Motif ID: SPZ1.p2

Z-value: 1.481


Transcription factors associated with SPZ1.p2:

Gene SymbolEntrez IDGene Name
SPZ1 84654 spermatogenic leucine zipper 1



Activity profile for motif SPZ1.p2.

activity profile for motif SPZ1.p2


Sorted Z-values histogram for motif SPZ1.p2

Sorted Z-values for motif SPZ1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPZ1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_29819647 1.759 NM_181718
ASPHD1
aspartate beta-hydroxylase domain containing 1
chr16_+_29373365 1.660 NM_001014999
NM_001015000
NM_024044
NM_178044
SLX1A-SULT1A3
SLX1A

SLX1B

SLX1A-SULT1A3 read-through transcript
SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae)

SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)

chr14_+_23937766 1.560 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr10_+_123862430 1.506 TACC2
transforming, acidic coiled-coil containing protein 2
chrX_+_105856531 1.468 NM_194463
RNF128
ring finger protein 128
chr20_-_30535045 1.460 C20orf112
chromosome 20 open reading frame 112
chr12_+_64504835 1.393 HMGA2
high mobility group AT-hook 2
chr16_-_66535457 1.387 NM_000229
LCAT
lecithin-cholesterol acyltransferase
chr20_-_22513050 1.361 NM_021784
FOXA2
forkhead box A2
chr5_+_129268352 1.349 NM_175856
CHSY3
chondroitin sulfate synthase 3
chr22_-_19122047 1.294 SCARF2
scavenger receptor class F, member 2
chr14_-_24588916 1.259 NM_014178
STXBP6
syntaxin binding protein 6 (amisyn)
chr3_-_150858274 1.214 NM_001168280
NM_015472
WWTR1

WW domain containing transcription regulator 1

chr2_-_42873179 1.205 NM_012205
HAAO
3-hydroxyanthranilate 3,4-dioxygenase
chr4_-_118226119 1.157 NM_152402
TRAM1L1
translocation associated membrane protein 1-like 1
chr18_-_50777634 1.148 NM_025214
CCDC68
coiled-coil domain containing 68
chr9_+_115957537 1.148 COL27A1
collagen, type XXVII, alpha 1
chr12_-_47468985 1.132 NM_020983
ADCY6
adenylate cyclase 6
chr1_-_150070849 1.114 NM_005060
RORC
RAR-related orphan receptor C
chr17_+_72795567 1.112 NM_001113492
SEPT9
septin 9
chr1_+_199130571 1.090 NM_001142569
C1orf106
chromosome 1 open reading frame 106
chr2_+_70981223 1.086 NM_012476
VAX2
ventral anterior homeobox 2
chr7_+_94374862 1.076 NM_001166160
NM_017650
PPP1R9A

protein phosphatase 1, regulatory (inhibitor) subunit 9A

chr7_+_45894480 1.061 NM_000596
IGFBP1
insulin-like growth factor binding protein 1
chr2_-_220144254 1.033 OBSL1
obscurin-like 1
chr17_-_37144408 1.025 NM_001079870
NM_001079871
NM_177977
HAP1


huntingtin-associated protein 1


chr9_-_85342868 1.008 NM_174938
FRMD3
FERM domain containing 3
chr17_-_77824849 1.001 NM_001893
NM_139062
CSNK1D

