GO:0043229	intracellular organelle
1.19	5.80e-11	GO:0043226	organelle
2.17	6.53e-07	GO:0000139	Golgi membrane
1.26	8.47e-07	GO:0044422	organelle part
1.49	9.06e-07	GO:0031090	organelle membrane
1.26	2.28e-06	GO:0044446	intracellular organelle part
1.18	6.30e-06	GO:0005737	cytoplasm
1.72	6.97e-06	GO:0005794	Golgi apparatus
1.97	7.21e-06	GO:0044431	Golgi apparatus part
1.53	1.92e-05	GO:0012505	endomembrane system
1.22	4.21e-05	GO:0044444	cytoplasmic part
1.23	1.02e-04	GO:0005634	nucleus
1.54	1.94e-03	GO:0005783	endoplasmic reticulum
1.05	1.86e-02	GO:0044464	cell part
1.05	1.91e-02	GO:0005623	cell

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.68	5.55e-05	GO:0001071	nucleic acid binding transcription factor activity
1.68	5.55e-05	GO:0003700	sequence-specific DNA binding transcription factor activity
1.62	4.67e-04	GO:0030528	transcription regulator activity
1.17	5.10e-04	GO:0005515	protein binding
1.76	5.73e-04	GO:0043565	sequence-specific DNA binding