casein kinase 1, delta

chr17_+_71582486 0.992 NM_003857
GALR2
galanin receptor 2
chr6_-_119712596 0.980 NM_005907
MAN1A1
mannosidase, alpha, class 1A, member 1
chr2_+_70981233 0.978 VAX2
ventral anterior homeobox 2
chr4_-_158111995 0.960 NM_016205
PDGFC
platelet derived growth factor C
chr9_-_106730157 0.935 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr2_+_54536780 0.930 NM_003128
SPTBN1
spectrin, beta, non-erythrocytic 1
chr6_-_128883125 0.926 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr3_+_125786195 0.925 NM_007064
KALRN
kalirin, RhoGEF kinase
chr11_-_2116775 0.922 NM_000612
IGF2
insulin-like growth factor 2 (somatomedin A)
chr6_-_116488458 0.916 NM_002031
FRK
fyn-related kinase
chr2_-_219633481 0.906 NM_002181
IHH
Indian hedgehog
chr1_-_159459999 0.904 NM_001643
APOA2
apolipoprotein A-II
chr3_+_152287365 0.898 NM_053002
MED12L
mediator complex subunit 12-like
chr9_+_135389698 0.893 NM_014694
ADAMTSL2
ADAMTS-like 2
chr11_-_116168316 0.892 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr2_+_119905812 0.887 NM_183240
TMEM37
transmembrane protein 37
chr1_-_20684858 0.878 CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr5_+_80292313 0.877 NM_006909
RASGRF2
Ras protein-specific guanine nucleotide-releasing factor 2
chr22_+_29122932 0.858 NM_012429
NM_033382
SEC14L2

SEC14-like 2 (S. cerevisiae)

chr1_+_15955719 0.850 FBLIM1
filamin binding LIM protein 1
chr16_-_51138306 0.848 NM_001080430
TOX3
TOX high mobility group box family member 3
chr11_-_70641267 0.838 SHANK2
SH3 and multiple ankyrin repeat domains 2
chr4_+_184257337 0.825 NM_024949
WWC2
WW and C2 domain containing 2
chr5_+_80292213 0.824 RASGRF2
Ras protein-specific guanine nucleotide-releasing factor 2
chrX_-_132947141 0.822 GPC3
glypican 3
chr14_-_22974707 0.813 NM_000257
MYH7
myosin, heavy chain 7, cardiac muscle, beta
chr12_+_106236281 0.808 NM_001018072
BTBD11
BTB (POZ) domain containing 11
chrX_-_132947290 0.801 NM_001164617
NM_001164618
NM_001164619
NM_004484
GPC3



glypican 3



chr20_-_17610704 0.799 RRBP1
ribosome binding protein 1 homolog 180kDa (dog)
chr1_-_24307514 0.798 MYOM3
myomesin family, member 3
chr1_+_151917674 0.797 NM_000906
NPR1
natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
chr3_-_187562470 0.792 NM_001080744
NM_001080745
NM_001346
DGKG


diacylglycerol kinase, gamma 90kDa


chr9_-_4289574 0.785 GLIS3
GLIS family zinc finger 3
chr16_-_66535923 0.784 SLC12A4
solute carrier family 12 (potassium/chloride transporters), member 4
chr20_-_22514092 0.782 NM_153675
FOXA2
forkhead box A2
chr12_+_50686990 0.782 NM_181711
GRASP
GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein
chr14_-_23686269 0.782 PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr10_-_101680645 0.778 DNMBP
dynamin binding protein
chr6_+_43036442 0.771 NM_018960
GNMT
glycine N-methyltransferase
chr12_-_48017223 0.768 NM_001008223
C1QL4
complement component 1, q subcomponent-like 4
chr2_+_242400702 0.763 NM_001167599
NM_001167602
NM_080741
NEU4


sialidase 4


chr15_-_68933481 0.761 NM_018357
NM_197958
LARP6

La ribonucleoprotein domain family, member 6

chr17_+_33761234 0.752 NM_014598
SOCS7
suppressor of cytokine signaling 7
chr20_+_3399615 0.752 NM_139321
NM_139322
ATRN

attractin

chr20_-_22512893 0.751 FOXA2
forkhead box A2
chr4_-_187884721 0.751


chr2_-_216944911 0.744 NM_020814
MARCH4
membrane-associated ring finger (C3HC4) 4
chr2_-_192767844 0.744 NM_016192
TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr7_+_113513600 0.734 FOXP2
forkhead box P2
chr4_-_158111504 0.734 PDGFC
platelet derived growth factor C
chr4_-_158111916 0.730 PDGFC
platelet derived growth factor C
chr19_+_39664706 0.724 NM_001080436
WTIP
Wilms tumor 1 interacting protein
chr14_-_22596522 0.717 NM_022478
NM_144985
CDH24

cadherin 24, type 2

chr10_-_105411339 0.716 SH3PXD2A
SH3 and PX domains 2A
chr4_-_22126437 0.711 NM_145290
GPR125
G protein-coupled receptor 125
chr17_+_35425139 0.708 NM_000759
NM_001178147
NM_172219
NM_172220
CSF3



colony stimulating factor 3 (granulocyte)



chr2_+_171280944 0.704 SP5
Sp5 transcription factor
chr12_+_56406296 0.698 LOC100130776
hypothetical LOC100130776
chr16_-_4778317 0.696 NM_001154458
NM_144605
SEPT12

septin 12

chr16_-_49742008 0.692 NM_001127892
SALL1
sal-like 1 (Drosophila)
chr2_-_36384 0.688 NM_001077710
FAM110C
family with sequence similarity 110, member C
chr3_+_106568430 0.687 ALCAM
activated leukocyte cell adhesion molecule
chr20_-_42457717 0.684


chr14_+_36196523 0.680 NM_006194
PAX9
paired box 9
chr7_+_29200850 0.680 CHN2
chimerin (chimaerin) 2
chr6_-_30151526 0.679 NM_170769
NM_025236
RNF39

ring finger protein 39

chr9_+_70926009 0.674 NM_001170414
TJP2
tight junction protein 2 (zona occludens 2)
chr12_-_6535481 0.673 NM_001039670
NM_001193457
NM_080730
IFFO1


intermediate filament family orphan 1


chr17_+_45405128 0.673 NM_001934
DLX4
distal-less homeobox 4
chr14_+_68796621 0.670 GALNTL1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 1
chr9_+_115958051 0.669 NM_032888
COL27A1
collagen, type XXVII, alpha 1
chr11_-_124272891 0.667 NM_019055
ROBO4
roundabout homolog 4, magic roundabout (Drosophila)
chr12_+_7174230 0.663 NM_014718
CLSTN3
calsyntenin 3
chr16_-_49742651 0.661 NM_002968
SALL1
sal-like 1 (Drosophila)
chr3_+_112273352 0.660 PVRL3
poliovirus receptor-related 3
chr16_+_56211410 0.654 NM_001145770
NM_005682
GPR56

G protein-coupled receptor 56

chr17_-_33179118 0.649 NM_000458
NM_001165923
HNF1B

HNF1 homeobox B

chr14_+_89597860 0.644 NM_022054
KCNK13
potassium channel, subfamily K, member 13
chr10_-_105604942 0.643 NM_014631
SH3PXD2A
SH3 and PX domains 2A
chr6_-_138231006 0.638


chr5_+_115326035 0.633 NM_173800
AQPEP
laeverin
chrX_-_152889815 0.624 NM_005334
HCFC1
host cell factor C1 (VP16-accessory protein)
chr4_-_1156362 0.622 SPON2
spondin 2, extracellular matrix protein
chr2_-_20075929 0.621 NM_002381
MATN3
matrilin 3
chr4_-_15694407 0.620 PROM1
prominin 1
chr2_-_20075889 0.620 MATN3
matrilin 3
chr18_-_22383066 0.619 NM_001136205
KCTD1
potassium channel tetramerisation domain containing 1
chr14_-_76677711 0.616 ZDHHC22
zinc finger, DHHC-type containing 22
chr17_+_41217435 0.616 CRHR1
corticotropin releasing hormone receptor 1
chr13_+_92677012 0.615 NM_005708
GPC6
glypican 6
chr1_-_151848039 0.609 S100A16
S100 calcium binding protein A16
chr7_+_78920846 0.609 LOC100505881
hypothetical LOC100505881
chr17_-_33178987 0.608 HNF1B
HNF1 homeobox B
chr12_-_78608154 0.607 PAWR
PRKC, apoptosis, WT1, regulator
chr20_-_9767406 0.607 NM_020341
NM_177990
PAK7

p21 protein (Cdc42/Rac)-activated kinase 7

chr6_+_96570565 0.606 NM_006581
FUT9
fucosyltransferase 9 (alpha (1,3) fucosyltransferase)
chr3_+_214668 0.605


chr19_+_52215982 0.604 NM_002517
NPAS1
neuronal PAS domain protein 1
chr15_-_73792234 0.601 NM_001897
CSPG4
chondroitin sulfate proteoglycan 4
chr14_-_22516271 0.601 NM_198086
JUB
jub, ajuba homolog (Xenopus laevis)
chr12_-_49878216 0.601 NM_002702
POU6F1
POU class 6 homeobox 1
chr2_-_160972606 0.601 RBMS1
RNA binding motif, single stranded interacting protein 1
chr5_+_79021401 0.599 NM_153610
CMYA5
cardiomyopathy associated 5
chr17_-_36469869 0.598 NM_001165252
LOC730755
keratin associated protein 2-4-like
chr2_-_165186603 0.597 NM_004490
GRB14
growth factor receptor-bound protein 14
chr11_+_2116486 0.595


chr7_-_44195405 0.593 NM_000162
GCK
glucokinase (hexokinase 4)
chr3_-_184316553 0.590 MCCC1
methylcrotonoyl-CoA carboxylase 1 (alpha)
chr6_-_24466258 0.587 NM_016356
DCDC2
doublecortin domain containing 2
chr22_-_22970850 0.587 NM_001099781
NM_001099782
NM_004121
GGT5


gamma-glutamyltransferase 5


chr14_-_59407103 0.577 NM_021136
RTN1
reticulon 1
chr6_+_32090516 0.577 NM_007293
NM_001002029
C4A
C4B
complement component 4A (Rodgers blood group)
complement component 4B (Chido blood group)
chr12_+_48026955 0.577 DNAJC22
DnaJ (Hsp40) homolog, subfamily C, member 22
chr13_-_33148899 0.574 STARD13
StAR-related lipid transfer (START) domain containing 13
chr16_-_14695930 0.573 NM_003561
PLA2G10
phospholipase A2, group X
chrX_-_132376660 0.573 NM_001448
GPC4
glypican 4
chr21_-_36774257 0.573 NM_001146079
NM_144492
CLDN14

claudin 14

chr2_+_223625105 0.572 NM_080671
KCNE4
potassium voltage-gated channel, Isk-related family, member 4
chr2_+_46378405 0.567 EPAS1
endothelial PAS domain protein 1
chr12_-_24606616 0.566 NM_152989
SOX5
SRY (sex determining region Y)-box 5
chr17_-_40858775 0.560 NM_199282
ARHGAP27
Rho GTPase activating protein 27
chr9_-_106730256 0.558 NM_005502
ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr16_+_65765256 0.556 NM_003946
NM_001185057
NOL3

nucleolar protein 3 (apoptosis repressor with CARD domain)

chr14_+_23527866 0.555 NM_198083
DHRS4
DHRS4L2
dehydrogenase/reductase (SDR family) member 4
dehydrogenase/reductase (SDR family) member 4 like 2
chr9_-_35105844 0.554 NM_025182
KIAA1539
KIAA1539
chr20_+_31334601 0.553 NM_033197
C20orf114
chromosome 20 open reading frame 114
chr6_-_31954730 0.552 SLC44A4
solute carrier family 44, member 4
chr17_+_4434024 0.550 NM_198501
SMTNL2
smoothelin-like 2
chr17_+_39603599 0.550 NM_080863
ASB16
ankyrin repeat and SOCS box containing 16
chr7_+_29200636 0.550 NM_004067
CHN2
chimerin (chimaerin) 2
chr11_+_101488380 0.544 NM_001195045
YAP1
Yes-associated protein 1
chr15_+_77511912 0.542 NM_015206
KIAA1024
KIAA1024
chr15_-_72804763 0.541 NM_000499
CYP1A1
cytochrome P450, family 1, subfamily A, polypeptide 1
chr17_-_35017650 0.540 NEUROD2
neurogenic differentiation 2
chr10_-_71753684 0.538 LRRC20
leucine rich repeat containing 20
chr7_-_103417198 0.537 NM_005045
NM_173054
RELN

reelin

chr8_+_30361485 0.534 NM_001008710
NM_001008711
NM_001008712
NM_006867
RBPMS



RNA binding protein with multiple splicing



chr5_+_5193442 0.534 NM_139056
ADAMTS16
ADAM metallopeptidase with thrombospondin type 1 motif, 16
chr17_-_74231266 0.533 CYTH1
cytohesin 1
chr15_+_58083798 0.531 FOXB1
forkhead box B1
chr16_+_56211150 0.530 GPR56
G protein-coupled receptor 56
chr22_+_39404940 0.528 NM_005297
MCHR1
melanin-concentrating hormone receptor 1
chr9_-_106705867 0.524 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr15_-_73792150 0.523 CSPG4
chondroitin sulfate proteoglycan 4
chr2_+_109729176 0.522 NM_023016
ANKRD57
ankyrin repeat domain 57
chr17_-_67628523 0.522 FLJ37644
hypothetical LOC400618
chr9_-_35553895 0.521 NM_001099951
NM_001164310
FAM166B

family with sequence similarity 166, member B

chr19_+_50373842 0.520 NM_212550
BLOC1S3
biogenesis of lysosomal organelles complex-1, subunit 3
chr2_-_165186232 0.519 GRB14
growth factor receptor-bound protein 14
chr6_+_43151922 0.518 NM_002821
NM_152880
NM_152881
NM_152882
PTK7



PTK7 protein tyrosine kinase 7



chr16_+_30667120 0.515 NM_000294
NM_001172432
PHKG2

phosphorylase kinase, gamma 2 (testis)

chr8_-_144726064 0.515 NM_001100878
C8orf73
chromosome 8 open reading frame 73
chr7_-_99411573 0.515 NM_001185
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr7_+_100792841 0.515 NM_133457
EMID2
EMI domain containing 2
chr2_-_127580975 0.514 NM_004305
NM_139343
NM_139344
NM_139345
NM_139346
NM_139347
NM_139348
NM_139349
NM_139350
NM_139351
BIN1









bridging integrator 1









chr15_-_71448194 0.512 HCN4
hyperpolarization activated cyclic nucleotide-gated potassium channel 4
chr14_-_22891263 0.508 NM_020372
SLC22A17
solute carrier family 22, member 17
chr11_-_35503720 0.508 NM_001001991
NM_015430
PAMR1

peptidase domain containing associated with muscle regeneration 1

chr1_-_21868380 0.507 NM_001145657
NM_002885
RAP1GAP

RAP1 GTPase activating protein

chr2_-_174538197 0.507 SP3
Sp3 transcription factor
chr14_-_26136799 0.507 NM_002515
NM_006489
NM_006491
NOVA1


neuro-oncological ventral antigen 1


chr8_-_145613034 0.507 SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr12_-_6680053 0.503 NM_153685
C12orf53
chromosome 12 open reading frame 53
chr11_-_124127295 0.501 NM_014312
VSIG2
V-set and immunoglobulin domain containing 2
chr10_-_118419459 0.500 NM_144661
C10orf82
chromosome 10 open reading frame 82
chr8_-_125809831 0.499 NM_014751
MTSS1
metastasis suppressor 1
chr19_+_49972965 0.499 NM_001130852
NM_012116
CBLC

Cas-Br-M (murine) ecotropic retroviral transforming sequence c

chr6_+_17390273 0.498 NM_001143941
RBM24
RNA binding motif protein 24
chr16_-_52877868 0.497 NM_024336
IRX3
iroquois homeobox 3
chr2_-_86889029 0.497 NM_001145873
CD8A
CD8a molecule
chr17_-_74432671 0.497 TIMP2
TIMP metallopeptidase inhibitor 2
chr2_-_192767494 0.495 TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.42 7.66e-13 GO:0007399 nervous system development
1.23 7.00e-12 GO:0023052 signaling
1.22 7.36e-11 GO:0032502 developmental process
1.39 7.44e-11 GO:0009653 anatomical structure morphogenesis
1.23 1.02e-10 GO:0007275 multicellular organismal development
1.26 2.89e-10 GO:0048731 system development
1.23 1.15e-09 GO:0007165 signal transduction
1.13 2.52e-09 GO:0050794 regulation of cellular process
1.29 9.82e-09 GO:0030154 cell differentiation
1.22 1.44e-08 GO:0048856 anatomical structure development
1.45 2.18e-08 GO:0022008 neurogenesis
1.28 2.29e-08 GO:0048869 cellular developmental process
1.46 4.25e-08 GO:0048699 generation of neurons
1.11 1.28e-07 GO:0065007 biological regulation
1.12 1.58e-07 GO:0050789 regulation of biological process
1.48 7.16e-07 GO:0030182 neuron differentiation
1.23 7.39e-07 GO:0048518 positive regulation of biological process
1.32 2.47e-06 GO:0009966 regulation of signal transduction
1.23 3.53e-06 GO:0048522 positive regulation of cellular process
1.43 4.34e-06 GO:0051173 positive regulation of nitrogen compound metabolic process
1.43 8.70e-06 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.16 9.00e-06 GO:0051716 cellular response to stimulus
1.32 1.13e-05 GO:0009893 positive regulation of metabolic process
1.33 1.52e-05 GO:0031325 positive regulation of cellular metabolic process
1.53 1.77e-05 GO:0000904 cell morphogenesis involved in differentiation
1.28 2.07e-05 GO:0023051 regulation of signaling
1.47 2.67e-05 GO:0009887 organ morphogenesis
1.06 3.11e-05 GO:0009987 cellular process
1.33 3.49e-05 GO:0010604 positive regulation of macromolecule metabolic process
1.45 3.86e-05 GO:0032989 cellular component morphogenesis
1.43 6.13e-05 GO:0010628 positive regulation of gene expression
1.35 6.21e-05 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.44 1.20e-04 GO:0045893 positive regulation of transcription, DNA-dependent
1.37 1.84e-04 GO:0031328 positive regulation of cellular biosynthetic process
1.52 1.86e-04 GO:0048812 neuron projection morphogenesis
1.52 1.91e-04 GO:0048667 cell morphogenesis involved in neuron differentiation
1.53 1.99e-04 GO:0007409 axonogenesis
1.35 2.00e-04 GO:0048468 cell development
1.45 2.08e-04 GO:0048666 neuron development
1.42 2.09e-04 GO:0051254 positive regulation of RNA metabolic process
1.90 2.21e-04 GO:0045165 cell fate commitment
1.16 2.38e-04 GO:0080090 regulation of primary metabolic process
1.16 2.72e-04 GO:0031323 regulation of cellular metabolic process
1.44 3.04e-04 GO:0000902 cell morphogenesis
1.34 4.61e-04 GO:0050793 regulation of developmental process
1.35 5.49e-04 GO:0009891 positive regulation of biosynthetic process
1.39 9.83e-04 GO:0009790 embryo development
1.45 1.49e-03 GO:0031175 neuron projection development
1.14 1.65e-03 GO:0019222 regulation of metabolic process
1.43 1.69e-03 GO:0051253 negative regulation of RNA metabolic process
1.36 1.69e-03 GO:0010557 positive regulation of macromolecule biosynthetic process
1.22 1.72e-03 GO:0048583 regulation of response to stimulus
1.20 1.74e-03 GO:0048523 negative regulation of cellular process
1.43 1.96e-03 GO:0045892 negative regulation of transcription, DNA-dependent
2.58 2.30e-03 GO:0045995 regulation of embryonic development
1.55 2.47e-03 GO:0007411 axon guidance
1.39 2.51e-03 GO:0030030 cell projection organization
1.19 2.97e-03 GO:0048519 negative regulation of biological process
1.35 3.04e-03 GO:2000026 regulation of multicellular organismal development
1.44 3.24e-03 GO:0048858 cell projection morphogenesis
1.37 3.25e-03 GO:0045595 regulation of cell differentiation
1.22 3.35e-03 GO:0007166 cell surface receptor linked signaling pathway
1.43 3.38e-03 GO:0032990 cell part morphogenesis
1.51 3.47e-03 GO:0048598 embryonic morphogenesis
1.61 5.24e-03 GO:0030036 actin cytoskeleton organization
1.11 5.89e-03 GO:0032501 multicellular organismal process
1.44 6.14e-03 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.17 7.17e-03 GO:0051171 regulation of nitrogen compound metabolic process
1.69 7.29e-03 GO:0048732 gland development
1.55 7.85e-03 GO:0030029 actin filament-based process
1.37 9.14e-03 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.44 1.06e-02 GO:0032583 regulation of gene-specific transcription
1.14 1.15e-02 GO:0060255 regulation of macromolecule metabolic process
1.43 1.21e-02 GO:0048646 anatomical structure formation involved in morphogenesis
1.94 1.45e-02 GO:0030323 respiratory tube development
1.95 1.50e-02 GO:0030278 regulation of ossification
1.42 1.51e-02 GO:0072358 cardiovascular system development
1.42 1.51e-02 GO:0072359 circulatory system development
1.16 1.65e-02 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.35 2.09e-02 GO:0010558 negative regulation of macromolecule biosynthetic process
1.44 2.32e-02 GO:0009968 negative regulation of signal transduction
1.36 2.54e-02 GO:0010629 negative regulation of gene expression
1.84 3.03e-02 GO:0060541 respiratory system development
1.33 3.11e-02 GO:0009890 negative regulation of biosynthetic process
1.35 3.43e-02 GO:0051172 negative regulation of nitrogen compound metabolic process
1.73 3.62e-02 GO:0034330 cell junction organization
1.35 3.69e-02 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.22 3.98e-02 GO:0065009 regulation of molecular function
1.33 4.02e-02 GO:0031327 negative regulation of cellular biosynthetic process
1.52 4.08e-02 GO:0035295 tube development
1.91 4.08e-02 GO:0030324 lung development
1.38 4.63e-02 GO:0007417 central nervous system development
1.50 4.91e-02 GO:0048729 tissue morphogenesis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.51 8.09e-08 GO:0030054 cell junction
1.77 2.27e-04 GO:0070161 anchoring junction
1.79 5.79e-04 GO:0005912 adherens junction
1.19 6.15e-04 GO:0044459 plasma membrane part
1.46 2.06e-03 GO:0031012 extracellular matrix
1.29 3.23e-03 GO:0042995 cell projection
1.21 3.95e-03 GO:0005856 cytoskeleton
1.42 6.18e-03 GO:0045202 synapse
1.41 1.13e-02 GO:0043005 neuron projection
1.17 1.44e-02 GO:0005829 cytosol
1.69 2.49e-02 GO:0005938 cell cortex
2.88 3.67e-02 GO:0030864 cortical actin cytoskeleton
2.42 4.09e-02 GO:0042641 actomyosin
1.44 4.12e-02 GO:0015629 actin cytoskeleton
1.42 4.46e-02 GO:0005578 proteinaceous extracellular matrix
1.56 4.91e-02 GO:0031252 cell leading edge

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.14 5.87e-12 GO:0005515 protein binding
1.06 3.53e-06 GO:0005488 binding
1.56 3.17e-04 GO:0016563 transcription activator activity
1.38 3.44e-04 GO:0043565 sequence-specific DNA binding
1.30 6.90e-04 GO:0001071 nucleic acid binding transcription factor activity
1.30 6.90e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
1.29 1.27e-03 GO:0030528 transcription regulator activity
1.38 4.04e-03 GO:0008092 cytoskeletal protein binding
1.32 4.58e-03 GO:0019899 enzyme binding
1.34 5.89e-03 GO:0046983 protein dimerization activity
1.47 2.41e-02 GO:0008134 transcription factor binding
1.40 3.03e-02 GO:0008047 enzyme activator activity
2.17 3.66e-02 GO:0003707 steroid hormone receptor activity
2.13 3.80e-02 GO:0004879 ligand-dependent nuclear receptor activity